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Applying Polygenic Risk Scoring for Psychiatric Disorders to a Large
http://www.diva-portal.org This is the published version of a paper published in . Citation for the original published paper (version of record): de Jong, S., Abdalla Diniz, M J., Saloma, A., Gadelha, A., Santoro, M L. et al. (2018) Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder Communications Biology, 1: 163 https://doi.org/10.1038/s42003-018-0155-y Access to the published version may require subscription. N.B. When citing this work, cite the original published paper. Permanent link to this version: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-157800 ARTICLE DOI: 10.1038/s42003-018-0155-y OPEN Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder Simone de Jong1,2, Mateus Jose Abdalla Diniz3,4, Andiara Saloma3,4, Ary Gadelha3, Marcos L. Santoro5, 1234567890():,; Vanessa K. Ota3,5, Cristiano Noto3, Major Depressive Disorder and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium#, Charles Curtis1,2, Stephen J. Newhouse2,6,7, Hamel Patel2,6, Lynsey S. Hall8, Paul F. O`Reilly1, Sintia I. Belangero3,5, Rodrigo A. Bressan3 & Gerome Breen 1,2 Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. -
Orme) Wilberforce (Albert) Raymond Blackburn (Alexander Bell
Copyrights sought (Albert) Basil (Orme) Wilberforce (Albert) Raymond Blackburn (Alexander Bell) Filson Young (Alexander) Forbes Hendry (Alexander) Frederick Whyte (Alfred Hubert) Roy Fedden (Alfred) Alistair Cooke (Alfred) Guy Garrod (Alfred) James Hawkey (Archibald) Berkeley Milne (Archibald) David Stirling (Archibald) Havergal Downes-Shaw (Arthur) Berriedale Keith (Arthur) Beverley Baxter (Arthur) Cecil Tyrrell Beck (Arthur) Clive Morrison-Bell (Arthur) Hugh (Elsdale) Molson (Arthur) Mervyn Stockwood (Arthur) Paul Boissier, Harrow Heraldry Committee & Harrow School (Arthur) Trevor Dawson (Arwyn) Lynn Ungoed-Thomas (Basil Arthur) John Peto (Basil) Kingsley Martin (Basil) Kingsley Martin (Basil) Kingsley Martin & New Statesman (Borlasse Elward) Wyndham Childs (Cecil Frederick) Nevil Macready (Cecil George) Graham Hayman (Charles Edward) Howard Vincent (Charles Henry) Collins Baker (Charles) Alexander Harris (Charles) Cyril Clarke (Charles) Edgar Wood (Charles) Edward Troup (Charles) Frederick (Howard) Gough (Charles) Michael Duff (Charles) Philip Fothergill (Charles) Philip Fothergill, Liberal National Organisation, N-E Warwickshire Liberal Association & Rt Hon Charles Albert McCurdy (Charles) Vernon (Oldfield) Bartlett (Charles) Vernon (Oldfield) Bartlett & World Review of Reviews (Claude) Nigel (Byam) Davies (Claude) Nigel (Byam) Davies (Colin) Mark Patrick (Crwfurd) Wilfrid Griffin Eady (Cyril) Berkeley Ormerod (Cyril) Desmond Keeling (Cyril) George Toogood (Cyril) Kenneth Bird (David) Euan Wallace (Davies) Evan Bedford (Denis Duncan) -
J?, ///? Minor Professor
THE PAPAL AGGRESSION! CREATION OF THE ROMAN CATHOLIC HIERARCHY IN ENGLAND, 1850 APPROVED! Major professor ^ J?, ///? Minor Professor ItfCp&ctor of the Departflfejalf of History Dean"of the Graduate School THE PAPAL AGGRESSION 8 CREATION OP THE SOMAN CATHOLIC HIERARCHY IN ENGLAND, 1850 THESIS Presented to the Graduate Council of the North Texas State University in Partial Fulfillment of the Requirements For she Degree of MASTER OF ARTS By Denis George Paz, B. A, Denton, Texas January, 1969 PREFACE Pope Plus IX, on September 29» 1850, published the letters apostolic Universalis Sccleslae. creating a terri- torial hierarchy for English Roman Catholics. For the first time since 1559» bishops obedient to Rome ruled over dioceses styled after English place names rather than over districts named for points of the compass# and bore titles derived from their sees rather than from extinct Levantine cities« The decree meant, moreover, that6 in the Vati- k can s opinionc England had ceased to be a missionary area and was ready to take its place as a full member of the Roman Catholic communion. When news of the hierarchy reached London in the mid- dle of October, Englishmen protested against it with unexpected zeal. Irate protestants held public meetings to condemn the new prelates» newspapers cried for penal legislation* and the prime minister, hoping to strengthen his position, issued a public letter in which he charac- terized the letters apostolic as an "insolent and insidious"1 attack on the queen's prerogative to appoint bishops„ In 1851» Parliament, despite the determined op- position of a few Catholic and Peellte members, enacted the Ecclesiastical Titles Act, which imposed a ilOO fine on any bishop who used an unauthorized territorial title, ill and permitted oommon informers to sue a prelate alleged to have violated the act. -
Honour's Role in the International States' System
Denver Journal of International Law & Policy Volume 31 Number 2 Winter Article 2 April 2020 Honour's Role in the International States' System Allen Z. Hertz Follow this and additional works at: https://digitalcommons.du.edu/djilp Recommended Citation Allen Z. Hertz, Honour's Role in the International States' System, 31 Denv. J. Int'l L. & Pol'y 113 (2002). This Article is brought to you for free and open access by Digital Commons @ DU. It has been accepted for inclusion in Denver Journal of International Law & Policy by an authorized editor of Digital Commons @ DU. For more information, please contact [email protected],[email protected]. HONOUR'S ROLE IN THE INTERNATIONAL STATES' SYSTEM* ALLEN Z. HERTZ* INTRODUCTION AND SUMMARY Studying the First World War's origins, James Joll (1918-1994), Professor of International History at the University of London, offered this insight: "In the late 20th century we perhaps find it easier to conceive of foreign policy as being motivated by domestic preoccupations and by economic interests than by... considerations of prestige and glory. It does not necessarily follow that the men of 1914 thought in the same way as we do."' To recapture that age which ended during the First World War, this essay analyzes the meaning of "honour" as a staple of European political philosophy. The significance of the "word of honour" is then located in the context of European courtly society, where a king's honour is explored in relation to that of his country and in the "international of kings" that was the European States' system until 1917-18. -
Japan Looking at the World Looking at Japan : European Expansion Into
Japan Looking at the World Looking at Japan European Expansion into East Asia, the Formation of the Japanese Concept and Perception of Colonial Rule as well as European Responses c. 19001 Harald Kleinschmidt, Tokyo An Interactionist Approach to the History of International Relations On 8 February 1868, the newly installed Meiji Government of Japan issued its proclamation nr 5. In this proclamation, it declared that it would honor the treaties that had been concluded between Japan and states in Europe and North America since 1854, but that it would also seek their revision in ac- cordance with ‘universal public law’ 宇内の公法 (udai no kōhō). On behalf of the government, Higashikuze Michitomi 東久世通禧, then in office as Director General Agency for Foreign Affairs 外国事務総督 (Gaikoku Jimu Sōtoku), communicated the contents of the proclamation to foreign diplo- matic envoys then accredited in Japan.2 The proclamation thus articulated the perception that there was a hierarchy of two legal frameworks that could be addressed for different, if not mutually exclusive purposes. Within this 1 Paper read to the Historical Institute of the University of Greifswald, 24 April 2017. 2 GENERAL AGENCY FOR FOREIGN AFFAIRS 外国事務総督 (Gaikoku Jimu Sōtoku): “Gaikō ni kan suru Fukokusho 外交に関スル布告書” (Government Proclamation Relating to Diplomacy [dated 8 February 1868 = 15th day of the first month of year Keio 4, concerning the treaties between Japan and other states, written by ŌKUBO Toshimichi 大 久保利道 and MUTSU Munemitsu 陸奥宗光]), Dai Nihon gaikō monjo 大日本外交文書 (Diplomatic Records of Japan), nr 97, vol. 1, Nihon Kokusai Kyōkai 日本国際協会 1938: 227–28. HIGASHIKUZE Michitomi: Nikki 日記 (Diary), vol. -
This Copy of the Thesis Has Been Supplied on Condition That Anyone
University of Plymouth PEARL https://pearl.plymouth.ac.uk 04 University of Plymouth Research Theses 01 Research Theses Main Collection 2017 The Times and the Manchester Guardian's editorial perspectives on Irish Home Rule and the adoption of referendum debates during the British constitutional crisis: December 1910-August 1911 Moore, David Frederick Ernest http://hdl.handle.net/10026.1/10268 University of Plymouth All content in PEARL is protected by copyright law. Author manuscripts are made available in accordance with publisher policies. Please cite only the published version using the details provided on the item record or document. In the absence of an open licence (e.g. Creative Commons), permissions for further reuse of content should be sought from the publisher or author. This copy of the thesis has been supplied on condition that anyone who consults it is understood to recognize that its copyright rests with its author and that no quotation from the thesis and no information derived from it may be published without the author’s prior consent. The Times and the Manchester Guardian’s editorial perspectives on Irish Home Rule and the adoption of referendum debates during the British constitutional crisis: December 1910-August 1911 by David Frederick Ernest Moore A thesis submitted to Plymouth University in partial fulfilment for the degree of MASTER OF PHILOSOPHY School of Law January 2017 Acknowledgements I would like to thank my family and friends for their love and humour. To my mother and father who have supported me in every way. To Dr Vicki Hamlyn, Sally Moss, Paul Stanley QC, Robert Thomas and Suzi Wright I extend my heartfelt gratitude. -
This Work Is Protected by Copyright and Other Intellectual Property Rights
This work is protected by copyright and other intellectual property rights and duplication or sale of all or part is not permitted, except that material may be duplicated by you for research, private study, criticism/review or educational purposes. Electronic or print copies are for your own personal, non- commercial use and shall not be passed to any other individual. No quotation may be published without proper acknowledgement. For any other use, or to quote extensively from the work, permission must be obtained from the copyright holder/s. /' { THE TECHNIQUE AND DEVELOPMENT OF DISRAELI'S NOVELS Dorothy Goldman Ph.D. 1979 ORIGINAL COPY IS TIGHTLY BOUND AND TEXT IS CLOSE TO THE EDGE OF THE PAGE ABSTRACT This thesis reveals how Disraeli adapts and develops fictional techniques. The nature of the less complex of these is defined in Part I, using five early novels. Ch. I establishes a characteristic and recurring trio, the hero, strong woman and sage, and their changing relationships. Ch. II analyses Disraeli's use of "doubles" and symmetry. Ch. Ill describes his literary background with reference to the fashionable novel, psychological study and Byronic influence, and it rejects autobiographical interpretations. Part II considers Disraeli's trilogy. Ch. IV is an analysis of the explicitly political Coningsby, laying particular emphasis on the novel's basic structure (the parallel between Coningsby and the "new" Tory party). Disraeli's incorporation of factual material in his fiction is introduced here. Ch. V. deals with the more socially concerned Sybil, extends the factual/fictional analysis and introduces Disraeli's increasing strength in embodying a novel's central theme - here in its language, in mysteries, misnamings, et al. -
Selected Political Writings
BENJAMIN DISRAELI Selected Political Writings EDITED BY Ishaan H. Jajodia Publisher Publisher Name Location Address Contact © !"!", Ishaan H. Jajodia. ISBN #": ISBN #$: All Rights Reserved. No part of this book may be reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage and retrieval system, without permission in writing from the publisher. ✥ CONTENTS Chronology … iv Introduction … vi A Note on the Texts … xli General Preface to the Longman Collected Edition (#%&#) … # !e Voyage of Captain Popanilla (#%!%) … ## A Vindication of the English Constitution (#%$') … !# First Speech as Member of Parliament (#%$&) … ##' !e Acquirement of Knowledge (#%(() … #!$ Selections from Sybil: or the Two Nations (#%(') … #$' Is Man an Ape or an Angel? (#%)() … !$' An Address to the Working Men of Edinburgh (#%)&) … !'! On Becoming Prime Minister (#%)%) … !)& Conservative Principles: Speech at Manchester (#%&!) … !&! Conservative and Liberal Principles: Speech at Crystal Palace (#%&!) … $"! Inaugural Address as Lord Rector of the University of Glasgow (#%&$) … $#( !e Agricultural Situation (#%&*) … $!' ✥ CHRONOLOGY #%"( Born on !# December to Isaac and Maria D’Israeli in London. #%#& Benjamin D’Israeli was baptised into the Church of England on July $# following a recurring dispute between his father and the Bevis Marks Synagogue; starts at Higham Hall in Epping Forest. #%!# D’Israeli was articled in November to the solicitors Swain, Stevens, Maples, Pearse, and Hunt on the insistence of Isaac D’Israeli. #%!! Benjamin D’Israeli changes his last name to Disraeli. #%!) +e ,rst volume of Vivian Grey is published in April, anonymously, by Henry Colburn. #%!& Disraeli enters his name at Lincoln’s Inn in April. #%!*–$" Writes !e Young Duke. #%$# Disraeli withdraws his name from Lincoln’s Inn; !e Young Duke is published. -
One Hundred Years of Chemical Warfare: Research
Bretislav Friedrich · Dieter Hoffmann Jürgen Renn · Florian Schmaltz · Martin Wolf Editors One Hundred Years of Chemical Warfare: Research, Deployment, Consequences One Hundred Years of Chemical Warfare: Research, Deployment, Consequences Bretislav Friedrich • Dieter Hoffmann Jürgen Renn • Florian Schmaltz Martin Wolf Editors One Hundred Years of Chemical Warfare: Research, Deployment, Consequences Editors Bretislav Friedrich Florian Schmaltz Fritz Haber Institute of the Max Planck Max Planck Institute for the History of Society Science Berlin Berlin Germany Germany Dieter Hoffmann Martin Wolf Max Planck Institute for the History of Fritz Haber Institute of the Max Planck Science Society Berlin Berlin Germany Germany Jürgen Renn Max Planck Institute for the History of Science Berlin Germany ISBN 978-3-319-51663-9 ISBN 978-3-319-51664-6 (eBook) DOI 10.1007/978-3-319-51664-6 Library of Congress Control Number: 2017941064 © The Editor(s) (if applicable) and The Author(s) 2017. This book is an open access publication. Open Access This book is licensed under the terms of the Creative Commons Attribution-NonCommercial 2.5 International License (http://creativecommons.org/licenses/by-nc/2.5/), which permits any noncom- mercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made. The images or other third party material in this book are included in the book's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the book's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. -
Meeting of the Trust Board Friday 23 May 2014 AGENDA
Meeting of the Trust Board Friday 23rd May 2014 Dear Members There will be a public meeting of the Trust Board on Friday 23rd May 2014 at 3:00pm in York House Conference Room, Great Ormond Street, London, WC1N 3JH. Company Secretary Direct Line: 020 7813 8230 Fax: 020 7813 8218 AGENDA Agenda Item Presented by Author STANDARD ITEMS 1. Apologies for absence Chairman Verbal Declarations of Interest All members are reminded that if they have any pecuniary interest, direct or indirect, in any contract, proposed or other matter which is the subject of consideration at this meeting, they must disclose that fact and not take part in the consideration or discussion of the contract, proposed contract or other matter, nor vote on any questions with respect to it. 2. Minutes of Meeting held on 27th March 2014 Chairman J 3. Matters Arising/ Action Checklist Chairman K 4. Interim Chief Executive Report Chief Executive Verbal ANNUAL ACCOUNTS 5. NHS Foundation Trust Final Accounts and Annual Audit Committee L Report 2013-14 including Chair/ Chief Finance Officer/ Company Annual Governance Statement Secretary Code of Governance Head of Internal Audit Opinion 6. Quality Report 2013-14 Co-Medical Director M 7. Annual Report of Audit Committee 2013-14 Chief Finance N Officer STRATEGIC ISSUES 8. Extended Working Update Director of Planning O and Information 9. Outpatient Improvement Project Director of Planning Presentation and Information & Campbell McKerracher, COO Meridian Productivity 10. Update on Referrer work Co-Medical Director Q (CC) 11. Productivity and Efficiency – the new programme Chief Operating Presentation Officer PERFORMANCE 12. -
The Effectiveness of Anti-Corruption Policy
Systematic review The effectiveness of anti-corruption policy What has worked, what hasn’t, and what we don’t know by Professor Rema Hanna Sarah Bishop Sara Nadel Gabe Scheffler Katherine Durlacher July 2011 The EPPI-Centre reference number for this report is 1909. This report should be cited as: Hanna, R., Bishop, S., Nadel, S., Scheffler, G, Durlacher, K. (2011) The effectiveness of anti-corruption policy: what has worked, what hasn‟t, and what we don‟t know–a systematic review. Technical report. London: EPPI-Centre, Social Science Research Unit, Institute of Education, University of London. ISBN: 978-1-907345-14-2 © Copyright Authors of the systematic reviews on the EPPI-Centre website (http://eppi.ioe.ac.uk/) hold the copyright for the text of their reviews. The EPPI-Centre owns the copyright for all material on the website it has developed, including the contents of the databases, manuals, and keywording and data extraction systems. The centre and authors give permission for users of the site to display and print the contents of the site for their own non-commercial use, providing that the materials are not modified, copyright and other proprietary notices contained in the materials are retained, and the source of the material is cited clearly following the citation details provided. Otherwise users are not permitted to duplicate, reproduce, re-publish, distribute, or store material from this website without express written permission. The effectiveness of anti-corruption policy i Contents List of abbreviations .......................................................................... iii Structured abstract ............................................................................ 1 Executive summary ............................................................................ 2 1. Background .................................................................................. 7 1.1 Aims and rationale for review ....................................................... -
British Public Opinion with Regard to Germany
BRITISH PUBLIC OPINION WITH REGARD TO GERMANY 1890 to 1914". - by - Robert Joseph. Boroughs A thesis submitted in partial fulfilment of the requirements for the degree of Master of Apts in the Department/of Historjr. UNIVERSITY 0E BRITISH COLUMBIA October, 19 4 3. 5 TABLE OF CONTENTS Pages Chapter I Public Opinion and The Press. .• 1 - 6A Chapter II Influential Public Opinion 1890-1914- 7 - 13 Chapter III British Foreign Policy 1890-1914. 14 - 29 Chapter IV Expressions of Opinion In Regard To Germany . 30 - 57 Chapter V Public Opinion and Foreign Policy. 58 - 62A Appendix I Bibliographic Notes on the British Press 63-69 Appendix II Key to the Relation between Political and Foreign Policy 1890-1914 ..... 69A- 690- CHAPTER ONE "Public opinion is no more than this, What people think that other people think." Alfred Austin, Prince Lucifer, Act VI, Sc.2 PUBLIC OPINION AND THE PRESS One of the vagaries of our English language is that we may use terms which at once convey to our readers our com• plete Idea and yet while connoting all so hedge our thought with an aura of generality that no tangible impression is made. The term "public opinion" may be considered to be a classic example of such specific vagueness. James Bryce once described public opinion as, " a congeries of all sorts of discrepant notions, beliefs, fancies, prejudices, aspirations. It is confused, incoherent, amorphous, varying from, day to day and week to week."1 We need not be too nonplussed by Lord Bryce's defini• tion, however, for Professor Carroll has defined It simply as "the composite reactions of the general public," This is an.