Table 2s

List of the probe sets (each of them corresponding to a or a gene family) resulting significantly modulated (see Table 1s) in DPTs following 3 hour Dex and whose increased/decreased modulation was above a chosen cut-off (for log increase > 0.75 and for log decrease < -0.5). In the Affymetrix platform each probe set is represented by an ID number (column 1) linked to a gene or gene family (columns 2 and 3). The modulation of the expression in the treated DPTs is reported as log in 2 basis (a 2 fold increase expression is reported as 1 and a 2 fold decrease expression is reported as –1). To allow comparison, the ID numbers of several data banks corresponding to the probe set ID are reported in columns 6- 14 and 19. numbers and the pathway(s) in which the gene is involved are reported in columns 15-18.

Affymetrix GeneChip Array Murine Genome U74Av2 Array Genome March 2005 (NCBI 34) Version column 1 column 2 column 3 column 4 column 5 column 6 column 7 column 8 column 9 column 10 column 11 column 12 column 13 column 14

Transcript Log2 Fold Representative RefSeq Transcript Probe Set ID Gene Title Gene Symbol ID (Array UniGene ID Ensembl SwissProt EC RefSeq ID MGI Name Modulation Public ID Gene ID Design)

ENSMUSG0 Q9CXH2 /// 95151_at RIKEN cDNA 2810052M02 gene 2810052M02Rik -2.8 5674136 AW061307 Mm.29475 67220 --- NP_075809.1 NM_023320 --- 0000015745 Q9JIY0

ENSMUSG0 P41133 /// 92614_at inhibitor of DNA binding 3 Id3 -2 5663577 M60523 Mm.110 15903 --- NP_032347.1 NM_008321 --- 0000007872 Q545W1

5690864_R ENSMUSG0 160829_at pleckstrin homology-like domain, family A, member 1 Phlda1 -1.7 U44088 Mm.3117 21664 Q62392 --- NP_033370.1 NM_009344 --- C 0000020205 Q61263 /// 5709592_R Q8C795 /// 95887_at sterol O-acyltransferase 1 Soat1 -1.4 AI451008 Mm.28099 --- 20652 --- NP_033256.1 NM_009230 104665 C Q8R3K7 /// Q5XK32

ENSMUSG0 101410_at claudin 4 Cldn4 -1.1 5695544 AB000713 Mm.7339 12740 O35054 --- NP_034033.1 NM_009903 --- 0000047501

ENSMUSG0 O54825 /// 160227_s_at bystin-like Bysl -1.1 5670962 AI132491 Mm.27291 53414 --- NP_058555.2 NM_016859 --- 0000023988 Q543N4

P35951 /// Q91ZJ1 /// 5691030_R ENSMUSG0 160832_at low density lipoprotein receptor Ldlr -1.1 Z19521 Mm.3213 16835 Q8VCT0 /// --- NP_034830.1 NM_010700 96765 C 0000032193 Q6GTJ9 /// Q8CAV5

P00920 /// ENSMUSG0 Q9DCT3 /// 92642_at carbonic anhydrase 2 Car2 -1.1 5663753 M25944 Mm.1186 12349 EC:4.2.1.1 NP_033931.3 NM_009801 --- 0000027562 Q7TPE1 /// Q6LDQ7 ENSMUSG0 P11416 /// 92901_at retinoic acid receptor, alpha Rara -1.1 5705154 M60909 Mm.103336 19401 --- NP_033050.1 NM_009024 97856 0000037992 Q5BLJ8

Q60980 /// Q5K2K0 /// ENSMUSG0 100010_at Kruppel-like factor 3 (basic) Klf3 -1 5694203 U36340 Mm.319499 16599 Q8BV07 /// --- NP_032479.1 NM_008453 1342773 0000029178 Q545J5 /// Q8C7X1 92653_at RIKEN cDNA D530037H12 gene D530037H12Rik -1 5703870 AI482432 ------96893 ------2138683 Q60980 /// Q5K2K0 /// ENSMUSG0 100011_at Kruppel-like factor 3 (basic) Klf3 -0.9 5694204 AI851658 Mm.319499 16599 Q8BV07 /// --- NP_032479.1 NM_008453 --- 0000029178 Q545J5 /// Q8C7X1 ENSMUSG0 100902_at RIKEN cDNA 2610019F03 gene 2610019F03Rik -0.9 5695053 AI846549 Mm.5727 72148 Q8C5P7 --- NP_776105.1 NM_173744 --- 0000050052

5675893_R ENSMUSG0 Q9CRA4 /// 160388_at sterol-C4-methyl oxidase-like Sc4mol -0.9 AI848668 Mm.30119 66234 --- NP_079712.1 NM_025436 --- C 0000031604 Q543V8

5705151_R ENSMUSG0 92900_at RIKEN cDNA E230012J19 gene Rere -0.9 AU040769 Mm.291274 68703 Q80TZ9 --- XP_204015.2 XM_204015 --- C 0000039852 Q8C9N5 /// ENSMUSG0 Q9CYC2 /// 93614_at Ras-related GTP binding D Rragd -0.9 5706340 AA600647 Mm.34108 52187 --- NP_081767.1 NM_027491 --- 0000028278 Q6GTT2 /// Q7TT45

ENSMUSG0 94197_at UDP-glucose ceramide glucosyltransferase Ugcg -0.9 5708696 D89866 Mm.198803 22234 O88693 --- NP_035803.1 NM_011673 1332243 0000028381

ENSMUSG0 94322_at squalene epoxidase Sqle -0.9 5668876 D42048 Mm.296169 20775 P52019 --- NP_033296.1 NM_009270 --- 0000022351

P34960 /// ENSMUSG0 95339_r_at matrix metalloproteinase 12 Mmp12 -0.9 5709167 M82831 Mm.2055 17381 Q6GX99 /// EC:3.4.24.65 NP_032631.1 NM_008605 97005 0000049723 Q8BJC0 ENSMUSG0 97977_at netrin 1 Ntn1 -0.9 5690862 AA645293 Mm.39095 18208 O09118 --- NP_032770.1 NM_008744 105088 0000020902

ENSMUSG0 98609_at septin 9 Sept9 -0.9 5678263 AJ250723 Mm.38450 53860 Q80UG5 --- NP_059076.1 NM_017380 1858222 0000059248

98756_at RIKEN cDNA 2810043O03 gene 2810043O03Rik -0.9 5715344 W91704 ------72697 ------1919947

5682019_R ENSMUSG0 160545_at cyclin D3 Ccnd3 -0.8 M86183 Mm.246520 12445 P30282 --- NP_031658.1 NM_007632 88315 C 0000034165

Q99JF5 /// 5688716_R ENSMUSG0 160770_at mevalonate (diphospho) decarboxylase Mvd -0.8 AW049778 Mm.28146 192156 Q8BTM4 /// --- NP_619597.1 NM_138656 --- C 0000006517 Q922D7

Q5FWI0 /// ENSMUSG0 161817_f_at RIKEN cDNA 4930422J18 gene 4930422J18Rik -0.8 5742721 AV376312 Mm.30 74646 Q8BJA4 /// --- NP_083311.1 NM_029035 --- 0000039911 Q9D5L7

ENSMUSG0 P13011 /// 95758_at stearoyl-Coenzyme A desaturase 2 Scd2 -0.8 5674769 M26270 Mm.193096 20250 --- NP_033154.1 NM_009128 --- 0000025203 Q8BH96

P37889 /// ENSMUSG0 100928_at 2 Fbln2 -0.7 5695133 X75285 Mm.249146 14115 Q8C2U8 /// --- NP_032018.1 NM_007992 95488 0000064080 Q99K58

O35219 /// potassium voltage-gated channel, subfamily H (eag- ENSMUSG0 Q53Z09 /// 100961_at Kcnh2 -0.7 5695237 AF012871 Mm.6539 16511 --- NP_038597.1 NM_013569 1341722 related), member 2 0000038319 Q80WG1 /// Q80XE8

P53986 /// Q8BPS5 /// solute carrier family 16 (monocarboxylic acid ENSMUSG0 101588_at Slc16a1 -0.7 5682940 AF058055 Mm.9086 20501 Q8C2E6 /// --- NP_033222.1 NM_009196 --- transporters), member 1 0000032902 Q8C571 /// Q544N9 102978_at RIKEN cDNA A430104N18 gene A430104N18Rik -0.7 5697376 AI021175 ------78591 ------1925841 104413_at ------0.7 5699922 AI834976 ------Q07916 /// 5689378_R ENSMUSG0 Q6X2R9 /// 160793_at POU domain, class 6, transcription factor 1 Pou6f1 -0.7 AI851313 Mm.28825 19009 --- NP_034257.1 NM_010127 102935 C 0000009739 Q5U4D4 /// Q6X2S0 Q5FWI0 /// ENSMUSG0 161013_f_at RIKEN cDNA 4930422J18 gene 4930422J18Rik -0.7 5700277 AI596360 Mm.30 74646 Q8BJA4 /// --- NP_083311.1 NM_029035 --- 0000039911 Q9D5L7 Q03347 /// Q8BQ09 /// 92399_at runt related transcription factor 1 Runx1 -0.7 5703164 D26532 Mm.4081 --- 12394 --- NP_033951.1 NM_009821 99852 Q8CAV1 /// Q6NSS1

ENSMUSG0 92832_at suppressor of cytokine signaling 1 Socs1 -0.7 5664163 U88325 Mm.130 12703 O35716 --- NP_034026.1 NM_009896 --- 0000038037

Q60790 /// ENSMUSG0 Q6PG24 /// 93319_at RAS p21 protein activator 3 Rasa3 -0.7 5665769 U20238 Mm.18517 19414 --- NP_033051.1 NM_009025 --- 0000031453 Q8C6G4 /// Q925V1

Q8BTY2 /// Solute carrier family 4, sodium bicarbonate 93471_at Slc4a7 -0.7 5706216 AI594427 Mm.258893 --- 218756 Q8BWZ4 /// --- XP_147798.3 XM_147798 --- cotransporter, member 7 Q9JL09 Mid1 interacting protein 1 (gastrulation specific G12- ENSMUSG0 95135_at Mid1ip1 -0.7 5674038 AI844396 Mm.29429 68041 Q9CQ20 --- NP_080800.1 NM_026524 --- like (zebrafish)) 0000008035 Q8BGW5 /// ENSMUSG0 Q8C154 /// 95655_at RIKEN cDNA 5830411E10 gene 5830411E10Rik -0.7 5674236 AA717740 Mm.196290 109019 --- NP_082972.1 NM_028696 1923258 0000026107 Q8C164 /// Q8R2P2

Q01705 /// ENSMUSG0 97497_at Notch gene homolog 1 (Drosophila) Notch1 -0.7 5676563 Z11886 Mm.290610 18128 Q8K428 /// --- NP_032740.2 NM_008714 --- 0000026923 Q8BY39 ENSMUSG0 Q9JMK2 /// 97925_at casein 1, epsilon Csnk1e -0.7 5690604 AB028241 Mm.30199 27373 --- NP_038795.3 NM_013767 --- 0000022433 Q9QUI3

5692333_R ENSMUSG0 O88455 /// 98989_at 7-dehydrocholesterol reductase Dhcr7 -0.7 AF057368 Mm.249342 13360 EC:1.3.1.21 NP_031882.1 NM_007856 --- C 0000058454 Q711T1

ENSMUSG0 Q920E5 /// 99098_at farnesyl diphosphate synthetase Fdps -0.7 5678479 AW045533 Mm.39472 110196 --- NP_608219.1 NM_134469 --- 0000059743 Q5M8R9

O89091 /// ENSMUSG0 99602_at Kruppel-like factor 10 Klf10 -0.7 5679360 AF064088 Mm.4292 21847 Q61596 /// --- NP_038720.1 NM_013692 --- 0000037465 Q8C900

Q9JMH6 /// Q99P49 /// 99985_at thioredoxin reductase 1 Txnrd1 -0.7 5694024 AB027565 Mm.210155 --- 50493 EC:1.8.1.9 NP_056577.2 NM_015762 1354175 Q8CI31 /// Q9CSV5

Q06831 /// Q8BPK5 /// 101430_at SRY-box containing gene 4 Sox4 -0.6 5695610 AW124153 Mm.240627 --- 20677 Q8BQ53 /// --- NP_033264.2 NM_009238 --- Q8CE56 /// Q5SW95

P97443 /// ENSMUSG0 101904_at SET and MYND domain containing 1 Smyd1 -0.6 5696145 U76372 Mm.234274 12180 Q8BMV4 /// --- NP_033892.1 NM_009762 104790 0000055027 Q6DFW7

Q61609 /// ENSMUSG0 Q8CBJ1 /// 103065_at solute carrier family 20, member 1 Slc20a1 -0.6 5684428 M73696 Mm.272675 20515 --- NP_056562.1 NM_015747 108392 0000027397 Q8CF68 /// Q91YQ9

ENSMUSG0 P70338 /// 103259_at growth factor independent 1 Gfi1 -0.6 5697591 U58972 Mm.2078 14581 --- NP_034408.1 NM_010278 103170 0000029275 Q8C287

P51576 /// ENSMUSG0 103971_at purinergic receptor P2X, ligand-gated ion channel, 1 P2rx1 -0.6 5698915 X84896 Mm.25722 18436 Q91WI3 /// --- NP_032797.2 NM_008771 1098235 0000020787 Q5SRU4 Q06831 /// Q8BPK5 /// 5665910_R 160109_at SRY-box containing gene 4 Sox4 -0.6 X70298 Mm.240627 --- 20677 Q8BQ53 /// --- NP_033264.2 NM_009238 98366 C Q8CE56 /// Q5SW95 Q61484 /// Q8BKS2 /// Q8BRB8 /// 5671601_R ENSMUSG0 NP_033773.1 /// NM_009643 /// 160255_at AHNAK nucleoprotein (desmoyokin) Ahnak -0.6 AA657044 Mm.203866 66395 Q8CEX7 /// ------C 0000059508 NP_780317.2 NM_175108 Q8CGE7 /// Q8R2L7 /// Q8VDN3 5674813_R ENSMUSG0 Q9D0U0 /// 160359_at RIKEN cDNA 1190002H23 gene 1190002H23Rik -0.6 AI854358 Mm.29811 66214 --- NP_079703.1 NM_025427 1913464 C 0000022018 Q9DBX1

farnesyl diphosphate synthetase /// similar to farnesyl Fdps /// 5677120_R ENSMUSG0 110196 /// Q920E5 /// NP_608219.1 /// NM_134469 /// 160424_f_at -0.6 AI846851 Mm.39472 ------pyrophosphate synthase LOC544723 C 0000059743 544723 Q5M8R9 XP_618801.1 XM_618801

5687998_R 160740_at gene model 561, (NCBI) Gm561 -0.6 AA615984 Mm.27391 --- 228715 ------XP_149199.2 XM_149199 --- C ENSMUSG0 Q4ZE88 /// 160824_at RIKEN cDNA B930013M22 gene B930013M22Rik -0.6 5690531 AI852741 Mm.37369 68750 --- NP_001013410.2 NM_001013392 --- 0000039087 Q66JZ8

5693108_R ENSMUSG0 160862_at protein tyrosine phosphatase 4a3 Ptp4a3 -0.6 AF035645 Mm.153891 19245 Q9D658 --- NP_033001.2 NM_008975 1277098 C 0000059895

Q571H1 /// 5698306_R ENSMUSG0 Q58DY7 /// 160965_at RAS p21 protein activator 4 Rasa4 -0.6 AA163960 Mm.290655 54153 --- XP_355650.2 XM_355650 1858600 C 0000004952 Q8BXL5 /// Q6PFQ7

P27546 /// Q60638 /// ENSMUSG0 Q7TPC6 /// 92795_at microtubule-associated protein 4 Mtap4 -0.6 5663949 M72414 Mm.217318 17758 --- NP_032659.1 NM_008633 --- 0000032479 Q7TPD4 /// Q80YQ5 /// Q8CFP5

ENSMUSG0 92830_s_at zinc finger protein 36 Zfp36 -0.6 5664143 X14678 Mm.333723 22695 P22893 --- NP_035886.1 NM_011756 99180 0000044786

ENSMUSG0 93593_f_at epithelial membrane protein 3 Emp3 -0.6 5666723 U87948 Mm.20829 13732 O35912 --- NP_034259.1 NM_010129 1098729 0000040212

P15037 /// ENSMUSG0 94246_at E26 avian leukemia oncogene 2, 3' domain Ets2 -0.6 5668473 J04103 Mm.290207 23872 Q8BMM2 /// --- NP_035939.2 NM_011809 95456 0000022895 Q99K36 Q8JZK9 /// ENSMUSG0 94325_at 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 Hmgcs1 -0.6 5668892 AW124932 Mm.61526 208715 Q8C5F4 /// EC:4.1.3.5 NP_666054.2 NM_145942 107592 0000052003 Q8K0I5

Q80YT2 /// ENSMUSG0 94401_s_at hemogen Hemgn -0.6 5687394 AA986548 Mm.25793 93966 Q8CF29 /// --- NP_444379.1 NM_053149 --- 0000028332 Q9ERZ0 Q64685 /// Q9JJM6 /// ENSMUSG0 94432_at beta galactoside alpha 2,6 sialyltransferase 1 St6gal1 -0.6 5687518 AI117157 Mm.149029 20440 Q8BM62 /// EC:2.4.99.1 NP_666045.1 NM_145933 --- 0000022885 Q8CA39 /// Q8K1L1 P01899 /// P01900 /// P14429 /// P01901 /// P01902 /// P04223 /// P01897 /// P14428 /// P03991 /// P01895 /// Q9D0T1 /// histocompatibility 2, D region 1 /// ENSMUSG0 110557 /// O19449 /// 95928 /// NP_001001892.1 NM_001001892 /// histocompatibility 2, K1, K region /// histocompatibility 2, 0000061232 14964 /// O19473 /// 95928 /// H2-D1 /// H2-K1 /// /// NP_034510.2 /// NM_010380 /// D region /// histocompatibility 2, Q region locus 1 /// /// 14972 /// Q31116 /// 95928 /// H2-L /// H2-Q1 /// NP_034520.1 /// NM_010390 /// histocompatibility 2, Q region locus 2 /// ENSMUSG0 14980 /// Q31193 /// 95928 /// H2-Q2 /// H2-Q7 NP_034522.1 /// NM_010392 /// histocompatibility 2, Q region locus 7 /// MHC 0000064174 15006 /// Q31198 /// 95928 /// /// LOC56628 /// NP_034524.2 /// NM_010394 /// 95773_at (A.CA/J(H-2K-f) class I antigen /// histocompatibility 2, -0.6 5731751 X16423 Mm.34421 /// 15013 /// Q9QWF4 /// --- 95928 /// H2-Q6 /// NP_064293.1 /// NM_019909 /// Q region locus 6 /// similar to MHC Q8/9d surface ENSMUSG0 15018 /// O19476 /// 95928 /// LOC386462 /// NP_997531.1 /// NM_207648 /// antigen /// similar to MHC class I histocompatibility 0000063968 386462 /// Q31168 /// 95928 /// LOC436493 /// XP_489790.1 /// XM_489790 /// antigen H-2 Q4 alpha chain precursor - mouse /// /// 436493 /// Q31191 /// 95928 /// LOC547343 XP_622837.1 /// XM_622837 /// similar to H-2 class I histocompatibility antigen, L-D ENSMUSG0 547343 /// Q6QMF3 /// 95928 /// XP_622842.1 XM_622842 alpha chain precursor 0000035929 56628 Q6RJ38 /// 95928 Q8SNA4 /// Q8R3Y0 /// Q9CZ20 /// Q06028 /// Q31154 /// Q31211 /// Q66JU6 /// Q7TN03 /// O19467 /// O78207 /// Q31156 ///

ENSMUSG0 P50543 /// 98600_at S100 calcium binding protein A11 (calizzarin) S100a11 -0.6 5678225 U41341 Mm.280038 20195 --- NP_058020.1 NM_016740 1338798 0000027907 Q545S1

O89091 /// ENSMUSG0 99603_g_at Kruppel-like factor 10 Klf10 -0.6 5679360 AF064088 Mm.4292 21847 Q61596 /// --- NP_038720.1 NM_013692 --- 0000037465 Q8C900 ENSMUSG0 Q8BWG8 /// NP_796205.1 /// NM_177231 /// 100473_at arrestin, beta 1 Arrb1 -0.5 5694847 AI851750 Mm.260193 109689 --- 99473 0000018909 Q8BTJ5 NP_835738.1 NM_178220

Q9QUR6 /// ENSMUSG0 100983_at prolyl endopeptidase Prep -0.5 5695305 AB022053 Mm.37294 19072 Q543B9 /// --- NP_035286.1 NM_011156 --- 0000019849 Q8C6A3

ENSMUSG0 101421_at ring finger protein 5 Rnf5 -0.5 5695575 AF030001 Mm.274542 54197 O35445 --- NP_062276.1 NM_019403 1860076 0000015478

P16382 /// ENSMUSG0 NP_001008700.1 NM_001008700 /// 102021_at interleukin 4 receptor, alpha Il4ra -0.5 5683450 M27960 Mm.233802 16190 Q921I3 /// ------0000030748 /// NP_034687.1 NM_010557 Q544A9

P27782 /// 5685093_R ENSMUSG0 Q8BGZ9 /// 103629_g_at lymphoid enhancer binding factor 1 Lef1 -0.5 D16503 Mm.255219 16842 --- NP_034833.2 NM_010703 96770 C 0000027985 Q8C402 /// Q8CAP4

103866_at ------0.5 5685406 AW124359 ------Q99PK2 /// Q8BRT9 /// neural precursor cell expressed, developmentally down- ENSMUSG0 Q8CFI0 /// 103906_f_at Nedd4l -0.5 5685527 AI840868 Mm.98668 83814 --- NP_114087.1 NM_031881 1933754 regulated gene 4-like 0000024589 Q641N8 /// Q80U03 /// Q8BS42

proline-serine-threonine phosphatase-interacting ENSMUSG0 103946_at Pstpip1 -0.5 5698786 U87814 Mm.2534 19200 P97814 --- NP_035323.1 NM_011193 1321396 protein 1 0000032322

ENSMUSG0 Q9Z1N7 /// 103970_at AT rich interactive domain 3B (Bright like) Arid3b -0.5 5698914 AF116847 Mm.350789 56380 --- NP_062663.1 NM_019689 1930768 0000004661 Q810L9

ENSMUSG0 104071_at transportin 2 (importin 3, karyopherin beta 2b) Tnpo2 -0.5 5685637 AI852433 Mm.220357 212999 Q99LG2 --- NP_663365.1 NM_145390 2384849 0000031691 ENSMUSG0 Q99MK8 /// 104270_at adrenergic receptor kinase, beta 1 Adrbk1 -0.5 5699810 AA982714 Mm.254144 110355 --- NP_570933.1 NM_130863 87940 0000024858 Q7TS64

ENSMUSG0 Q9WVL3 /// 104719_at solute carrier family 12, member 7 Slc12a7 -0.5 5686858 AI182203 Mm.275800 20499 --- NP_035520.1 NM_011390 --- 0000017756 Q6KAS8

UDP-GlcNAc:betaGal beta-1,3-N- 5667279_R ENSMUSG0 160137_at B3gnt1 -0.5 AW260308 Mm.258094 53625 Q9Z222 EC:2.4.1.149 NP_058584.3 NM_016888 1889505 acetylglucosaminyltransferase 1 C 0000051650

5671777_R ENSMUSG0 P26883 /// 160257_at FK506 binding protein 1a Fkbp1a -0.5 X60203 Mm.278458 14225 --- NP_032045.1 NM_008019 --- C 0000032966 Q545E9

5687840_R ENSMUSG0 Q8BLN5 /// 160737_at lanosterol synthase Lss -0.5 AW060927 Mm.55075 16987 EC:5.4.99.7 NP_666118.1 NM_146006 1336155 C 0000033105 Q8VCN8

Q9JMF5 /// ENSMUSG0 Q8BYW4 /// 161243_f_at abhydrolase domain containing 8 Abhd8 -0.5 5723967 AV284333 Mm.276383 64296 --- NP_071864.1 NM_022419 --- 0000007950 Q8R0P8 /// Q9DC79 162482_at ------0.5 5766885 AV109962 ------5663540_R 92608_at cysteine and glycine-rich protein 1 Csrp1 -0.5 D88793 Mm.196484 --- 13007 P97315 --- NP_031817.1 NM_007791 --- C P14434 /// P04228 /// P14435 /// P23150 /// P01910 /// P04227 /// P14436 /// ENSMUSG0 P14437 /// 92866_at histocompatibility 2, class II antigen A, alpha H2-Aa -0.5 5664395 X52643 Mm.235338 14960 --- NP_034508.2 NM_010378 95895 0000036594 P14438 /// Q9TQ71 /// Q9TQ72 /// Q549Q2 /// Q549Q3 /// Q6SR48 /// Q860C1 /// Q8K2X0

F-box and WD-40 domain protein 7, archipelago ENSMUSG0 93667_at Fbxw7 -0.5 5706735 AW120511 Mm.196475 50754 Q8VBV4 --- NP_536353.2 NM_080428 1354695 homolog (Drosophila) 0000028086

ENSMUSG0 O55187 /// 93697_at chromobox homolog 4 (Drosophila Pc class) Cbx4 -0.5 5706984 U63387 Mm.268070 12418 --- NP_031651.1 NM_007625 --- 0000039989 Q8C9Z5

ENSMUSG0 Q61792 /// 93793_at LIM and SH3 protein 1 Lasp1 -0.5 5667169 AW122780 Mm.271967 16796 --- NP_034818.1 NM_010688 --- 0000038366 Q543N3

5687149_R ENSMUSG0 Q00560 /// 94345_at interleukin 6 signal transducer Il6st -0.5 AI843709 Mm.4364 16195 --- NP_034690.2 NM_010560 96560 C 0000021756 Q6PDI9

G-protein signalling modulator 3 (AGS3-like, C. ENSMUSG0 94442_s_at Gpsm3 -0.5 5687559 AF030001 Mm.26584 106512 Q8VDF9 --- NP_598877.1 NM_134116 --- elegans) 0000034786

Q62363 /// ENSMUSG0 94835_f_at tubulin, beta 2 Tubb2 -0.5 5669074 M28739 Mm.246377 22151 Q7TMM9 /// --- NP_033476.1 NM_009450 --- 0000058672 Q99J49

ENSMUSG0 Q9CXH2 /// 95150_at RIKEN cDNA 2810052M02 gene 2810052M02Rik -0.5 5674135 AI852196 Mm.29475 67220 --- NP_075809.1 NM_023320 --- 0000015745 Q9JIY0

ENSMUSG0 Q9EQK1 /// 95693_at isocitrate dehydrogenase 2 (NADP+), mitochondrial Idh2 -0.5 5674400 U51167 Mm.246432 269951 EC:1.1.1.42 NP_766599.1 NM_173011 96414 0000030541 Q8C2R9

ENSMUSG0 O09106 /// 96046_at histone deacetylase 1 Hdac1 -0.5 5670350 X98207 Mm.18359 433759 --- NP_032254.1 NM_008228 --- 0000061062 Q58E49 Q5SWK7 /// Q7TMH4 /// ENSMUSG0 96104_at RIKEN cDNA 3732413I11 gene 3732413I11Rik -0.5 5670653 AI047107 Mm.156771 74315 Q80V78 /// --- NP_083138.1 NM_028862 --- 0000019189 Q8BXX5 /// Q9CXG1

ENSMUSG0 96848_at peptidase (mitochondrial processing) alpha Pmpca -0.5 5675575 AW120756 Mm.250359 66865 Q9DC61 EC:3.4.24.64 NP_775272.1 NM_173180 1918568 0000026926

ENSMUSG0 96865_at Myristoylated alanine rich protein kinase C substrate Marcks -0.5 5675678 M60474 Mm.30059 17118 P26645 --- NP_032564.1 NM_008538 --- 0000069662

97173_f_at similar to MHC H2-L antigen ( LOC545196 -0.5 5712531 M27134 ------545196 ------XP_619452.1 XM_619452 ---

ENSMUSG0 97279_at 3-hydroxyisobutyrate dehydrogenase Hibadh -0.5 5671810 AI837615 Mm.286458 58875 Q99L13 --- NP_663542.1 NM_145567 --- 0000029776

ENSMUSG0 Q8C2B3 /// 97550_at histone deacetylase 7A Hdac7a -0.5 5676909 AW047228 Mm.259829 56233 --- NP_062518.2 NM_019572 1891835 0000022475 Q6KAT4

P48678 /// ENSMUSG0 P11516 /// NP_001002011.1 NM_001002011 /// 98059_s_at lamin A Lmna -0.5 5677047 D49733 Mm.243014 16905 --- 96794 0000028063 Q91WF2 /// /// NP_062263.1 NM_019390 Q9DC21

ENSMUSG0 98354_at pre T-cell antigen receptor alpha Ptcra -0.5 5714589 U16958 Mm.215173 19208 ------NP_035325.1 NM_011195 --- 0000036858 Q6PEB2 /// haloacid dehalogenase-like hydrolase domain ENSMUSG0 98881_at Hdhd2 -0.5 5672614 AI853675 Mm.236127 76987 Q9CXN1 /// --- NP_084102.1 NM_029826 --- containing 2 0000025419 Q9DCF2 Q91ZP3 /// ENSMUSG0 Q8CFH3 /// NP_056578.2 /// NM_015763 /// 98892_at lipin 1 Lpin1 -0.5 5672663 AI846934 Mm.153625 14245 --- 1891340 0000020593 Q80XT6 /// NP_766538.2 NM_172950 Q8CD95

Q64373 /// 99027_at Bcl2-like 1 Bcl2l1 -0.5 5692664 L35049 Mm.238213 --- 12048 O35843 /// --- NP_033873.3 NM_009743 --- Q5HZH3

ENSMUSG0 Q05512 /// 99459_f_at MAP/microtubule affinity-regulating kinase 2 Mark2 -0.5 5692992 X70764 Mm.258986 13728 --- NP_031954.1 NM_007928 99638 0000024969 Q571J8 ENSMUSG0 99574_at zinc and ring finger 2 Znrf2 -0.5 5679147 AI850887 Mm.286149 387524 Q71FD5 --- NP_954594.1 NM_199143 1196246 0000058446

P97364 /// 93557_at selenophosphate synthetase 2 Sephs2 0.78 5666524 U43285 Mm.20294 --- 20768 --- NP_033292.2 NM_009266 108388 Q6PKB1

P23475 /// X-ray repair complementing defective repair in Chinese ENSMUSG0 103036_at Xrcc6 0.8 5684358 M38700 Mm.288809 14375 Q8QZX7 /// --- NP_034377.1 NM_010247 --- hamster cells 6 0000022471 Q6GTV8

5688838_R ENSMUSG0 Q9JIL5 /// 160775_at tubby like protein 4 Tulp4 0.8 AI848591 Mm.28251 68842 --- NP_473381.1 NM_054040 --- C 0000034377 Q69ZK3

ENSMUSG0 94501_at sphingosine-1-phosphate phosphatase 1 Sgpp1 0.83 5673224 AI835784 Mm.280199 81535 Q9JI99 --- NP_109675.1 NM_030750 --- 0000021054

ENSMUSG0 104087_at DNA segment, Chr 10, ERATO Doi 641, expressed D10Ertd641e 0.85 5685675 AI840598 Mm.21793 52717 Q9CPV2 --- NP_079790.1 NM_025514 --- 0000020107 Q9JJK5 /// Q921B3 /// homocysteine-inducible, endoplasmic reticulum stress- ENSMUSG0 95057_at Herpud1 0.85 5673654 AI846938 Mm.29151 64209 Q8C4N0 /// --- NP_071726.1 NM_022331 --- inducible, ubiquitin-like domain member 1 0000031770 Q91WR9 /// Q6A0E4

P52332 /// ENSMUSG0 98911_at Janus kinase 1 Jak1 0.85 5672743 AI837528 Mm.289657 16451 Q8CFX4 /// EC:2.7.1.112 NP_666257.1 NM_146145 96628 0000028530 Q8K0I7

O35621 /// ENSMUSG0 93360_at phosphomannomutase 1 Pmm1 0.88 5666015 AF007267 Mm.18939 29858 Q91W01 /// EC:5.4.2.8 NP_038900.1 NM_013872 1353418 0000022474 Q545Q8

EC:3.1.3.16 ENSMUSG0 Q05922 /// 92758_at dual specificity phosphatase 2 Dusp2 0.9 5705093 U09268 Mm.4729 13537 /// NP_034220.2 NM_010090 --- 0000027368 Q80ZN1 EC:3.1.3.48

5705642_R 93204_r_at RIKEN cDNA 3230402J05 gene 3230402J05Rik 0.9 AW107463 ------108784 ------1918026 C

DNA segment, Chr 15, Wayne State University 75, ENSMUSG0 Q8VC21 /// 162438_f_at D15Wsu75e 0.93 5765650 AV345874 Mm.373551 28075 --- NP_598856.1 NM_134095 106313 expressed 0000022472 Q9CQT7 Q6P234 /// O89080 /// ENSMUSG0 Q643S0 /// 96348_at patatin-like phospholipase domain containing 2 Pnpla2 0.93 5675433 AW121217 Mm.29998 66853 --- NP_080078.1 NM_025802 1914103 0000025509 Q8BJ56 /// Q9D1Q9 /// Q9DCF6 P09793 /// Q8CH94 /// ENSMUSG0 97718_at cytotoxic T-lymphocyte-associated protein 4 Ctla4 0.93 5713510 X05719 Mm.390 12477 Q9Z1A8 /// --- NP_033973.2 NM_009843 88556 0000026011 Q6GTR6 /// Q7TMX1

Q60710 /// ENSMUSG0 Q8C5C0 /// 103080_at SAM domain and HD domain, 1 Samhd1 0.95 5684466 U15635 Mm.248478 56045 --- NP_061339.2 NM_018851 1927468 0000027639 Q543A4 /// Q6ZQM3

DNA segment, Chr 15, Wayne State University 75, ENSMUSG0 Q8VC21 /// 104141_at D15Wsu75e 0.95 5685826 AI850401 Mm.373551 28075 --- NP_598856.1 NM_134095 106313 expressed 0000022472 Q9CQT7

5692891_R ENSMUSG0 Q8K199 /// 160858_at RIKEN cDNA 2310061C15 gene 2310061C15Rik 0.98 AW045976 Mm.4011 66531 --- NP_081120.2 NM_026844 1913781 C 0000014633 Q9D0Y9

ENSMUSG0 O89065 /// 101805_f_at nuclear factor, interleukin 3, regulated Nfil3 1 5724932 U89411 Mm.136604 18030 --- NP_059069.1 NM_017373 109495 0000056749 O08750

Q6KAR5 /// ENSMUSG0 Q8C271 /// 94951_at LAS1-like (S. cerevisiae) Las1l 1 5687731 AI853260 Mm.274318 76130 --- XP_621054.1 XM_621054 --- 0000057421 Q8C742 /// Q8K277

ENSMUSG0 98818_at nuclear receptor subfamily 3, group C, member 1 Nr3c1 1 5715905 X04435 Mm.129481 14815 P06537 --- NP_032199.1 NM_008173 --- 0000024431

Q60769 /// ENSMUSG0 Q810T8 /// 99392_at tumor necrosis factor, alpha-induced protein 3 Tnfaip3 1 5716312 U19463 Mm.116683 21929 --- NP_033423.2 NM_009397 --- 0000019850 Q8C2N2 /// Q7TQD1

ENSMUSG0 P58467 /// 101952_at open reading frame 21 ORF21 1.03 5696314 AI019095 Mm.10628 224440 --- NP_663457.1 NM_145482 2136890 0000022948 Q8K2Z9 161147_f_at ------1.03 5720409 AV221100 ------P60710 /// O89054 /// ENSMUSG0 Q61276 /// 95705_s_at actin, beta, cytoplasmic Actb 1.03 5674483 J04181 Mm.297 11461 --- NP_031419.1 NM_007393 --- 0000029580 Q6ZWM3 /// Q99NC5 /// Q6IWE2 Q9JLU3 /// ENSMUSG0 100929_at L-threonine dehydrogenase Tdh 1.05 5695139 AW046351 Mm.6128 58865 Q8K3F7 /// EC:1.1.1.103 NP_067455.4 NM_021480 --- 0000021953 Q6PD91 ENSMUSG0 103429_i_at expressed sequence AL024210 AL024210 1.05 5684850 AW125330 Mm.291504 104923 Q99JT9 --- NP_598813.1 NM_134052 --- 0000020629 Q9EP90 /// Q9R115 /// Q8BG60 /// 5682128_R ENSMUSG0 NP_001009935.1 NM_001009935 /// 160547_s_at thioredoxin interacting protein Txnip 1.05 AI839138 Mm.271877 56338 Q8BGQ0 /// ------C 0000038393 /// NP_076208.1 NM_023719 Q8K2B2 /// Q91X82 /// Q9DC00

ENSMUSG0 P15092 /// interferon activated gene 204 /// interferon activated 15951 /// 101847 /// Ifi204 /// Ifi205 /// 0000026538 Q8BYE7 /// NP_032355.1 /// NM_008329 /// gene 205 /// myeloid cell nuclear differentiation antigen 226695 /// 101847 /// 94224_s_at Mnda /// 1.05 5668363 M74123 Mm.255414 /// Q8C4X3 /// --- NP_766236.2 /// NM_172648 /// /// similar to Interferon-activatable protein 205 (IFI-205) 381308 /// 101847 /// LOC545386 ENSMUSG0 Q8CGE8 /// XP_619702.1 XM_619702 (D3 protein) 545386 101847 0000054203 Q921V9

ENSMUSG0 P97370 /// 99579_at ATPase, Na+/K+ transporting, beta 3 polypeptide Atp1b3 1.05 5679162 U59761 Mm.424 11933 EC:3.6.3.9 NP_031528.1 NM_007502 --- 0000032412 Q544Q7

P15092 /// ENSMUSG0 98465_f_at interferon activated gene 204 Ifi204 1.08 5691803 M31419 Mm.212870 15951 Q8C4X3 /// --- NP_032355.1 NM_008329 --- 0000026538 Q921V9

ENSMUSG0 103799_at myotubularin related protein 9 Mtmr9 1.15 5685234 AF073881 Mm.374857 210376 Q9Z2D0 --- NP_808262.1 NM_177594 --- 0000035078

ENSMUSG0 92480_f_at zinc finger protein 53 Zfp53 1.15 5703713 AB024004 Mm.42140 24132 Q9Z117 --- NP_038871.1 NM_013843 99200 0000057409

O70254 /// ENSMUSG0 Q69ZI1 /// NP_067481.1 /// NM_021506 /// 161061_r_at SH3 multiple domains 2 Sh3md2 1.18 5705472 AA793086 Mm.27949 59009 ------0000031642 Q6P9M8 /// NP_941371.1 NM_198678 Q8BR66 Q8C2V2 /// potassium channel tetramerisation domain containing 104735_at Kctd12 1.2 5686953 AI842065 Mm.246466 --- 239217 Q8CBQ4 /// --- NP_808383.2 NM_177715 2145823 12 Q69ZA6

5703625_R ENSMUSG0 92444_f_at zinc finger protein 1 Zfp1 1.2 X16493 Mm.4184 22640 P08042 --- NP_035872.1 NM_011742 99154 C 0000055835

P16872 /// ENSMUSG0 Q8C9W4 /// 99030_at interleukin 7 receptor Il7r 1.2 5692712 M29697 Mm.389 16197 --- NP_032398.3 NM_008372 --- 0000003882 Q5FW78 /// Q9R0C1 5703625_R ENSMUSG0 92443_i_at zinc finger protein 1 Zfp1 1.23 X16493 Mm.4184 22640 P08042 --- NP_035872.1 NM_011742 99154 C 0000055835

O54918 /// NP_033884.1 /// NM_009754 /// ENSMUSG0 99419_g_at BCL2-like 11 (apoptosis facilitator) Bcl2l11 1.23 5716339 AF032459 Mm.141083 12125 Q542N5 /// --- NP_997563.1 /// NM_207680 /// --- 0000027381 Q6PEB3 NP_997564.1 NM_207681 RIKEN cDNA A130095M15 gene /// T-cell receptor A130095M15Rik 319928 /// 2442996 /// 102695_at 1.25 5696918 AF021335 Mm.210785 --- Q6PKA9 ------gamma, constant region /// Tcrg-C 432729 2442996 P60710 /// O89054 /// ENSMUSG0 Q61276 /// 101578_f_at actin, beta, cytoplasmic Actb 1.28 5682871 M12481 Mm.297 11461 --- NP_031419.1 NM_007393 --- 0000029580 Q6ZWM3 /// Q99NC5 /// Q6IWE2 10 days neonate cerebellum cDNA, RIKEN full-length 161050_at enriched library, clone:6530415D11 product:unknown --- 1.33 5705202 AI504506 Mm.292000 ------EST, full insert sequence 5688397_R ENSMUSG0 95571_at solute carrier family 30 (zinc transporter), member 4 Slc30a4 1.33 AF004100 Mm.27801 22785 O35149 --- NP_035904.2 NM_011774 --- C 0000005802

ENSMUSG0 P61969 /// 98122_at LIM domain only 4 Lmo4 1.33 5677402 AF074600 Mm.29187 16911 --- NP_034853.1 NM_010723 109360 0000028266 Q542S1

ENSMUSG0 Q91YR9 /// 98440_at leukotriene B4 12-hydroxydehydrogenase Ltb4dh 1.33 5691634 AA596710 Mm.34497 67103 --- NP_080244.1 NM_025968 1914353 0000028378 Q9CPS1

Q9Z2C4 /// Q8CIU3 /// Q8CIU4 /// ENSMUSG0 Q8CIU5 /// 103264_at myotubularin related protein 1 Mtmr1 1.35 5697600 AF073997 Mm.219672 53332 --- NP_058681.1 NM_016985 1858271 0000015214 Q8CIU6 /// Q8CIU7 /// Q8BQ73 /// Q8C489 O54918 /// NP_033884.1 /// NM_009754 /// ENSMUSG0 100988_at BCL2-like 11 (apoptosis facilitator) Bcl2l11 1.43 5695336 AA796690 Mm.141083 12125 Q542N5 /// --- NP_997563.1 /// NM_207680 /// --- 0000027381 Q6PEB3 NP_997564.1 NM_207681

ENSMUSG0 101560_at embigin Emb 1.43 5682749 AW061330 Mm.274926 13723 P21995 --- NP_034460.2 NM_010330 --- 0000021728 Q91XL9 /// Q6DFU6 /// ENSMUSG0 Q6PG70 /// 93316_at oxysterol binding protein-like 1A Osbpl1a 1.48 5665755 AB017026 Mm.259470 64291 --- NP_997413.2 NM_207530 1927551 0000044252 Q673L8 /// Q8BTJ6 /// Q8K2D2 ENSMUSG0 94920_at pyridoxine 5'-phosphate oxidase Pnpo 1.48 5669535 AI854028 Mm.254704 103711 Q91XF0 EC:1.4.3.5 NP_598782.1 NM_134021 --- 0000018659

P23949 /// ENSMUSG0 NP_001001806.1 NM_001001806 /// 93944_r_at zinc finger protein 36, C3H type-like 2 Zfp36l2 1.53 5708002 M58564 Mm.259321 12193 Q9EQL7 /// ------0000045817 /// NP_031591.2 NM_007565 Q9EQL8 102744_at T cell receptor gamma chain Tcrg 1.63 5683902 X00697 Mm.350873 --- 434531 Q7TN06 ------ENSMUSG0 103460_at DNA-damage-inducible transcript 4 Ddit4 1.75 5697781 AI849939 Mm.21697 74747 Q9D3F7 --- NP_083359.1 NM_029083 --- 0000020108

ENSMUSG0 93195_at malignant fibrous histiocytoma amplified sequence 1 Mfhas1 1.78 5705582 AI957146 Mm.103246 52065 Q8C4N5 --- XP_356068.3 XM_356068 --- 0000070056 P23949 /// 5672061_R ENSMUSG0 NP_001001806.1 NM_001001806 /// 160273_at Zinc finger protein 36, C3H type-like 2 Zfp36l2 1.83 AA960603 Mm.259321 12193 Q9EQL7 /// ------C 0000045817 /// NP_031591.2 NM_007565 Q9EQL8

ENSMUSG0 94297_at FK506 binding protein 5 Fkbp5 1.83 5668739 U16959 Mm.276405 14229 Q64378 EC:5.2.1.8 NP_034350.1 NM_010220 --- 0000024222

92778_i_at ------2.2 5663859 Z22552 ------Q9ER51 /// ENSMUSG0 104058_at RIKEN cDNA 1110018J12 gene 1110018J12Rik 2.23 5685607 AW047528 Mm.271817 73825 Q8BHS9 /// --- NP_082934.2 NM_028658 1921075 0000034709 Q9D1A1 5683721_R ENSMUSG0 160587_at tumor suppressing subtransferable candidate 1 Tssc1 2.48 AW050018 Mm.273724 380752 Q8K0G5 --- NP_958745.1 NM_201357 1289332 C 0000036613

ENSMUSG0 96553_at G-protein coupled receptor 65 Gpr65 2.55 5710426 U39827 Mm.207528 14744 Q61038 --- NP_032178.1 NM_008152 108031 0000021886

P23949 /// ENSMUSG0 NP_001001806.1 NM_001001806 /// 93943_f_at zinc finger protein 36, C3H type-like 2 Zfp36l2 2.6 5708002 M58564 Mm.259321 12193 Q9EQL7 /// ------0000045817 /// NP_031591.2 NM_007565 Q9EQL8

ENSMUSG0 O89065 /// 102955_at nuclear factor, interleukin 3, regulated Nfil3 2.7 5697193 U83148 Mm.136604 18030 --- NP_059069.1 NM_017373 --- 0000056749 O08750

161571_f_at ------3.13 5734715 AV239653 ------

ENSMUSG0 93928_f_at RIKEN cDNA 9130020O15 gene 9130020O15Rik 3.15 5707946 AF043689 --- 353085 ------NP_001013406.1 NM_001013388 2655165 0000068419

92202_g_at zinc finger and BTB domain containing 16 Zbtb16 3.43 5701379 AI553024 Mm.354735 --- 235320 Q8C3J8 --- XP_134826.4 XM_134826 --- ENSMUSG0 93416_at tumor necrosis factor (ligand) superfamily, member 11 Tnfsf11 3.98 5705965 AF019048 Mm.249221 21943 O35235 --- NP_035743.1 NM_011613 --- 0000022015

92779_f_at ------4.38 5663859 Z22552 ------

ENSMUSG0 95024_at ubiquitin specific protease 18 Usp18 4.43 5688094 AW047653 Mm.326911 24110 Q9WTV6 --- NP_036039.1 NM_011909 --- 0000030107

92780_f_at ------6 5663860 M90535 ------column 15 column 16 column 17 column 18 column 19

Gene Ontology Biological Process Gene Ontology Cellular Component Gene Ontology Molecular Function Pathway InterPro

IPR001849 // Pleckstrin------like 122 // negative regulation of transcription from RNA polymerase II 5515 // protein binding // inferred from physical interaction /// 19904 // IPR001092 // Basic helix- promoter // inferred from direct assay /// 7507 // heart development // 5634 // nucleus // inferred from electronic annotation specific binding // inferred from direct assay /// 30528 // --- loop-helix dimerization inferred from genetic interaction /// 45449 // regulation of transcription // transcription regulator activity // inferred from electronic annotation domain bHLH inferred from electronic annotation

45210 // FasL biosynthesis // inferred from direct assay ------

4772 // sterol O-acyltransferase activity // inferred from electronic 6629 // lipid metabolism // inferred from electronic annotation /// 8202 // 5783 // endoplasmic reticulum // inferred from electronic annotation /// annotation /// 8415 // acyltransferase activity // inferred from electronic Statin_Pathway_PharmGK steroid metabolism // inferred from electronic annotation /// 8203 // --- 16021 // integral to membrane // traceable author statement annotation /// 16740 // transferase activity // inferred from electronic B // GenMAPP cholesterol metabolism // inferred from electronic annotation annotation 5615 // extracellular space // traceable author statement /// 5923 // tight IPR004031 // PMP- junction // inferred from electronic annotation /// 16020 // membrane // --- 5198 // structural molecule activity // inferred from electronic annotation --- 22/EMP/MP20 and inferred from electronic annotation /// 16021 // integral to membrane // claudin family traceable author statement

7155 // cell adhesion // inferred from sequence or structural similarity --- 5515 // protein binding // inferred from electronic annotation --- IPR007955 // Bystin

6629 // lipid metabolism // inferred from electronic annotation /// 6810 // IPR006209 // EGF-like transport // inferred from electronic annotation /// 6869 // lipid transport // 4872 // receptor activity // inferred from electronic annotation /// 5041 // low- domain /// IPR002172 // 5615 // extracellular space // traceable author statement /// 5768 // Wnt_Signaling // inferred from electronic annotation /// 6897 // endocytosis // inferred from density lipoprotein receptor activity // inferred from direct assay /// 5319 // Low density lipoprotein- endosome // inferred from direct assay /// 5905 // coated pit // inferred from GenMAPP /// electronic annotation /// 8202 // steroid metabolism // inferred from lipid transporter activity // inferred from electronic annotation /// 5509 // receptor, class A /// electronic annotation /// 16020 // membrane // inferred from electronic Statin_Pathway_PharmGK electronic annotation /// 8203 // cholesterol metabolism // inferred from calcium ion binding // inferred from electronic annotation /// 5515 // protein IPR000033 // Low- annotation /// 16021 // integral to membrane // traceable author statement B // GenMAPP electronic annotation /// 42632 // cholesterol homeostasis // inferred from binding // inferred from physical interaction density lipoprotein mutant phenotype receptor, YWTD repeat

4089 // carbonate dehydratase activity // inferred from electronic 6730 // one-carbon compound metabolism // inferred from electronic annotation /// 8270 // zinc ion binding // inferred from electronic annotation Nitrogen metabolism // IPR001148 // Carbonic --- annotation /// 16829 // lyase activity // inferred from electronic annotation /// 46872 // KEGG anhydrase, eukaryotic metal ion binding // inferred from electronic annotation 3677 // DNA binding // inferred from direct assay /// 3700 // transcription factor activity // inferred from direct assay /// 3707 // steroid 1657 // ureteric bud development // inferred from mutant phenotype /// receptor activity // inferred from electronic annotation /// 3708 // retinoic IPR000536 // Ligand- 6350 // transcription // inferred from electronic annotation /// 6355 // acid receptor activity // inferred from direct assay /// 3708 // retinoic acid binding domain of regulation of transcription, DNA-dependent // inferred from direct assay /// 5634 // nucleus // inferred from direct assay /// 5737 // cytoplasm // inferred receptor activity // inferred from sequence or structural similarity /// 4872 // Nuclear_Receptors // nuclear hormone 45449 // regulation of transcription // inferred from direct assay /// 45944 // from direct assay receptor activity // inferred from electronic annotation /// 4879 // ligand- GenMAPP receptor /// IPR001628 // positive regulation of transcription from RNA polymerase II promoter // dependent nuclear receptor activity // inferred from direct assay /// 5515 // Zn-finger, C4-type inferred from genetic interaction protein binding // inferred from physical interaction /// 30528 // transcription steroid receptor regulator activity // inferred from direct assay /// 46872 // metal ion binding // inferred from electronic annotation

3676 // nucleic acid binding // inferred from electronic annotation /// 3677 // 6350 // transcription // inferred from electronic annotation /// 6355 // DNA binding // inferred from electronic annotation /// 8270 // zinc ion IPR007087 // Zn-finger, regulation of transcription, DNA-dependent // inferred from electronic 5634 // nucleus // inferred from electronic annotation --- binding // inferred from electronic annotation /// 46872 // metal ion binding C2H2 type annotation // inferred from electronic annotation ------3676 // nucleic acid binding // inferred from electronic annotation /// 3677 // 6350 // transcription // inferred from electronic annotation /// 6355 // DNA binding // inferred from electronic annotation /// 8270 // zinc ion IPR007087 // Zn-finger, regulation of transcription, DNA-dependent // inferred from electronic 5634 // nucleus // inferred from electronic annotation --- binding // inferred from electronic annotation /// 46872 // metal ion binding C2H2 type annotation // inferred from electronic annotation

------

6631 // fatty acid metabolism // inferred from sequence or structural similarity /// 6694 // steroid biosynthesis // inferred from electronic 5783 // endoplasmic reticulum // inferred from sequence or structural 254 // C-4 methylsterol oxidase activity // inferred from sequence or annotation /// 8152 // metabolism // inferred from sequence or structural similarity /// 5886 // plasma membrane // inferred from sequence or structural similarity /// 3824 // catalytic activity // inferred from sequence or Cholesterol_Biosynthesis // IPR006088 // Sterol similarity /// 8202 // steroid metabolism // inferred from sequence or structural similarity /// 16021 // integral to membrane // traceable author structural similarity /// 16491 // oxidoreductase activity // inferred from GenMAPP desaturase structural similarity /// 8610 // lipid biosynthesis // inferred from electronic statement sequence or structural similarity annotation /// 16126 // sterol biosynthesis // inferred from sequence or structural similarity

6338 // chromatin remodeling // inferred from physical interaction 118 // histone deacetylase complex // inferred from physical interaction 5515 // protein binding // inferred from physical interaction ------

5634 // nucleus // inferred from sequence or structural similarity /// 5737 // IPR006762 // Gtr1/RagA --- 5515 // protein binding // inferred from sequence or structural similarity --- cytoplasm // inferred from sequence or structural similarity G protein

5615 // extracellular space // inferred from sequence or structural similarity 6679 // glucosylceramide biosynthesis // inferred from sequence or 8120 // ceramide glucosyltransferase activity // inferred from electronic /// 5624 // membrane fraction // inferred from sequence or structural structural similarity /// 6688 // glycosphingolipid biosynthesis // inferred from annotation /// 16740 // transferase activity // inferred from electronic similarity /// 5737 // cytoplasm // inferred from sequence or structural ------sequence or structural similarity /// 8544 // epidermis development // annotation /// 16757 // transferase activity, transferring glycosyl groups // similarity /// 5783 // endoplasmic reticulum // inferred from electronic inferred from sequence or structural similarity inferred from electronic annotation annotation /// 16021 // integral to membrane // traceable author statement 4497 // monooxygenase activity // inferred from electronic annotation /// 6118 // electron transport // inferred from electronic annotation /// 6725 // 5615 // extracellular space // traceable author statement /// 16021 // 4506 // squalene monooxygenase activity // inferred from electronic Cholesterol_Biosynthesis // IPR007087 // Zn-finger, aromatic compound metabolism // inferred from electronic annotation /// integral to membrane // traceable author statement annotation /// 16491 // oxidoreductase activity // inferred from electronic GenMAPP C2H2 type 8152 // metabolism // inferred from electronic annotation annotation 4222 // metalloendopeptidase activity // inferred from electronic annotation /// 4234 // macrophage elastase activity // inferred from electronic IPR001818 // Peptidase annotation /// 8233 // peptidase activity // inferred from electronic M10A and M12B, 5578 // (sensu Metazoa) // inferred from electronic Matrix_Metalloproteinases 6508 // proteolysis and peptidolysis // inferred from electronic annotation annotation /// 8237 // metallopeptidase activity // inferred from electronic matrixin and adamalysin annotation /// 5615 // extracellular space // traceable author statement // GenMAPP annotation /// 8270 // zinc ion binding // inferred from electronic annotation /// IPR000585 // /// 16787 // hydrolase activity // inferred from electronic annotation /// Hemopexin repeat 46872 // metal ion binding // inferred from electronic annotation 1764 // neuron migration // inferred from mutant phenotype /// 6915 // apoptosis // inferred from electronic annotation /// 7409 // axonogenesis // inferred from direct assay /// 7411 // axon guidance // inferred from direct assay /// 7411 // axon guidance // inferred from mutant phenotype /// 5578 // extracellular matrix (sensu Metazoa) // inferred from electronic 5198 // structural molecule activity // inferred from sequence or structural ------30334 // regulation of cell migration // inferred from direct assay /// 30517 // annotation /// 5615 // extracellular space // traceable author statement similarity /// 5515 // protein binding // inferred from physical interaction negative regulation of axon extension // inferred from direct assay /// 40023 // nuclear positioning // inferred from direct assay /// 45773 // positive regulation of axon extension // inferred from direct assay 166 // nucleotide binding // inferred from electronic annotation /// 3677 // 6259 // DNA metabolism // inferred from sequence or structural similarity /// DNA binding // inferred from sequence or structural similarity /// 3918 // IPR000038 // Cell 6265 // DNA topological change // inferred from sequence or structural DNA topoisomerase (ATP-hydrolyzing) activity // inferred from sequence ------division/GTP binding similarity /// 7049 // cell cycle // inferred from electronic annotation /// 51301 or structural similarity /// 5524 // ATP binding // inferred from sequence or protein // cell division // inferred from electronic annotation structural similarity /// 5525 // GTP binding // inferred from electronic annotation ------Cell_Cycle_KEGG // 74 // regulation of cell cycle // inferred from direct assay /// 7049 // cell 4693 // cyclin-dependent protein kinase activity // inferred from direct GenMAPP /// IPR004367 // Cyclin, C- cycle // inferred from electronic annotation /// 7165 // // assay /// 5515 // protein binding // inferred from physical interaction /// G1_to_S_cell_cycle_React terminal /// IPR006671 // inferred from direct assay /// 42098 // T cell proliferation // inferred from 5634 // nucleus // inferred from electronic annotation 16538 // cyclin-dependent protein kinase regulator activity // inferred from ome // GenMAPP /// Cyclin, N-terminal mutant phenotype /// 51301 // cell division // inferred from electronic electronic annotation Wnt_Signaling // domain annotation GenMAPP 6694 // steroid biosynthesis // inferred from electronic annotation /// 6695 // 4163 // diphosphomevalonate decarboxylase activity // inferred from cholesterol biosynthesis // inferred from sequence or structural similarity /// sequence or structural similarity /// 5524 // ATP binding // inferred from 8299 // isoprenoid biosynthesis // inferred from electronic annotation /// Cholesterol_Biosynthesis // IPR006204 // GHMP --- sequence or structural similarity /// 16301 // kinase activity // inferred from 8610 // lipid biosynthesis // inferred from electronic annotation /// 16126 // GenMAPP kinase electronic annotation /// 16829 // lyase activity // inferred from sequence or sterol biosynthesis // inferred from sequence or structural similarity /// structural similarity 16310 // phosphorylation // inferred from electronic annotation IPR003877 // 7242 // intracellular signaling cascade // inferred from sequence or ------SPla/RYanodine structural similarity receptor SPRY 5783 // endoplasmic reticulum // inferred from direct assay /// 16020 // 4768 // stearoyl-CoA 9-desaturase activity // inferred from electronic 6633 // fatty acid biosynthesis // inferred from electronic annotation /// 8610 Fatty_Acid_Synthesis // IPR005804 // Fatty acid membrane // inferred from electronic annotation /// 16021 // integral to annotation /// 5506 // iron ion binding // inferred from electronic annotation // lipid biosynthesis // inferred from electronic annotation GenMAPP desaturase membrane // traceable author statement /// 16491 // oxidoreductase activity // inferred from electronic annotation

5576 // extracellular region // inferred from electronic annotation /// 5578 // IPR006209 // EGF-like 5509 // calcium ion binding // inferred from electronic annotation /// 5515 // 7155 // cell adhesion // inferred from electronic annotation extracellular matrix (sensu Metazoa) // inferred from electronic annotation --- domain /// IPR000020 // protein binding // inferred from physical interaction /// 5615 // extracellular space // inferred from electronic annotation Anaphylatoxin/fibulin

160 // two-component signal transduction system (phosphorelay) // inferred from sequence or structural similarity /// 6355 // regulation of 155 // two-component sensor molecule activity // inferred from sequence transcription, DNA-dependent // inferred from sequence or structural 5624 // membrane fraction // inferred from sequence or structural similarity or structural similarity /// 4871 // signal transducer activity // inferred from similarity /// 6810 // transport // inferred from electronic annotation /// 6811 /// 5635 // nuclear membrane // inferred from direct assay /// 5737 // sequence or structural similarity /// 5216 // ion channel activity // inferred IPR005821 // Ion // ion transport // inferred from sequence or structural similarity /// 6812 // cytoplasm // inferred from direct assay /// 5886 // plasma membrane // from electronic annotation /// 5244 // voltage-gated ion channel activity // transport protein /// cation transport // inferred from sequence or structural similarity /// 6813 // inferred from direct assay /// 5887 // integral to plasma membrane // inferred from sequence or structural similarity /// 5249 // voltage-gated IPR000595 // Cyclic --- potassium ion transport // inferred from electronic annotation /// 6936 // inferred from electronic annotation /// 8076 // voltage-gated potassium potassium channel activity // inferred from sequence or structural similarity nucleotide-binding muscle contraction // inferred from sequence or structural similarity /// 7165 channel complex // inferred from sequence or structural similarity /// 16020 /// 5251 // delayed rectifier potassium channel activity // inferred from domain /// IPR001610 // // signal transduction // inferred from sequence or structural similarity /// // membrane // inferred from sequence or structural similarity /// 16021 // sequence or structural similarity /// 5261 // cation channel activity // inferred PAC motif 8015 // circulation // inferred from sequence or structural similarity /// 8016 integral to membrane // traceable author statement from sequence or structural similarity /// 5267 // potassium channel activity // regulation of heart contraction rate // inferred from sequence or // inferred from electronic annotation structural similarity

5215 // transporter activity // inferred from electronic annotation /// 5386 // 6810 // transport // inferred from electronic annotation /// 15711 // organic 5887 // integral to plasma membrane // inferred from electronic annotation carrier activity // inferred from electronic annotation /// 15293 // symporter ------anion transport // inferred from electronic annotation /// 16021 // integral to membrane // traceable author statement activity // inferred from electronic annotation /// 15355 // monocarboxylate porter activity // inferred from electronic annotation ------6350 // transcription // inferred from electronic annotation /// 6355 // IPR001356 // Homeobox 5634 // nucleus // inferred from electronic annotation /// 5667 // 3677 // DNA binding // inferred from electronic annotation /// 3700 // regulation of transcription, DNA-dependent // inferred from electronic --- /// IPR000327 // POU transcription factor complex // inferred from electronic annotation transcription factor activity // inferred from electronic annotation annotation domain IPR003877 // 7242 // intracellular signaling cascade // inferred from sequence or ------SPla/RYanodine structural similarity receptor SPRY 1501 // skeletal development // inferred from mutant phenotype /// 6350 // 3677 // DNA binding // inferred from direct assay /// 3700 // transcription IPR000040 // Acute transcription // inferred from electronic annotation /// 6355 // regulation of factor activity // inferred from direct assay /// 5515 // protein binding // 5634 // nucleus // inferred from electronic annotation --- myeloid leukemia 1 transcription, DNA-dependent // inferred from direct assay /// 30182 // inferred from physical interaction /// 5524 // ATP binding // inferred from protein (AML 1)/Runt neuron differentiation // inferred from mutant phenotype electronic annotation

1558 // regulation of cell growth // inferred from electronic annotation /// 1932 // regulation of protein amino acid phosphorylation // inferred from direct assay /// 6512 // ubiquitin cycle // inferred from electronic annotation /// 7242 // intracellular signaling cascade // inferred from electronic annotation /// 7259 // JAK-STAT cascade // inferred from direct assay /// 9968 // negative regulation of signal transduction // inferred from electronic 5515 // protein binding // inferred from physical interaction /// 19210 // annotation /// 19221 // cytokine and chemokine mediated signaling ------IPR000980 // SH2 motif kinase inhibitor activity // inferred from direct assay pathway // inferred from direct assay /// 19221 // cytokine and chemokine mediated signaling pathway // inferred from mutant phenotype /// 42518 // negative regulation of tyrosine phosphorylation of Stat3 protein // inferred from direct assay /// 46426 // negative regulation of JAK-STAT cascade // inferred from mutant phenotype /// 46627 // negative regulation of insulin receptor signaling pathway // inferred from direct assay IPR001562 // Tec/Btk domain /// IPR001849 // Pleckstrin-like /// 5096 // GTPase activator activity // inferred from electronic annotation /// MAPK_Cascade // 7242 // intracellular signaling cascade // inferred from electronic annotation --- IPR000008 // 46872 // metal ion binding // inferred from electronic annotation GenMAPP /// IPR001936 // Ras GTPase-activating protein 16020 // membrane // inferred from sequence or structural similarity /// 5452 // inorganic anion exchanger activity // inferred from sequence or 6820 // anion transport // inferred from sequence or structural similarity ------16021 // integral to membrane // traceable author statement structural similarity 5634 // nucleus // inferred from electronic annotation /// 5874 // microtubule IPR009786 // Thyroid 7026 // negative regulation of microtubule depolymerization // inferred from // inferred from electronic annotation /// 15630 // microtubule cytoskeleton 5515 // protein binding // inferred from physical interaction --- hormone-inducible genetic interaction // inferred from direct assay hepatic Spot 14

6260 // DNA replication // inferred from electronic annotation 5634 // nucleus // inferred from electronic annotation ------

1708 // cell fate specification // inferred from mutant phenotype /// 1763 // branching morphogenesis // inferred from mutant phenotype /// 1837 // epithelial to mesenchymal transition // inferred from mutant phenotype /// 6350 // transcription // inferred from electronic annotation /// 6355 // regulation of transcription, DNA-dependent // inferred from electronic annotation /// 6357 // regulation of transcription from RNA polymerase II 3677 // DNA binding // inferred from sequence or structural similarity /// IPR006209 // EGF-like promoter // inferred from genetic interaction /// 7219 // Notch signaling 3682 // chromatin binding // inferred from direct assay /// 3700 // 5615 // extracellular space // traceable author statement /// 16020 // domain /// IPR002110 // pathway // inferred from mutant phenotype /// 7275 // development // transcription factor activity // inferred from sequence or structural similarity membrane // inferred from electronic annotation /// 16021 // integral to --- Ankyrin /// IPR000800 // inferred from electronic annotation /// 7368 // determination of left/right /// 4872 // receptor activity // inferred from electronic annotation /// 5509 // membrane // inferred from electronic annotation Notch (DSL) domain /// symmetry // inferred from mutant phenotype /// 7386 // compartment calcium ion binding // inferred from electronic annotation /// 5515 // protein IPR010660 // NOTCH specification // inferred from mutant phenotype /// 7409 // axonogenesis // binding // inferred from physical interaction inferred from direct assay /// 7492 // endoderm development // inferred from mutant phenotype /// 7507 // heart development // inferred from mutant phenotype /// 8284 // positive regulation of cell proliferation // inferred from genetic interaction /// 8544 // epidermis development // inferred from genetic interaction /// 30154 // cell differentiation // inferred fro 166 // nucleotide binding // inferred from electronic annotation /// 4672 // protein kinase activity // inferred from electronic annotation /// 4674 // 6468 // protein amino acid phosphorylation // inferred from electronic protein serine/threonine kinase activity // inferred from electronic annotation /// 7623 // circadian rhythm // traceable author statement /// annotation /// 4713 // protein-tyrosine kinase activity // inferred from Wnt_Signaling // IPR000719 // Protein --- 16055 // Wnt receptor signaling pathway // inferred from electronic sequence or structural similarity /// 5524 // ATP binding // inferred from GenMAPP kinase annotation electronic annotation /// 16301 // kinase activity // inferred from electronic annotation /// 16740 // transferase activity // inferred from electronic annotation 1568 // blood vessel development // inferred from mutant phenotype /// 6694 // steroid biosynthesis // inferred from electronic annotation /// 6695 // cholesterol biosynthesis // inferred from electronic annotation /// 8610 // IPR001171 // 5783 // endoplasmic reticulum // inferred from electronic annotation /// 16491 // oxidoreductase activity // inferred from electronic annotation /// Cholesterol_Biosynthesis // lipid biosynthesis // inferred from electronic annotation /// 16126 // sterol ERG4/ERG24 16020 // membrane // inferred from electronic annotation /// 16021 // 47598 // 7-dehydrocholesterol reductase activity // inferred from direct GenMAPP /// Biosynthesis biosynthesis // inferred from mutant phenotype /// 30154 // cell ergosterol biosynthesis integral to membrane // traceable author statement assay of steroids // KEGG differentiation // inferred from mutant phenotype /// 30324 // lung protein development // inferred from mutant phenotype /// 42127 // regulation of cell proliferation // inferred from mutant phenotype

6694 // steroid biosynthesis // inferred from electronic annotation /// 6695 // 4161 // dimethylallyltranstransferase activity // inferred from electronic cholesterol biosynthesis // inferred from electronic annotation /// 8299 // annotation /// 4337 // geranyltranstransferase activity // inferred from Cholesterol_Biosynthesis // IPR000092 // Polyprenyl isoprenoid biosynthesis // inferred from electronic annotation /// 8610 // --- electronic annotation /// 16740 // transferase activity // inferred from GenMAPP synthetase lipid biosynthesis // inferred from electronic annotation /// 16126 // sterol electronic annotation biosynthesis // inferred from electronic annotation 6350 // transcription // inferred from electronic annotation /// 6355 // regulation of transcription, DNA-dependent // inferred from electronic 3676 // nucleic acid binding // inferred from electronic annotation /// 3677 // annotation /// 30282 // bone mineralization // inferred from mutant DNA binding // inferred from electronic annotation /// 8270 // zinc ion IPR007087 // Zn-finger, 5634 // nucleus // inferred from electronic annotation --- phenotype /// 45449 // regulation of transcription // inferred from mutant binding // inferred from electronic annotation /// 46872 // metal ion binding C2H2 type phenotype /// 45672 // positive regulation of osteoclast differentiation // // inferred from electronic annotation inferred from mutant phenotype 4791 // thioredoxin-disulfide reductase activity // inferred from direct assay IPR001327 // FAD- /// 4791 // thioredoxin-disulfide reductase activity // inferred from sequence dependent pyridine or structural similarity /// 15036 // disulfide oxidoreductase activity // nucleotide-disulphide 6118 // electron transport // inferred from electronic annotation /// 6125 // 5737 // cytoplasm // inferred from sequence or structural similarity /// 5829 inferred from electronic annotation /// 16491 // oxidoreductase activity // Pyrimidine metabolism // oxidoreductase /// thioredoxin pathway // inferred from direct assay /// 8283 // cell proliferation // cytosol // inferred from direct assay inferred from electronic annotation /// 16654 // oxidoreductase activity, KEGG IPR004099 // Pyridine // inferred from mutant phenotype acting on NADH or NADPH, disulfide as acceptor // inferred from nucleotide-disulphide electronic annotation /// 50660 // FAD binding // inferred from electronic oxidoreductase annotation dimerisation domain

6350 // transcription // inferred from electronic annotation /// 6355 // 5634 // nucleus // inferred from direct assay /// 5667 // transcription factor 3677 // DNA binding // inferred from electronic annotation /// 3700 // IPR000910 // HMG1/2 regulation of transcription, DNA-dependent // inferred from electronic --- complex // inferred from electronic annotation transcription factor activity // inferred from electronic annotation (high mobility group) box annotation

6338 // chromatin remodeling // inferred from physical interaction /// 6350 // 3677 // DNA binding // inferred from electronic annotation /// 3714 // IPR002893 // Zn-finger, transcription // inferred from electronic annotation /// 6355 // regulation of 5634 // nucleus // inferred from direct assay /// 5737 // cytoplasm // inferred transcription corepressor activity // inferred from direct assay /// 5515 // MYND type /// transcription, DNA-dependent // inferred from electronic annotation /// --- from direct assay protein binding // inferred from physical interaction /// 46872 // metal ion IPR001214 // Nuclear 7507 // heart development // inferred from mutant phenotype /// 16481 // binding // inferred from electronic annotation protein SET negative regulation of transcription // inferred from direct assay 5615 // extracellular space // traceable author statement /// 5887 // integral 4872 // receptor activity // inferred from electronic annotation /// 5315 // 6810 // transport // inferred from electronic annotation /// 6817 // phosphate to plasma membrane // inferred from electronic annotation /// 16020 // inorganic phosphate transporter activity // inferred from sequence or IPR001204 // Phosphate --- transport // inferred from sequence or structural similarity membrane // inferred from sequence or structural similarity /// 16021 // structural similarity /// 5386 // carrier activity // inferred from electronic transporter integral to membrane // traceable author statement annotation 6350 // transcription // inferred from electronic annotation /// 6355 // regulation of transcription, DNA-dependent // inferred from electronic 3676 // nucleic acid binding // inferred from electronic annotation /// 3677 // annotation /// 7638 // mechanosensory behavior // inferred from mutant DNA binding // inferred from electronic annotation /// 8270 // zinc ion IPR007087 // Zn-finger, 5634 // nucleus // inferred from electronic annotation --- phenotype /// 42472 // inner ear morphogenesis // inferred from mutant binding // inferred from electronic annotation /// 46872 // metal ion binding C2H2 type phenotype /// 42491 // auditory receptor cell differentiation // inferred from // inferred from electronic annotation mutant phenotype 6810 // transport // inferred from electronic annotation /// 6811 // ion 4872 // receptor activity // inferred from electronic annotation /// 5216 // ion 16020 // membrane // inferred from electronic annotation /// 16021 // IPR001429 // ATP P2X transport // inferred from electronic annotation /// 6915 // apoptosis // channel activity // inferred from electronic annotation /// 5524 // ATP --- integral to membrane // traceable author statement receptor inferred from electronic annotation binding // inferred from electronic annotation 6350 // transcription // inferred from electronic annotation /// 6355 // 5634 // nucleus // inferred from direct assay /// 5667 // transcription factor 3677 // DNA binding // inferred from electronic annotation /// 3700 // IPR000910 // HMG1/2 regulation of transcription, DNA-dependent // inferred from electronic --- complex // inferred from electronic annotation transcription factor activity // inferred from electronic annotation (high mobility group) box annotation

IPR001478 // 7242 // intracellular signaling cascade // inferred from sequence or 5911 // intercellular junction // inferred from sequence or structural PDZ/DHR/GLGF domain ------structural similarity similarity /// IPR007597 // CheC- like protein

5515 // protein binding // inferred from physical interaction /// 30295 // 5634 // nucleus // inferred from sequence or structural similarity /// 5737 // 7049 // cell cycle // inferred from sequence or structural similarity protein kinase activator activity // inferred from sequence or structural ------cytoplasm // inferred from sequence or structural similarity similarity 6694 // steroid biosynthesis // inferred from electronic annotation /// 6695 // 4161 // dimethylallyltranstransferase activity // inferred from electronic cholesterol biosynthesis // inferred from electronic annotation /// 8299 // annotation /// 4337 // geranyltranstransferase activity // inferred from Cholesterol_Biosynthesis // IPR000092 // Polyprenyl isoprenoid biosynthesis // inferred from electronic annotation /// 8610 // --- electronic annotation /// 16740 // transferase activity // inferred from GenMAPP synthetase lipid biosynthesis // inferred from electronic annotation /// 16126 // sterol electronic annotation biosynthesis // inferred from electronic annotation

------

IPR007087 // Zn-finger, ------C2H2 type 4721 // phosphoprotein phosphatase activity // inferred from sequence or structural similarity /// 4725 // protein tyrosine phosphatase activity // 6470 // protein amino acid dephosphorylation // inferred from sequence or inferred from electronic annotation /// 8138 // protein 16020 // membrane // inferred from electronic annotation ------structural similarity tyrosine/serine/threonine phosphatase activity // inferred from sequence or structural similarity /// 16787 // hydrolase activity // inferred from electronic annotation IPR001936 // Ras GTPase-activating 7242 // intracellular signaling cascade // inferred from sequence or 5096 // GTPase activator activity // inferred from electronic annotation /// protein /// IPR000008 // ------structural similarity 46872 // metal ion binding // inferred from electronic annotation C2 domain /// IPR001849 // Pleckstrin- like

7017 // microtubule-based process // inferred from electronic annotation /// 5874 // microtubule // inferred from electronic annotation /// 5875 // 5519 // cytoskeletal regulatory protein binding // inferred from electronic IPR001084 // Tubulin- 7026 // negative regulation of microtubule depolymerization // inferred from --- microtubule associated complex // inferred from electronic annotation annotation binding Tau protein electronic annotation

3676 // nucleic acid binding // inferred from electronic annotation /// 3677 // DNA binding // inferred from electronic annotation /// 3729 // mRNA IPR000571 // Zn-finger, 6402 // mRNA catabolism // inferred from sequence or structural similarity 5634 // nucleus // inferred from electronic annotation --- binding // inferred from sequence or structural similarity /// 46872 // metal C-x8-C-x5-C-x3-H type ion binding // inferred from electronic annotation 5615 // extracellular space // traceable author statement /// 16020 // IPR004031 // PMP- 16049 // cell growth // inferred from sequence or structural similarity membrane // inferred from electronic annotation /// 16021 // integral to ------22/EMP/MP20 and membrane // traceable author statement claudin family 74 // regulation of cell cycle // inferred from electronic annotation /// 6355 // IPR000418 // Ets- regulation of transcription, DNA-dependent // inferred from electronic 5622 // intracellular // inferred from electronic annotation /// 5634 // nucleus 3677 // DNA binding // inferred from electronic annotation /// 3700 // Smooth_muscle_contracti domain /// IPR003118 // annotation /// 50875 // cellular physiological process // inferred from // inferred from electronic annotation transcription factor activity // inferred from electronic annotation on // GenMAPP Sterile alpha motif electronic annotation (SAM)/Pointed domain 6084 // acetyl-CoA metabolism // inferred from sequence or structural similarity /// 6355 // regulation of transcription, DNA-dependent // inferred 3677 // DNA binding // inferred from sequence or structural similarity /// from sequence or structural similarity /// 6694 // steroid biosynthesis // 5634 // nucleus // inferred from sequence or structural similarity /// 5667 // 3700 // transcription factor activity // inferred from sequence or structural inferred from electronic annotation /// 6695 // cholesterol biosynthesis // IPR008260 // transcription factor complex // inferred from sequence or structural similarity /// 4421 // hydroxymethylglutaryl-CoA synthase activity // inferred Cholesterol_Biosynthesis // inferred from sequence or structural similarity /// 6700 // C21-steroid Hydroxymethylglutaryl- similarity /// 5737 // cytoplasm // inferred from sequence or structural from sequence or structural similarity /// 16740 // transferase activity // GenMAPP hormone biosynthesis // inferred from sequence or structural similarity /// coenzyme A synthase similarity inferred from electronic annotation /// 16829 // lyase activity // inferred from 7548 // sex differentiation // inferred from sequence or structural similarity sequence or structural similarity /// 8610 // lipid biosynthesis // inferred from electronic annotation /// 16126 // sterol biosynthesis // inferred from electronic annotation

--- 5654 // nucleoplasm // inferred from direct assay ------

3835 // beta-galactoside alpha-2,6-sialyltransferase activity // inferred from 5794 // Golgi apparatus // inferred from electronic annotation /// 5795 // electronic annotation /// 8373 // sialyltransferase activity // inferred from 6486 // protein amino acid glycosylation // inferred from electronic Golgi stack // inferred from electronic annotation /// 16020 // membrane // N-Glycan biosynthesis // IPR001675 // Glycosyl direct assay /// 16740 // transferase activity // inferred from electronic annotation inferred from electronic annotation /// 16021 // integral to membrane // KEGG transferase, family 29 annotation /// 16757 // transferase activity, transferring glycosyl groups // traceable author statement inferred from electronic annotation

6955 // immune response // inferred from electronic annotation /// 19882 // antigen presentation // inferred from electronic annotation /// 19883 // antigen presentation, endogenous antigen // inferred from electronic 16021 // integral to membrane // inferred from electronic annotation /// IPR001039 // Major annotation /// 19885 // antigen processing, endogenous antigen via MHC 42612 // MHC class I protein complex // inferred from electronic annotation histocompatibility class I // inferred from electronic annotation /// 6952 // defense response // 30106 // MHC class I receptor activity // inferred from electronic annotation /// 9897 // external side of plasma membrane // inferred from direct assay complex protein, class I traceable author statement /// 6955 // immune response // inferred from /// 30106 // MHC class I receptor activity // inferred from sequence or mRNA_processing_bindin /// 16020 // membrane // inferred from sequence or structural similarity /// /// IPR007110 // sequence or structural similarity /// 19883 // antigen presentation, structural similarity /// 42605 // peptide antigen binding // inferred from g_Reactome // GenMAPP 16021 // integral to membrane // traceable author statement /// 5886 // Immunoglobulin-like /// endogenous antigen // inferred from sequence or structural similarity /// direct assay /// 42606 // endogenous peptide antigen binding // Unknown plasma membrane // inferred from electronic annotation /// 9986 // cell IPR010579 // MHC_I, C- 19885 // antigen processing, endogenous antigen via MHC class I // surface // inferred from direct assay terminal inferred from sequence or structural similarity /// 6952 // defense response // inferred from electronic annotation /// 48004 // antigen presentation, endogenous peptide antigen // Unknown

IPR001751 // Calcium- binding protein, S- 5615 // extracellular space // inferred from electronic annotation /// 5737 // 5125 // cytokine activity // inferred from electronic annotation /// 5509 // 7283 // spermatogenesis // inferred from mutant phenotype --- 100/ICaBP type /// cytoplasm // inferred from direct assay calcium ion binding // inferred from electronic annotation IPR002048 // Calcium- binding EF-hand 6350 // transcription // inferred from electronic annotation /// 6355 // regulation of transcription, DNA-dependent // inferred from electronic 3676 // nucleic acid binding // inferred from electronic annotation /// 3677 // annotation /// 30282 // bone mineralization // inferred from mutant DNA binding // inferred from electronic annotation /// 8270 // zinc ion IPR007087 // Zn-finger, 5634 // nucleus // inferred from electronic annotation --- phenotype /// 45449 // regulation of transcription // inferred from mutant binding // inferred from electronic annotation /// 46872 // metal ion binding C2H2 type phenotype /// 45672 // positive regulation of osteoclast differentiation // // inferred from electronic annotation inferred from mutant phenotype 7165 // signal transduction // inferred from electronic annotation /// 7600 // Calcium_regulation_in_car sensory perception // inferred from electronic annotation /// 8277 // diac_cells // GenMAPP /// 5622 // intracellular // inferred from direct assay 5515 // protein binding // inferred from physical interaction --- regulation of G-protein coupled receptor protein signaling pathway // Smooth_muscle_contracti inferred from mutant phenotype on // GenMAPP

IPR001375 // Peptidase 3824 // catalytic activity // inferred from electronic annotation /// 4252 // S9, prolyl oligopeptidase serine-type endopeptidase activity // inferred from electronic annotation /// active site region /// 6508 // proteolysis and peptidolysis // inferred from electronic annotation /// 4287 // prolyl oligopeptidase activity // inferred from sequence or structural 5634 // nucleus // inferred from direct assay /// 5737 // cytoplasm // inferred IPR004106 // Peptidase 19538 // protein metabolism // inferred from sequence or structural similarity /// 8233 // peptidase activity // inferred from electronic annotation --- from direct assay S9A, prolyl similarity /// 8236 // serine-type peptidase activity // inferred from electronic oligopeptidase, N- annotation /// 16787 // hydrolase activity // inferred from electronic terminal beta-propeller annotation domain

IPR001841 // Zn-finger, --- 16021 // integral to membrane // traceable author statement 46872 // metal ion binding // inferred from electronic annotation --- RING 5615 // extracellular space // traceable author statement /// 5887 // integral 4872 // receptor activity // inferred from electronic annotation /// 4896 // 6955 // immune response // inferred from electronic annotation /// 7166 // to plasma membrane // inferred from electronic annotation /// 16020 // hematopoietin/interferon-class (D200-domain) cytokine receptor activity // Inflammatory_Response_P cell surface receptor linked signal transduction // inferred from electronic --- membrane // inferred from electronic annotation /// 16021 // integral to inferred from electronic annotation /// 4907 // interleukin receptor activity // athway // GenMAPP annotation membrane // inferred from electronic annotation inferred from electronic annotation 1756 // somitogenesis // inferred from mutant phenotype /// 6350 // transcription // inferred from electronic annotation /// 6355 // regulation of transcription, DNA-dependent // inferred from electronic annotation /// 6357 // regulation of transcription from RNA polymerase II promoter // 3677 // DNA binding // inferred from direct assay /// 3700 // transcription 5634 // nucleus // inferred from direct assay /// 5667 // transcription factor inferred from direct assay /// 16055 // Wnt receptor signaling pathway // factor activity // inferred from direct assay /// 3705 // RNA polymerase II TGF_Beta_Signaling_Path IPR000910 // HMG1/2 complex // inferred from physical interaction /// 5737 // cytoplasm // inferred inferred from electronic annotation /// 42475 // odontogenesis (sensu transcription factor activity, enhancer binding // inferred from genetic way // GenMAPP (high mobility group) box from direct assay Vertebrata) // inferred from mutant phenotype /// 45944 // positive interaction /// 5515 // protein binding // inferred from physical interaction regulation of transcription from RNA polymerase II promoter // inferred from direct assay /// 48468 // cell development // inferred from genetic interaction ------IPR001202 // WW/Rsp5/WWP 6464 // protein modification // inferred from sequence or structural 4842 // ubiquitin-protein ligase activity // inferred from sequence or domain /// IPR000569 // similarity /// 6512 // ubiquitin cycle // inferred from sequence or structural 5622 // intracellular // inferred from sequence or structural similarity structural similarity /// 16874 // ligase activity // inferred from electronic --- HECT domain (Ubiquitin- similarity annotation protein ligase) /// IPR000008 // C2 domain 3779 // actin binding // inferred from direct assay /// 5515 // protein binding IPR001452 // SH3 /// 910 // cytokinesis // Unknown /// 6897 // endocytosis // inferred from 1725 // stress fiber // inferred from direct assay /// 5826 // contractile ring // // inferred from physical interaction /// 19903 // protein phosphatase --- IPR001060 // electronic annotation inferred from direct assay binding // inferred from direct assay Cdc15/Fes/CIP4 IPR001606 // ARID (AT- --- 5622 // intracellular // inferred from sequence or structural similarity 3677 // DNA binding // inferred from sequence or structural similarity --- rich interaction domain) protein 59 // protein-nucleus import, docking // inferred from electronic annotation 5634 // nucleus // inferred from electronic annotation /// 5643 // nuclear /// 6810 // transport // inferred from electronic annotation /// 15031 // protein pore // inferred from electronic annotation /// 5737 // cytoplasm // inferred 8565 // protein transporter activity // inferred from electronic annotation ------transport // inferred from electronic annotation from electronic annotation 166 // nucleotide binding // inferred from electronic annotation /// 4672 // protein kinase activity // inferred from sequence or structural similarity /// 4674 // protein serine/threonine kinase activity // inferred from electronic annotation /// 4703 // G-protein coupled receptor kinase activity // inferred from direct assay /// 4703 // G-protein coupled receptor kinase activity // IPR000719 // Protein 6468 // protein amino acid phosphorylation // inferred from sequence or inferred from sequence or structural similarity /// 4713 // protein-tyrosine kinase /// IPR001849 // structural similarity /// 7165 // signal transduction // inferred from sequence --- kinase activity // inferred from sequence or structural similarity /// 4871 // --- Pleckstrin-like /// or structural similarity signal transducer activity // inferred from sequence or structural similarity IPR000342 // Regulator /// 4872 // receptor activity // inferred from electronic annotation /// 5524 // of G protein ATP binding // inferred from electronic annotation /// 16301 // kinase activity // inferred from electronic annotation /// 16740 // transferase activity // inferred from electronic annotation /// 47696 // beta-adrenergic-receptor kinase activity // inferred from electronic annotation

6810 // transport // inferred from electronic annotation /// 6811 // ion transport // inferred from electronic annotation /// 6813 // potassium ion 5215 // transporter activity // inferred from electronic annotation /// 5279 // transport // inferred from electronic annotation /// 6814 // sodium ion 5887 // integral to plasma membrane // inferred from electronic annotation amino acid-polyamine transporter activity // inferred from electronic IPR004841 // Amino transport // inferred from electronic annotation /// 6821 // chloride transport /// 16020 // membrane // inferred from electronic annotation /// 16021 // annotation /// 5386 // carrier activity // inferred from electronic annotation /// --- acid permease- // inferred from electronic annotation /// 6865 // amino acid transport // integral to membrane // traceable author statement 15293 // symporter activity // inferred from electronic annotation /// 15377 // associated region inferred from electronic annotation /// 7605 // perception of sound // cation:chloride symporter activity // inferred from electronic annotation inferred from electronic annotation 8378 // galactosyltransferase activity // inferred from sequence or structural similarity /// 8499 // UDP-galactose beta-N-acetylglucosamine Keratan sulfate 6486 // protein amino acid glycosylation // inferred from mutant phenotype 5795 // Golgi stack // inferred from electronic annotation /// 16020 // beta-1,3-galactosyltransferase activity // inferred from sequence or biosynthesis // KEGG /// /// 6486 // protein amino acid glycosylation // inferred from sequence or IPR002659 // Glycosyl membrane // inferred from sequence or structural similarity /// 16021 // structural similarity /// 16740 // transferase activity // inferred from Blood group glycolipid structural similarity /// 7411 // axon guidance // inferred from mutant transferase, family 31 integral to membrane // inferred from electronic annotation electronic annotation /// 16757 // transferase activity, transferring glycosyl biosynthesis- phenotype /// 7608 // perception of smell // inferred from mutant phenotype groups // inferred from electronic annotation /// 30145 // manganese ion neolactoseries // KEGG binding // inferred from electronic annotation 3755 // peptidyl-prolyl cis-trans isomerase activity // inferred from electronic annotation /// 5524 // ATP binding // inferred from sequence or structural IPR001179 // 6457 // protein folding // inferred from electronic annotation /// 6810 // similarity /// 5528 // FK506 binding // inferred from sequence or structural TGF_Beta_Signaling_Path 16020 // membrane // inferred from sequence or structural similarity Peptidylprolyl transport // inferred from sequence or structural similarity similarity /// 16853 // isomerase activity // inferred from electronic way // GenMAPP isomerase, FKBP-type annotation /// 42626 // ATPase activity, coupled to transmembrane movement of substances // inferred from sequence or structural similarity

250 // lanosterol synthase activity // inferred from electronic annotation /// 6694 // steroid biosynthesis // inferred from electronic annotation /// 8152 // Cholesterol_Biosynthesis // IPR001330 // 3824 // catalytic activity // inferred from electronic annotation /// 16829 // metabolism // inferred from electronic annotation /// 8610 // lipid --- GenMAPP /// Biosynthesis Prenyltransferase/squal lyase activity // inferred from electronic annotation /// 16853 // isomerase biosynthesis // inferred from electronic annotation of steroids // KEGG ene oxidase activity // inferred from electronic annotation

3824 // catalytic activity // inferred from sequence or structural similarity /// 6725 // aromatic compound metabolism // inferred from sequence or IPR000073 // Alpha/beta --- 4301 // epoxide hydrolase activity // inferred from electronic annotation /// --- structural similarity hydrolase fold 16787 // hydrolase activity // inferred from electronic annotation ------5515 // protein binding // inferred from physical interaction /// 8270 // zinc 30036 // actin cytoskeleton organization and biogenesis // traceable author 5634 // nucleus // inferred from sequence or structural similarity /// 15629 // IPR001781 // Zn-binding ion binding // inferred from sequence or structural similarity /// 46872 // --- statement actin cytoskeleton // traceable author statement protein, LIM metal ion binding // inferred from electronic annotation 6955 // immune response // inferred from electronic annotation /// 19882 // antigen presentation // inferred from direct assay /// 19884 // antigen presentation, exogenous antigen // inferred from electronic annotation /// 5764 // lysosome // inferred from direct assay /// 5886 // plasma membrane IPR001003 // MHC 19886 // antigen processing, exogenous antigen via MHC class II // // inferred from direct assay /// 9897 // external side of plasma membrane // 5515 // protein binding // inferred from physical interaction /// 42605 // Class II alpha chain, inferred from electronic annotation /// 42591 // antigen presentation, inferred from direct assay /// 16020 // membrane // inferred from electronic peptide antigen binding // inferred from direct assay /// 45012 // MHC class --- alpha-1 domain /// exogenous antigen via MHC class II // inferred from direct assay /// 45582 annotation /// 16021 // integral to membrane // traceable author statement II receptor activity // inferred from direct assay IPR007110 // // positive regulation of T cell differentiation // inferred from direct assay /// /// 42613 // MHC class II protein complex // inferred from direct assay Immunoglobulin-like 48002 // antigen presentation, peptide antigen // inferred from direct assay /// 48005 // antigen presentation, exogenous peptide antigen // inferred from direct assay

5634 // nucleus // inferred from direct assay /// 5634 // nucleus // traceable IPR001810 // Cyclin-like 6512 // ubiquitin cycle // inferred from electronic annotation /// 7219 // 3700 // transcription factor activity // inferred from direct assay /// 5515 // author statement /// 5737 // cytoplasm // traceable author statement /// F-box /// IPR001680 // G- Notch signaling pathway // inferred from direct assay /// 16567 // protein protein binding // inferred from physical interaction /// 5515 // protein --- 5783 // endoplasmic reticulum // inferred from direct assay /// 5794 // Golgi protein beta WD-40 ubiquitination // inferred from sequence or structural similarity binding // inferred from sequence or structural similarity apparatus // inferred from direct assay repeat 6333 // chromatin assembly or disassembly // inferred from electronic annotation /// 6350 // transcription // inferred from electronic annotation /// 785 // chromatin // inferred from electronic annotation /// 5634 // nucleus // 6355 // regulation of transcription, DNA-dependent // inferred from 3682 // chromatin binding // inferred from electronic annotation --- IPR000953 // Chromo inferred from electronic annotation electronic annotation /// 16568 // chromatin modification // inferred from electronic annotation 3779 // actin binding // inferred from electronic annotation /// 5515 // protein IPR000900 // Nebulin /// 5737 // cytoplasm // inferred from direct assay /// 5856 // cytoskeleton // binding // inferred from physical interaction /// 8270 // zinc ion binding // 6810 // transport // inferred from electronic annotation /// 6811 // ion IPR001781 // Zn-binding inferred from electronic annotation /// 5925 // focal adhesion // inferred inferred from electronic annotation /// 46872 // metal ion binding // inferred --- transport // inferred from electronic annotation protein, LIM /// from direct assay from electronic annotation /// 51015 // actin filament binding // inferred from IPR001452 // SH3 direct assay IPR003961 // 5615 // extracellular space // traceable author statement /// 16020 // 4872 // receptor activity // inferred from electronic annotation /// 4896 // 7165 // signal transduction // inferred from direct assay /// 8593 // Fibronectin, type III /// membrane // inferred from electronic annotation /// 16021 // integral to hematopoietin/interferon-class (D200-domain) cytokine receptor activity // --- regulation of Notch signaling pathway // inferred from direct assay IPR010457 // Ig-like C2- membrane // traceable author statement inferred from electronic annotation type 5096 // GTPase activator activity // inferred from sequence or structural 7165 // signal transduction // inferred from sequence or structural similarity ------IPR003109 // GoLoco similarity

IPR003008 // 5200 // structural constituent of cytoskeleton // inferred from electronic Tubulin/FtsZ, GTPase /// 7017 // microtubule-based process // inferred from electronic annotation 5874 // microtubule // inferred from electronic annotation --- annotation /// 5525 // GTP binding // inferred from electronic annotation IPR008280 // Tubulin/FtsZ, C-terminal

IPR001849 // Pleckstrin------like

Krebs-TCA_Cycle // GenMAPP /// Citrate cycle 6092 // main pathways of carbohydrate metabolism // inferred from 4450 // isocitrate dehydrogenase (NADP+) activity // inferred from (TCA cycle) // KEGG /// IPR001804 // electronic annotation /// 6097 // glyoxylate cycle // inferred from electronic 5739 // mitochondrion // inferred from direct assay /// 5739 // mitochondrion electronic annotation /// 16491 // oxidoreductase activity // inferred from Glutathione metabolism // Isocitrate/isopropylmalat annotation /// 6099 // tricarboxylic acid cycle // inferred from electronic // inferred from electronic annotation electronic annotation KEGG /// Reductive e dehydrogenase annotation /// 8152 // metabolism // inferred from electronic annotation carboxylate cycle (CO2 fixation) // KEGG

6350 // transcription // inferred from electronic annotation /// 6355 // 118 // histone deacetylase complex // inferred from physical interaction /// regulation of transcription, DNA-dependent // inferred from electronic 4407 // histone deacetylase activity // inferred from electronic annotation /// 792 // heterochromatin // inferred from direct assay /// 5634 // nucleus // Cell_Cycle_KEGG // IPR000286 // Histone annotation /// 7492 // endoderm development // inferred from direct assay 5515 // protein binding // inferred from physical interaction /// 16787 // inferred from electronic annotation /// 16581 // NuRD complex // inferred GenMAPP deacetylase superfamily /// 7492 // endoderm development // inferred from mutant phenotype /// hydrolase activity // inferred from electronic annotation from physical interaction 16568 // chromatin modification // inferred from electronic annotation 4872 // receptor activity // inferred from electronic annotation /// 46872 // IPR001841 // Zn-finger, ------metal ion binding // inferred from electronic annotation RING

IPR007863 // Peptidase 4240 // mitochondrial processing peptidase activity // inferred from M16, C-terminal /// ------electronic annotation IPR001431 // Peptidase M16, insulinase-like IPR002101 // 3779 // actin binding // inferred from electronic annotation /// 5516 // Myristoylated alanine- --- 16020 // membrane // inferred from direct assay --- binding // inferred from electronic annotation rich C-kinase substrate MARCKS IPR001039 // Major histocompatibility ------complex protein, class I /// IPR007110 // Immunoglobulin-like 4616 // phosphogluconate dehydrogenase (decarboxylating) activity // 6098 // pentose-phosphate shunt // inferred from sequence or structural inferred from sequence or structural similarity /// 8442 // 3- 5739 // mitochondrion // inferred from direct assay /// 5739 // mitochondrion similarity /// 6573 // valine metabolism // inferred from sequence or hydroxyisobutyrate dehydrogenase activity // inferred from sequence or ------// inferred from sequence or structural similarity structural similarity structural similarity /// 16491 // oxidoreductase activity // inferred from sequence or structural similarity 122 // negative regulation of transcription from RNA polymerase II 3714 // transcription corepressor activity // inferred from direct assay /// promoter // inferred from direct assay /// 6350 // transcription // inferred 4407 // histone deacetylase activity // inferred from direct assay /// 5515 // 5634 // nucleus // inferred from direct assay /// 5737 // cytoplasm // inferred Cell_Cycle_KEGG // IPR000286 // Histone from electronic annotation /// 6355 // regulation of transcription, DNA- protein binding // inferred from physical interaction /// 16564 // from direct assay GenMAPP deacetylase superfamily dependent // inferred from electronic annotation /// 16568 // chromatin transcriptional repressor activity // inferred from direct assay /// 16787 // modification // inferred from electronic annotation hydrolase activity // inferred from electronic annotation IPR001664 // 5634 // nucleus // inferred from direct assay /// 5638 // lamin filament // Intermediate filament 6998 // nuclear membrane organization and biogenesis // inferred from 5198 // structural molecule activity // inferred from electronic annotation /// inferred from direct assay /// 5882 // intermediate filament // inferred from --- protein /// IPR001322 // genetic interaction 5515 // protein binding // inferred from physical interaction electronic annotation Intermediate filament, C- terminal

--- 5615 // extracellular space // traceable author statement ------

IPR005834 // Haloacid ------16787 // hydrolase activity // inferred from electronic annotation --- dehalogenase-like hydrolase IPR007651 // Lipin, N- 6629 // lipid metabolism // inferred from mutant phenotype /// 45598 // 5634 // nucleus // inferred from direct assay ------terminal conserved regulation of fat cell differentiation // inferred from mutant phenotype region 6915 // apoptosis // inferred from direct assay /// 6916 // anti-apoptosis // Apoptosis // GenMAPP /// IPR000712 // Apoptosis inferred from direct assay /// 9314 // response to radiation // inferred from 5739 // mitochondrion // inferred from direct assay /// 16020 // membrane // Apoptosis_GenMAPP // regulator Bcl-2 protein, mutant phenotype /// 42981 // regulation of apoptosis // inferred from 5515 // protein binding // inferred from physical interaction /// 5515 // inferred from electronic annotation /// 16021 // integral to membrane // GenMAPP /// BH /// IPR003093 // electronic annotation /// 43066 // negative regulation of apoptosis // protein binding // inferred from sequence or structural similarity inferred from electronic annotation Apoptosis_KEGG // Apoptosis regulator Bcl- inferred from mutant phenotype /// 45768 // positive regulation of anti- GenMAPP 2 protein, BH4 apoptosis // inferred from direct assay 166 // nucleotide binding // inferred from electronic annotation /// 287 // magnesium ion binding // inferred from electronic annotation /// 4672 // protein kinase activity // inferred from electronic annotation /// 4674 // protein serine/threonine kinase activity // inferred from electronic IPR001772 // Kinase- 6468 // protein amino acid phosphorylation // inferred from electronic annotation /// 4713 // protein-tyrosine kinase activity // inferred from associated, C-terminal /// annotation /// 7275 // development // inferred from electronic annotation /// 16020 // membrane // inferred from electronic annotation --- sequence or structural similarity /// 5524 // ATP binding // inferred from IPR000719 // Protein 30154 // cell differentiation // inferred from electronic annotation electronic annotation /// 16301 // kinase activity // inferred from electronic kinase annotation /// 16740 // transferase activity // inferred from electronic annotation /// 46872 // metal ion binding // inferred from electronic annotation IPR001841 // Zn-finger, ------46872 // metal ion binding // inferred from electronic annotation --- RING

166 // nucleotide binding // inferred from electronic annotation /// 3824 // IPR000728 // AIR catalytic activity // inferred from electronic annotation /// 4756 // selenide, synthase related protein ------water dikinase activity // inferred from electronic annotation /// 5524 // ATP --- /// IPR010918 // AIR binding // inferred from electronic annotation /// 16740 // transferase synthase related protein, activity // inferred from electronic annotation C-terminal IPR006164 // Ku /// IPR003034 // DNA- 6281 // DNA repair // inferred from electronic annotation /// 6302 // double- 166 // nucleotide binding // inferred from electronic annotation /// 3677 // binding SAP /// strand break repair // inferred from mutant phenotype /// 6303 // double- DNA binding // inferred from electronic annotation /// 4003 // ATP- IPR005161 // strand break repair via nonhomologous end-joining // inferred from mutant 5634 // nucleus // inferred from direct assay /// 5737 // cytoplasm // inferred dependent DNA helicase activity // inferred from electronic annotation /// --- Ku70/Ku80 N-terminal phenotype /// 6310 // DNA recombination // inferred from electronic from direct assay 4386 // helicase activity // inferred from electronic annotation /// 5524 // alpha/beta domain /// annotation /// 6974 // response to DNA damage stimulus // inferred from ATP binding // inferred from electronic annotation /// 16787 // hydrolase IPR005160 // electronic annotation activity // inferred from electronic annotation Ku70/Ku80 C-terminal arm IPR000007 // Tubby /// 7242 // intracellular signaling cascade // inferred from electronic annotation 5737 // cytoplasm // inferred from sequence or structural similarity ------IPR001680 // G-protein beta WD-40 repeat 5624 // membrane fraction // inferred from direct assay /// 5739 // 6665 // sphingolipid metabolism // inferred from direct assay /// 6668 // mitochondrion // inferred from direct assay /// 5783 // endoplasmic IPR000326 // PA- sphinganine-1-phosphate metabolism // inferred from direct assay /// 6670 16787 // hydrolase activity // inferred from electronic annotation /// 42392 // reticulum // inferred from direct assay /// 5794 // Golgi apparatus // inferred --- phosphatase related // sphingosine metabolism // inferred from direct assay /// 6915 // apoptosis sphingosine-1-phosphate phosphatase activity // inferred from direct assay from direct assay /// 15629 // actin cytoskeleton // inferred from direct phosphoesterase // inferred from direct assay assay /// 16021 // integral to membrane // traceable author statement

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6464 // protein modification // inferred from electronic annotation /// 6950 // 5783 // endoplasmic reticulum // inferred from electronic annotation /// Circadian_Exercise // response to stress // inferred from direct assay /// 6986 // response to 5789 // endoplasmic reticulum membrane // inferred from direct assay /// --- IPR000626 // Ubiquitin GenMAPP unfolded protein // inferred from direct assay 16021 // integral to membrane // inferred from direct assay

166 // nucleotide binding // inferred from electronic annotation /// 4672 // protein kinase activity // inferred from electronic annotation /// 4713 // 6468 // protein amino acid phosphorylation // inferred from electronic protein-tyrosine kinase activity // inferred from direct assay /// 4718 // annotation /// 7242 // intracellular signaling cascade // inferred from Janus kinase activity // inferred from electronic annotation /// 5515 // TGF_Beta_Signaling_Path IPR000719 // Protein 5856 // cytoskeleton // inferred from electronic annotation electronic annotation /// 18108 // peptidyl-tyrosine phosphorylation // protein binding // inferred from physical interaction /// 5524 // ATP binding // way // GenMAPP kinase inferred from direct assay inferred from electronic annotation /// 16301 // kinase activity // inferred from electronic annotation /// 16740 // transferase activity // inferred from electronic annotation

3824 // catalytic activity // inferred from electronic annotation /// 4615 // 8152 // metabolism // inferred from electronic annotation /// 19307 // Fructose and mannose IPR005002 // Eukaryotic 5737 // cytoplasm // inferred from electronic annotation phosphomannomutase activity // inferred from electronic annotation /// mannose biosynthesis // inferred from electronic annotation metabolism // KEGG phosphomannomutase 16853 // isomerase activity // inferred from electronic annotation

4721 // phosphoprotein phosphatase activity // inferred from electronic IPR001763 // annotation /// 4725 // protein tyrosine phosphatase activity // inferred from Rhodanese-like /// 6470 // protein amino acid dephosphorylation // inferred from electronic electronic annotation /// 8138 // protein tyrosine/serine/threonine 5634 // nucleus // inferred from electronic annotation --- IPR000340 // Dual annotation phosphatase activity // inferred from electronic annotation /// 16787 // specificity protein hydrolase activity // inferred from electronic annotation /// 17017 // MAP phosphatase kinase phosphatase activity // inferred from electronic annotation

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IPR008580 // Eukaryotic ------protein of unknown function DUF862 ------IPR002641 // Patatin

5615 // extracellular space // traceable author statement /// 5886 // plasma membrane // inferred from electronic annotation /// 16020 // membrane // IPR007110 // 6955 // immune response // inferred from electronic annotation ------inferred from electronic annotation /// 16021 // integral to membrane // Immunoglobulin-like traceable author statement IPR006674 // Metal- dependent 3824 // catalytic activity // inferred from electronic annotation /// 4114 // 3',5' 6955 // immune response // inferred from electronic annotation /// 7165 // phosphohydrolase, HD --- cyclic-nucleotide phosphodiesterase activity // inferred from electronic --- signal transduction // inferred from electronic annotation subdomain /// annotation IPR001660 // Sterile alpha motif SAM IPR008580 // Eukaryotic ------protein of unknown function DUF862

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IPR010533 // Vertebrate 6355 // regulation of transcription, DNA-dependent // inferred from 5634 // nucleus // inferred from electronic annotation 3677 // DNA binding // inferred from electronic annotation --- interleukin-3 regulated sequence or structural similarity transcription factor

------IPR007174 // Las1-like

3677 // DNA binding // inferred from electronic annotation /// 3700 // transcription factor activity // inferred from electronic annotation /// 3707 // IPR000536 // Ligand- steroid hormone receptor activity // inferred from electronic annotation /// binding domain of 4872 // receptor activity // inferred from electronic annotation /// 4879 // Apoptosis_KEGG // nuclear hormone 6350 // transcription // inferred from electronic annotation /// 6355 // ligand-dependent nuclear receptor activity // inferred from sequence or GenMAPP /// receptor /// IPR001409 // regulation of transcription, DNA-dependent // inferred from electronic 5634 // nucleus // inferred from direct assay structural similarity /// 4883 // glucocorticoid receptor activity // inferred Nuclear_Receptors // Glucocorticoid receptor annotation from electronic annotation /// 5496 // steroid binding // inferred from GenMAPP /// IPR001628 // Zn- electronic annotation /// 5515 // protein binding // inferred from physical finger, C4-type steroid interaction /// 46872 // metal ion binding // inferred from electronic receptor annotation 3677 // DNA binding // inferred from electronic annotation /// 5515 // protein binding // inferred from physical interaction /// 8233 // peptidase activity // IPR003323 // Ovarian inferred from electronic annotation /// 8234 // cysteine-type peptidase 6512 // ubiquitin cycle // inferred from electronic annotation /// 6915 // 5634 // nucleus // inferred from electronic annotation /// 5737 // cytoplasm tumour, otubain /// activity // inferred from electronic annotation /// 8270 // zinc ion binding // --- apoptosis // inferred from electronic annotation // inferred from direct assay IPR002653 // Zn-finger, inferred from electronic annotation /// 16787 // hydrolase activity // inferred A20-like from electronic annotation /// 46872 // metal ion binding // inferred from electronic annotation IPR001214 // Nuclear ------protein SET ------166 // nucleotide binding // inferred from electronic annotation /// 3774 // motor activity // inferred from electronic annotation /// 5198 // structural 5625 // soluble fraction // inferred from direct assay /// 5829 // cytosol // molecule activity // inferred from electronic annotation /// 5200 // structural Smooth_muscle_contracti IPR004000 // Actin/actin- --- inferred from direct assay /// 5856 // cytoskeleton // inferred from electronic constituent of cytoskeleton // inferred from electronic annotation /// 5515 // on // GenMAPP like annotation /// 5884 // actin filament // inferred from electronic annotation protein binding // inferred from electronic annotation /// 5524 // ATP binding // inferred from electronic annotation 8743 // L-threonine 3-dehydrogenase activity // inferred from electronic Glycine, serine and ------annotation /// 16491 // oxidoreductase activity // inferred from electronic threonine metabolism // --- annotation KEGG IPR004313 // ------Acireductone dioxygenase, ARD

4857 // enzyme inhibitor activity // inferred from direct assay /// 5515 // 6979 // response to oxidative stress // inferred from direct assay 5737 // cytoplasm // inferred from direct assay --- IPR000698 // Arrestin protein binding // inferred from physical interaction

6350 // transcription // inferred from electronic annotation /// 6355 // regulation of transcription, DNA-dependent // inferred from electronic annotation /// 6357 // regulation of transcription from RNA polymerase II promoter // inferred from direct assay /// 6955 // immune response // 5634 // nucleus // inferred from electronic annotation /// 5654 // 3712 // transcription cofactor activity // inferred from genetic interaction /// IPR004020 // Pyrin inferred from electronic annotation /// 42771 // DNA damage response, nucleoplasm // inferred from sequence or structural similarity /// 5730 // 5515 // protein binding // inferred from physical interaction /// 5515 // --- domain /// IPR004021 // signal transduction by p53 class mediator resulting in induction of nucleolus // inferred from sequence or structural similarity protein binding // inferred from sequence or structural similarity HIN-200/IF120x domain apoptosis // inferred from sequence or structural similarity /// 45669 // positive regulation of osteoblast differentiation // inferred from genetic interaction 5737 // cytoplasm // inferred from direct assay /// 16020 // membrane // 6813 // potassium ion transport // inferred from electronic annotation /// 5391 // sodium:potassium-exchanging ATPase activity // inferred from Calcium_regulation_in_car IPR000402 // Na+/K+ inferred from electronic annotation /// 16021 // integral to membrane // 6814 // sodium ion transport // inferred from electronic annotation electronic annotation diac_cells // GenMAPP ATPase, beta subunit traceable author statement 6350 // transcription // inferred from electronic annotation /// 6355 // regulation of transcription, DNA-dependent // inferred from electronic annotation /// 6357 // regulation of transcription from RNA polymerase II promoter // inferred from direct assay /// 6955 // immune response // 5634 // nucleus // inferred from electronic annotation /// 5654 // 3712 // transcription cofactor activity // inferred from genetic interaction /// IPR004020 // Pyrin inferred from electronic annotation /// 42771 // DNA damage response, nucleoplasm // inferred from sequence or structural similarity /// 5730 // 5515 // protein binding // inferred from physical interaction /// 5515 // --- domain /// IPR004021 // signal transduction by p53 class mediator resulting in induction of nucleolus // inferred from sequence or structural similarity protein binding // inferred from sequence or structural similarity HIN-200/IF120x domain apoptosis // inferred from sequence or structural similarity /// 45669 // positive regulation of osteoblast differentiation // inferred from genetic interaction 4437 // inositol or phosphatidylinositol phosphatase activity // inferred from 6470 // protein amino acid dephosphorylation // inferred from electronic electronic annotation /// 4721 // phosphoprotein phosphatase activity // IPR010569 // annotation /// 46839 // phospholipid dephosphorylation // inferred from --- inferred from electronic annotation /// 5515 // protein binding // inferred --- Myotubularin-related electronic annotation from physical interaction /// 30234 // enzyme regulator activity // inferred from direct assay IPR007087 // Zn-finger, 3676 // nucleic acid binding // inferred from electronic annotation /// 5515 // ------C2H2 type /// protein binding // inferred from physical interaction IPR001909 // KRAB box

5078 // MAP-kinase scaffold activity // inferred from direct assay /// 5515 // IPR001452 // SH3 /// G13_Signaling_Pathway // 46328 // regulation of JNK cascade // inferred from direct assay 30027 // lamellipodium // inferred from direct assay protein binding // inferred from physical interaction /// 46872 // metal ion IPR001841 // Zn-finger, GenMAPP binding // inferred from electronic annotation RING 8076 // voltage-gated potassium channel complex // inferred from 5249 // voltage-gated potassium channel activity // inferred from electronic 6813 // potassium ion transport // inferred from electronic annotation electronic annotation /// 16020 // membrane // inferred from electronic ------annotation /// 5515 // protein binding // inferred from electronic annotation annotation 3676 // nucleic acid binding // inferred from electronic annotation /// 3677 // 6350 // transcription // inferred from electronic annotation /// 6355 // IPR007087 // Zn-finger, 5622 // intracellular // inferred from electronic annotation /// 5634 // nucleus DNA binding // inferred from electronic annotation /// 8270 // zinc ion regulation of transcription, DNA-dependent // inferred from electronic --- C2H2 type /// // inferred from electronic annotation binding // inferred from electronic annotation /// 46872 // metal ion binding annotation IPR001909 // KRAB box // inferred from electronic annotation 4872 // receptor activity // inferred from electronic annotation /// 4896 // 7166 // cell surface receptor linked signal transduction // inferred from 9897 // external side of plasma membrane // inferred from direct assay /// hematopoietin/interferon-class (D200-domain) cytokine receptor activity // IPR003961 // electronic annotation /// 48535 // lymph node development // inferred from 16020 // membrane // inferred from electronic annotation /// 16021 // --- inferred from electronic annotation /// 4907 // interleukin receptor activity // Fibronectin, type III mutant phenotype integral to membrane // traceable author statement inferred from electronic annotation 3676 // nucleic acid binding // inferred from electronic annotation /// 3677 // 6350 // transcription // inferred from electronic annotation /// 6355 // IPR007087 // Zn-finger, 5622 // intracellular // inferred from electronic annotation /// 5634 // nucleus DNA binding // inferred from electronic annotation /// 8270 // zinc ion regulation of transcription, DNA-dependent // inferred from electronic --- C2H2 type /// // inferred from electronic annotation binding // inferred from electronic annotation /// 46872 // metal ion binding annotation IPR001909 // KRAB box // inferred from electronic annotation 6915 // apoptosis // inferred from sequence or structural similarity /// 42981 // regulation of apoptosis // inferred from sequence or structural similarity IPR009616 // Bim, N- 16020 // membrane // inferred from electronic annotation --- Apoptosis // GenMAPP /// 43065 // positive regulation of apoptosis // inferred from electronic terminal annotation IPR007110 // 6968 // cellular defense response // inferred from electronic annotation 5887 // integral to plasma membrane // inferred from electronic annotation ------Immunoglobulin-like 166 // nucleotide binding // inferred from electronic annotation /// 3774 // motor activity // inferred from electronic annotation /// 5198 // structural 5625 // soluble fraction // inferred from direct assay /// 5829 // cytosol // molecule activity // inferred from electronic annotation /// 5200 // structural Smooth_muscle_contracti IPR004000 // Actin/actin- --- inferred from direct assay /// 5856 // cytoskeleton // inferred from electronic constituent of cytoskeleton // inferred from electronic annotation /// 5515 // on // GenMAPP like annotation /// 5884 // actin filament // inferred from electronic annotation protein binding // inferred from electronic annotation /// 5524 // ATP binding // inferred from electronic annotation

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6810 // transport // inferred from electronic annotation /// 6812 // cation 16020 // membrane // inferred from electronic annotation /// 16021 // IPR002524 // Cation transport // inferred from electronic annotation /// 6829 // zinc ion transport 8324 // cation transporter activity // inferred from electronic annotation --- integral to membrane // traceable author statement efflux protein // inferred from electronic annotation 1843 // neural tube closure // inferred from mutant phenotype /// 6350 // 5515 // protein binding // inferred from physical interaction /// 8134 // transcription // inferred from electronic annotation /// 6355 // regulation of transcription factor binding // inferred from direct assay /// 8270 // zinc ion IPR001781 // Zn-binding transcription, DNA-dependent // inferred from electronic annotation /// 5667 // transcription factor complex // inferred from direct assay --- binding // inferred from electronic annotation /// 46872 // metal ion binding protein, LIM 6366 // transcription from RNA polymerase II promoter // inferred from // inferred from electronic annotation direct assay IPR002085 // Zinc- 4024 // alcohol dehydrogenase activity, zinc-dependent // inferred from containing alcohol ------sequence or structural similarity /// 8270 // zinc ion binding // inferred from --- dehydrogenase sequence or structural similarity superfamily

4437 // inositol or phosphatidylinositol phosphatase activity // inferred from 6470 // protein amino acid dephosphorylation // inferred from electronic electronic annotation /// 4438 // phosphatidylinositol-3-phosphatase activity IPR004182 // GRAM 5737 // cytoplasm // inferred from direct assay /// 5886 // plasma annotation /// 46839 // phospholipid dephosphorylation // inferred from // inferred from direct assay /// 4721 // phosphoprotein phosphatase --- domain /// IPR010569 // membrane // inferred from direct assay electronic annotation activity // inferred from electronic annotation /// 16787 // hydrolase activity // Myotubularin-related inferred from electronic annotation

6915 // apoptosis // inferred from sequence or structural similarity /// 42981 // regulation of apoptosis // inferred from sequence or structural similarity IPR009616 // Bim, N- 16020 // membrane // inferred from electronic annotation --- Apoptosis // GenMAPP /// 43065 // positive regulation of apoptosis // inferred from electronic terminal annotation IPR007110 // --- 16021 // integral to membrane // inferred from electronic annotation ------Immunoglobulin-like

IPR000648 // Oxysterol- 6810 // transport // inferred from electronic annotation /// 6869 // lipid binding protein /// transport // inferred from electronic annotation /// 8202 // steroid ------IPR002110 // Ankyrin /// metabolism // inferred from electronic annotation IPR001849 // Pleckstrin- like IPR000659 // Vitamin B6 metabolism // ------Pyridoxamine 5'- KEGG phosphate oxidase IPR007635 // Tis11B like 3676 // nucleic acid binding // inferred from electronic annotation /// 3677 // protein, C-terminal /// --- 5634 // nucleus // inferred from electronic annotation DNA binding // inferred from electronic annotation /// 46872 // metal ion --- IPR000571 // Zn-finger, binding // inferred from electronic annotation C-x8-C-x5-C-x3-H type ------

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IPR001611 // Leucine------rich repeat 3676 // nucleic acid binding // inferred from electronic annotation /// 3677 // --- 5634 // nucleus // inferred from electronic annotation DNA binding // inferred from electronic annotation /// 46872 // metal ion ------binding // inferred from electronic annotation IPR001179 // 3755 // peptidyl-prolyl cis-trans isomerase activity // inferred from electronic Peptidylprolyl annotation /// 16853 // isomerase activity // inferred from electronic 6457 // protein folding // inferred from electronic annotation 5634 // nucleus // inferred from electronic annotation --- isomerase, FKBP-type annotation /// 51082 // unfolded protein binding // inferred from electronic /// IPR001440 // TPR annotation repeat ------

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IPR001680 // G-protein ------beta WD-40 repeat

1584 // rhodopsin-like receptor activity // inferred from electronic annotation /// 4871 // signal transducer activity // inferred from electronic 7165 // signal transduction // inferred from electronic annotation /// 7186 // 5887 // integral to plasma membrane // inferred from electronic annotation annotation /// 4872 // receptor activity // inferred from electronic annotation GPCRDB_Class_A_Rhod IPR000276 // Rhodopsin- G-protein coupled receptor protein signaling pathway // inferred from /// 16021 // integral to membrane // traceable author statement /// 4930 // G-protein coupled receptor activity // inferred from electronic opsin-like // GenMAPP like GPCR superfamily electronic annotation annotation /// 45028 // purinergic nucleotide receptor activity, G-protein coupled // inferred from sequence or structural similarity

IPR007635 // Tis11B like 3676 // nucleic acid binding // inferred from electronic annotation /// 3677 // protein, C-terminal /// --- 5634 // nucleus // inferred from electronic annotation DNA binding // inferred from electronic annotation /// 46872 // metal ion --- IPR000571 // Zn-finger, binding // inferred from electronic annotation C-x8-C-x5-C-x3-H type

IPR010533 // Vertebrate 6355 // regulation of transcription, DNA-dependent // inferred from 5634 // nucleus // inferred from electronic annotation 3677 // DNA binding // inferred from electronic annotation --- interleukin-3 regulated sequence or structural similarity transcription factor ------IPR001213 // Mouse mammary tumor virus superantigen /// ------IPR004295 // Env gp36 protein, HERV/MMTV type

1501 // skeletal development // inferred from mutant phenotype /// 8285 // negative regulation of cell proliferation // inferred from mutant phenotype /// 9880 // embryonic pattern specification // inferred from mutant phenotype /// 9952 // anterior/posterior pattern formation // inferred from mutant phenotype /// 30326 // embryonic limb morphogenesis // inferred from 3677 // DNA binding // inferred from sequence or structural similarity /// mutant phenotype /// 35110 // leg morphogenesis // inferred from mutant IPR000210 // BTB/POZ 5634 // nucleus // inferred from direct assay /// 17053 // transcriptional 5515 // protein binding // inferred from physical interaction /// 16566 // phenotype /// 35116 // embryonic hindlimb morphogenesis // inferred from --- domain /// IPR007087 // repressor complex // inferred from sequence or structural similarity specific transcriptional repressor activity // inferred from sequence or mutant phenotype /// 35136 // forelimb morphogenesis // inferred from Zn-finger, C2H2 type structural similarity mutant phenotype /// 43065 // positive regulation of apoptosis // inferred from mutant phenotype /// 45449 // regulation of transcription // inferred from mutant phenotype /// 45892 // negative regulation of transcription, DNA-dependent // inferred from sequence or structural similarity /// 48133 // male germ-line stem cell division // inferred from mutant phenotype 1503 // ossification // inferred from mutant phenotype /// 6955 // immune response // inferred from electronic annotation /// 7275 // development // inferred from electronic annotation /// 9887 // organogenesis // inferred from mutant phenotype /// 30154 // cell differentiation // inferred from electronic annotation /// 30316 // osteoclast differentiation // inferred from 4872 // receptor activity // inferred from electronic annotation /// 5125 // 5615 // extracellular space // inferred from electronic annotation /// 16020 // direct assay /// 30316 // osteoclast differentiation // inferred from genetic cytokine activity // inferred from electronic annotation /// 5164 // tumor IPR006052 // Tumor membrane // inferred from electronic annotation /// 16021 // integral to --- interaction /// 45453 // bone resorption // inferred from direct assay /// necrosis factor receptor binding // inferred from electronic annotation /// Necrosis Factor membrane // traceable author statement 45670 // regulation of osteoclast differentiation // inferred from direct assay 5515 // protein binding // inferred from physical interaction /// 45672 // positive regulation of osteoclast differentiation // inferred from direct assay /// 48535 // lymph node development // traceable author statement /// 51260 // protein homooligomerization // inferred from direct assay ------4197 // cysteine-type endopeptidase activity // inferred from electronic annotation /// 4221 // ubiquitin thiolesterase activity // inferred from IPR001394 // Peptidase 6511 // ubiquitin-dependent protein catabolism // inferred from electronic electronic annotation /// 8233 // peptidase activity // inferred from electronic C19, ubiquitin carboxyl------annotation /// 6512 // ubiquitin cycle // inferred from electronic annotation annotation /// 8234 // cysteine-type peptidase activity // inferred from terminal hydrolase family electronic annotation /// 16787 // hydrolase activity // inferred from 2 electronic annotation ------