International Journal of Molecular Sciences Article AHR Signaling Dampens Inflammatory Signature in Neonatal Skin γδ T Cells Katja Merches 1, Alfonso Schiavi 1,2 , Heike Weighardt 3, Swantje Steinwachs 1, Nadine Teichweyde 1, Irmgard Förster 3 , Katrin Hochrath 1, Beatrix Schumak 4, Natascia Ventura 1,2, Patrick Petzsch 5 , Karl Köhrer 5 and Charlotte Esser 1,* 1 IUF—Leibniz Research Institute for Environmental Medicine, Auf’m Hennekamp 50, D-40225 Düsseldorf, Germany;
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[email protected] (N.V.) 2 Institute of Clinical Chemistry and Laboratory Diagnostic, University of Düsseldorf, Universitätsstrasse 1, D-40225 Düsseldorf, Germany 3 Immunology and Environment, Life & Medical Sciences (LIMES) Institute, University of Bonn, Carl-Troll-Str. 31, D-53115 Bonn, Germany;
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[email protected]; Tel.: +49-211-3389-253 Received: 19 February 2020; Accepted: 20 March 2020; Published: 24 March 2020 Abstract: Background Aryl hydrocarbon receptor (AHR)-deficient mice do not support the expansion of dendritic epidermal T cells (DETC), a resident immune cell population in the murine epidermis, which immigrates from the fetal thymus to the skin around birth.