Welcome Address of the Congress Presidents

Total Page:16

File Type:pdf, Size:1020Kb

Welcome Address of the Congress Presidents Editorial www.anatomy.org.tr doi:10.2399/ana.15.V Welcome Address of the Congress Presidents Anatomy 2015; 9(Suppl 2):V ©2015 Turkish Society of Anatomy and Clinical Anatomy (TSACA) Dear Colleagues, The XXIV ISMS will be hosted by the Turkish Society of Anatomy and Clinical Anatomy in September 02-06, 2015 in Istanbul Although considerably a young society, we are rewarded to have organized the 4th Congress of APICA (Kusadasi – 2005), the 10th Congress of EACA (Istanbul – 2009) and the Joint Meeting of Anatomical Societies (Bursa – 2011) with perfect memories from the attendants of these important meetings. The significance and scope of ISMS lead us to organize this meeting in Istanbul – the extraordinary, proud and mystical city. While attending a high level congress, our participants will also H. Hamdi Çelik Erdo¤an fiendemir have the chance to enjoy the unsurpassable history, charm and beauty of a city of eight thousand years, the capital of three empires, the only city built on two continents, a unique link ing the best invited speakers of the morphological society cer- between East and West, past and present. A place brimming tain enough to ensure you a lifetime experience. with history, Istanbul has modern European infrastructure laced with great palaces, mosques, ancient churches, bazaars and Come to Istanbul, come to the XXIV ISMS! museums. With its perfect location, Istanbul is a city easy to Sincerely, reach by plane, train, car or ship and one of the safest metropo- lises on earth. H. Hamdi Çelik We are promising colorful and exciting social activities, Erdo¤an fiendemir coupled with the breathtaking panorama and exotic surround- Congress Presidents ings of Istanbul, together with a rich scientific program includ- Istanbul, 2015 Committees and Biographies VII Honorary Council Erdogan fiendemir Hakan Hamdi Çelik Professor of Anatomy, Department of Anatomy, Professor of Anatomy, Department of Anatomy, Faculty of Medicine, Uluda¤ University, Bursa, Faculty of Medicine, Hacettepe University, Turkey Ankara, Turkey [email protected] [email protected] Dr. Erdogan Sendemir was born in Bursa, Turkey in 1960. He was Dr. Hakan Hamdi Celik was born in Ankara, Turkey in 1961. He was graduated from Bursa Anatolian High School in 1978 and from Uludag graduated from Ankara University Faculty of Medicine in 1985. He University Faculty of Medicine in 1985. After finishing his obligatory started his doctoral studies at Hacettepe University, Faculty of service in Akhisar, Manisa, he started his specialty in Uludag Medicine, Department of Anatomy in 1988 and received PhD degree University, Medical Faculty, Department of Anatomy in 1988 and gave with his thesis titled “Examination of Dimensions of Ventricular sys- his thesis about "Effects of insulin and/or alfamethylparathyrosine tem by CT” in 1992. After completing his military service, he was injections on thyrosine hydroxylase activity and catecholamine levels in appointed as assistant professor to Hacettepe University, Faculty of the adrenal medulla of rats following hemi- or transection of their Medicine, Department of Anatomy in 1994. He received his associate spinal cords" in 1990. After his military service, he was attended as professor title in 1996. He has been working at the same department as assistant professor at Uludag University, Faculty of Medicine, professor since January 2003. Dr. Celik has more than 100 interna- Department of Anatomy in 1993. In 1994 he spent nine months as a tional publications, more than 150 international presentations in inter- “Visiting Scientist in Department of Brain and Cognitive Sciences, national congresses and more than 600 citations in indexed interna- Massachusetts Institute of Technology (MIT), Cambridge, MA" and tional scientific journals. He has 2 international and 11 national scien- studied in G. Schneider's lab with R.S. Erzurumlu and S. Jhaveri. He tific awards. His scientific fields of interest are neuroanatomy, scanning received his associate professor title in 1997. Between 1999 and 2000, electron microscopy of biologic materials (advanced SEM techniques he continued his research as a "Research Fellow in Louisiana State and anaglyph techniques), radiological anatomy and micro- computer- University (LSU), School of Medicine, Anatomy and Cell Biology ized tomography. Dr Celik is a member of FICSP (Federative Department, New Orleans, LA" for six months with R.S. Erzurumlu. International Committee for Scientific Publications) set up under By 2002 he received his professorship and elected as the head of IFAA (International Federation of Associations of Anatomists) and del- department. He spent two years with G.F. Jirikowski in Friedrich- egate of ICSMS (International Committee of Symposia on Schiller Universitaet (FSU), Anatomie Institut, Anatomie II , Jena as a Morphological Sciences). Dr. Celik was Congress President of EACA visiting scientist in 2003-2005. He has about 20 international publica- 2009 (10th European Congress of European Association of Clinical tions, 25 international presentations in international congresses and Anatomy). Dr. Celik serves as a project consultant for Health Sciences about 40 citations in indexed international scientific journals. He has Research Group and is a panelist of Project Evaluation Committee two international awards. His scientific fields of interest are: under the Scientific and Technological Research Council of Turkey Thalamocortical development, and neural regulation of sympathoad- (TUBITAK). Dr. Çelik has been Deputy Chief Physician of the renal system. Hacettepe Adult Hospitals since 2013. Invited Speakers Sten Grillner ronal circuits - he developed a simpler vertebrate model (lamprey). The (Stockholm–Sweden) different network interneurons, their synaptic interaction (transmitters, receptor subtypes), and their membrane properties (ion channel subtypes Department of Neuroscience, Karolinska Institute, Stockholm expressed) have been identified. The palette of different subtypes of ion channels expressed in different neurones is found to be of critical impor- tance for network function. Through an interaction between detailed multi-faceted experimentation and large scale modelling with biophysi- Sten Grillner is Professor at the Karolinska Institute since 1975 and is a cally realistic numbers of Hodgkin-Huxley neurons, the operation of this member of the National Academy of Science (US), Institute of Medicine entire motor control system has been uncovered. Most recently Sten (US), and several other academies and his awards include The Kavli Prize Grillner has been working on the neural mechanisms underlying selec- in Neuroscience (2008). He is currently Secretary General for IBRO and tion of behaviour using the lamprey as a model, which has had a focus on was President for FENS 2010-2012. Sten Grillner´s research has focused the role of the basal ganglia. A detailed analysis of the connectivity with- on the intrinsic function of the modular network organization underlying in the different parts of the basal ganglia and the habenulae demonstrates fundamental aspects of our motor repertoire. His initial work defined the that it is conserved in considerable detail. Furthermore, transmitters, basic organisation of the mammalian locomotor system in terms of receptor subtypes, and membrane properties, are also maintained from supraspinal command systems, spinal networks coordinating the move- lamprey to mammals. The inference is that the forebrain design with ments (CPGs), and the sensory control of the CPGs. To address the next regard to the basal ganglia and related structures evolved very early in level question - the molecular, cellular and synaptic design of these neu- vertebrate evolution, and has been conserved. Anatomy • Volume 9 / Suppl 2 / September 2015 VIII XXIV International Symposium on Morphological Sciences, 2nd-6th September, 2015, Istanbul, Turkey Reha S. Erzurumlu and University of Virginia Teaching Fellow Award. Her lab is specialized (Baltimore–USA) in track tracing and ultrastructural anatomy approaches to study synaptic circuits in sensory pathways, and synaptic plasticity in developing and Professor of Anatomy and Neurobiology, University aging brains. of Maryland School of Medicine Baltimore, MD, 21201 USA Emel Ulup›nar (Eskiflehir–Turkey) Ph.D. is Professor of Anatomy and Neurobiology and Director of Department of Anatomy, Faculty of Medicine, Medical Neuroscience course at University of Maryland School of Eskiflehir Osmangazi University, Eskiflehir, Turkey Medicine, Baltimore, MD. USA. Professor Erzurumlu received his undergraduate degree from University of Ankara, Turkey, Masters degree from Washington University, St Louis, MO, USA and PhD in biological sciences from University of California, Irvine, CA, USA. He Professor Emel Ulup›nar was born in 1969, in Ankara. After graduation had postdoctoral training at Brown University, Providence, RI, USA and from Gazi University Faculty of Medicine in 1992, she was awarded a Massachusetts Institute of Technology, Cambridge, MA, USA. Professor scholarship for doctoral education by Higher Education Council of Erzurumlu is a member of several professional organizations and he has Turkey. She studied at Cell Biology and Anatomy Department of organized many international meetings and chaired symposia. He is an Louisiana State University Health Sciences Center and received her PhD active member of both the Society for Neuroscience and European degree in 1999. Since then she has been working as a faculty member at Federation
Recommended publications
  • 4 Mechanics of the Cytoskeleton
    4 Mechanics of the cytoskeleton 4.1 Motivation In the previous section, we have seen how biopolymers dynamically assemble and dis- assemble during polymerization. We have discussed the individual mechanical prop- erties such as Young’s modulus E, the axial stiffness EA, the bending stiffness EI, and the persistence length A for individual filaments. In particular, have talked about actin filaments, intermediate filaments, and microtubules. Now, assuming we know the me- chanical properties of the individual filaments, what does that actually tell us about the assembly of filaments that we find in the cell? Or, to put it differently, if we knew elements of the cytoskeleton microtubules intermediate filaments actin filaments Figure 4.1: The cytoskeleton provides structural stability and is responsible for forces during cell loco- motion. Microtubules are thick hollow cylinders reaching out from the nucleus to the membrane, inter- mediate filaments can be found anywhere in the cytosol, and actin filaments are usually concentrated close to the cell membrane. the structural arrangement of filaments, could we then predict the stiffness of the over- all assembly? How does the filament microstructure affect cytoskeletal properties? Or, more precisely, how can we calculate the macroscopic network properties from the in- dividual microscopic filament properties? In mechanics, the derivation of macroscopic parameters based on microscopic considerations is referred to as homogenization. In this chapter, we illustrate the homogenization by means of three different examples, the fiber bundle model for filopodia, the network model for red blood cell membranes, and the tensegrity model for generic cell structures. 4.2 Fiber bundle model for filopodia Filopodia are thin dynamic cytoplasmic projections composed of tight bundles of long actin filaments extending from the leading edge of migrating cells.
    [Show full text]
  • Of Polarity Ups and Downs of Guided Vessel Sprouting
    Ups and Downs of Guided Vessel Sprouting: The Role of Polarity Christina Y. Lee and Victoria L. Bautch Physiology 26:326-333, 2011. doi:10.1152/physiol.00018.2011 You might find this additional info useful... This article cites 82 articles, 38 of which can be accessed free at: /content/26/5/326.full.html#ref-list-1 This article has been cited by 2 other HighWire hosted articles Rasip1 regulates vertebrate vascular endothelial junction stability through Epac1-Rap1 signaling Christopher W. Wilson, Leon H. Parker, Christopher J. Hall, Tanya Smyczek, Judy Mak, Ailey Crow, George Posthuma, Ann De Mazière, Meredith Sagolla, Cecile Chalouni, Philip Vitorino, Merone Roose-Girma, Søren Warming, Judith Klumperman, Philip S. Crosier and Weilan Ye Blood, November 21, 2013; 122 (22): 3678-3690. [Abstract] [Full Text] [PDF] Cas and NEDD9 Contribute to Tumor Progression through Dynamic Regulation of the Cytoskeleton Michael S. Guerrero, J. Thomas Parsons and Amy H. Bouton Genes & Cancer, May , 2012; 3 (5-6): 371-381. [Abstract] [Full Text] [PDF] Downloaded from Updated information and services including high resolution figures, can be found at: /content/26/5/326.full.html Additional material and information about Physiology can be found at: http://www.the-aps.org/publications/physiol on August 25, 2014 This information is current as of August 25, 2014. Physiology (formerly published as News in Physiological Science) publishes brief review articles on major physiological developments. It is published bimonthly in February, April, June, August, October, and December by the American Physiological Society, 9650 Rockville Pike, Bethesda MD 20814-3991. Copyright © 2011 by the American Physiological Society.
    [Show full text]
  • Myth4-FERM Myosin Based Filopodia Initiation
    MyTH4-FERM Myosin based filopodia initiation A DISSERTATION SUBMITTED TO THE FACULTY OF THE GRADUATE SCHOOL OF THE UNIVERSITY OF MINNESOTA BY Ashley L. Arthur IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY Margaret A. Titus, PhD ADVISOR July 2020 © Ashley L Arthur 2020 ACKNOWLEDGEMENTS I would first and foremost like to advisor my mentor, Dr. Margaret Titus, for her unassailable commitment to training, enthusiasm for science and her sup- port of my career. Meg has been superb advisor, has made me a better scientist and communicator and I genuinely enjoyed working for her. I am grateful for the long list of positive experiences and opportunities I gained while working in the Titus lab. I would like to thank all of my past and present lab mates. Thank you to Hilary Bauer, Sinzi Cornea and Zoe Henrot for welcoming me into the lab when I started and especially to Karl Petersen who share his imaging and analysis ex- pertise. I am so grateful for the help and from my PLA project teammate Livia Songster, you brought such great energy to the project and to the lab. Thanks Casey Eddington, Annika Schroeder for their support, encouragement and help reading and discussing many aspect of this work. Thanks to the University of MN undergraduate students who joined my on research projects over the years espe- cially to Himanshu Jain. I would like to thank Jordan Beach at Loyola, Guillermo Marques, Mark Sanders, for their help with imaging. I thank Ashim Rai for his as- sistance with motor purification and motility assays.
    [Show full text]
  • Dynamics of Thin Filopodia During Sea Urchin Gastrulation
    Development 121, 2501-2511 (1995) 2501 Printed in Great Britain © The Company of Biologists Limited 1995 Dynamics of thin filopodia during sea urchin gastrulation Jeffrey Miller1, Scott E. Fraser2 and David McClay1,* 1Developmental, Cell and Molecular Biology, Duke University, SRC, Box 91000, Durham, NC 27708, USA 2Division of Biology, Beckman Institute (139-74), California Institute of Technology, Pasadena CA 91125, USA *Author for correspondence: e-mail [email protected] SUMMARY At gastrulation in the sea urchin embryo, a dramatic involvement in cell-cell interactions associated with rearrangement of cells establishes the three germ layers of signaling and patterning at gastrulation. Nickel-treatment, the organism. Experiments have revealed a number of cell which is known to create a patterning defect in skeleto- interactions at this stage that transfer patterning informa- genesis due to alterations in the ectoderm, alters the normal tion from cell to cell. Of particular significance, primary position-dependent differences in the thin filopodia. The mesenchyme cells, which are responsible for production of effect is present in recombinant embryos in which the the embryonic skeleton, have been shown to obtain ectoderm alone was treated with nickel, and is absent in extensive positional information from the embryonic recombinant embryos in which only the primary mes- ectoderm. In the present study, high resolution Nomarski enchyme cells were treated, suggesting that the filopodial imaging reveals the presence of very thin filopodia (0.2-0.4 length is substratum dependent rather than being primary µm in diameter) extending from primary mesenchyme cells mesenchyme cell autonomous. The thin filopodia provide a as well as from ectodermal and secondary mesenchyme means by which cells can contact others several cell cells.
    [Show full text]
  • 002 Sempozyum1 5 SON.Qxd
    Abstracts www.anatomy.org.tr doi:10.2399/ana.11.001s Abstracts for the Joint Meeting of Anatomical Societies, 19-22 May 2011, Bursa, Turkey Anatomy 2011; 5 Suppl: S1-S171, © 2011 TSACA Opening Lecture New genoarchitectonic viewpoints on the developing hypothalamus Puelles L effects suggests that, rather than being a diencephalic floor ele- ment, the hypothalamus is best understood as a transverse region Department of Human Anatomy, Faculty of lying ventral to the telencephalon and rostral to the dien- Medicine, University of Murcia, Murcia, Spain cephalon; the latter separates it from the midbrain. A number of gene expression patterns observed in the developing forebrain, part of the emergent genoarchitectonic neuroanatomy, have The anatomic concept of the hypothalamus changed consider- revealed the true topologic position of the hypothalamus, as well ably since its earliest definition. Tridimensional reconstructions, as the nature of its fundamental subdivisions. There are interest- experiments and many staining methods have expanded consid- ing parallelisms with genoarchitectonic patterns in the dien- erably the number of anatomical details recognized in this terri- cephalon and midbrain. In all these cases continuous longitudi- tory, probably one of the most complex in the brain. For a long nal domains can be distinguished, as well as a number of antero- time the predominant anatomic view has interpreted the hypo- posterior (transverse) neuromeric units of the neural wall. The thalamus as a longitudinal column at the floor of the dien- hypothalamus has been newly recognized to have two antero- cephalon, connected rostrally with the telencephalon and cau- posterior neuromeric subdivisions, named terminal and pedun- dally with the midbrain.
    [Show full text]
  • Functional Integrity of the Contractile Actin Cortex Is Safeguarded by Multiple Diaphanous-Related Formins
    Functional integrity of the contractile actin cortex is safeguarded by multiple Diaphanous-related formins Christof Litschkoa,1, Stefan Brühmanna,1, Agnes Csiszárb, Till Stephana, Vanessa Dimchevc,d, Julia Damiano-Guercioa, Alexander Junemanna, Sarah Körbera, Moritz Winterhoffa, Benjamin Nordholza,2, Nagendran Ramalingame, Michelle Peckhamf, Klemens Rottnerc,d, Rudolf Merkelb, and Jan Faixa,3 aInstitute for Biophysical Chemistry, Hannover Medical School, 30625 Hannover, Germany; bInstitute of Complex Systems, ICS-7: Biomechanics, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany; cDivision of Molecular Cell Biology, Zoological Institute, Technische Universität Braunschweig, 38106 Braunschweig, Germany; dMolecular Cell Biology Group, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany; eAnn Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115; and fAstbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom Edited by Bruce L. Goode, Brandeis University, Waltham, MA, and accepted by Editorial Board Member Yale E. Goldman January 4, 2019 (received for review December 21, 2018) The contractile actin cortex is a thin layer of filamentous actin, This cortex contains actin, myosin, and associated factors assem- myosin motors, and regulatory proteins beneath the plasma bling into a multicomponent layer (9, 10), which is intimately linked to membrane crucial to cytokinesis, morphogenesis, and cell migra- the membrane in a phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2]- tion. However, the factors regulating actin assembly in this dependent manner by the ezrin, radixin, and moesin (ERM) compartment are not well understood. Using the Dictyostelium family of proteins in animal cells (11, 12) and cortexillin (Ctx) in model system, we show that the three Diaphanous-related for- Dictyostelium (13–15).
    [Show full text]
  • Moesin, a New Cytoskeletal Protein and Constituent of Filopodia: Its Role in Cellular Functions
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector Kidney International, Vol. 41 (1992), pp. 665—670 Moesin, a new cytoskeletal protein and constituent of filopodia: Its role in cellular functions HEINZ FURTHMAYR, WOLFGANG LANKES, and MANUEL AMIEVA Department of Pathology, Stanford University Medical Center, Stanford, California, USA Cell motility, cell attachment and cell-cell interaction arecrombie et al [8, 9], to the analysis of specialized cell attach- basic cellular processes that are of fundamental importancement sites with interference reflection microscopy [10], by during early development, injury and repair responses or in theimmunoelectron and light microscopy, of cell shape by scan- progression of tumors to metastatic disease. Cell movementsning electron microscopy [11, 12], it is clear that much has been often occur over large distances and the cells utilize trackslearned, but these complex processes are still not understood. (substrates) that are frequently modified, such as addition of galactose to laminin by cell surface galactosyl transferase [1] or Moesin is a member of a new family of cytoskeletal proteins proteolysis [2]. The invasion of developing tissues by other cell We have recently cloned and sequenced the complete cDNA types, for example, mesenchymal cells migrating into the ure-of a cellular protein with binding activity for heparin and teral bud [3], presumably involves an invasive phase thatheparan sulfate [13, 14]. We have termed this protein moesin includes: cell-matrix and cell-cell recognition phenomena, cell(membrane organizing extension spike protein, pronounced locomotion, and tissue degradation; a positioning phase of the[moe.ez.in]).
    [Show full text]
  • Modeling Membrane-Protein Interactions
    Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 4 September 2018 doi:10.20944/preprints201809.0055.v1 Peer-reviewed version available at Biomolecules 2018, 8, 120; doi:10.3390/biom8040120 Review Modeling membrane-protein interactions Haleh Alimohamadi and Padmini Rangamani* Department of Mechanical and Aerospace Engineering, University of California San Diego, CA 92093, USA * Correspondence: [email protected]; Tel.: +1-858-534-4734 Abstract: In order to alter and adjust the shape of the membrane, cells harness various mechanisms of curvature generation. Many of these curvature generation mechanisms rely on the interactions between peripheral membrane 1 proteins, integral membrane proteins, and lipids in the bilayer membrane. One of the challenges in modeling these 2 processes is identifying the suitable constitutive relationships that describe the membrane free energy that includes 3 protein distribution and curvature generation capability. Here, we review some of the commonly used continuum elastic 4 membrane models that have been developed for this purpose and discuss their applications. Finally, we address some 5 fundamental challenges that future theoretical methods need to overcome in order to push the boundaries of current model 6 applications. 7 8 Keywords: Plasma membrane; Spontaneous curvature; Helfrich energy; Area difference elastic model; Protein crowding; Deviatoric curvature 9 10 11 1. Introduction 12 The ability of cellular membranes to bend and adapt their configurations is critical for a variety of cellular functions 13 including membrane trafficking processes [1,2], fission [3,4], fusion [5,6], differentiation [7], cell motility [8,9], and signal 14 transduction [10–12]. In order to dynamically reshape the membrane, cells rely on a variety of molecular mechanisms from 15 forces exerted by the cytoskeleton [13–15] and membrane-protein interactions [16–19].
    [Show full text]
  • Universidad Nacional De Córdoba Facultad De Ciencias Médicas
    UNIVERSIDAD NACIONAL DE CÓRDOBA FACULTAD DE CIENCIAS MÉDICAS TRANSICIÓN EPITELIO-MESENQUIMÁTICA RENAL EN UN MODELO EXPERIMENTAL DE HIPERURICEMIA: PARTICIPACIÓN DE NALP-3 Y SUS FUNCIONES CANÓNICAS Y NO-CANÓNICAS Trabajo de Tesis para optar al Título de Doctor en Medicina y Cirugía Médico Cirujano Cesar Andrés Romero CÓRDOBA REPÚBLICA ARGENTINA 2014 1 COMISIÓN DE SEGUIMIENTO DE TESIS Director: Prof. Dr. Jorge H. Mukdsi Prof. Adjunto del Centro de Microscopía Electrónica. Facultad de Ciencias Médicas. Universidad Nacional de Córdoba. Integrantes: Prof. Dr. Luis I. Juncos Prof. Consulto de la Facultad de Ciencias Médicas. Universidad Nacional de Córdoba. Prof. Dr. Rodolfo E. Ávila Prof. Adjunto de la Cátedra de Biología Celular, Histología y Embriología. Facultad de Ciencia Médicas. Universidad Nacional de Córdoba. 2 Artículo 30º del Reglamento de la Carrera de Doctorado en Medicina y Cirugía “LA FACULTAD DE CIENCIAS MÉDICAS NO SE HACE SOLIDARIA CON LAS OPINIONES DE ESTA TESIS” 3 El presente trabajo de investigación se ha realizado en el Centro Microscopía Electrónica de la Facultad de Ciencias Médicas de la Universidad Nacional de Córdoba, de acuerdo con la reglamentación vigente en la Facultad de Ciencias Médicas de la Universidad Nacional de Córdoba para optar al título de Doctor en Medicina y Cirugía. Durante la ejecución, el autor fue Profesor Asistente del Centro de Microscopía Electrónica y contó con el apoyo financiero de subsidios del SECyT, CONICET, y FONCYT, otorgados al Centro de Microscopía Electrónica. 4 A mi esposa e hijas. A mis padres. A mis maestros. 5 AGRADECIMIENTOS Quiero expresar mis agradecimientos a la Prof. Dra. Alicia Inés Torres, Directora del Centro de Microscopía Electrónica por darme la posibilidad de realizar mi tesis doctoral y por brindarne su apoyo y consejo en todo momento.
    [Show full text]
  • Citocinas Proinflamatorias: Participación En La Modulación De La Actividad Del Melanoma Experimental B16
    eman ta zabal zazu Universidad Euskal Herriko del País Vasco Unibertsitatea MEDIKUNTZA ETA ODONTOLOGIA FAKULTATEA FACULTAD DE MEDICINA Y ODONTOLOGIA Dpto. de Biología Zelulen Biologia Celular e Histología eta Histologia Saila CITOCINAS PROINFLAMATORIAS: PARTICIPACIÓN EN LA MODULACIÓN DE LA ACTIVIDAD DEL MELANOMA EXPERIMENTAL B16 Por: Juan Carlos de la Cruz Conde Licenciado en Ciencias Biológicas LEIOA, 2014 Mi más sincero agradecimiento, A la Dra. Alicia García de Galdeano, directora de este trabajo por su sinceridad, apoyo, orientación, dedicación y estímulo permanente; pero sobre todo, por la confianza que depositó en mí para la realización del mismo. La aventura que iniciamos está a punto de terminar. Juntos recorrimos todo este camino y a pesar de las adversidades, ha merecido con mucho la pena aprender y trabajar colaborando contigo en este grupo. A los Profesores Mª Luz Cañavate, Juan Aréchaga, Mª Dolores Boyano, Antonia Álvarez, Francisco José Sáez, Fernando Unda, Enrique Hilario, Gorka Pérez-Yarza, Jon Arlucea, Carmen de la Hoz y Noelia Andollo, por todas las facilidades recibidas a lo largo de la realización de esta Tesis. Entre otras: la cesión de locales y el uso de equipos técnicos (citometría de flujo y microscopía de fluorescencia) e informáticos. Por su asesoramiento científico y haber puesto a mi disposición bibliografía. Así como, material de laboratorio de todo tipo, tanto fungible como diversos productos. Además, quiero hacer mención especial al Dr. Manuel García Sanz, que aunque ya no este físicamente, nos brindó su colaboración desinteresada y del que siempre obtuvimos todo tipo de facilidades y atenciones. A mis Amigos que forman parte del Departamento de Biología Celular e Histología, en especial a Loli García Vázquez, la persona que me enseñó con cariño y paciencia infinita.
    [Show full text]
  • The Co-Workers of Actin Filaments: from Cell Structures to Signals
    FOCUS ON CYTOSKELETAL DYNAMICS THE CO-WORKERS OF ACTIN FILAMENTS: FROM CELL STRUCTURES TO SIGNALS Céline Revenu, Rafika Athman, Sylvie Robine and Daniel Louvard Cells have various surface architectures, which allow them to carry out different specialized functions. Actin microfilaments that are associated with the plasma membrane are important for generating these cell-surface specializations, and also provide the driving force for remodelling cell morphology and triggering new cell behaviour when the environment is modified. This phenomenon is achieved through a tight coupling between cell structure and signal transduction, a process that is modulated by the regulation of actin-binding proteins. PHAGOCYTOSIS The integrity of the actin cytoskeleton is essential for cells networks that support cellular specializations, and then An actin-dependent process by to form and maintain their shape and structure. The focus on the ABPs that are implicated in these networks, which cells engulf external remodelling of the cytoskeleton in dynamic cellular illustrating their roles and regulation both in actin orga- particulate material by extension processes produces changes in cell shape and motility in nization and in the integration of signals that lead to and fusion of pseudopods. response to external stimuli, and is therefore involved actin dynamics (BOX 1). MICROVILLI in signal transduction. These features of the actin Small, finger-like projections cytoskeleton are regulated by a cohort of actin-binding Surface specializations and underlying networks (1–2 µm long and 100 nm wide) proteins (ABPs), which were initially considered to be Differentiated cells have morphological features that cor- that occur on the exposed structural components that organize a stable actin relate with their specialized functions in the organs and surfaces of epithelial cells to maximize the surface area.
    [Show full text]
  • Fascin in Cell Migration: More Than an Actin Bundling Protein
    biology Review Fascin in Cell Migration: More Than an Actin Bundling Protein Maureen C. Lamb and Tina L. Tootle * Anatomy and Cell Biology Department, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; [email protected] * Correspondence: [email protected] Received: 23 October 2020; Accepted: 13 November 2020; Published: 17 November 2020 Simple Summary: Cell migration is an essential biological process that regulates both development and diseases, such as cancer metastasis. Therefore, understanding the factors that promote cell migration is crucial. One of the factors known to regulate cell migration is the actin-binding protein, Fascin. Fascin is typically thought to promote cell migration through bundling actin to form migratory structures such as filopodia and invadapodia. However, Fascin has many other functions in the cell that may contribute to cell migration. How these novel functions promote cell migration and are regulated is still not well understood. Here, we review the structure of Fascin, the many functions of Fascin and how they may promote cell migration, how Fascin is regulated, and Fascin’s role in diseases such as cancer metastasis. Abstract: Fascin, an actin-binding protein, regulates many developmental migrations and contributes to cancer metastasis. Specifically, Fascin promotes cell motility, invasion, and adhesion by forming filopodia and invadopodia through its canonical actin bundling function. In addition to bundling actin, Fascin has non-canonical roles in the cell that are thought to promote cell migration. These non-canonical functions include regulating the activity of other actin-binding proteins, binding to and regulating microtubules, mediating mechanotransduction to the nucleus via interaction with the Linker of the Nucleoskeleton and Cytoskeleton (LINC) Complex, and localizing to the nucleus to regulate nuclear actin, the nucleolus, and chromatin modifications.
    [Show full text]