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Fakultät Für Chemie Und Pharmazie Fakultät für Chemie und Pharmazie ForschungsberichtForschungsbericht 2008-20102008-2010 BandBand 1010 Forschungsbericht der Fakultät für Chemie und Pharmazie für die Jahre 2008–2009 Band 10 Ludwig-Maximilians-Universität München II Herausgeber: Fakultät für Chemie und Pharmazie der Ludwig-Maximilians-Universität München München, 2010 Für den Inhalt der Beiträge sind die Autoren verantwortlich Sekretariat: Gertrud Adelmann Dekanat der Fakultät für Chemie und Pharmazie der Ludwig-Maximilians-Universität München Butanandtstr. 5–13 (Haus F), 81377 München Druck und Binden: UNI-Druck, Herbert Novotny, München Introduction by the Dean Einleitung des Dekans Our faculty is looking back to two very Die Jahre 2008 - 2009 waren für unsere successful years. Among the factors under- Fakultät sehr erfolgreich. Von besonderer lying the positive scientific development of Bedeutung für die positive For- our faculty, the impact arising from the schungsentwicklung waren die Impulse, die German Initiative of Excellence has been von der erfolgreichen Positionierung inner- most influential. The Cluster of Excellence halb der Exzellenzinitiative ausgingen. Der CIPS-M has very dynamically evolved into Exzellencluster CIPS-M hat sich hervor- a true scientific ―brand‖ that profoundly ragend entwickelt und ist zu einer echten increases the scientific visibility of our „Marke― geworden, welche die wissen- faculty on an international level. The high schaftliche Sichtbarkeit unserer Fakultät attractiveness of projects funded within the auf internationaler Ebene enorm fördert. initiative of excellence, in particular the Nicht zuletzt der hohen Attraktivität der im interdisciplinary cooperations, has been of Rahmen der Exzellenzinitiative geförderten great importance to recruit outstanding Projekte, insbesondere auch der in- researchers within the last two years. The terdisziplinären Kooperationen, ist es zu- establishment of an ―Alexander-von- zuschreiben, dass es in den letzten beiden Humboldt‖ professorship is a remarkable Jahren gelungen ist, herausragende For- example illustrating the successful recruit- scher/Innen für unsere Fakultät zu gewin- ment strategy of our faculty. The level of nen. Die Einwerbung einer Alexander-von- extramural funding has increased over the Humboldt-Professur ist ein besonders last two years. This favorable trend is seen augenfälliges Beispiel für die erfolgreiche for national funds, including the DFG- Berufungspolitik an unserer Fakultät. Die funded Collaborative Research Centers Drittmittelquote unserer Fakultät hat sich 646 and 749, as well as for european sehr positiv entwickelt. Dies gilt sowohl für projects. Members of our faculty succeeded DFG geförderten Verbünde, wie die beiden in raising highly prestigious funds from the SFBs 646 und 749, als auch für europäische European Research Council (ERC) and Projekte. Mitglieder unserer Fakultät waren were awarded internationally recognized erfolgreich bei der Einwerbung der prizes. In 2009, the Gene Center celebrated hochkompetitiven Forschungsgelder des its 25th anniversary and looked back to European Research Council (ERC) und more than two decades of top level re- erhielten wichtige Forschungspreise. Im search. With its new focus on Bio-Systems Jahre 2009 konnte der Lehrbereich Bio- research the Gene Center is well-prepared chemie zusammen mit dem Genzentrum for the challenges of the upcoming years. I München auf 25 Jahre internationale Spit- appreciate very much the decision of the zenforschung zurückblicken. Die Bioche- Bavarian and German Governments to sup- mie ist mit ihrem neuen Schwerpunkt der port Bio-Systems research by funding a Biosystem-Forschung bestens für die Zu- new research building on our campus. Drug kunft gerüstet. Es ist sehr erfreulich, dass research has also positively developed and die Bayerische Staatsregierung zusammen will gain additional momentum by the es- mit dem Bund den Ausbau der Systemfor- tablishment of the Center for System-based schung mit einem Forschungsneubau auf Drug Research. unserem Campus unterstützt. Auch das The abovementioned successes have been Gebiet der Pharmaforschung konnte sich in only made possible because of the enthu- den letzten beiden Jahren sehr positiv siasm of the members of our faculty and of weiterentwickeln und wird durch die our students. I would like to take the oppor- Einrichtung des Centers for System-based tunity to thank you for your strong com- Drug Research noch stärkeres Gewicht mitment to our faculty and wish you much erhalten. success for the next years ! Die erwähnten Erfolge waren nur durch das große Engagement und die Begeisterungs- fähigkeit der Mitarbeiter/Innen unserer Fakultät und unserer Studierenden möglich. Ihnen allen möchte ich an dieser Stelle sehr herzlich danken und für die nächsten Jahre viel Erfolg wünschen. Professor Dr. Martin Biel Dean Professor Dr. Martin Biel Dekan IV Zur Fakultät für Chemie und Pharmazie gehören das Department Chemie und Biochemie und das Department Pharmazie. Die aktuellen Adessen lauten: Department Chemie und Biochemie Butenandtstraße 5–13 (Haus D–F), 81377 München, Tel. 089/2180-0 Lehrbereich Anorganische Chemie: Haus D Lehrbereich Organische Chemie: Haus F Lehrbereich Physikalische Chemie: Haus E Butenandtstr. 5-13 81377 München Lehrbereich Biochemie/Genzentrum Feodor-Lynen-Straße 25, Haus A 81377 München, Tel. 089/2180-0 Department Pharmazie – Zentrum für Pharmaforschung – Butenandtstr. 5–13 (Haus B und C, teilweise Haus D), 81377 München, Tel. 089/2180-0 Lehrbereich Pharmazeutische Chemie: Haus C Lehrbereich Pharmazeutische Biologie: Haus B und Haus D Lehrbereich Pharmazeutische Technologie und Biopharmazie: Haus B Lehrbereich Pharmakologie für Naturwissenschaften: Haus C V Department Chemie Lehrbereich Anorganische Chemie Seiten Beck, Wolfgang 1– 3 Boehm, Hanns-Peter 4 Böttcher Hans-Christian 5 Johrendt, Dirk 6– 10 Karaghiosoff, Konstantin 11– 13 Klapötke, Thomas 14– 28 Klüfers, Peter 29– 33 Kornath, Andreas 34– 35 Lorenz, Ingo-Peter 36– 39 Lotsch, Bettina 40– 42 Müller-Buschbaum, Klaus 43– 46 Nöth, Heinrich 47– 50 Oeckler, Oliver 51– 54 Schmedt auf der Günne, Jörn 55– 57 Schnick, Wolfgang 58– 64 Sünkel, Karlheinz 65 Weber, Birgit 66– 68 Lehrbereich Biochemie Beckmann, Roland 69– 71 Conti, Elena 72– 73 Cramer, Patrick 74– 80 Fässler, Reinhold 81– 85 Förstemann, Klaus 86– 87 Gaul, Ulrike 88– 90 Grininger, Martin 91– 92 Hartl, F. Ulrich 93– 98 Hopfner, Karl-Peter 99–101 Mann, Matthias 102–111 Martin, Dietmar 112 Niessing, Dierk 113–114 Schäffner, Anton 115–116 Söding, Johannes 117–118 Sträßer, Katja 119–121 Tresch, Achim 122–124 Turck, Christoph 125–128 Wendler, Petra 129–130 Wolf, Eva 131–133 VI Lehrbereich Organische Chemie Carell, Thomas 134–140 Heuschmann, Manfred 141 Huisgen, Rolf 142 Knochel, Paul 143–150 Koszinowski, Konrad 151–152 Langhals, Heinz 153–157 Mayr, Herbert 158–163 Pfaendler, Hans Rudolf 164 Siebert, Stephan 165–167 Steglich, Wolfgang 168–169 Trauner, Dirk 170–175 Zipse, Hendrik 176–178 Lehrbereich Physikalische Chemie Bein, Thomas 179–185 Bräuchle, Christoph 186–193 Ebert, Hubertus 194–200 Günther, Sebastian 201–203 Hartschuh, Achim 204–207 Knözinger, Helmut 208–209 Ködderitzsch, Diemo 210–211 Lamb, Don C. 212–216 Michaelis, Jens 217–220 Scheu, Christina 221–223 de Vivie-Riedle, Regina 224–247 Wintterlin, Joost 228–230 Institut für Pharmazie – Zentrum für Pharmaforschung Lehrbereich Pharmazeutische Chemie Bracher, Franz 231–234 Krauss, Jürgen 235–237 Reimann, Eberhard 238 Stachel, Hans-Dietrich 239 Wanner, Klaus Theodor 240–242 VII Lehrbereich Pharmazeutische Biologie Fürst, Robert 243–244 Ogris, Manfred 245–249 Vollmar, Angelika 250–255 Wagner, Ernst 256–262 Wagner, Hildebert 263–264 Zahler, Stefan 265–266 Lehrbereich Pharmazeutische Technologie und Biopharmazie Coester, Conrad 267–269 Frieß, Wolfgang 270–273 Winter, Gerhard 274–280 Lehrbereich Pharmakologie für Naturwissenschaften Biel, Martin 281–284 Michalakis, Stylianos 285–287 Wahl-Schott, Christian 288–289 Index Fachgebiete/Autoren 290–303 Alphabetisches Namensverzeichnis 304–305 1 Lehrbereich Anorganische Chemie Univ.-Prof. Dr. rer. nat. Wolfgang Beck, em. Geboren 1932 in München, Chemiestudium Technische Hochschule München, Promo- tion bei Prof. W. Hieber (1960) und Habilitation (1963) an der TH München, seit 1968 o. Professor und Vorstand des Instituts für Anorganische Chemie, 1973/74 Dekan der Fakultät für Chemie und Pharmazie, 1977 Gastprofessor an der University of Wiscon- sin, Madison, 1990/92 Mitglied des Senats und der Versammlung, Fachgutachter der Deutschen Forschungsgemeinschaft (1981- 1992); seit 2000 Emeritus. Mitgliedschaften GDCh, American Chemical Society, The Royal Society of Chemistry Förderung Fonds der Chemischen Industrie Forschungsprojekte Metallorganische und Komplex-Chemie: Metallkomplexe mit biologisch wichtigen Li- ganden (vor allem -Aminosäuren, Peptide), metallvermittelte Synthese von Peptiden und Cyclopeptiden. Nitrosyl-Metallkomplexe. Publikationen 1 Mercury fulminate: ONC-Hg-CNO or CNO-Hg-ONC - a DFT study Wolfgang Beck, Thomas M. Klapötke THEOCHEM 848 (2008) 94-97. 2 Chirale Halbsandwich-Pentamethylcyclopentadienyl-Rhodium(III)- und Iri- dium(III)-Komplexe mit Schiff-Basen aus Salicylaldehyd und a- Aminosäureestern Andreas Böhm, Henri Brunner und Wolfgang Beck Z. Anorg. Allg. Chem. 2008, 634, 274-278. 3 Metal Complexes of Biologically Important Ligands, CLXIX Palladium(II) and Platinum(II) N,O-Chelate Complexes (R3P)(Cl)M( -aminoacidate) with the Anions of Serine, Threonine, 3,4-Dehydroproline and 4-Hydroxyproline Elfriede Schuhmann,
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