DOCSLIB.ORG

CSHL AR 1997.Pdf

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text

Load more

ANNUAt REPORT 1997COLD SPRING HARBOR LABORATORY ANNUAL REPORT 1997 ©1998 by Cold Spring Harbor Laboratory Cold Spring Harbor Laboratory P.O. Box 100 1 Bungtown Road Cold Spring Harbor, New York 11724 Website: http://www.cshl.org Managing Editor Wendy Goldstein Editorial staff Dorothy Brown Nonscientific Photography Margot Bennett, Ed Campodonico, Bill Dickerson, Mar *la Emmons Typography Elaine Gaveglia Cover design Tony Urgo Book design Emily Harste Front cover: Hippocampal pyramidal neurons in a living brain slice infected with a GFP-expressing virus imaged with two-pho- ton laser scanning microscopy. Individual spines, the post-synap- tic parts of synapses, can be clearly seen. (Mirjana Maletic- Zavati, Roberto Malinow, Karel Svoboda) Back cover: Richards Building Section title pages: Marlena Emmons, Ed Campodonico Contents Officers of the Corporation/Board of Trustees v Governance and Major Affiliations vi Committees vii Alfred Day Hershey (1908-1997) viii PRESIDENT'S ESSAY Remembering Manny Delbriick (1917-1998)8 DIRECTOR'S REPORT 10 Highlights14 ADMINISTRATION REPORT 41 RESEARCH 47 Tumor Viruses 48 Molecular Genetics 75 Cell Biology 107 Structure and Genomics 139 Neuroscience 163 Author Index 191 COLD SPRING HARBOR MEETINGS AND COURSES 193 Academic Affairs 194 Symposium on Quantitative Biology196 Meetings 199 Postgraduate Courses 223 Seminars 263 Undergraduate Research 265 Nature Study267 BANBURY CENTER 269 Director's Report 270 Meetings 276 DNA LEARNING CENTER 301 Director's Report303 Workshops, Meetings, and Collaborations317 COLD SPRING HARBOR LABORATORY PRESS 321 Publications 322 Executive Director's Report 323 FINANCE 329 Financial Statements 330 Financial Support334 Grants 334 Methods of Contributing 342 Capital and Program Contributions 343 Child Care Center Capital Campaign 344 Annual Contributions 345 LABORATORY STAFF 355 iii Standing (from left):E.S. Marks, M.F. Gerry, T.A. Saunders Ill, M. Ptashne, J.A. Steitz, J.R. Reeves, G.R. Fink, C.T. Caskey, L.N. Grace, J.J. Phelan, Jr., W.S. Robertson, B. Stillman, L.B. Polsky, G. Globel, M.D. Lindsay, J.P. Cleary Sitting (from left): T.J. Knight, D.L. Luke III, W.V.P. Russell, J.D. Watson, W. Pidot Not shown: E.E. Harlow, J. Kuriyan, A.J. Levine, L. Mendell, J.A. Movshon, H. Dolan, D.H. Koch, W.L. Matheson, W.R. Miller, W.E. Murray, J.R. Reese Officers of the Corporation David L. Luke III, Chairman James D. Watson, Ph.D., President William R. Miller, Vice Chairman Bruce Stillman, Ph.D., Director Thomas A. Saunders Ill, Vice Chairman G. Morgan Browne, Administrative Director John R. Reese, Treasurer Martha Farish Gerry, Secretary Board of Trustees Scientific Trustees Edward E. Harlow, Ph.D. Helen Dolan John R. Reese Massachusetts General Hospital Oyster Bay, New York Cold Spring Harbor, New York John Kuriyan, Ph.D. Martha Farish Gerry William S. Robertson Howard Hughes Medical Institute Mill Neck, New York Huntington, New York Rockefeller University Lola N. Grace Thomas A. Saunders III Arnold J. Levine, Ph.D. Oyster Bay Cove, New York Locust Valley, New York Princeton University David H. Koch James D. Watson, Ph.D Lorne Mendell, Ph.D. New York, New York Cold Spring Harbor, New York State University of New York, Stony Brook David L. Luke III Honorary Trustees New York, New York J. Anthony Movshon, Ph.D. Bayard Clarkson, M.D. Howard Hughes Medical Institute Edwin S. Marks Memorial Sloan-Kettering Cancer New York University Kings Point, New York Center, New York, New York Mark Ptashne, Ph.D. William L. Matheson Robert Cummings Memorial Sloan-Kettering Cancer Mill Neck, New York Glen Head, New York Center William R. Miller H. Bentley Glass Joan A. Steitz, Ph.D. New York, New York Boulder, Colorado Yale University School of Medicine William E. Murray Townsend J. Knight Bruce Stillman, Ph.D. New York, New York New York, New York Cold Spring Harbor Laboratory John J. Phelan, Jr. Mary D. Lindsay Individual Trustees Mill Neck, New York New York, New York C. Thomas Caskey Whitney D. Pidot Walter H. Page West Point, Pennsylvania Locust Valley, New York Cold Spring Harbor, New York John P. Cleary, Esq. Leon B. Polsky Wendy VP. Russell Oyster Bay, New York New York, New York Oyster Bay, New York Governance and Major Affiliations The Laboratory is governed by a 30-member Board of Trustees which meets three or four times a year. Authority to act for the Board of Trustees between meetings is vested in the Executive Committee of the Board of Trustees. The Executive Committee is composed of the Officers of the Board plus any other members who may be elected to the Executive Committee by the Board of Trustees. Additional standing and ad hoc committees are appointed by the Board of Trustees to provide guidance and advice in specific areas of the Laboratory's operations. Representation on the Board of Trustees itself is divided between community representatives and scientists from major educational and research institutions. The Laboratory is chartered as an educational and research institution by the Board of Regents of the Education Department of the State of New York.It is designated as a "public charity" by the Internal Revenue Service. vi Committees Audit John P. Cleary, Esq. Thomas A. Saunders Ill Rick Cosnotti James D. Watson, Ph.D. Whitney D. Pidot, Chairman Martha F Gerry Lola N. Grace Lola N. Grace Ex Officio William L. Matheson Townsend J. Knight David L. Luke Ill John J. Phelan Lauri J. Landeau, V.M.D. Leon Polsky Carol Large Nominating Mary D. Lindsay Banbury Program David L. Luke Ill David L. Luke III, Chairman Wendy V.P. Russell William R. Miller Arnold Levine, Ph.D., Chairman James D. Watson, Ph.D. Whitney D. Pidot Martha F. Gerry John R. Reese John Kurian, Ph.D. Executive Committee Thomas A. Saunders Ill Anthony Movshon, Ph.D. James D. Watson, Ph.D. Jan A. Witkowski, Ph.D. David L. Luke III, Chairman G. Morgan Browne Robertson House Building John P. Cleary, Esq. Lola N. Grace William S. Robertson, Chairman Helen A. Dolan, Chairman Edwin S. Marks G. Morgan Browne Arthur Brings William R. Miller Jack Richards John P. Cleary, Esq. John J. Phelan Maude Robertson Martha F. Gerry Whitney D. Pidot Jan Witkowski, Ph.D. Mary D. Lindsay John R. Reese Jack Richards Thomas A. Saunders Ill Robertson Research Fund Wendy V.P. Russell Bruce Stillman, Ph.D. Elizabeth Watson James D. Watson, Ph.D. John R. Reese, Chairman Commercial Relations G. Morgan Browne Finance and Investment David L. Luke III John P. Phelan, Chairman Bruce Stillman, Ph.D. John R. Reese, Chairman G. Morgan Browne James D. Watson, Ph.D. G. Morgan Browne Winship Herr, Ph.D. Lola N. Grace David L. Luke Ill Family Representatives William D. Keen John P. Maroney David H. Koch William R. Miller Katherine Ernst, Chairman David L. Luke Ill Mark Ptashne, Ph.D. Walter Meier, M.D. Edwin S. Marks Bruce Stillman, Ph.D. William S. Robertson William R. Miller Carl Schafer William E. Murray Compensation Leon Polsky Tenure and Appointments William S. Robertson David L. Luke III, Chairman Thomas A. Saunders Ill William R. Miller Joan A. Steitz, Ph.D., Chairman Whitney D. Pidot C. Thomas Caskey, M.D. John R. Reese Long-range Planning Edward Harlow, Ph.D. Thomas A. Saunders Ill John Kuriyan, Ph.D. Bruce Stillman, Ph.D., Chairman Arnold Levine, Ph.D. Development Thomas Caskey, M.D. Lorne Mendell, Ph.D. Arnold Levine, Ph.D. J. Anthony Movshon, Ph.D. Thomas A. Saunders, Chairman William R. Miller Mark Ptashne, Ph.D. G. Morgan Browne Mark Ptashne, Ph.D. Bruce Stillman, Ph.D. vii Alfred Day Hershey (1908-1997) Most of the basic facts about the gene and how it functions were learned through studies of bacteriophages, the viruses of bacteria. Phages came into biological prominence through experiments done in wartime United States by the German physicist, Max DelbrOck, and the Italian biologist, Salvador Luria. They believed that in studying how a single phage particle multiplies within a host bacterium to form many identical progeny phages, they were in effect studying naked genes in action. Soon they recruited the American chemist-turned-biologist Alfred Hershey to their way of thinking, and in 1943 the "Phage Group" was born. Of this famous trio, who were to receive in 1969 the Nobel Prize, Hershey was initially the least celebrated. Al had no trace of DelbrOck's almost evangelical charisma or of Luria's candid assertiveness and never welcomed the need to travel and expose his ideas to a wide audience. He framed his experiments to convince him- self, not others, that he was on the right track. Then he could enjoy what he called Hershey Heaven, doing experiments that he understood would give the same answer upon repetition. Although both he and Luria had indepen- dently demonstrated that phages upon multiplying give rise to stable vari- ants (mutants), it was Hershey, then in St. Louis, who in 1948 showed that their genetic determinants (genes) were linearly linked to each other like the genes along chromosomes of higher organisms. His most famous experiment, however, occurred soon after he moved to the Department of Genetics of the Carnegie Institution of Washington in Cold Spring Harbor on Long Island. There, in 1952, with his assistant, Martha Chase, he showed that phage DNA, not its protein component, contains the phage genes. After a tadpole-shaped phage particle attaches to a bacteri- um, its DNA enters through a tiny hole while its protein coat remains outside. Key to Hershey's success was showing that viral infection is not affected by violent agitation in a kitchen blender, which removes the empty viral protein shells from the bacterial surface. Although there was already good evidence from the 1944 announcement of Avery, MacLeod, and McCarty at the Rockefeller Institute that DNA could genetically alter the surface properties of bacteria, its broader significance was unknown.
Recommended publications
  • Basso Et Al-2018-New Phytologi

    Basso Et Al-2018-New Phytologi

    Facing global change Veronica Basso, Maira de Freitas Pereira, François Maillard, Julieta Mallerman, Lauralie Mangeot-Peter, Feng Zhang, Clémence Bonnot To cite this version: Veronica Basso, Maira de Freitas Pereira, François Maillard, Julieta Mallerman, Lauralie Mangeot- Peter, et al.. Facing global change: The millennium challenge for plant scientists. New Phytologist, Wiley, 2018, 220 (1), pp.25-29. 10.1111/nph.15376. hal-01890694 HAL Id: hal-01890694 https://hal.archives-ouvertes.fr/hal-01890694 Submitted on 8 Oct 2018 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Distributed under a Creative Commons Attribution| 4.0 International License Forum Meetings National Laboratory, TN, USA) highlighted the critical topics Facing global change: the and knowledge gaps the scientific community needs to fill in order to harness plant sciences to solve these societal issues. This event, millennium challenge for plant held in Nancy, France on 11–13 April 2018, hosted researchers scientists from 70 universities, research institutes and companies represent- ing 29 countries in the fields of Developmental biology, Evolu- 41st New Phytologist Symposium ‘Plant sciences tionary biology, Ecology, Plant–microorganism interactions, Physiology and Genetic engineering (Fig. 1).
  • The Creation of Neuroscience

    The Creation of Neuroscience

    The Creation of Neuroscience The Society for Neuroscience and the Quest for Disciplinary Unity 1969-1995 Introduction rom the molecular biology of a single neuron to the breathtakingly complex circuitry of the entire human nervous system, our understanding of the brain and how it works has undergone radical F changes over the past century. These advances have brought us tantalizingly closer to genu- inely mechanistic and scientifically rigorous explanations of how the brain’s roughly 100 billion neurons, interacting through trillions of synaptic connections, function both as single units and as larger ensem- bles. The professional field of neuroscience, in keeping pace with these important scientific develop- ments, has dramatically reshaped the organization of biological sciences across the globe over the last 50 years. Much like physics during its dominant era in the 1950s and 1960s, neuroscience has become the leading scientific discipline with regard to funding, numbers of scientists, and numbers of trainees. Furthermore, neuroscience as fact, explanation, and myth has just as dramatically redrawn our cultural landscape and redefined how Western popular culture understands who we are as individuals. In the 1950s, especially in the United States, Freud and his successors stood at the center of all cultural expla- nations for psychological suffering. In the new millennium, we perceive such suffering as erupting no longer from a repressed unconscious but, instead, from a pathophysiology rooted in and caused by brain abnormalities and dysfunctions. Indeed, the normal as well as the pathological have become thoroughly neurobiological in the last several decades. In the process, entirely new vistas have opened up in fields ranging from neuroeconomics and neurophilosophy to consumer products, as exemplified by an entire line of soft drinks advertised as offering “neuro” benefits.
  • Meeting of Research and Clinical Leaders, Advocates and Patients to Highlight the Need to Reinstate Spinal Cord Injury Research Funding in Nys

    Meeting of Research and Clinical Leaders, Advocates and Patients to Highlight the Need to Reinstate Spinal Cord Injury Research Funding in Nys

    MEETING OF RESEARCH AND CLINICAL LEADERS, ADVOCATES AND PATIENTS TO HIGHLIGHT THE NEED TO REINSTATE SPINAL CORD INJURY RESEARCH FUNDING IN NYS NYS has a Unique Spinal Cord Injury Program (SCIRP) funded through a small surcharge on traffic ticket moving violations. Since 1998 SCIRP has provided 70 million dollars towards treatments for spinal cord injury. After 2010, this money raised for paralysis research has been diverted to other purposes. We come together to urge NYS to reinstate this essential funding stream. Location: Empire State Convention Center, Meeting Rooms 2 &3, S. Mall Arterial, Albany NY 12242 Time: 9am-5.30pm, INCLUDING PRESS CONFERENCE AT 1PM Registration Required: Email Event Coordinator Cindy Butler [email protected] call 518 694 8188 by February 11th Register Early, space limited. Wheelchair accessible. Lunch provided, donation for meeting, $40 suggested Directions and Parking: visit http://ogs.ny.gov/ESP/CCE PROGRAM 9.00-9.10am Welcome and Introduction- Raj Ratan, Burke Medical Research Institute 9.10-10.00am NYS Support of Spinal Cord Injury Research – Raj Ratan, Chair 9.10- Terry O’Neill, Constantine Institute– How SCIRP came to be 9.25- Lorne Mendell, Stony Brook University - Intro to SCI and The Success of SCIRP Investment 9.40- Raj Ratan, Burke Medical Research Institute - On the SCI Network 9.55-Questions – 5 mins 10.00-10.50am Neuroplasticity and Robotics for Functional Recovery–Jon Wolpaw, Chair – 10.00-Jon Wolpaw, Wadsworth Institute -H-Reflex Plasticity 10.15-Aiko Thompson, Helen Hayes Hospital- Using
  • Medical Advisory Board September 1, 2006–August 31, 2007

    Medical Advisory Board September 1, 2006–August 31, 2007

    hoWard hughes medical iNstitute 2007 annual report What’s Next h o W ard hughes medical i 4000 oNes Bridge road chevy chase, marylaNd 20815-6789 www.hhmi.org N stitute 2007 a nn ual report What’s Next Letter from the president 2 The primary purpose and objective of the conversation: wiLLiam r. Lummis 6 Howard Hughes Medical Institute shall be the promotion of human knowledge within the CREDITS thiNkiNg field of the basic sciences (principally the field of like medical research and education) and the a scieNtist 8 effective application thereof for the benefit of mankind. Page 1 Page 25 Page 43 Page 50 seeiNg Illustration by Riccardo Vecchio Südhof: Paul Fetters; Fuchs: Janelia Farm lab: © Photography Neurotoxin (Brunger & Chapman): Page 3 Matthew Septimus; SCNT images: by Brad Feinknopf; First level of Rongsheng Jin and Axel Brunger; iN Bruce Weller Blake Porch and Chris Vargas/HHMI lab building: © Photography by Shadlen: Paul Fetters; Mouse Page 6 Page 26 Brad Feinknopf (Tsai): Li-Huei Tsai; Zoghbi: Agapito NeW Illustration by Riccardo Vecchio Arabidopsis: Laboratory of Joanne Page 44 Sanchez/Baylor College 14 Page 8 Chory; Chory: Courtesy of Salk Janelia Farm guest housing: © Jeff Page 51 Ways Illustration by Riccardo Vecchio Institute Goldberg/Esto; Dudman: Matthew Szostak: Mark Wilson; Evans: Fred Page 10 Page 27 Septimus; Lee: Oliver Wien; Greaves/PR Newswire, © HHMI; Mello: Erika Larsen; Hannon: Zack Rosenthal: Paul Fetters; Students: Leonardo: Paul Fetters; Riddiford: Steitz: Harold Shapiro; Lefkowitz: capacity Seckler/AP, © HHMI; Lowe: Zack Paul Fetters; Map: Reprinted by Paul Fetters; Truman: Paul Fetters Stewart Waller/PR Newswire, Seckler/AP, © HHMI permission from Macmillan Page 46 © HHMI for Page 12 Publishers, Ltd.: Nature vol.
  • Barbara Mcclintock's World

    Barbara Mcclintock's World

    Barbara McClintock’s World Timeline adapted from Dolan DNA Learning Center exhibition 1902-1908 Barbara McClintock is born in Hartford, Connecticut, the third of four children of Sarah and Thomas Henry McClintock, a physician. She spends periods of her childhood in Massachusetts with her paternal aunt and uncle. Barbara at about age five. This prim and proper picture betrays the fact that she was, in fact, a self-reliant tomboy. Barbara’s individualism and self-sufficiency was apparent even in infancy. When Barbara was four months old, her parents changed her birth name, Eleanor, which they considered too delicate and feminine for such a rugged child. In grade school, Barbara persuaded her mother to have matching bloomers (shorts) made for her dresses – so she could more easily join her brother Tom in tree climbing, baseball, volleyball, My father tells me that at the and football. age of five I asked for a set of tools. He My mother used to did not get me the tools that you get for an adult; he put a pillow on the floor and give got me tools that would fit in my hands, and I didn’t me one toy and just leave me there. think they were adequate. Though I didn’t want to tell She said I didn’t cry, didn’t call for him that, they were not the tools I wanted. I wanted anything. real tools not tools for children. 1908-1918 McClintock’s family moves to Brooklyn in 1908, where she attends elementary and secondary school. In 1918, she graduates one semester early from Erasmus Hall High School in Brooklyn.
  • Genetics Society News

    Genetics Society News

    July 2008 . ISSUE 59 GENETICS SOCIETY NEWS www.genetics.org.uk IN THIS ISSUE Genetics Society News is edited by Steve Russell. Items for future issues should be sent to Steve Russell, preferably by email to • Genetics Society Epigenetics Meeting [email protected], or hard copy to Department of Genetics, • Genetics Society Sponsored Meetings University of Cambridge, Downing Street, Cambridge CB2 3EH. The Newsletter is published twice a year, with copy dates of 1st June and • Travel, Fieldwork and Studentship Reports 26th November. • John Evans: an Appreciation Cocoons of the parasitoid wasp Cotesia vestalis on cabbage leaf in Taiwan. From the • Twelve Galton Lectures fieldwork report by Jetske G. de Boer on page 36. • My Favourite Paper A WORD FROM THE EDITOR A word from the editor ow soon until the $1000 based on the results of tests we genome is actually with barely understand! Here in the Hus and individual UK there is currently a sequencing is widespread? The moratorium, adhered to by publication of increasing most insurers, on the use of numbers of individual human genetic testing information for genome sequences suggests assessing life insurance that we should start to consider applications. It is important some of the implications that this remains in place and associated with the availability its effectiveness is reviewed of personal genetic well before the current information. In this issue we moratorium expires in 2011. present two articles reflecting The Human Genetics on his issue: a report from a Commission Genetics Society sponsored (http://www.hgc.gov.uk) meeting recently held in monitor issues relating to Cambridge organised by The genetic discrimination in the Triple Helix, an international UK and are a point of contact undergraduate organisation, as for those with any concerns in the Millennium Technology Prize.
  • Moore Noller

    Moore Noller

    2002 Ada Doisy Lectures Ada Doisy Lecturers 2003 in BIOCHEMISTRY Sponsored by the Department of Biochemistry • University of Illinois at Urbana-Champaign Dr. Peter B. 1970-71 Charles Huggins* and Elwood V. Jensen A76 1972-73 Paul Berg* and Walter Gilbert* Moore 1973-74 Saul Roseman and Bruce Ames Department of Molecular carbonyl Biophysics & Biochemistry Phe 1974-75 Arthur Kornberg* and Osamu Hayaishi Yale University C75 1976-77 Luis F. Leloir* New Haven, Connecticutt 1977-78 Albert L. Lehninger and Efraim Racker 2' OH attacking 1978-79 Donald D. Brown and Herbert Boyer amino N3 Tyr 1979-80 Charles Yanofsky A76 4:00 p.m. A2486 1980-81 Leroy E. Hood Thursday, May 1, 2003 (2491) 1983-84 Joseph L. Goldstein* and Michael S. Brown* Medical Sciences Auditorium 1984-85 Joan Steitz and Phillip Sharp* Structure and Function in 1985-86 Stephen J. Benkovic and Jeremy R. Knowles the Large Ribosomal Subunit 1986-87 Tom Maniatis and Mark Ptashne 1988-89 J. Michael Bishop* and Harold E. Varmus* 1989-90 Kurt Wüthrich Dr. Harry F. 1990-91 Edmond H. Fischer* and Edwin G. Krebs* 1993-94 Bert W. O’Malley Noller 1994-95 Earl W. Davie and John W. Suttie Director, Center for Molecular Biology of RNA 1995-96 Richard J. Roberts* University of California, Santa Cruz 1996-97 Ronald M. Evans Santa Cruz, California 1998-99 Elizabeth H. Blackburn 1999-2000 Carl R. Woese and Norman R. Pace 2000-01 Willem P. C. Stemmer and Ronald W. Davis 2001-02 Janos K. Lanyi and Sir John E. Walker* 12:00 noon 2002-03 Peter B.
  • Barbara Mcclintock

    Barbara Mcclintock

    Barbara McClintock Lee B. Kass and Paul Chomet Abstract Barbara McClintock, pioneering plant geneticist and winner of the Nobel Prize in Physiology or Medicine in 1983, is best known for her discovery of transposable genetic elements in corn. This chapter provides an overview of many of her key findings, some of which have been outlined and described elsewhere. We also provide a new look at McClintock’s early contributions, based on our readings of her primary publications and documents found in archives. We expect the reader will gain insight and appreciation for Barbara McClintock’s unique perspective, elegant experiments and unprecedented scientific achievements. 1 Introduction This chapter is focused on the scientific contributions of Barbara McClintock, pioneering plant geneticist and winner of the Nobel Prize in Physiology or Medicine in 1983 for her discovery of transposable genetic elements in corn. Her enlightening experiments and discoveries have been outlined and described in a number of papers and books, so it is not the aim of this report to detail each step in her scientific career and personal life but rather highlight many of her key findings, then refer the reader to the original reports and more detailed reviews. We hope the reader will gain insight and appreciation for Barbara McClintock’s unique perspective, elegant experiments and unprecedented scientific achievements. Barbara McClintock (1902–1992) was born in Hartford Connecticut and raised in Brooklyn, New York (Keller 1983). She received her undergraduate and graduate education at the New York State College of Agriculture at Cornell University. In 1923, McClintock was awarded the B.S.
  • Structure & Symmetry

    Structure & Symmetry

    HAPPY HOLIDAYS ASBMB MEMBERS December 2008 Structure & Symmetry American Society for Biochemistry and Molecular Biology J\\PfliGifk\`ej n`k_*.#'''>=G$kX^^\[FI=Zcfe\j 8 $@C- 9 "@C- : ; >=G$kX^^\[Kil\FI=Zcfe\jXi\kiXej]\Zk\[`ekf?<B)0* Z\ccjXe[k_\kX^^\[gifk\`ejXi\m`jlXc`q\[[li`e^@C$- `e[lZ\[elZc\XikiXejcfZXk`feJK8K*#gXe\c8Xe[9 Xe[`e Ôcfgf[`XXe[jki\jjÔY\i]fidXk`fe8Zk`e#gXe\c:Xe[; % Kil\FI= Fi`>\e\jXclk\j >\efd\n`[\FI=Zcfe\j k_\>=Gg`fe\\ij ]fik_\`iEfY\c ]fikX^^\[gifk\`e\ogi\jj`fe Gi`q\XnXi[ ×:$k\id`eXckX^f]>=G ×J\hl\eZ\m\i`Ô\[Xe[^lXiXek\\[ ×<Xj`cpj_lkkc\[`ekf)'[\jk`eXk`fem\Zkfij ×KiXej]\Zk`fe$i\X[p1('l^gcXjd`[;E8 fi`^\e\%Zfd&fi] ORG-041-GFPTaggedAd_ASBMB_v7.indd 1 10/20/08 12:29:39 PM contents DECEMBER 2008 ON THE COVER: Captivated by the symmetry society news of molecular structure, Sung-Hou Kim has been a 2 From the Editor leader in revealing symmetry 3 President’s Message through his studies in crystallography and 5 Letters to the Editor structural genomics. 30 6 Washington Update 12 Retrospective: Anthony G. San Pietro FASEB releases new Breakthroughs in special interest Bioscience. 6 13 Science’s Role in Foreign Policy 14 ASBMB Round Table: Jim Wells and Mary Woolley 16 Keeping Women in Science 19 Grammar and Writing Tips 2009 meeting 20 The 2009 Fritz Lipmann Lectureship: Douglas C. Rees 21 The 2009 ASBMB Merck Award: John Kuriyan 22 The 2009 FASEB Excellence in Science Award: Susan Lindquist science focus 30 Sung-Hou Kim: Consummate Crystallographer departments 7 News from the Hill 10 Member Spotlight 23 Education and Training A leaky pipeline for women scientists.
  • Science & Policy Meeting Jennifer Lippincott-Schwartz Science in The

    Science & Policy Meeting Jennifer Lippincott-Schwartz Science in The

    SUMMER 2014 ISSUE 27 encounters page 9 Science in the desert EMBO | EMBL Anniversary Science & Policy Meeting pageS 2 – 3 ANNIVERSARY TH page 8 Interview Jennifer E M B O 50 Lippincott-Schwartz H ©NI Membership expansion EMBO News New funding for senior postdoctoral In perspective Georgina Ferry’s enlarges its membership into evolution, researchers. EMBO Advanced Fellowships book tells the story of the growth and ecology and neurosciences on the offer an additional two years of financial expansion of EMBO since 1964. occasion of its 50th anniversary. support to former and current EMBO Fellows. PAGES 4 – 6 PAGE 11 PAGES 16 www.embo.org HIGHLIGHTS FROM THE EMBO|EMBL ANNIVERSARY SCIENCE AND POLICY MEETING transmissible cancer: the Tasmanian devil facial Science meets policy and politics tumour disease and the canine transmissible venereal tumour. After a ceremony to unveil the 2014 marks the 50th anniversary of EMBO, the 45th anniversary of the ScienceTree (see box), an oak tree planted in soil European Molecular Biology Conference (EMBC), the organization of obtained from countries throughout the European member states who fund EMBO, and the 40th anniversary of the European Union to symbolize the importance of European integration, representatives from the govern- Molecular Biology Laboratory (EMBL). EMBO, EMBC, and EMBL recently ments of France, Luxembourg, Malta, Spain combined their efforts to put together a joint event at the EMBL Advanced and Switzerland took part in a panel discussion Training Centre in Heidelberg, Germany, on 2 and 3 July 2014. The moderated by Marja Makarow, Vice President for Research of the Academy of Finland.
  • Division of Extramural Activities Annual Report 2002

    Division of Extramural Activities Annual Report 2002

    Division of Extramural Activities Annual Report 2002 National Institutes of Health National Cancer Institute Molecular Diagnosis of Cancer Gene expression profiling using DNA microarrays is a technology that arose as a consequence of the Human Genome Project. With DNA microarrays, it is possible to determine the activity (“expression”) of tens of thousands of genes in parallel on microarray plates. The expression of genes influences the biological behavior of a cell because it dictates which proteins the cell can make and gives cells their unique characteristics. In the DNA microarray images shown at the bottom of the cover illustration, each spot represents a different human gene. Red, yellow, and green spots indicate that a gene is expressed at high, intermediate, and low levels, respectively. The pattern of expression of all of the genes in a cell constitutes its gene expression “profile.” Using DNA microarrays, different types of normal and malignant cells can be distinguished from one another because they have distinct gene expression profiles. Shown at the top of the cover illustration are photomicrographs of lymph node biopsies from two patients with diffuse large B cell lymphoma. The tumor at the right belongs to the germinal center B cell-like subgroup of diffuse large B cell lymphoma. Patients with this lymphoma type have a relatively favorable 5-year survival rate of 59% following multi-agent chemotherapy. The tumor at the left belongs to the activated B cell-like subgroup of diffuse large B cell lymphoma. Patients with this lymphoma type have a less favorable 5-year survival rate of 31%. Although the tumors from these patients were indistinguishable histologically, they had striking differences in their gene expression profiles, as exemplified by the microarray images shown below each lymphoma subgroup.
  • NIH Conflict of Interest Regs Revised

    NIH Conflict of Interest Regs Revised

    OCTOBEROCTOBER 2005 www.asbmb.org Constituent Society of FASEB AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY NIH Conflict of Interest Regs Revised SEE PAGE 30 FOR NEW CLARA BENSON TRAVEL FELLOWSHIP AWARD Held in conjunction with EB2006 Custom Antibodies Your Way! Choose the protocol that is right for you! QwikScreen ™: 65 day, 2 rabbit protocol - 4 immunizations, 3 bleeds/rabbit (~100ml serum), customer supplied peptide/protein - Options: Peptide synthesis, immunograde Conjugation to carrier u ELISA u u Animal extensionsMS analysis $685 Standard: 80 day, 2 rabbit protocol - 5 immunizations, 5 bleeds/rabbit (~ 200ml ser Options: um), ELISA, customer supplied peptide/pr Peptide synthesis MS Check™ peptide sequence confirmation u HPLC purified peptide Affinity purification otein - Pinnacle: $975 u HPLC and MS analysis u Complete Affinity Purified Protocol- Animal extensions 2 rabbit pr 5 bleeds/rabbitotocol, (~ 200mlepitope serum), design, peptide PhD technical synthesis support, (up to 20mer),5 immunizations, HPLC purified to ~85%, 5+mg peptide to customer, ELISA, evaluation period, affinity purification, and morMS Check™ peptide sequence confirmationNo Hidden Charges! e… - Discounts for Multiple Protocols$1795 , Includes peptide sequencing by CID MS/MS– u Guaranteed Peptide Let our enthusiasm for scienceExpert workTechnical for SupportFidelity! P: 508.303.8222 www.21stcenturybio.com Toll-free: 877.217.8238 F: 508.303.8333 you! E: [email protected] www.asbmb.org AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY OCTOBER