PROGRAM 2018 Annual Forum Bigger, faster & better: enabling the next era of translational medical research Wednesday 29th August 2018 The Partnership Welcome to the 2018 Annual Forum

When Health Partners held its first There is increasing recognition amongst forum in May 2015 it was an idea whose time our members that SHP offers a potential had come. pathway to achieving reforms which might previously have been considered too hard. Along with the three other newly-accredited Advanced Health Research and Translation In addition, there is the potential for more Centres in , SHP was a response rapid research translation in the form of to the growing requirement to remove or 14 projects we’ve supported with Medical reduce the long-standing barriers impeding Research Future Fund grants. Progress is translation of medical discoveries into promising and we are looking forward to clinical practice. their reported outcomes at the end of the year. In discussions we developed a challenging goal: by working with our partner Local Meanwhile, we’ve been heartened by the Health Districts, independent medical volume and quality of applications we’ve research institutes and the University received for the next funding round. Our of Sydney, could we achieve the greater ability to support further research projects mobility of people, funds and data we was confirmed in June, when the Federal believed was required to more quickly Government announced that Sydney Health deliver the outcomes of research to our Partners would receive a further $6.1 million patients? over three years. Its support for SHP and the other AHRTCs allows us all to proceed with In 2018 we have been working towards this confidence - both individually and as the goal by sharpening our focus on six key Australian Health Research Alliance - into areas which influence research translation. 2019 and beyond. We’ve applied resources to projects which variously aim to enable the sharing and use Thank you for taking the time to attend of data, streamline ethics and governance, our Annual Forum. To bring so many key consolidate and improve the use of bio- individuals and organisations together in banking, increase consumer and community the cause of research translation is a rare involvement, build clinical trials skills opportunity and one I know we will all and capacity and foster the discipline of embrace. implementation science to facilitate change. There’s a lot going on, and this scale up of activity has only been possible thanks to the continued enthusiastic support and Professor Garry Jennings AO engagement of everyone in our Partnership. Executive Director, Sydney Health Partners Annual Forum Program Bigger, faster & better: enabling the next era of translational medical research

Wednesday 29th August 2018

1.00pm Forum Registration Lorimer Dods Theatre Foyer, Children’s Hospital, Westmead

1.30pm - 3.00pm SESSION 1

1.30pm Welcome & Introduction to Professor Kathryn North AM Professor Garry Jennings AO, Executive Director, Sydney Health Partners

1.45pm “Genomics and the Brave New World of Personalised Medicine: A Global and Local Perspective” Professor Kathryn North AM, Director, Murdoch Children’s Research Institute

2.15pm Introduction to Mr Peter Wills AC Mr Paul McClintock AO,Chair, Governing Council, Sydney Health Partners

“The Biomedical Translation Fund: Crossing the “Valley of Death” from Research to Market” Mr Peter Wills AC, Chair, Biomedical Translation Fund Committee, Innovation Science Australia

2.35pm Panel Discussion: The Science of Implementing Change in a Clinical Setting CHAIR: Dr Teresa Anderson AM, Chief Executive, Sydney Local Health District Panel Members: Dr Jean-Frédéric Levesque, Chief Executive, Agency for Clinical Innovation Professor Adrian Bauman, Professor of Public Health, The Professor Andrew Wilson, Co-Director, Menzies Centre for Health Policy Professor Kathryn North AM, Director, Murdoch Children’s Research Institute 3.00pm Afternoon Tea

3.20pm - 5.10pm SESSION 2

3.20pm Panel Discussion: Improving the Process of Ethics and Governance CHAIR: Professor Roger Reddel, Director, Children’s Medical Research Institute P anel Members: Associate Professor Geoffrey Herkes, Senior Staff Specialist, Northern Sydney Local Health District James Cokayne, Human Research Ethics and Governance, NSW Office for Health and Medical Research Helene Abouyanni, Director of Operations, Research and Education Network, Western Sydney Local Health District Dr Lesley Ashton, Executive Director Research Operations, Coordination & Systems Planning, The University of Sydney Annual Forum Program Bigger, faster & better: enabling the next era of translational medical research

3.45pm Panel Discussion: Achieving Better Consumer and Community Involvement CHAIR: Dr Michael Brydon, Chief Executive, Sydney Children’s Hospitals Network Westmead P anel Members: Jo Root, Policy Director, Consumers Health Forum of Australia Karen Carey, Chair, NHMRC Community & Consumer Advisory Group Professor Juanita Sherwood, Academic Director, National Centre for Cultural Competence, The University of Sydney Dr Coralie Wales, Manager of Community and Consumer Partnerships, Western Sydney Local Health District 4.10pm Panel Discussion: Building Capacity and Recruitment for Clinical Trials CHAIR: Mr. Danny O’Connor, Chief Executive, Western Sydney Local Health District P anel Members: Associate Professor Rachael Morton, Director of Health Economics, NHMRC Clinical Trials Centre Professor Vlado Perkovic, Executive Director, The George Institute, Australia Associate Professor Judith Trotman, Director, Haematology Clinical Research Unit, Concord Hospital 4.35pm Panel Discussion: Harmonising and Sharing Data between Districts and Institutes CHAIR: Professor Laurent Rivory, Pro-Vice-Chancellor (Research), The University of Sydney P anel Members: Professor Tim Shaw, Director of Research in Implementation Science and eHealth, The University of Sydney Dr Diane Watson, Chief Executive, Bureau of Health Information Dr Zoran Bolevich, Chief Executive & CIO, eHealth NSW 5.00pm Closing Remarks Professor Garry Jennings AO, Executive Director, Sydney Health Partners Mr Paul McClintock AO, Chair, Sydney Health Partners 5.10pm – 6.30pm Forum Networking Drinks Keynote Speakers & Presenters

Professor Kathryn North AM Mr Peter Wills AC Director of the Murdoch Children’s Research Chair, Biomedical Translation Fund Institute Committee Co-Deputy Chair, National Genomics Future Innovation and Science Australia Mission In June 1996, Mr Wills was appointed Chair of NHMRC’s Research Committee as a Member in the General Division Professor Kathryn North AM is Director of of the Order of Australia for service to the Murdoch Children’s Research Institute the community. In June 2001, he was and the David Danks Professor of Child appointed as a Companion in the General Health Research at the University of Division of the Order of Australia for service Melbourne. to social and economic advancement through the development of public policy Professor North is trained as a physician, in relation to biomedical research and neurologist and clinical geneticist and biotechnology. was awarded a doctorate for research in neurogenetics. She completed a In 1996, Mr Wills chaired the committee, postdoctoral fellowship in the Harvard formed by the Minister for Health and Genetics Program. Aged Care, Dr Michael Wooldridge, which took on the task of assessing Australia’s Professor North is a national and health and medical research. The Wills international leader in Genomic medicine. report was released in 1999 and was In 2014, she was appointed as Vice Chair instrumental in bringing medical research of the Global Alliance for Genomics and to the attention of the media and increasing Health – a collaborative network of over funding for Australian science. This report: 500 organisations across over 70 countries. The Virtuous Cycle: Working Together for Commencing in 2016, she leads an Health and Medical Research lead directly NHMRC-funded national network of over to the formation of Research Australia and 80 institutions - the Australian Genomics Mr Wills remains an active and important Health Alliance. member of the Research Australia board, of which he is Deputy Chair. Professor North has received a number of awards including the GSK Australia Mr Wills was also appointed a member of Award for Research Excellence (2011), The Biotechnology Consultative Group the Ramaciotti Medal for Excellence in formed in 1999, to advise Biotechnology Biomedical Research (2012) and Member Australia and the Commonwealth of the Order of Australia (AM) for service to Biotechnology’s Ministerial Council on the medicine in the field of neuromuscular and development of the National Biotechnology neurogenetics research (2012). She chaired Strategy. In 2002 Mr Wills retired as NHMRC Research Committee (2012-2018) Chairman of the Australian Research and International Advisory Board of the Council. He has been Chairman of the Great Ormond Street Institute of Child Garvan Institute of Medical Research, Health (UK) and is a member of the Board Chairman of the Australian Research of the Victorian Comprehensive Cancer Council and also contributed to the Centre. National Biotechnology Strategy. In 2001 Mr Wills served on the committee, Chaired by Chief Scientist Dr Robin Batterham, Alfred Medical Research and Education which lead to the Federal Government’s precinct. As a researcher, his interests Innovation Statement include the prevention and treatment of cardiovascular disease. In 2011/12, Mr Wills chaired the NSW Health & Medical Research Review for Professor Jennings was appointed an the NSW State Government. The Review Officer of the Order of Australia in 2013 assessed the current performance of for his service to medical research and the health and medical research in NSW, prevention and control of cardiovascular made recommendations on how the sector disease, obesity and diabetes. can be improved, better coordinated and leveraged; and proposed ways in which the NSW health needs, clinical trials and commercialisation capacity can be better supported or expanded. The majority of the recommendations were accepted by the NSW Government. Mr Wills and has a background in Mr Paul McClintock AO architecture, business and local Chair, Governing Council, Sydney Health government prior to his involvement in the Partners health and medical research sector. Paul McClintock AO has vast experience in both the public and private sectors with a strong interest in health organisations. From July 2000 to March 2003 Mr McClintock served as the Secretary to Cabinet and head of the Cabinet Policy Unit reporting directly to the Prime Minister. He is currently the Chair of NSW Ports and the Professor Garry Jennings AO national President of the Committee for Executive Director, Sydney Health Partners Economic Development of Australia. Professor Garry Jennings AO is the In the health sector he is an honorary Executive Director of Sydney Health fellow of the and Partners and has extensive experience in the Woolcock Institute of Medical Research health and medical research, specialising and holds ongoing leadership roles in St in cardiology. He served as the Director of Vincent’s Health Australia, I-MED and The Baker IDI Heart and Diabetes Institute in George Institute. Melbourne for 14 years and most recently as the Interim CEO of the National Heart Foundation. He has had a long association with the National Heart Foundation as a former Board Member and Chair of its Cardiovascular Health Advisory Committee. As a leading cardiologist, Professor Jennings has also had a long career in clinical practice including as the Director of Cardiology at The Alfred Hospital, Melbourne. Professor Jennings also played a key role in the transformation of The Alfred campus as Foundation Chair of the Our Panel Chairs

Dr Teresa Anderson AM Professor Roger Reddel Chief Executive, Sydney Local Health Director, Children’s Medical Research District Institute Dr Anderson has more than 30 years’ Professor Reddel has been Director of experience as a clinician and health service Children’s Medical Research Institute executive. Her roles included General (CMRI), and the Sir Lorimer Dods Professor, Manager, Liverpool Hospital and Director, Sydney Medical School, University of Clinical Operations, Former Sydney South Sydney, since 2007. He is also Head of West Area Health Service. CMRI’s Cancer Research Unit, Director of CellBank Australia and Co-Director of She as a well-established reputation ProCan®. for implementing strategies to foster innovation and best practice, supporting After obtaining his medical degrees from collaboration and building partnerships, the University of Sydney and training in to provide excellent health care to almost medical oncology at Royal Prince Alfred 700,000 people living within SLHD and Hospital, Professor Reddel completed a beyond. PhD in cancer cell biology at the Ludwig Institute for Cancer Research and undertook Dr Anderson is a speech pathologist, postdoctoral research at the National internationally recognised for her Cancer Institute, Bethesda, in the United specialist knowledge and skills in research, States. assessment and management of paediatric and adult dysphagia, early communication Professor Reddel is internationally development, early childhood development recognised for research on the enzyme and early intervention. telomerase and for discovering ALT (Alternative Lengthening of Telomeres), In addition to serving on both the which together contribute to unlimited Governing Council and the Executive growth in over 95 per cent of cancers. Management Committee of Sydney Health Partners, Dr Anderson is a member of nine Professor Reddel was elected as a Fellow medical research and PHN boards. of the Australian Academy of Science in 2010 and received the NSW Premier’s Award for Outstanding Cancer Researcher of the Year 2011. He has also been awarded the Neil Hamilton Fairley Medal of the Royal Australasian College of Physicians the Ramaciotti Medal for Excellence in Biomedical Research. Danny currently serves on the Boards of the Western Sydney Local Health District Board (ex-officio), Westmead Millennium Institute, NSW HealthShare, Westmead Medical Research Foundation and WentWest Primary Health Network. Dr Michael Brydon Chief Executive, Sydney Children’s Hospitals Network Westmead Dr Michael Brydon was permanently appointed to the role of Chief Executive of the Sydney Children’s Hospitals Network in July 2016, having previously served as the Acting Chief Executive and Director of Professor Laurent Rivory Clinical Operations. Pro-Vice-Chancellor (Research), The Prior to the Network forming, Dr Brydon University of Sydney worked at the Sydney Children’s Hospital, Professor Rivory has 20 years’ experience Randwick for 27 years. In the last two in research and leadership, which has decades, he has established a wide network spanned the higher education, hospital of personal partnerships, predominantly in and industry sectors. He is widely the child health environment and gained recognised for his research in cancer drug significant expertise in clinical management pharmacology through appointments at and medical administration. Ever since the University of Queensland, the Royal entering paediatrics, Michael has advocated Prince Alfred Hospital, the Université de for children and their families, highlighting Bordeaux II and the Fondation Bergonié, the differences in their needs and ensuring and the University of Sydney. Professor a fair allocation of resources to paediatrics. Rivory also served as Senior Research Director, Research and Development, at Johnson and Johnson Research and was most recently Director of the Research Strategy Office at the University of . As PVC (SC&P), Professor Rivory’s responsibilities include the large-scale Mr Danny O’Connor collaborations such as the Charles Perkins Chief Executive, Western Sydney Local Centre and the Brain and Mind Centre, Health District the Core Research Facilities and the Danny was appointed chief executive of management of external partnerships, the Western Sydney Local Health District particularly in health. He has a strong (WSLHD) in January 2011. He believes interest in ensuring that these enable the primary purpose of healthcare is to increased scale and translation of health improve people’s lives. Central to success research at the University of Sydney. is a strong partnership with consumers in continually improving the services we provide. Likewise, strong partnership is required between science and practice to ensure the continuous evolution of best practice in clinical care and population health programs. 2018 RART Project Funding

In 2018, the following Rapid Applied Research Translation (RART) projects received one-year grants in from Sydney Health Partners, using money provided by the Medical Research Future Fund. Posters for these projects can be viewed on TV screens adjacent to the Lorimer Dods Theatre.

Dr Sarah Maguire Dr Dinny Graham SYDNEY LOCAL HEALTH DISTRICT WESTERN SYDNEY LOCAL HEALTH S Madden, M Cunich DISTRICT The implementation of an evidence-based C Clarke, P Dinh, E Elder, N Pathmanathan treatment in the hospital-to-community Affordable genomic testing for improved pathways for children & adolescents with breast cancer outcomes in disadvantaged anorexia nervosa. Australian populations.

Associate Professor Angela Webster Professor David Hunter WESTERN SYDNEY LOCAL HEALTH NORTHERN SYDNEY LOCAL HEALTH DISTRICT DISTRICT K Sud, E O’Lone, K McCaffery, H Shepherd, OAChangeMap: D Muscat Moving from best practice models Supporting culturally-diverse adults with of osteoarthritis care to system level Chronic Kidney Disease to engage in implementation and impact. shared decision making successfully.

Professor Jacob George Professor Barbara Fazekas de St Groth WESTERN SYDNEY LOCAL HEALTH SYDNEY LOCAL HEALTH DISTRICT DISTRICT S Kao, S Clarke, N Pavlakis, R Hui, D G McCaughan Karikios Maximising Cures for HCV in Marginalised Predicting response to checkpoint therapy Communities - e.g., those with a in lung cancer. These therapies are history of injecting drug use, and other expensive and can induce severe immune- disadvantaged socioeconomic groups. related adverse events so there is an urgent unmet need to predict which patients are likely to respond. Professor Jonathan Morris NORTHERN SYDNEY LOCAL HEALTH DISTRICT Does real time data reduce clinical variation and improve patient outcome in acute chest pain? Professor Madeleine King Professor Tim Shaw SYDNEY LOCAL HEALTH DISTRICT WESTERN SYDNEY LOCAL HEALTH M Tinsley, C Rutherford, R Speerin, A DISTRICT Butcher, L Soars C Kielly-Carroll, A Janssen Enablers and barriers to implementing Using EHR data to drive translation of patient reported measures to improve evidence into practice and improve cancer patient self-management and behaviour care provided by teams and individuals. change, clinical care and health services.

Professor Jonathan Morris Professor Nicholas Wood NORTHERN SYDNEY LOCAL HEALTH SYDNEY CHILDRENS HOSPITAL NETWORK DISTRICT (WESTMEAD) M Nicholl, T McGee, I Alahakoon, T Nippita, T McGee, S Chua, M Nicholl, R Ogle, J J Ford Hyett Are we there yet? Optimising timing Efficacy and safety of vaccination in“at of planned birth to improve newborn risk” pregnant women and impact on infant outcomes and reduce health service costs. immune responses to vaccines.

Professor Clara Chow Professor Robyn Jamieson WESTERN SYDNEY LOCAL HEALTH SYDNEY CHILDRENS HOSPITAL NETWORK DISTRICT (WESTMEAD) G Figtree, L Kritharides Genomic Eye Medicine Initiative - translate Cardiology Rapid Access Clinics - an genomics testing for genetic eye disease outpatient management pathway for developed through research into the clinical patients presenting to Emergency setting at four participating hospitals. Department with chest pain, providing quick evaluation, investigations and management in a specialised outpatient Professor Sarah Hilmer setting. NORTHERN SYDNEY LOCAL HEALTH DISTRICT D Le Couteur Polypharmacy in the Elderly - develop and provide information for patients and caregivers at discharge from acute geriatric services about ceasing to use inappropriate medications identified during their hospital stay. Sydney Health Partners’ research translation is structured around nine clinical streams and six cross-cutting themes, each led by senior researchers and clinicians from across the Partnership.

Clinical Stream Leads Cancer Roger Reddel [email protected] Cardiovascular Clara Chow [email protected] Gemma Figtree [email protected] Len Kritharides [email protected] Infectious Diseases Tania Sorrel [email protected] Warwick Britton [email protected] Liver Jacob George [email protected] Geoff McCaughan [email protected] Mental Health Tim Lambert [email protected] Neuroscience Matthew Kiernan [email protected] Craig Anderson [email protected] Renal Carol Pollock [email protected] Vlado Perkovic [email protected] Jeremy Chapman [email protected] Musculoskeletal David Hunter [email protected] Chris Maher [email protected] Joshua Burns [email protected] Respiratory Carol Armour [email protected] Jennifer Alison [email protected] Cross Cutting Theme Leads Biobanking Christine Clarke [email protected] Clinical Trials Simon Finfer [email protected] Judith Trotman [email protected] Implementation Don Nutbeam [email protected] Science & Education* Nicole Rankin [email protected] Genomics Robyn Jamieson [email protected] Informatics & eHealth Jonathan Morris [email protected] Tim Shaw [email protected] Research Enablers Lesley Ashton [email protected]

*Theme under development Acknowledgements The 2018 Annual Forum Committee would like Mr Danny O’Connor, Professor Roger Reddel to acknowledge everyone who contributed and Professor Laurent Rivory. to the success of this event. We would like to To all our panel members for their enthusiasm acknowledge the Traditional Owners of the land in sharing their knowledge and insights with on which we meet today. We would also like to us; and to all our partner organisations for their pay respect to the Elders both past and present. strong and continued support. We would especially like to thank the Chair of Finally, thank you to everyone who attended Sydney Health Partners Mr Paul McClintock AO, this event to learn more about Sydney Health and keynote speakers Professor Kathryn North Partners and the world-class research being AM and Mr Peter Wills AC. Our Session Chairs conducted across our partnership. Dr Teresa Anderson AM, Dr Michael Brydon,

Level 3, The Hub T: +61 2 8627 5452 Charles Perkins Centre (D17) www.sydneyhealthpartners.org.au The University of Sydney E: [email protected] NSW 2006