Hazardous Waste Management Plan
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Proceedings of the Indiana Academy of Science
The Nitrogen Dioxide Oxidation of Starch* J. W. Mench, with Ed F. Degering, Purdue University Although the literature contains over two hundred references to the oxidation of starch, little is known concerning the structures of the products because various oxidants may simultaneously attack one or more of the hydroxl groups to produce a complicated structure containing car- boxyl, aldehyde, and ketone groupings. An exception appears to result when periodic acid is used, since this oxidant seemingly exhibits a specificity towards parts of the carbohydrate molecule containing adja- 1 2 cent, secondary hydroxyl groupings. - The observations of Unruh, Yec- kel, and Kenyon,M that cellulose can be oxidized with nitrogen dioxide to a polyanhydroglucuronic acid, indicate that this reagent preferentially attacks the primary hydroxyl groups in certain glycosides. We have attempted to apply to starch both the static and cyclic method of oxidation reported by these men, in an effort to produce the alpha-linked polyanhydroglucuronic acids. However, the tendency of the powdered carbohydrate to pack made these procedures unsatisfactory, since the reactions were difficult to control and at least partial hydrolysis of the starch frequently occurred. We have found, however, that under suitable conditions, starch may be oxidized by nitrogen dioxide to produce a new type of oxidized starch containing, predominately, uronic acid residues. This point was con- firmed, qualitatively, by a positive beta-naphthol test,5 which indicated the presence of glucuronic acid, although attempts to hydrolyze the prod- ucts to glucuronic acid, and to prepare the cinchonine salt or oxime of this compound were without success. The procedure and diluent utilized in this work was suggested by the work of Maurer and Drefahl,6 who oxidized galactose, methyl gluco- side, and methyl galactoside with nitrogen dioxide in carbon tetrachloride or chloroform—obtaining mucic acid and the corresponding substituted uronic acids, respectively. -
Results of Long-Term Carcinogenicity Bioassay on Vinyl Acetate Monomer in Sprague-Dawley Rats
Results of Long-Term Carcinogenicity Bioassay on Vinyl Acetate Monomer in Sprague-Dawley Rats FRANCO MINARDI, FIORELLA BELPOGGI, MORANDO SOFFRITTI, ADRIANO CILIBERTI, MICHELINA LAURIOLA, ELISA CATTIN, AND CESARE MALTONI† Cancer Research Center, European Ramazzini Foundation for Oncology and Environmental Sciences, Bologna, Italy ABSTRACT: Vinyl acetate monomer (VAM) was administered in drinking water supplied ad libitum at doses of 5,000, 1,000, and 0 ppm (v/v) to 17-week-old Sprague-Dawley rats (breeders) and to 12-day embryos (offspring). Treatment lasted for 104 weeks; thereafter, animals were kept under control conditions until spontaneous death. VAM was found to cause an increase in total malig- nant tumors and in carcinomas and/or precursor lesions of the oral cavity, lips, tongue, esophagus, and forestomach. Based on these data, VAM must be con- sidered a multipotent carcinogen. KEYWORDS: vinyl acetate monomer; carcinogenicity; long-term bioassay; rat INTRODUCTION Vinyl acetate monomer (VAM) is an important compound in the plastics industry. VAM (C 4H6O2) has a molecular weight of 86.09. Industrial production of VAM started in the United States in 1928.1 VAM is produced mainly by two processes: (1) In a process used since the 1920s, acetylene and acetic acid are reacted in the vapor phase over a catalyst bed,2 (2) In another process, largely used since the 1970s, eth- ylene is reacted with acetic acid in the presence of oxygen.3 The world production of VAM is over 2.5 million tons per year.4 The only commercial use of VAM is in the production of polymers (polyvinyl ac- etate, polyvinyl alcohol, polyvinyl acetals) and copolymers (ethylene-vinyl acetate and polyvinyl-acetate chloride).3 Polyvinyl acetate is mainly used in adhesives for paper, wood, glass, metals, and porcelain. -
Sept. 4, 1962. MICHIJIRO AKABOSH ETAL 3,052,610 CONCENTRATION of ACETIC ACID Filed May 19, 1960
Sept. 4, 1962. MICHIJIRO AKABOSH ETAL 3,052,610 CONCENTRATION OF ACETIC ACID Filed May 19, 1960 INVENTORS MCHIJIRO AKABOSH KK UJ U RAGAM: BY KENSUKE O KUMA AttoRNEY 3,052,610 United States Patent Office Patented Sept. 4, 1962 2 1. acetate. Some of the vinyl acetate from the upper phase 3,052,610 is returned to the top of the distillation zone as reflux, CONCENTRATION OF ACETIC ACD in accordance with conventional distillation technique, Michijiro Akaboshi, Toyonaka City, and Kikuji Uragaini and the remainder is withdrawn as product. and Kensuke Okema, Toyama City, Japan, assignors to Particularly suitable as a source of vinyl acetate for Kurashiki Rayon Co., Ltd., Okayama Prefecture, the distillation operation referred to above is the vinyl Japan, a corporation of Japan acetate-acetic acid mixture which is produced in the syn Fied May 19, 1960, Ser. No. 30,384 thesis of vinyl acetate from acetylene and acetic acid. 6 Claims. (C. 202-42) Prior to its use for the production of polyvinyl acetate This invention relates to the concentration of aqueous O by polymerization, the vinyl acetate must be separated Solutions of acetic acid and is more particularly concerned from the acetic acid. In accordance with the invention, With a process for concentrating aqueous acetic acid solu this operation is combined with the acetic acid dehydrat tions which is effectively integrated with the manufac ing and concentrating operation so that two normally ture of polyvinyl alcohol. independent processing steps are effectively and efficiently In accordance with conventional practice, polyvinyl 5 combined into a single operation which produces sub alcohol is formed by the saponification or "alcoholysis' stantially pure vinyl acetate suitable for the production of polyvinyl acetate which, in turn, is formed by the poly of polyvinyl acetate, and an effectively concentrated or merization of vinyl acetate. -
Elimination of Galactaric Acid Catabolism by Using RNA Sequencing and CRISPR/Cas9 Joosu Kuivanen*†, Y.‑M
Kuivanen et al. Microb Cell Fact (2016) 15:210 DOI 10.1186/s12934-016-0613-5 Microbial Cell Factories RESEARCH Open Access Engineering Aspergillus niger for galactaric acid production: elimination of galactaric acid catabolism by using RNA sequencing and CRISPR/Cas9 Joosu Kuivanen*†, Y.‑M. Jasmin Wang† and Peter Richard Abstract Background: meso-Galactaric acid is a dicarboxylic acid that can be produced by the oxidation of D-galacturonic acid, the main constituent of pectin. Mould strains can be engineered to perform this oxidation by expressing the bacterial enzyme uronate dehydrogenase. In addition, the endogenous pathway for D-galacturonic acid catabolism has to be inactivated. The filamentous fungus Aspergillus niger would be a suitable strain for galactaric acid produc‑ tion since it is efficient in pectin hydrolysis, however, it is catabolizing the resulting galactaric acid via an unknown catabolic pathway. Results: In this study, a transcriptomics approach was used to identify genes involved in galactaric acid catabolism. Several genes were deleted using CRISPR/Cas9 together with in vitro synthesized sgRNA. As a result, galactaric acid catabolism was disrupted. An engineered A. niger strain combining the disrupted galactaric and D-galacturonic acid catabolism with an expression of a heterologous uronate dehydrogenase produced galactaric acid from D-galactu‑ ronic acid. The resulting strain was also converting pectin-rich biomass to galactaric acid in a consolidated bioprocess. Conclusions: In the present study, we demonstrated the use of CRISPR/Cas9 mediated gene deletion technology in A. niger in an metabolic engineering application. As a result, a strain for the efficient production of galactaric acid from D-galacturonic acid was generated. -
US EPA, Inert (Other) Pesticide Ingredients in Pesticide Products
Inert Ingredients ordered by CAS Number Updated August 2004 CAS PREFIX NAME List No. 50-21-5 Lactic acid 4B 50-70-4 Sorbitol 4A 50-81-7 L- Ascorbic acid 4A 50-99-7 Dextrose 4A 51-03-6 Piperonyl butoxide 3 51-05-8 Procaine hydrochloride 3 51-55-8 Atropine 3 52-51-7 2- Bromo-2-nitro-propane-1,3-dio 3 54-21-7 Sodium salicylate 3 56-81-5 Glycerol (glycerin) 1,2,3 propanetriol 4A 56-86-0 L- Glutamic acid 3 56-95-1 Chlorhexidine diacetate 3 57-10-3 Hexadecanoic acid 4A 57-11-4 Stearic acid 4A 57-13-6 Urea 4A 57-48-7 D- Fructose 4B 57-50-1 Sugar 4A 57-55-6 Propylene glycol 4B 57-88-5 (3.beta.)- Cholest-5-en-3-ol 4B 58-08-2 1H- Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl- 4B 58-56-0 Thiamine mononitrate 4B 58-85-5 Biotin 3 58-86-6 D- Xylose 4B 58-95-7 Vitamin E acetate 3 59-30-3 Folic acid 4B 59-40-5 N-(2- Quinoxalinyl)sulfanilide 3 59-67-6 Nicotinic acid 3 60-00-4 Ethylenediaminetetraacetic acid (EDTA) 4B 60-12-8 Benzeneethanol 3 60-29-7 Ethane, 1,1'-oxybis- 3 60-33-3 Linoleic acid 3 61-73-4 C.I. Basic Blue 9 3 62-33-9 Ethylenediaminetetraacetic acid (EDTA), calcium4B 62-54-4 Acetic acid, calcium salt 4A 63-42-3 D-(+)-Lactose 4A 63-68-3 L- Methionine 4B 64-02-8 Ethylenediaminetetraacetic acid (EDTA), tetraso4B 64-17-5 Ethanol 4B 64-18-6 Formic acid 3 64-19-7 Acetic acid 4B 64-86-8 Colchicine 3 65-85-0 Benzoic acid 4B 66-71-7 1,10- Phenanthroline 3 67-03-8 Thiamin hydrochloride 3 67-43-6 1,1,4,7,7- Diethylenetriaminepentaacetic acid 3 67-48-1 Choline chloride 4B 67-56-1 Methyl alcohol 3 67-63-0 2- Propanol 4B 67-64-1 Acetone 3 67-68-5 Dimethyl -
THERMAL DEGRADATION of Pvac
Journal of the University of J.Chemical Blazevska-Gilev, Technology D. Spaseskaand Metallurgy, 40, 4, 2005, 287-290 THERMAL DEGRADATION OF PVAc J. Blazevska-Gilev, D. Spaseska Faculty of Technology and Metallurgy, Received 20 October 2005 Ss Cyril and Methodius University, Accepted 15 November 2005 P.O. Box 580, MK-1001 Skopje, Republic of Macedonia, E-mail: [email protected] ABSTRACT The kinetics of decomposition of plastics are interesting from different points of view, i.e. evolution of harmful substances during fires or waste incineration, recovering of chemical raw materials from plastic refuses and designing of recycling procedures. Non isothermal or dynamic thermogravimetry (TGA) has been used for kinetic study of the thermally activated process of polyvinyl acetate (PVAc), heating by two different rates up to around 723 K. As the easily measured weight changes of the samples in the defined thermal conditions are a suitable sensor for their structural and chemical changes, by means of some methods like Gropjanov-Abbakumov,s one, the useful information for identifying the formal kinetic parameters of the investigated processes taking place in the course of thermal treatment have been obtained. The thermal variation of the rate constant as well as the kinetic equations for the examined process depending on the investigated parameters have been derived. Keywords: polyvinyl acetate, thermal degradation, degradation kinetics. INTRODUCTION mally degrades under vacuum at an appreciable rate at temperatures above 500 K. The mechanisms of ther- Polyvinyl acetate (PVAc) is known to be one of mal degradation of PVAc is very complex process in- the most important commercial polymers as a result cluding, among others, the following reactions: chain of its low cost and high performance of the products, fission, radical recombination, carbon hydrogen single combined with the wide range of properties. -
The Production of Vinyl Acetate Monomer As a Co-Product from the Non-Catalytic Cracking of Soybean Oil
Processes 2015, 3, 619-633; doi:10.3390/pr3030619 OPEN ACCESS processes ISSN 2227-9717 www.mdpi.com/journal/processes Article The Production of Vinyl Acetate Monomer as a Co-Product from the Non-Catalytic Cracking of Soybean Oil Benjamin Jones, Michael Linnen, Brian Tande and Wayne Seames * Department of Chemical Engineering, University of North Dakota, 241 Centennial Dr., Stop 7101 Grand Forks, ND 58202-7101, USA; E-Mails: [email protected] (B.J.); [email protected] (M.L.); [email protected] (B.T.) * Author to whom correspondence should be addressed; E-Mail: [email protected]; Tel.: +1-701-777-2958; Fax: +1-701-777-3773. Academic Editor: Bhavik Bakshi Received: 30 June 2015/ Accepted: 7 August 2015 / Published: 14 August 2015 Abstract: Valuable chemical by-products can increase the economic viability of renewable transportation fuel facilities while increasing the sustainability of the chemical and associated industries. A study was performed to demonstrate that commercial quality chemical products could be produced using the non-catalytic cracking of crop oils. Using this decomposition technique generates a significant concentration of C2−C10 fatty acids which can be isolated and purified as saleable co-products along with transportation fuels. A process scheme was developed and replicated in the laboratory to demonstrate this capability. Using this scheme, an acetic acid by-product was isolated and purified then reacted with ethylene derived from renewable ethanol to generate a sample of vinyl acetate monomer. This sample was assessed by a major chemical company and found to be of acceptable quality for commercial production of polyvinyl acetate and other products. -
Vinyl Acetate
Vinyl acetate 108-05-4 Hazard Summary Vinyl acetate is primarily used as a monomer in the production of polyvinyl acetate and polyvinyl alcohol. Acute (short-term) inhalation exposure of workers to vinyl acetate has resulted in eye irritation and upper respiratory tract irritation. Chronic (long-term) occupational exposure did not result in any severe adverse effects in workers; some instances of upper respiratory tract irritation, cough, and/or hoarseness were reported. Nasal epithelial lesions and irritation and inflammation of the respiratory tract were observed in mice and rats chronically exposed by inhalation. No information is available on the reproductive, developmental, or carcinogenic effects of vinyl acetate in humans. An increased incidence of nasal cavity tumors has been observed in rats exposed by inhalation. In one drinking water study, an increased incidence of tumors was reported in rats. EPA has not classified vinyl acetate for carcinogenicity. Please Note: The main sources of information for this fact sheet are EPA's Integrated Risk Information System (IRIS) (2), which contains information on inhalation chronic toxicity of vinyl acetate and the RfC, and the Agency for Toxic Substances and Disease Registry's (ATSDR's) Toxicological Profile for Vinyl Acetate. (1) Uses Vinyl acetate is primarily used as a monomer in the production of polyvinyl acetate and polyvinyl alcohol.(1) Vinyl acetate is also used as a raw material in the production of other chemicals, in adhesives, water-based paints, nonwoven textile fibers, textile sizings and finishes, paper coatings, inks, films, and lacquers. (1,2) Sources and Potential Exposure Exposure is most likely to occur in the workplace, where individuals may be occupationally exposed to vinyl acetate via inhalation or dermal contact during its manufacture or use. -
Trichoderma Reesei Toni Paasikallio, Anne Huuskonen and Marilyn G
Paasikallio et al. Microb Cell Fact (2017) 16:119 DOI 10.1186/s12934-017-0736-3 Microbial Cell Factories RESEARCH Open Access Scaling up and scaling down the production of galactaric acid from pectin using Trichoderma reesei Toni Paasikallio, Anne Huuskonen and Marilyn G. Wiebe* Abstract Background: Bioconversion of D-galacturonic acid to galactaric (mucic) acid has previously been carried out in small scale (50–1000 mL) cultures, which produce tens of grams of galactaric acid. To obtain larger amounts of biologically produced galactaric acid, the process needed to be scaled up using a readily available technical substrate. Food grade pectin was selected as a readily available source of D-galacturonic acid for conversion to galactaric acid. Results: We demonstrated that the process using Trichoderma reesei QM6a Δgar1 udh can be scaled up from 1 L to 1 10 and 250 L, replacing pure D-galacturonic acid with commercially available pectin. T. reesei produced 18 g L− galac- 1 1 taric acid from food-grade pectin (yield 1.00 g [g D-galacturonate consumed]− ) when grown at 1 L scale, 21 g L− 1 1 galactaric acid (yield 1.11 g [g D-galacturonate consumed]− ) when grown at 10 L scale and 14 g L− galactaric acid 1 (yield 0.77 g [g D-galacturonate consumed]− ) when grown at 250 L scale. Initial production rates were similar to those observed in 500 mL cultures with pure D-galacturonate as substrate. Approximately 2.8 kg galactaric acid was precipitated from the 250 L culture, representing a recovery of 77% of the galactaric acid in the supernatant. -
Sigma Sugars and Carbohydrates
Sigma Sugars and Carbohydrates Library Listing – 614 spectra This library represents a material-specific subset of the larger Sigma Biochemical Condensed Phase Library relating to sugars and carbohydrates found in the Sigma Biochemicals and Reagents catalog. Spectra acquired by Sigma-Aldrich Co. which were examined and processed at Thermo Fisher Scientific. The spectra include compound name, molecular formula, CAS (Chemical Abstract Service) registry number, and Sigma catalog number. Sigma Sugars and Carbohydrates Index Compound Name Index Compound Name 255 (+/-)-Epi-inosose-2 475 2,3,4,6-Tetra-O-methyl-D-glucopyranose 468 1,2,3,4-Tetra-O-acetyl-6- 487 2,3,5-Tri-O-benzoyl-1-O-p-nitrobenzoyl diphenylphosphoryl-b-D-manopyranose D-ribofuranoside 471 1,2,3,4-Tetra-O-acetyl-b-D- 490 2,3,5-Tri-O-benzyl-1-O-p-nitrobenzoyl- glucopyranose D-arabinofuranoside 472 1,2,3,5-Tetra-O-acetyl-b-D-ribofuranose 488 2,3,5-Tri-O-benzyl-b-D-arabinofuranose 473 1,2,3,5-Tetra-O-benzoyl-a-D- 489 2,3,5-Tri-O-benzyl-b-L-arabinofuranose xylofuranose 107 2,3-Dehydro-2-deoxy-N- 258 1,2-O-Isopropylidene-3-O-benzyl-rac- acetylneuraminic acid glycerol 142 2,3-Diphospho-D-glyceric acid, 261 1,2-O-Isopropylidene-5-O-p-tosyl-a-D- penta(CHA) salt xylofuranose 143 2,3-Diphospho-D-glyceric acid, 259 1,2-O-Isopropylidene-D-glucofuranose pentasodium salt 262 1,2-O-Isopropylidene-D-xylofuranose 144 2,3-Diphospho-D-glyceric acid, tris salt 135 1,2:3,4-Di-O-isopropylidene-D- 260 2,3-O-Isopropylidene-b-D- galactopyranose ribofuranosylamine, tosylate salt 141 1,2:3,5-Di-O-isopropylidene-D- -
67160 Polyvinyl Acetate Copolymer
Material Safety Data Sheet According to regulation (EC) No. 1907/2006 (REACH) 67160 Polyvinyl Acetate Copolymer Page 1 Revised edition: 27.05.2015 Version: 1.2 Printed: 07.10.2016 1. Identification of the Substance/Mixture and of the Company/Undertaking 1. 1. Product Identifier Product Name: Polyvinyl Acetate Copolymer Article No.: 67160 1. 2. Relevant identified Uses of the Substance or Mixture and Uses advised against Identified uses: Raw material for industrial purposes. Adhesive, coating material, primer Binding agent Uses advised against: 1. 3. Details of the Supplier of the Safety Data Sheet (Producer/Importer) Company: Kremer Pigmente GmbH & Co. KG Address: Hauptstr. 41-47, 88317 Aichstetten, Germany Tel./Fax.: Tel +49 7565 914480, Fax +49 7565 1606 Internet: www.kremer-pigmente.de EMail: [email protected] Importer: -- 1. 4. Emergency No. Emergency No.: +49 7565 914480 (Mon-Fri 8:00 - 17:00) 2. Hazards Identification 2. 1. Classification of the Substance or Mixture Classification according to Regulation (EC) No. 1272/2008 (CLP/GHS) Flammable liquids, hazard category 2 Eye irritation, hazard category 2 Specific Target Organ Toxicity (single exposure), hazard category 3 H225 Highly flammable liquid and vapour. Cat.: 2 H319 Causes serious eye irritation. Cat.: 2 H336 May cause drowsiness or dizziness. Cat.: 3 Classification according to Directive No. 67/548/EC or No. 1999/45/EC Flammable (F) R11 Highly flammable Irritating (Xi) R36 Irritating to eyes. R66 Repeated exposure may cause skin dryness or cracking. Safety Phrases: Possible Environmental Effects: 2. 2. Label Elements Classification according to Regulation next page: 2 Material Safety Data Sheet According to regulation (EC) No. -
VINYLACETATE Production out of ACETYLENE
ISSN: 2350-0328 International Journal of Advanced Research in Science, Engineering and Technology Vol. 6, Issue 12 , December 2019 VINYLACETATE Production Out of ACETYLENE Omanov B.Sh., Fayzullaev N.I., Khatamova M.S. Navoi State Pedagogical Institute, Samarkand State University, Navoi State Pedagogical Institute, Uzbekistan ABSTRACT: In the study, a nanocatalyst with high efficiency, activity and selectivity has been created for the catalytic acetylated reaction of acetylene on the basis of Sol-gel technology. The impact of various factors (temperature, volume velocity, С2Н2:СН3СООН mol ratio, the way of preparation of catalysts etc.) on vinyl acetate sulphide, selection process and conversion of starting material with the presence of a catalyst with the highest catalytic activity (ZnO)x∙(CdO)y∙(ZrO2)z/keramzite style has been studied. As a result of the research, the mechanism and kinetic equation of vinyl acetate steam phase is proposed. Based on the results obtained, the kinetic model has been created, on the basis of this kinetic model, the process of vinyl acetate synthesis has been optimized. KEY WORDS: Acetic acid, Acetylene, Catalyst, Material balance, Optimization, Sol-gel technology, Vinyl acetate. I.INTRODUCTION The most important vinyl acetate is the vinyl acetate among oxygen-containing compounds that can be extracted from the major organic and petrochemical industries. Vinyl acetate is widely used in industry as a monomer. One of the important properties of vinyl acetate is its polymerization. Polyvinyl acetate, polyvinyl alcohol and polyvinyl-acetal are extensively used among vinyl acetate polymer products produced from vinyl acetate. Polyvinyl acetate has high adhesion and elasticity properties, which is highly evaporative.