i Current Cancer Drug Targets, 2019, Vol. 19, No. 2 Graphical Abstracts
Graphical Abstracts
Current Cancer Drug Targets, 2019, Vol. 19, No. 2 82 Epigenetics in Metastatic Breast Cancer: Its Regulation and Implications in Diagnosis, Prognosis and Therapeutics
Yuan Seng Wu, Zhong Yang Lee, Lay-Hong Chuah, Chun Wai Mai and Siew Ching Ngai*
*School of Biosciences, Faculty of Science, University of Nottingham Malaysia Campus, Selangor, Malaysia
Nucleoside analogues Non-nucleoside analogues
HH N
N N Inhibition
O N DNA DNMT mRNA MG98 HO O OH HO
5-azacytidine
Incorporation Inhibition HH DNMT N Active site N N
O N
O OH O HO H OH
HO 5-aza-2-deocytidine N O OH N O N N H N H OH OH N O O H OH O O H Hydralazine OH HO O Epigallocatechin-3-gallate
Zebularine
Current Cancer Drug Targets, 2019, Vol. 19, No. 2 101 Malignant Intracranial High Grade Glioma and Current Treatment Strategy
Xiang Zhang*, Wei Zhang, Xing-Gang Mao, Wei-Dong Cao, Hai-Ning Zhen and Shi-Jie Hu *Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi’an, People’s Republic of China
Ommaya reservoir BBB disruption by infusion of mannitol Intra-Arterial Injections tumor resection- created cavity
Tumor chemotherapeutic agents
Gliadel wafers tumor resection- created cavity
Graphical Abstracts Current Cancer Drug Targets, 2019, Vol. 19, No. 2 ii
Current Cancer Drug Targets, 2019, Vol. 19, No. 2 109 Cellular Senescence-inducing Small Molecules for Cancer Treatment
Peng Liu, Ziwen Lu, Yanfang Wu, Dongsheng Shang, Zhicong Zhao, Yanting Shen, Yafei Zhang, Feifei Zhu, Hanqing Liu* and Zhigang Tu* *Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu 212013, China; *School of Pharmacy, Jiangsu Uni- versity, Zhenjiang, Jiangsu 212013, China
# & # "'()+ # # # !. / # # # 0 # # # 11 /2 # # ! # 0 3 3 0! # # # 0 3 3 0)0 4 # # # ! 6 # "# $% # ) $ # ) 41 $ # # 0 # # 0 3 # # 0 ! # # . K. ! # # & 1 I # # O 2$ 1/ @
# # & 47" @ # # # 4 /882 7 0 # # 4 ; + +8 9 +: # # # " 4 3 # 0@ 3 " =3 > # 6 # # ;0 B0! ? %: = > # # # 0 022 9 0 022% / # # ! . # $ 3 # # ; =;" > # # $ # ; & # =!" 8 > # E?11% # & < Current Cancer Drug Targets, 2019, Vol. 19, No. 2 120 A Comprehensive Review on Ethnomedicinal, Pharmacological and Phytochemical Basis of Anti- cancer Medicinal Plants of Pakistan
Muhammad Furqan Akhtar*, Ammara Saleem, Alamgeer and Mohammad Saleem *Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, Pakistan
Defect in DNA Polyphenol damage repair genes Resveratrol, Mutations in proto- Genistein, DNA Damage in
Initiation of Carcinogenesis oncogenes and Normal Cells Flavonoids
Luteolin,
Betulinic Acid Genetic Cell Cycle Polyphenols, Instability Resveratrol, Inhibition Genistein, Luteolin, Betulinic Acid, Pomegranate, Inhibition of Genistein, Loss of control on Polyphenols, Proliferation Apoptosis Resveratrol, Genistein, Malignant Luteolin, Betulinic Cells Acid,Polyphenols, Resveratrol, Genistein,Luteolin, Progression of Cancers
Pomegranate, Genistein, Taraxacum omcinale, puncia granatum and Glycyrrhiza glabra Clonal Evasion of Angiogenesis Proliferation Immune System Spread of Cancers
Genistein, Mentha spicata,
Taraxacum officinale, Metastasis and Punica granatum Secondary tumor
Anticancer Activity of Herbal Medicines and their active compounds iii Current Cancer Drug Targets, 2019, Vol. 19, No. 2 Graphical Abstracts
Current Cancer Drug Targets, 2019, Vol. 19, No. 2 152 Cordycepin Downregulates Cdk-2 to Interfere with Cell Cycle and Increases Apoptosis by Gener- ating ROS in Cervical Cancer Cells: in vitro and in silico Study
Mousumi Tania, Jakaria Shawon, Kazi Saif, Rudolf Kiefer, Mahdi Safaei Khorram, Mohammad A. Halim* and Md. Asaduzzaman Khan* *Division of Molecular Cancer Biology, The Red-Green Research Center, Dhaka, Bangladesh; *Key Laboratory of Epigenetics and Oncology, The Research Center for Preclinical Medicine, Southwest Medical University, Luzhou, Sichuan, China NH2
N N HO N N Cordycepin O
OH Cancer cell
ROS
Cdk-2 Increased cellular Cyclin-E1 apoptosis Cyclin-A2
Cell cycle control