A History of Autism

Total Page:16

File Type:pdf, Size:1020Kb

A History of Autism Change V -X ie F w e D r P w Click to buy NOW! w m o w c .d k. ocu-trac Change V -X ie F w e D r P w Click to buy NOW! w m o w c .d k. ocu-trac Praise for A History of Autism “No one has attempted to write the history of autism so comprehen- sively before. Adam Feinstein’s highly readable but remarkably thorough book contains a treasure-trove of conversations with the scientists, clin- icians, lobbyists, and parents who have shaped the development of autism in both research and policy. The timing of this book is opportune, as the pioneer generation becomes ‘emeritus.’ History-telling is never wholly objective, but Feinstein (the science-writer, parent, and international con- ference organizer) is better placed than almost anyone to document the extraordinary changes that have happened to the autism community world- wide since the 1940s onwards. This book is an important contribution to the history of medicine and a unique resource for future generations who will build on their predecessors.” Simon Baron-Cohen, Director, Autism Research Centre, Cambridge University “The material in A History of Autism is selected and worded with such enthusiasm, such personal engagement, that it is contagious. I couldn’t stop reading. This book is a monument; a milestone that we all owe to autism’s history.” Theo Peeters, Centre for Training in Autism, Belgium “From the many years before Kanner’s 1943 description when the condition was known by other names, through all that has happened to the present time, along with a glimpse of the future, Feinstein explores the evolutionary journey of autism in an enlightened, educational, and entertaining fashion. Nowhere will you find a more comprehensive, care- fully documented and eminently readable account of the history of autism than this book.” Darold A. Treffert, University of Wisconsin Medical School “Adam Feinstein provides an essential historical context for autism; one of the most contentious childhood diagnoses today. This is a grounding book for those ready to look beyond pet theories, ‘magic bullets’ and ‘treatment of the day.’ This book will navigate you beyond the idea of any ‘one autism’ and leave you with the clarity, hope and opportunity for new directions inherent in that realization.” Donna Williams, author and autism consultant Change V -X ie F w e D r P w Click to buy NOW! w m o w c .d k. ocu-trac “Of interest to researchers, clinicians and parents, this volume provides a detailed perspective on the history of autism and related disorders. Writing from the perspective of a parent, Adam Feinstein brings the people and concepts vividly to life in this insightful and comprehensive book.” Fred R. Volkmar, Child Study Center Yale University “The field of autism has been in need of a solid historical account of the many changes since Kanner first coined the term autism in 1943, and Feinstein’s book finally fills that gap. His novel approach of telling the story of autism through interviews with the pioneers, their associ- ates, and their family members is creative and fascinating. What wonderful stories these people tell, how well the author passes the stories on, and what a terrific way to relate the history of the field. “Feinstein’s deep understanding of the field leads to excellent ques- tions and penetrating discussions. This wonderful combination will be irresistible to anyone interested in how the field got to where it is now and where it might be going.” Gary B. Mesibov, University of North Carolina School of Medicine “This book outlines, from an unusual point of view, the history of the development of the concept of the spectrum of autistic conditions. The author’s account is brought to life in fascinating detail by his interviews with leading professionals (or their children who survive them), parents, and adults with autistic conditions. He reveals the controversies between professionals and the problems that still exist for families in different countries, as well as the progress that has been made. A book to be highly recommended to anyone with an interest in autism.” Lorna Wing, Honorary Consultant to the National Autistic Society, UK “Adam Feinstein’s book is a valuable contribution to the autism litera- ture. No other author has sought out the important scientific contributors to autism research; it is fascinating to read their current views, as well as a summary of their original contributions.” Susan E. Folstein, John P. Hussman Institute of Human Genomics “The story of autism only began remarkably recently. In this unique book you can listen to the voices of the opinion makers and learn what they thought about autism in times past and present. Pioneers who pushed the boundaries of knowledge since autism was first identified talk freely about their ideas and experiences.” Uta Frith, University College London Change V -X ie F w e D r P w Click to buy NOW! w m o w c .d k. ocu-trac A History of Autism Conversations with the Pioneers Adam Feinstein A John Wiley & Sons, Ltd., Publication Change V -X ie F w e D r P w Click to buy NOW! w m o w c .d k. ocu-trac This edition first published 2010 © 2010 Adam Feinstein Blackwell Publishing was acquired by John Wiley & Sons in February 2007. Blackwell’s publishing program has been merged with Wiley’s global Scientific, Technical, and Medical business to form Wiley-Blackwell. Registered Office John Wiley & Sons Ltd, The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, United Kingdom Editorial Offices 350 Main Street, Malden, MA 02148–5020, USA 9600 Garsington Road, Oxford, OX4 2DQ, UK The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK For details of our global editorial offices, for customer services, and for information about how to apply for permission to reuse the copyright material in this book please see our website at www.wiley.com/wiley-blackwell. The right of Adam Feinstein to be identified as the author of this work has been asserted in accordance with the UK Copyright, Designs and Patents Act 1988. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by the UK Copyright, Designs and Patents Act 1988, without the prior permission of the publisher. Wiley also publishes its books in a variety of electronic formats. Some content that appears in print may not be available in electronic books. Designations used by companies to distinguish their products are often claimed as trademarks. All brand names and product names used in this book are trade names, service marks, trademarks or registered trademarks of their respective owners. The publisher is not associated with any product or vendor mentioned in this book. This publication is designed to provide accurate and authoritative information in regard to the subject matter covered. It is sold on the understanding that the publisher is not engaged in rendering professional services. If professional advice or other expert assistance is required, the services of a competent professional should be sought. Library of Congress Cataloging-in-Publication Data Feinstein, Adam, 1957– A history of autism : conversations with the pioneers/Adam Feinstein. p.; cm. Includes bibliographical references and index. ISBN 978-1-4051-8654-4 (hb : alk. paper) – ISBN 978-1-4051-8653-7 (pb : alk. paper) 1. Autism–History. I. Title. [DNLM: 1. Autistic Disorder–history–Interview. 2. History, 20th Century–Interview. WM 11.1 F299h 2010] RC553.A88F45 2010 362.196′85882–dc22 2010006818 A catalogue record for this book is available from the British Library. Set in 10/12.5pt Plantin by Graphicraft Limited, Hong Kong Printed in Malaysia 1 2010 Unless otherwise indicated, all photographs are the author’s. Change V -X ie F w e D r P w Click to buy NOW! w m o w c .d k. ocu-trac For Johnny Change V -X ie F w e D r P w Click to buy NOW! w m o w c .d k. ocu-trac Change V -X ie F w e D r P w Click to buy NOW! w m o w c .d k. ocu-trac Contents Acknowledgments ix Foreword by Dame Stephanie Shirley xv Introduction 1 1 The Two Great Pioneers 9 2 The 1950s: The Seeds of Understanding 37 3 Blaming the Parents 54 4 The 1960s: The Parents Fight Back 76 5 The Two Teaching Pioneers 117 6 The 1970s: Major Steps Forward 139 7 Definition, Diagnosis, and Assessment: The History of the Tool 165 8 The 1980s and 1990s: Theories and Concepts 203 9 Autism in the Developing Nations 233 10 Where the Future Lies 265 Notes 298 Bibliography 339 Index 367 vii Change V -X ie F w e D r P w Click to buy NOW! w m o w c .d k. ocu-trac Change V -X ie F w e D r P w Click to buy NOW! w m o w c .d k. ocu-trac Acknowledgments First and foremost, I owe an immense debt of gratitude to Dame Stephanie Shirley. This book would not have been possible without her enormous generosity and support in financing my travels around the world to speak to the pioneers in the field of autism. I must express my huge appreciation to Professor Uta Frith, who was also on the steering committee which saw this book through to its com- pletion and, as one of the world’s foremost authorities on autism, gave me friendly advice combined with constructive criticism.
Recommended publications
  • 2010 Cancun, Mexico
    Welcome to the NINETIETH ANNUAL CONVENTION of the WESTERN PSYCHOLOGICAL ASSOCIATION APRIL 22-25, 2010 at the Fiesta Americana Condesa Cancun The 90th meeting of the Western Psychological Association has: , The WPA Film Festival , Outstanding Invited Speakers , Special Programs for Students and Teachers , A Forum for Your Research Visit WPA at: www.westernpsych.org HOSTED BY 1 Dear Conference Attendees: On behalf of the University of Southern California, it is my great pleasure to welcome you to the 90th Annual Western Psychological Association Convention. USC, the Col- lege of Letters, Arts and Sciences, and the Department of Psychology are pleased to serve as sponsors of the annual meeting. I would especially like to thank WP A Presi- dent Stanley Sue, Executive Officer Chris Cozby, and Program Chair Steven Lopez for this opportunity. Located in Los Angeles, USC is one of the world’s leading private research universities. In the fall of 2009, USC enrolled 17,000 undergraduates, and 18,000 graduate and professional students. As a global university, the convention’s theme of diversity and its setting in Mexico are consistent with our multiple initiatives to address diversity issues within the United States. The Princeton Review has selected USC as one of 81 “Colleges with a Conscience” based on its outstanding record of involvement in the surrounding community with its large proportion of Latino Americans, African Americans and Asian Americans. In addition, USC enrolls more international students than any other U.S. university. Several mem- bers of the College’s Psychology Department are devoted to cross-national research in Korea, China, Rwanda, Finland, Sweden and Mexico, as well as multicultural research within the U.S.
    [Show full text]
  • Bulletin Spring 2010
    THE UNIVE RSIT Y of EDINBU RGH SPRING 2010 bTHE UNIVuERSITY OlF ElDINeBURGH StTAFFiMAn GAZINE Life through a lens Our Vet School is captured on camera – page 8 One world, Cultivating the Hard to Mapping the one vision revolution swallow universe A new health academy The collective campus Can a government policy Physicist Dr Phil Clark on the aims to make the world effort to reduce our carbon improve the treatment of University’s role in the ATLAS a better place – page 7 footprint – page 10 depression? – page14 experiment – page 17 advertisement... “I want to help future generations of researchers continue our work.” THE UNIVERSITY of EDINBURGH CAMPAIGN Kath Melia is Professor of Nursing Studies role in developing nursing at Edinburgh, at the University of Edinburgh. This year, had remembered the University in her will, she took the significant step of making a gift a gesture which is helping the important in her will to help continue the work and work we are doing today. This has inspired research of the University. me to do the same.” Kath explains, “I was touched to find that a By making a gift in your will, you, too, former colleague, who had played a pivotal can help shape the future of Edinburgh. Legacies from former members of staff at the University of If you would like more information on leaving a legacy to the Edinburgh support teaching, facilities and research across the University of Edinburgh or if you have already done so, Schools and Colleges. We are very grateful for this commitment. please contact our Legacy team in confidence: This support is vital to help this work continue and legacies, big email: [email protected] and small, can make a difference to a research project or help [email protected] support a junior researcher present their work for the first time.
    [Show full text]
  • Annual Report Ist 2015-16
    ANNUAL REPORT2015-2016 Rohit, Class VI Raj Singh, Class V Gyanesh, Class VI Krishna, Class VI Neha, Class III We Aboutare a non–profit organizationVISHWAS working in the field of disability and development . The bedrock of our programmes is our fundamental belief in Equal Opportunity and Inclusion. It is our belief that everyone has a right to access basic healthcare and education irrespective of disability, gender, class or caste . Even within vulnerable groups, those with disability are most likely to get excluded. Vishwas is committed to addressing this discrimination. Vision A diverse and inclusive Society where every individual is ensured equal rights and opportunities in a dignified manner. Mission To promote the rights and interests of the disadvantaged and the disabled people in partnership with all stakeholders including the children, their families, community and the government by Building knowledge and capacities on inclusive practices and policies. Creating opportunities with meaningful participation. Overview of Vishwas Programmes VISHWAS VIDYALAYA ADULT TRAINING Providing an equitable and Supporting young adults with inclusive school system. skill development and life skills opportunities VISHWAS (Vision for Health, Welfare and RESEARCH AND Special Needs) COMMUNITY TRAINING BASED Enhancing operational REHABILITATION learning to bridge the gap Facilitating community between the intent and participation to provide a practice barrier free and inclusive environment 2 Note from the Chairperson Our annual report this year is particularly significant as it marks the tenth year of the journey of Vishwas. With this important milestone, while we reflect on our many achievements in the last decade, more importantly, we seek to plan for the next phase in our development with even greater vigour.
    [Show full text]
  • Translation and Usability of Autism Screening and Diagnostic Tools for Autism Spectrum Conditions in India
    Translation and usability of autism screening and diagnostic tools for Autism Spectrum Conditions in India. Rudra A1, Banerjee S2, Singhal N3, Barua M3, Mukerji S2, Chakrabarti B1,4 1 School of Psychology and Clinical Language Sciences, University of Reading, UK 2 Creating Connections, Kolkata, India 3 Action for Autism, National Centre for Autism, Delhi, India 4 Autism Research Centre, University of Cambridge, UK Banerjee S is now at University of Haifa, Haifa, Israel. [NOTE: This is the final author-version of the manuscript, the formatted and published version is available at the journal website at : http://onlinelibrary.wiley.com/doi/10.1002/aur.1404/abstract] Correspondence concerning this article should be addressed to: Dr. Bhismadev Chakrabarti School of Psychology and Clinical Language Sciences, University of Reading, Reading RG6 6AL, UK Email: [email protected] Phone: +44 118 378 5551 Fax: +44 118 378 6715 Grant sponsor: Autism Speaks Lay Abstract: Among all the major developing countries, India is conspicuous by the absence of an estimate of autism prevalence. One key reason for this absence is the the lack of availability of standardized screening and diagnostic tools (SDT) for autism in regional languages in India. To address this gap, we translated four widely-used SDT (Social Communication Disorder Checklist, Autism Spectrum Quotient, Social Communication Questionnaire, Autism Diagnostic Observation Schedule) into Hindi and Bengali, two of the main regional languages (~360 million speakers) and tested their usability. We tested these translated instruments on 170 children with and without autism, and found that scores of children with autism were significantly and reliably different from those of control children.
    [Show full text]
  • May 9-12 Rotterdam Netherlands
    2018 ANNUAL MEETING MAY 9-12 ROTTERDAM NETHERLANDS PROGRAM BOOK www.autism-insar.org INSAR 2018 Sponsors We thank the following organizations for their generous support of the INSAR Annual Meeting. Platinum Sponsor Level Gold Sponsor Level Silver Sponsor Level Autism Science Foundation Hilibrand Foundation Nancy Lurie Marks Family Foundation TABLE OF CONTENTS Sponsorship .................................Inside Front Cover TABLE OF CONTENTS Special Interest Groups Schedule .......................... 6 Speaker Ready Room ............................................ 6 De Doelen Floor Plans ........................................ 7-9 Meeting Information Schedule-At-A-Glance .................................... 10-12 In-Conjunction Events .................................... 13-14 Keynote Speakers .............................................. 15 Awardees ..................................................... 16-19 INSAR MISSION Acknowledgments .......................................... 20-21 STATEMENT To promote the highest quality INSAR Summer Institute .................................... 22 research in order to improve the Abstract Author Index ...................................... 134 lives of people affected by autism. General Information .......................................... 208 Exhibitors ....................................................... 210 Strategic Initiatives Setting the Bar: Increase the quality, AM diversity and relevance of research promoted through annual meetings, journal, Keynote Address ...............................................
    [Show full text]
  • Instructor Will Post This Information in Week 1 Welcome Announcement
    Syllabus Page 1 of 10 AB583SA: Special Topics III- Study of China 3 Credit Hours Spring 2, 2019 Travel Dates: 4/22/19-5/1/19 Course Introduction Instructor: Office and Hours: Instructor will post this information in Week 1 welcome Phone: announcement. E-mail: Official Course Description: This interdisciplinary course will examine how behavioral analysis and related fields in psychology design applied solutions to complex social problems within the cultural contexts of China and our own communities. We will analyze behavioral analysis and other disciplinary interventions for issues such as psychiatric care, adoption, and the education of learners with special needs. Students will also consider ethics related to creating meaningful changes through their practice. While in China, students will meet learners with special needs in schools and talk with educational experts, learn about educational and organizational histories within the culture, explore interventions for individuals with mental health diagnoses, discuss topics with organizational and educational leaders and university students in China, and experience a variety of cultural events. Institutional Learning Goals, Competencies and Outcomes Institutional Learning Goals Please refer to the 2014-2015 Statement of Values for a description of how our Institutional Learning Goals are derived. Diversity Graduates will respect the value and dignity of individuals and groups across all cultural contexts, and advocate for inclusion and equity. They will demonstrate intercultural competence in domestic and international contexts with people who have ideas, beliefs, worldviews, experiences, and behaviors that are different from their own. By the end of this course, students will be able to… 1. Demonstrate knowledge of the world-view of the local culture within the context of psychology.
    [Show full text]
  • Becoming Autistic: How Do Late Diagnosed Autistic People
    Becoming Autistic: How do Late Diagnosed Autistic People Assigned Female at Birth Understand, Discuss and Create their Gender Identity through the Discourses of Autism? Emily Violet Maddox Submitted in accordance with the requirements for the degree of Master of Philosophy The University of Leeds School of Sociology and Social Policy September 2019 1 Table of Contents ACKNOWLEDGEMENTS ................................................................................................................................... 5 ABSTRACT ....................................................................................................................................................... 6 ABBREVIATIONS ............................................................................................................................................. 7 CHAPTER ONE ................................................................................................................................................. 8 INTRODUCTION .............................................................................................................................................. 8 1.1 RESEARCH OBJECTIVES ........................................................................................................................................ 8 1.2 TERMINOLOGY ................................................................................................................................................ 14 1.3 OUTLINE OF CHAPTERS ....................................................................................................................................
    [Show full text]
  • The Persistence of Fad Interventions in the Face of Negative Scientific Evidence: Facilitated Communication for Autism As a Case Example
    Evidence-Based Communication Assessment and Intervention ISSN: 1748-9539 (Print) 1748-9547 (Online) Journal homepage: http://www.tandfonline.com/loi/tebc20 The persistence of fad interventions in the face of negative scientific evidence: Facilitated communication for autism as a case example Scott O. Lilienfeld, Julia Marshall, James T. Todd & Howard C. Shane To cite this article: Scott O. Lilienfeld, Julia Marshall, James T. Todd & Howard C. Shane (2014) The persistence of fad interventions in the face of negative scientific evidence: Facilitated communication for autism as a case example, Evidence-Based Communication Assessment and Intervention, 8:2, 62-101, DOI: 10.1080/17489539.2014.976332 To link to this article: http://dx.doi.org/10.1080/17489539.2014.976332 Published online: 02 Feb 2015. Submit your article to this journal Article views: 5252 View related articles View Crossmark data Citing articles: 1 View citing articles Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=tebc20 Download by: [University of Lethbridge] Date: 05 October 2015, At: 05:52 Evidence-Based Communication Assessment and Intervention, 2014 Vol. 8, No. 2, 62–101, http://dx.doi.org/10.1080/17489539.2014.976332 EBP Advancement Corner The persistence of fad interventions in the face of negative scientific evidence: Facilitated communication for autism as a case example Scott O. Lilienfeld1, Julia Marshall1, James T. Todd2 & Howard C. Shane3 1Department of Psychology, Emory University, Atlanta, GA, USA, 2Department of Psychology, Eastern Michigan University, Ypsilanti, MI, USA, 3Boston Children’s Hospital, Boston, MA, USA ................................................................................................................................................. Abstract Communication disorder and mental health professionals may assume that once novel clinical techniques have been refuted by research, they will be promptly abandoned.
    [Show full text]
  • AUTISTIC SPECTRUM DISORDERS a Guide to Services for Children
    the Foundation for People with Learning Disabilities AUTISTIC SPECTRUM DISORDERS A Guide to Services for Children with Autistic Spectrum Disorders for Commissioners and Providers Rita Jordan, Glenys Jones & Hugh Morgan The Mental Health Foundation is the UK’s leading charity working for the needs of people with mental health problems and those with learning disabilities. We aim to improve people’s lives, reduce stigma surrounding the issues and to promote understanding. We fund research and help develop community services. We provide information for the general public and health and social care professionals. We aim to maximise expertise and resources by creating partnerships between ourselves and others including Government, health and social services. Since October 1998, The Foundation’s work with people with learning disabilities has been carried out under the name, the Foundation for People with Learning Disabilities. It remains part of the Mental Health Foundation. The Foundation for People with Learning Disabilities would like to thank The Shirley Foundation for funding this publication. Contents Contents Introduction ___________________________________________________ 2 Section 1: Definition, Identification and Diagnosis ________________ 3 What is an Autistic Spectrum Disorder? _________________________ 3 The Triad of Impairments in Autistic Spectrum Disorders _________ 3 Levels of Explanation __________________________________________ 5 Individual Differences __________________________________________ 6 Associated Conditions __________________________________________
    [Show full text]
  • Rhythm and Timing in Autism: Learning to Dance
    REVIEW ARTICLE published: 19 April 2013 INTEGRATIVE NEUROSCIENCE doi: 10.3389/fnint.2013.00027 Rhythm and timing in autism: learning to dance Pat Amos* Training and Private Consultation, Ardmore, PA, USA Edited by: In recent years, a significant body of research has focused on challenges to neural Anne M. Donnellan, University of connectivity as a key to understanding autism. In contrast to attempts to identify a Wisconsin-Madison, University of single static, primarily brain-based deficit, children and adults diagnosed with autism are San Diego, USA increasingly perceived as out of sync with their internal and external environments in Reviewed by: Elizabeth B. Torres, Rutgers dynamic ways that must also involve operations of the peripheral nervous systems. The University, USA noisiness that seems to occur in both directions of neural flow may help explain challenges Trevor McDonald, Education to movement and sensing, and ultimately to entrainment with circadian rhythms and social Associates Inc., USA interactions across the autism spectrum, profound differences in the rhythm and timing of *Correspondence: movement have been tracked to infancy. Difficulties with self-synchrony inhibit praxis, and Pat Amos, 635 Ardmore Avenue, Ardmore, PA 19003-1831, USA. can disrupt the “dance of relationship” through which caregiver and child build meaning. e-mail: [email protected] Different sensory aspects of a situation may fail to match up; ultimately, intentions and actions themselves may be uncoupled. This uncoupling may help explain the expressions of alienation from the actions of one’s body which recur in the autobiographical autism literature. Multi-modal/cross-modal coordination of different types of sensory information into coherent events may be difficult to achieve because amodal properties (e.g., rhythm and tempo) that help unite perceptions are unreliable.
    [Show full text]
  • The Repetitive Behaviour Questionnaires
    The Repetitive Behaviour Questionnaires Background information The information below is provided by the Wales Autism Research Centre, Cardiff University and Newcastle University. Each Repetitive Behaviour Questionnaire is listed and the reference and online link for the published validation studies are provided. Please see the published studies for information about psychometric properties. Repetitive Behaviour Questionnaire-2 (RBQ-2): A 20-item parent questionnaire designed to measure children’s restricted, repetitive and sensory behaviours. This was created by Prof Sue Leekam and Dr Michelle Turner at Durham University. Originally it was designed as a brief questionnaire for use in longitudinal studies. Subsequently it has been widely used for a range of different general and clinical populations. The items come from the from the original RBQ (Turner, 1995; Honey et al., 2012; see below) and the Diagnostic Interview for Social and Communication Disorders (DISCO; Wing, 2002). The RBQ-2 was first validated in a research collaboration between Durham and Newcastle University in 2007: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1469-7610.2007.01778.x Leekam, S, Tandos, J., McConachie, H., Meins, E., Parkinson, K., Wright, C.,Turner, M., Arnott, B., Vittorini, L., & Le Couteur, A. (2007). Repetitive behaviours in typically developing 2-year-olds. Journal of Child Psychology and Psychiatry, 48, 11, 1131-1138. doi: 10.1111/j.1469-7610.2007.01778.x Adult Repetitive Behaviour Questionnaire-2 (RBQ-2A): A 20-item self-report questionnaire designed to measure adults’ restricted, repetitive and sensory behaviours. This was created by Dr Sarah Barrett for her PhD at Cardiff University with Prof Sue Leekam and Dr Catherine Jones, Cardiff University.
    [Show full text]
  • Neuroanatomy-Of-Autism.Pdf
    Review Neuroanatomy of autism David G. Amaral1, Cynthia Mills Schumann2 and Christine Wu Nordahl1 1 The M.I.N.D. Institute, Department of Psychiatry and Behavioral Sciences, University of California, Davis, 2825 50th Street, Sacramento, CA 95817, USA 2 Department of Neurosciences, University of California, San Diego, 8110 La Jolla Shores Drive, Suite 201, La Jolla, CA 92037, USA Autism spectrum disorder is a heterogeneous, behavio- an autism that is generally indistinguishable from early- rally defined, neurodevelopmental disorder that occurs onset autism [7]. The possibility that there is early-onset in 1 in 150 children. Individuals with autism have deficits versus regressive phenotypes of autism might have import- in social interaction and verbal and nonverbal communi- ant implications for the types and time courses of neuro- cation and have restricted or stereotyped patterns of pathology that one might expect to encounter. behavior. They might also have co-morbid disorders including intellectual impairment, seizures and anxiety. Where might one expect to see neuropathology? Postmortem and structural magnetic resonance imaging In Figure 1, we summarize the major brain regions that studies have highlighted the frontal lobes, amygdala and form the putative neural systems involved in the functions cerebellum as pathological in autism. However, there is that are most impacted by the core features of autism. no clear and consistent pathology that has emerged for Several brain regions have been implicated in social beha- autism. Moreover, recent studies emphasize that the vior through experimental animal studies, lesion studies in time course of brain development rather than the final human patients or functional imaging studies [8].
    [Show full text]