Vacuum Conveyors and Bulk Material Handling Solutions
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PI3K Inhibitors in Cancer: Clinical Implications and Adverse Effects
International Journal of Molecular Sciences Review PI3K Inhibitors in Cancer: Clinical Implications and Adverse Effects Rosalin Mishra , Hima Patel, Samar Alanazi , Mary Kate Kilroy and Joan T. Garrett * Department of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267-0514, USA; [email protected] (R.M.); [email protected] (H.P.); [email protected] (S.A.); [email protected] (M.K.K.) * Correspondence: [email protected]; Tel.: +1-513-558-0741; Fax: +1-513-558-4372 Abstract: The phospatidylinositol-3 kinase (PI3K) pathway is a crucial intracellular signaling pathway which is mutated or amplified in a wide variety of cancers including breast, gastric, ovarian, colorectal, prostate, glioblastoma and endometrial cancers. PI3K signaling plays an important role in cancer cell survival, angiogenesis and metastasis, making it a promising therapeutic target. There are several ongoing and completed clinical trials involving PI3K inhibitors (pan, isoform-specific and dual PI3K/mTOR) with the goal to find efficient PI3K inhibitors that could overcome resistance to current therapies. This review focuses on the current landscape of various PI3K inhibitors either as monotherapy or in combination therapies and the treatment outcomes involved in various phases of clinical trials in different cancer types. There is a discussion of the drug-related toxicities, challenges associated with these PI3K inhibitors and the adverse events leading to treatment failure. In addition, novel PI3K drugs that have potential to be translated in the clinic are highlighted. Keywords: cancer; PIK3CA; resistance; PI3K inhibitors Citation: Mishra, R.; Patel, H.; Alanazi, S.; Kilroy, M.K.; Garrett, J.T. -
Screw Conveyor Engineering Guide Design Engineering Manufacturing
Screw Conveyor Engineering Guide Design Engineering Manufacturing SCREW CONVEYOR BASICS The KWS Screw Conveyor Engineering Guide will provide assistance in the design of a screw conveyor or system, yielding optimum performance and efficiency . Primary considerations for the selection of a screw conveyor are: 1 . Type and condition of the bulk material to be conveyed including maximum particle size and specific bulk density 2 . Capacity or feed rate of bulk material to be conveyed expressed in pounds per hour, tons per hour, or cubic feet per hour 3 . Required distance and incline the bulk material is to be conveyed 4 . Design conditions such as materials of construction, inlet feed conditions and operating temperature The Engineering Guide provides the necessary information for selecting a screw conveyor in a series of five steps . These steps are arranged in logical order and are divided into separate sections for simplicity . The five steps are: 1 . Establish characteristics of the bulk material to be conveyed . 2 . Determine conveyor size and speed based on capacity . 3 . Calculate horsepower requirements . 4 . erifyV torque rating of components . 5 . Select conveyor components . Typical KWS Screw Conveyor 1 Screw Conveyor Engineering Guide Design Engineering Manufacturing TYPES OF SCREW CONVEYORS Horizontal Screw Conveyors Horizontal screw conveyors are the most widely used type of screw conveyor . Used to convey bulk materials from one part of a process to another, horizontal screw conveyors are available in a wide range of sizes, lengths, configurations and materials of construction . Screw conveyors are typically designed to convey bulk materials at 15, 30 or 45-percent trough loading, depending upon material characteristics of the specific bulk material . -
A Report to the President U.S
A Report to the President U.S. Department of the Interior 2017-2021 REPORT TO THE PRESIDENT 2017-2021 U.S. Department of the Interior JANUARY 15, 2021 Report to the President Report to the President U.S. DEPARTMENT OF THE INTERIOR LETTER TO THE PRESIDENT The Department of the Interior (Department) has focused on improving the ways we serve the American public, while moving forward with your policy priorities. In doing so, the Department has made incredible progress furthering conservation stewardship, expanding opportunities to hunt and fish on public lands, improving core administrative functions, creating a common-sense regulatory regime, and enhancing our Nation’s energy independence. On behalf of the more than 65,000 Secretary David L. Bernhardt dedicated employees who work diligently across our Nation to accomplish important missions in service to the American people, I am pleased to present the Department’s Summary of Actions Report for 2017- 2021. This report highlights the Department’s major and historic achievements toward fulfilling your vision on behalf of all Americans. David L. Bernhardt Secretary of the Interior Page 1 Report to the President PURPOSE AND INTRODUCTION Secretary Bernhardt and First Lady Melania Trump at Grand Teton National Park From the beginning days of the Trump-Pence Administration, President Donald J. Trump gave clear direction to the Department of the Interior (Department, DOI, or Interior). He set priorities and ambitious goals, challenging Federal agencies through Governmentwide Executive orders, Presidential memoranda, and other actions to deliver better results for the American people. Interior has worked relentlessly to implement the President’s agenda for the betterment of our society and economy. -
Bulk Powder Solid Handling System
pneuCONVEYOR systems & engineers Tubular Chain Drag Conveyor, Pneumatic Powder Conveying system (Dense / Dilute phase), Vacuum Powder Loader, Screw Conveyor, Big bag unloading & Weighing Batching systems. Experience in motion ! a technology that allows you to convey your powder safely and easily. PAGE 1 Bulk Material & Powder Handling Systems Industries Materials Chemicals / Plastics / (examples) Cement Construction / Food / Hydrated Lime Fly Ash Minerals /Environmental Salt Sugar Micro Silica Charcoal Characteristics : Chalk capacity 2t/h–35t/h, Sludge as well as special design. Milk Powder designed for concrete production applications. pneumatic conveying into working or storage silos. pneuCONVEYOR systems - plant design and engineering – high end solutions Basic aspects of all pneuCONVEYOR solutions: environmental friendliness, sustainability and economic concepts. Content – Plant Engineering. Components – partial systems – complete systems Knowledge and knowhow – expertise – experience in theory and practice design – process engineering – process technology – turnkey objects The pneuCONVEYOR service package: assembly, commissioning, service, maintenance and staff training What is Bulk Material & Powder Handling system? Bulk material handling system is used to transport, process, and package bulk materials, like powder bulk solids. There are many different types of bulk material handling systems which are distinguished by the types of applications for which they are used and the kinds of materials they are constructed to handle. _________________HourDESIGN, DEVELOPMENT & FABRICATION _________________Day OF PNEUMATIC CONVEYING SYSTEMS HourspneuCONVEYOR per Day pneumatic conveying Days per systems Week are used for the transportation of bulk materials and granulates in pipelines. The transportation of solids via overpressure and under pressure is an indispensable technology in the field of powder material handling in order to convey bulk material from point A to point B. -
R. Todd Swinderman, P.E., and Andy Marti, Martin Engineering, US, Discuss How Bulk Material Science Is Improving Power Plant
ne of the greatest advancements in the engineering of R. Todd Swinderman, P.E., coal handling systems is the increased use of bulk material science. This field is focused on the testing and and Andy Marti, analysis of both the bulk solid and the construction Omaterials that the bulk solids will move on, over or through. Bulk Martin Engineering, US, material science is an interdisciplinary field, centred on determining the physical properties of bulk materials and applying those discuss how bulk material properties to various problems in the design of bulk material handling systems and components. science is improving Combined with computer-based engineering and modelling systems, bulk materials science offers several potential improvements power plant coal for coal handling operations in power plants. These include helping to manage flow, reduce bottlenecks, minimise dust, spillage and handling. carryback, extend equipment life and reduce maintenance expenses – all improving a plant’s availability, efficiency and profitability. Since the first conveyor was designed, the basic properties of bulk materials, such as bulk density and angle of repose, have been used to size the system and calculate its power requirements. Modern bulk January 2012 | World Coal | 51 material science traces its roots to Improved testing and computerised horizontal. The surcharge angle is work at the University of Utah, which engineering now make it possible to useful in conveyor design for determined the critical dimensions of improve designs of specific systems to determining the profile of the load on mass-flow bins, based on the strength perform as expected with identified the belt for various belt widths and of the bulk material under various materials. -
Monique Jannette Artist, Paralympian, and Former Civil Rights Lawyer
Texas Disability History Collection, University of Texas at Arlington Monique Jannette Artist, Paralympian, and former Civil Rights Lawyer Interview conducted by Mark Harris In 2016 in Dallas, Texas Disability Studies Minor Special Collections and Archives University of Texas at Arlington Copyright © 2016 by University of Texas at Arlington Libraries Biography Monique Jannette was born September 23, 1962 and graduated from Warren Travis White High School in Dallas, Texas, earned a Bachelor’s of Arts degree in Geology from the University of Texas at Arlington in 1987, and her Law Degree from Southern Methodist University in 1992. While in middle school and high school, she became interested in science and competitive diving. Jannette exceled at diving and traveled throughout the United States and other countries with diving teams. She earned a full scholarship to Southern Methodist University (SMU), but due to an accident shortly after graduation from high school in 1980, she became paraplegic. Starting in 1981, Jannette attended the University of Texas at Arlington (UTA), where she studied geology and participated in adaptive track and field under the direction of Jim Hayes. While attending UTA, she was selected to the 1988 U.S. Paralympic Track and Field team, and Table Tennis team in Seoul, South Korea. In 1992 she was selected again to compete with the U.S. Paralympic Team in Barcelona, Spain. Upon graduating from UTA, Jannette went back to SMU to study law. During her time there she collaborated with architects to make SMU more accessible to people with disabilities. After graduating law school, she and a partner began to practice civil rights law, helping the communities and business in and around the Dallas area. -
Handling | Bedeschi 1
HANDLING | BEDESCHI 1 HANDLING Since 1908 PROVIDING RELIABLE AND INNOVATIVE SOLUTIONS FOR OUR CUSTOMERS “ IS OUR MISSION SINCE 1908 “ HANDLING PROFILE | BEDESCHI 4 SINCE 1908 | BEDESCHI Accruing know-how and expertise since 1908 Bedeschi was established in 1908 and is today one of the oldest European companies in its industry. At the beginning of the XX century the founder, Guglielmo Bedeschi, designed and built a new “extruder” awarded with the Certificate of Honor and the First Degree Gold Metal, during the international Expo in Turin 1909. Since then the Company has grown and extended its fields of application without losing the advantages and flexibility of a family company. Today the fourth generation is running the Company even if the Group dimension is now comparable to the biggest players in the industries. Bedeschi diversified Business Units can provide Customers with complete turn-key solutions for: • Bulk Handling, Marine and Mining • Container Logistics • Bricks HANDLING | BEDESCHI 5 More than a century of Bedeschi Diversification is the Group major asset to nourish its continuous innovation attitude in products and service to tailor fit Customer’s needs. TAKING THE BEST FROM THE PAST TO BUILD THE FUTURE. 6 SINCE 1908 | BEDESCHI Our Values We strongly believe that our success relies on PEOPLE. FAST DECISION The long lasting relationships with our Customers MAKING and our teammates are able to keep us growing every day. GREEN & SAFE RESPONSIBILITY Reliability TRAINING AFTER SALES SINCE IN HOUSE PRIDE People 110 YEARS MANUFACTURING COMMITMENT STAKEHOLDERS Know How TAILOR LEAN MADE MANUFACTURING DIVERSIFICATION HANDLING | BEDESCHI 7 We care about future A company must be one of the most important actors of social development and environmental protection. -
Chapter 14 Yards and Terminals1
CHAPTER 14 YARDS AND TERMINALS1 FOREWORD This chapter deals with the engineering and economic problems of location, design, construction and operation of yards and terminals used in railway service. Such problems are substantially the same whether railway's ownership and use is to be individual or joint. The location and arrangement of the yard or terminal as a whole should permit the most convenient and economical access to it of the tributary lines of railway, and the location, design and capacity of the several facilities or components within said yard or terminal should be such as to handle the tributary traffic expeditiously and economically and to serve the public and customer conveniently. In the design of new yards and terminals, the retention of existing railway routes and facilities may seem desirable from the standpoint of initial expenditure or first cost, but may prove to be extravagant from the standpoint of operating costs and efficiency. A true economic balance should be achieved, keeping in mind possible future trends and changes in traffic criteria, as to volume, intensity, direction and character. Although this chapter contemplates the establishment of entirely new facilities, the recommendations therein will apply equally in the rearrangement, modernization, enlargement or consolidation of existing yards and terminals and related facilities. Part 1, Generalities through Part 4, Specialized Freight Terminals include specific and detailed recommendations relative to the handling of freight, regardless of the type of commodity or merchandise, at the originating, intermediate and destination points. Part 5, Locomotive Facilities and Part 6, Passenger Facilities relate to locomotive and passenger facilities, respectively. -
TIVAR® 88 Lining Solutions in the Bulk Material Handling Industry, Linings, Due to the Material’S Low Coefficient of Friction
TIVAR® 88 High Performance Lining Solutions Engineering Case Book Applications, Case Studies, & Technical Resources to assist your design process Introduction to Quadrant’s SystemTIVAR® Engineering Group TIVAR® 88 HIGH PERFORMANCE LINING SOLUTIONS For more than 30 years, Quadrant’s SystemTIVAR® Arching, ratholing, erratic material flow and aggressive Engineering Group has been recognized for consistent, flow promotion devices (vibrators, sledge hammers, etc.) reliable products, highly qualified staff and innovative can be reduced or even eliminated with TIVAR® 88 lining solutions in the bulk material handling industry, linings, due to the material’s low coefficient of friction. earning a reputation throughout the world for providing TIVAR® 88 linings are also recognized worldwide for long-term, cost-effective lining solutions. Well-known by their abrasion-, corrosion-, moisture- and chemical- many of the world’s engineering experts and consultants resistant properties that contribute to a long wear-life, in the bulk material handling field, Quadrant’s lower maintenance costs and reduced downtime. SystemTIVAR® Engineering Group has assumed a Quadrant’s SystemTIVAR® Engineering Group team will leadership role in the industry by developing and design, fabricate and install TIVAR® 88 linings anywhere introducing lining products to meet individual customer in the world. needs and expectations. Quadrant is the world’s largest processor of semi-finished UHMW-PE, sold under the TIVAR® and QuickSilver® brand names. Headquartered in Reading, PA, USA, with manufacturing, fabricating and sales facilities worldwide, Quadrant began processing TIVAR® products in 1970 and started developing and manufacturing plastic materials over 60 years ago. Quadrant’s SystemTIVAR® Engineering Group offers the bulk material handling industry a solutions-oriented approach that includes full-line processing methods for TIVAR® products, specially formulated grades of TIVAR®and engineering and technical support services. -
Bulk Material Handling Components RELIABILITY IS ESSENTIAL 100% Quality for Your Success
RELIABILITY IS ESSENTIAL 100% quality for your success Bulk material handling components www.zeppelin-systems.com ENGINEERING YOUR SUCCESS Every Zeppelin plant is developed according to the clients’ specific requirements, and realized, thanks to our customized innovative processes and technologies. The knowledge we have acquired over more than 60 years of plant manufacturing and the world’s largest network for bulk material handling is the key to providing ideal solutions, whatever the challenge; after all, your success is our goal. Zeppelin plant engineering – business fields Polyolefin Plants Plants for plastics producers and forwarders Plastics & Rubber Plants Plants for the plastics processors and rubber industry Food Processing Plants Plants for the food, confectionery and baking industry Mixing Technology HENSCHEL-Mixers®, mixing systems Silos Storage silos, mixing silos, process silos Components Rotary feeders, diverter valves, discharge and dosing units, sifters, filters … Service Spare parts, customer service and consulting Modernization / Revamping Optimization of production lines and plant controls Zeppelin Systems, the world leading plant manufacturer for high quality bulk Quality Service material handling, has remarkably grown over the past 60 years. We cover Measurement, testing and welding technology, non-destructive testing, the demands of a wide range of industries and supply all plant manufacturing calibration services, QM consulting services and training services from one single source, whether basic engineering, in-house -
To Consignors Hip Color & No
Index to Consignors Hip Color & No. Sex Name,Year Foaled Sire Dam Barn 7 Consigned by Ashview Farm LLC (Mr. and Mrs. Wayne G. Lyster III), Agent Broodmare 1780 b. m. Hurricane Victress, 1997 Sharp Victor Woody's Miss Broodmare prospect 1840 dk. b./br. m. Military Victress, 2002 Military Hurricane Victress Barn 9 Consigned by Blandford Stud (Padraig Campion), Agent Broodmare 1693 ch. m. Dance Trick, 1995 Diesis (GB) Performing Arts (IRE) Racing or broodmare prospect 1846 b. m. Missisipi Star (IRE), 2003 Mujahid Kicka Racing or stallion prospect 1874 b. c. Wafi City, 2004 E Dubai My Jody Racing prospect 1611 dk. b./br. f. unnamed, 2006 Roaring Fever Waywayanda Barn 2 Consigned by Bluewater Sales LLC, Agent I Yearling 1631 b. f. unnamed, 2007 Chapel Royal Alma Mater Barn 2 Consigned by Bluewater Sales LLC, Agent III Broodmare 1850 ch. m. Miss Phone Chatter, 2000 Phone Trick Passing My Way Broodmare prospect 1732 ch. m. Fancy Forever, 2003 Wild Rush Opinionated Lady Barn 2 Consigned by Bluewater Sales LLC, Agent IV Broodmare prospect 1678 dk. b./br. f. Classy Clarita, 2004 Mr. Greeley Link to Erin Barn 2 Consigned by Bluewater Sales LLC, Agent V Yearlings 1589 dk. b./br. c. unnamed, 2007 Offlee Wild Theatriken 1610 b. c. unnamed, 2007 Maria's Mon Way Beyond Barn 2 Consigned by Bluewater Sales LLC, Agent VI Racing or broodmare prospect 1694 gr/ro. f. Dancing Cherokee, 2004 Yonaguska Dancapade Barn 2 Consigned by Bluewater Sales LLC, Agent VII Yearling 1787 dk. b./br. f. unnamed, 2007 Offlee Wild Jettin Diplomacy Barn 2 Consigned by Bluewater Sales LLC, Agent VIII Broodmare 1754 b. -
Faculdade De Medicina Veterinária
UNIVERSIDADE DE LISBOA Faculdade de Medicina Veterinária PERFORMANCE EVALUATION IN IRISH RACEHORSES WITH DORSAL DISPLACEMENT OF THE SOFT PALATE FOLLOWING THE LARYNGEAL TIE-FORWARD PROCEDURE RICARDO MAÇARICO BAIÃO CONSTITUIÇÃO DO JÚRI ORIENTADOR Doutora Paula Alexandra Botelho Garcia de Doutor José Paulo Pacheco Sales Luís Andrade Pimenta Tilley CO-ORIENTADOR Doutor José Paulo Pacheco Sales Luís Dr. Turlough Mc Nally Doutora Maria Rita Martins Garcia da Fonseca 2015 LISBOA UNIVERSIDADE DE LISBOA Faculdade de Medicina Veterinária PERFORMANCE EVALUATION IN IRISH RACEHORSES WITH DORSAL DISPLACEMENT OF THE SOFT PALATE FOLLOWING THE LARYNGEAL TIE-FORWARD PROCEDURE RICARDO MAÇARICO BAIÃO DISSERTAÇÃO DE MESTRADO INTEGRADO EM MEDICINA VETERINÁRIA CONSTITUIÇÃO DO JÚRI ORIENTADOR Doutora Paula Alexandra Botelho Garcia de Doutor José Paulo Pacheco Sales Luís Andrade Pimenta Tilley CO-ORIENTADOR Doutor José Paulo Pacheco Sales Luís Dr. Turlough Mc Nally Doutora Maria Rita Martins Garcia da Fonseca 2015 LISBOA I dedicate this work to my father who hasn’t had the chance to see me finish it. i ii Acknowledgments This is the final step from a journey that I choose to be my life. During this journey, many people positively interfered, so here is my acknowledgment to all of them. Firstly, to my parents that always encouraged me to follow my dream and made everything possible for me to achieve it. I need to make a special reference to my father that made me the man I am today and always wanted me to be successful, so this is for you. Secondly, to Doctor Turlough Mc Nally, my co-supervisor, for accepting me at Anglesey Lodge Equine Hospital and for setting a great example of professionalism.