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Uveal Involvement in Marburg Virus Disease B
Br J Ophthalmol: first published as 10.1136/bjo.61.4.265 on 1 April 1977. Downloaded from British Journal of Ophthalmology, 1977, 61, 265-266 Uveal involvement in Marburg virus disease B. S. KUMING AND N. KOKORIS From the Department of Ophthalmology, Johannesburg General Hospital and University of the Witwatersrand SUMMARY The first reported case of uveal involvement in Marburg virus disease is described. 'Ex Africa semper aliquid novi'. Two outbreaks of Marburg virus disease have been Rhodesia and had also been constantly at his documented. The first occurred in Marburg and bedside till his death. Lassa fever was suspected and Frankfurt, West Germany, in 1967 (Martini, 1969) she was given a unit of Lassa fever convalescent and the second in Johannesburg in 1975 (Gear, serum when she became desperately ill on the fifth 1975). This case report describes the third patient day. She also developed acute pancreatitis. Within in the Johannesburg outbreak, who developed an 52 hours she made a dramatic and uneventful anterior uveitis. The cause of the uveitis was proved recovery. Her illness mainly affected the haema- to be the Marburg virus by identiying it in a tissue topoietic, hepatic, and pancreatic systems. culture of her aqueous fluid. The subject of this report was a nurse who had helped to nurse patients 1 and 2. Nine days after the Case report death ofthe first patient she presented with lower back pain and high fever. She developed hepatitis, a mild Before describing the case history of the patient the disseminated intravascular coagulation syndrome, events leading to her contracting the disease must successfully treated with heparin, and the classical be briefly described. -
As a Model of Human Ebola Virus Infection
Viruses 2012, 4, 2400-2416; doi:10.3390/v4102400 OPEN ACCESS viruses ISSN 1999-4915 www.mdpi.com/journal/viruses Review The Baboon (Papio spp.) as a Model of Human Ebola Virus Infection Donna L. Perry 1,*, Laura Bollinger 1 and Gary L.White 2 1 Integrated Research Facility, Division of Clinical Research, NIAID, NIH, Frederick, MD, USA; E-Mail: [email protected] 2 Department of Pathology, University of Oklahoma Baboon Research Resource, University of Oklahoma, Ft. Reno Science Park, OK, USA; E-Mail: [email protected] * Author to whom correspondence should be addressed; E-Mail: [email protected]; Tel.: +1-301-631-7249; Fax: +1-301-619-5029. Received: 8 October 2012; in revised form: 17 October 2012 / Accepted: 17 October 2012 / Published: 23 October 2012 Abstract: Baboons are susceptible to natural Ebola virus (EBOV) infection and share 96% genetic homology with humans. Despite these characteristics, baboons have rarely been utilized as experimental models of human EBOV infection to evaluate the efficacy of prophylactics and therapeutics in the United States. This review will summarize what is known about the pathogenesis of EBOV infection in baboons compared to EBOV infection in humans and other Old World nonhuman primates. In addition, we will discuss how closely the baboon model recapitulates human EBOV infection. We will also review some of the housing requirements and behavioral attributes of baboons compared to other Old World nonhuman primates. Due to the lack of data available on the pathogenesis of Marburg virus (MARV) infection in baboons, discussion of the pathogenesis of MARV infection in baboons will be limited. -
The Hemorrhagic Fevers of Southern Africa South African Institute For
THE YALE JOURNAL OF BIOLOGY AND MEDICINE 55 (1982), 207-212 The Hemorrhagic Fevers of Southern Africa with Special Reference to Studies in the South African Institute for Medical Research J.H.S. GEAR, M.D. National Institute for Virology, Johannesburg, South Africa Received April 19, 1982 In this review of studies on the hemorrhagic fevers of Southern Africa carried out in the South African Institute for Medical Research, attention has been called to occurrence of meningococcal septicemia in recruits to the mining industry and South African Army, to cases of staphylococcal and streptococcal septicemia with hemorrhagic manifestations, and to the occurrence of plague which, in its septicemic form, may cause a hemorrhagic state. "Onyalai," a bleeding disease in tropical Africa, often fatal, was related to profound throm- bocytopenia possibly following administration of toxic witch doctor medicine. Spirochetal diseases, and rickettsial diseases in their severe forms, are often manifested with hemorrhagic complications. Of enterovirus infections, Coxsackie B viruses occasionally caused severe hepa- titis associated with bleeding, especially in newborn babies. Cases of hemorrhagic fever presenting in February-March, 1975 are described. The first out- break was due to Marburg virus disease and the second, which included seven fatal cases, was caused by Rift Valley fever virus. In recent cases of hemorrhagic fever a variety of infective organisms have been incriminated including bacterial infections, rickettsial diseases, and virus diseases, including Herpesvirus hominis; in one patient, the hemorrhagic state was related to rubella. A boy who died in a hemorrhagic state was found to have Congo fever; another pa- tient who died of severe bleeding from the lungs was infected with Leptospira canicola, and two patients who developed a hemorrhagic state after a safari trip in Northern Botswana were infected with Trypanosoma rhodesiense. -
A Methodology for Complex Agricultural Development Projects
Systemic Impact Evaluation: A Methodology for Complex Agricultural Development Projects. The Case of a Contract Farming Project in Guinea Jocelyne Delarue, Hubert Cochet To cite this version: Jocelyne Delarue, Hubert Cochet. Systemic Impact Evaluation: A Methodology for Complex Agri- cultural Development Projects. The Case of a Contract Farming Project in Guinea. The European Journal of Development Research, 2013, 25 (5), p.778-796. 10.1057/ejdr.2013.15. halshs-01374496 HAL Id: halshs-01374496 https://halshs.archives-ouvertes.fr/halshs-01374496 Submitted on 7 May 2020 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Original Article Systemic Impact Evaluation: A Methodology for Complex Agricultural Development Projects. The Case of a Contract Farming Project in Guinea Jocelyne Delaruea and Hubert Cochetb aAgence Française de Développement, Evaluation and Capitalization Unit, Paris, France. E-mail: [email protected] bAgro Paris Tech, Comparative Agriculture and Agricultural Development Research Unit, Paris, France. E-mail: [email protected] Abstract This article presents a mixed-method approach used to analyse the impact of a complex agricultural development project, the SOGUIPAH (Guinean Oil Palms and Rubber Company) project designed to promote oil palm and rubber cultivation in Guinea. -
USCRI Policy Snapshot
USCRI Policy Snapshot DISPLACEMENT IN THE CLIMATE CHANGE ERA JUNE 2020 A situational update on the Democratic Republic of the Congo after volcanic eruption near Goma Daniel Salazar Eruption and Immediate Aftermath On May 22, 2021, Mount Nyiragongo erupted near the densely populated city of Goma, the capital of the North Kivu province in the eastern Democratic Republic of the Congo. Lava flows advanced toward neighborhoods north of the city’s airport.1 Shortly after the volcanic eruption, officials were concerned about displacement to and from Sake, an area northwest of Goma that is prone to cholera outbreaks.2 With cases recorded in Sake before the eruption, officials worried that displacement from the eruption may fuel the spread of cholera into new areas.3 Some roadways were also damaged or cut off from the eruption, affecting humanitarian operations and raising concerns of higher food prices and transport costs. Recent estimates indicate at least 32 people died directly from the eruption-- with 3,629 houses burned and seven schools destroyed from the lava flows.4 In total, the May 27 evacuation of ten neighborhoods of the city of Goma led to the immediate displacement of more than 230,000 people.5 OCHA estimates indicated around 63,000 of these persons were displaced to Sake—and another 53,000 fled to Rwanda.6 An International Organization for Migration estimate put the total number of displaced from the eruption at more than 415,000 people.7 Returns Begin Amid Water, Cholera Concerns DRC Prime Minister Jean-Michel Sama Lukonde Kyenge -
Ebola in the DRC: Report September 2020
The Congo Research Group (CRG) is an independent, non-profit research project dedicated to understanding the violence that affects millions of Congolese. We carry out rigorous research on different aspects of the conflict in the Democratic Republic of the Congo. All of our research is informed by deep historical and social knowledge of the problem at hand. We are based at the Center on International Cooperation at New York University. All of our publications, blogs and podcasts are available at: www.congoresearchgroup.org and www.gecongo.org This report was made possible thanks to funding from the European Union through its Instrument contributing to Stability and Peace. Cover photo: 17 January 2019, Beni, North Kivu region, Democratic Republic of Congo. A doctor talks with Julie, in her cube at the Ebola Treatment Center. Photo: World Bank / Vincent Tremeau Ebola in the DRC: Report September 2020 Table of Contents Executive Summary ...................................................................................................................................... 4 Introduction ................................................................................................................................................. 5 Ebola: From Neglected Tropical Disease to Global Health Security Threat ....................................................... 7 Medicine in DRC: From Colonial Tool to Site of Extraction .............................................................................. 8 The Building of a Parallel Health System .....................................................................................................11 -
Democratic Republic of Congo • North Kivu Situation Report No
Democratic Republic of Congo • North Kivu Situation Report No. 4 03 August 2012 This report is produced by OCHA in collaboration with humanitarian partners. It was issued by OCHA DRC. It covers the period from 28 July to 03 August 2012. The next report will be issued on or around 10 August. I. HIGHLIGHTS/KEY PR IORITIES • The CERF allocates US$9.9 million to boost humanitarian response to North Kivu crisis. • Around 30,000 IDPs reported to have fled the Kibati area due to FARDC-M23 fighting. • Priority needs in IDP settlements and camps around Goma include access to health care and potable water. II. Situation Overview Since 26 July no clashes have been reported between the RDC - Nord Kivu Armed Forces of the Democratic Republic of the Congo (FARDC) and the M23 in Rutshuru Territory. On 31 July, Orientale the armed group Patriotic Alliance for a Free and Sovereign Congo (APCLS) launched an attack on the Beni FARDC, taking over the city of Kashuga in Masisi Territory. Civilians fled to Mweso and Kitchanga when the fighting Lubero OUGANDA started. On the first of August, the FARDC retook the city. REPUBLIQUE DEMOCRATIQUE Nord Kivu Pendular population movements have also been reported DU CONGO towards Mweso, Busamba, Mpati, Kitchanga and Kanyabayonga elsewhere as a result of a looting spree by armed groups Rutshuru Karambi of 10 villages located north and south-west of Kitchanga. Walikale Kitchanga Rubare Bunagana On 3 August, an armed group attacked the FARDC in Ntamugenga Masisi Nyiragongo Kasindi in Beni Territory. Maniema Goma RWANDA Concerns have been raised in the north-east of Rutshuru Sud Kivu territory over reports of alliances and increased presence 100 Km of the armed group Democratic Forces for the Liberation Sources: ESRI, Europa Technologies, UNCS, RGC, OCHA et partenaires. -
Conflicts Around Virunga National Park: Grassroots Perspectives
Conflicts around Virunga National Park: Grassroots perspectives Acknowledgement This report would not have been possible without the support of the Knowledge Management Fund of the Knowledge Platform Security & Rule of Law. Esther Marijnen would also like to acknowledge the Centre for Public Authority and International Development (CPAID) at the London School of Economics and Political Science for its support (under grant nr ES/P008038/1). Suggested citation Verweijen, J., Kubuya, S., Mahamba, E., Marijnen, E., Murairi, J., and Mvano, C. (2020) “Conflicts around Virunga National Park: Grassroots perspectives”. The Hague: Knowledge Platform Security & Rule of Law. ◼ Conflicts around Virunga National Park: Grassroots 6 May 2020 Knowledge Platform Security & Rule of Law P 3 perspectives Table of contents Executive summary 4 Introduction 8 Methods 10 I. Conflicts around the park’s boundaries and resources 13 Boundary disputes 13 Contested access to natural resources 16 Human-wildlife conflict 19 II. Perspectives on park guard-population interactions 21 Experiences of the park’s law enforcement approach 21 Views on park guard behavior towards civilians 25 Human rights abuses and accountability 27 Perceptions of park guards’ training and discourses of civilians 31 Female park guards: improving community relations? 34 III.Perceptions of community engagement, decision-making and development projects37 Communication around the park’s management structures 38 Perceptions of participation in decision-making 41 Development projects: the Virunga Alliance and its perceived impacts 43 Conclusion and recommendations 46 Glossary of acronyms and words 51 Bibliography 54 Author bios 56 Annex I 57 Annex II 57 Annex III 61 ◼ Conflicts around Virunga National Park: Grassroots 6 May 2020 Knowledge Platform Security & Rule of Law P 4 perspectives Executive Summary Virunga National Park, a UNESCO world heritage site in eastern Democratic Republic of the Congo, is beset by conflicts. -
Mapping the Risk and Distribution of Epidemics in the WHO African Region
Mapping the Risk and Distribution of Epidemics in the WHO African Region A Technical Report May 2016 WHO/AFRO Library Cataloguing – in – Publication Data Mapping the Risk and Distribution of Epidemics in the WHO African Region: a technical report 1. Disease Outbreaks – statistics and numerical data 2. Epidemics – statistics and numerical data 3. Communicable Diseases – statistics and numerical data 4. Risk Assessment – supply and distribution – statistics and numerical data 5. Data collection – utilization 6. Africa I. Work Health Organization. Regional Office for Africa II. Title ISBN: 978-9290233084-4 (NLM Classification : WA 105) © WHO Regional Office for Africa, 2016 Publications of the World Health Organization enjoy copyright protection in accordance with the provisions of Protocol 2 of the Universal Copyright Convention. All rights reserved. Copies of this publication may be obtained from the Library, WHO Regional Office for Africa, P.O. Box 6, Brazzaville, Republic of Congo (Tel: +47 241 39100; Fax: +47 241 39507; E-mail: [email protected]). Requests for permission to reproduce or translate this publication – whether for sale or for non-commercial distribution – should be sent to the same address. The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate border lines for which there may not yet be full agreement. The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. -
Interim Report Government of Japan COUNTERING EPIDEMIC-PRONE
Government of Japan COUNTERING EPIDEMIC-PRONE DISEASES ALONG BORDERS AND MIGRATION ROUTE IN GUINEA Interim Report Project Period: 30 March 2016 – 29 March 2017 Reporting Period: 30 March 2016-31 August 2016 Funds: 2.000.000 USD Executing Organization: International Organization for Migration (IOM) Guinea October 2016 Interim Report to Government of Japan COUNTERING EPIDEMIC-PRONE DISEASES ALONG BORDERS AND MIGRATION ROUTES IN GUINEA Project Data Table Executing Organization: International Organization for Migration (IOM) Project Identification and IOM Project Code: MP.0281 Contract Numbers: Contract number: NI/IOM/120 Project Management Site Management Site: Conakry, CO, GUINEA and Relevant Regional Regional Office: Dakar, RO, SENEGAL Office: Project Period: 30 March 2016 – 29 March 2017 Geographical Coverage: Guinea Communal / Sub Prefectural / Prefectural / Regional Health authorities and Project Beneficiaries: Community members in Guinea Ministry of Health, National Health Security Agency, US Agency for international development (USAID), U.S. Office of Foreign Disaster Assistance Project Partner(s): (OFDA), Centre for Disease Control and Prevention (CDC), World Health Organization (WHO), International Medical Corps (IMC), Research triangle institute (RTI), Premieres Urgences (PU) Reporting Period: 30 March 2016 – 31 August 2017 Date of Submission: 30 October 2016 Total Confirmed 2,000,000 USD Funding: Total Funds Received to 2,000,000 USD Date: Total Expenditures: 439,761 USD Headquarters 17 route des Morillons • C.P. 71 • CH-1211 -
Key Considerations: 2021 Outbreak of Ebola in Guinea, the Context of N’Zérékoré
KEY CONSIDERATIONS: 2021 OUTBREAK OF EBOLA IN GUINEA, THE CONTEXT OF N’ZÉRÉKORÉ This brief summarises key considerations about the social, political and economic context shaping the outbreak of Ebola in the N’Zérékoré prefecture, Guinea, as of March 2021. The outbreak was declared on 14 February 2021, two weeks after the death of the first known case, a health agent (Agent Technique de Santé) from Gouécké. Gouécké is located 40km north of N’Zérékoré via the paved Route Nationale 2. The nurse sought care at a health centre in Gouécké, a clinic and then a traditional healer in N’Zérékoré. She died in N’Zérékoré on 28 January.1 When they became sick, the relatives of the first known case referred themselves to N’Zérékoré regional hospital, where the disease was transmitted to healthcare workers. Although the potential for transmission in rural areas of the Gouécké subprefecture was high, to date, most cases have been reported in the urban setting of N’Zérékoré, which is the focus of this brief. At the time of writing (22 March), the total number of cases was 18 (14 confirmed, four probable), with nine deaths and six recoveries. The last new case was reported on 4 March. N’Zérékoré city is the administrative capital of N’Zérékoré prefecture and N’Zérékoré region, and the largest urban centre of the Guinée Forestière area of south-east Guinea. It has an estimated population of 250,000, and is an important commercial, economic and transportation hub connecting Guinée Forestière to neighbouring Sierra Leone, Liberia and Côte d’Ivoire. -
Democratic Republic of the Congo
OPERATIONAL UPDATE Democratic Republic of the Congo 1 - 30 Septembre 2018 The security situation and human New arrivals of South 24,371 refugees at Lusenda site rights environment in Beni Sudanese refugees are creating received biomass briquettes; the Territory, North Kivu Province, growing shelter and space needs. first distribution of this scale for significantly deteriorated. UNHCR is The capacity of Meri settlement is Burundian refugees in South Kivu trying to ensure continuous of 20,000 people, but 33,517 Province. Biomass briquettes presence in Beni through missions refugees currently reside there. provide an environmentally-friendly from Goma and other offices. solution for cooking. Refugees Burundian refugees Total in the DRC Difference from previous month Repatriated this month 47,023 +511 10 As of 30 September 2018 ■ As of the end of September, 310 refugees at Lusenda site were registered as candidates for voluntary repatriation. On 18 September, 10 voluntarily returned to Burundi from Uvira, South Kivu Province. UNHCR provided transport and repatriation kits. 3 non-registered family members were also transported. ■ Between 31 August and 7 September, 305 refugees at Mulongwe settlement received cash transfers through mobile money. US$21,178 was transferred to cover school fees for the third trimester and construction costs for shelters, showers and latrines. ■ UNHCR relocated 1,232 Burundian refugees from transit centres to Mulongwe settlement between 1 and 17 September. Upon arrival, they were given non-food item (NFI) kits, and were temporarily hosted in common dormitories. They will be allocated plots of land and given cash and shelter kits. The relocation, which had been on hold due to funding constraints, eased the situation in overcrowded transit centres.