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Subsidised InhalersSubsidised for or COPD for New Asthma Zealand or COPD March New 2016 Zealand March 2016 Subsidised Inhalers for Asthma or COPD New ZealandMarch 2016 ICS – Inhaled CorticosteroidsICS – Inhaled BECLOMETHASONE ICS – Inhaled Corticosteroids propionate BECLOMETHASONE BECLOMETHASONE BECLOMETHASONE BUDESONIDE FLUTICASONE propionateFLUTICASONE propionate dipropionate Aerosol inhalerdipropionate BECLOMETHASONEdipropionate Aerosol Ultrafine dipropionateBECLOMETHASONEpowder Ultrafine for Subsidisedinhalation powder Inhalers BUDESONIDEfor for inhalation Asthma or COPD New Zealand March 2016 powder for inhalationFLUTICASONE powder for inhalationpropionate Aerosol inhalers FLUTICASONESubsidisedAerosol inhalers propionateSubsidised Inhalers for Inhalers Asthma for or Asthma COPD Newor COPD Zealand New ZealandMarch 2016 March 2016 50mcg/dose 100mcg/dose50mcg/dose dipropionateparticle 100mcg/dose Aerosol Aerosol inhaler inhaler 100mcg/dosedipropionate Ultrafine 200mcg/dose powder for inhalation 50mcg/dose 125mcg/dose powder for inhalation particle Aerosol inhaler 100mcg/dose50mcg/doseICS Inhaler Devices Identification Chart – 200mcg/dose Inhaled Corticosteroids 125mcg/dose 250mAerosolcg/dose inhalers 50mcg/dose 125mcg/dose 250mcg/dose 50mcg/dose50mcg/dose 100mcg/dose 100mcg/dose particle Aerosol400mcg/dose inhaler 100mcg/dose 200mcg/dose 50mcg/dose 125mcg/dose SABA 250m250mcg/dose cg/dose– Short-Acting 50mcg/dose Beta2 125mcg/doseAgonists 250mcg/dose 50mcg/dose 100mcg/dose 400mcg/dose 50mcg/dose 125mcg/dose 250mcg/doseSABA – Short-Acting250mcg/dose Beta2 Agonists BECLOMETHASONE250mcg/dose BECLOMETHASONE BUDESONIDE FLUTICASONE propionate 50mcg/dose 100mcg/dose 400mcg/dose FLUTICASONE propionate 250mcg/dose nebuliser dipropionate Aerosol inhaler dipropionate Ultrafine powder for inhalation powder for inhalation SALBUTAMOL nebuliser solution SALBUTAMOLAerosolSALBUTAMOL Aerosol inhalers inhaler Aerosol inhaler TERBUTALINETERBUTALINE powder for powder inhalation for inhalation 50mcg/dose 100mcg/dose particle Aerosol inhaler 100mcg/dose 200mcg/dose 50mcg/dose 125mcg/doseShort Acting Muscarinic Combination SABA + 2.5mg/2.5mL2.5mg/2.5mL nebule nebule 50mcg/doseShort Acting Beta2 Agonists (SABA) 100mcg/puff 125mcg/dose 100mcg/puff 250mcg/dose 250mcg/dose250mcg/dose 250mcg/dose 50mcg/dose 100mcg/dose 400mcg/dose 250mcg/doseAntagonists (SAMA) SAMA 5mg/2.5mL5mg/2.5mL nebule nebule SALBUTAMOL IPRATROPIUM SALBUTAMOL + IPRATROPIUM

Beclazone QVar Pulmicort Turbuhaler Floair Flixotide Flixotide Accuhaler Beclazone QVar Pulmicort Turbuhaler Floair Flixotide Flixotide Accuhaler Beclazone QVar Pulmicort Turbuhaler Floair Flixotide Flixotide Accuhaler

RELIEVERS Budesonide is approximately Beclazone and QVar are NOT dose equivalent: Budesonide is approximatelyFluticasone and beclomethasone dipropionate are NOT dose equivalent Beclazone and QVar are NOT dosethe equivalent: same potency as standardBudesonide is approximately Fluticasone and beclomethasone dipropionate are NOT dose equivalent QVar is approximately twice as potentBeclazoneBeclazone as standard and QVar are NOT doseSubsidisedQVarSubsidised equivalent:Subsidised Inhalers Inhalers Inhalers thefor for AsthmasamePulmicort for Asthma Asthmapotency or FluticasoneTurbuhaler COPDor orCOPD as COPDNew standard New isZealand New approximately ZealandMarch ZealandMarch March 2016Floair 2016 twice2016 Fluticasone as potent as and sta beclomethasonendardFlixotide beclomethasone dipropionate dipropionateFlixotide are AccuhalerNOT dose equivalent beclomethasone dipropionatethe same potency100mcg as standard 100mcgFluticasone is100mcg approximately 100mcg twice as potent as250mcg standard beclomethasone dipropionate20mcg 100/20 QVar is approximately twice as potent as standard Fluticasone is approximately twice as potent as standard beclomethasone dipropionate beclomethasone dipropionateQVar (Beclazone) is approximately twice as potent as standardICS beclomethasoneICS–Budesonide InhaledRespigenICS – Inhaled – Inhaled Corticosteroids is Corticosteroids approximately CorticosteroidsRespigen dipropionate SalAir SalAir(Beclazone) Salamol Salamol Ventolin Ventolin Bricanyl TurbuhalerBricanyl Turbuhaler Asthalin Asthalin beclomethasoneBeclazone and dipropionate QVar are NOT (Beclazone) dose equivalent:(Beclazone) beclomethasoneRespigen dipropionate SalAirFluticasone andVentolin beclomethasone Salamol dipropionate (Beclazone)Bricanyl Turbuhaler are NOT dose equivalent Atrovent Duolin HFA beclomethasone dipropionate (Beclazone) the same (Beclazone)potency as standard (Beclazone) BECLOMETHASONEBECLOMETHASONEQVarBECLOMETHASONE is approximately BECLOMETHASONE twiceBECLOMETHASONEBECLOMETHASONE as potent as standard BUDESONIDE BUDESONIDEBUDESONIDE (Beclazone) Fluticasone is approximatelyFLUTICASONE twiceFLUTICASONEFLUTICASONE as potent propionate propionate as propionate sta ndard beclomethasone dipropionate beclomethasone dipropionateFLUTICASONEFLUTICASONE FLUTICASONE propionate propionate propionate Inhaled Corticosteroids (ICS) dipropionatedipropionatedipropionate beclomethasoneAerosol Aerosol Aerosol inhaler inhaler inhaler dipropionate dipropionate dipropionatedipropionate Ultrafine (Beclazone) Ultrafine Ultrafine powder powderpowder for inhalation for forinhalation inhalation powder powder powder for inhalation for forinhalation inhalation AerosolAerosolAerosol inhalersFLUTICASONE propionate inhalers inhalers (Beclazone) Combination ONCE BECLOMETHASONE BECLOMETHASONE 50mcg/dose50mcg/dose50mcg/dose 100mcg/dose (see 100mcg/dose 100mcg/dosenote 3) particle particleparticle Aerosol Aerosol Aerosol inhaler inhaler inhaler 100mcg/dose 100mcg/dose 100mcg/dose 200mcg/dose 200mcg/dose 200mcg/dose (Beclazone) 50mcg/dose50mcg/dose50mcg/dose 125mcg/dose 125mcg/dose 125mcg/dose BUDESONIDE Combination ICS & LABA 50mcg/dose50mcg/doseFully50mcg/dose subsidised 125mcg/dose 125mcg/dose -125mcg/dose Special Authority 250m cg/dose 250m cg/dose 250m cg/dose removed Combination ONCE dipropionate (ultra fine particle) 250mcg/dose250mcg/dose250mcg/dose 50mcg/dose50mcg/dose50mcg/dose 100mcg/dose 100mcg/dose(see 100mcg/dose note 3) 400mcg/dose400mcg/dose400mcg/dose Aerosol inhaler and A Fully subsidisedccuhaler - Special 250mcg/dose250mcg/dose 250mcg/doseAuthority removed Combinationdipropionate ONCE (see note 3) CombinationCombinationSAMA ICS ICS & – LABA &Short-ActingSAMA LABA – Short-Acting FullyMuscarinic subsidised Muscarinic - AntagonistsSpecial Authority Antagonists dailyremoved (see ICS note & 3) LABA (see note 3) CombinationCombination SABA & SAMASABA & SAMA(see note 3) (see note 3) Combination daily ONCE ICS & LABA (see note 3) daily ICS & LABA BUDESONIDE WITH FLUTICASONE Combination PROPIONATE ICS& & LABA Fully subsidised - Special Authority removed & BUDESONIDEBUDESONIDE WITH WITH FLUTICASONE PROPIONATEFLUTICASONE & SALMETEROL PROPIONATE & daily ICS FLUTICASONE& LABA SALBUTAMOL FUROATESALBUTAMOL & WITH IPRATROPIUM WITH IPRATROPIUM SALBUTAMOLSALBUTAMOL WITH IPRATROPIUM WITH IPRATROPIUM FORMOTEROL BUDESONIDE WITH BUDESONIDE WITH FORMOTEROLAerosol inhalerFLUTICASONE PROPIONATE & SALMETEROLIPRATROPIUM IPRATROPIUM Nebuliser solutionVILANTEROL Nebuliser solutionFLUTICASONE FUROATE & powder for inhalation BUDESONIDE WITH FORMOTEROL FLUTICASONEFLUTICASONE PROPIONATE PROPIONATE & & FORMOTEROLBUDESONIDE WITH IPRATROPIUMFLUTICASONEIPRATROPIUM Aerosol PROPIONATEAerosol inhaler Aerosol inhaler & SALMETEROL inhalerSALMETEROL FLUTICASONE FUROATEVILANTEROL & Aerosol inhalerAerosol inhaler Nebuliser solutionNebuliser solution FORMOTEROL Aerosol inhaler Aerosol inhaler BUDESONIDEpowder for WITH inhalation FORMOTEROL50mcg fluticasone propionate & FLUTICASONE 250PROPIONATE mcg/mLpowder &250 mcg/mL for inhalation FORMOTEROL powder for inhalation SALMETEROLSALMETEROL VILANTEROL Aerosol inhaler AerosolAerosol inhaler inhaler powder for inhalation 20mcg/puff50mcg50mcg fluticasone 20mcg/puff fluticasone propionate propionatepowder & for & inhalation powder forfor inhalationinhalationsalbutamol salbutamol100 mcg + 100 mcg + salbutamolsalbutamol 2.5 mg + 2.5 mg + budesonide 100 mcg & budesonide 100Beclazone mcg & QVar Pulmicort25mcg Turbuhaler salmeterol/puff Floair Flixotide SALMETEROLFlixotidepowder Accuhaler forFluticasone inhalation furoate 100mcg & AerosolBeclazone Beclazoneinhaler QVar QVar PulmicortPulmicort Turbuhaler Turbuhaler 50mcg50mcg 125mcg 250mcgFloair fluticasone Floair propionate 50mcg 125mcg 250mcgFlixotide & Flixotide 50mcgFlixotide 100mcg 250mcgFlixotide 500mcg/2mLAccuhalerpowder Accuhaler for inhalation100mcg 500mcg/2mL 200mcg powder 400mcg for inhalation 50mcg 100mcg 250mcg 50mcg 100mcg budesonidebudesonide 100 mcg 100 & mcgbudesonide & budesonide 100 mcg 100 & mcg & 25mcg25mcg salmeterol/puff salmeterol/puff100mcg fluticasone propionatepowder for & inhalation vilanterol 25 mcg Fluticasone furoateipratropium 100mcg100mcg & & ipratropium 20 mcg /puff 20 mcg /puff ipratropiumipratropium 500 mcg /2.5 500 mL mcg /2.5 mL 6 mcg formoterol /dose 6 mcg formoterol /dose budesonide 400 BudesonideBudesonide125mcgBudesonide is approximately isfluticasone approximately is approximately propionate & Fluticasone furoate 100mcg & budesonide 100 mcg & budesonide 100 mcg & 25mcg FluticasoneFloair salmeterol/puff and beclomethasone Flixotide dipropionate Flixotide Accuhaler are100mcg NOT 100mcgdose equivalent fluticasone fluticasone Pulmicort Turbuhaler propionate propionate & & Beclazone Qvar 6 mcg formoterolBeclazoneBeclazone Beclazone/dose and and QVar 6and QVar mcgare QVar NOTare formoterol areNOT dose NOT dose equivalent: dose equivalent: /doseequivalent: budesonide 400 125mcgFluticasone Fluticasonefluticasone and beclomethasone and propionate beclomethasone50mcg dipropionate salmeterol/dose & dipropionate 100mcg are NOT dose fluticasone are equivalent NOT dose equivalent propionate ( Asthma& and COPD) vilanterol 2525 mcgmcg 6 mcg formoterol /dosemcg 6 mcg& formoterol formoterol /dosethe same the thesamebudesonide potency same25mcg potency potency as standard assalmeterol/puff 400standard as standard 125mcg fluticasone propionate & vilanterol 25 mcg 6 mcgQVarQVar formoterolis QVarapproximately is approximately is approximately /dose twice twice6 as mcgtwice potent as formoterolpotent as aspotent standard as standard as /dosestandard budesonide 400 Fluticasone125mcgFluticasoneFluticasone fluticasoneis approximately is approximately is approximately propionate twice twice as twice potent & as potent as aspotentndard sta asndard sta asbeclomethasonendard sta beclomethasone beclomethasone50mcg50mcg dipropionate dipropionate salmeterol/dose dipropionatesalmeterol/dose (Asthma and COPD) beclomethasonemcgbeclomethasone beclomethasone& formoterol dipropionate dipropionate dipropionate 25mcg salmeterol/puff250mcgCombination Inhaled fluticasone propionate50mcg salmeterol/dose & Fluticasone s (ICS) + Long Acting Beta2 Agonist furoate(Asthma 200mcg and COPD&(Asthma ) and COPD) s (LABA) budesonide 200 mcg & budesonidebeclomethasone 200beclomethasone beclomethasone mcg & dipropionate dipropionate12 dipropionate mcg/dose (Beclazone) (Beclazone) (Beclazone) mcgNotmcg &subsidised: formoterol & formoterol 250mcg fluticasone25mcg25mcg salmeterol/puff salmeterol/puff (Beclazone)(Beclazone)(Beclazone) (Beclazone)(Beclazone)(Beclazone) FLUTICASONE propionate + SALMETEROL50mcg salmeterol/dose250mcg 250mcgfluticasone250mcg fluticasone fluticasonepropionateFLUTICASONE furoate propionate& vilanterolpropionate Fluticasone 25 & & mcg furoate Fluticasone 200mcg furoate & BUDESONIDE + FORMOTEROL 200mcg200mcg & & PREVENTERS budesonidebudesonidebudesonide 200 mcg 200 200 & mcgmcgbudesonide & budesonide 200 200mcg 200 mcg & mcg & & 1212 mcg/dose 12mcg/dose mcg/dose NotNot subsidised:Not subsidised: subsidised: 250mcg 250mcg 250mcg fluticasone fluticasone fluticasone 6 mcg formoterol /dose 6 mcg formoterol /dose propionate & 25mcg salmeterol/puff Aerosol inhaler and Accuhaler50mcg salmeterol/dose50mcg50mcg salmeterol/dose salmeterol/dose + VILANTEROL(Asthma onlyvilanterol) 25 mcgvilanterol 2525Turbuhaler and Aerosol inhal mcgmcg er 6 mcg formoterol6 mcg6 mcg formoterol formoterol /dose /dose/dose6 mcg 6 formoterol mcg formoterol formoterol /dose /dose /dose propionatepropionatepropionate & 25mcg & 25mcg & salmeterol/puff25mcg salmeterol/puff salmeterol/puff CombinationCombinationCombination ONCE ONCE ONCE (Asthma only ) (see note(see(see 3)note note 3) 3) Fully subsidised - Special Authority removed ((AsthmaAsthma onlyonly) ) Combination CombinationCombination ICS ICS& LABAICS & LABA & LABA Fully subsidisedFully subsidised - Special - AuthoritySpecial Authority removed removed dailydaily ICSdaily ICS& LABAICS & LABA& LABA BUDESONIDEBUDESONIDE WITH WITH FLUTICASONE PROPIONATE & SALMETEROL FLUTICASONEFLUTICASONE FUROATE FUROATE & & BUDESONIDE WITH BUDESONIDE WITH FORMOTEROL FLUTICASONEFLUTICASONE PROPIONATE PROPIONATE & SALMETEROL & SALMETEROL FLUTICASONE FUROATE & BUDESONIDEBUDESONIDE WITH FORMOTEROL WITH FORMOTEROL FLUTICASONEFLUTICASONEFLUTICASONE PROPIONATE PROPIONATE PROPIONATE & & & FORMOTEROLFORMOTEROLFORMOTEROL AerosolAerosolAerosol inhaler inhaler inhaler VILANTEROLVILANTEROLVILANTEROL powderpowderpowder for inhalation for forinhalation inhalation SALMETEROLSALMETEROLSALMETEROL AerosolAerosolAerosol inhaler inhaler inhaler 50mcg50mcg fluticasone fluticasone propionate propionate & & powderpowder powder for inhalation for forinhalation inhalation 50mcg fluticasone propionate & powder for inhalation powder powder for inhalation for inhalation Fluticasone furoate 100mcg & Vannair budesonidebudesonidebudesonideSymbicortVannair 100 100mcg 100 mcg& Turbuhaler budesonidemcg & budesonide & budesonide 100 100mcg 100 mcg&Symbicort mcg & & TurbuhalerRexAir 25mcg25mcg salmeterol/puff25mcg salmeterol/puff Atroventsalmeterol/puff 50/25 125/25 250/25 RexAirSeretide Atrovent 50/25 125/25 250/25 Seretide Seretide AccuhalerFluticasone 100/50 Seretide Fluticasone furoate Accuhaler250/50Univent furoate100mcg 100mcg & Univent100/25 &Breo Ellipta200/25 Breo Ellipta 100/6 200/6 400/12 100/6 200/6Duolin Duolin Duolin Duolin 100mcg100mcg100mcg fluticasone fluticasone fluticasone propionate propionate propionate & & & vilanterol 25 mcg 6 mcg formoterol /dose 6 mcg formoterol /dose budesonide 400 125mcg125mcg fluticasone fluticasone propionate propionate & & vilanterolvilanterol 25 mcg 25 mcg 6Vannair mcg formoterol6 mcgVannair formoterol /dose 6 /dosemcg formoterol6 mcg formoterolSymbicort /dose Symbicort budesonide/dose Turbuhalerbudesonide Turbuhaler400 400 125mcg fluticasone propionateRexAirRexAir & 50mcg salmeterol/doseSeretideSeretide SeretideSeretide Accuhaler Accuhaler BreoBreo ElliptaEllipta Inhaler presentations Inhalerare RexAir NOT presentations dose50mcg equivalent salmeterol/doseare50mcg NOTSeretide Seretide Accuhaler salmeterol/dose with dose Accuhaler equivalent ( Asthma with(Asthma Accuhaler(Asthma and andCOPD and COPD) COPD) ) FluticasoneBreo EllipFluticasone furoateta furoate Symbicort Turbuhaler Vannair Note 12mcg mcg mcg& formoterolmcg & formoterol & formoterol Note 12mcg 25mcg 25mcg salmeterol/puff25mcg salmeterol/puff salmeterol/puff Budesonide is half as potent as Budesonidefluticasone is half as potent as fluticasone Inhaler presentations250mcg250mcg fluticasone fluticasone are propionate NOTpropionate dose & &Fluticasone equivalent Fluticasone furoate furoatewith 200mcgAccuhaler 200mcg & & Fluticasone furoate budesonide 200 mcg & budesonide 200 mcg & 12 mcg/doseInhalers containNot subsidised: 25mcgInhalers 250mcg salmeterol fluticasone containInhaler - 25mcg presentations Accuhalers250mcg salmeterol fluticasone con are tain propionate- AccuhalersNOT 50mcg dose & salmeterolFluticasone conequivalenttain 50mcg furoate with salmeterol 200mcg Accuhaler & 100mcg ONCE100mcg daily ONCE Fluticasonedaily furoate budesonidebudesonide 200 mcg 200 & budesonidemcg & budesonide 200 mcg 200 & mcg12 & mcg/dose 12 mcg/dose formoterol/doseNote Not subsidised: 12mcgNot subsidised: 250mcg©Respiratory Quality Improvement Group, June 2016 250mcg fluticasone fluticasone vilanterol 25 mcg Vannair® 100/6 is equivalentBudesonide toBudesonide SymbicortVannair® is half 100/6 isas half potent is equivalentasformoterol/dose potent as fluticasone to as Symbicort fluticasone Note 12mcg 50mcg50mcg salmeterol/dose50mcg salmeterol/dose salmeterol/dose vilanterolvilanterol 25 mcg 25 mcg Stabilisers 6 mcg6 mcgformoterol6 mcg formoterol formoterol /dose /dose6 /dosemcg 6 mcgformoterol6 mcg formoterol formoterol /dose /dose /dose Inhaler:propionate TWOpropionatepropionate puffs & 25mcg & 25mcgtwice &Inhalers salmeterol/puff25mcgInhaler: Inhalerssalmeterol/puff daily; salmeterol/puff containTWO contain Accuhaler: puffs 25mcg twice 25mcg ONEdaily;salmeterol salmeterol in halationAccuhaler: - Accuhalerstwice- ONE Accuhalers in dailyhalation (conAsthma con twicetaintain only 50mcg daily 50mcg) is approx.salmeterol salmeterol Mast equivalentis approx. Cell equivalent to Stabilisers 100mcg to ONCEONCE dailydaily Vannair® 100/6Turbuhaler®100/6. is equivalent to Symbicort formoterol/doseMaximumformoterol/dose 1 dose (Asthma(Asthma only) only) Turbuhaler®100/6.Vannair® 100/6 is equivalentMaximum to Symbicort 1 dose If extra inhaledInhaler: corticosteroid TWO puffs is needed, twice daily;change t oAccuhaler: the higher strengthONE inhalation presentation twice daily fluticasone propionateis approx. equivalent to Usual dose 1 or 2 inhalations twice daily If extra inhaledtwice daily corticosteroid SODIUMInhaler: is needed, TWO CROMOGLYCATE change puffs t otwice the higher daily; Powder strength Accuhaler: for presentation inhalation ONE inhalation twicefluticasone daily propionateSODIUM CROMOGLYCATEis approx. equivalent Aerosol to inhaler Aerosol inhaler Usual dose 1 or 2 inhalations twiceTurbuhaler®100/6. dailyTurbuhaler®100/6. MaximumMaximum 1SODIUM dose 1 dose CROMOGLYCATE or Powder add separate for inhaledinhalation corticosteroid SODIUM CROMOGLYCATE250mcg TWICE daily Aerosol inhaler NEDOCROMIL Aerosol inhaler twice daily If extra inhaled corticosteroid is needed, change ot the higher strength presentation fluticasone propionate Usual dose 1 or 2 inhalations twice daily orIf extraadd separate inhaled inhaledcorticosteroid corticosteroid20mg/dose is needed, change to the higher strength250mcg presentation TWICE daily fluticasone5mg/puff propionate 2mg/puff Usual dose 1Prepared or 2 inhalations by Helen Cant Clinical twice Pharmacist daily Tokoroa Marchtwice 2016.twice Disclaimer: daily daily This information is obtaine20mg/dosed from current relevant sources; individual clinical circumstances should be considered when making treatment5mg/puff decisions. 2mg/puff or add separate inhaled corticosteroid 250mcg TWICE daily Prepared by Helen Cant Clinical Pharmacist Tokoroa March 2016. Disclaimer: This information is obtained from current relevant sources; individualor add clinica separatel circumstances inhaled should corticosteroid be considered when making treatment decisions. 250mcg TWICE daily

PreparedVannairPrepared Vannairby VannairHelen by Cant Helen Clinical Cant Symbicort PharmacistClinicalSymbicortSymbicort Pharmacist Turbuhaler Tokoroa Turbuhaler Turbuhaler Tokoroa March March 2016. 2016.Disclaimer:RexAir Disclaimer:RexAir ThisRexAir information This informationSeretide isSeretide obtaineSeretide is obtaine d from d from currentSeretide currentSeretide relevantSeretide Accuhaler relevant Accuhaler sources; Accuhaler sources; individual individual clinicaBreo clinicaBreol Elliptacircumstancesl Breocircumstances Ellipta Ellipta should should be be considered considered when when making making tr treatmenteatment decisions.decisions. Inhaler presentations are NOT dose equivalent withAccuhaler Fluticasone furoate Note 12mcg Inhaler Inhalerpresentations presentations are NOT are dose NOT equivalent dose equivalent withAccuhaler withAccuhaler FluticasoneFluticasone furoate furoate BudesonideBudesonideBudesonide is half is halfas is potenthalf as potent as aspotent fluticasone as fluticasone as fluticasone Note 12mcgNote 12mcg Inhalers contain 25mcg salmeterol - Accuhalers taincon 50mcg salmeterol 100mcg ONCE daily formoterol/dose InhalersInhalers contain contain 25mcg salmeterol25mcg salmeterol - Accuhalers - Accuhalerstain con 50mcgtain con salmeterol50mcg salmeterol 100mcg100mcg ONCE daily ONCE daily Vannair®Vannair®Vannair® 100/6 100/6 is 100/6 equivalent is equivalent is equivalent to Symbicort to Symbicort to Symbicort formoterol/dose formoterol/dose Inhaler:Inhaler:Inhaler: TWO TWO puffs TWO puffs twice puffs twice daily; twice daily; daily;Accuhaler: Accuhaler: Accuhaler: ONEhalation ONE inhalation ONE inhalation twice in twice daily twice daily daily is approx. is approx.is approx. equivalent equivalent equivalent to to to Turbuhaler®100/6.Turbuhaler®100/6.Turbuhaler®100/6. MaximumMaximumMaximum 1 dose 1 dose 1 dose If extraIf extra inhaledIf extra inhaled inhaledcorticosteroid corticosteroid corticosteroid is needed, is needed, is needed, change changeo the changet o higherthe to thehigher t strength higher strength strength presentation presentation presentation fluticasone fluticasonefluticasone propionate propionate propionate UsualUsual doseUsual dose 1 ordose 12 orinhalations 1 2 or inhalations 2 inhalations twice twice daily twice daily daily twice daily twice dailytwice daily or add separate inhaled corticosteroid 250mcg TWICE daily or add separateor add separate inhaled inhaledcorticosteroid corticosteroid 250mcg250mcg TWICE dailyTWICE daily PreparedPrepared Preparedby Helen by Helen Cantby Helen ClinicalCant Cant Clinical Pharmacist Clinical Pharmacist Pharmacist TokoroaMarch Tokoroa TokoroaMarch 2016. March 2016. Disclaimer: 2016. Disclaimer: Disclaimer: This information This Thisinformation information is obtaine isd obtainefrom isd obtaine fromcurrentd from current relevant current relevant sources; relevant sources; individual sources; individual individualclinical circumstances clinical circumstances clinical circumstances should should be shouldconsidered be considered be considered when when making when makingeatment tr makingeatment tr decisions.eatment tr decisions. decisions. Intal SpincapsIntal & Spinhaler Spincaps & Spinhaler Intal Forte Intal Forte Tilade Tilade

Prepared by HelenPrepared Cant Clinical by Helen Pharmacist Cant Clinical Tokoroa Pharmacist March Tokoroa 2016. Disclaimer: March 2016. This Disclaimer: information This is obtaine informationd from is obtaine current drelevant from current sources; relevant individual sources; clinica individuall circumstances clinica l circumstances should be considered should be when considered making whentr eatment making decisions. tr eatment decisions. Subsidised Inhalers for Asthma or COPD New ZealandMarch 2016 LABA – Long Acting Beta2 Agonists (see note 3) ‘Ultra’ long-acting beta2 Subsidised Inhalers for Asthma or COPD New ZealandMarch 2016 For asthma, MUST be used in combination with an inhal ed corticosteroid refer http://www.nzf.org.nz/nzf_1706 agonist (see note 3) (see note 3) LABA – Long Acting Beta2 Agonists ‘Ultra’ long-acting beta2 SALMETEROL SALMETEROL FORMOTEROL (eformoterol) (see note 3) For asthma, MUST be used in combination with an inhal ed corticosteroid refer http://www.nzf.org.nz/nzf_1706 agonistFORMOTEROL (eformoterol) Aerosol inhaler Powder for inhalation 6mcg/dose powder for powder for inhalation SALMETEROL SALMETEROL FORMOTEROL (eformoterol) 12mcg/doseINDACATEROL powder for inhalation 25mcg/dose 50mcg/dose FORMOTEROL (eformoterol)inhalation 150 mcg/dose or 300 mcg/dose Aerosol inhaler Powder for inhalation 6mcg/dose powder for powder for inhalation 12mcg/dose powder for inhalation 25mcg/dose 50mcg/dose inhalation 150 mcg/dose or 300 mcg/dose

Foradil capsule containing powder for Onbrez capsules containing powder Meterol Serevent Serevent Accuhaler Oxis Turbuhaler inhalation via Aerolizer device for inhalation via Breezhaler device Foradil capsule containing powder for Onbrez capsules containing powder Meterol Serevent InhalerSerevent presentations Accuhaler are NOT doseOxis equivalent Turbuhaler with Accuhaler Indication - COPD inhalation via Aerolizer deviceOxis and Foradil for inhalationare NOT dosevia Breezhaler equivalent device Subsidised Inhaler Inhalers - 25mcg for salmeterol/puff; Asthma or COPD Accuhaler New - 50mcgZealandsalmeterol/dose March 2016 Oxis contains 6mcg/dose 150mcg OR 300mcg Inhaler presentations are NOT dose equivalent withAccuhaler Oxis and Foradil are NOT dose equivalent Indication - COPD Inhaler - 25mcg salmeterol/puff; AccuhalerAerosol - 50mcg inhalersalmeterol/dose TWO puffs twice daily Accuhaler(see note ONE3) nhalation i twice daily Foradil contains 12mcg/capsule150mcg OR for 300mcg inhalation inhaled via Breezhaler ONCE daily LABA – Long Acting Beta2 Agonists Oxis contains 6mcg/dose ‘Ultra’ long-acting beta2

AerosolFor inhaler asthma, TWO MUST puffs be used twice in daily combination Accuhaler with ONE an nhalationiinhal ed corticosteroid twice daily refer http://www.nzf.org.nz/nzf_1706Foradil contains 12mcg/capsule for inhalation agonist (see noteinhaled 3) via Breezhaler ONCE daily LAMA – Long Acting Muscarinic No Special Authority required for umeclidinium or glycopyrronium – Special Authority required for Tiotropium see Note 1 SALMETEROL SALMETEROL FORMOTEROLLAMA – Long (eformoterol) Acting Muscarinic (see note 3)INDACATEROL script must be endorsed that patient has had COPD confirmed by spirometry see Note 1 FORMOTEROL (eformoterol)AntagonistNo Special Authoritys required for umeclidinium or glycopyrronium – AerosolSpecial inhaler Authority required for TiotropiumPowder for inhalation 6mcg/dose powder for(see note 3) powder for inhalation Antagonists 12mcg/dose powderscript for inhalationmust be endorsed that patient has had COPD confirmed by spirometry 25mcg/dose 50mcg/dose TIOTROPIUM inhalation SubsidisedSubsidisedTIOTROPIUM InhalersSubsidised Inhalers for InhalersAsthma for Asthma orfor COPD Asthma150 or mcg/dose New COPD or ZealandCOPD orNewUMECLIDINIUM 300 New mcg/doseZealand March Zealand 2016March March 2016 2016 GLYCOPYRRONIUM TIOTROPIUM Powder forTIOTROPIUM inhalation 18mcg/dose solution for inhalationUMECLIDINIUM 2.5mcg/inhalation powder for inhalationGLYCOPYRRONIUM 62.5mcg/dose powder for inhalation 50mcg/dose Subsidised Inhalers forLABA Asthma – LongLABA or COPDLABA Acting – Long New– LongBeta2 Acting Zealand Acting Agonists Beta2 March Beta2 Agonists 2016 Agonists (see note 3) (see note(see 3) note 3) ‘Ultra’ long-acting‘Ultra’ ‘Ultra’ long-acting beta2long-acting beta2 beta2 Powder for inhalation 18mcg/dose solution for inhalation 2.5mcg/inhalation powder for inhalation 62.5mcg/dose powder for inhalation 50mcg/dose (see note 3) For asthma, MUST be used in combination with an inhal(seeed notecorticosteroid 3) refer http://www.nzf.org.nz/nzf_1706 (see note(see 3) note 3) LABAFor asthma, –For Long asthma, MUSTActing MUST be Beta2 used be inusedAgonists combination in combination with anwith inhal an edinhal corticosteroid ed corticosteroid refer http://www.nzf.org.nz/nzf_1706refer http://www.nzf.org.nz/nzf_1706‘Ultra’ long-acting beta2 agonist agonistagonist

For asthma, MUST be used in combination with an inhal ed corticosteroid refer http://www.nzf.org.nz/nzf_1706 agonist (see note 3) SALMETEROLInhaler Devices Identification ChartSALMETEROL SALMETEROL SALMETEROLSALMETEROL SALMETEROL FORMOTEROL FORMOTEROL (eformoterol)FORMOTEROL (eformoterol) (eformoterol) INDACATEROLINDACATEROL INDACATEROL Foradil capsule containing powder for Onbrez capsules containingFORMOTEROL FORMOTEROLpowder (eformoterol)FORMOTEROL (eformoterol) (eformoterol) Meterol Serevent SALMETEROLSerevent Accuhaler Aerosol inhalerAerosol SALMETEROLAerosolOxis inhaler Turbuhaler inhaler PowderFORMOTEROL forPowder inhalation (eformoterol)Powder for inhalation for inhalation 6mcg/dose 6mcg/dose powder6mcg/dose for powder powder for for INDACATEROL powder forpowder inhalationpowder for inhalation for inhalation inhalationLong Acting Beta2 Agonists (LABA) via Aerolizer deviceFORMOTEROL (eformoterol)for inhalation via12mcg/dose Breezhaler powder device for inhalation Aerosol inhalerSpiriva capsule containingPowder powderfor inhalation for 6mcg/dose powder for 12mcg/dosepowder12mcg/dose for inhalationpowder powder for inhalation for inhalation Seebri capsules containing powder for inhalation 25mcg/dose25mcg/dose SALMETEROL Aerosol inhaler and Accuhaler25mcg/dose 50mcg/dose 50mcg/dose 50mcg/dose FORMOTEROL (eformoterol)12mcg/dose inhalation powder inhalation for inhalationinhalation INDACATEROL 150 mcg/dose150 mcg/doseor150 300 mcg/dose mcg/dose or 300 or mcg/dose 300 mcg/dose Inhaler Spirivapresentations capsule are containing NOT dose powder equivalent25mcg/dose for withAccuhaler 50mcg/dose inhalationSpiriva Respimat SeebriIndication capsules Incruse- COPD150 containing mcg/dose Ellipta or powder 300 mcg/dose for inhalation inhalationSpiriva via Handihaler Respimat deviceOxis and Foradil are NOT doseIncruse equivalent Ellipta via Breezhaler device Inhaler - 25mcginhalation salmeterol/puff; via Handihaler Accuhaler device - 50mcg salmeterol/dose OxisAdult contains dose: 6mcg/dose 2 puffs (5mcg) ONCE daily Indication150mcg – COPD: OR 300mcg viaONE Breezhaler dose inhaled device ONCE daily AdultAdult dose:dose: 18mcg2 puffs (5mcg)inhaled ONCE ONCE daily daily Indication – COPD: ONE dose inhaled ONCE daily Indication – COPD: 50mcg inhaled ONCE daily Aerosol inhalerAdult TWO dose: puffs 18mcg twice daily inhaled Accuhaler ONCE dailyONE nhalationi twice daily Foradil contains 12mcg/capsule for inhalation inhaled viaIndication Breezhaler – COPD: ONCE 50mcgdaily inhaled ONCE daily

see Note 2 (see note 3) see Note 2 Special Authority required (see note 3)LAMA – Long 25mcg 25mcg 50mcg Acting Muscarinic Combination 6mcg 12mcg LAMA & ‘ultra’ long-acting Special150mcg 300mcg Authority beta2 required agoni st (LABA) see Note 1 Combination LAMA & ‘ultra’ long-actingNo Special Authoritybeta2Foradil agoni required capsulest (LABA)for containingumeclidinium powder or gforForadillycopyrronium OnbrezcapsuleForadil capsules –Foradilcontaining capsule containingcapsule containing powder containing powder for powder powderOnbrez for for capsules Onbrez Onbrez containing capsules capsules containing powder containing powder powder Special Authority required for TiotropiumMeterol MeterolSerevent Meterol MeterolMeterol Serevent Serevent Accuhaler SereventSerevent (see noteAccuhaler 3)Serevent Serevent Serevent Oxis AccuhalerTurbuhalerSereventSerevent Accuhaler Oxis Turbuhaler Foradil Aerolizer device Accuhaler Oxis TurbuhalerOxis TurbuhalerOxis Turbuhaler Onbrez Breezhaler TIOTROPIUMAntagonist BROMIDEs WITH OLODATEROLscript must be endorsed thatinhalation patientUMECLIDINIUM via has Aerolizer had COPD device WITH con firmed VILANTEROLinhalation byfor spirometryinhalation inhalationvia Aerolizerinhalation via Breezhaler via deviceAerolizer via deviceAerolizer device deviceforGLYCOPYRRONIUM inhalation for inhalationviafor Breezhaler inhalation WITH via Breezhaler devicevia INDACATEROL Breezhaler device device WITH UMECLIDINIUM WITH VILANTEROL Combination Long Acting Muscarinc Antagonists (LAMA) GLYCOPYRRONIUM WITH INDACATEROL Long Acting Muscarinic Antagonists (LAMA) TIOTROPIUM solutionInhaler for inhalation presentationsTIOTROPIUM areInhaler NOT dosepresentationsInhaler equivalentInhaler solutionpresentations arewith presentations NOT Accuhalerfor doseinhalation are NOTequivalent arepowder doseUMECLIDINIUMNOT equivalentdose with for equivalent inhalationAccuhaler withOxis and Accuhalerwith Foradil Accuhaler are NOT dose+ Long Acting Beta2 Agonists (LABA) equivalentOxispowder andGLYCOPYRRONIUM ForadilOxis for inhalationandOxis are Foradil andpowderNOT Foradil dose are for NOT equivalent areinhalationIndication doseNOT equivalentdose - COPD equivalent IndicationpowderIndication - forCOPD inhalationIndication - COPD - COPD Inhaler - 25mcg salmeterol/puff; Accuhaler - 50mcg salmeterol/dose Oxis contains TIOTROPIUM + 6mcg/dose UMECLIDINIUM + GLYCOPYRRONIUM + 150mcg OR 300mcg Powder for inhalationTiotropium 18mcg/dose 2.5mcg solution with olodaterol for inhalation Inhaler 2.5mcg 2.5mcg/inhalation - Tiotropium25mcg Inhaler Inhalersalmeterol/puff; - 25mcg 2.5mcg - TIOTROPIUM25mcg salmeterol/puff;Umeclidinium with salmeterol/puff; Accuhalerpowder olodaterol for Accuhaler- 50mcg62.5 inhalationUMECLIDINIUM Accuhaler2.5mcg mcg salmeterol/dose - 50mcgwith 62.5mcg/dose - 50mcgvilanterolGLYCOPYRRONIUM salmeterol/dose salmeterol/dose 25 mcg Umeclidinium powder 62.5glycopyrronium forOxis mcg inhalation contains withOxis vilanterol50mcg/dose 6mcg/dose 50containsOxis mcg contains with 6mcg/dose25 mcg indacaterol 6mcg/dose 110 mcg glycopyrronium 150mcg 50 OR mcg150mcg 300mcg with150mcg OR indacaterol 300mcg OR 300mcg 110 mcg Foradil contains 12mcg/capsuleOLODATEROL for inhalation VILANTEROL INDACATEROL Aerosol inhaler TWO puffsAerosol twice inhaler Aerosoldaily Accuhaler AerosolTWO inhaler puffs inhaler ONE TWO twice i nhalation TWOpuffs daily puffstwice Accuhalertwice twice daily daily dailyAccuhalerONE Accuhalerinhalation ONE iONE nhalationtwice inhalation daily twice twice daily daily Foradil containsForadilForadil 12mcg/capsule contains contains 12mcg/capsuleinhaled 12mcg/capsulefor inhalationvia Breezhaler for inhalation for ONCE inhalation daily inhaled viainhaled Breezhalerinhaled via Breezhaler ONCE via Breezhaler daily ONCE ONCE daily daily SYMPTOM CONTROLLERS

see Note 1 LAMA – Long Acting Muscarinic No Special Authority required for umeclidinium or g lycopyrronium – Special Authority required for Tiotropium (see noteLAMA 3) –LAMA LongLAMA Acting – Long – LongMuscarinic Acting Acting Muscarinic Muscarinic No SpecialNo Authority SpecialNo Special requiredAuthority Authority for required umeclidinium required for umeclidinium for or umeclidinium glycopyrronium or glycopyrronium or g –lycopyrronium – – Antagonist see Note 1 sees Note see 1 Note 1 script must be endorsed that patient has had COPD con firmed by spirometry Special AuthoritySpecial Special Authorityrequired Authority for required Tiotropium required for Tiotropium for Tiotropium (see note 3) (see note(see 3) note 3) Antagonist AntagonistsAntagonist s s script mustscript be endorsedscript must mustbe endorsedthat be patient endorsed that has patient that had patient COPD has had con has COPDfirmed had COPD con by firmedspirometry confirmed by spirometry by spirometry TIOTROPIUM TIOTROPIUM GLYCOPYRRONIUM Spiriva capsule containing powder for 18mcg 2.5mcg 62.5mcg 50mcgUMECLIDINIUM Seebri2.5/2.5 capsulesUltibro containing62.5/25 capsule powder containing for50/110 inhalation powder for inhalation Ultibro capsule containing powder for inhalation SpioltoPowder forRespimat inhalationSpiriva 18mcg/dose RespimatTIOTROPIUM solutionSpiriva Handihaler Spiriva RespimatTIOTROPIUM for SpioltoTIOTROPIUM inhalation Respimat 2.5mcg/inhalation IncruseIncruse ElliptaAnoro TIOTROPIUM Ellipta Ellipta powder Seebri BreezhalerTIOTROPIUM TIOTROPIUM for inhalation 62.5mcg/dose Spiolto AnoroAnoroUMECLIDINIUM ElliptaEllipta powderUMECLIDINIUM Ultibro BreezhalerUMECLIDINIUM for inhalation 50mcg/dose GLYCOPYRRONIUMGLYCOPYRRONIUMGLYCOPYRRONIUM inhalation via Handihaler device via Breezhaler devicevia Breezhaler device via Breezhaler device Indication COPD: TWOAdult inhalations dose: 2 puffsPowder ONCE (5mcg) dailyforPowder inhalation ONCE Powder NOTESfor daily inhalation18mcg/dose for inhalationIndication 18mcg/doseIndication 18mcg/dosesolution – COPD: COPD: for ONEsolution ONEinhalation dosesolution inhalation for inhaled inhalation2.5mcg/inhalation for inhalation ONCEONCE 2.5mcg/inhalation daily daily 2.5mcg/inhalation powder forpowder inhalationpowder for inhalation62.5mcg/dose for inhalation 62.5mcg/dose 62.5mcg/dose powder forpowder inhalationpowder for inhalation50mcg/dose for inhalation 50mcg/dose 50mcg/dose Adult dose: 18mcg inhaled ONCE daily Indication •COPD: Beclazone and Qvar are NOT dose equivalent TWO inhalations ONCE daily IndicationIndication COPD: – COPD: IndicationONE 50mcg inhalation inhaledCOPD: ONCE ONEONCE inhalation dailydaily ONCE daily • Fluticasone furoate 100mcg DAILY is approximately equivalent to fluticasone propionate 250mcg BD Indication COPD: ONE inhalation ONCE daily • Breo Ellipta 200/25 is not subsidised Prepared by Helen Cant Clinical Pharmacist TokoroaMarch 2016. Disclaimer:• Symbicort 400/12 and Seretide This information Accuhaler 100/50 and 250/50 can not be prescribed as greater than 2 doses per day is obtained from current relevant sources; individual clinical circumstances should besee considered Note 2 when making treatment decisions. (see note 3) Prepared by Helen Cant Clinical Pharmacist TokoroaMarch 2016. Disclaimer: This information Special isAuthority obtained from required current relevant sources; individual clinical circumstances should be considered when making treatment decisions. Combination LAMA• The therapeutic dose of tiotropium when delivered via Respimat device (Spiriva Respimat or Spiolto & ‘ultra’ long-acting beta2 agonist (LABA) ) is 5microgram daily ie. two doses inhaled once daily Spiriva capsule containing powder for • Tiotropium (handihaler and respimat) – require Special Authority SA1568 (Actual FEV 1 as a % of predicted <60%) Seebri capsules containing powder for inhalation TIOTROPIUM BROMIDE WITH OLODATEROL UMECLIDINIUM• Glycopyrronium Spiriva –Respimat Subsidy by endorsement WITH VILANTEROL “certified condition” or “COPD confirmed by spirometry” Incruse ElliptaGLYCOPYRRONIUM (post FEV1/FVC < LLN WITHor <0.7) INDACATEROL inhalation via Handihaler device via Breezhaler device solution for inhalation Adult• dose:Umeclidinium 2 puffs– Subsidy b (5mcg)y endorsement ONCE daily “certified condition” or “COPD confirmed by spirometry” Indication – COPD: ONE dose (post bronchodilator FEV1/FVC < LLN inhaled ONCEpowder daily for orinhalation <0.7) Adult dose: 18mcg inhaledSpiriva ONCE capsule dailySpiriva Spirivacontaining capsule• capsule Prescribing Combination LAMA + LABA containing powderpowder containing for forpowder inhalation powder for- all combinations (Spiolto, Anoro Ellipta, Ultibro) require Special Authority SA1584 (same form for all for combinations)Indication – COPD: 50mcg inhaled ONCESeebri daily capsules SeebriSeebri containing capsules capsules containing powder containing for powder inhalation powder for inhalation for inhalation *Inhalers not depicted include Mast Cell Stabilisers including: SODIUM CROMOGLYCATE powder for inhalation (Intal Spincaps andSpiriva RespimatSpirivaSpiriva Respimat Respimat spinhaler 20mg/dose) and aerosol inhaler (Intal Forte 5mg/puff) and Incruse ElliptaIncruse Incruse Ellipta Ellipta Tiotropium 2.5mcg with olodaterol 2.5mcg inhalation inhalationviaUmeclidinium HandihalerinhalationNEDOCROMIL aerosol inhaler (Tilade 2mg/puff) via Handihaler devicevia 62.5 Handihaler mcg device with device vilanterol 25 mcg glycopyrronium 50 mcg with indacaterol 110 mcg via Breezhalervia Breezhaler devicevia Breezhaler device device Adult dose:Adult 2 puffs Adultdose: (5mcg) dose:2 puffs ONCE 2 puffs(5mcg) daily (5mcg) ONCE ONCE dailyIndication daily Indication– COPD:Indication ONE – COPD: dose – COPD: ONEinhaled doseONE ONCE inhaleddose daily seeinhaled NoteONCE 2 ONCE daily daily (see note 3) Special Authority required Adult dose:Adult 18mcg Adultdose: inhaled dose:18mcg ONCE18mcg inhaledCombination daily inhaled ONCE ONCE daily LAMA daily & ‘ultra’ long-acting beta2 agoni st (LABA) Indication Indication– COPD:Indication 50mcg – COPD: –inhaled COPD: 50mcg ONCE50mcg inhaled daily inhaled ONCE ONCE daily daily TIOTROPIUM BROMIDE WITH OLODATEROL©Respiratory Quality Improvement Group, June 2016 UMECLIDINIUM WITH VILANTEROL GLYCOPYRRONIUM WITH INDACATEROL see Note 2 see Notesee 2 Note 2 solution for inhalation (see note 3) (see note(see 3) note 3) powder for inhalation Special Authority Special Special Authorityrequired Authority required required Combinationpowder forCombination inhalationCombination LAMA & LAMA ‘ultra’ LAMA & long-acting ‘ultra’ & ‘ultra’ long-acting beta2long-acting agoni beta2 beta2st agoni(LABA) agonist (LABA)st (LABA) Tiotropium 2.5mcg with olodaterol 2.5mcg Umeclidinium 62.5 mcg with vilanterol 25 mcg glycopyrronium 50 mcg with indacaterol 110 mcg TIOTROPIUMTIOTROPIUM BROMIDETIOTROPIUM BROMIDEWITH BROMIDE OLODATEROL WITH WITH OLODATEROL OLODATEROL UMECLIDINIUMUltibro capsuleUMECLIDINIUMUMECLIDINIUM WITH containing VILANTEROL WITH powder WITH VILANTEROL for VILANTEROL inhalation GLYCOPYRRONIUMGLYCOPYRRONIUMGLYCOPYRRONIUM WITH INDACATEROL WITH WITH INDACATEROL INDACATEROL Spiolto Respimat Anoro Ellipta solution forsolution inhalationsolution for inhalation for inhalation powder forviapowder inhalationBreezhalerpowder for inhalation devicefor inhalation powder forpowder inhalationpowder for inhalation for inhalation Indication COPD: TWO inhalations ONCE daily TiotropiumIndication 2.5mcg COPD:with olodaterol ONE inhalation 2.5mcg ONCE daily glycopyrronium 50 mcg with indacaterol 110 mcg TiotropiumTiotropium 2.5mcg 2.5mcg with olodaterolwith olodaterol 2.5mcg 2.5mcg UmeclidiniumIndicationUmeclidinium 62.5Umeclidinium mcg COPD: with62.5 ONE vilanterol mcg62.5 inhalation with mcg vilanterol25with mcgONCE vilanterol daily25 mcg 25 mcg glycopyrroniumglycopyrronium 50 mcg 50 with mcg indacaterolwith indacaterol 110 mcg 110 mcg

Prepared by Helen Cant Clinical Pharmacist TokoroaMarch 2016. Disclaimer: This information is obtained from current relevant sources; individual clinical circumstances should be considered whenUltibro making capsule treatment containing decisions. powder for inhalation Spiolto Respimat Anoro Ellipta via Breezhaler device Indication COPD: TWO inhalations ONCE daily Indication COPD: ONE inhalation ONCE daily

Indication COPD: ONE inhalation ONCE daily Prepared by Helen Cant Clinical Pharmacist Tokoroa March 2016. Disclaimer: This information is obtaine d from current relevant sources; individual clinica l circumstances should be considered when making tr eatmentUltibro decisions. capsule Ultibro Ultibrocontaining capsule capsule containing powder containing for powder inhalation powder for inhalation for inhalation Spiolto RespimatSpioltoSpiolto Respimat Respimat Anoro ElliptaAnoro Anoro Ellipta Ellipta via Breezhalervia Breezhaler devicevia Breezhaler device device Indication IndicationCOPD:Indication TWO COPD: inhalations COPD: TWO TWOinhalations ONCE inhalations daily ONCE ONCE daily daily Indication IndicationCOPD:Indication ONE COPD: inhalation COPD: ONE inhalationONCEONE inhalation daily ONCE ONCE daily daily Indication IndicationCOPD:Indication ONE COPD: inhalation COPD: ONE inhalationONCEONE inhalation daily ONCE ONCE daily daily

Prepared by HelenPrepared CantPrepared by Clinical Helen by PharmacistCant Helen Clinical Cant Tokoroa Clinical Pharmacist Pharmacist March Tokoroa 2016. Tokoroa MarchDisclaimer: March2016. This Disclaimer: 2016. information Disclaimer: This isinformation obtaine This informationd from is obtaine current is obtained fromrelevant dcurrent from sources; current relevant individual relevant sources; clinica sources; individuall circumstances individual clinical clinica circumstances shouldl circumstances be considered should shouldbe when considered be making considered when treatment making when decisions. making treatment tr eatment decisions. decisions.