State of the Field Report 2017

Focused Ultrasound State of the Field 2017

CONTENTS

2 Focused Ultrasound Overview 18 Pre-clinical Research Sites 2 Letter From the Chairman 18 By Region 3 Focused Ultrasound Overview 19 Indications Master Key 20 North America 4 State of the Field 23 Europe 4 State of Research and Regulatory Approval 25 Asia by Indications 26 Oceania 5 2017 Global Development Landscape 6 Historical Change in Stage of Development 27 Clinical Research Sites 7 First in Human Treatments Timeline 27 By Region 7 New FUS Indications by Decade 28 Indications Master Key 8 Treatments by Indication 29 North America 9 Treatments by Indication Each Year 31 South America 10 FUS Publications 32 Europe 10 FUS Citations 36 Asia 10 FUS Media Placements in the U.S. 38 Oceania 10 Total Awards for All FUS NIH Research Grants 11 Abstracts Presented at FUS Symposia 39 Commercial Treatment 12 FUS Approvals by Region and Manufacturer 39 By Indications and Regions 13 FUS Regulatory Approvals by Indication and Region 40 By Country 41 By Region and Indications Master Key 14 Manufacturers 42 North America 14 FUS Manufacturers by Region 43 South America 15 Growth of FUS Manufacturers 44 Europe 15 Timeline of FUS Manufacturers 50 Asia 55 Oceania, Africa 16 Research Trends 56 Cost of Focused Ultrasound Compared to 16 Total Research Sites Growth Standard of Care 16 Total Research Sites by Region 16 Research Sites Growth by Region 58 Focused Ultrasound Foundation 17 Leading Indications by Number of Sites 58 Cumulative Activities 17 Emerging Research Indications by Growth 59 Newsletter Distribution in Number of Sites 59 Website Visits 59 Symposium Attendance and Presentations 59 Cummulative Funding

60 Appendix 60 Bioeffects Research Copyright 2017. All rights reserved. 60 By Region No part of this report may be reproduced in any written, electronic, recording, or 61 North America photocopy form or stored in a retrieval system without written permission of the Focused 64 Europe Ultrasound Foundation. Inquiries for reproduction can be directed to Diana Villalobos 67 Asia, Oceania at [email protected] 70 Technical Research The Focused Ultrasound Foundation strives to provide the most accurate information possible and, therefore works proactively with the manufactures and research sites to 70 By Region collect the most current data available in advance of the release of this publication. 72 North America The Focused Ultrasound Foundation assumes no responsibility for any errors or omissions 73 Europe as every precaution has been taken to verify the accuracy of the information contained 74 Asia herein. No liability is assumed for damages that may result from the use of information contained within. If you note something out of date or inaccurate, please submit the new 75 Manufacturers Contact Information information/updates to: [email protected] 76 Board of Directors and Council

Focused Ultrasound Foundation | State of the Field 2017 1 Dear Friends, The Focused Ultrasound Foundation was established with the vision that this groundbreaking, noninvasive, therapeutic technology would improve the quality of life and decrease the cost of care for millions of patients around the world.

2016 was our most successful year, and as a result we see this vision coming closer to reality. The dialogue has shifted from if focused ultrasound can become a mainstream standard of care to when it will.

The entire focused ultrasound ecosystem, from researchers to manufacturers and treatment sites, continues to grow at an accelerating pace.

The number and diversity of mechanisms by which focused ultrasound affects tissue are expanding, creating the possibility to treat an even wider variety of medical disorders. Indications currently in research, development, and commercialization have skyrocketed to more than 75 from just a handful a decade ago. The numbers of research sites, investigators, regulatory approvals, commercial treatment sites, and patients treated all show impressive growth.

As this momentum builds, the field continues to transition from the research stage to commercialization of the technology. Several years ago there were no organizations providing industry marketing reports on focused ultrasound; today there are 23, a powerful indication of the field’s expansion.

The 2017 State of the Field includes new charts, graphs, and timelines not in previous versions of the report. These additions present a longitudinal view of how the field of focused ultrasound has grown and changed over time, further demonstrating its impressive trajectory.

The Foundation has served as a catalyst, driving growth and advancing the field of focused ultrasound for more than a decade. We are now in the enviable position of needing to further prioritize activities to address mission-critical bottlenecks and leverage resources to provide unique value and measurable impact.

In the coming year, the Foundation will continue to move focused ultrasound beyond the tipping point and accelerate development and adoption. Success will require increased awareness, further funding for research and development, and investment in commercial organizations. We will play an active role in all of these areas to provide resources; connect, convene and influence stakeholders; and foster collaboration.

The revolution continues. Thank you for your continued support and for playing a pivotal role in decreasing death, disability, and suffering for countless people.

Be well,

Neal F. Kassell, MD Chairman

2 Focused Ultrasound Foundation | State of the Field 2017 FOCUSED ULTRASOUND OVERVIEW

The Technology The Focused Ultrasound Foundation Focused ultrasound is an early-stage, disruptive, noninvasive The Foundation is a unique medical research, education, therapeutic technology that has the potential to improve the and advocacy organization created as the catalyst to lives of millions of patients with a variety of serious medical accelerate the development and adoption of focused disorders by providing an alternative or complement to surgery, ultrasound. The Foundation is a tax-exempt 501(c)(3) radiation therapy, drug delivery, and cancer immunotherapy. corporation started in 2006.

This game-changing technology has the potential to increase To achieve its goals, the Foundation utilizes an approach the quality and longevity of life and decrease the cost of care that is entrepreneurial, high impact, high performance, by transforming the treatment of a range of conditions, market driven, and results oriented. including tumors of the brain, breast, prostate, liver and We advance the field by identifying and leveraging pancreas; Parkinson’s and Alzheimer’s disease and epilepsy; opportunities and overcoming barriers, thereby shortening depression and obsessive compulsive disorder; and arthritis the time from laboratory research to widespread patient and hypertension. With further technology development, treatment as a standard of care. laboratory research, and clinical trials, focused ultrasound could be as revolutionary to therapy as MR scanning has Major initiatives include: been to diagnosis. • Influencing the direction of the field, identifying Focused ultrasound treats tissue with multiple intersecting priorities, and defining areas of clinical benefit beams of high-frequency sound focused accurately on targets • Fostering collaboration and stimulating innovation deep in the body without damaging surrounding structures, • Providing resources, both financial and human capital much as beams of light can be focused on a point with a magnifying glass. At the focal point where the beams converge, • Creating knowledge by organizing, conducting, the ultrasound energy induces a variety of biological effects and funding research including destroying tissue, delivering drugs in high • Overcoming barriers, including regulatory and concentrations, enhancing radiation therapy, and stimulating reimbursement challenges the immune response. The multiple biological effects create • Cultivating the next generation of clinicians and the possibility to treat a wide range of disorders. Magnetic scientists by supporting internships and fellowships resonance or ultrasound imaging is used to identify the • Convening the community through meetings, targets and guide and control the treatment in real time. symposia, and workshops The Problem • Increasing awareness through events and media outreach Unfortunately, it can take decades for a new therapeutic technology like focused ultrasound to become mainstream. • Aggregating and sharing knowledge through our Every year shaved off that process could reduce death, website, newsletter, social media, webinars, and disability, and suffering for countless people. open-source journal Saving Time = Saving Lives This work is made possible by the philanthropic support of our donors, who recognize the urgent needs of patients, the potential of focused ultrasound, and the value of the Foundation’s disciplined, entrepreneurial approach.

Focused Ultrasound Foundation | State of the Field 2017 3 STATE OF THE FIELD

State of Research and Regulatory Approval by Indications

Outside US Development stage: Conceptual Pre-clinical Anecdotal Pilot Trials Pivotal Trials Approvals FDA Approvals US Reimbursement

Cardiovascular Neurological Pain Hypertension Essential tremor Back pain, facetogenic Peripheral artery disease Depression Neuropathic pain Arteriovenous malformations Neuropathic pain Osteoid osteoma Atherosclerosis Obsessive-compulsive Back pain, sacroiliitis Atrial fibrillation disorder Painful amputation stump Cardiac dysrythmias Parkinson’s disease neuromas Congestive heart failure Amyotrophic lateral sclerosis Cancer pain Deep vein thrombosis Alzheimer’s disease Hypoplastic left heart Brain cancer syndrome Brain tumors, benign Pediatrics Septal perforation Dystonia Osteoid osteoma Epilepsy Soft tissue tumors, benign Painful amputation stump Brain tumors, benign Endocrine Disorder s neuromas Arteriovenous malformations Thyroid nodules Trigeminal neuralgia Neuroblastoma, pediatric Thyroid cancer Hydrocephalus Diabetes Stroke Obesity Traumatic brain injury Pulmonary Multiple sclerosis Lung metastases Lung cancer Gastrointestinal Liver cancer Oncological Pancreatic cancer Bone metastases Urological Malignant obstructive jaundice Prostate cancer* Benign prostatic hyperplasia* Colorectal cancer Breast cancer Prostate cancer* Esophageal cancer Kidney cancer Kidney cancer Liver cancer Kidney stones Pancreatic cancer Acute kidney injury Miscellaneous Soft tissue cancer Acute tubular necrosis Soft tissue cancer Bone cancer Bladder cancer Soft tissue tumors, benign Brain cancer Ureterocele Head & neck cancer Head & neck cancer Hypersplenism Melanoma Melanoma Thyroid cancer Women’s Health Cervical cancer Uterine fibroids Lung metastases Breast cancer Musculoskeletal Neuroblastoma, pediatric Breast fibroadenoma Bone metastases Bladder cancer Uterine adenomyosis Back pain, facetogenic Cancer pain Tubal pregnancy Osteoid osteoma Colorectal cancer Cervical cancer Back pain, sacroiliitis Esophageal cancer Fetal surgery** Bone cancer Lung cancer Retained placenta accreta Bone tumors, benign Ovarian cancer Ovarian cancer Osteoarthritis Polycystic ovary syndrome Disc degeneration Muscle atrophy Ophthalmological Spinal cord injury Glaucoma

** FDA approval is for prostate tissue ablation. ** Fetal surgery includes twin-twin transfusion syndrome, fetal bladder obstruction, and a range of congenital heart abnormalities.

4 Focused Ultrasound Foundation | State of the Field 2017 STATE OF THE FIELD

2017 Global Development Landscape

Conceptual Pre-clinical Anedotal Pilot Trials Pivotal Trails Outside US Approvals FDA Approvals US Reimbursement

Multiple sclerosis Arteriovenous Amyotrophic lateral Back pain, Benign prostatic Bone metastases Acute kidney injury malformations sclerosis facetogenic hyperplasia* Acute tubular necrosis Cervical cancer Alzheimer’s disease Bone metastases Bone metastases Atherosclerosis Fetal Surgery** Back pain, sacroiliitis Benign prostatic Essential tremor Atrial fibrillation Lung metastases Bone cancer hyperplasia Prostate cancer* Bladder cancer Neuroblastoma, Bone tumors, benign Breast cancer Uterine fibroids Bone metastases pediatric Brain cancer Breast fibroadenoma Cancer pain Retained placenta Brain tumors, benign Depression accreta Cardiac dysrythmias Brain tumors, benign Essential tremor Trigeminal neuralgia Colorectal cancer Dystonia Glaucoma Congestive heart Epilepsy Hypertension failure Head & neck cancer Kidney cancer Deep vein thrombosis Hypersplenism Liver cancer Diabetes Kidney stones Neuropathic pain Disc degeneration Malignant obstructive Obsessive-compulsive Esophageal cancer jaundice disorder Hydrocephalus Melanoma Osteoid osteoma Hypoplastic left heart Painful amputation Pancreatic cancer syndrome stump neuromas Parkinson’s disease Lung cancer Peripheral artery Prostate cancer disease Muscle atrophy Soft tissue cancer Osteoarthritis Obesity Soft tissue tumors, Ovarian cancer Thyroid cancer benign Polycystic ovary Tubal Pregnancy Thyroid nodules syndrome Uterine adenomyosis Septal perforation Uterine fibroids Spinal cord injury Stroke Traumatic brain injury Ureterocele

$ early research $$ clinical trials and commercialization Goal

* FDA approval is for prostate tissue ablation. ** Fetal surgery includes twin-twin transfusion syndrome, fetal bladder obstruction, and a range of congenital heart abnormalities. Early research stages tend to have lower costs and shorter timelines as compared to clinical trials. The significant increase in both expense and time is largely due to increased regulatory requirements that are necessary to ensure patient safety during new medical device evaluation.

Focused Ultrasound Foundation | State of the Field 2017 5 STATE OF THE FIELD

The number of indications has doubled in the last five years with an overall shift toward clinical work and regulatory approval. Development stage: ■ Conceptual ■ Pre-clinical ■ Anecdotal ■ Clinical Trials ■ Outside US Approvals ■ FDA Approvals ■ US Reimbursement Number of indications

2012

2017

0102030405060708090 Indications that have Outside US Approvals, FDA Approval and US Reimbursement are repeated in each category. There are 75 unique indications.

The number of pre-clinical indications and outside US approvals has steadily grown over the past five years. In 2016, US reimbursement was achieved for the first time. Development stage: ■ Conceptual ■ Pre-clinical ■ Anecdotal ■ Clinical Trials ■ Outside US Approvals ■ FDA Approvals ■ US Reimbursement Number of indications

0 2012 2013 2014 2015 2016 2017 Indications that have Outside US Approvals, FDA Approval and US Reimbursement are repeated in each category. There are 75 unique indications.

6 Focused Ultrasound Foundation | State of the Field 2017 STATE OF THE FIELD

First in Human Treatments New FUS Indications Timeline by Decade Clinical trials or commercial treatments Clinical trials or commercial treatments

1950 Brain tumors - craniotomy 48 1951 FUSF 1952 established 1953 40 1954 1955 1956 1957 32 1958 Movement disorder

1983 Vertigo Glaucoma 1984 16 1985 1986 1987 8 1988 1989 1990 1991 1950 1960 1970 1980 1990 2000 2010 2016 1992 Benign prostatic hyperplasia 1993 Prostate cancer Bladder cancer Kidney cancer 1994 Liver cancer 1995 1996 1997 Pancreatic cancer 1998 Breast cancer 1999 2000 Uterine fibroids 2001 Adenomyosis 2002 Breast fibroadenoma 2003 2004 2005 Bone metastases 2006 Osteosarcoma Brain tumors - closed skull Neuropathic pain 2007 Facet arthritis 2008 Osteoid osteoma 2009 Soft tissue tumors, benign 2010 Osteoarthritis Parathyroid cancer 2011 Essential tremor Parkinsonian tremor Thyroid cancer 2012 Hypertension Tubal pregnancy 2013 Fetal surgery Obsessive-compulsive 2014 Hypersplenism disorder 2015 Allergic rhinitis Parkinson’s dyskinesia 2016 Lung metastases Blood–brain barrier Peripheral artery disease Cesarean scar pregnancy Sacral chordoma Depression

Focused Ultrasound Foundation | State of the Field 2017 7 STATE OF THE FIELD

Prostate diseases and uterine fibroids comprise 80% of all treatments.

All Indications Brain Indications

868 Total Brain Treatments

■ Essential Tremor 519 60% ■ Parkinson’s disease 179 21% ■ Neuropathic pain 91 10% ■ Brain tumors 19 2% ■ Obsessive-compulsive disorder 14 2% ■ Depression 5 >1% ■ Dystonia 3 >1% ■ Epilepsy 1 >1% ■ Unspecified** 37 4%

167,993 Total Treatments

■ Uterine fibroids 72,488 43% ■ Bone metastases 1,602 >1% ■ Prostate diseases 61,749 37% ■ Breast cancer 1,269 >1% ■ Liver cancer 18,000 11% ■ Brain 868 >1% ■ Glaucoma 4,900 3% ■ Others* 7,117 4%

Manufacturer supplied data. The number of patient treatments reported is lower than the actual number of procedures because of incomplete reporting from manufacturers and treatment sites. * Back pain, facetogenic; bone cancer; colorectal cancer; kidney cancer; muscular dystrophy; osteoarthritis; osteoid osteoma;pancreatic cancer; soft tissue cancer; thyroid nodules **Not all manufacturers are recording specific indications for brain. The Fo undation is working to clarify this for 2018.

8 Focused Ultrasound Foundation | State of the Field 2017 ■ with focused ultrasoundcontinuetogrow.Patient treatments Focused Ult 2016 2015 2014 Uterine fibroids 0004,0 0008,0 0,0 2,0 4,0 6,0 180,000 160,000 140,000 120,000 100,000 80,000 60,000 40,000 20,000 pain,*Back facetogenic; bonecancer; colorectalcancer; kidneycancer; musculardystrophy; osteoarthritis; osteoidosteoma; pa 0 ■ Others* ■ Prostate diseases ■ Liver cancer ■ Glaucoma ■ Bone metastases ■ Breast cancer rasound Foundation |StateoftheField2017 ■ Brain STATE OFTHEFIELD ■ Others* ncreatic cancer; aofttissuecancer; thyroidnodules 9 STATE OF THE FIELD

FUS Publications FUS Citations Per year Per year

550 20,000 FUSF FUSF established established

440 16,000

330 12,000

220 8,000

110 4,000

0 2000 2016 0 2000 2016 Source: Data from Medline as of February 2017 Source: Web of Science

FUS Media Placements in the US Total Awards for Per year All FUS NIH Research Grants Dollars in millions

350 $35 M FUSF established

280 28

210 21

140 14

70 7

0 2013 2014 2015 2016 0 2004 2016 Source: NIH

10 Focused Ultrasound Foundation | State of the Field 2017 STATE OF THE FIE LD

Abstracts Presented at FUS Symposia ■ Focused Ultrasound Foundation Symposium (FUSF)* ■ European Symposium on Focused Ultrasound Therapy (EUFUS)* ■ International Symposium on Therapeutic Ultrasound (ISTU)

300 FUSF established

240

180

120

0 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 *Held biennially

FUS symposia abstracts continue to trend upwards. FUS media placement at an all-time high. The well-established ISTU symposium attracts FUS Media placements have more than quadrupled in the past researchers annually. With the addition of the FUSF and two years. Additionally, placements in more mainstream EUFUS symposia in the past decade, there has been media venues have increased. Both the FDA approval of an overall increase in the total number of FUS abstracts essential tremor treatment and John Grisham’s The Tumor presented year on year. (See above.) have helped expand awareness for FUS technology beyond the scientific community in the past two years. FUS publications and citations continue trend upwards. Approval of NIH research grants continues at After a steady yearly increase in the number of publications, a steady upward pace. the trend has tapered slightly over the past four years, despite In spite of recent and proposed future NIH funding cuts, the continually increasing number of global research sites focused ultrasound research projects continue to be (see page 16). This slowing trend of publications could be approved for NIH sponsored grants. Over the past decade, a reflection of the number of indications that have progressed the number of NIH grants has fluctuated year to year but from the pre-clinical phase to the clinical phase of the the overall trend is a steady increase since the inception research cycle. The timeline for a clinical study is significantly of the FUS Foundation. longer in duration and, therefore, the availability of data to publish isn’t as frequent. Conversely, the number of citations to FUS research continues to increase year on year.

Focused Ultrasound Foundation | State of the Field 2017 11 STATE OF THE FIELD

FUS Approvals by Region and Manufacturer

North America Europe Asia S. America US Canada Europe Russia China India Japan Korea Mid East Medical Condition FDA Health Canada CE Mark Roszdravnadzor CFDA CDSCO MHLW MFDS Cardiovascular Hypertension ★ Endocrine Thyroid nodules ★ Miscellaneous Soft tissue tumors, benign ★★★ ★ Musculoskeletal Back pain, facetogenic ★ Osteoid osteoma ★★ ★★ ★ Neurological Depression ★ Essential tremor ★★★★ ★★★ Neuropathic pain ★★ ★★ OCD* ★ Parkinsonian tremor ★★ ★★ Oncological Bone metastases ★★★★ ★★ ★★★ ★★★★ Breast cancer ★★★ ★ ★ ★ Kidney cancer ★★★ ★ Liver cancer ★★★★ ★★★ Pancreatic cancer ★ ★★ ★★★ Prostate diseases ★★ ★★ ★★★★ ★★ ★★★★ Soft tissue cancer ★★★ ★ Ophthalmological Glaucoma ★ Women’s Health Breast fibroadenoma ★★ Uterine adenomyosis ★★ ★ ★★★ ★ Uterine fibroids ★★★ ★★★ ★★★ ★★★★★ ★ ★★★ ★★ ★★★ ★★ ★★★★

Manufacturers

★ Alpinion Medical Systems, Korea ★ INSIGHTEC LTD, Israel ★ Shenzhen PRO-HIFU Medical Tech Co., China ★ Beijing Yuande Bio-Medical Engineering, China ★ Kona Medical, USA ★ SonaCare Medical, LLC, USA ★ Chongqing Haifu Medical Technology Co., LTD, China ★ Philips Healthcare, The Netherlands ★ Theraclion, France ★ EDAP TMS S.A., France ★ ★ ★ Profound Medical Inc., Canada Wuxi Haiying Medical, China EyeTechCare, France ★ Shanghai A&S, China *Obsessive-compulsive disorder

12 Focused Ultrasound Foundation | State of the Field 2017 STATE OF THE FIELD

FUS Regulatory Approvals by Indication and Region

Medical Condition 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017

Back pain, facetogenic Bone metastases Bone tumors, benign Breast cancer Breast fibroadenoma Depression Essential tremor Glaucoma Hypertension Kidney cancer Liver cancer Neuropathic pain OCD* Osteoid osteoma Pancreatic cancer Parkinsonian tremor Prostate diseases Soft tissue tumors, benign Soft tissue cancer Thyroid nodules Uterine adenomyosis Uterine fibroids

Regions North America Europe Asia ● United States, FDA ● Europe, CE Mark ● China, CFDA ● Canada, Health Canada ● Russia, Roszdravnadzor ● India, CDSCO ● Japan, MHLW ● South America ● Korea, MFDS ● Mid East

● Oceania *Obsessive-compulsive disorder

Focused Ultrasound Foundation | State of the Field 2017 13 MANUFACTURERS

FUS Manufacturers by Region ■ MR (magnetic resonance) guidance ■ US (ultrasound) guidance ■ MR (magnetic resonance) & US (ultrasound) guidance ■ Transducers ■ Other 11 12 12 North America Europe Asia

■ MR GUIDANCE ■ MR GUIDANCE ■ MR GUIDANCE Image Guided Therapy (IGT) EpiSonica BrainSonix Pessac, France Hsichu City, Taiwan Sherman Oaks, California INSIGHTEC LTD ■ US GUIDANCE Profound Medical Inc. Tirat Carmel, Israel Toronto, Canada Alpinion Medical Systems Medsonic LTD Seoul, Korea ■ US GUIDANCE Limassol, Cyprus Beijing Yuande Bio-Medical Engineering HistoSonics, Inc. Philips Healthcare Beijing, China Ann Arbor, Michigan Eindhoven, The Netherlands Mianyang Sonic (SUONIKE) Electronic International Cardio ■ US GUIDANCE Mianyang, China Corporation, LLC Minnetonka, Minnesota Acublate Shenzhen PRO-HIFU Medical London, UK Tech. Co., LTD Kona Medical Shenzhen, China Bellevue, Washington EDAP TMS S.A. Vaulx-en-Velin, France Shenzhen Wikkon Mirabilis Medical Shenzhen, China Bothell, Washington Theraclion Malakoff, France Sumo Corporations SonaCare Medical, LLC Kowloon, Hong Kong Charlotte, North Carolina ■ MR & US GUIDANCE Supersonic Imagine Wuxi Haiying Medical Verasonics Wuxi, China Redmond, Washington Aix-en-Provence, France ■ ■ MR & US GUIDANCE ■ MR & US GUIDANCE TRANSDUCERS Changjiangyuan Technology FUS Instruments Inc. Imasonic Development Co., LTD Toronto, Canada Voray-sur-l’Ognon, France Shenyang, China ■ OTHER ■ TRANSDUCERS Chongqing Haifu (HIFU) Sonic Concepts CarThera Medical Technology Co., LTD Bothell, Washington Paris, France Chongqing, China EyeTechCare ■ OTHER Shanghai A&S Co., LTD Rillieux-la-Pape, France Shanghai, China FUS Mobile Alpharetta, Georgia Promedica Bioelectronics ■ Rome, Italy OTHER NaviFUS New Taipei City, Taiwan

Manufacturer Criteria: Ultrasound technology must be 1) therapeutic 2) non-invasive 3) focused 4) image-guided. Contact info for all manufacturers can be found on page 73.

14 Focused Ultrasound Foundation | State of the Field 2017 MANUFACTURERS

The number of FUS manufacturers continues to increase. ■ MR guidance ■ US guidance ■ MR & US guidance ■ Transducers ■ Other Number of manufacturers

35 FUSF established

0 1979 2000 2016 Source: Manufacturer supplied data

Timeline of FUS Manufacturers

BrainSonix Medsonic EpiSonica Image Guided Therapy Philips Healthcare INSIGHTEC Profound Medical Inc. MR guidance

SonaCare Mianyang Sonic Shenzhen PRO-HIFU HistoSonics, Inc. Shenzhen Wikkon Mirabilis Medical International Cardio Corp. EDAP TMS Sumo Corporations Verasonics Theraclion Kona Medical US guidance

Beijing Yuande Bio-Medical Engineering Wuxi Haiying Medical Alpinion Acublate

Changjiangyuan Tech Supersonic Imagine Chongqing HAIFU Shanghai A&S FUS Instruments MR & US guidance

Sonic Concepts

Imasonic Transducers

FUS Mobile CarThera NaviFUS EyeTechCare Promedica Bioelectronics Other

79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 00 01 02 03 04 05 06 07 08 09 10 11 12 13 14 15 16

Focused Ultrasound Foundation | State of the Field 2017 15 RESEARCH TRENDS

Total Research Sites Growth Total Research Sites by Region January 2014 to January 2017 January 2017

325 1 4 316 Sites 260 ■ North America 92 102 ■ Europe 195 ■ Asia ■ Oceania ■ 130 South America 117

0 1/14 1/15 1/16 1/17

Pre-clinical Sites Clinical Sites January 2014 to January 2017 January 2014 to January 2017

125 200

100 160

75 120

50 80

25 40

0 1/14 1/15 1/16 1/17 0 1/14 1/15 1/16 1/17

■ North America ■ Asia ■ Total ■ North America ■ Asia ■ Total ■ Europe ■ Oceania ■ Europe ■ Oceania ■ South America

16 Focused Ultrasound Foundation | State of the Field 2017 RESEARCH TRENDS

Leading Indications by Number of Sites

Pre-clinical | Number of sites

1. 33 Brain cancer

2. 32 Uterine fibroids

3. 31 Bone metastases 31 Brain tumors 31 Breast cancer 0 1224364860728496

Clinical | Number of sites

1. 86 Uterine fibroids

2. 57 Prostate cancer

3. 32 Bone metastases

4. 30 Osteoid osteoma

5. 27 Liver cancer 27 Breast cancer 0 1224364860728496

Emerging Research Indications by Growth in Number of Sites

Pre-clinical Clinical

Number of Sites Number of Sites Indications 2016 2017 % change Indications 2016 2017 % change

Parkinson’s disease 6 11 83 Brain cancer 7 10 43

Back pain, facetogenic 9 13 44 Pancreatic cancer 13 17 31

Osteoid osteoma 8 10 25 Back pain, facetogenic 9 11 22

Kidney cancer 13 16 23 Parkinson's disease 9 11 22

Brain cancer 27 33 22 Prostate cancer 52 57 10

Focused Ultrasound Foundation | State of the Field 2017 17 PRE-CLINICAL

22 new pre-clinical research sites were added in 2016.

123 Pre-clinical research sites worldwide 59 35 26 North America Europe Asia 3 Oceania

Pre-clinical research sites are any site conducting non-human FUS research to collect data in support of the safety or feasibility of clinical applications.

18 Focused Ultrasound Foundation | State of the Field 2017 PRE–CLINICAL

Master key all regions 63 indications are being researched at pre-clinical sites worldwide.

Cardiovascular Miscellaneous Neurological ✪ Cervical cancer Pediatrics ✚ Atherosclerosis ✖ Glaucoma ■ Alzheimer’s disease ✪ Colorectal cancer ✱ Neuroblastoma, pediatric ✚ Atrial fibrillation ✖ Head & neck cancer ■ Amyotrophic lateral ✪ Esophageal cancer ✱ Osteoid osteoma ✚ Cardiac dysrythmias ✖ Melanoma sclerosis ✪ Head & neck cancer ✱ Soft tissue tumors, benign ✚ Congestive heart failure ✖ Soft tissue cancer ■ Brain cancer ✪ Kidney cancer ✚ Deep vein thrombosis ✖ Soft tissue tumors, benign ■ Brain tumors, benign ✪ Liver cancer Urological ✚ Hypertension ■ Depression ✪ Lung cancer ◆ Acute tubular necrosis ✚ Peripheral artery disease Musculoskeletal ■ Epilepsy ✪ Melanoma ◆ Benign prostatic hyperplasia ✚ Septal perforation ● Back pain, facetogenic ■ Essential tremor ✪ Neuroblastoma, pediatric ◆ Bladder cancer ● Back pain, sacroiliitis ■ Hydrocephalus ✪ Ovarian cancer ◆ Kidney cancer Endocrine Disorders ● Bone cancer ■ Neuropathic pain ✪ Pancreatic cancer ◆ Kidney stones ▲ Diabetes ● Bone metastases ■ Painful amputation stump ✪ Prostate cancer ◆ Prostate cancer ▲ Obesity ● Bone tumors, benign neuromas ✪ Soft tissue cancer ◆ Ureterocele ▲ Thyroid cancer ● Disc degeneration ■ Parkinson’s disease ✪ Thyroid cancer ▲ Women’s Health Thyroid nodules ● Muscle atrophy ■ Stroke ● Osteoarthritis ■ Pain ✿ Breast cancer Gastrointestinal Traumatic brain injury ● Osteoid osteoma ■ ▼ Back pain, facetogenic ✿ Breast fibroadenoma ✤ Trigeminal neuralgia Colorectal cancer ● Spinal cord injury ▼ Back pain, sacroiliitis ✿ Cervical cancer ✤ Esophageal cancer Oncological ▼ Cancer pain ✿ Fetal surgery ✤ Liver cancer ✪ Bladder cancer ▼ Neuropathic pain ✿ Ovarian cancer ✤ Pancreatic cancer ✪ Bone cancer ▼ Osteoid osteoma ✿ Polycystic ovary syndrome ✪ Bone metastases ▼ Painful amputation stump ✿ Uterine adenomyosis ✪ Brain cancer neuromas ✿ Uterine fibroids ✪ Breast cancer ✪ Cancer pain

Pre-clinical research sites are any site conducting non-human FUS research to collect data in support of the safety or feasibility of clinical applications.

Focused Ultrasound Foundation | State of the Field 2017 19 PRE-CLINICAL

North America 59 Sites by Region Endrocrine Gastro- Women’s Canada Cardiovascular Disorders intestinal Misc. Musculoskeletal Neurological Onocological Pain Peds Urological Health Lawson Health Research Institute ✤ ■ ■ ✪ ✪ ✪◆ Ryerson University ✪✿ Sunnybrook Health Sciences Centre ✚▲✤ ✖✖ ● ● ■ ■ ■ ■ ✪ ✪ ✪ ✪ ▼ ✱ ◆ ✿ ✿ ■ ■ ■ ■ ✪ ✪ ✪ The Hospital for Sick Children (SickKids) ✖ ● ● ● ■ ■ ■ ■ ✪ ✪ ✪ ✪ ▼ ✱ ✱ ◆ ✿ ✪ ✪ Thunder Bay Regional Research Institute ✪ ✪◆✿ ✿ University of Alberta ✪◆

United States Artann Laboratories ✪ ✪◆✿ Boston University ✚ ✚ ✖ ■ ■ ✪ ✪ ✪ ✪ ◆ ✿ Brigham and Women’s Hospital ■ ■ ■ ■ ✪ ✿

BURL Concepts Inc. ■ ■ ■ ✪ ✱

CHI St. Luke’s Health ✿ Children’s National Health System ✚ ✖ ● ● ● ■ ■ ■ ✪ ✪ ✪ ▼ ▼ ▼ ✱ ✱ ◆ Cincinnati Children’s Hosp. Medi. Center ▲ ▲ ✖ ● ● ✪ ✱

Region | North America* Miscellaneous ■ Brain cancer ✪ Cervical cancer Pediatrics ✖ Head & neck cancer ■ ✪ ✱ Cardiovascular Brain tumors, benign Colorectal cancer Neuroblastoma, pediatric ✖ Melanoma ■ ✪ ✱ Osteoid osteoma ✚ Atherosclerosis Depression Esophageal cancer ✖ Soft tissue cancer ■ ✪ ✱ Soft tissue tumors, benign ✚ Cardiac dysrythmias Epilepsy Head & neck cancer ✚ ✖ Soft tissue tumors, benign ■ Essential tremor ✪ Kidney cancer Congestive heart failure ■ ✪ Urological ✚ Deep vein thrombosis Musculoskeletal Hydrocephalus Liver cancer ◆ Bladder cancer ✚ ● ■ Neuropathic pain ✪ Melanoma ◆ Hypertension Back pain, facetogenic ■ ✪ Kidney cancer ✚ Peripheral artery disease ● Back pain, sacroiliitis Painful amputation stump Neuroblastoma ◆ Kidney stones neuromas ✪ ✚ Septal perforation ● Bone cancer Pancreatic tumors ◆ Prostate cancer ■ Parkinson’s disease ✪ ● Bone metastases Prostate cancer ◆ Ureterocele Endocrine Disorders ■ Stroke ✪ ▲ ● Bone tumors, benign Soft tissue cancer Diabetes ■ Traumatic brain injury ✪ Women’s Health ▲ ● Muscle atrophy Thyroid cancer Obesity ■ Trigeminal neuralgia ✿ Breast cancer ● Osteoarthritis ▲ Thyroid cancer Pain ✿ Breast fibroadenoma ● Osteoid osteoma Oncological ▼ ▲ Thyroid nodules Back pain, facetogenic ✿ Cervical cancer ● Spinal cord injury ✪ Bladder cancer ▼ Back pain, sacroiliitis ✿ Fetal surgery Gastrointestinal ✪ Bone cancer ▼ ✤ Neurological Cancer pain ✿ Polycystic ovary syndrome Colorectal cancer ✪ Bone metastases ▼ ✤ ■ Alzheimer’s disease Neuropathic pain ✿ Uterine adenomyosis Esophageal cancer ✪ Brain cancer ▼ ✤ ■ Amyotrophic lateral Osteoid osteoma ✿ Uterine fibroids Liver cancer ✪ Breast cancer ✤ sclerosis Pancreatic cancer ✪ Cancer pain

Pre-clinical research sites are any site conducting non-human FUS research to collect data in support of the safety or feasibility of clinical applications. *Indications not being researched in a region have been removed from the key.

20 Focused Ultrasound Foundation | State of the Field 2017 PRE–CLINICAL

Endrocrine Gastro- Women’s Cardiovascular Disorders intestinal Misc. Musculoskeletal Neurological Onocological Pain Peds Urological Health United States continued City of Hope ✤ ✪ ✪ ✪ ◆ ✿ Columbia University ✤ ✤ ■ ■ ✪ ✪ ✪ ✿ ✿ Drexel University ✤ ✤ ●✪✪ ✪ ✪ ✿ Duke University ■ ✿ Food and Drug Administration Fox Chase Cancer Center ●✪✪ ✪ ◆ ✿ Georgia Institute of Technology ■ ■ ✪ Indiana University Health, Univ. Hospital ✪ ◆ Johns Hopkins University School ▲ ✤ ■ ■ ■ ✪ ✪ ✪ ✪ ◆ ◆ of Medicine ✪ Mayo Clinic - Minnesota ✖ ● ● ●✪✪ ✪ ▼▼ ◆ ✿ Medical University of South Carolina ✤ ■ ■ ✪ ✪ Memorial Sloan-Kettering Cancer Center ● ●✪✪ ▼▼ Montefiore Medical Center ✪ ◆ National Institutes of Health ✚ ✤ ✤ ● ✪ ✪ ✿ Northeastern University ■ Oklahoma State University ✚ ✤ ✖ ● ✪ ✪ ✪ ✪ ◆ San Diego State University ✤ ✪ ✪ ✿ Stanford University School of Medicine ✤ ✖ ● ● ● ■ ■ ■ ■ ✪ ✪ ✪ ✪ ▼▼ ✱ ◆ ◆ ✿ ✪ ✪ ✪

SUNY Upstate Medical University ● ● ■ ✪ ✪ Swedish Neurosciences Institute ■ ■ The Methodist Hospital ✚ ✤ ■ ✪ ✪ ✿ Tulane University ✚ ▲ ▲ ▲ ✤ ● ● ■ ✪ ✪ ✪ ✪ ▼ ◆ ◆ ✿ ✪ University of California Davis ✤ ✤ ✖ ✖ ■ ✪ ✪ ✪ ✪ ◆ ✿ ✪ ✪ ✪ University of California Los Angeles ● ■ ■ ✪ ✪ ✪ ◆ ✿ University of California San Francisco ✤ ✖ ● ● ● ● ✪ ✪ ✪ ✪ ▼▼ ✱ ✱ ◆ ◆ ✿ ● ● ✪ University of Chicago ✚ ●✪✪ ✪◆✿ ✿ University of Cincinnati ✚ ✚ ✤ ■ ✪ University of Illinois at Urbana-Champaign ✤ ✖ ✖ ✪ ✪ ✪ ✱ ✿ University of Kansas ✚ ✖ ✖ ✪ ✪ ✱ ✿ University of Maryland School of Medicine ✖ ● ■ ■ ✪ ✪ ✪ ✿ University of Michigan ✚ ■ ■ ■ ✪ ✪ ◆ ◆ ✿ University of Minnesota ✚ ✚ ✤ ● ■ ■ ■ ✪ ▼▼ ✿

Pre-clinical research sites are any site conducting non-human FUS research to collect data in support of the safety or feasibility of clinical applications.

Focused Ultrasound Foundation | State of the Field 2017 21 PRE-CLINICAL

Endrocrine Gastro- Women’s Cardiovascular Disorders intestinal Misc. Musculoskeletal Neurological Onocological Pain Peds Urological Health United States continued University of Pennsylvania ✤ ✪ University of Southern California Keck Hosp. ✪ ✪ ◆ ◆ University of Texas at Austin ■ University of Texas MD Anderson ✤ ✤ ■ ■ ✪ ✪ ✪ ✪ ◆ ✿ Cancer Center ✪ University of Texas Southwestern ● ● ✪ ▼▼ ✱ ✱ ◆ ✿ Medical Center University of Utah ✚ ● ■ ✪ ✿ ✿ University of Virginia Health System ● ■ ■ ■ ■ ✪ ✪ ✿ ■ University of Washington ✚ ✚ ✚ ▲ ✤ ✤ ✤ ✖ ✖ ● ■ ■ ■ ✪ ✪ ✪ ✪ ▼ ✱ ◆ ◆ ◆ ✿ ✪ ✪ ✪ ✪ ◆ ◆ ✪ ✪ ✪ Urology Centers of Alabama ✪◆ Vanderbilt University ✤ ✪✪ ✿ ✿ Wake Forest University Baptist ✖ ✖ ■ ■ ✪ ✪ ✱ Medical Center Washington University in St. Louis ✚ Weill Cornell Medical Center ●✪ ✿ Worcester Polytechnic Institute ■ ■ ✪

Pre-clinical research sites are any site conducting non-human FUS research to collect data in support of the safety or feasibility of clinical applications.

22 Focused Ultrasound Foundation | State of the Field 2017 PRE–CLINICAL

Europe 35 Sites by Region Endrocrine Gastro- Women’s Cyprus Cardiovascular Disorders intestinal Misc. Musculoskeletal Neurological Onocological Pain Peds Urological Health Cyprus University of Technology ✚ ✤ ● ● ■ ■ ■ ■ ✪ ✪ ✪ ✪ ✪

France Centre Léon Bérard ✤ ✤ ✪ ✪ ✪ ✿

CHU de Bordeaux - Hôpital Saint-André ✤ ✪ ✿ ✿ Hôpital A. Michallon ✖ Hôpital Cochin ✤ ✪ Hospices Civils de Lyon ✖ ✪◆ Inserm Lyon ✚ ✚ ✚ ✤ ✤ ✖ ● ■ ✪ ✪ ✪ ✪ ▼ ◆ ◆ ✿ ✪ ✪

Institut Langevin–EXPCI ■ ■ ■ ■ ■

Germany German Cancer Research Center Heidleberg ✤ ■ ■ ✪ ✪ ✪◆ Klinikum Fürth ✪◆

SRH Waldklinikum Gera ✪ University Hospital of Cologne ✤ ● ● ✪ ✪ ✪ ✪ ▼ University Hospital Schleswig-Holstein ✤ ✪ ✿

Region | Europe* Musculoskeletal ■ Painful amputation stump Pain Urological ● ▼ ◆ Kidney cancer Cardiovascular Back pain, facetogenic neuromas Back pain, facetogenic ● Back pain, sacroiliitis ■ Parkinson’s disease ▼ Back pain, sacroiliitis ◆ Kidney stones ✚ Atherosclerosis ● Bone cancer ■ Stroke ▼ Cancer pain ◆ Prostate cancer ✚ Atrial fibrillation ● Bone metastases ■ Trigeminal neuralgia ▼ Neuropathic pain ✚ Cardiac dysrythmias Women’s Health ● Disc degeneration ▼ Osteoid osteoma ✚ Deep vein thrombosis Oncological ✿ Breast cancer ● Muscle atrophy ▼ Painful amputation stump ✪ Bone cancer ✿ Fetal surgery Gastrointestinal ● Osteoarthritis neuromas ✪ Bone metastases ✿ Uterine adenomyosis ✤ Liver cancer ● Osteoid osteoma ✪ Brain cancer Pediatrics ✿ Uterine fibroids ✤ Pancreatic cancer Neurological ✪ Breast cancer ✱ Osteoid osteoma Miscellaneous ■ Alzheimer’s disease ✪ Cancer pain ✱ Soft tissue tumors, benign ✖ Glaucoma ■ Brain cancer ✪ Kidney cancer ✖ Soft tissue tumors, benign ■ Brain tumors, benign ✪ Liver cancer ■ Depression ✪ Lung cancer ■ Epilepsy ✪ Pancreatic cancer ■ Essential tremor ✪ Prostate cancer ■ Neuropathic pain

Focused Ultrasound Foundation | State of the Field 2017 23 PRE-CLINICAL

Endrocrine Gastro- Women’s Cardiovascular Disorders intestinal Misc. Musculoskeletal Neurological Onocological Pain Peds Urological Health Germany continued University of Heidelberg ■ ■ ■ ■ ✪ ■ University of Munich ●▼✱

Israel Chaim Sheba Medical Center ● ■ ■ ✪ ✪ ✪◆✿ ✿ Rambam Medical Center ● ■ ✪

Italy European Institute of Oncology ✤ ✪ Istituto Ortopedico Rizzoli ✖ ● ● ● ● ■ ■ ✪ ✪ ✪ ▼▼▼ ✱ ✱ ● ● ● ● ▼▼▼ Scuola Superiore Sant’Anna ✚ ✪ ◆ University of Turin ✪ ✿

The Netherlands University Medical Center Utrecht ✤ ✤ ✪ ✪ ✪ ◆

Norway Oslo University Hospital Rikshopitalet ✤ ✪ ✿

Spain Hospital Clínico San Carlos ✖ Instituto Cartuja de Técnicas Avanzadas ●✪ ✿ en Medicina La Paz University Hospital ■

Switzerland University of Zurich, Children’s Hospital ■ ■ ■ ✪ Geneva University Hospital ✖ University of Geneva ✤ ✪

United Kingdom Churchill Hospital ✿ Imperial College London ✿ Institute for Medical Science and ✚ ✤ ● ● ■ ■ ■ ■ ✪ ✪ ✪ ✪ ▼ ◆ ◆ ✿ Technology ■ ■ ✪ ✪ St. Mary’s Hospital ✤ ● ● ■ ✪ ✪ ✪ ▼ ◆ ◆ ✿ The Institute of Cancer Research ●✪ University of Dundee ●✪

Pre-clinical research sites are any site conducting non-human FUS research to collect data in support of the safety or feasibility of clinical applications.

24 Focused Ultrasound Foundation | State of the Field 2017 PRE–CLINICAL

Asia 26 Sites by Region Endrocrine Gastro- Women’s China Cardiovascular Disorders intestinal Misc. Musculoskeletal Neurological Onocological Pain Peds Urological Health Chongqing Medical University ✤ ✖ ● ✪ ✪ ✪ ✿ ✿ ✿ Fundan University Shanghai Cancer Center ●✪ ✿

HAIFU Hospital ✤ ✖ ● ✪ ✪ ✪ ▼ ✱ ✱ ◆ ✿ ✿ Peking Union Hospital, Chinese ✤ ✪ Academy of Medical Sciences

PLA 301 Hospital (General Hospital of ✤ ✖ ● ✪ ✪ ✪ ▼ ✱ ✱ ◆ ✿ ✿ the People’s Liberation Army) Southern Medical University ✪✿ Sun Yat-Sen University ■ Wenzhou Medical University ■ ■ ✪

India

GSL Medical College ● ●✪▼ ✿ Jaslok Hospital and Research Centre ✿

Iran Iran University of Medical Sciences ✤ ✪

Region | Asia* Musculoskeletal Oncological Pain Women’s Health ● ✪ Bone cancer ▼ ✿ Breast cancer Cardiovascular Back pain, facetogenic Back pain, facetogenic ● ✪ Bone metastases ▼ Osteoid osteoma ✿ Breast fibroadenoma ✚ Congestive heart failure Bone cancer ● ✪ Brain cancer ✿ Fetal surgery ✚ Hypertension Bone metastases Pediatrics ● Osteoarthritis ✪ Breast cancer ✿ Ovarian cancer ✱ Osteoid osteoma Endocrine Disorders ● Osteoid osteoma ✪ Cervical cancer ✿ Uterine adenomyosis ✱ Soft tissue tumors, benign ▲ Diabetes ✪ Colorectal cancer ✿ Uterine fibroids Neurological ✪ Kidney cancer Urological Gastrointestinal ■ Alzheimer’s disease ✪ Liver cancer ◆ Acute tubular necrosis ✤ Colorectal cancer ■ Brain cancer ✪ Lung cancer ◆ Benign prostatic hyperplasia ✤ Liver cancer ■ Brain tumors, benign ✪ Ovarian cancer ◆ Kidney cancer ✤ Pancreatic cancer ■ Depression ✪ Pancreatic tumors ◆ Kidney stones ■ Parkinson’s disease Miscellaneous ✪ Prostate cancer ◆ Prostate cancer ■ Stroke ✖ Soft tissue cancer ✪ Soft tissue cancer ✖ Soft tissue tumors, benign

Focused Ultrasound Foundation | State of the Field 2017 25 PRE-CLINICAL

Endrocrine Gastro- Women’s Japan Cardiovascular Disorders intestinal Misc. Musculoskeletal Neurological Onocological Pain Peds Urological Health Breastopia Namba Hospital ✪✿ Kochi University Hospital ● ● ▼ Osaka University ✚ Tohoku University ✿

Republic of Korea Asan Medical Center ✤ ✪ Chaum Hospital ●✪ ✿ ✿ Seoul National University Hospital ✤ ✖ ✖ ● ■ ✪ ✪ ✪ ✪ ✱ ✿ ✿ The Catholic University of Korea ■ ■ ■

Singapore Nanyang Technological University ✚ ▲ ✤ ✤ ■ ✪ ✪ ✪ ✪ ◆ ◆ ◆ ✿ ✿ ✿ ✪ ✪ ◆ ◆

Taiwan Academia Sinica ✪ ✪ ✿ Chang Gung University ■ ■ ✪ National Taiwan University ■ ■ ✪ National Tsing Hua University ■ ■ ■ ✪ National Yang-Ming University ■✪ ◆ Taipei Medical University Hospital ✪◆

Oceania 3 Sites by Region Endrocrine Gastro- Women’s Australia Cardiovascular Disorders intestinal Misc. Musculoskeletal Neurological Onocological Pain Peds Urological Health Future Medical Imaging Group ✖ ● ● ● ✪ ▼ ✱ ✿ ✿ Royal Women’s Hospital Melbourne ●✪ ✿ ✿ University of Queensland ■ ■

Region | Oceania* Musculoskeletal Neurological Oncological Pediatrics ● Bone metastases ■ Alzheimer’s disease ✪ Bone metastases ✱ Osteoid osteoma Miscellaneous ● Osteoarthritis ■ Amyotrophic lateral ✖ Soft tissue tumors, benign Pain Women’s Health ● Osteoid osteoma sclerosis ▼ Osteoid osteoma ✿ Uterine adenomyosis ✿ Uterine fibroids

26 Focused Ultrasound Foundation | State of the Field 2017 CLINICAL

14 new clinical research sites were added in 2016.

195 Clinical research sites worldwide 55 83 53 North America Europe Asia 1 3 South America Oceania

Clinical research sites are any site treating patients as part of a clinical study.

Focused Ultrasound Foundation | State of the Field 2017 27 CLINICAL

Master key all regions 39 indications are being researched at clinical sites worldwide.

Cardiovascular Musculoskeletal Oncological Pain Urological ✚ Hypertension ● Back pain, facetogenic ✪ Bone cancer ▼ Back pain, facetogenic ◆ Benign prostatic hyperplasia ✚ Peripheral artey disease ● Back pain, sacroiliitis ✪ Bone metastases ▼ Back pain, sacroiliitis ◆ Kidney cancer ● Bone cancer ✪ Brain cancer ▼ Neuropathic pain ◆ Kidney stones Endocrine Disorders ● Bone metastases ✪ Breast cancer ▼ Osteoid osteoma ◆ Prostate cancer ▲ Thyroid cancer ● Osteoarthritis ✪ Head & neck cancer ▼ Painful amputation stump ▲ Women’s Health Thyroid nodules ● Osteoid osteoma ✪ Kidney cancer neuromas ✿ ✪ Liver cancer Breast cancer Gastrointestinal ✿ Neurological ✪ Melanoma Pediatrics Breast fibroadenoma ✤ Liver cancer ✿ ■ Alzheimer’s disease ✪ Pancreatic cancer ✱ Osteoid osteoma Tubal pregnancy ✤ Malignant obstructive ✿ ■ Amyotrophic lateral ✪ Prostate cancer ✱ Soft tissue tumors, benign Uterine adenomyosis jaundice ✿ sclerosis ✪ Soft tissue cancer Uterine fibroids ✤ Pancreatic cancer ■ Brain cancer ✪ Thyroid cancer ■ Brain tumors, benign Miscellaneous ■ Depression ✖ Glaucoma ■ Epilepsy ✖ Head & neck cancer ■ Essential tremor ✖ Hypersplenism ■ ✖ Neuropathic pain Melanoma ■ Obsessive-compulsive ✖ Soft tissue cancer disorder ✖ Soft tissue tumors, benign ■ Painful amputation stump neuromas ■ Parkinson’s disease

Clinical research sites are any site treating patients as part of a clinical study.

28 Focused Ultrasound Foundation | State of the Field 2017 Focused Ultrasound Foundation CLINICAL

North America 55 Sites by Region Endrocrine Gastro- Women’s Canada Cardiovascular Disorders intestinal Misc. Musculoskeletal Neurological Onocological Pain Peds Urological Health Jewish General Hospital ✪◆ London Health Sciences Centre ✪◆ Princess Margaret Hospital ✪◆ Sunnybrook Health Sciences Centre ✖ ● ■ ■ ■ ■ ✪ ✪ ✪ ✪◆✿ ■ ■ The Hospital for Sick Children (SickKids) ●▼✱ Thunder Bay Regional Research Institute ✿ Toronto General Hospital ●✪ ✿ Toronto Western Hospital ■ University of Western Ontario ✪◆

United States Arkansas Heart Hospital ✚ Brigham and Women’s Hospital ■ ■ ■ ✪ ✪◆✿

CHI St. Luke’s Health ✿ Children’s National Health System ✖ ●▼✱ ✱ Cincinnati Children’s Hosp. Medi. Center ✖ ●▼✱ ✱ City of Hope ●✪✪◆ Cleveland Clinic ✪◆ Duke University ✿ Grand Strand Urology ✪◆ Henry Ford Hospital ✪◆

Regions Cardiovascular Neurological Oncological Pediatrics North America* ✚ Peripheral arteryl disease ■ Alzheimer’s disease ✪ Bone metastases ✱ Osteoid osteoma South America* ■ ✪ Brain cancer ✱ Miscellaneous Amyotrophic lateral Soft tissue tumors, benign sclerosis ✪ Head & neck cancer ✖ Head & neck cancer Urological ■ Brain cancer ✪ Kidney cancer ✖ Melanoma ◆ Benign prostatic hyperplasia ■ Brain tumors, benign ✪ Melanoma ✖ Soft tissue cancer ◆ Kidney cancer ■ Epilepsy ✪ Prostate cancer ✖ Soft tissue tumors, benign ◆ Prostate cancer ■ Essential tremor ✪ Soft tissue cancer Musculoskeletal ■ Women’s Health Neuropathic pain Pain ● Back pain, facetogenic ■ Parkinson’s disease ✿ Breast fibroadenoma ▼ Back pain, facetogenic ● Bone metastases ✿ Uterine fibroids ▼ Neuropathic pain ● Osteoid osteoma ▼ Osteoid osteoma

Clinical research sites are any site treating patients as part of a clinical study. *Indications not being researched in a region have been removed from the key.

Focused Ultrasound Foundation | State of the Field 2017 29 CLINICAL

Endrocrine Gastro- Women’s Cardiovascular Disorders intestinal Misc. Musculoskeletal Neurological Onocological Pain Peds Urological Health United States continued Indiana University Health, University ✪◆ Hospital Johns Hopkins University School of ✪◆ Medicine Mayo Clinic - Minnesota ✖ ● ●✪✪ ▼ ✿ Memorial Sloan-Kettering Cancer Center ✪◆ Metropolitan Urology ✪◆ Miami Children’s Hospital ■ ■ ■ ✪ Montefiore Medical Center ✪◆✿ New York-Presbyterian Hospital ✿ New York University - Langone Medical ✪◆ Center Ohio State University ■ Oregon Health and Science University ✿ ProMedica Toledo Hospital ◆ Southeast Urology Network ✪◆ Sperling Prostate Center ✪◆ Stanford University School of Medicine ✖ ● ● ● ■ ✪ ✪ ▼ ▼ ✱ ✱ ◆ ✿ Swedish Neurosciences Institute ■ ■ ■ ■ ✪ University Hospitals of Cleveland Case ✪◆ Medical Center University MRI & Diagnostic Imaging ✿ Centers - South University of California Los Angeles ✪◆✿ University of California San Diego ✿ Thornton Hospital University of California San Francisco ✖ ● ● ● ✪ ✪ ▼ ▼ ✱ ✱ ◆ ✿ University of Chicago ✪◆✿ University of Maryland School of ■ ■ ■ ■ ✪ ▼ Medicine University of Michigan ◆ ✿ University of Southern California Keck ✪ ✪ ◆ ◆ Hospital University of Texas MD Anderson ✿ Cancer Center University of Texas Southwestern ● ✪ ▼ ✱ ◆ ✿ Medical Center University of Virginia Health System ✖ ■ ■ ✪ ✪◆✿

Clinical research sites are any site treating patients as part of a clinical study.

30 Focused Ultrasound Foundation | State of the Field 2017 Focused Ultrasound Foundation CLINICAL

Endrocrine Gastro- Women’s Cardiovascular Disorders intestinal Misc. Musculoskeletal Neurological Onocological Pain Peds Urological Health United States continued University of Wisconsin Carbone ✪◆ Cancer Center Urology Centers of Alabama ✪◆ Urology of San Antonio ✪◆ Vanderbilt University ✿ Walter Reed National Military Medical ✿ Center Weill Cornell Medical Center ✿ William Beaumont Health Systems ✪◆ Winthrop University Hospital ✪◆

South America 1 Sites by Region Endrocrine Gastro- Women’s Brazil Cardiovascular Disorders intestinal Misc. Musculoskeletal Neurological Onocological Pain Peds Urological Health Instituto do Cancer do Estado de ● ● ● ✪ ▼ ▼ ✱ ✿ Sao Paulo

Regions Cardiovascular Neurological Oncological Pediatrics North America* ✚ Peripheral artery disease ■ Alzheimer’s disease ✪ Bone metastases ✱ Osteoid osteoma South America* ■ ✪ Brain cancer ✱ Miscellaneous Amyotrophic lateral Soft tissue tumors, benign sclerosis ✪ Head & neck cancer ✖ Head & neck cancer Urological ■ Brain cancer ✪ Kidney cancer ✖ Melanoma ◆ Benign prostatic hyperplasia ■ Brain tumors, benign ✪ Melanoma ✖ Soft tissue cancer ◆ Kidney cancer ■ Epilepsy ✪ Prostate cancer ✖ Soft tissue tumors, benign ◆ Prostate cancer ■ Essential tremor ✪ Soft tissue cancer Musculoskeletal ■ Women’s Health Neuropathic pain Pain ● Back pain, facetogenic ■ Parkinson’s disease ✿ Breast fibroadenoma ▼ Back pain, facetogenic ● Bone metastases ✿ Uterine fibroids ▼ Neuropathic pain ● Osteoid osteoma ▼ Osteoid osteoma

Clinical research sites are any site treating patients as part of a clinical study. *Indications not being researched in a region have been removed from the key.

Focused Ultrasound Foundation | State of the Field 2017 31 CLINICAL

Europe 83 Sites by Region Endrocrine Gastro- Women’s Austria Cardiovascular Disorders intestinal Misc. Musculoskeletal Neurological Onocological Pain Peds Urological Health Medical University of Vienna ✚ ✪◆

Belgium Institut Jules Bordet ✪◆

Czech Republic Mestska Nomocnice Ostrava ✚ Na Homolce Hospital ✚ St. Anne’s Hospital ✚ Thomayer University Hospital ✿ University Hospital - Brno ✚

France Centre Léon Bérard ✤ ✤ ✪ ✪ ✪ ✿

CHU de Bordeaux - Hôpital du Tondu ✪◆

CHU de Bordeaux - Hôpital Saint-André ✚ ▲ ▲ ✤ ✤ ✪ ✪ ✪ ✿ ✿

CHU de Lille - Hôpital Huriez ✪◆

CHU de Toulouse - Hôpital Rangueil ✪◆

CHU de Tours - Hôpital Bretonneau ✤ ✪ Hôpital Univeristaire Pitié-Salpêtrière ■ ■ ✪ Hospices Civils de Lyon ✪◆ Inserm Lyon ✤ ✖ ■✪✪ ✪ ✪ ◆ ◆ ✿ ✿ Institut Gustave Roussy ●✪

Region Miscellaneous Neurological ✪ Breast cancer Pediatrics Europe* ✖ Glaucoma ■ Brain cancer ✪ Kidney cancer ✱ Osteoid osteoma ✖ Soft tissue cancer ■ Brain tumors, benign ✪ ✱ Soft tissue tumors, benign Cardiovascular Liver cancer ✖ Soft tissue tumors, benign ■ Essential tremor ✪ Pancreatic cancer ✚ Hypertension Urological ■ Neuropathic pain ✪ Prostate cancer ✚ Peripheral artery disease Musculoskeletal ◆ Kidney cancer ■ Painful amputation stump ✪ ● Back pain, facetogenic Soft tissue cancer ◆ Kidney stones Endocrine Disorders neuromas ● Back pain, sacroiliitis ◆ Prostate cancer ▲ Thyroid nodules ■ Parkinson’s disease Pain ● Bone cancer ▼ Back pain, facetogenic Women’s Health Gastrointestinal ● Bone metastases Oncological ▼ Back pain, sacroiliitis ✿ Breast cancer ✤ Liver cancer ● Osteoarthritis ✪ Bone cancer ▼ Neuropathic pain ✿ Breast fibroadenoma ✤ Pancreatic cancer ● Osteoid osteoma ✪ Bone metastases ▼ Osteoid osteoma ✿ Uterine adenomyosis ✪ Brain cancer ▼ Painful amputation stump ✿ Uterine fibroids neuromas

Clinical research sites are any site treating patients as part of a clinical study. *Indications not being researched in a region have been removed from the key.

32 Focused Ultrasound Foundation | State of the Field 2017 Focused Ultrasound Foundation CLINICAL

Endrocrine Gastro- Women’s Cardiovascular Disorders intestinal Misc. Musculoskeletal Neurological Onocological Pain Peds Urological Health France continued Institut Mutualiste Montsouris ✪◆ University of Nice Sophia Antipolis ✪◆

Germany Amper Klinik ✖ ● ● ● ● ✪ ✪ ▼ ▼ ▼ ✱ ✿ ✿ Brustzentrum Marienhospital Bottrop ●✪✪✿✿ ✿ Charité Universitätsmedizin Berlin ●✪✪◆✿ Clemenshospital GmbH ✚ German Cancer Research Center ✪◆ Heidelberg German Heart Centre - Munich ✚ Klinikum Fürth ✪◆ Krankenhaus Nordwest ●▼ Sana CardioMed Nord ✚ Universitaeres Herzzentrum Hamburg ✚ GmbH Universitaetsklinikum Erlangen ✚ Universitätsklinikum Tübingen ✿ University Hospital Bonn ✚ ✤ ✤ ✪ ✪ University Hospital Frankfurt ▲ University Hospital of Cologne ✤ ✖ ● ● ✪ ✪ ✪ ✪ ✿ University Hospital of Leipzig ✚ ✚ University Hospital Schleswig-Holstein ✿ University of Munich ●✪ ✿ Urologische Universitätsklinik Magdeburg ✪◆

Israel Chaim Sheba Medical Center ●✪ ✿ Rambam Medical Center ■▼

Italy Azienda Ospedaliera San Paolo ✖ Careggi General Hospital ✤ ✤ ✖ ●✪✪ ✪ ✪ ✱ ◆ ✿ ✿ Cisanello Hospital of University of Pisa ✖ ● ✪ ✪ ▼ ✱ ✱ ◆ ✿ ✿ Clinica oculistica Università - ✖ Ospedale oftalmico European Institute of Oncology ✤ ✤ ✖ ● ● ✪ ✪ ✪ ✪ ▼ ✱ ✱ ✿ ✿ ✿

Clinical research sites are any site treating patients as part of a clinical study.

Focused Ultrasound Foundation | State of the Field 2017 33 CLINICAL

Endrocrine Gastro- Women’s Cardiovascular Disorders intestinal Misc. Musculoskeletal Neurological Onocological Pain Peds Urological Health Italy continued Istituto Ortopedico Rizzoli ✖ ✖ ● ● ● ● ■ ✪ ✪ ✪ ✪ ▼ ▼ ▼ ✱ ✱ ◆ ● ●▼ Laboratorio di Tecnologie Oncologiche ●✪ ✿ (LATO) HSR Giglio, Fondazione Istituto San Raffaele G. Giglio di Cefalu Niguarda Hospital ✿ ✿ Regina Apostolorum Albano ▲ St. Orsola-Malpighi Teaching Hospital ✖ Università degli Studi di Parma ✖ University Eye Clinic of Genoa ✖ University of L’Aquila ● ● ✪ ▼ ✱ ✿ ✿ University of Perugia ✪◆ University of Rome - La Sapienza ✤ ● ● ● ✪ ✪ ▼ ▼ ✱ ✿ ✿

Netherlands Radboud University Nijmegen Medical ✪◆ Centre University Medical Center Utrecht ✤ ●✪✪ ✪ ✪ ◆ ✿ ✿

Norway Haukeland University Hospital ✤ ✪ The Intervention Centre, Oslo University ✿ Hospital Rikshopitalet

Poland Szpital Pro-Familia ✿

Russia Medical Center of Central Bank of ✤ ✖ ● ✪ ✪ ✪ ▼ ✱ ✱ ◆ ✿ ✿ Russian Federation N. N. Petrov Research Institute of ●✪ ✿ Oncology National Medical Surgery Center ✤ ✖ ● ✪ ✪ ✪ ▼ ✱ ✱ ◆ ✿ ✿ Research Center for Obstetrics, Gynecology ✿ and Perinatology of Russian Ministry of Health and Social Development Rostov Scientific Research Institute ●✪ of Oncology

Clinical research sites are any site treating patients as part of a clinical study.

34 Focused Ultrasound Foundation | State of the Field 2017 Focused Ultrasound Foundation CLINICAL

Endrocrine Gastro- Women’s Spain Cardiovascular Disorders intestinal Misc. Musculoskeletal Neurological Onocological Pain Peds Urological Health

CINAC HM Puerta del Sur ■ Hospital Clínico San Carlos ✖ Hospital Universitari Mutua Terrassa ✤ ✪ Instituto Cartuja de Técnicas Avanzadas ✿ en Medicina ResoFus - Centre Medic Alomar ✪◆

Switzerland

FUS-Center, University of Zurich, ■ ■ ■ ■ ✪ ▼ Children’s Hospital Kantonsspital Aarau ■ ■ ✪ Kantonsspital Winterthur ✪✿✿ University Hospital Zurich ✪◆

United Kingdom Birmingham Heartlands Hospital ✚ Churchill Hospital ✤ ✤ ●✪✪ ✪ ✪ ◆ ✿ Southampton University Hospital ✚ St. Bartholomew’s Hospital ✚ St. Mary’s Hospital ✤ ■ ■ ✪ ✪ ✪ ◆ ◆ ✿ The Institute of Cancer Research ●✪ University Hospital of Wales ✚ University of Glasgow ✚ University of Hull ●✪✪✿

Clinical research sites are any site treating patients as part of a clinical study. *Indications not being researched in a region have been removed from the key. Focused Ultrasound Foundation | State of the Field 2017 35 CLINICAL

Asia 53 Sites by Region Endrocrine Gastro- Women’s China Cardiovascular Disorders intestinal Misc. Musculoskeletal Neurological Onocological Pain Peds Urological Health

307 Hospital of PLA ✤ ✖ ● ✪ ✪ ✪ ▼ ✱ ✱ ◆ ✿ ✿ Central Hosp. of Shanghai Xuhui District ✿ Children’s Hospital of Chongqing ✤ ✖ ● ✪ ✪ ✪ ▼ ✱ ✱ ◆ ✿ ✿ Medical University Chinese University of Hong Kong ✿ Chongqing Medical University ✖ ✿ ✿ First Affiliated Hospital of Medical ●✪ ✿ College of Xi’an Jiaotong University First Affiliated Hospital of Shihezi Univ. ✤ ✪ First Affiliated Hospital of Zunyi ✤ ✖ ● ✪ ✪ ▼ ✱ ✱ ◆ ✿ ✿ Medical College First Maternal and Child Health Hospital ✤ ✖ ● ✪ ✪ ✪ ▼ ✱ ✱ ◆ ✿ ✿ of Shanghai Fundan University Huashan Hospital ●✪ ✿ Fundan University Shanghai Cancer ✿ Center

HAIFU Hospital ✤ ✖ ● ✪ ✪ ✪ ▼ ✱ ✱ ◆ ✿ ✿ Henan University Huaihe Hospital ✿ Institute of Ultrasonic Engineering in ✚ ✤ ✖ ● ✪ ✪ ✪ ▼ ✱ ✱ ◆ ✿ ✿ Medicine and Clinical Centre for Tumour Therapy Peking Union Hospital, Chinese ✿ Academy of Medical Sciences

Region Cardiovascular Musculoskeletal Oncological Pediatrics Asia* ✚ Hypertension ● Back pain, facetogenic ✪ Bone cancer ✱ Osteoid osteoma ● Back pain, sacroiliitis ✪ Bone metastases ✱ Soft tissue tumors, benign Endocrine Disorders ● ✪ ▲ Thyroid cancer Bone cancer Brain cancer Urological ● Bone metastases ✪ Breast cancer ▲ Thyroid nodules ◆ Benign prostatic hyperplasia ● Osteoarthritis ✪ Kidney cancer ◆ Kidney cancer Gastrointestinal ● Osteoid osteoma ✪ Liver cancer ◆ Kidney stones ✤ Liver cancer ✪ Pancreatic cancer ✤ Neurological ◆ Prostate cancer Malignant obstructive ✪ Prostate cancer ■ Brain cancer jaundice ✪ Thyroid cancer Women’s Health ■ Depression ✤ Pancreatic cancer ✿ Breast cancer ■ Essential tremor Pain ✿ Breast fibroadenoma Miscellaneous ■ Obsessive-compulsive ▼ Back pain, facetogenic ✖ ✿ Tubal pregnancy Hypersplenism disorder ▼ Back pain, sacroiliitis ✖ ✿ Uterine adenomyosis Soft tissue tumors, benign ■ Parkinson’s disease ▼ Osteoid osteoma ✿ Uterine fibroids

Clinical research sites are any site treating patients as part of a clinical study. *Indications not being researched in a region have been removed from the key.

36 Focused Ultrasound Foundation | State of the Field 2017 Focused Ultrasound Foundation CLINICAL

Endrocrine Gastro- Women’s Cardiovascular Disorders intestinal Misc. Musculoskeletal Neurological Onocological Pain Peds Urological Health China continued Peking University First Hospital ✿

PLA 301 Hospital (General Hospital of ✤ ✖ ● ✪ ✪ ✪ ▼ ✱ ✱ ◆ ✿ ✿ the People’s Liberation Army) Queen Mary Hospital of the University ▲ ▲ ✤ ✖ ● ✪ ✪ ✪ ✪ ▼ ✱ ✱ ◆ ✿ ✿ of Hong Kong Shanghai Jiaotong University ●✪ Suining Central Hospital ✤ ✖ ● ✪ ✪ ✪ ▼ ✱ ✱ ◆ ✿ ✿ The First Affiliated Hospital of ✤ ✖ ● ✪ ✪ ✪ ▼ ✱ ✱ ◆ ✿ ✿ Chongqing Medical University The First People’s Hospital of ✿ Shijiazhuang The Second Affiliated Hospital of ✤ ✖ ✪ ✱ Zhejiang University The Second Artillery General Hospital ✤ ✤ ✖ ● ✪ ✪ ✪ ✪ ▼ ✱ ✱ ◆ ✿ ✿ of Chinese PLA The Third Xiangya Hospital of Central ✤ ✖ ● ✪ ✪ ✪ ▼ ✱ ✱ ◆ ✿ ✿ South University Xijing Hospital of The Fourth Military ✿ Medical University Xuzhou Central Hospital ✤ Zhabei District Central Hospital ✪✿

India Apollo Specialty Hospital, Chennai ✿

GSL Medical College ✿ Jaslok Hospital and Research Centre ● ✪ ▼ ◆

Japan Breastopia Namba Hospital ●✪ ✿ Hokuto Hospital ■ ■ ✪✿✿ Kochi University Hospital ● ● ▼ Osaka University ■ Shinsuma General Hospital ✿ ✿ Takanobashi Central Hospital ✪◆ Teikyo University ✪◆ Tokai University ✪◆ Tokyo Medical University ✤ ✪ Washokai Sadamoto Hospital ■

Clinical research sites are any site treating patients as part of a clinical study.

Focused Ultrasound Foundation | State of the Field 2017 37 CLINICAL

Endrocrine Gastro- Women’s Kazakhstan Cardiovascular Disorders intestinal Misc. Musculoskeletal Neurological Onocological Pain Peds Urological Health National Medical Research Center ✤ ✖ ● ✪ ✪ ✪ ▼ ✱ ✱ ◆ ✿ ✿

Malaysia University of Malaya ✚ ✤ ✤ ✖ ● ● ✪ ✪ ✪ ✪ ▼ ✱ ✱ ◆ ✿ ✿ ✿

Republic of Korea

CHA Bundang Medical Center ✿ ✿ Chaum Hospital ✿ ✿

MINT Intervention Hospital ✿ ✿ The Catholic University of Korea ✿ ✿

YUMC Gangnam Severance Hospital ●✪✪◆✿

YUMC Severance Hospital ■ ■ ■

Singapore Nanyang Technological University ✚ ✤ ✤ ✪ ✪ ✪ ✪ ◆ ◆ ◆ ✿ ✿ ✿ ✪◆

Taiwan Chang Gung University ■✪ National Defense Medical Center ✪◆ Taipei Medical University Hospital ●✪✪◆✿

Oceania 3 Sites by Region Endrocrine Gastro- Women’s Australia Cardiovascular Disorders intestinal Misc. Musculoskeletal Neurological Onocological Pain Peds Urological Health Future Medical Imaging Group ✖ ✖ ● ● ● ● ✪ ✪ ▼ ▼ ▼ ✱ ✱ ✿ ✿ ● Royal Women’s Hospital Melbourne ●✪ ✿ ✿

New Zealand Mercy Angiography ✚

Region Cardiovascular Musculoskeletal Oncological Pediatrics Oceania* ✚ Peripheral artey disease ● Back pain, facetogenic ✪ Bone metastases ✱ Osteoid osteoma ● Back pain, sacroiliitis ✪ Soft tissue cancer ✱ Soft tissue tumors, benign Miscellaneous ● ✖ Soft tissue cancer Bone metastases Pain Women’s Health ● Osteoarthritis ✖ Soft tissue tumors, benign ▼ Back pain, facetogenic ✿ Uterine adenomyosis ● Osteoid osteoma ▼ Neuropathic pain ✿ Uterine fibroids ▼ Osteoid osteoma Clinical research sites are any site treating patients as part of a clinical study. *Indications not being researched in a region have been removed from the key.

38 Focused Ultrasound Foundation | State of the Field 2017 COMMERCIAL TREATMENT

Commercial Treatment Sites by Indications and Regions

North America Europe Asia ▼ ◆ 2 Back pain, facetogenic ◆ 27 Benign prostatic 33 Benign prostatic ◆ hyperplasia 10 Benign prostatic hyperplasia ●✪ hyperplasia ●✪ 3 Bone metastases 6 Bone metastases ●✪ ✿✪ 15 Bone metastases ✿✪90 Breast cancer 1 Breast cancer ✿✪ ■ 14 Breast cancer ✿ 3 Breast fibroadenoma 7 Essential tremor ✿ ◆✪ 14w Breast fibroadenoma ■ 4 Essential tremor 1 Kidney cancer ■ ✤✪ 7 Essential tremor ◆✪ 89 Kidney cancer 1 Liver cancer ✖ ●▼✱ 17 Glaucoma ✤✪ 90 Liver cancer 2 Osteoid osteoma ◆✪ ◆✪ 13 Kidney cancer ●▼✱ 89 Osteoid osteoma 46 Prostate cancer ✤✪ ✖ 14 Liver cancer ✤✪ 2 Pancreatic cancer 1 Soft tissue tumors, ■▼ benign 3 Neuropathic pain ■ 1 Parkinson’s disease ●▼✱ ✿ 15 Uterine fibroids 13 Osteoid osteoma ◆✪31 Prostate cancer ✤✪ 2 Pancreatic cancer ✖ 90 Soft tissue tumors, ■ 6 Parkinson’s disease benign ◆✪180 Prostate cancer ✖✪ 90 Soft tissue cancer ✖ 13 Soft tissue tumors, ▲ 3 Thyroid nodules benign ✿ 54 Uterine adenomyosis ✖✪ 13 Soft tissue cancer ✿ 177 Uterine fibroids ▲ 11 Thyroid nodules ■ 1 Trigeminal neuralgia ✿ 2 Uterine adenomyosis ✿ 48 Uterine fibroids

South America Africa Oceania ◆ 1 Benign prostatic ✿ 1 Breast fibroadenoma ✿ 2 Uterine fibroids hyperplasia ◆✪ 2 Prostate cancer ◆✪ 9 Prostate cancer ▲ 1 Thyroid nodules ✿ 1 Uterine fibroids

Commercial treatment sites provide treatment with a focused ultrasound system for a regulatory approved indication.

Focused Ultrasound Foundation | State of the Field 2017 39 COMMERCIAL TREATMENT

Commercial Treatment Sites by Country

Commercial treatment sites provide treatment with a focused ultrasound system for a regulatory approved indication. ■ North America ■ Europe 29 Russia ■ Asia ■ Oceania 8 Spain 1 Bahamas 5 Austria 2 Sweden 134 China 2 Australia 9 Canada 2 Belgium 8 India 14 Switzerland ■ 1 Costa Rica 1 Bulgaria 1Turkey 1 Iran Africa 1Cuba 1 Denmark 1 Ukraine 40 Japan 2 Egypt 2 Dominican Republic 70 France 15 United Kingdom 1 Kazakhstan 1 Morocco 1 Grand Cayman 55 Germany 2 Kingdom of 4 Mexico 5 Israel Saudi Arabia 1 Trinidad and Tobago 44 Italy 1 Lebanon 46 United States 1 Monaco 1 Malaysia 2 The Netherlands 1 Myanmar ■ South America 2 Norway 1 Qatar 4 Poland 21 Republic of Korea 1 Argentina 2 Romania 1 Singapore 1 Bolivia 18 Taiwan 4 Brazil 2 Thailand 1 Chile 1 United Arab Emirates 3 Ecuador 1 Uzbekistan 2 Vietnam

40 Focused Ultrasound Foundation | State of the Field 2017 COMMERCIAL TREATMENT

112 new commercial treatment sites were added in 2016.

Commercial treatment 582 sites worldwide 66 265 236 North America Europe Asia 10 3 2 South America Africa Oceania

Commercial treatment sites provide treatment with a focused ultrasound system for a regulatory approved indication.

Master key all regions 21 indications are being treated commercially at sites worldwide.

Endocrine Disorders Musculoskeletal Oncological Pain Women’s Health ▲ Thyroid nodules ● Bone metastases ✪ Bone metastases ▼ Back pain, facetogenic ✿ Breast cancer ● Osteoid osteoma ✪ Breast cancer ▼ Neuropathic pain ✿ Breast fibroadenoma Gastrointestinal ✪ Kidney cancer ▼ Osteoid osteoma ✿ Uterine adenomyosis ✤ Liver cancer Neurological ✪ Liver cancer ✿ Uterine fibroids ✤ Pancreatic cancer ■ Essential tremor ✪ Pancreatic cancer Pediatrics ■ Neuropathic pain ✪ Prostate cancer ✱ Osteoid osteoma Miscellaneous ■ Parkinson’s disease ✪ ✖ Soft tissue cancer Glaucoma ■ Trigeminal neuralgia Urological ✖ Soft tissue cancer ◆ Benign prostatic hyperplasia ✖ Soft tissue tumors, benign ◆ Kidney cancer ◆ Prostate cancer

Focused Ultrasound Foundation | State of the Field 2017 41 COMMERCIAL TREATMENT

Commercial Treatment Sites by Region

Bahamas Trinidad and Tobago ◆✪ Doctors Hospital ◆ ◆✪ Trinidad Urology Center

Canada United States 66 ◆ ◆✪ Can-Am HIFU ◆ ◆✪ Alamance Urological North America ◆ ◆✪ Cleveland Clinic Canada ◆ ◆✪ Associated Urology of North Carolina ◆✪ Don Mills Surgical Unit ■ ✿ Brigham and Women’s Hospital ◆✪ Jewish General Hospital ◆ ◆✪ California HIFU ◆✪ Les Cours Medical Centre ◆ ◆✪ Carolina Urology Partners ◆ ◆✪ London Health Sciences Centre ●✪ City of Hope ✿ Sunnybrook Health Sciences Centre ◆ ◆✪ Comprehensive Urology ✿ Thunder Bay Regional Research Institute ✿ Duke Health Center at Southpoint ◆✪ University of Western Ontario ◆ ◆✪ Encino HIFU ◆ ◆✪ First Urology Costa Rica ●✪ Fox Chase Cancer Center ◆✪ Hospital CIMA San Jose ◆ ◆✪ Health Orlando Cuba ◆ ◆✪ Houston Premier Urology ✤ ✪ ✖✪● Hospital Medical Surgical Research ◆ ◆✪ Indiana University School of Medicine ▼ ◆ ✪✿✪ Center (CIMEQ) ◆ ◆✪ Kar Urology ✿ ✿ Mayo Clinic - Minnesota ●✪ Dominican Republic Medical College of Wisconsin Froedtert Hospital ◆✪ CEDIMAT ◆ ◆✪ New York Methodist Hospital ◆✪ Clinica Union Medica ◆ ◆✪ New York University - Grand Cayman Langone Medical Center ◆ ◆✪ ◆✪ Chrissie Tomlinson Hospital Northern Litho ■ Ohio State University Mexico ◆ ◆✪ Piedmont Healthcare Urology ◆✪ Centro Médico Puerta de Hierro ◆ ◆✪ Prostate Cancer Institue ◆✪ Hospital Galenia ✿ Riverside Methodist Hospital ✿ Medica Sur Tlalpan ◆ ◆✪ Riverside Urology ◆✪ San Javier Hospital Marina ◆ ◆✪ San Fernando Valley Urology Associates

In this Region Miscellaneous Neurological ✪ Prostate cancer Urological North America* ✖ Soft tissue cancer ■ Essential tremor ✪ Soft tissue cancer ◆ Benign prostatic hyperplasia ✖ Soft tissue tumors, benign ◆ Kidney cancer Gastrointestinal Oncological Pain ✪ ◆ Prostate cancer ✤ Liver cancer Musculoskeletal Bone metastases ▼ Osteoid osteoma ● Bone metastases ✪ Breast cancer Women’s Health ● Osteoid osteoma ✪ Kidney cancer ✿ Breast cancer ✪ Liver cancer ✿ Uterine fibroids

Commercial treatment sites provide treatment with a focused ultrasound system for a regulatory approved indication. *Indications not being researched in a region have been removed from the key.

42 Focused Ultrasound Foundation | State of the Field 2017 COMMERCIAL TREATMENT

Commercial Treatment Sites by Region

◆ ◆✪ Sarasota Prostate Care ●✪✿ University of California San Francisco ◆ ◆✪ Scionti Prostate Center ■ University of Maryland School ◆ ◆✪ Skyline Urology of Medicine ◆ ◆✪ ●✪●▼ ■ Stanford University Medical Center University of Miami Hospital ◆✪✿ ◆ ◆✪ University of Southern California ■ Swedish Neurosciences Institute Keck Hospital ●✪■ ✿ ◆ ◆✪ Texas HIFU Partners University of Virginia Health System ◆ ◆✪ ✿ University MRI & Diagnostic Imaging Urology Center of Winter Park Centers - South ◆ ◆✪ Urology of Mount Dora ✿ University of California Los Angeles ◆ ◆✪ Urology Specialists of the Carolinas ✿ University of California San Diego ◆ ◆✪ Virginia HIFU Thornton Hospital ■ ✿ Weill Cornell Medical Center ◆ ◆✪ Western States HIFU

In this Region Miscellaneous Neurological ✪ Liver cancer Urological North America* ✖ Soft tissue cancer ■ Essential tremor ✪ Prostate cancer ◆ Benign prostatic hyperplasia ✖ Soft tissue tumors, benign ✪ Soft tissue cancer ◆ Kidney cancer Gastrointestinal Oncological ✪ ◆ Prostate cancer ✤ Liver cancer Musculoskeletal Bone metastases Pain ● Bone metastases ✪ Breast cancer ▼ Osteoid osteoma Women’s Health ● Osteoid osteoma ✪ Kidney cancer ✿ Breast cancer ✿ Uterine fibroids

Argentina Chile ◆✪ Centro de Urologia ◆✪ Clinica Santa María

Bolivia Ecuador 10 ◆✪ Centro de urología avanzada ◆✪ Hospital Carlos Andrade Marìn South America de la Clínica Incor ◆✪ Hospital IESS ◆✪ Hospital Policia Nacional Guayaqui Brazil ◆✪ Centro de Prostata San Paulo ◆✪ Hospital AC Camargo de São Paulo ◆ ◆✪ Hospital Nossa Senhora das Gracas ✿ Instituto do Cancer do Estado de Sao Paulo (ICESP)

In this region Oncological Women’s Health South America* ✪ Prostate cancer ✿ Uterine fibroids Urological ◆ Benign prostatic hyperplasia ◆ Prostate cancer

Commercial treatment sites provide treatment with a focused ultrasound system for a regulatory approved indication. *Indications not being researched in a region have been removed from the key.

Focused Ultrasound Foundation | State of the Field 2017 43 COMMERCIAL TREATMENT

Commercial Treatment Sites by Region

Austria ◆✪ CHU de Nice - Hôpital Pasteur ◆✪ Allgemeines Krankenhaus der Stadt Wien ◆✪ CHU de Reims - Hôpital Robert Debré ✿ Barmherzige Brueder ◆✪ CHU de Rouen - Hôpital Charles Nicolle ✿ Krankenhaus der Barmherzigen ◆✪ CHU de Strasbourg - Hôpital Civil Brüder Wien 265 ◆✪ CHU de Toulouse - Hôpital Rangueil ◆✪ TILAK Unternehmen Gesundheit Europe ✿ CHU de Tours - Hôpital Bretonneau ●✪✿ University of Vienna ✖ CHU Lapeyronie Belgium ◆✪ Clinique Adassa ◆✪ Algemeen Ziekenhuis Middelheim ✖ Clinique Aguilera ◆✪ Institut Jules Bordet ◆✪ Clinique Belledonne ◆✪ Clinique Beau Soleil Bulgaria ◆✪ Clinique Chirurgicale du Pre ✤ ✪✤ ✪ ✖ Saint Marina Hospital ✪ ✖ ●▼ ◆ ◆✪ Clinique Clément Devron ✪✿✪✿ ✿ ◆✪ Clinique de l’Union ◆✪ Clinique du Palais Denmark ◆✪ Clinique du Val d’Ouest ●✪✿ Aarhus University Hospital ✖ Clinique François Chénieux France ✖ Clinique Juge ✿ American Hospital of Paris ✖ Clinique Mathilde ◆✪ Centre Hospitalier de Chambéry ✖ Clinique Pasteur ◆✪ Centre Hospitalier de Saintonge ◆✪ Clinique Saint Augustin ◆✪ Centre Hospitalier du Pays d’Aix ◆✪ Clinique Saint Etienne - Bayonne ◆✪ Centre Hospitalier Nord de Marseille - CHU ◆✪ Clinique Saint Jean de Dieu ◆✪ Centre Hospitalier Universitaire de Caen ◆✪ Clinique Saint Jean du Languedoc ◆✪ CHU de Bordeaux - Hôpital du Tondu ◆✪ Clinique Saint Jean - Montpellier ✿ CHU de Bordeaux - Hôpital Saint-André ◆✪ Clinique Saint-Michel ◆✪ CHU de Guadeloupe - Hôpital les Abymes ✖ Clinique Saint Nicolas ◆✪ CHU de Pontoise - Hôpital René Dubos ◆✪ Clinique Saint Vincent ◆✪✿ CHU de Lille - Hôpital Huriez ◆✪ Clinique Sainte Clotilde - La Réunion ◆✪ CHU de Limoges - Hôpital Dupuytren ✖ Clinique Sourdille

In this region Miscellaneous Neurological ✪ Liver cancer Urological Europe* ✖ Glaucoma ■ Essential tremor ✪ Pancreatic cancer ◆ Benign prostatic hyperplasia ✖ Soft tissue cancer ■ Neuropathic pain ✪ Prostate cancer ◆ Kidney cancer Endocrine Disorders ✖ ■ ◆ ▲ Soft tissue tumors, benign Parkinson’s disease ✪ Soft tissue cancer Prostate cancer Thyroid nodules ■ Musculoskeletal Trigeminal neuralgia Women’s Health Gastrointestinal Pain ● Bone metastases Oncological ▼ Back pain, facetogenic ✿ Breast cancer ✤ Liver cancer ● Osteoid osteoma ✪ Bone metastases ▼ Neuropathic pain ✿ Breast fibroadenoma ✤ Pancreatic cancer ✪ Breast cancer ▼ Osteoid osteoma ✿ Uterine adenomyosis ✪ Kidney cancer ✿ Uterine fibroids

Commercial treatment sites provide treatment with a focused ultrasound system for a regulatory approved indication. *Indications not being researched in a region have been removed from the key.

44 Focused Ultrasound Foundation | State of the Field 2017 COMMERCIAL TREATMENT

Commercial Treatment Sites by Region

◆✪ Clinique urologique Nantes Atlantis Germany ◆✪ Clinique Villette ◆✪ Agaplesion Diakonieklinikum Hamburg ✖ ◆✪ Fondation Hôpital Saint-Joseph - Marseille ✿ Amper Klinik ✿ Groupe Hospitalier Diaconesses Croix ◆✪ Asklepios Klinik Barmbek Saint-Simon ◆✪ Asklepios Kliniken Weißenfels- ◆✪ Groupe Hospitalier Prive Saint Hohenmölsen GmbH Joseph-Paris ◆✪ Asklepios Paulinen Klinik ✖ Hôpital A. Michallon ▲ ✿ Borad Zentrale Bottrop ✖ Hôpital Bégin ▲ ✿ Bremen Zentrum fur Nuklearmedizin ✖ Hôpital Claude Huriez und PET/CT ◆✪ Hôpital Clinique Claude Bernard - Metz ▲✿ ✿ Brustzentrum Marienhospital Bottrop ✖ Hôpital de la Croix-Rousse ▲ ✿ Buergerhospital Frankfurt ✖ Hôpital des Quinze-Vingts ◆✪✿ Charité Universitätsmedizin Berlin ◆✪ Hôpital Edouard Herriot ✿ Diagnoseklinik Stephansplatz ◆✪ Hôpital Foch ◆✪ Diakonie-Klinikum Stuttgart ▲ ◆✪ Hôpital Universitaire Pitié-Salpêtrière ◆✪ Ev. Krankenhaus Göttingen-Weende e.V. ◆✪ Hôpital privé La Louvière ◆✪ Franziskus-Krankenhaus ◆✪ Hôpitaux Civils de Colmar Hôpital Pasteur ◆✪ Gemeinschaftspraxis für Urologie ▲ ✿ Institut de Radiologie de Paris Mannheim ◆✪ ◆✪ Institut Mutualiste Montsouris GPR Gesundheits-und Pfegezentrum ◆✪ Russelsheim gGmbH-Klinikum Pôle Santé Léonard de Vinci ◆✪ ◆✪ Heilig-Geist Hospital Pôle Santé République ▲ ✿ ◆✪ HELIOS Klinik Schkeuditz Polyclinique Bordeaux Nord Aquitaine ◆✪ ✖ Isarklinikum Polyclinique Côte Basque Sud ◆✪ ◆✪ Klinik für Prostata-Therapie GmbH Polyclinique du Parc Rambot ◆✪ ✿ Klinik und Poliklinik für Urologie der Polyclinique Jean Villar Universitaet Regensburg am ◆✪ Polyclinique Kenval Caritaskrankenhaus St. Josef ◆✪ Polyclinique Montréal ◆✪ Klinikum Fürth ◆✪ Polyclinique Ormeaux République ◆✪ Klinikum Itzehoe ◆✪ Polyclinique Vauban ◆✪ Klinikum Landshut gGmbH

Commercial treatment sites provide treatment with a focused ultrasound system for a regulatory approved indication. *Indications not being researched in a region have been removed from the key.

Focused Ultrasound Foundation | State of the Field 2017 45 COMMERCIAL TREATMENT

Commercial Treatment Sites by Region

◆✪ Klinikum Nürnberg ◆✪ Urologisches Zentrum Neustadt ◆✪ Klinikum Region Hannover - Gehrden ●✪ Zentralklinik Bad Berka ◆✪ Krankenhaus Dresden-Friedrichstadt Israel ▼ ◆✪ Krankenhaus Nordwest ■ ●✪✿ Chaim Sheba Medical Center ◆✪ KRH Klinikum Grossburgwedel ◆ ◆✪ Israel HIFU Ltd. ✿ Marienhospital Stuttgart ◆ ◆✪ Normed ◆✪ Missionsärztliche Klinik gGmbH ◆ ◆✪ Ramat Aviv ◆✪ Paracelsus Klinik Reichenbach GmbH ■ ■ Rambam Medical Center ▲ Praxis für Nuklearmedizin Paderborn ◆✪ Praxis für Urologie Mannheim Italy ✿ Radiologische Gemeinschaftspraxis ◆✪ Alliance Medical, Italy ◆✪ Sankt Katharinen Krankenhaus ◆ ◆✪ Arco dell’Angelo ◆✪ St. Antonius-Hospital ◆✪ Azienda Ospedaliera A. Cardarelli ◆✪ St. Barbara Hospital ◆✪ Azienda Ospedaliera ‘Di Venere - ◆✪ St. Elisabeth-Krankenhaus Köln-Hohenlind Giovanni XXIII‘ ◆✪ ◆✪ St. Elisabeth-Krankenhaus Leipzig Azienda Ospedaliera S. Maria degli Angeli ◆✪ ◆✪ St. Josefs Hospital GmbH Azienda Ospedaliera Universitaria di Parma ◆✪ ◆✪ Staedtisches Klinikum München Azienda Ospedaliera Universitaria Tor Vergata ◆✪ Theresienkrankenhaus Mannheim ◆✪ Azienda USL 1 Massa E Carrara ◆✪ Universitaetsmedizin Mannheim ✤ ✪ ✖✪✖ Careggi General Hospital ◆✪ Universitäres Herzzentrum Hamburg GmbH ●▼◆ ✪ ✪ ◆✪ Universitätsklinikum Aachen ✿✪✿ ◆✪●✪✿ University Hospital of Cologne ◆✪✿ Casa di Cura Abano Terme ◆✪ University Hospital of Leipzig ◆✪ Casa di Cura Columbus ✿ University Medical Center Lubeck ◆✪ Casa di Cura Rugani ✿ University of Munich ✤ ✪ ✖✪✖ Cisanello Hospital of University of Pisa ◆✪ Urologie Oberkassel ●▼◆ ✪ ✪ ✿✪✿ ◆✪ Urologische Universitätsklinik Magdeburg ●✪ ◆✪ Urologische Universitätsklinik Heidelberg CROB IRCCS Rionero

Commercial treatment sites provide treatment with a focused ultrasound system for a regulatory approved indication. *Indications not being researched in a region have been removed from the key.

46 Focused Ultrasound Foundation | State of the Field 2017 COMMERCIAL TREATMENT

Commercial Treatment Sites by Region

●▼◆ ✪ ✖ European Institute of Oncology ◆✪ Spedali Civili de Brescia ✪✤ ✖ ✪ ✿ ✖ St. Orsola-Malpighi Teaching Hospital ✪ ✿ ✖ University Eye Clinic of Genoa ✿ Foligno Hospital ✿ University of L’Aquila ◆✪ INI Divisione Canistro ■ ■ University of Palermo ◆✪ INI Divisione Grottaferrata ◆✪ University of Perugia ◆✪ Instituto Nazionale di Riposo ✿ University of Rome - La Sapienza e Cura per Anziani ●✪ Istituto Oncologico Romagnolo Monaco ●✪✿ Laboratorio di Tecnologie Oncologiche ◆✪ Centre Hospitalier Grace de Monaco (LATO) HSR Giglio, Fondazione Istituto San Raffaele G. Giglio di Cefalu The Netherlands ✿ Niguarda Hospital ◆✪ Hifu Klinik Nederland - Bergen op Zoom ◆✪ Nuova Villa Claudia ✿ University Medical Center Utrech ◆✪ Ospedale Cardinal Massaia di Asti Norway ◆✪ Ospedale di Nocera Inferiore Umberto I ◆✪ Aker University Hospital ◆✪ Ospedale Evangelico Internazionale ✿ The Intervention Centre, Oslo University ◆✪ Ospedale Misericordia e Dolce di Prato Hospital Rikshopitalet ◆✪ Ospedale Ramazzini di Carpi Poland ◆✪ Ospedale San Bartolomeo di Sarzana ◆✪ ESKULAP Hospital ◆✪ Ospedale San Giovanni Bosco ◆ ◆✪ Europerjskie Centrum Zdrowa Otwock ◆✪ Ospedale San Raffaele Giglio di Cefalu ◆✪ HIFU Clinic Warsaw ◆✪ Ospedale Sant' Anna di Como ✿ Szpital Pro-Familia ◆✪ P.O. di Castellanza ◆✪ P.O. di Este Romania ◆✪ Policlinico Gemelli ◆✪ DTL Medica ✤ ✪ ✖✪● Rome American Hospital ✤ ✪ ✖✪● HIFU Terramed Conformal Centre ▼ ◆ ✪ ✪ ✿ ▼ ◆ ✪ ✪ ✿ ✪ ✿ ✪ ✿ ✤ ✪ ✖✪● Sora Cancer Centre ▼ ◆ ✪ ✪ ✿ ✪ ✿

Commercial treatment sites provide treatment with a focused ultrasound system for a regulatory approved indication. *Indications not being researched in a region have been removed from the key.

Focused Ultrasound Foundation | State of the Field 2017 47 COMMERCIAL TREATMENT

Commercial Treatment Sites by Region

Russia ◆✪ Regional Oncology Dispensary of Tyumen ✿ Center of Family Planning & Reproduction ✿ Research Center for Obstetrics, Gynecology (CFPR) and Perinatology of Russian Ministry of ✤ ✪ ✖✪● Central Institute of Traumatology and Health and Social Development ▼ ◆ ✪ ✪ ✿ Orthopedics ●✪ Rostov Scientific Research Institute ✪ ✿ of Oncology ◆✪ City Hospital No. 2 ◆✪ Russian Railways (RZD) Hospital ◆✪ Clinical Diagnostis Center Zdorovie ◆✪ Samara Oncoly Centre ◆✪ Ekaterinburg Regional Hospital N1/Ural ◆✪ Saratov City Medical Academy Medical University, Central Ural Region ◆✪ Sberbank Central Medical Center ◆✪ Far Eastern Federal University ◆✪ St. Petersburg Oncology Dispanser ◆✪ Gazprom Medical Centre, Omsk West ◆✪ The I.M. Sechenov Moscow Medical Siberia Region Academy (MMA) ◆✪ Hospital of Veterans of War ◆✪ Ufa Oncology Center ◆✪ Khanty-Mansiysk Regional Hospital North Siberia Spain ◆✪ Main Military Clinical Burdenko’s Hospital ■ ■ CINAC HM Puerta del Sur ✤ ✪ ✖✪● Medical Center of Central Bank of ✤ ✪✤ ✪ ◆ Clínica Santa Elena ▼ ◆ ✪ ✪ ✿ Russian Federation ✪✿ ✿ ✪ ✿ ◆✪ Clínica Virgen Blanca S.A. ◆✪ Military Medical Academy St. Petersburg ✤ ✪ ✖✪● Hospital Universitari Mutua Terrassa ◆✪ Moscow City Clinical Hospital Botkin ▼ ◆ ✪ ✪ ✿ ✪ ✿ ◆✪ Moscow Regional Research and Clinical Institute ◆ ◆✪ IMEX ◆✪ Moscow Roszdrav Medical Center ●✪✿ Instituto Cartuja de Técnicas Avanzadas ✤ ✪ ✖✪● National Medical Surgery Center en Medicina ▼ ◆ ✪ ✪ ✿ ◆✪ Policlínica San Antonio ✪ ✿ ■ ■✿ ●✪ ResoFus - Centre Medic Alomar ◆✪ NII of Urology ▼ ✿ ●✪ N. N. Petrov Research Institute of Oncology ◆✪ Orenbourg Oncology Center

Commercial treatment sites provide treatment with a focused ultrasound system for a regulatory approved indication. *Indications not being researched in a region have been removed from the key.

48 Focused Ultrasound Foundation | State of the Field 2017 COMMERCIAL TREATMENT

Commercial Treatment Sites by Region

Sweden United Kingdom ●✪✿ Karolinska University Hospital ◆✪ Basingstoke and North Hampshire Hospital ✿ Uppsala University Hospital ◆✪ BMI The Hampshire Clinic ◆✪ Candover Suite Basingstoke Switzerland ✤ ✪ ✖✪● Churchill Hospital ■ ■▼■ ■ Center for Ultrasound Functional ▼ ◆ ✪ ✪ ✿ Neurosurgery ✪ ✿ ◆✪ CHU de Genêve ●✪ King’s College Hospital ◆✪ CHUV de Lausanne ▲ ✿ London Breast Clinic ●✪✿ Clinique de Montchoisi ◆✪ Nuada Medical ◆✪ Clinique Generale Beaulieu ◆✪ Princess Grace Hospital ▲ ✿ EOC - Ospedale Regionale di Bellinzona ◆✪ Spire Parkway Hospital e Valli ✿ St. Mary’s Hospital ■ ■▼ ■ FUS-Center, University of Zurich, ◆ ◆✪ Children’s Hospital The Cromwell Hospital ●✪ ◆✪ Geneva University Hospital The Institute of Cancer Research ◆✪ ◆✪ Hopital de Nyon The Priory Hospital ◆✪ ◆ ◆✪ Inselspital - Universitaetsspital Bern The Winterbourne Hospital ◆✪ ◆ ◆✪ Kantonsspital Baden University College London Hospitals ✿✪✿ Kantonsspital Winterthur ◆ ◆✪ Klinik Hirslanden ◆✪ University Hospital Zurich Turkey ▲ ✿ Penta Elektronik Medikal Sistemler Ankara Ukraine ✤ ✪ ✖✪● Kiev City Oncology Hospital ▼ ◆ ✪ ✪ ✿ ✪ ✿

Commercial treatment sites provide treatment with a focused ultrasound system for a regulatory approved indication. *Indications not being researched in a region have been removed from the key.

Focused Ultrasound Foundation | State of the Field 2017 49 COMMERCIAL TREATMENT

Commercial Treatment Sites by Region

China Hubei Maternal and Child Health Hospital Institute of Ultrasonic Engineering in Medicine and ✤ ✪ ✖✪✖ Commerial treatment centers Clinical Centre for Tumour Therapy ●▼◆ ✪ ✿ for six indications Jiangmen Wuyi Traditional Chinese Medicine Hospital ✪ ✿ 236 Jiangsu Armed Police Corps Hospital Asia 307 Hospital of PLA Jiangsu Cancer Hospital Affiliated Hospital of Armed Police’s Medical College Jilin Center Hospital Affiliated Hospital of Chuanbei Medical College Jiugang Hospital Affiliated Hospital of Qinghai Medical College Jiujiang Maternal and Child Health Hospital Affiliated Hospital of Xinxiang Medical College Jixi People’s Hospital Baoji Maternal and Child Health Hospital Kaixian People’s Hospital Beijing Cancer Hospital Lianyungang Orient Hospital Beijing Hospital Liaoning Fushun Cancer Hospital Chengdu Shuangnan Hospital Luoyang Center Hospital Children’s Hospital of Chongqing Medical University Maternal and Child Health Hospital of Yubei District Chongqing Three Gorges Central Hospital Nanshi Hospital City Hospital of Bincheng District in Binzhou City No. 91 Central Hospital of the People’s Liberation Army Dalian Friendship Hospital Nong Ken Hospital Daxian People’s Hospital Obstetric Hospital of Changchun Dengfeng People’s Hospital People’s Hospital of Hunan Province Fifth People’s Hospital of Nanchong City People’s Hospital of Nanchuan District First Affiliated Hospital of Guangxi Medical University People’s Hospital of Xingtai First Affiliated Hospital of Kunming Medical University PLA 301 Hospital (General Hospital of the People’s First Maternal and Child Health Hospital of Shanghai Liberation Army) Fujian Provincial Hospital Shaanxi Maternal and Child Health Hospital Fuling Center Hospital of Chongqing Shandong Cancer Hospital Fundan University Shanghai Cancer Center Shandong Guangrao Traditional Chinese Medicine Hospital Guangzhou First Municipal People’s Hospital Shandong Qianfoshan Hospital Guantao People’s Hospital of Hebei Shanxi Traditional Chinese Medicine Hospital Haifu Hospital Shenzhen Maternal and Child Health Center Hospital Haifu Hospital of Tangshan Transportation Group Co. Ltd Suining Central Hospital Haikou Municipal Hospital Suining Hospital of Traditional Chinese Medicine Huabei Oil Field General Hospital Group Sun Yat-Sen University Cancer Center Huainan Eastern Hospital The 452nd PLA Hospital Huanggang Center Hospital The Daqing Oil Field General Hospital Group

In this region Miscellaneous Neurological ✪ Pancreatic cancer ◆ Kidney cancer Asia* ✖ Soft tissue cancer ■ Essential tremor ✪ Prostate cancer ◆ Prostate cancer ✖ Soft tissue tumors, benign ■ Parkinson’s disease ✪ Endocrine Disorders Soft tissue cancer Women’s Health ▲ Thyroid nodules Musculoskeletal Oncological Pain ✿ Breast cancer ● ✪ ▼ ✿ Gastrointestinal Bone metastases Bone metastases Osteoid osteoma Breast fibroadenoma ● Osteoid osteoma ✪ ✿ ✤ Liver cancer Breast cancer Urological Uterine adenomyosis ✪ Kidney cancer ✿ ✤ Pancreatic cancer ◆ Benign prostatic hyperplasia Uterine fibroids ✪ Liver cancer

Commercial treatment sites provide treatment with a focused ultrasound system for a regulatory approved indication. *Indications not being researched in a region have been removed from the key.

50 Focused Ultrasound Foundation | State of the Field 2017 COMMERCIAL TREATMENT

Commercial Treatment Sites by Region

The First Affiliated Hospital of Chongqing Medical University Henan Linying County Hospital of Traditional The First Affliated Hospital of Wannan Medical College Chinese Medicine The First People’s Hospital of Shijiazhuang Hezhe No. 2 People’s Hospital The Fourth People’s Hospital of Shenzhen Jiangsu Guanyun County People’s Hospital The Second Affiliated Hospital Of Hebei Medical University Jiaxing Maternal and Child Health Hospital The Second Artillery General Hospital of Chinese PLA Jilin Ganan County People's Hospital The Sixth People’s Hospital of Neijiang Jinan Maternal and Child Health Hospital The Tenth People’s Hospital of Shanghai Jinzhou Central Hospital The Third Xiangya Hospital of Central South University Kaifeng Tongxu County People’s Hospital West China Hospital, Sichuan University Lu’an Civily Hospital Xiaoshan Birth Control Station No. 2 People’s Hospital of Guangzhou Xijing Hospital of The Fourth Military Medical University Peking University People's Hospital Yanbian Tianquan Hospital Qinghai Red Cross Hospital Yongchuan Maternal and Child Health Hospital Qingyuan Maternal and Child Health Hospital Zibo Municipal Maternal & Children Health Hospital Quanzhou Macare Hospital Qujing Qilin District People’s Hospital ✿ ✿ Commerial treatment centers Renji Hospital for two indications Ruzhou People’s Hospital Shanghai Shuguang Hospital Baicheng Central Hospital Shanxi Zhouzhi County People's Hospital Chongqing Jiangbei Hospital of Traditional Southern Medical University Chinese Medicine Tai'an Maternal and Child Health Hospital Chongqing Kai County Maternal and Child Health Hospital Taizhou Huangyan District Hospital of Traditional Chongqing Tongliang County People’s Hospital Chinese Medicine Dongguan Taiping People's Hospital The Second Affiliated Hospital of Zhejiang University First Affiliated Hospital of Jinan University Weihai Central Hospital First Affiliated Hospital of Nanchang University Wuhan Puren Hospital First Affiliated Hospital of Nanjing Medical University Xi’an Chang’an Hospital First People’s Hospital of Guiyang Xinjiang Korla Hospital Foshan Chancheng District Central Hospital Yichang No. 1 People's Hospital Fuzhou Maternal and Child Health Hospital Yiyang Medical College Affiliated Hospital Guangdong Maternal and Child Health Hospital Zhangqiu Maternal and Child Health Hospital Guangdong Provicial Hospital of Traditional Zhejiang Quhan Hospital Chinese Medicine Zhengzhou Hospital of Traditional Chinese Medicine Guizhou Province Hospital of Traditional Chinese Medicine Zhongshan Guangji Hospital

Commercial treatment sites provide treatment with a focused ultrasound system for a regulatory approved indication. *Indications not being researched in a region have been removed from the key.

Focused Ultrasound Foundation | State of the Field 2017 51 COMMERCIAL TREATMENT

Commercial Treatment Sites by Region

Commerial treatment centers Japan for other indications ✤ ✪ ✖✪✖ Affiliated Hospital of Yokohama University ✿ First Affiliated Hospital of Medical ●▼◆ ✪ ✿ College of Xi’an Jiaotong University ✪ ✿ ✤ ✪ ✖✪✖ First Affiliated Hospital of Zunyi ◆ Aino Hospital ●▼◆ ✪ ✿ Medical College ✿ Aizu Chuo Hospital ✪✿ ✿ ✿✪✿ Breastopia Namba Hospital ◆✪ Foshan Hospital ✤ ✪ ✖✪✖ Clinical E.T. ✿ Huaibei Peach Hospital ●▼◆ ✪ ✿ ✿ Nanjing Medical University ✪ ✿ ✿ Peking Union Medical Center ◆ ◆✪ Fuji Kosei Hospital ▲✤ ✪ ●▼ Queen Mary Hospital of the University ✿ Fukuoka Tokushukai Medical Center ◆ ✪✿✪✿ of Hong Kong ◆ Harasanshin Hospital ✿ ◆ Hasegama Hospital ✿ Shanghai Sixth People's Hospital ◆ Hirakata Civic Hospital ✿ Wenzhou Medical University ◆ Hiroshima Kosei Hospital ■ Hokuto Hospital ◆ India Iseikai Hospital ✿ Itabashi Chuo Medical Center, Tokyo ✿ Bharat Scans ◆ Iwaki Urological Hospital ✿ Concept Medicare Pvt Ltd. ✤ ✪ ✖✪✖ Japan Affiliated Hospital of ◆✪✿ Jaslok Hospital and Research Centre ●▼◆ ✪ ✿ Chiba University ◆✪ Muljibhai Patel Urological Hospital ✪ ✿ ◆✪ Rajiv Gandhi Cancer Research Hospital ◆ Kashiwa Forest Clinic ✿ SRL Diagnostics - Jankharia Imaging ✤ ✪✤ ✪ ✖ Kobe Saisei Mirai Clinic ✿ Sunrise Hospital ✪ ✖ ●✪◆ ✿ ✪ ◆✪✪✿ Women’s Center India ✿ Iran ●▼ Kochi University Hospital ◆ ◆✪ Pirooz One Day Surgery Clinic ◆ Kotobukimachi Urology ◆ Maruyama Hospital ◆ Oita Urology Hospital ◆ Okayama Central Hospital

Commercial treatment sites provide treatment with a focused ultrasound system for a regulatory approved indication. *Indications not being researched in a region have been removed from the key.

52 Focused Ultrasound Foundation | State of the Field 2017 COMMERCIAL TREATMENT

Commercial Treatment Sites by Region

■ Osaka University Lebanon ◆ Saka Urological Hospital ◆✪ Bellevue Medical Center ✿ Sapporo Toho hospital Malaysia ◆ Senen Hospital ✿ Hospital Universiti of Sains Malaysia ✿ Shinsuma General Hospital ■ Shin Yurigaoka General Hospital Myanmar ◆ Takanobashi Central Hospital ◆✪ Yangon Specialty Hospital ◆ Takayama Hospital ◆ Takeuchi Hospital Qatar ✿ ◆ THS Sidra Medical and Research Center ◆✪ Tokai University Republic of Korea ■ Tokyo Women’s Medical Hospital ✿ CHA Bundang Medical Center ◆ Tomari Urology ✿ Chaum Hospital ◆ Yahata General Hospital ✿ Dongtan Jeil Women's Hospital ◆ Yakuin Urology Hospital ▲◆ ◆✪✿ Echo Healthcare ✿ Yamanashi University Medical Hospital ✿ ✿ Gangnam St. Peter’s Hospital ◆ Yamato Hospital ✿ Heryoojae Women’s Hospital ✿ Kazakhstan Hwamyeong Ilsin Christian Hospital ✿ ✿ ✤ ✪ ●▼ ✖ National Medical Research Center Hyosung Daegu Hospital ✪ ✖ ◆ ✪ ✿ ✿ I Jeil OBGY Clinic ✪ ✿ ✤ ✪ ●▼ ✖ Incheon Christian Hospital ✪ ✖ ◆ ✪ ✿ Kingdom of Saudi Arabia ✪ ✿ ✤ ✪ ●▼ ✖ King Fahad Medical City ✤ ✪ ●▼ ✖ Incheon St. Mary’s Hospital of the ✪ ✖ ◆ ✪ ✿ ✪ ✖ ◆ ✪ ✿ Catholic University ✪ ✿ ✪ ✿ ✤ ✪ ●▼ ✖ King Khalid University Hospital ✿ ✿ Jamsil Joeun Woman’s Hospital ✪ ✖ ◆ ✪ ✿ ✿ ✪ ✿ Kohwoon Women’s Hospital ✿ ✿ Kwons Women Clinic ✿ Medisum OBGY Clinic ✿ MINT Intervention Hospital

Commercial treatment sites provide treatment with a focused ultrasound system for a regulatory approved indication. *Indications not being researched in a region have been removed from the key.

Focused Ultrasound Foundation | State of the Field 2017 53 COMMERCIAL TREATMENT

Commercial Treatment Sites by Region

✿ Mizmoa Women’s Clinic Thailand ◆✪ Samsung Medical Center ✤ ✪ ◆ ◆✪ Chularat 9 Airport Hospital ✿ ✿ ✿ Uijeongbu St. Peter’s Hospital ◆✪ ✿ Yonsei University Health System Samitivej Sukhumvit Hospital ■ YUMC Severance Hospital United Arab Emirates Singapore ◆✪ Al Zahra Hospital ✿ KK Women and Children’s Hospital Uzbekistan Taiwan ◆ ◆✪ Samarkand Urology Center ●✪✿ Cardinal Tien Hospital Vietnam ◆✪ Chang Gung Memorial Hospital (Chiayi) ✿ Bao Son Hospital ◆✪ Chang Gung Memorial Hospital ✿ Phuc An Khang Hospital (Kaohsiung) ◆✪ Chang Gung Memorial Hospital (Linkou) ◆✪ Chang Gung Memorial Hospital (Taipei) ◆✪ Changhua Christian Hospital ◆✪ China Medical University Beigang Hospital ◆✪ China Medical University Hospital ▲ ✿ Dermacare ◆✪ E-Da Hospital ◆✪ Kaoshiung Veterans General Hospital ◆✪ Mackay Memorial Hospital ◆✪ National Defense Medical Center ◆✪ New Taipei City Hospital Banciao Branch ◆✪ New Taipei City Hospital Sanchong Branch ◆✪ Show Chwan Memorial Hospital ◆✪ Taichung Veterans General Hospital ●✪ Taipei Medical University Hospital

Commercial treatment sites provide treatment with a focused ultrasound system for a regulatory approved indication. *Indications not being researched in a region have been removed from the key.

54 Focused Ultrasound Foundation | State of the Field 2017 COMMERCIAL TREATMENT

Commercial Treatment Sites by Region

Australia ✿ Future Medical Imaging Group ✿ The Royal Women’s Hospital 2 Melbourne Oceania

Egypt ▲ ✿ EgyHiFu ◆✪ Teachers Hospital - Cairo

3 Morocco Africa ◆✪ Hopital Militaire Med V.

In these regions Endocrine Disorders Urological Oceania* ▲ Thyroid nodules ◆ Prostate cancer Africa* Oncological Women’s Health ✪ Prostate cancer ✿ Breast fibroadenoma ✿ Uterine fibroids

Commercial treatment sites provide treatment with a focused ultrasound system for a regulatory approved indication. *Indications not being researched in a region have been removed from the key.

Focused Ultrasound Foundation | State of the Field 2017 55 COMMERCIAL TREATMENT

Cost of Focused Ultrasound Compared to Standard of Care*

Back pain & neck pain | 82 million patients Depression | 15,000,000 patients Physical therapy $50–400 per session Medication $360–2,000 per year Surgery $24,000–100,000 Electroconvulsive therapy $25,000 Transcutaneous electrical nerve stimulation $10–300 Psychotherapy $3,000–13,000 per year Steroid injections $2,000 Vagus nerve stimulation $5,000–30,000 Medication $2,000 per year Transcranial magnetic stimulation (TMS) $15,000 Focused Ultrasound n/a Focused Ultrasound n/a

Bone metastases | 280,000 patients Essential tremor | 10,000,000 patients Surgery n/a Physical therapy $50–400 per session Radiation therapy $8,000 Medication $300 per year Chemotherapy $24,000–100,000 Deep brain stimulation $30,000–50,000 Radiotherapy $15,000 Stereotactic radiosurgery$40,000 Medication (pain & steroid) $12,000 per year Focused Ultrasound $22,000–46,000 Focused Ultrasound $4,000–20,000 Glaucoma | 3,000,000 patients Breast cancer | 2,800,000 patients Medication per year $35–4,000 per year Mastectomy $15,000–50,000 Surgery $1,000 Radiation $20,000 Focused Ultrasound $1,000 Lumpectomy $7,000–20,000 Chemotherapy $30,000 Kidney cancer | 500,000 patients Focused Ultrasound n/a Surgery $15,000–500,000 Radiofrequency ablation $3,000–5000 Breast fibroadenoma | 24,000,000 patients Cryoablation n/a Surgery $15,000–50,000 Arterial embolization $800–27,000 Frequent U/S monitoring $20,000 Focused Ultrasound n/a Cryoablation $7,000–20,000 Focused Ultrasound n/a

Patient numbers reflect the prevalence of each indication in the U.S. n/a = information currently unavailable

*Standard treatment costs are averages based on US pricing and meant to be used as a reference tool only. Costs for the same health care service can vary a great deal by geographic location and health care provider. 56 Focused Ultrasound Foundation | State of the Field 2017 COMMERCIAL TREATMENT

Cost of Focused Ultrasound Compared to Standard of Care*

Liver cancer | 67,000 patients Parkinson’s disease | 1,000,000 patients Surgery $23,000–100,000 Medication $2,500 per year Chemotherapy $30,000 Deep brain stimulation $35,000–100,000 Thermal ablation n/a Focused Ultrasound $22,000 Chemo embolization $800–27,000 Radiation $25,000 Prostate cancer | 138,000 patients Immunotherapy n/a Surgery $12,000 Cryosurgery n/a Radiation (office or HOPD) $38,000 Focused Ultrasound n/a Chemotherapy $7,000 – 30,000 Cryotherapy $12,000 Neuropathic pain | 20,000,000 patients Focused Ultrasound $25,000 Medication $150–60,000 per year Soft tisssue cancer | 600,000 patients Electrical stimulation $24,000 Surgery $9,000–13,000 Physical therapy $50–400 per session Radiation $25,000 Psychotherapy $150–200 per session Chemotherapy $2,000 Focused Ultrasound n/a Focused Ultrasound $20,000

Obsessive-compulsive disorder | 3,300,000 patients Thyroid nodules | 15,000,000 patients Medication $150–60,000 per year Medication $1,000 per year Cognitive behavior therapy $3,000–13,000 per year Surgery $15,000 Psychotherapy $150–200 per session Radioactive iodine $4,000 Focused Ultrasound n/a Focused Ultrasound $3,000

Osteoid osteoma | 80,000 patients Uterine adenomyosis | 15 million patients Medication $150–24,000 per year Medication $200–6,000 per year Curettage $3,000 Uterine artery embolization $21,000 Radiofrequency ablation $7,000 Endometrial ablation $3,000–6,000 Focused Ultrasound $20,000 Focused Ultrasound $4,000–9,000

Pancreatic cancer | 50,000 patients Uterine fibroid | 13,600,000 patients Surgery $40,000–85,000 Hysterectomy $17,000 Radiation $25,000 Myomectomy $19,000 Chemotherapy $24,000–54,000 Uterine artery embolization $21,000 Focused Ultrasound n/a Endometrial ablation $13,000 Focused Ultrasound $4,000–14,000

*Standard treatment costs are averages based on US pricing and meant to be used as a reference tool only. Costs for the same health care service can vary a great deal by geographic location and health care provider. Focused Ultrasound Foundation | State of the Field 2017 57 FOCUSED ULTRASOUND FOUNDATION

Cumulative Focused Ultrasound Foundation Activities

FOSTER CREATE KNOWLEDGE COLLABORATION INCREASE AWARENESS OVERCOME BARRIERS 206 5 578 3 patients symposia media placements reimbursement workshops treated in 29 clinical trials 53 112 18 external meetings events working groups 21 $6.8M workshops AGGREGATE & SHARE CULTIVATE THE spent on KNOWLEDGE NEXT GENERATION completed projects 15 communities 28,600 98 $33.2M 3 newsletter subscribers interns secured in international databases follow-on funding 387,000 14 to engage stakeholders website visits in 2016 fellows and build communities

Foundation newsletter distribution Foundation continues to be considered a leader in the field and website traffic at an all-time high by fostering collaboration among researchers, manufacturers, doctors, and patient organizations. In 2016, for the first The Focused Ultrasound Foundation has seen a steady time the Symposium offered a live-streaming option for the increase in our newsletter distribution (page 59, top left) and plenary sessions. Over 400 people from across the world website visits (page 59, top right) since its founding in 2006. registered to watch the Symposium online. At the beginning of 2016, the Foundation released a short book by board member John Grisham called The Tumor. Cumulative funding increases impact This publication has been distributed to over 800,000 people of donations fivefold in just over one year. It has created an explosion of awareness Since its establishment in 2006, the Focused Ultrasound as seen in the 2016 numbers for website visits and newsletter Foundation has become the largest nongovernmental distribution, which have both more than doubled from the source of funding for focused ultrasound research (page 59, previous year (page 59, top). bottom right). The Foundation has awarded 6.8 million dollars to date in completed research projects which have Addition of virtual attendance platform resulted in 33.2 million dollars in follow-on funding, more than doubles symposium attendance a 5:1 ratio for investment. The numbers of Focused Ultrasound Foundation Symposium attendees and presentations at our biennial meeting (page 59, bottom left) have steadily increased over the years and the

58 Focused Ultrasound Foundation | State of the Field 2017 FOCUSED ULTRASOUND FOUNDATION

Focused Ultrasound Foundation Focused Ultrasound Foundation Newsletter Distribution Website Visits Per year Per year

30,000 400,000

24,000 320,000

18,000 240,000

12,000 160,000

6,000 80,000

0 2013 2014 2015 2016* 0 2013 2014 2015 2016 *Includes subscribers to our stay-in-touch list.

Focused Ultrasound Foundation Focused Ultrasound Foundation Symposium Attendance and Presentations Cumulative Funding ■ Attendance ■ Presentations ■ Virtual attendance ■ Foundation funding ■ Follow-on funding

500 $40M

400 32

300 24

200 16

100 8

0 2010 2012 2014 2016* 0 2013 2014 2015 2016

Focused Ultrasound Foundation | State of the Field 2017 59 BIOEFFECTS RESEARCH

All Bioeffects Research Sites by Region

152 Worldwide Total 68 39 44 North America Europe Asia 1 Oceania

Bioeffects research sites are any site investigating how focused ultrasound interacts with the body.

60 Focused Ultrasound Foundation | State of the Field 2017 BIOEFFECTS RESEARCH

Bioeffects Research Sites in North America 63 US States + Puerto Rico

Massachusetts 1 4 4 2 1 4 1 2 11 1 12 1 2 Washington, DC 1 1 1 4 1 1 1 Maryland 1 1 4 1 51 Puerto Rico 1

5 68 Canada North America 63 United States

Focused Ultrasound Foundation | State of the Field 2017 61 BIOEFFECTS RESEARCH

Bioeffects Research Sites By Region

Canada ● ● ● ● ● Columbia University ● ● ● ● ● ● Ryerson University ● ● ● ● Drexel University ● ● ● ● ● Sunnybrook Health Sciences Centre ● ● Duke University 68 ● ● ● ● ● North America ● ● ● ● Food and Drug Administration ● ● ● ● ● The Hospital for Sick Children (SickKids) ● ● ● Fox Chase Cancer Center ● ● ● ● ● Georgia Institute of Technology ● ● ● ● ● Thunder Bay Regional Research Institute ● ● ● ● ● ● Indiana University School of Medicine ● ● University of Alberta Iowa State University ● ● ● ● ● Johns Hopkins University School of Puerto Rico Medicine ● University of Puerto Rico ● ● Medical University of South Carolina ● Michigan State University United States ● Montefiore Medical Center ● Arizona State University ● ● ● National Institutes of Health ● Arkansas Heart Hospital ● ● North Carolina State University ● ● ● ● ● Boston University ● ● Northeastern University ● ● ● ● ● Brigham and Women’s Hospital ● ● ● ● ● Oklahoma State University ● ● ● ● ● ● ● ●

● ● ● BURL Concepts Inc. ● ProMedica Toledo Hospital ● ● California Institute of Technology ● ● Purdue University - West Lafayette ● ● ● ● ● Children’s National Health System ● Roswell Park Cancer Institute ● ● ● ● ● ● San Diego State University ● CHI St. Luke’s Health ● ● ● ● ● Stanford University School of Medicine ● City College of New York ● ● ● ● ● ● City of Hope ● Swedish Neurosciences Institute ● ● ● ● ● ● The Methodist Hospital

Bioeffects ● Amplification of cancer ● Cavitation ● Hyperthermia ● Renal denervation North America biomarkers ● Clot lysis ● Immunomodulation ● Sonodynamic therapy ● Angiogenesis ● Drug activity enhancement ● Increased vascular ● Stem cell delivery ● Blood-brain barrier opening ● Drug delivery permeability ● Thermal ablation ● Blood vessel occlusion ● Hemostasis ● Neuromodulation ● Vasodilation ● Cardiac pacing* ● Histotripsy ● Radiation sensitization *Not in this area

Bioeffects research sites are any site investigating how focused ultrasound interacts with the body.

62 Focused Ultrasound Foundation | State of the Field 2017 BIOEFFECTS RESEARCH

Bioeffects Research Sites By Region

● ● ● ● ● Tulane University ● ● ● ● ● University of Texas Southwestern ● Medical Center ● ● ● ● ● University of California Davis ● ● ● ● ● University of Utah ● ● ● ● ●

● ● University of California Irvine ● ● ● ● ● University of Virginia Health System ● ● ● ● ● ● ● University of California Los Angeles ● ● ● ● ● University of Washington ● ● University of California San Diego ● ● ● ● ● Thornton Hospital ● ● ● ● ● ● ● ● University of California San Francisco ● ● ● ● ● ● ● ● ● ● University of Chicago Vanderbilt University ● ●● ● ● ● ● ● ● ● ● ● ● ● ● University of Cincinnati Virginia Tech Carilion Reseach Institute ● ● ● ● ● ● ● ● Wake Forest University Baptist Medical ● ● ● University of Colorado Boulder Center ● ● ● ● ● ● University of Kansas Washington University in St. Louis ● ● ● ● ● ● University of Maryland School of Worcester Polytechnic Institute ● ● ● ● ● Medicine ● ● ● ● ●

● ● ● ● ● University of Michigan ● ● ● ● ● University of Minnesota ● ●

● University of Nebraska Medical Center ● University of North Carolina ● University of Pennsylvania ● ● ● ● University of Pittsburgh Medical Center ● ● ● ● ● University of Southern California ● Keck Hospital ● University of Texas at Austin ● ● ● ● ● University of Texas MD Anderson ● ● Cancer Center

Bioeffects research sites are any site investigating how focused ultrasound interacts with the body.

Focused Ultrasound Foundation | State of the Field 2017 63 BIOEFFECTS RESEARCH

Bioeffects Research Sites in Europe 39 Sites

1 Denmark 3 Norway 2 Russia

9 UK 5 2 Germany The Netherlands 4 France 5 Italy 3 1 1 Bulgaria Switzerland Spain

1 Cyprus

2 Israel

64 Focused Ultrasound Foundation | State of the Field 2017 BIOEFFECTS RESEARCH

Bioeffects Research Sites by Region

Bulgaria Italy ● University Hospital of Endocrinology ● ● ● ● European Institute of Oncology ● ● ● ● ● Istituto Ortopedico Rizzoli Cyprus ● ● ● ●● 39 ● ● ● ● ● Cyprus University of Technology ● ● ● Europe ● ● ● ● ● Scuola Superiore Sant’Anna Denmark ● ●● ● Aarhus University Hospital ● ● University of Milano-Bicoca ● France University of Turin ● ● ● CHU de Tours - Hôpital Bretonneau Netherlands ● ● ● ● ● Inserm Lyon ● ● Radboud University Nijmegen Medical ● ●● ● ● Centre ● ● ● ● ● ● ● ● University Medical Center Utrecht ● ● ● ● ● Institut Langevin - ESPCI ● Norway ● University of Franche-Comté ● Haukeland University Hospital Germany ● ● Norwegian University of Science and Technology ● ● ● ● ● German Cancer Research Center ● ● Heidelberg ● The Intervention Centre, Oslo University Hospital Rikshopitalet ● ●● ● ● University Hospital of Cologne ● Russia ● University Hospital Schleswig-Holstein ● N. N. Petrov Research Institute of Oncology ● ● ● ● ● University of Heidelberg ● ● ● Rostov Scientific Research Institute of Oncology ● ● University of Munich Spain Israel ● ● ● La Paz University Hospital ● ● Chaim Sheba Medical Center ● ● Technion - Israel Institute of Technology

Bioeffects ● Amplification of cancer ● Cavitation ● Hyperthermia ● Renal denervation* Europe biomarkers ● Clot lysis ● Immunomodulation ● Sonodynamic therapy ● Angiogenesis ● Drug activity enhancement ● Increased vascular ● Stem cell delivery* ● Blood-brain barrier opening ● Drug delivery permeability ● Thermal ablation ● Blood vessel occlusion ● Hemostasis ● Neuromodulation ● Vasodilation* ● Cardiac pacing ● Histotripsy ● Radiation sensitization *Not in this area

Bioeffects research sites are any site investigating how focused ultrasound interacts with the body.

Focused Ultrasound Foundation | State of the Field 2017 65 BIOEFFECTS RESEARCH

Bioeffects Research Sites by Region

Switzerland ● ● ● ● ● FUS-Center, University of Zurich, ● ● ● Children's Hospital ● ● University of Geneva ● University of Zurich

United Kingdom ● ● ● Churchill Hospital ● Imperial College London ● ● Institute for Medical Science and Technology ● ● ● King’s College Hospital ● ● ● St. Mary’s Hospital ● ● ● ● ● The Institute of Cancer Research ● ●●

● University College London ● University of Hull ● University of Oxford

Bioeffects research sites are any site investigating how focused ultrasound interacts with the body.

66 Focused Ultrasound Foundation | State of the Field 2017 BIOEFFECTS RESEARCH

Bioeffects Research Sites in Asia and Oceania 44 1 Sites in Asia Site in Oceania

9 Japan 9 2 15 Korea Iran China 7 Taiwan

1 Singapore 1 Malaysia

1 Australia

Focused Ultrasound Foundation | State of the Field 2017 67 BIOEFFECTS RESEARCH

Bioeffects Research Sites by Region

China Japan ● Beijing Normal University ● Fukuoka University School of Medicine ● ● ● ● Chongqing Medical University ● Hokuto Hospital 44 ● First Affiliated Hospital of Nanjing ● Kobe Saisei Mirai Clini Medical University Asia ● ● Kochi University Hospital ● First Affiliated Hospital of Shihezi ● University National Center of Neurology and Psychiatry ● Nanjing Medical University ● ● Teikyo University ● ● Peking Union Hospital, Chinese ● ● Academy of Medical Sciences Tohoku University ● ● ● ● ● Shenzhen Institutes of Advanced Tokyo University of Pharmacy and Technology - Chinese Academy Life Sciences of Science ● ● Washokai Sadamoto Hospital ● ● Shenzhen University Malaysia ● ● Southern Medical University ● ● University of Malaya ● ● Sun Yat-Sen University ● ● The Third Xiangya Hospital of Central Republic of Korea South University ● Asan Medical Center ● ● The University of Hong Kong ● Chonnam National University ● ● Third Military Medical University ● Daegu-Gyeongbuk Medical Innovation ● ● Wenzhou Medical University Foundation (DGMIF) ● ● ● ● Xi’an Jiaotong University Ewha Womans University Medical Center ● Korea Institute of Science and Technology Iran ● Samsung Advanced Institute of Technology ● ● Iran University of Medical Sciences ● Sogang University ● Islamic Azad University ● The Catholic University of Korea

● ● ● ● YUMC Severance Hospital

Bioeffects ● Amplification of cancer ● Cavitation ● Hyperthermia ● Renal denervation Asia biomarkers ● Clot lysis ● Immunomodulation ● Sonodynamic therapy ● Angiogenesis ● Drug activity enhancement ● Increased vascular ● Stem cell delivery ● Blood-brain barrier opening ● Drug delivery permeability ● Thermal ablation ● Blood vessel occlusion ● Hemostasis ● Neuromodulation ● Vasodilation ● Cardiac pacing* ● Histotripsy ● Radiation sensitization *Not in this area

Bioleffects research sites are any site investigating how focused ultrasound interacts with the body.

68 Focused Ultrasound Foundation | State of the Field 2017 BIOEFFECTS RESEARCH

Bioeffects Research Sites by Region

Singapore ● ● ● ● ● Nanyang Technological University ● ● ● ● ● ● ● ●

Taiwan ● Academia Sinica ● ● ● ● ● Chang Gung University ● ●

● National Chiao Tung University ● National Health Research Institutes ● ● ● ● National Taiwan University ● ● ● ● ● National Tsing Hua University ● ● ● ●

● National Yang-Ming University

Australia 1 ● ● University of Queensland Oceania

Bioeffects ● Amplification of cancer ● Cavitation* ● Hyperthermia* ● Renal denervation* Oceania biomarkers* ● Clot lysis* ● Immunomodulation* ● Sonodynamic therapy* ● Angiogenesis* ● Drug activity enhancement* ● Increased vascular ● Stem cell delivery* ● Blood-brain barrier opening ● Drug delivery permeability* ● Thermal ablation* ● Blood vessel occlusion* ● Hemostasis* ● Neuromodulation* ● Vasodilation* ● Cardiac pacing* ● Histotripsy* ● Radiation sensitization* *Not in this area

Bioeffects research sites are any site investigating how focused ultrasound interacts with the body.

Focused Ultrasound Foundation | State of the Field 2017 69 TECHNICAL RESEARCH

All Technical Research Sites by Region

122 Technical research sites worldwide 47 45 30 North America Europe Asia

Technical research sites are any site investigating hardware or software solutions related to focused ultrasound.

70 Focused Ultrasound Foundation | State of the Field 2017 TECHNICAL RESEARCH

All Technical Research Sites by Region

Technical research sites are any site investigating hardware or software solutions related to focused ultrasound.

■ North America ■ Europe ■ Asia 4 Canada 1 Bulgaria 10 China 43 United States 1 Cyprus 1 India 1 Denmark 1 Iran 1 Finland 8 Japan 5 France 5 Republic of Korea 9 Germany 1 Singapore 2 Israel 4Taiwan 7 Italy 2 The Netherlands 2 Norway 2 Poland 1 Russia 3 Switzerland 8 United Kingdom

Focused Ultrasound Foundation | State of the Field 2017 71 TECHNICAL RESEARCH

Technical Research Sites by Region

Canada ■ ■ University of Illinois at Urbana- ■ ■ ■ ■ Ryerson University Champaign ■ ■ ■ ■ ■ ■ ■ ■ ■ Sunnybrook Health Sciences Centre University of Maryland School of Medicine ■ ■ ■ The Hospital for Sick Children (SickKids) ■ ■ ■ ■ ■ University of Michigan 47 ■ ■ ■ Thunder Bay Regional Research Institute ■ ■ ■ ■ North America University of Minnesota United States ■ University of Nebraska Medical Center ■ Artann Laboratories ■ ■ ■ University of Southern California ■ Keck Hospital FUS monitoring ■ ■ ■ ■ Boston University ■ FUS physics ■ ■ University of Texas MD Anderson ■ ■ ■ Brigham and Women’s Hospital ■ FUS transducer technology Cancer Center ■ BURL Concepts Inc. ■ ■ ■ ■ ■ University of Texas Southwestern MR imaging for ■ FUS guidance Children’s National Health System Medical Center ■ Ultrasound imaging for ■ CHI St. Luke’s Health ■ ■ ■ ■ ■ University of Utah FUS guidance ■ ■ Cincinnati Children’s Hospital ■ University of Virginia Health System Medical Center ■ ■ ■ ■ ■ University of Washington ■ City of Hope ■ ■ ■ ■ ■ Vanderbilt University ■ ■ ■ Columbia University ■ Virginia Tech Carilion Reseach Institute ■ ■ ■ Drexel University ■ Wake Forest University Baptist ■ Duke University Medical Center ■ Food and Drug Administration ■ ■ ■ Worcester Polytechnic Institute ■ ■ ■ Johns Hopkins University School of Medicine ■ ■ ■ Mayo Clinic - Minnesota ■ ■ North Carolina State University ■ ■ Ohio State University ■ ■ Oklahoma State University ■ ProMedica Toledo Hospital ■ ■ ■ ■ Stanford University School of Medicine ■ Swedish Neurosciences Institute ■ ■ ■ The Methodist Hospital ■ ■ Tulane University ■ ■ ■ ■ ■ University of California Davis ■ University of California Irvine ■ ■ University of California Los Angeles ■ ■ ■ ■ University of California San Francisco ■ ■ ■ ■ University of Chicago ■ ■ ■ University of Cincinnati

Technical research sites are any site investigating hardware or software solutions related to focused ultrasound.

72 Focused Ultrasound Foundation | State of the Field 2017 TECHNICAL RESEARCH

Technical Research Sites by Region

Bulgaria ■ ■ Niguarda Hospital ■ University Hospital of Endocrinology ■ ■ ■ Scuola Superiore Sant’ Anna ■ ■ University of Milano-Bicoca Cyprus ■ University of Rome - La Sapienza 45 ■ ■ ■ Cyprus University of Technology Netherlands Europe Denmark ■ Radboud University Nijmegen ■ Aarhus University Hospital Medical Centre ■ FUS monitoring ■ ■ ■ ■ ■ University Medical Center Utrecht Finland ■ FUS physics ■ VTT Technical Research Centre of Finland ■ FUS transducer technology Norway ■ ■ Norwegian University of Science and MR imaging for France FUS guidance Technology ■ ■ CHU de Bordeaux - Hôpital Saint-André ■ Ultrasound imaging for ■ The Intervention Centre, Oslo University FUS guidance ■ ■ CHU de Tours - Hôpital Bretonneau Hospital Rikshopitalet ■ ■ ■ ■ ■ Inserm Lyon Poland ■ ■ ■ ■ ■ Institut Langevin - ESPCI ■ ■ ■ Institute of Fundamental Technological ■ ■ University of Strasbourg Research - Polish Academy of Sciences ■ ■ Germany Szpital Pro-Familia ■ ■ Charite Universitaetsmedizin Berlin Russia ■ ■ ■ Fraunhofer Institut IBMT ■ N. N. Petrov Research Institute ■ ■ Fraunhofer MEVIS of Oncology ■ ■ ■ German Cancer Research Center Heidelberg ■ ■ Physikalisch-Technische Bundesanstalt Switzerland ■ ■ ■ ■ University Hospital of Cologne FUS-Center, University of Zurich, Children’s Hospital ■ University Hospital Schleswig-Holstein ■ ■ University of Basel ■ University of Heidelberg ■ ■ University of Geneva ■ University of Munich United Kingdom Israel ■ Basingstoke and North Hampshire ■ Action Physics Hospital ■ Technion - Israel Institute of Technology ■ Imperial College London ■ St. Mary’s Hospital Italy ■ ■ ■ ■ ■ The Institute of Cancer Research ■ ■ ■ European Institute of Oncology ■ University College London ■ ■ Istituto Superiore di Sanita ■ ■ ■ University of Dundee ■ Laboratorio di Tecnologie Oncologiche ■ (LATO) HSR Giglio, Fondazione Istituto University of Hull San Raffaele G. Giglio di Cefalu ■ ■ ■ ■ University of Oxford

Technical research sites are any site investigating hardware or software solutions related to focused ultrasound.

Focused Ultrasound Foundation | State of the Field 2017 73 TECHNICAL RESEARCH

Technical Research Sites by Region

China Singapore ■ ■ Chongqing Medical University ■ ■ ■ ■ Nanyang Technological University ■ ■ Peking Union Hospital, Chinese Academy of Medical Sciences Taiwan 30 ■ ■ Shanghai Jiaotong University ■ ■ ■ Chang Gung University Asia ■ ■ Shenzhen Institutes of Advanced ■ I-Shou University Technology - Chinese Academy ■ National Taiwan University of Science ■ ■ ■ ■ National Tsing Hua University ■ FUS monitoring ■ Southern Medical University ■ FUS physics ■ The University of Hong Kong ■ FUS transducer technology ■ Third Military Medical University ■ MR imaging for ■ Tianjin Medical University FUS guidance ■ Wuhan University ■ Ultrasound imaging for ■ FUS guidance Xi’an Jiaotong University India ■ ■ Supercomputer Education and Research Centre

Iran ■ Islamic Azad University

Japan ■ Breastopia Namba Hospital ■ ■ Hokkaido University ■ Hokuto Hospital ■ Kochi University Hospital ■ National Center of Neurology and Psychiatry ■ ■ Tohoku University ■ ■ University of Tokyo ■ Washokai Sadamoto Hospital

Republic of Korea ■ Asan Medical Center ■ ■ Jeju National University ■ ■ ■ ■ Seoul National University Hospital ■ ■ The Catholic University of Korea ■ ■ YUMC Severance Hospital

Technical research sites are any site investigating hardware or software solutions related to focused ultrasound.

74 Focused Ultrasound Foundation | State of the Field 2017 MANUFACTURERS

Manufacturers Contact Information

Acublate FUS Mobile Profound Medical Inc. London, UK Alpharetta, Georgia Toronto, Canada n/a WEBSITE www.fusmobile.com WEBSITE www.profoundmedical.com WEBSITE n/a EMAIL [email protected] EMAIL [email protected] EMAIL Alpinion Medical Systems HistoSonics, Inc. Promedica Bioelectronics Seoul, Korea Ann Arbor, Michigan Rome, Italy www.alpinion.com WEBSITE www.histosonics.com WEBSITE www.promedicasrl.eu/en/sonowell-4.html [email protected] EMAIL [email protected] EMAIL WEBSITE [email protected] EMAIL Beijing Yuande Bio-Medical Image Guided Therapy (IGT) Engineering Pessac, France Shanghai A&S Co., LTD Beijing, China www.imageguidedtherapy.com WEBSITE Shanghai, China www.yuande.com WEBSITE www.imageguidedtherapy.com/Contact-Us/ EMAIL www.aishen.com.cn/english/ WEBSITE [email protected] EMAIL [email protected] EMAIL Imasonic BrainSonix Voray-sur-l’Ognon, France Shenzhen PRO-HIFU Medical Sherman Oaks, California www.imasonic.com WEBSITE Tech. Co., LTD www.brainsonix.com WEBSITE www.imasonic.com/Company/ContactUs.php Shenzhen, China [email protected] EMAIL INSIGHTEC LTD en.pro-hifu.com/index.html WEBSITE [email protected] EMAIL CarThera Tirat Carmel, Israel Paris, France www.insightec.com WEBSITE Shenzhen Wikkon www.carthera.eu WEBSITE www.insightec.com/about-us/contact-us EMAIL Shenzhen, China [email protected] EMAIL International Cardio Corporation, LLC www.eswl.cn/en/ WEBSITE [email protected] EMAIL Changjiangyuan Technology Minnetonka, Minnesota Development Co., LTD www.hifu-rx.com WEBSITE SonaCare Medical, LLC Shenyang, China [email protected] EMAIL Charlotte, North Carolina www.cjykj.com/en/ WEBSITE Kona Medical www.sonacaremedical.com WEBSITE [email protected] EMAIL Bellevue, Washington [email protected] EMAIL Chongqing Haifu Medical www.konamedical.com WEBSITE Sonic Concepts Technology Co., LTD [email protected] EMAIL Bothell, Washington Chongqing, China Medsonic LTD www.sonicconcepts.com WEBSITE www.haifu.com.cn/en_index.asp WEBSITE Limassol, Cyprus [email protected] EMAIL [email protected] EMAIL www.medsonic.com.cy WEBSITE Sumo Corporations EDAP TMS S.A [email protected] EMAIL Kowloon, Hong Kong Vaulx-en-Velin, France Mianyang Sonic (SUONIKE) Electronic www.sumo.com.hk WEBSITE www.edap-tms.com WEBSITE Mianyang, China [email protected] EMAIL www.edap-tms.com/en/contact EMAIL www.ultrasound.cn/en/ WEBSITE Supersonic Imagine EpiSonica [email protected] EMAIL Aix-en-Provence, France Hsichu City, Taiwan Mirabilis Medical www.supersonicimagine.com WEBSITE www.episonica.com WEBSITE Bothell, Washington [email protected] EMAIL [email protected] EMAIL www.mirabilismedical.com WEBSITE Theraclion EyeTechCare [email protected] EMAIL Malakoff, France Rillieux-la-Pape, France NaviFUS www.theraclion.com WEBSITE www.eyetechcare.com/en/ WEBSITE New Taipei City, Taiwan [email protected] EMAIL www.eyetechcare.com/en/footer/contact/ EMAIL n/a WEBSITE Verasonics FUS Instruments Inc. n/a EMAIL Redmond, Washington Toronto, Canada Philips Healthcare www.verasonics.com WEBSITE www.fusinstruments.com WEBSITE Eindhoven, The Netherlands [email protected] EMAIL [email protected] EMAIL www.philips.co.uk/healthcare/product/HC781360 Wuxi Haiying Medical /sonalleve-mrhifu-therapy-platform WEBSITE Wuxi, China [email protected] EMAIL www.haiyingmedical.com.cn WEBSITE [email protected] EMAIL

Focused Ultrasound Foundation | State of the Field 2017 75 FOCUSED ULTRASOUND FOUNDATION

The Focused Ultrasound Foundation wishes to thank its exceptional Board of Directors and Council for their steadfast dedication to helping make focused ultrasound a clinical reality and improve the lives of millions of patients.

Board of Directors Council

Neal F. Kassell, MD Jane P. Batten Chairman, Focused Ultrasound Foundation Charles H. Seilheimer, Jr. Former Co-chair of Neurosurgery, University of Virginia Co-chairs Dorothy N. Batten . . . . . Founder, iThrive Initiative Former Director, Landmark Communications, Inc. John B. Adams, Jr. Lodewijk J.R. de Vink Ellen Block Founding Partner, Blackstone Health Care Partners, LLC Charles F. Bryan, Jr., PhD Former Chairman & CEO, Warner-Lambert T. Michael Cashman Eugene V. Fife Nancy J. & Thomas N. Chewning Founding Principal, Vawter Capital Marguerite & Norwood Davis Former Chairman, Goldman Sachs International Diane Heller John R. Grisham Cecelia S. Howell Author Dean L. Kamen William A. Hawkins, III Ann Kingston Lead Director, Immucor, Inc. Former Chairman & CEO, Medtronic Syaru Shirley Lin, PhD Amanda Megargel Daniel P. Jordan, PhD President Emeritus, Thomas Jefferson Foundation, Inc. Tony & Jonna Mendez Michael Milken Edward J. “Ned” Kelly, III Former Chairman, Institutional Clients Group, Citigroup Pamela Minetti, MBA Paula F. Newcomb Edward D. Miller, MD Former CEO, Johns Hopkins Medicine Wyndham G. Robertson Mary Lou Seilheimer Frederic H. Moll, MD Co-founder, Intuitive Surgical Alice H. Siegel Chairman & CEO, Auris Surgical Robotics, Inc. Kimberly P. Skelly Steve H. Rusckowski Aaron Stern, MD, PhD President & CEO, Quest Diagnostics Inc. Howard & Fredi Stevenson Former CEO, Philips Healthcare Jane M. Tolleson

Charles Steger, PhD Meredith Jung-En Woo, PhD Former President, Virginia Polytechnic Linda K. Zecher Institute and State University (Virginia Tech)

Andrew C. von Eschenbach, MD President, Samaritan Health Initiatives Former Commissioner, Food and Drug Administration Former Director, National Cancer Institute

Carl P. Zeithaml, DBA Dean and F. S. Cornell Professor of Free Enterprise, McIntire School of Commerce, University of Virginia

76 Focused Ultrasound Foundation | State of the Field 2017

1230 Cedars Court, Suite 206 Charlottesville, VA 22903 434.220.4993 MAIN LINE www.fusfoundation.org

Contact Diana Villalobos Director of Global Relations [email protected] EMAIL 434.326.9833 DIRECT LINE

Copyright 2017. All rights reserved. No part of this report may be reproduced in any written, electronic, recording, or photocopy form or stored in a retrieval system without written permission of the Focused Ultrasound Foundation. Inquiries for reproduction can be directed to Diana Villalobos at [email protected] The Focused Ultrasound Foundation strives to provide the most accurate information possible and, therefore works proactively with the manufactures and research sites to collect the most current data available in advance of the release of this publication. The Focused Ultrasound Foundation assumes no responsibility for any errors or omissions as every precaution has been taken to verify the accuracy of the information contained herein. No liability is assumed for damages that may result from the use of information contained within. If you note something out of date or inaccurate, please submit the new information/ updates to: [email protected]