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Home , CYR61, HBx, Micrococcal nuclease, RecQ helicase

(2002) 21, 9079 – 9093 ª 2002 Nature Publishing Group All rights reserved 0950 – 9232/02 $25.00 www.nature.com/onc

Volume 21 keyword index

1,3-butadiene 5643 Adenine nucleotide Alternative first Anti-neoplastics 9 13q21 6567 translocator 1963 6007 Anti-neovascular therapy 14-3-3s 2418, 3207, 8310, Adenocarcinoma 158, Alternative lengthening 2662 1876 5804, 5814, 7831 of telomeres 598 Antiangiogenesis 4558 2-acetylaminofluorene Adenoma 5814 Alternative splicing 2768, Antibod(ies) 1304, 5725, 1945 Adenoma-carcinoma 3029 7114 2-deoxyribonolactone sequence 4120 Alternatively-spliced p53 Anticancer activity 3162 8926 Adenomatous polyps 5117 Anticancer drugs 4317, 2-methyoxyestradiol 7175 AML 4247 4885 4149 Adenovirus 87, 1411, AML1 2695, 3232, 3247, Antiestrogen 7147 2’-methoxyethyl RNA, 4757, 6278, 8011, 8428 Antiestrogen-resistance telomere 631 8340 AML1/ETO 3422 8178 3p12 tumour suppressor Adenovirus therapy AMLI/Evi-1 2695 Antiestrogens 8158 gene 3020 3688 AMP-activated Antigen 3879, 8668 3’-phosphoglycolate 8926 Adenovirus vector 2108, kinase (AMPK) 6082 Antisense 87, 2890, 3162, 4-disulphide core 2768 2493 Amplification 909, 2261, 8011 5-aza-2’-deoxycytidine Adherens junction(s) 7593 Antisense oligodeoxy- 5496 7067, 7642 A-MuLV 8568 nucleotides 4166 5-azacytidine 5483 Adhesion 8272, 8605, A-Myb 1859 Antisense RNA 5127 5-lipoxygenase 5765 8683 Anaplastic lymphoma Antisense technology 7,8-dihydro-8-oxoguanine Adhesion molecule 3089 kinase (ALK) 5823 4932 (8-oxoG) 8232 Adipose tissue 1679 Anchorage 1777 AP 8905, 8-hydroxyguanine 1649 Adrenomedullin 2815 Anchorage independence 8926 8-oxoguanine 8905 Afadin 2545, 4108 3969 AP1 738 8oxo G/A mismatch 5204 3872 Anchorage independent AP-1 2181, 3121, 3836, Aging 494, 4363 growth 217, 2365 4266, 5923, 6317, 6434, A2B adenosine receptor 5574 Androgen receptor 2679, 7680, 8186 4663 AIBI 7147 5069, 5609, 8453 AP-1 complex 2971 A3 adenosine receptor AIDS 3592, 7464 Androgen regulated AP-2 7478 4060 AIF 65 8749 Apaf-1 1469, 1848 A431 2670 Akt 53, 207, 329, 337, Androgen-regulated 4738 Apc 6446 avb6 intergrin 1370 1062, 1159, 1299, 1727, Aneuploidy 6146 APC 4646, 4696, 6387, Abl 6848 1945, 1955, 3532, 4032, 272, 427, 8340 ABL 8536 5224, 7131, 7797, 8683, 2058, 2245, 2433, 2504, APC hyper- Acanthoma 6446 8871 2815, 3172, 3541, 3889, 7981 Acetyl-CoA carboxylase AKT 1391, 6255 4765, 5951, 6307, 8128, Ape1 protein 8926 6729 AKT1 198 8506 Aphidicolin 5929, 7226 Acetylation 1556, 2741 ALCL 1038 Angiogenic factor 8477 Apigenin 3727 8428 Alcohol 1539 Angiostatin 272 Aplidin 7533 Actin 96 Alcohol intake 1225 Animal model(s) 2089, Apo2L 5763 Actin polymerization Alcoholic liver disease 32 3445, 9033 Apo2L/TRAIL 3611 5967 Alkylating agent(s) 878, Ankryin 5255 1, 9, 32, 44, Actin rearrangement 1108, 5940 Annexin I 6641 65, 140, 190, 227, 260, 1477 All-trans retinoic acid Anoikis 2161, 2365, 2908, 319, 329, 337, 377, 532, Activator protein-1 738 7147 6801, 7797, 8001 592, 656, 748, 778, 878, Active or open Allele-specific 5753 Anoxia 4212 947, 1017, 1028, 1038, nucleosomes 1649 Allelic imbalance 5975, Ansamycins 1159 1071, 1135, 1171, 1233, Activin 2227 8878 Antagonistic pleiotrophy 1251, 1285, 1299, 1335, Acute lymphoblastic Allelic loss(es) 5016, 7605 503 1359, 1381, 1469, 1563, leukemia 3225 Allelotyping 1461 Anti-apoptotic genes 1600, 1668, 1685, 1727, Acute promyelocytic ALT 522 4166 1750, 1759, 1848, 1882, leukemia 3496 ALT-associated PML Anti- therapy 8786 1963, 1989, 2020, 2141, adCMV- 4613 bodies 598 Anti- 4000 2171, 2245, 2283, 2295, Volume 21 keyword index

9080 2413, 2441, 2484, 2534, BAD 329 Betaig-h3 7471 Breast carcinoma(s) 2613, 2623, 2775, 2829, BADD45 5335 bFGF 809 3241, 4317 2890, 2919, 2981, 2991, BAG-1 isoforms 7050 BH3 3181 Breast neoplasms 8506 3011, 3082, 3112, 3121, Bak 227 Big BlueTM 7126 Breast tumor(s) 3532, 3139, 3149, 3181, 3213, Barrett’s cancer 3780 Bik 227 8529 3260, 3284, 3459, 3532, Barrett’s esophagus 475 BIK 2534 Breast- 3727, 3765, 3796, 3836, Barrett’s oesophagus Bile acids 6740 6841 3872, 3917, 3925, 4042, 6071 Bile duct cancer 4301 Brn-3a 6123 4149, 4323, 4335, 4392, Barrier function 3765 Bim 4944 Bronchoscopy 6949 4473, 4481, 4539, 4558, Basal cell carcinoma Bioinformatics 475, 8029 BTEB 2212 4613, 4691, 4702, 4715, 5529 Biological classification BTG2TIS21/PC3 6772 4757, 4801, 4944, 4957, Base excision 8905 8206 bTrCp 856, 1501, 3978 5038, 5047, 5160, 5268, Biomarker(s) 6870, 7598 Burkitt cell line 4473 5716, 5835, 5844, 5886, 5204, 8675 Bisindolylmaleimide-I Butyrate 6340 5897, 5934, 5951, 6091, BATF 8186 6348 6113, 6123, 6132, 6278, bax 990 Bisulphite genomic C3H/10T1/2 8196 6299, 6458, 6510, 6598, bax 6458 sequencing 1048 c-Abl 974 6606, 6649, 6772, 7050, Bax 32, 1963, 2020, 3139, BK virus 5725 Cadherin 2545, 4108, 7195, 7514, 7524, 7861, 3149, 4009, 4530, 4757, Bladder cancer 650, 2476, 7642 7901, 8020, 8114, 8149, 6032, 7050 4894 Cadherins and catenins 8223, 8240, 8361, 8379, b-catenin 856, 2679, Bloom’s syndrome 954, 6071 8404, 8414, 8568, 8591, 4099, 4863, 5861, 5906, 2079, 2525, 9008 Calcium 2762 8804, 8843 7861, 7971,8293, 8340, B-lymphoma 1922 Calcium signaling 7839 APRT 2840 8414, 8453 BMP-2 7156 Calponin 7720 A-Raf 347 b-catenin activation 5548 B-Myb 1859, 7923 cAMP 778, 4020, 4060 ARE 2191, 5301 b catenin Bone tumors 1141 Camptothecin 7913, 8361 ARF 2939, 5960 7981 B-Raf kinase 6356 Cancer 494, 564, 598, Aromatase 2854 B-cell lymphoma 8173 Brain 3939 1309, 3089, 3917, 4435, Arsenic trioxide 3496 B cell markers 4908 Brain tumor(s) 878, 1141, 5380, 5394, 5400, 5414, Arylhydrocarbon B cell phenotype 4166 2058, 5038, 8372 5483, 5496, 5951, 6071, receptor 6059 B cells 3855 BRC repeat 1130 6082, 6140, 6154, 6175, Asbestos 1434, 7284, B-cell neoplasia 7235 BRCA 6729 6234, 7307, 7656, 7749, 7471 bcl-2 6458 BRCA1 1401, 3199 8741, 8862, 9033 ASK 7786 Bcl2 4530 Brca1 4747, 5097 Cancer development 1679 Asparagine 5891 BCL2 7765 BRCA1 4171, 6222, Cancer diagnosis 475 Astrocytoma 1325, 4050 Bcl-2 32, 1548, 2020, 7034, 7730, 8981, Cancer predisposition Ataxia-telangiectasia 849, 3898, 4549, 4613, 4944, 8994 9008 3864, 4363 5047, 5313, 5897, 7050, BRCA1 mutations 6841 Cancer prevention 6113 ATF 7824 7611, 8149 BRCA1-associated Cancer specific ATF-2 1000 Bcl-2 cleavage 2141 surveillance complex 708 ATF3 7488 Bcl-2 family 748, 2762 4788 Cancer-chemoprevention ATL 2466 BCL6 gene 368 BRCA2 1130, 5188, 3663 ATM 483, 532, 611, 849, BCL-family 708 5660, 8981, 8994 Cancer-related protein 1090, 4191, 4363, 6377, Bcl-x 1668 BRCT 6729 4932 6633, 7776 Bcl-xl 6510 Break-induced 688 ATRA 5224 Bcl-xL 1038, 2775, 2908, replication 522 Capping 532, 627 Attachment 4765 5182, 7765 108, 227, Carboplatin 2805 Aurora 6175 BCR/ABL 8536 460, 761, 836, 964, Carcinogenesis 2750, Aurora-B 3103 BCR 8536 1009, 1316, 1832, 2066, 3780, 4728, 5462, 6870, Auto-antibody 5006 Bcr 4601 2261, 2270, 2365, 2704, 8272, 8895 Auto-antigen 5006, 5946 BCR/ABL 5868, 8547, 2854, 3172, 3517, 3934, Carcinogens 7435 Autocrine 108, 6540, 8577, 8605 4000, 4080, 4171, 4307, Carcinoid 8310 8817 BCR – ABL 3068, 4351, 4422, 4521, 4626, 4680, Carcinoma cell 7514 Autocrine TGFb 7514 8612, 8629 4747, 4921, 5047, 5127, Casein kinase II 5280 Autocrine transforming Bcr – Abl 8075, 8804, 5148, 5175, 5462, 5619, CASP8 8510 growth factor a 2785 8541, 8560 5654, 5696, 6366, 6567, Caspase 377, 748, 809, Autoimmunity 5593 Bcr – Abl protein 8584 7034, 7147, 7557, 7680, 1251, 1299, 2020, 2534, 6606 Bcr/Abl P190 3225 7850, 8158, 8178, 8843 4613 AXIN1 4863, 7981 BCR/ABL rearrange- Breast cancer cell(s) Caspase-3 2108, 7050, AXIN2 4863, 7981 ment 5716 5765, 7730 8047, 8414 Axl 329 Beta-catenin 6598, 6983 Breast cancer model 890 Caspase-8 2295, 6132

Oncogene Volume 21 keyword index

9081 Caspase-9 2141 CDNA microarrays 475, Cellular localization 6766 11q13 5631 Caspase-10 2919 4855 Cellular 503 Chromosome 12q21 3029 Caspase 10 4129 CDT1 1150 Central-nervous-system Chromsome 13 6567 Caspase cleavage 867 Cdt1 6624 neoplasm 239 2097 Caspase-independent CEA 7817 Centriole 6146, 6201 Chromosome 18 5016 6091 C/EBP 3377 890, 5097, Chromosome 20 2768 Caspases 65, 1017, 1242, C. elegans 6201 6140, 6154, 6161, 6175, Chromosome 22q 6480 1848, 2283, 2623, 4089, 1450, 3889, 6184, 6195 Chromosome instability 4530, 5160, 5313, 6032, 7656, 8612 Centrosome 4673, 5654, 6140, 6884 6132, 6649, 6809, 7533, Cell attachment 8470 amplification 6222, Chromosome segregation 8843 140, 437, 447, 6228 7507 Caspases, DN-caspase 9 708, 1359, 1485, 1493, Centrosome duplication 1548, 1717, 1750, 1934, 6201, 6209 translocation 6703 Catalase 5886 2741, 2750, 3247, 3525, Centrosome hyper- 2051 Catenin 4108, 7042, 7656 3651, 3796, 4328, 4539, amplification 6234 Chronic myelogenous Cathepsin B 8705 4626, 4680, 4978, 5313, 6241 leukemia (CML) 8560, Cathepsin-D 5127, 5951 5515, 5773, 5897, 6059, Ceramide 44, 2020, 4009 8668 Cathepsin L 7839 6146, 6403, 6530, 6573, Cervical cancer 165, Cidofovir 2334 Catnb 5643 6722, 7230, 7545, 7630, 5631, 6241, 8713 Cigarette smoke(ing) Caveolin 1658, 2365 7765, 7850, 7901, 7923, Cervix neoplasia 665 7326, 7392, 7435 CBC 5649 8001, 8067, 8158, 8282, c-FLIP 6809 CIMP 2741 CBF 3247 8320, 8804 c-fos 2721 Circadian clock 9043 CBFb 3422 Cell cycle arrest 5912, c-Fos 4843 Circulating cancer cells Cbl 1707, 5346 7569 c-fos repression 719 7817 CBL-B 1423 Cell cycle checkpoint(s) CGH 158, 1518 Cisplatin 5935, 6713, CBP 2253, 2455, 7241 2079, 4191, 6884 CGH analysis 6877 7131, 8361, 8723 CBP/p300 1028 Cell cycle progression Chaperone activity 1123 c-Jun 2441, 7077 CCK-2R 7656 5245 Checkpoint(s) 1633, c-Jun N-terminal kinase CCND1 1928 Cell cycle regulated 2328, 6249, 8591 2154 CD30 2493 protein 1123 Chemoprevention 3727, c-Jun phosphorylation CD31 4558 Cell cycle regulation 6779 7945 2154 CD44 1196 Cell death 809, 1963, Chemoresistance 7611, CK2 3978 CD9 2584 8262 8683 CK20 7817 CD95 165, 1600, 4042, Cell differentiation 2347, Chemosensitivity 1 c-kit 3068 6809 6772 Chemotherapy 260, 6059 c-kit 4508 CD95/Fas 190 Cell dispersion 1477 CHFR 2328 CLCP1 2822 cdc2 6425 Cell growth 1658, 2029, Chk2 1316, 6633 Clb5 2051 CDC25B 7630 3784, 7891, 8498 Choline kinase 937, 4317 Cleavage by caspase-3 Cdc25C 1717, 6633 Cell invasion 8240 Chromatic structure 5358 5024 CDC42 3939 Cell line 2114, 4646 719, 2741, Clinical application 6868 Cdc6 1777 1423, 8470 5361, 6403 Clonality 2466, 3274 CDH1 8192 Cell morphology 6779, Chromatin remodeling Clonogenic survival 5935 CDH1 1928 6801 1196 Cluster analysis 4855 cdk 7765 Cell motility 4089, 6520 Chromosomal Clusterin 4328 CDK 8089 Cell proliferation 2201, abnormality(ies) 1679, c-Maf 5301 CDK4 2476 3889, 5529 2525 c-Met 1000, 1791 cdk inhibitors 4680, Cell scattering 2347 Chromosomal instability c-Met tyrosine kinase 6573 Cell shape 4843 619, 825, 3253, 6146 1477 cdk2 6573 Cell survival 207, 1062 Chromosomal CML 3068, 8541, 8547, Cdk2 6154, 8397, 8529 Cell transformation 248, rearrangements 7671 8577, 8584, 8605, 8612, CDK4 4277, 8067, 8852 4838, 7497 Chromosomal 8629, 8643, 8804 Cdk6 1777 Cell viability 6017 translocation 1309 c-myb 3076 CDK6 4277 Cell-cycle arrest 3727, Chromosome 1 2261 c-Myb 1859 cdk9 4137, 4158, 5797 6123 Chromosome 3 4521 c-myc 1600, 2097, 3414, Cdkn2a 5960 Cell-surface proteolysis Chromosome 4 1225 4384, 5280, 6848 CDKN2A 8878 3765 Chromosome 4 5135 c-Myc 909, 1518, 2981, CDKs 6413 Cell – cell adhesion 2719, Chromosome 4p 8356 3011, 6559, 6819, 7872, cDNA array 3095, 5804 8414 Chromosome 6q21 7266 8414 cDNA arrays 4587, 4957 Cell – cell junctions 1477, Chromosome 8p 1461 c-Myc induction 7137 cDNA macroarray 2926, 2545 Chromosome 11p15.5 Co-activators 5773 2270, 2634, 4120, 8521 Cell-cycle 1685 2564 Co-carcinogenesis 7392

Oncogene Volume 21 keyword index

9082 Co-transcriptional factor Crkl 8536 Cytogenetics 6877 Diffuse gastric cancer 861 Crkl, Ph-positive 3225 Cytokeratin expression 8192 Coactivator 7147 Cross-antagonism 3368 5548 Diffuse large B-cell Cross-talk 4000 Cytokine network 3284 lymphoma 368 3571, 8675, 8949 Crypt 5441 Cytokine receptor(s) Dihydrofolate reductase Coding mononucleotide Crystallin 1028 3579, 6264, 7464 2981 repeats 5081 CSB 8232 Cytokine(s) 2201, 3295, Diphosphorylation 5852 Coiled-coil 4422 c-Src 1071 4384, 8568, 8871 DISC 6809, 8510 Collagen gels 5148 CT element 7187 Cytology 643 Disease gene 7247 Collagenase 1187 CtBP 2695 Cytoplasm 1493 Distinct gene profiles Colon 8741 CtBP1 3232 Cytoplasmic epoxide 2926 Colon cancer 1370, 1443, Culture 7897 8521 Dkc1 deficient mice 7740 4120, 4646, 4855, 4992, Curcumin 8414, 8852 Cytoskeleton 96, 1171, Dlg 8140 5861, 6032, 6387, 7256, Cyanide 282 3969, 5255 DMBT1 5956 7797, 7817, 8340 Cyclin A 5791 Cytotoxicity 5213, 6264 DN-caspase 9 4530 Colon carcinoma 1450, Cyclin A2/Cdk2 7923 DNA adducts 7376 2785, 3688, 4997 Cyclin B 2051 DN-p53 6722 DNA binding 981, 1563, Colorectal cancer 1928, Cyclin B1 6751, 8282, D-Loop 3780 2119, 5117 3253, 5441, 6740, 7175, 8696 DAP kinase 1217, 4231 DNA 7901 7277, 7585, 8477 Cyclin D 1159, 5791 Dbf4 7786 DNA breakage 2141 Colorectal carcinoma Cyclin D1 198, 291, 307, Dbl 4601 DNA damage 356, 553, 5081, 5906, 6689 1590, 1928, 2212, 5515, DDA3 3050 592, 611, 974, 5844, Combination therapy 7545, 8067, 8852 Death and survival genes 5912, 6614, 7435, 7488, 5868 Cyclin D1 phosphory- 4957 7776, 8591, 8723 Common fragile sites lation 7214 Death domain 4691 DNA damage repair 8713 Cyclin D2 7214 Death receptor 5 6032 4481 Common virus Cyclin D3 1777 Death receptors 319, DNA damage tolerance integration site 7247 Cyclin D1 promoter 8001 2623, 3121, 6649 8957 Companion animals Cyclin dependent Decorin proteoglycan DNA double-strand tumours 1785 kinase(s) 1750, 5031, 3688, 4765 break 6884 Comparative genomic 6908 Degradation 2387 DNA double-strand hybridization 1117 Cyclin E 291, 4626 DEK 8862 break repair 4176 Competitive PCR 1097 Cyclin E/Cdk2 7923 Deletion 479, 1167, 4521 DNA glycosylase(s) 8886, Complex translocation Cyclin E1 8529 Deletion 7q 4849 8905 4706 Cyclin E2 8529 Deletion in p53 4042 DNA hypermethylation Conditional knockout Cyclin T2 4158 Deletion mapping 6915 6694 4635 Cyclin-cdk 8114 Demethylation 789 DNA hypomethylation Confocal microscopy Cyclin-dependent Denys-Drash syndrome 2564, 6694 7710 kinase(s) 5773, 6779 2948 DNA injection 3696 Connexin 32 4992 Cyclin-dependent p21 DEP1 7067 DNA instability 3571 Connexin 43 1989, 4992 kinases 3403 Dephosphorylation 1870 DNA interstrand cross- Constitutive activation Cyclin(s) Cyclin 1263, Desmoplastic small link 5188 78, 5891 1493, 4137, 4680, 6154, round cell tumor 2009 DNA methylation 1048, Constitutive phosphory- 8089 Detoxifying genes 2191 3659, 3804, 3909, 4822, lation 5823 Cyclo-oxygenase-2 411, Development 2880 5358, 5361, 5380, 5388, Contact inhibition 5990 6113 Dexamethasone 1346 5400, 5414, 5427, 5462, Conversion 6328 Cyclobutane pyrimidine DHBV 6606 5483, 5496, 9033 COX-2 7092 dimmer 5743 dHPLC 5016 DNA CpG island methylation Cyclooxygeanse 7175 Diagnosis 643, 650, 5450, 4822, 5361, 5483, 5496, 2114 Cyclopentenone 2212 6960 7883 CpG island(s) 1048, Cyclophilin 2261 Diagnostic imaging 6949 DNA microarray(s) 437, 3659, 3804, 5427, 5450 Cyr61 964, 8178 Diethynitrosamine 1791 6848 CpG methylation 1876, Cystathionine beat Differential expression DNA mismatch repair 8878 synthase 6848 4932, 7598 1768, 5081, 5743, 7126 CPT-11 3611 Cystatin C 8705 Differentiation 128, 1527, DNA photorepair 9043 CRE 5923 Cysteine 2191 1600, 1859, 2880, 2971, DNA polymerase b 2320 Cre 6446 Cyteine-proteases 8843 3068, 3260, 3262, 3377, DNA repair 437, 1401, c-Rel 8759 Cytochrome c 377, 1242, 3403, 3414, 3739, 4289, 1633, 4065, 5188, 5204, Cre-loxP system 3445 1848, 2775, 3139, 4613, 4747, 5268, 7933 5335, 5394, 5654, 5940, Cre-loxP 4521 5844 Differentiation therapy 6471, 7901, 8232, 8591, Cre/lox 899 Cytochrome-P450 6059 3496 8886, 8935, 8981, 9022

Oncogene Volume 21 keyword index

9083 DNA replication 437, E-cadherin 1928, 3241, Endothelial cell Erythropoiesis 400, 1556, 909 3631, 4231, 4646, 6049, proliferation 844 2641, 2864 DNA replication check- 8192 Endothelial cell(s) 2058, ES oncoprotein 1695 point 7710 E1A 44, 329, 1028, 2534, 3552, 4200, 7027 ESET 148 DNA replication fidelity 7991 1309, 2433 Esophageal cancer 411, 8895 E1A and ras Enhanced transactivation 475, 1208, 5024, 7745 DNA synthesis 5929 719 5704 EST1 522 DNA II E2A 6559 Environmental tobacco Estradiol 964 4706 437, 1359, 2939, smoke 6870, 7341 761, 836, 1097, DNA tumor virus 3207 3784, 4220, 4539, 5835, Eosophageal squamous 5233, 7680, 7730 DNA-PK 6471 6498, 7569 cell carcinoma 6641 Estrogen-dependence DNA-binding 990 E2F-1 2376, 3715, 6278 Eph kinase 7690 8178 DNA-PK 532 E2F1 1563, 4414 Eph receptor tyrosine Estrogen receptor a 4921, DNA-repair 731, 3663 E2F4 1563 kinase 7011 5233 Dominance 1641 E3-ubiquitin 3677 7011 Estrogen receptor(s) Dominant negative 2695, E3L 8379 Epidemiology 7326 4000, 4317, 7034, 7730, 5990 E5 248, 7808 Epidermal growth factor 8158 Dominant negative E6 1510, 2605, 2961, 460, 2161, 4738, 6520 ESX 3934 mutants 2425 5665, 8140 Epidermal growth factor Etk 8817 Dominant negative E6 – E7 oncogenes 419 receptor 2846 ETS 2309 STAT3 4778 E7 oncogenes 1510 Epidermal keratinocyte Ets 3934 Double fusion 4181 Early detection 5462 738 ETS factors Double minute EBNA-1 5182 Epidermis 4266 2890 chromosomes (DMs) EBNAZA 1263 Epigenetic modification Ets-1 7933 825, 890 Ebp1 5609 4822 ETV6-NTRK3 5684 Double strand break EBV 4166, 4473, 5182 Epigenetic(s) 3864, 4345, ETV6/ARG 4374 1401, 8967 EBV transforming genes 5358, 5394 EVI1 3232 Double strand break 4166 Epithelial cells 1590, Ewing family tumor(s) DNA repair 2525 Eck 7690 2161, 7656 3847, 8302 Double-strand break ECM 8011 Epithelial proliferation Ewing tumor 307 repair 7671 eed 299 4900 Ewing’s sarcoma 809, Double translocation EGF 119, 4071 Epithelium 1527 3847, 7700 4181 EGF receptor 5038, 8723 Epithelium-mesenchyme EWS 1890 Down-regulated protein EGF-R 4812 transition 2347 EWS-ETS 8302 6641 EGFP 4508 erbA 4307 EWS/FLI 3847 Downregulation 7131 EGFR 4032, 6255 ErbB 460, 2066, 4032, EWS – WT1 2009 Downstream target genes EGR-1 3391 6530 Exchange factor 7720 8196 EKLF 3368 ErbB receptors 5609 2130 Doxorubicin 5160, 6132, Ela 7131 ErbB1 2584 Exonuclease activity 5117 8020 Elafin 2768 erb-B-2 8732 Expression 7749 Doxycycline 272 Elk-1 719, 6434 erb B2/neu 2805 Expression analysis 1832 DR4 3121, 3611 Elongation phase 3715 ErbB2 78, 3934, 4567, Expression profile 4120 DR5 3611 EMAST 4894 6255, 6573, 7042, 7524 Expression profiling DRIP205 861 Embryonal carcinoma erb-B-3 8732 2948, 5566, 7256 Drosophila 2413, 4812, 1739, 2880 ErbB3 8442 Extinction 4908 6458 Embryonic stem cell ErbB4 8442 8506 Drug resistance 227, 5504, 5515 ERBIN 7042 Extracellular regulated 4595, 8020, 8843 EMMPRIN 5765 ERG 148 kinase 5515 Drug targets 8786 EMT 5148 Erk 1/2 8871 Extracellular signal Drugs 2295 End-joining fidelity Erk 22 regulated kinase 5601 DSRCT 1890 1401 ERK 307, 1978, 2309, Eye 1841 dsRNA 8379 Endocrine tumors 7605 5923 DT40 954 Endogenous erk 6413 FADD 319, 4129 DT40 cells 3076 5593 ERK activation 347 FAK 96, 2513, 3969, DU 145 cells 4009 2815, Erk1/2 6255 6488, 6992 Dunning tumor 2089 3517, 7981 ERK2 1370 Falkor 6713 DUTT1/ROBO1 Endonuclease V 1909 Error-prone DNA repair Fanconi an(a)emia 2406, 3020 8957 4873, 5002 1493 ER-stress 2623 Farnesylation 5998 564, 7740 Endoplasmic reticulum Erythroleukemia 1272, Farnesyltransferase Dyskerin 7740 stress response 8749 1859, 3562 inhibitor (FTI) 7883

Oncogene Volume 21 keyword index

9084 Fas 1600, 4129, 4702, Fyn 7205 Gene regulation 738, Glutamine synthetase 5593 1411, 2854, 6264, 7488 8293 F-box 1501 g-catenin 7497, 7981 Gene repression 447 Glutathione 2762 F-box protein 856 g-irradiation 8521 Gene silencing 3864 Golgi apparatus 248, Fc receptors 3677 g-radiation 4969, 5897 Gene structure 5255, 7808 FDXR 7195 G1 arrest 3112, 4569 7786 gp120 3592 Fer 4997 G1 checkpoint 1571 Gene targeting 1841, gp130 460, 4778, 8186 Fertility 3644 G1 delay 140 5504, 5906 GPI motif 3089 fes 3670 G1 phase 1485 Gene therapy 708, 1208, G-protein coupled FGF 1841, 1978, 2433, G1/S cyclins 8158 4558, 5716, 6278, 6915, receptor 1658 3889, 400 G1/S transition 5665 8020 G-proteins 1171 FGF receptor 400, 3889 G2 arrest 6249 Genechip 1934 Granulocyte 3377 FGF signaling 8128 G2-M arrest 8696 Genes 2270 Grb2 1800, 2037, 5224 FGF-2 7027 G2/M transition 1233 Genetic epidemiology Growth 4435, 5127, 7514 FGF-3 1899 G2 8089 7307 Growth arrest 7897 FGF-4 899 G2 arrest 2102 Genetic instability 494, Growth control 1527 FGF8 5069 G2/M arrest 8414 1768, 2051, 2320, 7507, Growth factor FGF-binding proteins GADD45 8696 8994 dependence 2785 5733 GADD45 3391, 6222 Genetic susceptibilities Growth factor(s) 2201, FGF-BP 5733 Gadd45a 6228 6870 5175, 7464 FGFR4 8251 GADD153 2171, 4289 Genetic techniques 7164 Growth hormones 6970 FHIT expression 2398 Gain of function 4595 Genetic variants 5960 Growth inhibition 2357, (s) 1978, 4277, GAL4 transactivation Genetically engineered 5325, 7850 5765 assay 2181 mice 7453 GSE 6713 Fibronectin 8037 Galectin-3 8001 Genetics 1411, 1928, GSK-3b 2721, 4060 Fibrosarcoma 8830 Gamma interferon 4997 7164, 7412, 8192 GSTP1 1048 Fibulin-1C 1097 Ganciclovir 2141 Genome instability 532, GST pull-down 6729 Fibulin-1D 1097 Gap junctions 1989, 6657 Guanine nucleotide 7720 Fin1 6184 4992 Genome scan 3909 Guanine nucleotide FLIP 337 Gas 6 329 Genome stability 592, exchange factor 2425 FLRG 2227 Gastric cancer 2919, 7230 FLT3 2555 4080, 6113, 6549, 8351 Genomic imbalances H19 gene 1625 Fludarabine 4473 Gastrin 7656 5097 HaCaT 7092 Fluorescence in situ GATA-1 3368 Genomic instability 503, Haemopoietic 3068 hybridization 5631 GATA1 6669 890, 909, 954, 2981, Hamartin 4050 Focal adhesion kinase GCIP 3784 6241, 6614, 7235 HAT 7241 1450 G-CSF 5346 Genomic scanning 5414 HB-EGF 2584 FOG-1 3368 GDNF 1739, 5582 Genomic stability 2130, HBp17 5733 Follistatin 2227 Geminin 6624 8895 hBUB1 4673 Follistatin and antiproli- Gene amplification 825, Genotoxin exposure 1768 HBV 377 ferative 4738 5823 Germ cell tumour 8878 HBx 6606 Forkhead transcription Gene chip 8749 Germline 3988 HCC 6606 factors 1556 Gene conversion 5929 Gfi-1 1571 Hck 8075 fos 738 929, GLI 2476 HCT116 cells 4009 Fra-1 4843 1423, 2433, 2634, 2741, GLI genes 5529 HCV NS5A 4801 Fra-2 4843 2768, 3121, 3253, 3814, Glia 4050 HDAC 7241 FRA3B 8713 4403, 5380, 5814, 6366, Glioblastoma 87, 5897, HDAC1 3232 FRA6F 7266 6510, 8206 5956, 7824, 8404, 8723 HDM2 1955 Fragile sites 7266, 7671 Gene expression and Glioblastoma multiforme Head and neck cancer Frameshift (s) regulation 4879 5038 1510, 2634, 4231, 4462 3038, 5081 Gene expression profile (s) 239, 656, 921, Head and neck neoplasm FRET 356 6549 1325, 4212, 5601, 7164, 5016 Friend leukemia cells Gene expression profiling 8011, 8705 Head and neck 7933 3095 Global genomic repair squamous carcinoma(s) Friend virus 1272 Gene expression 8949 8206, 6598 Frizzled 6598 regulation 8506 Glucose 282 Heat shock 1090 Functional cloning 6936 Gene filtering 4855 Glucose deprivation 337, Heat stress 4042 Functional genomics Gene mapping 6858 6082 Hedgehog signalling 5753 Gene promoter 5069 Glut-1 282 5529 Fusion transcripts 419 Gene rearrangement Glutamate transporter HELAD1 6387 Fv2 3562 1922, 5108 GLT-1 8293 6387

Oncogene Volume 21 keyword index

9085 Helix – helix interaction Histone H2AX 8967 Hras1 5643 Hyper-recombination 5891 Histone H3 3103 H-ras mutant 5649 9008 Helix – loop – helix Histone kinase 5313 H-REV107-1 2829 Hypomethylation 5414 protein 1812 Histone methylase 5361 hSNF5 6403 Hypoxia 3532, 6017, Hematological Histone methylation 9033 hSNF5/INI1/BAF47 7671 malignancy 5758 Histone methyl 5193 Hematopoiesis 3260, trans-ferase 148 hTERT 128, 541, 611, I-kappa B (IkB) 4490 3262, 3284, 3295, 3334, Histone/protein acetyl- 650, 665, 675, 769, I-SceI meganuclease 7671 3359, 3403, 3414, 3475, 2253 3130, 3517, 7121 IkB 6510, 8759 3855, 4778 ‘Hit and run’ 825 hTERT promoter 4757, IkB-a transgene 4569 Hematopoietic cells 2641 HIV 7464 7991 IkB kinase (IKK) 4490 Hematopoietic Pbx HIV-1 transcription 5797 HTLV-1 7241 IAP(s) 260, 2283, 5763, interacting protein hiwi 3988 HTLV-1 provirus load 6809 6766 HMGA proteins 3644 2466 IB-MECA 4060 Hematopoietic stem HMGA1 2971 HTLV-I 7230 ICAM-1 5213 cell(s) 680, 3270, 3274 HMGA2 3190 hTR 650, 664 ICI-182,780 964 Hemizygous deletion hMLH1 5696 HtrA1 6684 Id-1 8498 6567 hMLH1 1443, 5758 Human 1135 Id2 8302 Hemoglobin 8361 hMre11 1633 Human brain tumors IEX-1 3706 Virus 2926 hMSH2 5696 8428 IEX-1 and transcription Virus 2926 hMSH2 5758 Human bronchial 6819 Hepatitis viruses 2593 HNF1 8251 epithelial cells 7471 IFN-a 7700 Hepatoblastoma 4863 HNPCC 7585 Human cancer cells 6498 IFN-b 7700 Hepatocellular hnRNP 580 Human carcinoma 2334 Ifosfamide 7700 carcinoma 789, 1225, hnRNP A1 8577 Human cells 7630 IGF-1 5673 1518, 1791, 2593, 2926, hnRNP K 7187 Human cervical cancer IGF-1R competence 4863, 5946, 7971, 8293 Hodgkin lymphoma 4908 6041 factor 2785 Hepatocyte 1548 Hodgkin’s disease 3095, Human chromosome 3 IGF-I receptor 8240 Hepatocyte proliferation 8173 6915 IGF-II 8240 1335 Hodgkin – Reed- Human gene therapy IGF-I receptor 1890 Hepatocyte proliferation Sternberg cells 2493 2670 IGF1 receptor 5684 and apoptosis 1539 Homeobox gene 798 Human herpesvirus 8 IGFBP-rP1/mac25 140 HER-2/neu 3532 Homologous (HHV8) 1823 IgM 8388 HER1/HER2 inhibitors recombination 1130 Human mammary IL-2 2466, 5182 119 Homologous recombina- epithelial cells 128, IL-3 2641 HER2 1159, 4289 tion 488, 954, 2873, 6328 IL-6 32, 2584, 3552, HER2/neu 890 3076, 4176, 5002, 5188, Human papillary thyroid 6791, 8404 HER2/neu 5224 8981 carcinoma 4830 IL-6/LIF 8186 HER3 8442 Homology domain 7720 Human papillomavirus Imatinib 8584 HER4 8442 Homozygous deletion (HPV) 419, 1510, Immediate early gene Heregulin(s) 78, 4289, 1217, 1461, 5631 8713 3706 4567, 4900, 8442 Hormone-resistance 7861 Human skin 2991 Immediate-early Hes 3855 HOS 856, 1501 Human T cell leukemia apoptosis 4237 Heterochromatin 512, Host cell factor 1 virus 6751 Immortality 627 553 (HCF-1) 5245 Human Immortalization 128, Heterodimer 1870 HOX gene 3659 494, 503, 598, 4200, Heterozygous state 1401 Hoxa9 4247 5946 4577, 4873, 6328, 7121 HGF transgenic 1791 HOXD3 798 Human tumors 7266 Immune evasion 7808 HGF/SF 217, 1000, 2309 Hp95 6801 Humans lens epithelial Immunity 8668 HIF-1 282, 4212 hpttg proto-oncogene cells 3784 Immunoglobulin heavy HIF1a 2455 8173 HUVEC 844 chain gene 4983 High molecular form of HPV 16 E6 7507 Hydrogen bond 7100 Immunoglobulins 1922 FGF-2 6471 HPV 165, 5665, 5877, Hydroxyurea 7226 Immunohistochemistry Histone acetyltransferase 6241, 8140 Hydroxyurea-mediated 643, 4830, 8173 2729 HPV E6 5088 DNA synthesis Immunotherapy 674 Histone deacetylase 1 HPV E6/E7 2334 inhibition 2079 Imprinting 5400 8388 HPV16 6041 Hypermethylation 2328, Inbred mouse strains Histone deacetylase(s) hRad9 7710 4231, 5450, 5696 5975 719, 5361, 6340, 6703, hRad17 7710 Hypericum perforatum Induced apoptosis 5024 7991 H-ras 5649 1242 Inducible ras 3058 Histone H1 8397 H-Ras 4448 Hyperplasia 1899 Inducible transgene 5504

Oncogene Volume 21 keyword index

9086 Infant leukaemia 4706 In vitro colony forming KLF5 6567 Loss of heterozygosity Inflammation 4266, 4728 cells 3284 KLK4 7114 1225, 2398, 2593, 2840, Inflammatory mediators In vivo gene tracking Knock-in 3445 3961, 4462, 5631 6264 3274 Knockout 347 Luca region 4521 ING family 4462 In vivo mutant rates 7235 K-ras 8732 Luminal epithelial 6573 ING3 4462 Ionising radiation 1108 K-Ras 3792 Lung 5814, 7749, 7831 Inhibition of Bcr-Abl Ionizing irradiation 4873 K-RAS 4301 Lung adenocarcinoma 8560 Ionizing radiation 2334, K-selection 3043 3804 Inhibitor of apoptosis 4191, 6317, 6377, 6633 532, 6377 Lung cancer 65, 2328, protein 5024 Ionizing radiations 2320 Ku complex 512 2398, 2418, 2822, 3003, Inhibitor(s) 6413, 8541 IRFg 2829 Ku proteins 5725 4129, 4521, 4577, 4822, INI1 6403 IRF-1 2829, 3391, 7776 5450, 5804, 6868, 6884, INI1/SNF5 3112 IRF5 2914 L6 myoblasts 7027 6908, 6915, 6960, 6970, Initiation 7392 IRS-1 5684 lacI 7126 7284, 7298, 7365, 7421, INK4a/ARF 1518, 3207, Isoforms 8240 Lactogenesis 4900 7435, 7497, 7598, 8347, 4498 ITM2Bs 3181 Laminar flow 1450 8683 iNOS 8047 Laminin receptor 7478 Lung cancer cells 798 Inositol hexakis- J-774 cells 3677 Large T antigen 5725 Lung carcinoma 2171 kinase JAB1 3003 Laser capture micro- Lung neoplasms 6949, 1882 JAB1/CSN-5 3507 dissection 4587 7341 INrf2 6829 Jak 5346 Latent membrane Lung tumor progression Insertional mutagenesis JAK kinases 3334 protein-1 1263 gene 5814 419, 7247 JAK-STAT 4812 LATS1 1233 Lung tumor(s) 2750, In situ hybridization Jak-Stat signal Lck 7205 6382, 6858, 8732 4830, 7545 transduction 8404 Leader protein 5574 LY294002 1263 Insulin 7131, 8240 Jak2 tyrosine kinase 7137 LEF/TCF 6983 Lymphomagenesis 299 Insulin growth factor-1 JAM 7642 Lesion bypass poly- Lymphoma(s) 680, 3314, receptor 2785 JB6 cells 2181 merases 8957 3898, 4673, 4978, 5108, Insuling signaling 3739 JCU 5574 Leucine zipper 3879 5182, 5280, 6559 Int2/Fgf3 5548 JNK(s) 849, 1017, Leukaemia 4247 Lymphovascular invasion Integration 419 15802387, 2441, 2573, Leukaemias and 3631 affinity 3939, 5038, 5335, 5923, lymphomas 3445 Lyn 5346 modulation 4448 7533, 8047 Leukemia 680, 1611, LYVE-1 7945 Integrin(s) 96, 2513, JSAP1 6488 2555, 3247, 3314, 3422, 3889, 3969, 8605 Jun 738, 3391 4673, 5160, 7247, 8262, 3670, Inter-specific consomic JunB 7156 8536 7175 (ICS) 6680 JunD 6434 Leukemic cells 3213 Mad 5557 Interferon 1251, 1882, Jurkat 3213, 5108 Leukemogenesis 3260, Mad1ER 447 2295, 7957, 8741 Juxtamembrane 2555 3414, 8577 MAGE genes 5400 Interferon regulatory Juxtatropic membrane Li-Fraumeni 2961 MAGI 5088 factors 6751 TNF like action 4257 Li – Fraumeni syndrome MAGI-1 8140 Interleukin-2/15 receptor 8949 MAGUK 5088 2009 K252a 4885 Ligation mediated PCR Malignancies 3475 Interleukin-21 receptor Kaposi’s sarcoma 5743 Malignancy 3459 gene 368 associated herpes virus Light chain 3 7060 Malignant rhabdoid Interleukin-6 1346, 1391 (KSHV) 1823 LINE-1 5400, 5593 tumour 6403 Internal tandem KDR 6307 Linkage analysis 8356 Malignant solid tumors duplication 2555 Keratinocyte Linkage disequilibrium 1679 Intestinal epithelial cells differentiation 738 6858 Malignant 2908 Keratinocyte(s) 947, Liposome 2662 transformation 2484 Intronic enhancer 8251 1616, 2652, 2991, 4728, Liver 32, 377 MAM domain 3089 Intronic response element 5135 Liver mass homeostasis Mammalian cell extracts 3050 Kidney 5582 1335 5204 Invasion 87, 798, 1812, Kidney development Liver 6689 Mammalian cells 6356 4080, 4549, 5601, 6049, 2948 Liver regeneration 1548 Mammalian 6740, 8705 Kinase activity 4191 LMP1 4166, 8047 embryo-genesis 2880 Invasive ductal Kinases 96, 6413, 6175, Lobular carcinoma 3241 Mammalian gene carcinoma 3241 7464, 7630 Lobuloalveoli 4900 amplification 7671 Invasiveness 2365, 7824, Kirsten-Ras (Ki-Ras) LOH 158, 1518, 2919, Mammalian RAD51 8178 4490 5975, 7580, 8356 4065 Inverse PCR 4983 KIT 4351 Long-patch BER 5912 Mammary 1009, 6446

Oncogene Volume 21 keyword index

9087 Mammary adeno- Medulloblastoma 1461, Microarray 798, 1359, MnSOD 3603, 3836, carcinomas 5643 7580 1934, 2880, 3814, 5504, 3917, 4392 Mammary cancer 4335 MEF 6713 6549, 7256, 7598, 7749, Molecular detection 7289 Mammary carcinogenesis Megakaryocyte 3359 8196, 8361 Molecular epidemiology 2797 Megakaryopoiesis 6669 Microarray analysis 7376 Mammary carcinomas 6201 8206 Molecular marker 6960 1785 Meis1 4247 Microarrays 2009 Molecular mechanisms Mammary epithelial cells MEK kinase 6791 Micrococcal 8547, 8605 4289, 4747 MEKK1 4384, 5923 1649 Molecular pathogenesis Mammary gland 198, MEKK3 8089 Microenvironment 3262 6868, 8652 291, 6366 MEKs 2236 Microsatellite instability 3377 Mammary gland Melanocortin 1 receptor 2873, 3253, 4894, 5081, Monosomy 7 4849 development 4900, 8037 5696, 5758, 6299, 7289, MORF 2729 7214 1000, 1668, 7585 Morphogenesis 2309 MAP kinase 3011, 3038, 3969, 6684, Microtubule organization Morphology 5313 849 7001, 8037, 8741 center 6195 Mos 6425 MAP kinase(s) 849, 1171, Melanoma differentiation Microtubules 5619, 6766 Motility 4435, 8272 2805, 4071, 4921, 5038, associated gene-7 708 Migration 4080, 4765, Mouse 4696, 5814, 6858 6356, 6540, 7839 Membrane potential 8149 7656 Mouse brain tumor MAPKAPK-2 1580 MEN 2 479 mIMCD3 5583 models 7453 MAPK(s) 1017, 2513, Menin 6434 Mini- 5649 Mouse knockout cells 3670, 4000, 4323, Meningioma 239 Minimal residual disease 2484 4567, 6413, 6434, Merlin 5990 7817 Mouse lung tumors 5960 6649, 8498 Mesangial cell 1750 Mismatch recognition Mouse model(s) 584, Marked box 8388 Mesenchyme 2029 1909 2840, 4335, 5097, 5504, Maspin/PAI-1 chimera Mesothelial cell 4340 Mismatch repair 2840, 8612, 8629 4089 Mesothelioma 1141, 2873, 5934, 6299 Mouse nerve sheath Mass spectrometry 4403, 1434, 2896, 4340 Mismatch repair gene tumor models 7453 8029 Met 217, 4885 mutation 7585 Mouse skin cells 3949 Mathematical computing Metal-dependent Mispairing 2130 Mouse thymic 7164 cleavage 9022 Mitochondria 377, 1251, lymphomas 6680 Mathematical modeling Metalloproteinases 1963, 3139, 3149, 4009, MOZ 2729 7164 2089 4149, 4323, 4944, 6458, MPF 1717 Matrix metalloproteinase Metaplasia 4099 7839, 8149, 8675, 8786 MPS1 kinase 6161 1187, 3949, 4728 Metastasis 1800, 1812, Mitochondrial DNA Mre11 8967 Max 8515 2245, 2504, 2822, 3541, 3780 mRNA 3095 MBP-1 2775 3631, 4129, 4932, 5127 Mitochondrial membrane mRNA processing 5619 MCF-7 breast cancer Methotrexate 8361 permeabilization 1242 Msh6 7126 cells 2212 Methyl binding proteins Mitogen-activated MSI tumors 8062 MCF7 4626 2704 protein kinases 1539 MSP 2418 MCF-7 cells 2365, 4323 Methyl-CpG binding Mitosis 437, 5619, 6154, MT1 – MMP 5861 MCF10A 1590 protein(s) 4822, 5394 6184, 6201, 6249 MT-MMP 8011 M checkpoint 1717 Methylated DNA Mitosis checkpoint 4673 MTG16 6703 Mcl-1 1359, 1563 binding domain Mitotic kinases 8282 mTOR 5325 MCSF 3670 column MKP-1 4435 MUC1 3631 MDA-7 4558 chromatography 3804 Mlh1 9033 Muc4 7524 MDCK cells 1658 Methylation 1217, 1443, mLin-7 2545 Multidrug resistance MDM2 2476 2418, 3020, 3792, 4340, MLL 4706 2365, 5160 mdm2 2961, 4715, 8223 5450, 6835, 7034, 7277, MLN51 4422 Multiple mutations 1768 Mdm2 1208, 1299, 2413, 7289, 7897, 8351, 8372 MluI cell-cycle box Multiple myeloma 1346, 2750, 4414, 7100, 8776 Methylation spreading (MCB) 7786 1391, 5673, 6587 MDM2 2376, 2605, 4220, 5388 MMAC 2357 Multistep tumorigenesis 4498 Methylation tolerance MMC 5002 3043 MDMX 867 2873 MMP 2245, 4549 MuLv 6559 MdmX 8776 Methylnitrosourea 8732 MMP2 5765 Muscarinic receptor 2762 MDR (multidrug MGMT 5940 MMP-9 272, 5213, 5601, Muscle differentiation resistance) 1295 MGMT 8878 8011 4137 MDR 1945 Mgmt 9033 MMP inhibitors 2245 Mutagenesis 2320, 4065, MDS1 3232 MHC class I 248, 7808 MMPs 8128 8166, 8895 Medullary thyroid MIC-1 4212 MMTV/v-Ha-ras mice Mutagens and carcinoma 2376 Mice 291 8486 carcinogens 8957

Oncogene Volume 21 keyword index

9088 Mutant p53 4595 Neuronal stem cells 5255 NTRK1, oncogenic Origin of mutations 8957 Mutation detection 1909 Neuropathogenesis 3592 activation 8334 Ornithine amino- Mutation frequency 2873 Neuropathological Nuclear accumulation transferase 8293 Mutational hotspots evaluation 7453 5002 Ornithine decarboxylase 5704, 6898 Neuropilin-1 427 Nuclear export 6766 3620 Mutational spectrum NF1 4978 Nuclear F-actin 356 Osmotic shock 947 6898 Nf2 5990 Nuclear factor-kappa B Osteoblast 7156 Mutation(s) 1167, 1225, NF-kappaB 4392 (NF-kB) 3727, 4490 Osteonectin 7077 1641, 2593, 2919, 3780, NF-kB 260, 1062, 1759, Nuclear import 6766 Osteosarcoma 5975 4307, 4702, 4863, 4992, 2066, 2484, 2493, 3603, Nuclear localization 3003 Ovarian 4435 5016, 5906, 5956, 7289, 3898, 3917, 4601, 4969, Nuclear receptors 2854 Ovarian cancer 1097 7605, 7971 5763, 5797, 6510, 6819, Nuclear signaling 8453 Ovarian cancer cells 1 Mutator phenotype 7235 8759, 8852 Nuclear staining 2679 Ovarian cancer Myb 400 NF-Y 8862 Nuclease 9022 chromosome 6q27 387 MYC 7235 NGF 22 Nucleolar localization Ovarian epithelial cells myc 165 NHEJ 6471 2447 6289 Myc 447, 1922, 3827, Niche 3262, 5441 Nucleolus 4498, 6703 Overexpression 239, 4838, 5835, 6498, 7765, Nicotine 7412 Nucleotide damage 1649 3532, 4830, 5056 8515 Nicotine dependence Nucleotide excision- Oxidative damage 5204, MYC 8510 7349 repair 8949 7533, 8675 MYCN 1848 Nijmegen breakage Nucleus 4691 Oxidative DNA damage MyD88 3391 syndrome 8967 Nucleus, endoplasmic 3571, 8905 MyD118 3391 NIMA 6184 reticulum 1123 2762, Myeloid 1600 Nitric oxide 8047 Null mutant 3225 3872, 4363 Myeloid differentiation NK-kB 856, 1501, 3213 NUP98 3422 Oxidized guanine base 3475 NLS 4422 Nup98-HoxA9 4247 8895 Myeloid leukemia 4849 nm23-H1 2097 Nur77 3925 Oxidoreduction potential Myeloma 2584, 5289, nm23-H2 2097 Nutrition 3663 2406 6848, 8769 N-methyl-N-nitrosourea Oxygen free radicals 8905 MYND domain 5245 2797 O6-methylguanine 8886 Oxygen radicals 8895 Myoblast 5268 NMR 2119 ODC 4328 Oxytocin receptor 1658 MyoD 4137, 8114 N-myc 2097, 3552 Oesophageal cancer 6395 Myogenesis 2901 N-myc 3879 Oestrogen receptor 5773 P protein 7957 Myogenic differentiation N-Myc 4549 OGG1 8232 p0071 7042 4838 Non homologous end Okadaic acid 3103 p107 4635, 7891 II regulatory joining 2525, 5654 Oligodendroglioma 3961 p107 pocket protein 7923 light chain 5852 Non-small cell lung Oligomerization 176, p120ctn 7067 MYST 2729 cancer 6936, 6877 2130 p130 7569 Non-coding RNA 1625 Oligomycin 8149 P13K-AKT 307, 697 Nasal NK/T cell Non-coding transcripts Oligonucleotide arrays p14Arf 6779 lymphoma 4702 3029 6289 p14ARF 2750, 3149, 4220, NATH 5056 Non-immunoglobulin Oligonucleotide 6898, 8372 Nbk 227 gene 368 microarray 3961 p15INK4B 8372 NBs 4191 Nonmuscle cells 5852 Oligonucleotides 631, 638 p16 2108 NBS1 8967 Nonseminoma 3909 Oncogene cooperation p16INF4a 4231 NCI drug screen 119 Nore1 1381, 2713 1335, 8629 p16INK4a 1876, 5960, N-CoR/mSin3A core- Normal cells 688 Oncogene 6328, 8372, 2652 pressor complexes 5245 Northern hybridization 1272 p16INK4 6908 Necrosis 6091 3592 Oncogene transformation p16INK4a 1823 Nectin 2545, 4108, 7642 Notch 3262, 3855 347 p16ink4a 5193 Nek2 6184 Novel gene 3029, 3089 Oncogene(s) 119, 697, p19ARF 4978 Neo-vascularization 1309 NPM-ALK signaling 937, 1150, 1611, 1625, p19ARF 3827 Neoplasia 4099 1038 2066, 2864, 2939, 3058, p21 1285, 2102, 3207, Neoplasm 1295 NQO1 2191, 5301 3796, 4200, 5108, 7421, 3611, 4414, 5912, 6234, Neu 291 Nrf2 2191, 6829 7593, 8506 7100, 7226, 8114 Neuregulin(s) 4900, 8442 NRK 1777 Oncogenesis 4978 p21-activated kinase 3939 Neuroblastoma 1848, NSAIDs 6032, 8347 Oncogenic p218 1285 2097, 3552, 4549, 5823, NSCLC 7497 transformation 6983 p21waf1 5773 5967, 6132, 8356 N-terminal domain Oncostatin M 460 p21CIP1 1590, 8067, 8089 Neuroendocrine 6908 6722 Oral cancer 4231 p21Cip1 8486 Neuronal cells 6123 Nth 1 gene 1649 Oral cavity cancer 6480 P21Waf1/Cip1 7745

Oncogene Volume 21 keyword index

9089 p21WAF1 1571 PAI-1/maspin chimera Philadelphia Plasma cell 6848 p26Kip1 6908 4089 chromosome 8612, Plasminogen activator P27 1739, 7765 PAKs 2236 8643, 8652 8830 p27Kip1 3003, 3199, 4567, PALA 7230 Philadelphia Platelet-derived growth 6587, 7214, 8067, 8486, Pancreas 4696 chromosome leukemia factor 1870 7524 Pancreatic 7137 PLCe 8105 p300 1556, 2253, 2455 adenocarcinoma 2114, Phorbol esters 4957 Pleckstrin homology p33ING1 1208 4587 Phosphatase(s) 2387, domain 6520 p38 849, 974, 1000, 7092, Pancreatic cancer 4149, 4435, 7464 Plk3 6633 7156, 7533, 8089 4301, 5923, 6059, 7883, Phosphatidylinositol Pluripotent 8320 p38 MAPK 1978, 4601, 8251 3-kinase 5515, 6587 PLZF 6669 4567 Pancreatic intraepithelial Phosphatidylinositol PML 3422, 3925, 5557, p42MAPK 6425 neoplasia 4301 phosphatase 2357 5574, 7957 p51 2455 Papilloma 4266 Phospho-specific PMS2 2840 p53 3082, 6299 Papillomavirus 248, 947, antibodies 2236 PNT2 4328 p53 1, 9, 153, 165, 176, 1695, 7808 Phosphoinositide Point mutation 5891 356, 488, 532, 592, 731, PAPIN 7042 3-kinase 6520 Polo 6195 748, 761, 867, 878, 974, Paracrine 108 A2 5765 Polo-like kinase(s) 3162, 981, 990, 1090, 1187, PARP 5877 6520 6195, 8282 1208, 1285, 1299, 1304, PARP cell survival 3130 Phospholipase Cg2 8521 Poly(ADP-ribose) poly- 1316, 1325, 1510, 1580, PARP-1 1108 3651 merase 2890 1633, 1641, 1685, 1922, Patched 3507 Phosphoramidates 638 Polycom-group gene 299 1955, 2020, 2102, 2334, Patched-knockout mice Phosphorothioate- Polycystic 2534, 2605, 2613, 2914, 7580 modified DNA-binding 5583 2939, 2961, 2991, 3043, Pathologic mechanism sites 5117 Polymerase-b 731 3050, 3130, 3149, 3207, 7365 Phosphorylation 1090, Polymorphism(s) 769, 3525, 3784, 3796, 3827, PAX2 1009 1580, 1955, 2079, 3754, 4176, 6870, 8192 3836, 3872, 4212, 4220, 96 3969, 3978, 4137, 4158, Polypeptide chain 4277, 4414, 4498, 4613, PBP 861 4921, 6791, 7100, 8282 initiation 5325 4646, 4715, 4801, 4894, PC12 cells 6772 Phosphorylation Polyploidy 2981 5325, 5540, 5935, 6123, PCAT 2253 regulation 5031 Post-transcriptional 6222, 6234, 6249, 6366, PCNA 1717, 7710 Phosphoserine Bcr 8560 regulation 7545 6614, 6633, 6722, 6819, PCR 7289 Phosphotyrosine 1079 Postoperative recurrence 7050, 7100, 7195, 7226, PCR-based cDNA Photoreceptor cells 4635 789 7435, 7478, 7488, 7569, subtraction 2270 Photosensory pigment PPAR-g 2171 7776, 7831, 7901, 7971, PD180970 8804 9043 pRb 1510, 4158 8521, 8696, 8949 PDCD2 protein 5245 PI 3-kinase 2721 pRB 5557 p53 binding sequence Pdcd4 3076 PI 3-kinase signaling pRb pathway 4680 7569 PDGF-C 3847 7891 pRb2/p130 5897 p53-dependent apoptosis PDK-1 1727, 7891 PI-3k 5868 Pre B-cell 3076 861 PDZ 5088, 7042, 8140 PI3 kinase 1945 Prenatal developments p53 expression 5704 Pediatric tumor 4345 PI3’-Kinase 4020 2704 p53 gene 5704 pEg3 7630 PI3-K 1062 Preneoplasia 6366, 6915, p53 isoforms 6722 Peptide aptamer 5753 PI3-kinase 4508, 7027 7298 p53-mediated DNA Peptide growth factor PI3K 207, 937, 3334, Preneoplastic lesions damage response 1108 7680 4567, 5148 2398 p53 mutation 6689, 8372 Peptidyl-prolyl PI3k 7131 Prevention 5462, 7349 p53 responsive element 2261 Pigment 1841 Primary 1135 1641 Periostin 6289 Pilar tumor 5548 Primary effusion p53-responsive gene 6017 Permeability transition Pilocytic astrocytoma lymphoma (PEL) 1823 p53 target 1469 8149 5956 Proapaptotic genes 4009 p53/Trp53/TP53 190 PGP9.5/UCH-L1 Pit-1 3190 Profileration 1978 p537/7 6228 3003 Pituitary adenomas 3190 Progesterone 1009 p63 981, 2455, 7195, 8223 Ph positive leukemias Pituitary tumours 1217 Prognosis 643, 5566 p70 S6 kinase 4032, 6587 8652 piwi 3988 Programmed cell death p73 974, 1304, 3050, Phage-displayed peptide PKA 778, 4020, 7872 1242, 3459 3796, 4715, 5897, 6898, library 2662 PKB 1263 Progression 5441 7195, 8223 Phenotype of leukemia PKC 1727, 1978, 7619 Prohibitin 4539, 8388 p73L 2455 8652 PKCd 1071 Prolactin 5047 p8 1685 Pheochromocytoma 479, PKC-delta 7533 Prolactin antagonist Paclitaxel 6249 1117 PKR 6278, 8379, 8741 5047

Oncogene Volume 21 keyword index

9090 Proliferation 1686, 1812, Protein tyrosine kinase(s) Ral – GDS 937 Rel 2484, 8759 3525, 3579, 3670, 4680, 3314, 7797 RALT 6530 Rel-Nrg 8759 5148, 5835, 5951, 8037, Protein tyrosine Rap 1 778, 8105 RelA 2484 8605, 8817 phosphatase 7067 RARa 3422 Renal cell carcinoma 929, Proline-rich motif 4932 Protein – tyrosine kinase Ras 22, 53, 1381, 1527, 3507 Proline-rich domain(s) 9, 1079 2309, 2425, 3334, 3579, Reorganization of actin 2037 Proteolytic degradation 3827, 5753, 5998, 6425, filaments 5852 Promoter 921, 4663, 867 7027, 7545, 8105, 8769 Repair 3571, 6614 4715, 7478, 7786 Proteomic(s) 1625, 4403, ras 937 Repetititve sequence 789 Promoter analysis 3696 8029 RASSF1 2713 Replication blockade Promoter luciferase assay Prothymosin a 5233 RASSF1A 3792, 6835 7226 1469 Protocadherins 7861 Ras association domain Replication inhibition Promoter methylation Prox1 7945 2713 488, 3715 7585 PRP 2662 Ras effectors 937 Replication licensing Promotion 7392 PRSS11 6684 ras genes 2797 6624 Promyelocytic leukaemia Psoriasis 2991 Ras mutants 5148 Replication-associated nuclear bodies 1633 ptch 4894 ras oncogene 8397 homologous Prophase 2328 PTCH1 tumour ras oncogene 4577 recombination 4788 Prostase 7114 suppressor gene 6007 Ras pathways 6530 Replicative senescence Prostate 1135, 1899, PTEN 53, 319, 1450, Ras-transformed C2C12 4403, 981 4099, 8453 2357, 5289 cells 3739 Reporter gene assay 4983 140, 153. PTHrP 4020 Ras-ERK 697 Repression 176, 541, 1017, 1048, 1759, 2089, PU.1 3368, 3377 RASSF1 1381 2613, 5540 2679, 3082, 3727, 4328, PU.1 transcription 1272 RASSF1A 4231, 4340, Reprogramming 4739, 5069, 5609, 6835, Pulmonary adenoma 7277 leukemic cells 3284 7114, 7861, 8498, 8749 progression 1 5960 Rb 1196, 1571, 3784, Resistance 2295 Prostate cancer cells 5733 Purvalanol 6413 4539, 4635, 4691, 5193, Restriction landmark Prostate specific antigen Pyrimidine dimers 9043 8001, 8372, 8388, 8852 genomic scanning 789 153 Pyrrolo-pyrimidine RB1 (retinoblastoma 1) RET 479 Prostate tumorigenesis inhibitor 8075 1295 RET 1739, 5582 5733 RB1CC1 (RB1-inducibile RET/PTC1 8166 Prostatic acid qmyoD 4838 coiled-coil 1) 1295 Retina 1171 phosphatase 3696 Quantative PCR 2270 RB18A 861 Retinal pigment Proteases 5213 Quantitative PCR 7593 RC-K8 8759 epithelium 6101 Proteasome 3754, 5280, Quantitative real time Reactive oxygen species Retinoblastoma (Rb) 5940, 6530, 6829 PCR 6480 4392, 5844, 5886 1325, 1823, 4635, 4691, Proteasome inhibitor 165 Quantitative real-time Real time RT – PCR 6908, 8114 Proteinase-3 5160 RT – PCR 8506 4171 Retinoblastoma protein Protein domains 2253 Quantitative trait Real-time PCR 3814 761, 4481 Protein-DNA complex 5960 reaper 6458 Retinoic acid 2181, 2880, formation 2130 Quiescence 3403 Rearrangement(s) 483, 8852 Protein-DNA interaction 6841 Retinoic acid receptor 9022 Rabies virus 7957 Receptor 3562 7850 Protein expression 7114 1945 Receptor tyrosine kinase Retinoic acid receptor-b Protein kinase 6184 Rac 2425, 2641 1800, 1870, 2058, 2555, 411 Protein kinase C 3620, Rac1 7060 6382 Retinoids 411, 1539, 6113, 6348 RACK1 7619 Receptors 460 3496, 7850 Protein kinase CK2 3754, Rad50 4788 RECK 8347 Retrotransposon 5593 5031, 5280 Rad51 488, 1130, 4176, Recombinant congenic Retroviral insertional Protein kinase D 2154 4788, 5188, 8981 (IRCS) strains 6680 activation 1150 3103 Rad51 foci 5002 Recombinase 5504 Retroviral vectors 3274 Protein – protein Radiation 1882, 2376, Recombination 522, 598, 8262, 8643 interaction 7187 2398, 4032, 7100 4065, 6614 Retrovirus vector 2670 Protein stability 4384 Radiation damage 8926 RecQ 954 Reverse Northern Protein structure 2253 Radio-sensitization 7883 RecQ helicase 9008 hybridization 3592 Protein synthesis 5325 Radioresistance 5998, Redox 282, 6317 Reversible Protein-truncating 6471, 8683 Redox regulation 2191 transformation 3058 mutation 6689 Radon 7365 Reduced expression 4462 rgr 5108 Protein turnover 7776 Raf 937, 3651, 5268 Regulation 541, 688, 964 Rhabdoid 5193 Protein tyrosine Raf-1 6328 Regulatory Rhabdomyosarcoma phosphatase 2573 Ral 7557 phosphorylation 2236 2901, 3029

Oncogene Volume 21 keyword index

9091 Rheb 6356 Seminoma 3909, 3988 Small cell lung carcinoma Src kinases 3334 Rho 1590, 2425 Senescence 532, 627, (SCLC) 3814, 6877 Src/Yes 4879 Rho 2901, 4020 2447, 2991, 3270, 4277, Small intestinal S. stercoralis antigen Rho proteins 2236 5135, 5557, 6328, 7266, epithelium 7126 2466 Rho-kinase 5852 7897 Small intestine 158 Stability 2119 RhoA 8470 SEPTIN6 4706 smgGDS 2425 Stable transfectants 5601 RhoB 5998 Serine protease 6684 Smoh 6007 Stat1 2504 RhoG 207 Serine theronine kinases Smoking 2398, 7289, Stat1 2504, 4473 RhoGEF 4601 6649 7298, 7365, 7412 Stat3 217, 1038, 3082, Ribonucleoprotein 564 Serine15 1090 Smoking cessation 7349 3552, 3949, 4997, 6791, ribonucleotide reductase Serpin 4089 SN-38 3611 7001, 7611, 8186, 8404 R2 909 Serum 6960 Snail 3241 Stat3 activation 2000 Riboregulator 1625 SH2 4422 Socioeconomic level 7341 Stat3b 217 Ribozyme-targeting 5733 SH3 2037, 4422 SOCS 4812 Stat5 1668, 2846, 8577, RING finger 7957 Shc 1800, 3872, 6307 SOCS-1 4351 8075, 8804 Ring Finger domain 5024 Shc family 22 Soluble Eph receptor Stat5a 4335 RING-H2 finger 3507 Shc family proteins 7011 STAT(s) 3334, 3579, Risk assessment 7376 5823 Somatic cell 564 5346 RIZ 3038 Shear stress 1450 Somatic cell hybrids 8536 Staurosporine 65, 4089 RLGS 3909, 5414 SHH 6007 Somatic hypermutation Ste20 3939 RNA 564 ShIF 844 483 Stem cell factor 1556 RNA interference 5716, SHIP 5289 Somatic mutation 2840 Stem cell(s) 3284, 3988, 6041 SHIP-1 1477 Sonic hedgehog 2670, 4778, 5441, 8310, 8320 RNA polymerase I 2447 Short mononucleotide 8196 Steroid hormones 5175 RNA polymerase III repeats 8062 Sorbitol 2441 STI571 5716, 5868, 8541 2961, 5540 SHP-2 1870 SOS response 8949 Stk 3562 ROS 7195 Sialyl-Lewis X/A 3631 Sos1 7060 Stratifin 8310 Rothmund-Thomson Signal tranduction 53, SOX9 7850 Stress kinase(s) 2573, syndrome 9008 119, 611, 1123, 1423, SP-C 7831 4384 RPE 1841 2201, 2641, 3314, 3359, Sp1 738, 7786 Stress response 6017 R-Ras 4448, 7557 3562, 4508, 5175, 5289, SPARC 7077 Stroma 2029, 8830 RRE 7187 6101, 6264, 6649, 7464, Specificity 1563 Structure-function 4448 rRNA transcription 7619, 7690, 8568, 8871 Spectral karyotyping Structure-function 2447 Signaling 400, 6348, (SKY) 890, 4706 relationships 9022 r-selection 3043 7524, 4812, 8629 Spectrin 5255 Suberoylanilide RT – PCR 2704, 4830, Silencing 3792, 5358, Spermatogenesis 899, hydroxamic acid 427 4983, 5804, 6289 5380, 5388 3644, 3988 Substrate specificity 3103, Runx1 2729, 8428 Silibinin 1759 Spheroids 307 7205 RUNX1 3247 Single cell-based analysis Spindle assembly Subtractive hybridization Runx2 2729, 7156 7545 checkpoint 6161 3814, 7598 Runx3 8351 Single nucleotide Spindle pole body (SPB) Suicide gene therapy polymorphism 7745 6161, 6195 2141 S phase checkpoint 3715, Single-strand annealing Splice mutation 4171 SUMO 7957 6377 5188 Splicing 5649 SUMO-1 7913 SAGE (Serial Analysis of Sir proteins 512 Sputum 6960 Survival 1263, 3213, Gene Expression) 836 Skin 1527, 3765, 4728 Squamous cancer 5135 6498, 8817 SAGE 929, 6366 Skin cancer 3836, 4894, Squamous carcinoma Survival signals 3651 Sam68 2037, 7187, 7205 4969 3688 Survivin 2613 Sarcoma 2261, 4978 Skin carcinogenesis 53, Squamous carcinoma Susceptibility 6858 Satellite DNA 5400 1501, 3620 subtypes 8206 SV40 190, 1141, 1434, Saturation density 3058 Skp2 6587 Squamous cell carcinoma 2896, 4328, 4340 Schizophrenia 7266 SKY 5097 1187, 2670 SV40 chromosomes 5929 Sck 6307 Sm proteins 5619 Squamous cell carcinoma SV40-TAg 128 SDHD 7605 Smad 2227, 5783, 8776 of the head and neck SV40 T antigen 981, 4335 Second messenger 44 Smad3 5660 2846 SWI/SNF 5193 Segregation of partly Smad 4 158, 1616, 4696, Src 1695, 2037, 4020, SWI/SNF 6403 melted molecules 6049 4508, 6340, 6488, 6992, SWI/SNF complex 3804 Smad7 4879 7001, 7256, 7619, 7797, 3112 Selenium 3663 Smad signaling 4879 8075, 8723 Synovial sarcoma 4181, Self-renewal 4778, 2864 Small cell lung cancer Src family kinases 1707, 5791 III 427 8310 3677 Syntenin 4080

Oncogene Volume 21 keyword index

9092 Synteny relationship Testicular cancer 8878 Tobacco use 7326 Transforming activity 5975 Testis 899, 3644 Tolerance 6082 4374 Synthetic inhibitor 2089 Tetracycline-inducible Topoisomerase I 6614, Transforming growth SYT-SSX 4181, 5791 system 3445 7913 factor beta 8272 TFIIH 4921 TPA 1071, 6657 Transgene 6559, 8166 t(16;21)-positive myeloid TFIIIB 5540 TPE 512 Transgenic 198, 899, malignancies 6703 TFPI-2 921 T-PLL 483 1841 t(2;5) 1038 TGB-b 108, 3422 Tpo receptor 6669 Transgenic mice 738, t(3;16)(q27;p11) TGFb 798, 2227, 4879, TRAF proteins 2493 1028, 1548, 1899, 3190, trans-location 368 5783, 6049, 7147, 7839, TRAIL 260, 337, 1135, 3445, 3620, 5182, 6382, t(3;21) 3232 8776 2283, 2623, 3139, 4323, 7214, 7831, 8732 TACC proteins 5619 TGF-b1 1616, 7156 4558, 5763, 8510 Transgenic mouse 6657 TAFII31 7100 TGF-b signaling 7883 TRAIL/Apo2L 6032 Transgenic rats 2797 Tag 2896 TGF-b type II receptor Transactivation 6606, Transgenic shuttle-phage T-ALL 483 (TGF-bRII) 7883 7226 7126 836, 964, TGFb type III receptor Transcript map 6395 Translation 7891 2815, 3517, 3603, 4626 3541 Transcription 153, 541, Translocation 1890, Target gene(s) 2829, Thapsigargin 2623 990, 1411, 1812, 2613, 3314, 4374 2914, 4663, 6983, 7077 The patched gene 2670 2961, 3422, 3898, 4843, Transplantation 3270 Target identification 7749 Therapeutic response 5540, 5660, 5783, 6340, Transrepression 2181 Targeted therapy 6970 8769 6751, 7933, 8862 TRAP 665 Tax 7241 Therapy 7593, 8262 Sp1 TRAP220 861 Tax gene amplification Thermostable ligase 1909 1485 TRC8 3507 7230 Thiazolidinediones 2171 Transcription factor(s) Treatment(s) 7412, 8547 t-BHQ 5301 Thioredoxin 1625, 2406, 1859, 3295, 3368, 3949, Trefoil factors 4020 T-box 3827 6317 4908 TRF2 532 Tbx3 3827 Thioredoxin reductase Transcription initiation Trichostatin A 427, TC21 1062 6317 7786 6340 T-cell activation 1571 Thrombopoietin 3359 Transcription regulation Trigger 5380 T cell factor 2679 Thymidine kinase 8340 8477 Tristetraprolin 4237 T-cell lymphoma 8173 Thymidine Transcription-coupled Trithorax genes 4849 T cell(s) 7205, 8668 phosphorylase 8477 nucleotide excision Trk 22 Tcf 8340 Thymocyte repair 5743 Trp53 5643 Tcf-1 6446 differentiation 299 Transcription-coupled Trp53 4635 TCF/LEF 8453 Thymus 3765 repair 8949 TRRAP 5835 TCF/LEF-dependent Thyroid 778 Transcriptional TSC2 8470 transcription 5906 Thyroid carcinoma 5056 activation 176, 1611, TSP-1 7945 TCr 2029 Thyroid cell 2971 5877, 7872 TSG101 4830 Tel-Jak 4351 Thyroid hormone 761, Transcriptional factor TSLC1 6936 Telomerase(s) 494, 503, 4307 4983 TSLL1 6936 512, 522, 541, 553, 564, Thyroid receptor genes Transcriptional TSLL2 6936 580, 584, 592, 611, 619, 4307 co-repressor 6703 Tuberin 4050, 8470 627, 631, 643, 650, 656, Thyroid tumor 8166 Transcriptional Tuberous sclerosis 664, 674, 680, 688, TIEG 5783 regulation 921, 1309, complex 8470 1434, 3011, 3130, 3517, Tight junctions 7642 3199, 3925, 7478, Tumor angiogenesis 3784, 4071, 4200, 7121, TIMP 2245 7730 2000, 7011 7740, 7897, 8020, 8262 TIP49 5835 Transcriptional Tumor antigen 239 Telomerase activity 447 Tissue arrays 4587 repression 3496, 5361, Tumour-associated 3879 Telomerase inhibitors Tissue microarray 2476 5394, 5557 Tumor associated antigen 638 Tissue specific 738 Transcriptional 674, 5006 Telomerase reverse Tissue-specific expression suppression 3706 Tumor associated transcriptase (hTERT) 3696 Transdifferentiation 5548 proteases 4257 643, 656 TMA 2476 Transferrin receptor 7933 Tumor auto-immunity Telomerase RNA 656 TNFa 929, 2441, 3917, Transformation 697, 5006 Telomere capping 553 4237, 4384, 5024 1062, 1611, 1695, 1707, Tumor cell survival 7001 Telomere(s) 494, 512, TNFR2 signaling 4257 1800, 2901, 2971, 4200, Tumor cells 2347 532, 553, 580, 584, 592, Tobacco 7284, 7307, 7376 4448, 4577, 5990, 6540, Tumor control 3603 598, 627, 680, 611, 619, Tobacco control 7349 7121, 8568 Tumor emboli 3631 825, 3270, 6884, 8262 Tobacco smoke 6898 Transformation response Tumor growth 447, 2504, Terminal exon 5649 Tobacco smoke pollution 3949 3541, 8128 TERT 4071 7341 Transformed 5886 Tumor immunology 6091

Oncogene Volume 21 keyword index

9093 Tumor-infiltrating Tumour angiogenesis Uracil-DNA glycosylase Vulval cancer 1876 8830 1309 8935 Tumor invasion 7839 Tumour growth 1370 Urethane 8486 WAP domain 2768 Tumor marker 4932 Tumour necrosis Urokinase plasminogen WAVE3 5967 factor-alpha (TNF-a) receptor 87 2447, 8149 6071 UV 44 6657, 954, 9008 Tumor progression 6684 Tumour promotion UV irradiation 1580, Wilms’ tumor 1009, Tumor promoter 1071, 2387 2441, 4481, 5844 2009, 6694 4266 Tumour suppressor 2119, UV sensitive syndrome Wilms’ tumour 5566, Tumor promoter PMA 2829, 2939, 4498 8949 7277 3213 Tumourigenesis 7121 UV-C 4065 WISP3 3172 Tumor promotion 3620 Two-step binding model UVA 7092 Wnt-4 2948 Tumor resistance genes 8967 UVB 2652, 2721 Wnt antagonist 878 6680 Tylosis 6395 UVC radiation 2079 Wnt pathway 4060, 7971 Tumor-specific Type II cells 6382 Wnt signaling 4646, 5548 expression 7991 Tyrosine kinase 22, 3562, v-Jun 6540 Wnt/wingless signaling Tumor stroma targeting 3889, 4351, 4374, 5175, v-erbA 2864 pathway 5861 4257 6255, 6992, 8541, 8568, V-ATPase 844 Wolffian duct derivatives Tumor-stromal 8584, 8643 v-fms 1079 1899 interaction 2009 Tyrosine kinase v-Myb 400, 1611 Wortmannin 5868 Tumor suppression 503, inhibitors 4885 V-SEA 697 WRN 2447 1196, 1616, 6779, 7471, Tyrosine kinase receptors v-src 1171, 2908 WT1 2948 8223, 8994 1785, 8334 virus 8379 WT1 1890 Tumor suppressor 708, Tyrosine kinases 8871 Vascular endothelial cell WT1 splicing 5566 1233, 1325, 1381, 2130, Tyrosine growth factor 4765 3112, 3796, 4089, 4788, 8871 Vascular endothelial cells Xpc mice 5704 5929, 7421, 7497, 7991, Tyrosine phosphory- 2805 Xenograft 3162, 7700 8351 lation 2347, 6488, 7524 Vascular tumor 2433 Xenopus laevis 1304 Tumor suppressor Tyrosol phosphorylation Vascular window model Xenopus oocyte 6425 gene(s) 1832, 2713, 6992 7011 3172, 3475, 3603, 4050, Vav 7720 8949 4345, 4462, 4822, 5016, UBC3 3978 VDAC 4944 XK469 4530 5358, 5631, 6049, 6835, Ubiquitin 3754, 5940, VDRE 3706 Xmrk 1668 6915, 6936, 5427, 8356 6829 VEGF 427, 1791, 2000, X-rays 7580 Tumor suppressor Ubiquitin ligase(s) 856, 2058, 2455, 2805, 2896, XRCC3 4176 proteins 761 1501, 6209 6307, 7730, 7945, 8817 Tumor suppressors 1848 Ubiquitin-mediated v-Ha-RAS 6657 Yeast 1411, 2051 Tumor targeting 4757 proteolysis 8515 VHL 929, 1117, 3507 Yeast functional assay Tumor xenograft 6255 Ubiquitination 1079, VHL 479 1641, 5704 Tumorigenesis 217, 282, 1707, 4363, 6209 VHL disease 1167 Yeast two-hybrid system 1800, 2815, 3190, 4549, UCN-01 1727 VHL gene 1167 3003 6299 UCS15A 2037 VHR 2573 YY1 8862 Tumorigenicity 3011, Ultrastruture 8149 Viral integration 8713 6801 uPA 7027, 7824 VLA-2 2864 z-VAD 6091 Tumors 541, 2029, uPA/uPAR 8128 v-myb oncogene 4663 Zac-1 coactivation 1469 5213, 7289, 8379, uPAR 2513 VNTR 769 Zinc finger 4237, 5783 8486 Uracil 8935 von Hippel-Lindau 1117 ZYG-1 6201

Oncogene