O True Apothecary: How Forensic Science Helps Solve a Classic Crime
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Nightshade”—A Hierarchical Classification Approach to T Identification of Hallucinogenic Solanaceae Spp
Talanta 204 (2019) 739–746 Contents lists available at ScienceDirect Talanta journal homepage: www.elsevier.com/locate/talanta Call it a “nightshade”—A hierarchical classification approach to T identification of hallucinogenic Solanaceae spp. using DART-HRMS-derived chemical signatures ∗ Samira Beyramysoltan, Nana-Hawwa Abdul-Rahman, Rabi A. Musah Department of Chemistry, State University of New York at Albany, 1400 Washington Ave, Albany, NY, 12222, USA ARTICLE INFO ABSTRACT Keywords: Plants that produce atropine and scopolamine fall under several genera within the nightshade family. Both Hierarchical classification atropine and scopolamine are used clinically, but they are also important in a forensics context because they are Psychoactive plants abused recreationally for their psychoactive properties. The accurate species attribution of these plants, which Seed species identifiction are related taxonomically, and which all contain the same characteristic biomarkers, is a challenging problem in Metabolome profiling both forensics and horticulture, as the plants are not only mind-altering, but are also important in landscaping as Direct analysis in real time-mass spectrometry ornamentals. Ambient ionization mass spectrometry in combination with a hierarchical classification workflow Chemometrics is shown to enable species identification of these plants. The hierarchical classification simplifies the classifi- cation problem to primarily consider the subset of models that account for the hierarchy taxonomy, instead of having it be based on discrimination between species using a single flat classification model. Accordingly, the seeds of 24 nightshade plant species spanning 5 genera (i.e. Atropa, Brugmansia, Datura, Hyocyamus and Mandragora), were analyzed by direct analysis in real time-high resolution mass spectrometry (DART-HRMS) with minimal sample preparation required. -
The Mandrake and the Ancient World,” the Evangelical Quarterly 28.2 (1956): 87-92
R.K. Harrison, “The Mandrake And The Ancient World,” The Evangelical Quarterly 28.2 (1956): 87-92. The Mandrake and the Ancient World R.K. Harrison [p.87] Professor Harrison, of the Department of Old Testament in Huron College, University of Western Ontario, has already shown by articles in THE EVANGELICAL QUARTERLY his interest and competence in the natural history of the Bible. Here he examines one of the more curious Biblical plants. The mandrake is one of the plants which still grows widely in the Middle East, and which has claimed magical associations from a very remote period. It is generally assigned the botanical name of Mandragora officinarum L..1 and is a perennial of the order Solanaceae. It claims affinity with the potato and eggplant, and is closely allied to the Atropa belladonna L.,2 with which it is not infrequently confused by some writers. The modern Arab knows it by a number of names, including Tuffah£ el Majanin (‘Madmen’s Apple) and Beid el Jinn (Eggs of the Jinn), apparently a reference to the ability of the plant to invigorate and stimulate the senses even to the point of mental imbalance. The former name may perhaps be a survival of the belief found in Oriental folk-lore regarding the magical herb Baaras, with which the mandrake is identified by some authorities.3 According to the legends associated with this plant, it was highly esteemed amongst the ancients on account of its pronounced magical properties. But because of the potency of these attributes it was an extremely hazardous undertaking for anyone to gather the plant, and many who attempted it were supposed to have paid for their daring with [p.88] sickness and death.4 Once the herb had been gathered, however, it availed for a number of diseases, and in antiquity it was most reputed for its ability to cure depression and general disorders of the mind. -
Drugs That Can Cause Delirium (Anticholinergic / Toxic Metabolites)
Drugs that can Cause Delirium (anticholinergic / toxic metabolites) Deliriants (drugs causing delirium) Prescription drugs . Central acting agents – Sedative hypnotics (e.g., benzodiazepines) – Anticonvulsants (e.g., barbiturates) – Antiparkinsonian agents (e.g., benztropine, trihexyphenidyl) . Analgesics – Narcotics (NB. meperidine*) – Non-steroidal anti-inflammatory drugs* . Antihistamines (first generation, e.g., hydroxyzine) . Gastrointestinal agents – Antispasmodics – H2-blockers* . Antinauseants – Scopolamine – Dimenhydrinate . Antibiotics – Fluoroquinolones* . Psychotropic medications – Tricyclic antidepressants – Lithium* . Cardiac medications – Antiarrhythmics – Digitalis* – Antihypertensives (b-blockers, methyldopa) . Miscellaneous – Skeletal muscle relaxants – Steroids Over the counter medications and complementary/alternative medications . Antihistamines (NB. first generation) – diphenhydramine, chlorpheniramine). Antinauseants – dimenhydrinate, scopolamine . Liquid medications containing alcohol . Mandrake . Henbane . Jimson weed . Atropa belladonna extract * Requires adjustment in renal impairment. From: K Alagiakrishnan, C A Wiens. (2004). An approach to drug induced delirium in the elderly. Postgrad Med J, 80, 388–393. Delirium in the Older Person: A Medical Emergency. Island Health www.viha.ca/mhas/resources/delirium/ Drugs that can cause delirium. Reviewed: 8-2014 Some commonly used medications with moderate to high anticholinergic properties and alternative suggestions Type of medication Alternatives with less deliriogenic -
Abortion in the Early Medieval West, C.500-900
„Alienated from the womb‟: abortion in the early medieval West, c.500-900 Zubin Mistry University College, London PhD Thesis 2011 1 I, Zubin Mistry, confirm that the work presented in this thesis is my own. Where information has been derived from other sources, I confirm that this has been indicated in the thesis. Signed: 2 ABSTRACT This thesis is primarily a cultural history of abortion in the early medieval West. It is a historical study of perceptions, rather than the practice, of abortion. The span covered ranges from the sixth century, when certain localised ecclesiastical initiatives in the form of councils and sermons addressed abortion, through to the ninth century, when some of these initiatives were integrated into pastoral texts produced in altogether different locales. The thesis uses a range of predominantly ecclesiastical texts – canonical collections, penitentials, sermons, hagiography, scriptural commentaries, but also law- codes – to bring to light the multiple ways in which abortion was construed, experienced and responded to as a moral and social problem. Although there is a concerted focus upon the ecclesiastical tradition on abortion, a focus which ultimately questions how such a tradition ought to be understood, the thesis also explores the broader cultural significance of abortion. Early medieval churchmen, rulers, and jurists saw multiple things in abortion and there were multiple perspectives upon abortion. The thesis illuminates the manifold and, occasionally, surprising ways in which abortion was perceived in relation to gender, sexuality, politics, theology and the church. The history of early medieval abortion has been largely underwritten. Moreover, it has been inadequately historicised. -
Read an Excerpt
WHAT'S PAST IS PROLOGUE ________________________________ A one-act comedy by David J. LeMaster This script is for evaluation only. It may not be printed, photocopied or distributed digitally under any circumstances. Possession of this file does not grant the right to perform this play or any portion of it, or to use it for classroom study. www.youthplays.com [email protected] 426-703-5315 What's Past is Prologue © David J. LeMaster All rights reserved. ISBN 978-1-62088-617-5. Caution: This play is fully protected under the copyright laws of the United States of America, Canada, the British Commonwealth and all other countries of the copyright union and is subject to royalty for all performances including but not limited to professional, amateur, charity and classroom whether admission is charged or presented free of charge. Reservation of Rights: This play is the property of the author and all rights for its use are strictly reserved and must be licensed by the author's representative, YouthPLAYS. This prohibition of unauthorized professional and amateur stage presentations extends also to motion pictures, recitation, lecturing, public reading, radio broadcasting, television, video and the rights of adaptation or translation into non-English languages. Performance Licensing and Royalty Payments: Amateur and stock performance rights are administered exclusively by YouthPLAYS. No amateur, stock or educational theatre groups or individuals may perform this play without securing authorization and royalty arrangements in advance from YouthPLAYS. Required royalty fees for performing this play are available online at www.YouthPLAYS.com. Royalty fees are subject to change without notice. -
PSYCHEDELIC DRUGS (P.L) 1. Terminology “Hallucinogens
PSYCHEDELIC DRUGS (p.l) 1. Terminology “hallucinogens” – induce hallucinations, although sensory distortions are more common “psychotomimetics” – to minic psychotic states, although truly most drugs in this class do not do so “phantasticums”or “psychedelics” – alter sensory perception (Julien uses “psychedelics”) alterations in perception, cognition, and mood, in presence of otherwise clear ability to sense” may increase sensory awareness, increase clarity, decrease control over what is sensed/experienced “self-A” may feel a passive observer of what “self-B” is experiencing often accompanied by a sense of profound meaningfulness, of divine or cosmic importance (limbic system?) these drugs can be classified by what NT they mimic: anti-ACh, agonists for NE, 5HT, or glutamate (See p. 332, Table 12.l in Julien, 9th Ed.) 2. The Anti-ACh Psychedelics e.g. scopolamine (classified as an ACh blocker) high affinity, no efficacy plant product: Belladonna or “deadly nightshade” (Atropa belladonna) Datura stramonium (jimson weed, stinkweed) Mandragora officinarum (mandrake plant) pupillary dilation (2nd to atropine) PSYCHEDELIC DRUGS (p.2) 2. Anti-ACh Psychedelics (cont.) pharmacological effects: e.g. scopolamine (Donnatal) clinically used to tx motion sickness, relax smooth muscles (gastric cramping), mild sedation/anesthetic effect PNS effects --- dry mouth relaxation of smooth muscles decreased sweating increased body temperature blurred vision dry skin pupillary dilation tachycardia, increased BP CNS effects --- drowsiness, mild euphoria profound amnesia fatigue decreased attention, focus delirium, mental confusion decreased REM sleep no increase in sensory awareness as dose increases --- restlessness, excitement, hallucinations, euphoria, disorientation at toxic dose levels --- “psychotic delirium”, confusion, stupor, coma, respiratory depression so drug is really an intoxicant, amnestic, and deliriant 3. -
Magical Herbalism Pdf, Epub, Ebook
MAGICAL HERBALISM PDF, EPUB, EBOOK Scott Cunningham | 260 pages | 08 Nov 2001 | Llewellyn Publications,U.S. | 9780875421209 | English | Minnesota, United States Magical Herbalism PDF Book Tend and care of the foxglove, also known as fairies thimbles, to enjoy their protection. Worn or carried, it ensures safety during travel. So, use aconite to wash your ritual tools and space. Nov 19, Natural magic utilizes the world around us for magical purposes. And most importantly, they work! This protection herb can be used in a sachet. Money, luck, healing, obtaining the treasure. Taken to funerals, eases grief and calms mind. Today the name Cunningham is synonymous with natural magic and the magical community. This is a popular Hoodoo charm for gamblers. Use to dress candles for any form of magickal healing. I'm an open-minded person, but I'm logical. Why are herbs magical? Smolder for purification. Any object which holds some caraway seeds is theft-free. Often used as a substitute for the rare mandrake root in poppet magick. Empower with tourmaline. Increases the power of any incense you make. A composition book or spiral bound notebook works perfectly! Magical Herbalism Writer Amaranth Amaranthus hydrochondriacus Love-lies-bleeding, red cockscomb, velvet flower Feminine. Out-of-Body Experiences. The question to ask is, How? Folk magick is accessible to everyone. A bag of camphor hung around the neck keeps flus and colds away. Use with caution. Burn as incense or carry as a sachet for a good psychic power stimulator. Bavarian Root Doctors and Herbal Lore. Corn Zea Mays aka maize, seed of seeds, sacred mother Feminine. -
The Prisoner's Apothecary
Oct. 30 - Nov. 6, 2019 www.lansingcitypulse.com Locally owned • A newspaper for the rest of us The Prisoner’s Apothecary Visiting MSU artist plants seeds to a revolution See page 15 2 www.lansingcitypulse.com City Pulse • October 30, 2019 Thanksgiving Fresh includes materials, snacks & refreshments Cut Flower $ Call the Floral Shop Centerpiece Class 45 517-372-5610 to reserve your spot City Pulse • October 30, 2019 www.lansingcitypulse.com 3 Favorite Tings Kewpee’s owner Autumn Weston and her Kewpie doll BWL Seeks Public Input on Future Energy Plan for Region The BWL will host open houses to seek public input as we update our plan to continue delivering cleaner, affordable and reliable power to the region. Join us at one of the dates below to learn about the BWL’s new Integrated Resource Plan People really don’t know how to that’s been part of us since we started (IRP), which will serve as the foundation for our take the baby. People don’t even know in 1923. I’m a fourth-generation own- what to call our mascot. Some know er and we always got Kewpie dolls for new strategic plan. what a Kewpie doll is, but most just our birthdays. I always thought “Can’t call it the “creepy baby.” Even I’m I get a Cabbage Patch doll or Barbie Wednesday, Nov. 6, 4:30-7pm guilty of that. I’ve got two tattoos of or something? This baby doesn’t even BWL REO Depot, 1201 S. Washington Ave., Lansing them so I don’t think they are that have clothes to play with.” creepy. -
Herbal Abortifacients and Their Classical Heritage in Tudor England
Penn History Review Volume 20 Issue 1 Spring 2013 Article 3 December 2013 Herbal Abortifacients and their Classical Heritage in Tudor England Alex Gradwohl University of Pennsylvania, [email protected] Follow this and additional works at: https://repository.upenn.edu/phr Recommended Citation Gradwohl, Alex (2013) "Herbal Abortifacients and their Classical Heritage in Tudor England," Penn History Review: Vol. 20 : Iss. 1 , Article 3. Available at: https://repository.upenn.edu/phr/vol20/iss1/3 This paper is posted at ScholarlyCommons. https://repository.upenn.edu/phr/vol20/iss1/3 For more information, please contact [email protected]. Herbal Abortifacients H#%1.0 A1'%$+&.2+#-$, .-* $)#+% C0.,,+2.0 H#%+$.3# +- T4*'% E-30.-*: Alex Gradwohl Although birth control is often considered to be a modern innovation, various forms of homeopathic anti-fertility measures have been in use since ancient times. Discussed at length by the great Greco-Roman medical authorities, certain herbs have long been utilized for their abortion-inducing properties. Centuries later, the extensive herbal guides and other medical texts of Tudor England seem to largely ignore the subject of anti-fertility herbs. Despite this apparent silence, however, classical knowledge of herbal abortifacients did not GLVDSSHDULQVL[WHHQWKFHQWXU\(QJODQG,QÁXHQFHGE\FKDQJLQJ attitudes and social acceptability concerning abortion, English medical and herbal writers included disguised information about certain herbs’ potential abortive uses, providing Tudor women with an important means to control their fertility.1 It is easy to overlook the inclusion of abortifacients when examining Tudor medical and herbal sources since they generally do not overtly reference or explain the uses of these herbs. -
HANDBOOK of Medicinal Herbs SECOND EDITION
HANDBOOK OF Medicinal Herbs SECOND EDITION 1284_frame_FM Page 2 Thursday, May 23, 2002 10:53 AM HANDBOOK OF Medicinal Herbs SECOND EDITION James A. Duke with Mary Jo Bogenschutz-Godwin Judi duCellier Peggy-Ann K. Duke CRC PRESS Boca Raton London New York Washington, D.C. Peggy-Ann K. Duke has the copyright to all black and white line and color illustrations. The author would like to express thanks to Nature’s Herbs for the color slides presented in the book. Library of Congress Cataloging-in-Publication Data Duke, James A., 1929- Handbook of medicinal herbs / James A. Duke, with Mary Jo Bogenschutz-Godwin, Judi duCellier, Peggy-Ann K. Duke.-- 2nd ed. p. cm. Previously published: CRC handbook of medicinal herbs. Includes bibliographical references and index. ISBN 0-8493-1284-1 (alk. paper) 1. Medicinal plants. 2. Herbs. 3. Herbals. 4. Traditional medicine. 5. Material medica, Vegetable. I. Duke, James A., 1929- CRC handbook of medicinal herbs. II. Title. [DNLM: 1. Medicine, Herbal. 2. Plants, Medicinal.] QK99.A1 D83 2002 615′.321--dc21 2002017548 This book contains information obtained from authentic and highly regarded sources. Reprinted material is quoted with permission, and sources are indicated. A wide variety of references are listed. Reasonable efforts have been made to publish reliable data and information, but the author and the publisher cannot assume responsibility for the validity of all materials or for the consequences of their use. Neither this book nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, microfilming, and recording, or by any information storage or retrieval system, without prior permission in writing from the publisher. -
The Worshipful Society of Apothecaries of London P Hunting
41 Postgrad Med J: first published as 10.1136/pmj.2003.015933 on 3 February 2004. Downloaded from HISTORY OF MEDICINE The Worshipful Society of Apothecaries of London P Hunting ............................................................................................................................... Postgrad Med J 2004;80:41–44. doi: 10.1136/pgmj.2003.015933 The Society of Apothecaries is both a City livery company chose to practise as an apothecary from a shop at Black Friars, making his name and fortune from and an examining authority for the medical profession. the manufacture of De Laune’s Pills, a nostrum Founded in 1617 by the royal apothecary Gideon de recommended for scurvy, dropsy, jaundice, Laune leading a breakaway group from the Grocers’ venereal disease, worms, etc. De Laune did not join the Grocers’ Company and he was prepared Company, the Society was instrumental in raising the status to defy that Company’s authority by leading a of apothecaries as general practitioners. Under the breakaway group of apothecaries determined to Apothecaries’ Act (1815) the Society examined for the LSA establish their independence. There was an acrimonious confrontation between de Laune and it now awards the LMSSA (Licence in Medicine and and the Court of the Grocers’ Company in 1610 Surgery of the Society of Apothecaries) and postgraduate when the apothecaries’ bid for self regulation diplomas, while maintaining the civic, charitable, and failed. By 1614 however, de Laune had recruited the support of a fellow Huguenot, the King’s ceremonial traditions of a livery company of the City of physician Dr Theodore Mayerne, and Dr Henry London. Atkins, seven times President of the College of .......................................................................... -
Genus Mandragora (Solanaceae)
Bull. not. Hist. Mus. Land. (Bot.) 28(1): 17^0 Issued 25 June 1998 A revision of the genus Mandragora (Solanaceae) STEFAN UNGRICHT* SANDRA KNAPP AND JOHN R. PRESS Department of Botany, Tne~Natural History Museum, Cromwell Road, London SW7 5BD * Present address: Waldmatt 6, CH-5242 Birr, Switzerland CONTENTS Introduction 17 Mythological and medicinal history 18 Taxonomic history 18 Materials and methods 19 Material examined 19 Taxonomic concepts 20 Morphometrics 21 Cladistics 22 Results and discussion 22 Species delimitations using morphometric analyses 22 Phylogeny 26 Biogeography 26 Taxonomic treatment 29 Mandragora L 29 Key to the species of Mandragora 30 1. Mandragora officinarum L 30 2. Mandragora turcomanica Mizg 33 3. Mandragora caulescens C.B. Clarke 34 References 36 Exsiccatae 38 Taxonomic index ... 40 SYNOPSIS. The Old World genus Mandragora L. (Solanaceae) is revised for the first time across its entire geographical range. The introduction reviews the extensive mythological and medicinal as well as the taxonomic history of the genus. On morphological and phenological grounds three geographically widely disjunct species can be distinguished: the Mediterranean M. officinarum L., the narrowly local Turkmenian endemic M. turcomanica Mizg. and the Sino-Himalayan M caulescens C.B. Clarke. The generic monophyly of Mandragora L. as traditionally circumscribed is supported by cladistic analysis of morphological data. The ecological and historical phytogeography of the genus is discussed and alternative biogeographical scenarios are evaluated. Finally, a concise taxonomic treatment of the taxa is provided, based on the evidence of the preceeding analyses. INTRODUCTION The long history of mythology and medicinal use of the mandrake combined with the variable morphology and phenology have led to The nightshade family (Solanaceae) is a cosmopolitan but predomi- considerable confusion in the classification of Mandragora.