CURRICULUM VITAE Stanley B. Prusiner, M.D. University Of
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Navy's More Colorjiul Admirals, the Guided Missile Frigate Clark Slides Down the Ways at Both Iron Works, Bath, Maine
Named after one of the US. Navy's more colorjiul admirals, the guided missile frigate Clark slides down the ways at Both Iron Works, Bath, Maine. The 445-foot warship honors Admiral Joseph J. (Jocko) Clark of World War II fame. The ship, designed for defense against submarines, aircrafi and surface ships, was christened by the admiral's widow, Olga, of New York City. (Photo by Ron Farr.) ALL WIND6 MAGAZINE OF THE U.S. NAVY - 56th YEAR OF PUBLICATION JULY 1979 NUMBER 750 Chief of Naval Operations: ADM Thomas B. Hayward Chiefof Information: RADM David M. Cooney OIC Navy Internal Relations Act: CAPT Robert K. Lewis Jr. Features 6 FEEDING THE FLEET I Tracing Navy chow from hardtack to today's 'Think Thm' menus Page 30 THEY EAT BETTER ABOARD DEWEY THAN THEY DO AT HOME It takes a lot of pride to put out three good meals a da\T WHO GOES WHERE AND WHY There's more to detailing than just writrng orders ONE FOOT IN THE UNIVERSE Dedication of the Albert Einstein memorial at the Natlonal Academy of Sciences NAVAL AVIATION MUSEUM - PHASE II Second part of Pensacola's building program is complete 39 HIS EYES ARE ON OLYMPIC GOLD A competitor has only one shot at the rowing event this summer in Moscow PATHS TO A COMMISSION Page 39 Eighth in a series on Rights and Benefits Departments 2 Currents 20 Bearings 48 Mail Buoy Covers Front: Working side by side, USS Dewey's MSSN Gary LeFande (left) and MS1 Paulino Arnancio help turn ordinary food items into savory dishes. -
Warburg Effect(S)—A Biographical Sketch of Otto Warburg and His Impacts on Tumor Metabolism Angela M
Otto Cancer & Metabolism (2016) 4:5 DOI 10.1186/s40170-016-0145-9 REVIEW Open Access Warburg effect(s)—a biographical sketch of Otto Warburg and his impacts on tumor metabolism Angela M. Otto Abstract Virtually everyone working in cancer research is familiar with the “Warburg effect”, i.e., anaerobic glycolysis in the presence of oxygen in tumor cells. However, few people nowadays are aware of what lead Otto Warburg to the discovery of this observation and how his other scientific contributions are seminal to our present knowledge of metabolic and energetic processes in cells. Since science is a human endeavor, and a scientist is imbedded in a network of social and academic contacts, it is worth taking a glimpse into the biography of Otto Warburg to illustrate some of these influences and the historical landmarks in his life. His creative and innovative thinking and his experimental virtuosity set the framework for his scientific achievements, which were pioneering not only for cancer research. Here, I shall allude to the prestigious family background in imperial Germany; his relationships to Einstein, Meyerhof, Krebs, and other Nobel and notable scientists; his innovative technical developments and their applications in the advancement of biomedical sciences, including the manometer, tissue slicing, and cell cultivation. The latter were experimental prerequisites for the first metabolic measurements with tumor cells in the 1920s. In the 1930s–1940s, he improved spectrophotometry for chemical analysis and developed the optical tests for measuring activities of glycolytic enzymes. Warburg’s reputation brought him invitations to the USA and contacts with the Rockefeller Foundation; he received the Nobel Prize in 1931. -
Fy2007 Fy2007
999557_Cov.qxd:Layout 1 10/25/07 12:56 PM Page 1 President’s Report President’s Report FY2007 FY2007 444 Green Street Gardner, MA 01440-1000 / USA (978) 632-6600 www.mwcc.edu 999557_Cov.qxd:Layout 1 10/25/07 12:56 PM Page 2 Start Near…Go Far 999557_Vellum:Layout 1 10/22/07 7:38 AM Page 1 As reflected in our slogan, we encourage Mount Wachusett Community College students to “Start near . Go far.” We help them to realize their potential, to follow their dreams . to literally go anywhere with the skills they gain here. We are a stepping stone for students to find who they really are, what their dreams really are, and to start fulfilling them. As an institution, we thrive on these same principles. Therefore, we pride ourselves on providing innovative programs, which often become best practices and models for the national and international community. MWCC now unfolds the results of the college’s first-ever capital campaign, which resulted in raising nearly $4 million. Because of the success of the capital campaign and the philanthropy of the community we serve, MWCC received the highest match from the state’s Endowment Incentive Matching program. We have now finished construction and opened the Garrison Center for Early Childhood Education, dedicated the college’s library to Leo and Theresa LaChance, and completed Phase I of library renovations. Furthermore, one of the individuals at the heart of this campaign, MWCC trustee and foundation board member Jim Garrison, received national recognition with a 2006 Benefactors Award from the Council for Resource Development for his dedication to the mission of MWCC. -
German Jews in the United States: a Guide to Archival Collections
GERMAN HISTORICAL INSTITUTE,WASHINGTON,DC REFERENCE GUIDE 24 GERMAN JEWS IN THE UNITED STATES: AGUIDE TO ARCHIVAL COLLECTIONS Contents INTRODUCTION &ACKNOWLEDGMENTS 1 ABOUT THE EDITOR 6 ARCHIVAL COLLECTIONS (arranged alphabetically by state and then city) ALABAMA Montgomery 1. Alabama Department of Archives and History ................................ 7 ARIZONA Phoenix 2. Arizona Jewish Historical Society ........................................................ 8 ARKANSAS Little Rock 3. Arkansas History Commission and State Archives .......................... 9 CALIFORNIA Berkeley 4. University of California, Berkeley: Bancroft Library, Archives .................................................................................................. 10 5. Judah L. Mages Museum: Western Jewish History Center ........... 14 Beverly Hills 6. Acad. of Motion Picture Arts and Sciences: Margaret Herrick Library, Special Coll. ............................................................................ 16 Davis 7. University of California at Davis: Shields Library, Special Collections and Archives ..................................................................... 16 Long Beach 8. California State Library, Long Beach: Special Collections ............. 17 Los Angeles 9. John F. Kennedy Memorial Library: Special Collections ...............18 10. UCLA Film and Television Archive .................................................. 18 11. USC: Doheny Memorial Library, Lion Feuchtwanger Archive ................................................................................................... -
Cambridge's 92 Nobel Prize Winners Part 2 - 1951 to 1974: from Crick and Watson to Dorothy Hodgkin
Cambridge's 92 Nobel Prize winners part 2 - 1951 to 1974: from Crick and Watson to Dorothy Hodgkin By Cambridge News | Posted: January 18, 2016 By Adam Care The News has been rounding up all of Cambridge's 92 Nobel Laureates, celebrating over 100 years of scientific and social innovation. ADVERTISING In this installment we move from 1951 to 1974, a period which saw a host of dramatic breakthroughs, in biology, atomic science, the discovery of pulsars and theories of global trade. It's also a period which saw The Eagle pub come to national prominence and the appearance of the first female name in Cambridge University's long Nobel history. The Gender Pay Gap Sale! Shop Online to get 13.9% off From 8 - 11 March, get 13.9% off 1,000s of items, it highlights the pay gap between men & women in the UK. Shop the Gender Pay Gap Sale – now. Promoted by Oxfam 1. 1951 Ernest Walton, Trinity College: Nobel Prize in Physics, for using accelerated particles to study atomic nuclei 2. 1951 John Cockcroft, St John's / Churchill Colleges: Nobel Prize in Physics, for using accelerated particles to study atomic nuclei Walton and Cockcroft shared the 1951 physics prize after they famously 'split the atom' in Cambridge 1932, ushering in the nuclear age with their particle accelerator, the Cockcroft-Walton generator. In later years Walton returned to his native Ireland, as a fellow of Trinity College Dublin, while in 1951 Cockcroft became the first master of Churchill College, where he died 16 years later. 3. 1952 Archer Martin, Peterhouse: Nobel Prize in Chemistry, for developing partition chromatography 4. -
Alumni Revue! This Issue Was Created Since It Was Decided to Publish a New Edition Every Other Year Beginning with SP 2017
AAlluummnnii RReevvuuee Ph.D. Program in Theatre The Graduate Center City University of New York Volume XIII (Updated) SP 2016 Welcome to the updated version of the thirteenth edition of our Alumni Revue! This issue was created since it was decided to publish a new edition every other year beginning with SP 2017. It once again expands our numbers and updates existing entries. Thanks to all of you who returned the forms that provided us with this information; please continue to urge your fellow alums to do the same so that the following editions will be even larger and more complete. For copies of the form, Alumni Information Questionnaire, please contact the editor of this revue, Lynette Gibson, Assistant Program Officer/Academic Program Coordinator, Ph.D. Program in Theatre, The Graduate Center, City University of New York, 365 Fifth Avenue, New York, NY 10016-4309. You may also email her at [email protected]. Thank you again for staying in touch with us. We’re always delighted to hear from you! Jean Graham-Jones Executive Officer Hello Everyone: his is the updated version of the thirteenth edition of Alumni Revue. As always, I would like to thank our alumni for taking the time to send me T their updated information. I am, as always, very grateful to the Administrative Assistants, who are responsible for ensuring the entries are correctly edited. The Cover Page was done once again by James Armstrong, maybe he should be named honorary “cover-in-chief”. The photograph shows the exterior of Shakespeare’s Globe in London, England and was taken in August 2012. -
9-Deoxy-A9,A12-13,14
Proc. Natl. Acad. Sci. USA Vol. 81, pp. 1317-1321, March 1984 Biochemistry 9-Deoxy-A9,A12-13,14-dihydroprostaglandin D2, a metabolite of prostaglandin D2 formed in human plasma (dehydration product of prostaglandin D2/serum albumin/cell growth inhibition) YOSHIHARU KIKAWA*, SHUH NARUMIYA*, MASANORI FUKUSHIMAt, HIROHISA WAKATSUKAt, AND OSAMU HAYAISHI§ *Department of Medical Chemistry, Kyoto University Faculty of Medicine, Sakyo-ku, Kyoto 606, Japan; tDepartment of Internal Medicine and Laboratory of Chemotherapy, Aichi Cancer Center, Chikusa-ku, Nagoya 464, Japan; tResearch Institute, Ono Pharmaceutical Co., Shimamoto, Mishima, Osaka 618, Japan; and §Osaka Medical College, Daigaku-cho, Takatsuki, Osaka 569, Japan Contributed by Osamu Hayaishi, November 8, 1983 ABSTRACT Incubation of prostaglandin D2 (PGD2) with from Sigma. Dimethylisopropylsilyl (Me2iPrSi) imidazole human plasma yielded a product that has been identified as 9- and methoxyamine hydrochloride were from Tokyo Kasei deoxy-9,10-didehydro-12,13-cdidehydro-13,14-dihydro-PGD2 (Tokyo). Sep-pak silica and Sep-pak C18 cartridges were (9-deoxy-_9,9'2-13,14-dihydro-PGD2). The identification was from Waters Associates. Precoated silica gel plates [G60- based on mass spectrometry, UV spectrometry, mobilities and (F254)] with concentration zones and silica gel 60 for column retention time on TLC and HPLC, and NMR. The conversion chromatography were from Merck. Sephadex LH-20 was a of PGD2 to this product was dependent on the incubation time product of Pharmacia. Solvents used in the extraction of and the amount of plasma added to a reaction mixture and was PGD2 metabolites for identification were distilled before use. abolished by prior boiling. -
Michael S. Brown, MD
DISTINGUISHED PHYSICIANS AND Michael S. Brown, M.D. Sir Richard Roberts, Ph.D. Winner, 1985 Nobel Prize in Physiology or Medicine Winner, 1993 Nobel Prize in Physiology or Medicine MEDICAL SCIENTISTS MENTORING Winner, 1988 Presidential National Medal of Science A globally prominent biochemist and molecular biologist, DELEGATES HAVE INCLUDED... Dr. Brown received the world’s most prestigious medical Dr. Roberts was awarded the Nobel Prize for his prize for his work describing the regulation of the groundbreaking contribution to discovering RNA splicing. cholesterol metabolism. His work laid the foundation for Dr. Roberts is dedicating his future research to GMO crops the class of drugs now called statins taken daily by more than 20 million and food sources, and demonstrating the effect they have on humanity. — GRANDg MASTERS — people worldwide. Ferid Murad, M.D., Ph.D. Mario Capecchi, Ph.D. Boris D. Lushniak, M.D., M.P.H Winner, 1998 Nobel Prize in Physiology or Medicine Academy Science Director The Surgeon General of the United States (acting, 2013-2014) Winner, 2007 Nobel Prize in Physiology or Medicine A world-renowned pioneer in biochemistry, Dr. Murad’s Winner, 2001 National Medal of Science Rear Admiral Lushniak, M.D., M.P.H., was the United award-winning research demonstrated that nitroglycerin Winner, 2001 Lasker Award States’ leading spokesperson on matters of public health, and related drugs help patients with heart conditions by Winner, 2003 Wolf Prize in Medicine overseeing the operations of the U.S. Public Health Service releasing nitric oxide into the body, thus relaxing smooth Mario Capecchi, Ph.D., a biophysicist, is a Distinguished Commissioned Corps, which consists of approximately muscles by elevating intracellular cyclic GMP, leading to vasodilation and Professor of Human Genetics at the University of Utah School of Medicine. -
Knockout Mice and Test-Tube Babies
© 2001 Nature Publishing Group http://medicine.nature.com FOREWORD Laskers for 2001: Knockout mice and test-tube babies Compared with mathematics and physics, biology and medi- Oliver Smithies independently devised an ingenious method cine are mainly empirical sciences. As there are no grand uni- of homologous recombination that allows the preplanned fied theories to guide experiments, conceptual advances in and precise mutation of any desired gene among the ~35,000 the biomedical sciences are crucially dependent on techno- contained within the genome of ES cells. Combination of logical innovations. Examples of such innovations that have the Capecchi–Smithies technique of gene targeting with the revolutionized biology include recombinant DNA, DNA se- Evans technique of ES cell biology led to the first knockout quencing, polymerase chain reaction and monoclonal anti- mice in 1989, an exceptional advance that completely bodies. Examples of new technologies that have changed the style of contemporary biomedical science by revolutionized the practice of medicine include the making it possible to study the function of almost any single heart–lung machine and open heart surgery, coronary an- gene. So far, more than 4,000 of the ~35,000 mouse genes giography and coronary bypass have been knocked out, and more surgery, computer-assisted tomog- than 500 mouse models of human raphy and positron-emission to- disease have been created. mography, and immunosuppression Knockout mice are used today by and organ transplantation. thousands of scientists, both in This year’s Lasker Awards cele- academia and in the pharmaceuti- brate the development of two tech- cal/biotechnology industry. nologies that are comparable in The rise of the mouse to such ex- inventiveness and impact to those alted status in biomedical research mentioned above. -
Liberal Arts Science $600 Million in Support of Undergraduate Science Education
Janelia Update |||| Roger Tsien |||| Ask a Scientist SUMMER 2004 www.hhmi.org/bulletin LIBERAL ARTS SCIENCE In science and teaching— and preparing future investigators—liberal arts colleges earn an A+. C O N T E N T S Summer 2004 || Volume 17 Number 2 FEATURES 22 10 10 A Wellspring of Scientists [COVER STORY] When it comes to producing science Ph.D.s, liberal arts colleges are at the head of the class. By Christopher Connell 22 Cells Aglow Combining aesthetics with shrewd science, Roger Tsien found a bet- ter way to look at cells—and helped to revolutionize several scientif-ic disciplines. By Diana Steele 28 Night Science Like to take risks and tackle intractable problems? As construction motors on at Janelia Farm, the call is out for venturesome scientists with big research ideas. By Mary Beth Gardiner DEPARTMENTS 02 I N S T I T U T E N E W S HHMI Announces New 34 Investigator Competition | Undergraduate Science: $50 Million in New Grants 03 PRESIDENT’S LETTER The Scientific Apprenticeship U P F R O N T 04 New Discoveries Propel Stem Cell Research 06 Sleeper’s Hold on Science 08 Ask a Scientist 27 I N T E R V I E W Toward Détente on Stem Cell Research 33 G R A N T S Extending hhmi’s Global Outreach | Institute Awards Two Grants for Science Education Programs 34 INSTITUTE NEWS Bye-Bye Bio 101 NEWS & NOTES 36 Saving the Children 37 Six Antigens at a Time 38 The Emergence of Resistance 40 39 Hidden Potential 39 Remembering Santiago 40 Models and Mentors 41 Tracking the Transgenic Fly 42 Conduct Beyond Reproach 43 The 1918 Flu: Case Solved 44 HHMI LAB BOOK 46 N O T A B E N E 49 INSIDE HHMI Dollars and Sense ON THE COVER: Nancy H. -
The Awards of Science: Beyond the Nobel Prize. Part 2. the Winners
The Awards of Science: Beyond the Nobel Prfze. Part 2. The Wfnners and Their Most-Cited Papers Number 50 December 10, 1984 In part one of this essay, 1we provided ty Lasker winners have won the Nobel— a list of 52 prizes described as “non- 39 of them before and 1 after winning the Nobel” awards. The reason for choosing Nobel, S according to Alice Fordyce, di- this term was somewhat tongue-in- rector, Albert Lasker Medical Research cheek. The Nobel Prize has attained Awards. such a position of prestige with both Another award that has often antici- scientists and the general public that pated the Nobel is the Gairdner Founda- other scientific awards seem to pale in tion Award. Sally-Anne Hrica, execu- comparison. This generalization is con- tive director, Gairdner Foundation, firmed by the public’s attitude toward notes that 27 Gairdner winners went on Nobel Prize winners. Like movie stars, to win the Nobel, while 2 received the Nobelists are often idolized and consult- Gairdner after the Nobel.G Recently, the ed by the press on topics for which they John Scott Award7 of Philadelphia was have little training. Nobelist Rosalyn given to Georges J.F. Kohler, Basel In- Yalow,z Veterans Administration Re- stitute of Immunology, and Cesar Mil- search Center, Bronx, New York, whose stein, Medical Research Council’s Labo- name is almost synonymous with radio- ratory, Cambridge. This selection was immunoassay, notes, “The Nobel Prize made almost a year before the Nobel gives you the opportunity to make a fool Prize announcements. of yourself in public. -
Lasker Awards Honor Trailblazers in Medical Research and Public Service
EMBARGOED FOR RELEASE UNTIL SEPTEMBER 14, 2009 FROM: The Albert and Mary Lasker Foundation New York, New York CONTACT: Rubenstein Communications, Inc. Charles Zehren 212-843-8590 [email protected] Janet Wootten 212-843-8032 [email protected] 2009 LASKER AWARDS HONOR TRAILBLAZERS IN MEDICAL RESEARCH AND PUBLIC SERVICE: John Gurdon and Shinya Yamanaka, for Breakthrough Research in Nuclear Reprogramming and Stem Cells Brian J. Druker, Nicholas B. Lydon and Charles L. Sawyers, for Lifesaving Discoveries in Treatment of Leukemia Michael R. Bloomberg, for Landmark Policy and Philanthropic Initiatives to Reduce Tobacco Use and Foster Public Health New York, Sept. 13, 2009 - The Albert and Mary Lasker Foundation, which for 64 years has championed the greatest breakthroughs in medical research, today announced the winners of the 2009 Lasker Awards for outstanding accomplishments in basic medical and clinical medical research, and public service. The three awards—recognized as the most prestigious medical research awards in the United States today— honor six visionaries whose insight and courage has led to dramatic advances that will prevent disease and prolong life. John Gurdon of Cambridge University and Shinya Yamanaka of Kyoto University will receive the 2009 Albert Lasker Basic Medical Research Award for breakthrough discoveries into the process that instructs specialized adult cells to form stem cells. Brian J. Druker of Oregon Health & Science University, Nicholas B. Lydon, formerly of Novartis, and Charles L. Sawyers of Memorial Sloan-Kettering Cancer Center will receive the 2009 Lasker~DeBakey Clinical Medical Research Award for groundbreaking work on the treatment of chronic myeloid leukemia. New York City Mayor Michael R.