A Novel Wound and Soft Tissue Flap Negative Pressure Drain System - a Pilot Study Steven D
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Archives of Health Science Research Article A Novel Wound and Soft Tissue Flap Negative Pressure Drain System - a Pilot Study Steven D. Jones Jr MD*1, Parker J. Prusick MD1, Bennie G. Lindeque MD PhD1 1Department of Orthopedic Surgery, University of Colorado Denver, 12631 E 17th Ave, Aurora, CO 80045, USA *Corresponding Author: Steven D. Jones Jr MD, Department of Orthopedic Surgery, University of Colorado Denver, 12631 E 17th Ave, Aurora, CO 80045, USA Abstract Background: Negative-pressure wound-therapy (NPWT) has become a mainstay of treatment for high-risk surgical wounds. In closed wounds, traditional NPWT utilizes surface level sponges alone to provide negative pressure. A technique that allows for deep dead-space management, while maintaining superficial negative pressure over a closed wound, may prove beneficial inhigh-risk patients. Purpose: A novel technique and prospective case series are described which incorporate deep hemovac drain tubings into a traditional NPWT device (Deep Inside-Out Vac; DIOV). Pilot data is needed to begin evaluating the efficacy of this technique. Methods: Fourteen patients were stratified by initial indication for DIOV placement. Group 1 patients underwent wide tumor resection, while Group 2 patients underwent extensive debridement for infection. Demographic, surgical, and microbiological data were recorded. Results: Eight patients were identified in Group 1. Six were identified in Group 2. Both demonstrated 50% positive culture rates at time of drain removal. Most common organisms were coagulase negative staphylococcus species. At final follow-up, all wounds were clinically healed. Conclusions: NPWT is an established augment in post-operative wound care. The DIOV may provide added benefit in wounds at high-risk for dead-space related complications. Contamination remains unfavorable, and further research is needed to determine this device’s efficacy. Level of Evidence: Level IV Introduction surgical site infections compared to treatment with standard surgical dressings Background (8.8% vs 13.0% in the standard dressing Negative-pressure wound-therapy group; relative risk 0.66) [18]. Surgical site (NPWT) has become a mainstay of infections are a common complication and treatment for complex and high-risk are known to increase patient morbidity surgical wounds over the last three decades. and substantially increase health care Orthopedic and General Surgical related costs. A 2009 systematic review subspecialties alike have utilized these found that surgical site infections often systems to improve wound healing and double healthcare costs, primarily due to decrease morbidity in select patients. A increased lengths of stay [4]. Techniques to recent 2020 Cochrane meta-analysis of over reduce these complications have been 40 randomized controlled trials (RCTs) studied extensively and numerous demonstrated with moderate-certainty modalities have been explored over recent evidence that NPWT results in fewer years. Archives of Health Science 1 A Novel Wound and Soft Tissue Flap Negative Pressure Drain System - a Pilot Study Traditional NPWT was first utilized drain hemovac tubing into traditional in the early to mid-1990s. The first NPWT over a closed surgical wound. The indications for these devices included open construct was termed the Deep Inside-Out fractures and chronic, high-risk, lower Vac (DIOV) and was designed to further the extremity wounds [9, 2]. As techniques and depth of dead-space management while technology have advanced, NPWT has preserving the benefits of negative pressure become a safe and established method for over a closed wound. Pilot data from culture improving surgical site related outcomes in results at time of DIOV removal was select patients [1, 14, 15]. The cost assessed to determine if this technique effectiveness of NPWT remains controversial, maintains the device as a closed, aseptic, though many studies have found it to be sealed system. cost-neutral, if not cost saving, in a majority of applications [12, 16, 28]. NPWT has Methods become a fundamental component of high- Approval from the University of risk surgical wound management at Colorado School of Medicine Institutional numerous academic institutions. Review Board was obtained for this Rationale prospective case series. The cases and In orthopedic oncology, dead-space subsequent microbiological analyses were management is a critical component of conducted at a single institution. All surgical success for wound healing. Wide-resections procedures were performed by a single, for tumor removal often create soft tissue board-certified, fellowship-trained cavities that are prone to seroma and orthopedic oncologic surgeon (author BL). hematoma formation. This concept also This author also serves as a bone sepsis and rings true in infectious cases requiring musculoskeletal infection specialist at the extensive debridement. Significant tissue manuscript’s host institution. loss for any reason(whether surgical, Device Components and Terminology infectious, or traumatic) can create a negative pressure void prone to adverse The NPWT system used included a fluid accumulation. V.A.C.™ device (Vacuum Assisted Closure; K.C.I. Licensing, Inc., San Antonio, TX) with Literature dating back to the 1940s black polyurethane ether sponges. The established that dead-space management is hemovac tubing was taken from standard a crucial component of post-operative 1/4th inch DAVOL drum-style drains wound success [21]. Post-operative seroma (Medivida Corp. International, Causeway and/or hematoma formation can place Bay, HK), which were packaged and opened unyielding pressure on overlying tissues sterilely at time of placement. The term and may increase the risk of wound “hemovac,” when used in this manuscript dehiscence [19]. NPWT has been proven to represents any blub- or drum-style closed be beneficial for dead-space management in suction drain that relies on stored potential both human and animal models [23, 24]. energy to maintain negative pressure across For superficial tissues, incisional NPWT its system. While there is colloquial use of devices alone are often adequate to prevent this term, it should be known that the term post-operative, fluid-related complications. HEMOVAC is a registered trademark of However, in deeper areas of dead-space Zimmer Biomet Holdings, Inc. (Warsaw, IN), (particularly in the thigh, groin, or in and would represent one specific brand of morbidly obese patients), superficial NPWT “hemovac” drain device. The preliminary alone may not be sufficient to mitigate the design for the DIOV comes from risks associated with deep space fluid Christopher J. Kleck MD at the University of accumulation. A technique that allows for Colorado School of Medicine. The device’s deep dead-space management, whilst initial use was for complex wound simultaneously maintaining negative management following spinal surgery. pressure over a closed wound, may provide added benefit in select patients at high-risk Patients and Indications for dead-space related complications. Fourteen patients were identified In this case series, we describe a and prospectively enrolled in this pilot novel technique for incorporating deep analysis. Patients were included if they Archives of Health Science 2 A Novel Wound and Soft Tissue Flap Negative Pressure Drain System - a Pilot Study received a DIOV drainage system following Microbiological data included pre- an orthopedic oncologic or infectious DIOV culture results (for Group 2 only) and debridement procedure. Patients were post-DIOV culture results for both groups at stratified into two groups based on their time removal. Specimen fluid was obtained procedure at time of DIOV placement: from the deep portions of hemovac tubing primary oncologic patients were placed in at time of removal via flush injection of 3cc Group 1, while infection debridement of sterile saline. Care was taken to ensure patients were placed in Group 2. While sterile techniques were used while Group 2 patients were known to have some specimens were gathered to minimize form of initial infection, all underwent serial iatrogenic contamination. Aerobic, debridements, and data gathered was from anaerobic, mycobacterial, and fungal agars the DIOVs placed at time of final were used in the microbiologic analyses. debridement. This presumes aseptic DIOV Microbiologic analyses were performed at a placement even in Group 2,as final single institution (University of Colorado debridement was determined after Hospital - Anschutz Medical Campus) with consecutive cultures were pan-negative, all cultures being held for at least 14 days. wounds were free of necrotic/ nonviable/ Regarding antibiotic use, all patients purulent material, and inflammatory in Group 1 received pre-incisional markers (i.e. c-reactive protein, white blood antibiotics per the standard orthopaedic cell count) were normalized or near normal. guidelines (typically a 1st generation The determination of final debridement was cephalosporin or lincomycin/ amino made by a single-surgeon (BL) in all cases. glycoside administered within 1 hour of Data Collected incision). Group 2 patients expectedly received a variety of antibiotic therapies. Demographic data obtained Details on antibiotic therapy were not included patient age, gender, and body mass included, as all therapies were felt to be index (BMI). Clinical data obtained similarly effective given the empiric-to- included diagnosis, procedure performed, narrow therapeutic model used at the host estimated blood