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11Th International Symposium on Neural Regeneration THE ELEVENTH INTERNATIONAL SYMPOSIUM ON NEURAL REGENERATION December 14-18, 2005 Pacific Grove, California i Host and Sponsors ii Committee and Acknowledgements iii Introduction: Eleventh International Symposium on Neural Regeneration vi Scientific Program 2 Abstracts of Oral Presentations 10 Abstracts of Poster Presentations - Session I 30 Abstracts of Poster Presentations - Session II 50 Author Index OFFICE OF THE INTERNATIONAL SYMPOSIUM ON NEURAL REGENERATION THE ELEVENTH INTERNATIONAL SYMPOSIUM ON NEURAL REGENERATION Hosted by: U.S. Department of Veterans Affairs International Symposium on Neural Regeneration (Biomedical Laboratory Research and Development Service) (Office of Research and Development) Co-sponsored by: Paralyzed Veterans of America (Education Foundation) National Institutes of Health (National Institute of Neurological Disorders and Stroke) (Office of Rare Diseases) Christopher Reeve Paralysis Foundation United Spinal Association Shapiro Spinal Cord Research Foundation i THE ELEVENTH INTERNATIONAL SYMPOSIUM ON NEURAL REGENERATION December 14-18, 2005 Asilomar Conference Grounds Phone: (813) 642-4222 800 Asilomar Boulevard Fax: (813) 642-4261 Pacific Grove, California CA 93950 Web: www.VisitAsilomar.com SYMPOSIUM DIRECTOR Roger D. Madison (VA Medical Center and Duke University, Durham, NC) PROGRAM PLANNING COMMITTEE Marie Filbin (Hunter College, New York, NY) David Gardiner (University of California, Irvine, CA) Jane Lebkowski (Geron Corporation, Menlo Park, CA) Michael Sofroniew (University of California, Los Angeles, CA) John Steeves (University of British Columbia,Vancouver, BC) Guest Participants: Vivian Beyda (United Spinal Association, Jackson Heights, NY) Naomi Kleitman (NIH-NINDS) Patricia Dorn (VA Rehabilitation Research and Development—Washington, DC) PROGRAM AND TECHNICAL ASSISTANTS Emily Dings (VA Medical Center, Durham, NC) S. Rao Chadaram (VA Medical Center, Durham, NC) Rodney F. Williams (International Symposium on Neural Regeneration) ACKNOWLEDGEMENTS The symposium is sponsored by the US Department of Veterans Affairs (Biomedical Laboratory Research and Development Service, Office of Research and Development), the Paralyzed Veterans of America (Education Foundation), the National Institutes of Health (National Institute of Neurological Disorders and Stroke, and the Office of Rare Diseases), the Christopher Reeve Paralysis Foundation, the United Spinal Association, and the Shapiro Spinal Cord Research Foundation. We thank Springer Press for assis- tance with printing the program materials. Cover photograph by S. Rao Chadaram. Cover and abstract booklet design by Ms. Emily Dings. ii INTRODUCTION The Eleventh International Symposium on Neural Regeneration will be held at the Asilomar Conference Center in Pacific Grove, California from December 14-18, 2005. The International Symposium on Neural Regeneration began in 1985, and has been held on a biennial basis since that time. The primary sponsor has been the Department of Veterans Affairs, with the NIH continuously co-sponsoring the symposia since 1987. Long-term generous support has also been given by the Paralyzed Veterans of America, Eastern Paralyzed Veterans Association (now United Spinal Association), and more recently the Christopher Reeve Paralysis Foundation. The 2005 symposium will be the eleventh meeting in this series and is the second to also be sponsored in part by a generous donation from the Shapiro Spinal Cord Research Foundation. The generous support of all of our sponsors is gratefully acknowledged. The keynote speaker for this year’s symposium will be Jerry Silver from Case Western Reserve University. This year the keynote address is given in honor of Christopher Reeve who passed away in 2004. Featured talks will be given by John Steeves from the University of British Columbia, Miguel Nicolelis from Duke University, Steve Goldman from the University of Rochester Medical Center, Ed Wirth III from Geron Corporation, Jeff Lichtman from Harvard University, and Paul Martin from The Ohio State University. Following the format of preceding neural regeneration symposia, the program is divided into six sessions, including: 1) Autonomic Dysfunctions and the Long-Term Effects on the Aging SCI Population, chaired by Kimberly D. Anderson; 2) Growth/Plasticity and Functional Outcome, chaired by Harry Goshgarian; 3) Intrinsic Mechanisms Underlying the Initiation of Nerve Regeneration, chaired by Larry Benowitz; 4) Increasing Inflammation Is Beneficial for Neural Repair and Outcome (debate), chaired by Keith Crutcher; 5) Convergent Signaling Regulating Axon Growth, chaired by Marie Filbin; and 6) Emerging Topics,chaired by Michael Sofroniew. The abstracts for the speaker presentations as well as 113 poster presentations are given in the program on the following pages. The primary purpose of the symposium is to present current work in neural regeneration, especially in those areas of research in which there has been some notable recent progress or in which some particularly interest- ing issues have been raised.A secondary purpose is to foster an atmosphere that is both stimulating and con- ducive to a free interchange of ideas among investigators, or between seasoned investigators and students. The International Neural Regeneration Symposium has become an established, regularly occurring event with high attendance by both students as well as internationally recognized experts in the field of neural regeneration. The 12th International Symposium is being scheduled for December 2007 at the Asilomar Conference Center. Roger Madison, Ph.D. Director, International Symposium on Neural Regeneration Laboratory of Nerve Regeneration Duke University Medical Center Research Career Scientist Veterans Affairs Medical Center Building 16/Room 38 508 Fulton Street Durham, NC 27705 iii iv TABLE OF CONTENTS Host and Sponsors..............................................................................................................................i Committee and Acknowledgements...............................................................................................ii Introduction: Eleventh International Symposium on Neural Regeneration.......................... iii Roger Madison, Ph.D. Scientific Program................................................................................................................................vi Poster Presentations.......................................................................................................................... x Abstracts of Oral Presentations......................................................................................................2 Abstracts of Poster Presentations—Session I..............................................................................10 Abstracts of Poster Presentations—Session II............................................................................ 29 Author Index........................................................................................................................................50 v SCIENTIFIC PROGRAM Wednesday, December 14, 2005 3:00 PM Arrival of participants and check-in Poster Session I set-up (pins provided) 6:00 PM Dinner 7:30 PM Welcome and Keynote Address Jerry Silver Case Western Reserve University—Cleveland, Ohio, USA “Regeneration Beyond the Glial Scar” Thursday, December 15, 2005 Session One: 8:15AM Autonomic Dysfunctions and the Long-Term Effects on the Aging Spinal Cord-Injured Population 8:15 AM Chairperson’s Introduction Kimberly D.Anderson University of California, Irvine—California, USA 8:30 AM Video: SCI patient speaking about daily function 9:00 AM Michael D. Craggs Royal National Orthopaedic Hospital, NHS Trust—Middlesex, England “Repeated autonomic dysreflexia episodes stimulated by bladder and bowel dysfunction: Implications for the aging SCI population” 9:30 AM Stacy Elliott University of British Columbia—Vancouver, BC, Canada “Autonomic dysreflexia with sexual activity: Do the benefits outweigh the risks?” 10:00 AM Christopher Mathias Imperial College of Science,Technology and Medicine—–London, England “Hypotension and hypertension in SCI: Short- and long-term implications” 10:30 AM Break 11:00 AM Featured Speaker John Steeves University of British Columbia/International Collaboration on Repair Discoveries—Vancouver, BC, Canada “Guidelines for the conduct of SCI clinical trials” 12:00 Noon Lunch 1:00 PM Viewing: Poster Session I 5:00 PM Featured Speaker Miguel Nicolelis Duke University–Durham, NC, USA “Computing with neural ensembles” 6:00 PM Dinner vi ELEVENTH INTERNATIONAL SYMPOSIUM ON NEURAL REGENERATION Session Two: 7:15PM Growth/Plasticity and Functional Outcome 7:15 PM Chairperson’s Introduction Harry Goshgarian Wayne State University School of Medicine—Detroit, MI, USA 7:30 PM John H. Martin Columbia University—New York, NY, USA “Bypassing spinal injury to promote motor function” 8:00 PM John Houle Drexel University College of Medicine—Philadelphia, PA, USA “Combinatorial treatment strategy to overcome astroglial barriers and promote functional axonal regeneration after spinal cord injury” 8:30 PM Gwendolyn L. Kartje Edward Hines, Jr.VA Hospital—Hines, IL, USA “Recovery and structural plasticity after stroke and Anti-Nogo antibody therapy in adult and aged rats” 9:00 PM Blair Calancie SUNY Upstate Medical University—Syracuse, NY, USA “Neurophysiologic testing for predicting outcome after acute spinal cord injury: Simple, well- tolerated and accurate...but is it useful?” Friday, December 16, 2005
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