Objectives Body Fluid Compartments
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5/6/2015 Life-Threatening Sodium Imbalances: Identification and Treatment Karen Kopan DNP, APN, ACNP-BC NorthShore Evanston Hospital Objectives • Distinguish between cerebral salt wasting (CSW), syndrome of inappropriate antidiuretic hormone (SIADH) and diabetes insipidus (DI) • Differentiate the treatments for each disease process Body Fluid Compartments Total Body Water 50% body weight in women, 60% body weight in men 1/3 is Extracellular fluid volume 2/3 is Intracellular (ECFV) fluid volume (ICFV) ¾ is Interstitial fluid ¼ is Plasma volume volume (intravascular) 1 5/6/2015 Sodium (Na) • Normal concentration of extracellular Na 135-145 mEq/L • Keeps the extracellular fluid volume (ECFV) within reasonable limits Sodium Status and Water Status Sodium Water • Determines volume of the • Determines serum sodium ECF compartment concentration • Is this a sodium problem? • Is this a water problem? • Massive pedal edema and • 34yo M with Na ascites, Na 140 mEq/L concentration of 125 mEq/L • Problem with total body Na • Problem with water control control • Excess of water relative to • Excess of ECFV from sodium in ECFV abnormal total body sodium 2 5/6/2015 Sodium (Na) • If Na increases in the extracellular fluid (ECF), so will the extracellular fluid volume (ECFV) • If Na decreases in the extracellular fluid (ECF), so will the extracellular fluid volume (ECFV) Preston, RA. (2011). Acid-base, fluids, and electrolytes made ridiculously simple (2 nd ed.). Miami, FL : MedMaster, Inc. ECFV overload states Edema – Congestive heart failure – Cirrhosis of the liver – Nephrotic syndrome ↑Na in ECF compartment → ECFV overload Clinically: pleural effusions, pulmonary edema, ascites Preston, RA. (2011). Acid-base, fluids, and electrolytes made ridiculously simple (2 nd ed.). Miami, FL : MedMaster, Inc. Decreased ECFV states • Poor skin turgor, tachycardia, orthostatic • Volume depletion • Too little sodium in the ECF compartment Preston, RA. (2011). Acid-base, fluids, and electrolytes made ridiculously simple (2 nd ed.). Miami, FL : MedMaster, Inc. 3 5/6/2015 Regulation of total body Na • Juxtaglomerular cells in the kidney • Volume receptors in the great veins and atria • Pressure receptors in the aorta and carotid sinus THEREFORE…when ECFV increases, mechanisms are in place to increase Na excretion to prevent ECFV overload AND…when ECFV decreases, pathways promote sodium retention by the kidneys to decrease ECFV depletion ECF Sodium Concentration • Measured Na tells us about the water relative to the amount of sodium • NOT the total amount of ECF Na or size of ECFV Sodium Concentration Abnormalities in Na concentration = abnormalities in regulation of water in ECF compartment. 4 5/6/2015 Tonicity • Ability of all the solutes to generate osmotic forces that cause water movement from one compartment to another • To increase ECF tonicity, solute must be unable to cross into intracellular compartment • Water then moves from intracellular to extracellular to establish equilibrium Preston, RA. (2011). Acid-base, fluids, and electrolytes made ridiculously simple (2 nd ed.). Miami, FL : MedMaster, Inc. Tonicity Tonicity and Brain Cells • Hyponatremia, decreased tonicity and water moves to intracellular compartment; brain cell swelling • Hypernatremia, increased tonicity and water moves to extracellular compartment; brain cell shrinkage • Rapid increase in ECFV tonicity leads to water leaving the brain and brain shrinkage Preston, RA. (2011). Acid-base, fluids, and electrolytes made ridiculously simple (2 nd ed.). Miami, FL : MedMaster, Inc. 5 5/6/2015 Regulation of Serum Sodium Oral water intake • thirst mechanism • water availability Renal water regulation; adjusts water excretion • adequate glomerular filtration rate (GFR) • adequate delivery of glomerular filtrate • intact concentrating and diluting • appropriate on and off of ADH • ADH responsiveness of kidneys Preston, RA. (2011). Acid-base, fluids, and electrolytes made ridiculously simple (2 nd ed.). Miami, FL : MedMaster, Inc. Adequate glomerular filtration rate (GFR) Flow rate of filtered fluid through the kidney (mL/min) Intact concentrating and diluting 6 5/6/2015 Appropriate on and off of ADH and ADH responsiveness of kidneys Antidiuretic Hormone (ADH) • AKA vasopressin • Increases collecting duct permeability to water • Facilitates water reabsorption; retains water • Synthesized in the hypothalamus • Stored in the posterior pituitary Preston, RA. (2011). Acid-base, fluids, and electrolytes made ridiculously simple (2 nd ed.). Miami, FL : MedMaster, Inc. ADH regulation Secreted in response to: Increased plasma osmolality (primarily) Decreased plasma volume Water is reabsorbed when plasma osmolality is high 7 5/6/2015 Renal Water Regulation Review Control of Na intake and output determines ECFV size ↓ Abnormal ECFV size is due to a problem with sodium control mechanism Control of water intake and output determines Na concentration ↓ Abnormal Na is due to a problem with water control mechanism 8 5/6/2015 Hyponatremia (Na <135 mEq/L) • Excess water relative to sodium • Water moves to intracellular space to equilibrate • Brain tissue swells • Na <125 mEq/L: Anorexia, nausea, malaise, headache, lethargy, confusion, agitation, obtundation • Severe cerebral edema: Seizures, coma, respiratory arrest, death Lanken, PN et. al. (2014). The Intensive Care Unit Manual (2 nd ed.) Philadelphia, PA: Elsevier, Inc. Morbidity and Mortality • Influenced by magnitude, rate of development • At greatest risk – Very young and old – Premenopausal women – Patients with pneumonia – Patients with heart failure – Cirrhotic patients – Chronic alcoholics • Symptoms resolve with correction • Unless moderate to severe development in 24 hours – Residual neuro deficits – Mortality as high as 50% Lanken, PN et. al. (2014). The Intensive Care Unit Manual (2 nd ed.) Philadelphia, PA: Elsevier, Inc. Symptomatic Hyponatremia Treatment • Carefully correct Na concentration toward normal • Raise body fluid tonicity and shift water out of intracellular space • Find and treat underlying cause The shorter the time course of development, the more severe the symptoms and therefore the more urgent is the initiation of therapy Preston, RA. (2011). Acid-base, fluids, and electrolytes made ridiculously simple (2 nd ed.). Miami, FL : MedMaster, Inc. 9 5/6/2015 Medical emergency • Acute, severely symptomatic hyponatremia • Immediate treatment in intensive care unit • Permanent neurologic sequelae or death may occur if not addressed immediately • Overly rapid correction has been associated with central pontine myelinolysis or when extrapontine, osmotic demyelinization syndrome (ODS) Preston, RA. (2011). Acid-base, fluids, and electrolytes made ridiculously simple (2 nd ed.). Miami, FL : MedMaster, Inc. Central pontine myelinolysis and ODS • Destruction of myelin sheath surrounding nerve cells in the brain stem • Manifests as dysarthria, dysphagia, incoordination, quadriplegia and in severe cases, coma • Increase Na by no more than 10 mEq/L in the first 24 hours • No more than 18 mEq/L in first 48 hours (rate of approx. 0.5 mEq/L per hour) Treatment (continued) • Best accomplished with 3% saline • Central line for 3% and frequent blood draws • 70kg, TBW 35 L (50% body weight if not obese or grossly edematous) • The amount needed to raise serum sodium by 10 mEq/L is 350 mEq (10 mEq/L X 35 L) • 3% has Na concentration 513 mEq/L • Therefore, 680 mL of 3% saline would be given in first 24 hours (350/513 X 1000ml) • Measure serum Na every 2 hours 10 5/6/2015 Case #1 What’s the problem? Hyponatremia, Normal ECFV Abnormal water control Water excess relative to sodium Syndrome of inappropriate antidiuretic hormone (SIADH) • Most common cause of hyponatremia in hospitalized patients • Abnormal ↑ in pituitary ADH secretion; reabsorbs more water • Therefore, hypotonic • The kidney cannot excrete excess water Hypotonic hyponatremia SIADH Findings • Na <135 mEq/L • Low serum osmolality • Urine osmolality inappropriately higher than serum osmolality (usually >300 mOsm/L)* • Urine Na >30 mmol/L** * Normal urine osmolality 300-900 mOsm/L **Normal urine Na 20 mEq/L Preston, RA. (2011). Acid-base, fluids, and electrolytes made ridiculously simple (2 nd ed.). Miami, FL : MedMaster, Inc. 11 5/6/2015 Medications that can cause SIADH • Amitriptyline • Carbamazepine • Chlorpropamide • Clofibrate • Cyclophosphamide • Haloperidol • Narcotics • Nicotine • Nonsteroidal anti-inflammatory drugs • Serotonin-reuptake inhibitors (Fluoxetine, Paroxetine, Sertraline, Citalopram, Trazodone) • Thiothixene • Thioridazine • Vincristine Preston, RA. (2011). Acid-base, fluids, and electrolytes made ridiculously simple (2 nd ed.). Miami, FL : MedMaster, Inc. Treatment of SIADH • Water restriction and identify underlying condition • Withhold medications that impair water excretion • Consider increasing solute intake (NaCl tabs) or agents that counteract ADH action, demeclocycline Preston, RA. (2011). Acid-base, fluids, and electrolytes made ridiculously simple (2 nd ed.). Miami, FL : MedMaster, Inc. 12 5/6/2015 Cerebral Salt Wasting (CSW) • First described in the 1950’s • Questioned after SIADH identified in 1957 • Both conditions occur with head trauma, intracranial or metastatic neoplasm, carcinomatous or infectious meningitis, subarachnoid hemorrhage (SAH) and central nervous system surgery • Treatments are different Mime, J et al. (2010). Hyponatremia-what is cerebral salt wasting? Clinical Medicine, 14, 62-65. CSW findings • Na <135 mEq/L • Low serum osmolality • High urine