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N-Acetylcysteine in the Treatment of Excoriation Disorder: a Randomized Clinical Trial
This supplement contains the following items: 1. Original protocol, final protocol, summary of changes 2. Original statistical analysis plan, final statistical analysis plan, summary of changes Downloaded From: https://jamanetwork.com/ on 09/28/2021 ORIGINAL PROTOCOL A Double-Blind, Placebo-Controlled Study of N-Acetyl Cysteine in Pathologic Skin Picking Jon E. Grant, M.D., J.D, M.P.H. University of Minnesota School of Medicine Minneapolis, MN IRB Code #1002M77897 Protocol Version 25 January 2010 TASCS# 100028 assigned to this protocol !1 Downloaded From: https://jamanetwork.com/ on 09/28/2021 A Double-Blind, Placebo-Controlled Study of N-Acetyl Cysteine in Pathologic Skin Picking This project will take place at the University of Minnesota, Department of Psychiatry. Dr. Jon E. Grant, MD, JD, MPH is the Principal Investigator and can be phoned at 612-273-9736, email at [email protected] or by mail at 2450 Riverside Avenue, Minneapolis, MN 55454. This clinical trial will be conducted in the spirit of Good Clinical Practice (GCP) and in accordance with this IRB approved protocol. No deviation from the protocol will be implemented without the prior review and approval of the IRB except where it may be necessary to eliminate an immediate hazard to a research subject. In such a case, the deviation will be reported to the IRB as soon as possible. Investigational Agent N-acetyl cysteine (NAC) – 600mg by mouth twice a day for three weeks; 1200mg by mouth twice a day for three weeks; 1200mg by mouth each morning and 1800mg by mouth every afternoon for three weeks. -
Increased Tactile Sensitivity and Deficient Feed-Forward Inhibition in Pathological Hair Pulling and Skin Picking
Behaviour Research and Therapy 120 (2019) 103433 Contents lists available at ScienceDirect Behaviour Research and Therapy journal homepage: www.elsevier.com/locate/brat Increased tactile sensitivity and deficient feed-forward inhibition in pathological hair pulling and skin picking T ∗ David C. Houghtona,b, , Mark Tommerdahlc, Douglas W. Woodsb,d a Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, 29425, USA b Psychological & Brain Sciences Department, Texas A&M University, College Station, TX, 77843, USA c Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC, 27599, USA d Department of Psychology, Marquette University, Milwaukee, WI, 53233, USA ARTICLE INFO ABSTRACT Keywords: An increasing body of evidence has linked pathological body-focused repetitive behaviors (BFRBs) to excessive Trichotillomania sensory sensitivity and difficulty modulating sensory inputs. Likewise, neurobiological evidence points to deficits Excoriation disorder in feed-forward inhibition and sensory habituation in conditions with similar symptomatology. There is cur- Psychophysics rently little evidence regarding potential physiological sensory abnormalities in BFRBs. The current study Sensation compared 46 adults with pathological hair pulling and/or skin picking to 46 age-matched healthy control participants on a series of self-report measures and objective psychophysical tests of neurophysiological sensory functions. Persons in the BFRB group reported increased scores on the Sensory Gating Inventory (U=320.50, p < .001) and all of its subscales (all p-values < .001), reflecting abnormal sensory experiences. The BFRB 2 group also showed decreased tactile thresholds (increased sensitivity) (F[1, 76] = 10.65, p = .002, ηp = .12) 2 and deficient feed-forward inhibition (F[1, 76] = 5.18, p = .026, ηp = .064), but no abnormalities in quickly- adapting sensory habituation were detected on an amplitude discrimination task. -
Medically Unexplained Symptoms Evidence Update
1 Medically Unexplained Symptoms Evidence Update June 2017 (Quarterly) February 2016 2 Training Sessions 2017 All sessions are 1 hour May (13.00) Fri 26th Interpreting Statistics Wed 31st Critical Appraisal June (12.00) Thurs 1st Literature Searching Thurs 8th Interpreting Statistics Tues 13th Critical Appraisal th Thurs 29 Literature Searching July (13.00) Mon 3rd Interpreting Statistics Wed 12th Critical Appraisal Fri 21st Literature Searching Wed 26th Interpreting Statistics Your Outreach Librarian: Jo Hooper Whatever your information needs, the library is here to help. Just email us at [email protected] Outreach: Your Outreach Librarian can help facilitate evidence-based practice for all in the team, as well as assisting with academic study and research. We also offer one-to-one or small group training in literature searching, critical appraisal and medical statistics. Get in touch: [email protected] Literature searching: We provide a literature searching service for any library member. For those embarking on their own research it is advisable to book some time with one of the librarians for a one-to-one session where we can guide you through the process of creating a well-focused literature research. Please email requests to [email protected] 3 Updates Aerobic exercise training for adults with fibromyalgia Source: Cochrane Database of Systematic Reviews - 21 June 2017 Read Summary Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews Source: Cochrane Database of Systematic Reviews - 24 April 2017 - Publisher: Cochrane Database of Systematic Reviews Read Summary Psychological Interventions for Children with Functional Somatic Symptoms: A Systematic Review and Meta-Analysis Source: PubMed - 14 April 2017 - Publisher: The Journal Of Pediatrics Read Summary Exercise therapy for chronic fatigue syndrome Lillebeth Larun , Kjetil G. -
2006 Neurologic and Developmental Features of the Smith-Magenis
Review Article Neurologic and Developmental Features of the Smith-Magenis Syndrome (del 17p11.2) Andrea L. Gropman, MD*† Wallace C. Duncan, PhD‡ and Ann C. M. Smith, MA, DSc (Hon)§ʈ The Smith-Magenis syndrome is a rare, complex mul- togenetic analysis help to bring cases to clinical recog- tisystemic disorder featuring, mental retardation and nition at an earlier age, this review seeks to increase multiple congenital anomalies caused by a heterozy- clinical awareness about Smith-Magenis syndrome by gous interstitial deletion of chromosome 17p11.2. The presenting the salient features observed at different phenotype of Smith-Magenis syndrome is character- ages including descriptions of the neurologic and be- ized by a distinct pattern of features including infantile havioral features. Detailed review of the circadian hypotonia, generalized complacency and lethargy in rhythm disturbance unique to Smith-Magenis syn- infancy, minor skeletal (brachycephaly, brachydac- drome is presented. Suggestions for management of the tyly) and craniofacial features, ocular abnormalities, behavioral and sleep difficulties are discussed in the middle ear and laryngeal abnormalities including context of the authors’ personal experience in the hoarse voice, as well as marked early expressive speech setting of an ongoing Smith-Magenis syndrome natural and language delays, psychomotor and growth retar- history study. © 2006 by Elsevier Inc. All rights dation, and a 24-hour sleep disturbance. A striking reserved. neurobehavioral pattern of stereotypies, hyperactivity, polyembolokoilamania, onychotillomania, maladaptive Gropman A, Duncan W. Neurologic and Developmental and self-injurious and aggressive behavior is observed Features of the Smith-Magenis Syndrome (del 17p11.2). with increasing age. The diagnosis of Smith-Magenis Pediatr Neurol 2006;34:337-350. -
Common Dermatoses in Patients with Obsessive Compulsive Disorders Mircea Tampa Carol Davila University of Medicine and Pharmacy, Tampa [email protected]
Journal of Mind and Medical Sciences Volume 2 | Issue 2 Article 7 2015 Common Dermatoses in Patients with Obsessive Compulsive Disorders Mircea Tampa Carol Davila University of Medicine and Pharmacy, [email protected] Maria Isabela Sarbu Victor Babes Hospital for Infectious and Tropical Diseases, [email protected] Clara Matei Carol Davila University of Medicine and Pharmacy Vasile Benea Victor Babes Hospital for Infectious and Tropical Diseases Simona Roxana Georgescu Carol Davila University of Medicine and Pharmacy Follow this and additional works at: http://scholar.valpo.edu/jmms Part of the Medicine and Health Sciences Commons Recommended Citation Tampa, Mircea; Sarbu, Maria Isabela; Matei, Clara; Benea, Vasile; and Georgescu, Simona Roxana (2015) "Common Dermatoses in Patients with Obsessive Compulsive Disorders," Journal of Mind and Medical Sciences: Vol. 2 : Iss. 2 , Article 7. Available at: http://scholar.valpo.edu/jmms/vol2/iss2/7 This Review Article is brought to you for free and open access by ValpoScholar. It has been accepted for inclusion in Journal of Mind and Medical Sciences by an authorized administrator of ValpoScholar. For more information, please contact a ValpoScholar staff member at [email protected]. JMMS 2015, 2(2): 150- 158. Review Common dermatoses in patients with obsessive compulsive disorders Mircea Tampa1, Maria Isabela Sarbu2, Clara Matei1, Vasile Benea2, Simona Roxana Georgescu1 1 Carol Davila University of Medicine and Pharmacy, Department of Dermatology and Venereology 2 Victor Babes Hospital for Infectious and Tropical Diseases, Department of Dermatology and Venereology Corresponding author: Maria Isabela Sarbu, e-mail: [email protected] Running title: Dermatoses in obsessive compulsive disorders Keywords: Factitious disorders, obsessive-compulsive disorders, acne excoriee www.jmms.ro 2015, Vol. -
Included Diagnosis List
Press TAB to Diagnosis Diagnosis Description Code F20.0 Paranoid Schizophrenia F20.1 Disorganized Schizophrenia F20.2 Catatonic Schizophrenia F20.3 Undifferentiated Schizophrenia F20.5 Residual Schizophrenia F20.81 Schizophreniform Disorder F20.89 Other Schizophrenia F20.9 Schizophrenia, Unspecified F21 Schizotypal Disorder F22 Delusional Disorder F23 Brief Psychotic Disorder F24 Shared Psychotic Disorder F25.0 Schizoaffective Disorder, Bipolar Type F25.1 Schizoaffective Disorder, Depressive Type F25.8 Other Schizoaffective Disorders F25.9 Schizoaffective Disorder, Unspecified F28 Other Psychotic Disorder Not Due to a Substance or Known Physiological Condition F29 Unspecified Psychosis Not Due to a Substance or Known Physiological Condition F30.10 Manic Episode Without Psychotic Symptoms, Unspecified F30.11 Manic Episode Without Psychotic Symptoms, Mild F30.12 Manic Episode Without Psychotic Symptoms, Moderate F30.13 Manic Episode, Severe, Without Psychotic Symptoms F30.2 Manic Episode, Severe, With Psychotic Symptoms F30.3 Manic Episode in Partial Remission F30.4 Manic Episode in Full Remission F30.8 Other Manic Episodes F30.9 Manic Episode, Unspecified F31.0 Bipolar Disorder, Current Episode Hypomanic F31.10 Bipolar Disorder, Current Episode Manic, Without Psychotic features, Unspecified F31.11 Bipolar Disorder, Current Episode Manic, Without Psychotic Features, Mild F31.12 Bipolar Disorder, Current Episode Manic, Without Psychotic Features, Moderate F31.13 Bipolar Disorder, Current Episode Manic, Without Psychotic Features, Severe F31.2 -
TLC Scilit Zine 2021 Semifinal.Pdf
Table of Contents / Reference List First Quarter (December 2019-February 2020) Aydin, E. P., Kenar, J. G., Altunay, I. K., Kaymak, D., Özer, Ö. A., & Karamustafalioglu, K. O. (2020). Repetitive transcranial magnetic stimulation in the treatment of skin picking disorder: An exploratory trial. The Journal of ECT, 36 (1), 60-65. Bezerra, A. P., Machado, M. O., Maes, M., Marazziti, D., Nunes-Neto, P. R., Solmi, M., ... & Carvalho, A. F. (2020). Trichotillomania—Psychopathological correlates and associations with health-related quality of life in a large sample. CNS Spectrums, 1-8. Lamothe, H., Schreiweis, C., Lavielle, O., Mallet, L., & Burguière, E. (2020). Not only compulsivity: The SAPAP3-KO mouse reconsidered as a comorbid model expressing a spectrum of pathological repetitive behaviors. BioRxiv, 2020- 01. Stewart, C., & Lipner, S. R. (2020). Insights into recurrent body-focused repetitive behaviors: Evidenced by New York Times commenters. Archives of Dermatological Research, 1-6. Second Quarter (March-June 2020) Grant, J. E., Dougherty, D. D., & Chamberlain, S. R. (2020). Prevalence, gender correlates, and co-morbidity of trichotillomania. Psychiatry Research, 112948. Kaur, I., Jakhar, D., Singal, A., & Grover, C. (2020). Nail care for healthcare workers during COVID-19 pandemic. Indian Dermatology Online Journal, 11(3), 449. Peris, T. S., Piacentini, J., Vreeland, A., Salgari, G., Levitt, J. G., Alger, J. R., ... & O'Neill, J. (2020). Neurochemical correlates of behavioral treatment of pediatric trichotillomania. Journal of Affective Disorders, 273, 552-561. Third Quarter (July-October 2020) Dodds, C. M., & Windget, D. (2020). Body-focused repetitive behaviours are associated with being a ‘creature of habit’. Journal of Behavioral and Cognitive Therapy, 30(3), 223-229. -
Nerve-16-17-Final.Pdf
2 the nerve • 2016-17 CONTENTS R EARCH IN BRIEF 4 - The Diffusive Memristor Gabrielle Abad 9 - Zika Virus & Its Neurological Impacts Srijesa Khasnabish A icles 11 - Excoriation Disorder Emily Yao 14 - Infrared Vision in Snakes Can Yumuk 16 - Conquer Your Mind Mehul Khetrapal 18 - Neuroeconomics Tiantian Li 22 - The Next Generation of Captain America Akane Ichiki 24 - Architecture & Cognition in the Sydney Crotts Monolingual & Bilingual Brain S UDENT R EARCH 26 - Restoring Hearing Loss Andrea Zhang O INION 27 - The Suffering Artist Amanda Fortin 32 - Neuroethics of Identity Erin Ferguson the nerve • 2016-17 3 STAFF Olivia Nguyen Erin Ferguson Colin Stuart Gabrielle Abad Janelle Maxwell Ian Anderson Ben Rabin Sydney Crotts Priyanka Shah Camila de Freitas Josh Strauss Erin Ferguson Colin Stuart Amanda Fortin Emma Wheeler Mehul Khetrapal Ryan Wong Srijesna Khasnabish Emily Yao Katherine Kolin Can Yumuk Tiantian Li Andrea Zhang Haodong Liu Sydney Crotts Martinelli Valcin Radhika Dhanak Valentina Wicki Nic Larstanna Emily Yao Natalya Shelchkova 4 the nerve • 2016-17 LETTER FROM THEE TOR Dear reader, The word ‘neuroscience’ is often intimidating to those who do not pursue the study Janelle Maxwell of the human brain in an academic setting. Yet, with neuroscience research being Ben Rabin one of the largest growing fields to date, it is paramount to make all knowledge ac- cessible without all the scientific jargon in order to propel the general understand- Priyanka Shah ing of our society forward. Having served as editor-in-chief for the Nerve Magazine Josh Strauss for two and a half years, I am continuously humbled and inspired by the passion in Colin Stuart our community to make neuroscience, psychology, biomedical, and other scientific fields more available to the public. -
Obsessive-Compulsive and Related Disorders: a Critical Review of the New Diagnostic Class
CP11CH07-Abramowitz ARI 3 March 2015 12:56 Obsessive-Compulsive and Related Disorders: A Critical Review of the New Diagnostic Class Jonathan S. Abramowitz and Ryan J. Jacoby Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599; email: [email protected] Annu. Rev. Clin. Psychol. 2015. 11:165–86 Keywords First published online as a Review in Advance on obsessive-compulsive disorder, obsessive-compulsive and related disorders, January 2, 2015 trichotillomania, excoriation, hair pulling, hoarding, body dysmorphic The Annual Review of Clinical Psychology is online at disorder clinpsy.annualreviews.org Annu. Rev. Clin. Psychol. 2015.11:165-186. Downloaded from www.annualreviews.org This article’s doi: Abstract 10.1146/annurev-clinpsy-032813-153713 The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders Access provided by University of North Carolina - Chapel Hill on 02/17/16. For personal use only. Copyright c 2015 by Annual Reviews. includes a new class of obsessive-compulsive and related disorders (OCRDs) All rights reserved that includes obsessive-compulsive disorder (OCD) and a handful of other putatively related conditions. Although this new category promises to raise awareness of underrecognized and understudied problems, its empirical va- lidity and practical utility are questionable. This article reviews the phe- nomenology of OCD and then presents a critical analysis of the arguments underlying the new OCRD class. This analysis leads to a rejection of the OCRD classification on both scientific and logical grounds. The article closes with a discussion of the treatment implications of the OCRDs approach. 165 CP11CH07-Abramowitz ARI 3 March 2015 12:56 Contents INTRODUCTION.............................................................. -
Cognitive and Behavioural Characterisitcs Of
COGNITIVE AND BEHAVIOURAL CHARACTERISITCS OF CHILDREN WITH SMITH-MAGENIS SYNDROME Thesis submitted for the degree of Doctorate in Clinical Psychology at the University of Leicester by Carolyn Webber BSc MSc Department of Psychology University of Leicester October 1999 UMI Number: U135663 All rights reserved INFORMATION TO ALL USERS The quality of this reproduction is dependent upon the quality of the copy submitted. In the unlikely event that the author did not send a complete manuscript and there are missing pages, these will be noted. Also, if material had to be removed, a note will indicate the deletion. Dissertation Publishing UMI U135663 Published by ProQuest LLC 2013. Copyright in the Dissertation held by the Author. Microform Edition © ProQuest LLC. All rights reserved. This work is protected against unauthorized copying under Title 17, United States Code. ProQuest LLC 789 East Eisenhower Parkway P.O. Box 1346 Ann Arbor, Ml 48106-1346 ACKNOWLEDGEMENTS I would like to express my sincere gratitude to my project supervisor, Dr Orlee Udwin, for her tremendous support and advice over the last few years, and to Dr Keith Turner for his guidance and encouragement. Special thanks go to all the wonderful parents and children who welcomed me into their homes, without whose co-operation and enthusiasm this project would not have been possible. Finally, thank you to Miles and Tali for being so patient and understanding. ABSTRACT Cognitive and Behavioural Characteristics of Children with Smith-Magenis Syndrome by Carolyn Webber The study aimed to identify behavioural and cognitive characteristics in 29 children with Smith-Magenis syndrome. Cognitive assessments were undertaken on the children, and detailed interviews assessing sleep patterns, maladaptive behaviours, self-injury, hyperactivity and autism were carried out with their parents and teachers. -
Onychophagia and Onychotillomania: Prevalence, Clinical Picture and Comorbidities
Acta Derm Venereol 2014; 94: 67–71 CLINICAL REPORT Onychophagia and Onychotillomania: Prevalence, Clinical Picture and Comorbidities Przemysław PACAN1, Magdalena GRZESIAK1, Adam REICH2, Monika Kantorska-JANIEC1 and Jacek C. Szepietowski2 1Department of Psychiatry, and 2Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland Onychophagia is defined as chronic nail biting behaviour, younger than 3–6 years (8, 9). By the age of 18 years the which usually starts during childhood. Onychotilloma- frequency of this behaviour again decreases; however, nia results from recurrent picking and manicuring of the it may persist into adulthood in some subjects (8, 10). fingernails and/or toenails, leading to visual shortening According to the International Classification of Di- and/or estraction of nails. The aim of this study was to seases and Health Related Problems – 10th Revision assess the prevalence of onychophagia and onychotillo- (ICD-10), nail biting is classified as other specified mania in young adults, and the comorbidity of these con- behavioural and emotional disorders with onset usu- ditions with anxiety disorders and obsessive compulsive ally occurring in childhood and adolescence (F98.8), disorders (OCD), as well as to determine factors related together with excessive masturbation, nose picking, and to these behaviours. A total of 339 individuals were inter- thumb sucking (11). Diagnostic criteria have not been viewed with a structured questionnaire. Onychophagia well described for this group of disorders. was present in 46.9% of participants (including 19.2% Onychophagia seems to be a variant of compulsion, active and 27.7% past nail biters), and an additional 3 which may lead to destruction of the fingernails. -
Obsessive–Compulsive Or Addiction? Categorical Diagnostic Analysis Of
Psychiatry Research 281 (2019) 112518 Contents lists available at ScienceDirect Psychiatry Research journal homepage: www.elsevier.com/locate/psychres Obsessive–compulsive or addiction? Categorical diagnostic analysis of excoriation disorder compared to obsessive-compulsive disorder and T gambling disorder ⁎ Elen Cristina Batista Oliveirraa, , Chelsea L. Fitzpatrickb, Hyoun S. Kimb, Daniel Carr Ribeiro Gulassaa, Roberta Souza Amarala, Nicoli de Mattos Cristianaa, Ana Yaemi Hayashiuchia, Daniel S. McGrathb, Hermano Tavaresa a Programa Ambulatorial de Transtornos do Impulso (PRO-AMITI), Instituto de Psiquiatria (IPq), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Rua Artur de Azevedo, 145, Cerqueira Cesar, CEP: 05404-010, Sao Paulo, SP, Brazil b Department of Psychology, University of Calgary, Calgary, Alberta, Canada ARTICLE INFO ABSTRACT Keywords: Excoriation disorder (ED) is currently classified in the 5th edition of the Diagnostic and Statistical Manual of Excoriation disorder Mental Disorders’ Obsessive–compulsive and Related Disorders section (OCRD). However, there remain debates Skin picking disorder regarding whether ED is related to obsessive–compulsive disorder (OCD) or whether it is better conceptualized – Obsessive compulsive as a behavioral addiction. The present research compared the diagnostic overlap and psychiatric comorbidities Impulse control disorders of 121 individuals seeking treatment for ED (n = 40), OCD (n = 41) and gambling disorder (GD) (n = 40). ED Gambling disorder was more likely to overlap with OCD (n = 14) than GD (n = 3). Compared to OCD, ED had similar frequencies of Comorbidity – DSM-5 other body focused repetitive behaviors (BFRBs), but higher frequency of addictive behaviors (Odds Ratio OR = 11.82). In comparison to GD, ED had similar frequencies of addictive behaviors, but higher frequency of BFRBs (OR=19.67).