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N-Acetylcysteine in the Treatment of Excoriation Disorder: a Randomized Clinical Trial
This supplement contains the following items: 1. Original protocol, final protocol, summary of changes 2. Original statistical analysis plan, final statistical analysis plan, summary of changes Downloaded From: https://jamanetwork.com/ on 09/28/2021 ORIGINAL PROTOCOL A Double-Blind, Placebo-Controlled Study of N-Acetyl Cysteine in Pathologic Skin Picking Jon E. Grant, M.D., J.D, M.P.H. University of Minnesota School of Medicine Minneapolis, MN IRB Code #1002M77897 Protocol Version 25 January 2010 TASCS# 100028 assigned to this protocol !1 Downloaded From: https://jamanetwork.com/ on 09/28/2021 A Double-Blind, Placebo-Controlled Study of N-Acetyl Cysteine in Pathologic Skin Picking This project will take place at the University of Minnesota, Department of Psychiatry. Dr. Jon E. Grant, MD, JD, MPH is the Principal Investigator and can be phoned at 612-273-9736, email at [email protected] or by mail at 2450 Riverside Avenue, Minneapolis, MN 55454. This clinical trial will be conducted in the spirit of Good Clinical Practice (GCP) and in accordance with this IRB approved protocol. No deviation from the protocol will be implemented without the prior review and approval of the IRB except where it may be necessary to eliminate an immediate hazard to a research subject. In such a case, the deviation will be reported to the IRB as soon as possible. Investigational Agent N-acetyl cysteine (NAC) – 600mg by mouth twice a day for three weeks; 1200mg by mouth twice a day for three weeks; 1200mg by mouth each morning and 1800mg by mouth every afternoon for three weeks. -
Increased Tactile Sensitivity and Deficient Feed-Forward Inhibition in Pathological Hair Pulling and Skin Picking
Behaviour Research and Therapy 120 (2019) 103433 Contents lists available at ScienceDirect Behaviour Research and Therapy journal homepage: www.elsevier.com/locate/brat Increased tactile sensitivity and deficient feed-forward inhibition in pathological hair pulling and skin picking T ∗ David C. Houghtona,b, , Mark Tommerdahlc, Douglas W. Woodsb,d a Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, 29425, USA b Psychological & Brain Sciences Department, Texas A&M University, College Station, TX, 77843, USA c Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC, 27599, USA d Department of Psychology, Marquette University, Milwaukee, WI, 53233, USA ARTICLE INFO ABSTRACT Keywords: An increasing body of evidence has linked pathological body-focused repetitive behaviors (BFRBs) to excessive Trichotillomania sensory sensitivity and difficulty modulating sensory inputs. Likewise, neurobiological evidence points to deficits Excoriation disorder in feed-forward inhibition and sensory habituation in conditions with similar symptomatology. There is cur- Psychophysics rently little evidence regarding potential physiological sensory abnormalities in BFRBs. The current study Sensation compared 46 adults with pathological hair pulling and/or skin picking to 46 age-matched healthy control participants on a series of self-report measures and objective psychophysical tests of neurophysiological sensory functions. Persons in the BFRB group reported increased scores on the Sensory Gating Inventory (U=320.50, p < .001) and all of its subscales (all p-values < .001), reflecting abnormal sensory experiences. The BFRB 2 group also showed decreased tactile thresholds (increased sensitivity) (F[1, 76] = 10.65, p = .002, ηp = .12) 2 and deficient feed-forward inhibition (F[1, 76] = 5.18, p = .026, ηp = .064), but no abnormalities in quickly- adapting sensory habituation were detected on an amplitude discrimination task. -
Skin Picking
child & youth Mental Health Series Today’s topic: Speaker: Dr. Erin Kelly November 15, 2018 If you are connected by videoconference: Please mute your system while the speaker is presenting. Complete today’s evaluation & apply for professional credits Please feel free to ask questions! Complete today’s evaluation & apply for professional credits By You will have had an opportunity to registering apply for professional credits or a certificate of attendance for today’s event… You will receive an email with a link to today’s online evaluation Visit our website to download slides You may and view archived events also want to… Sign-up to our distribution list to receive our event notifications Questions? [email protected] Speaker has nothing to disclose with regard to commercial support. Declaration Speaker does not plan to of conflict discuss unlabeled/ investigational uses of commercial product. Goals • What is Excoriation Disorder? • How does it typically present? • Differential diagnoses? • Clinical Correlates? • Management? Excoriation (Skin Picking) Disorder • Repetitive picking, rubbing, scratching, digging, or squeezing of skin, with or without instrumentation, resulting in visible tissue damage and impairment in functioning • Part of a group of disorders characterized by “self-grooming behaviour” in which hair, skin, nails are manipulated. “Body Focused Repetitive Behaviours” or BFRBs Excoriation (Skin Picking) Disorder • Occasional picking at cuticles, acne, scabs, callouses, and other skin abnormalities is a very common -
Included Diagnosis List
Press TAB to Diagnosis Diagnosis Description Code F20.0 Paranoid Schizophrenia F20.1 Disorganized Schizophrenia F20.2 Catatonic Schizophrenia F20.3 Undifferentiated Schizophrenia F20.5 Residual Schizophrenia F20.81 Schizophreniform Disorder F20.89 Other Schizophrenia F20.9 Schizophrenia, Unspecified F21 Schizotypal Disorder F22 Delusional Disorder F23 Brief Psychotic Disorder F24 Shared Psychotic Disorder F25.0 Schizoaffective Disorder, Bipolar Type F25.1 Schizoaffective Disorder, Depressive Type F25.8 Other Schizoaffective Disorders F25.9 Schizoaffective Disorder, Unspecified F28 Other Psychotic Disorder Not Due to a Substance or Known Physiological Condition F29 Unspecified Psychosis Not Due to a Substance or Known Physiological Condition F30.10 Manic Episode Without Psychotic Symptoms, Unspecified F30.11 Manic Episode Without Psychotic Symptoms, Mild F30.12 Manic Episode Without Psychotic Symptoms, Moderate F30.13 Manic Episode, Severe, Without Psychotic Symptoms F30.2 Manic Episode, Severe, With Psychotic Symptoms F30.3 Manic Episode in Partial Remission F30.4 Manic Episode in Full Remission F30.8 Other Manic Episodes F30.9 Manic Episode, Unspecified F31.0 Bipolar Disorder, Current Episode Hypomanic F31.10 Bipolar Disorder, Current Episode Manic, Without Psychotic features, Unspecified F31.11 Bipolar Disorder, Current Episode Manic, Without Psychotic Features, Mild F31.12 Bipolar Disorder, Current Episode Manic, Without Psychotic Features, Moderate F31.13 Bipolar Disorder, Current Episode Manic, Without Psychotic Features, Severe F31.2 -
The Clinical Presentation of Psychotic Disorders Bob Boland MD Slide 1
The Clinical Presentation of Psychotic Disorders Bob Boland MD Slide 1 Psychotic Disorders Slide 2 As with all the disorders, it is preferable to pick Archetype one “archetypal” disorder for the category of • Schizophrenia disorder, understand it well, and then know the others as they compare. For the psychotic disorders, the diagnosis we will concentrate on will be Schizophrenia. Slide 3 A good way to organize discussions of Phenomenology phenomenology is by using the same structure • The mental status exam as the mental status examination. – Appearance –Mood – Thought – Cognition – Judgment and Insight Clinical Presentation of Psychotic Disorders. Slide 4 Motor disturbances include disorders of Appearance mobility, activity and volition. Catatonic – Motor disturbances • Catatonia stupor is a state in which patients are •Stereotypy • Mannerisms immobile, mute, yet conscious. They exhibit – Behavioral problems •Hygiene waxy flexibility, or assumption of bizarre • Social functioning – “Soft signs” postures as most dramatic example. Catatonic excitement is uncontrolled and aimless motor activity. It is important to differentiate from substance-induced movement disorders, such as extrapyramidal symptoms and tardive dyskinesia. Slide 5 Disorders of behavior may involve Appearance deterioration of social functioning-- social • Behavioral Problems • Social functioning withdrawal, self neglect, neglect of • Other – Ex. Neuro soft signs environment (deterioration of housing, etc.), or socially inappropriate behaviors (talking to themselves in -
Nerve-16-17-Final.Pdf
2 the nerve • 2016-17 CONTENTS R EARCH IN BRIEF 4 - The Diffusive Memristor Gabrielle Abad 9 - Zika Virus & Its Neurological Impacts Srijesa Khasnabish A icles 11 - Excoriation Disorder Emily Yao 14 - Infrared Vision in Snakes Can Yumuk 16 - Conquer Your Mind Mehul Khetrapal 18 - Neuroeconomics Tiantian Li 22 - The Next Generation of Captain America Akane Ichiki 24 - Architecture & Cognition in the Sydney Crotts Monolingual & Bilingual Brain S UDENT R EARCH 26 - Restoring Hearing Loss Andrea Zhang O INION 27 - The Suffering Artist Amanda Fortin 32 - Neuroethics of Identity Erin Ferguson the nerve • 2016-17 3 STAFF Olivia Nguyen Erin Ferguson Colin Stuart Gabrielle Abad Janelle Maxwell Ian Anderson Ben Rabin Sydney Crotts Priyanka Shah Camila de Freitas Josh Strauss Erin Ferguson Colin Stuart Amanda Fortin Emma Wheeler Mehul Khetrapal Ryan Wong Srijesna Khasnabish Emily Yao Katherine Kolin Can Yumuk Tiantian Li Andrea Zhang Haodong Liu Sydney Crotts Martinelli Valcin Radhika Dhanak Valentina Wicki Nic Larstanna Emily Yao Natalya Shelchkova 4 the nerve • 2016-17 LETTER FROM THEE TOR Dear reader, The word ‘neuroscience’ is often intimidating to those who do not pursue the study Janelle Maxwell of the human brain in an academic setting. Yet, with neuroscience research being Ben Rabin one of the largest growing fields to date, it is paramount to make all knowledge ac- cessible without all the scientific jargon in order to propel the general understand- Priyanka Shah ing of our society forward. Having served as editor-in-chief for the Nerve Magazine Josh Strauss for two and a half years, I am continuously humbled and inspired by the passion in Colin Stuart our community to make neuroscience, psychology, biomedical, and other scientific fields more available to the public. -
A Call for Research on the Development of MDD with Psychotic Features Christopher P
A Call for Research on the Development of MDD with Psychotic Features Christopher P. M. Courtney Faculty Advisor: Dr. Meredith Montgomery, LPCC-S Part 1: Background Part 2: Literature Review Part 3: Psychosocial Development Neurochemistry Erikson’s Psychosocial Development • The Dopamine Hypothesis states that • Considering Erikson's psychosocial stage theory17, MDD symptoms of psychosis (particularly as w/ psychotic features onset seems to increase with ego seen in schizophrenia, which MDD with development between adolescence & later life18. psychotic features can mimic or even • When the fidelity of adolescence falls to the converse of develop into) can be attributed to a identity, that is, identity confusion19, it throws a normative disturbed dopaminergic signal transduction8 experience into a storm of insecurity, which easily can • Bupropion, better known as Wellbutrin, is start and lead to a core disturbance. Intro and Occurrence Stats currently one of the more prescribed anti-depressants, and according to • Young adulthood then begins as a search for intimacy, as In recent years, Major Depressive Disorder (MDD) is Moreira9 extremely effective in the regulation of clinical depression; those at this stage begin to turn outward in an attempt to becoming more normalized considering medication for it specifically, as it inhibits the reuptake of dopamine through the dopamine share their newfound identity. The antithesis of isolation appears in commercials and other media on a regular basis. and norepinephrine transporters10. It must be noted that this is an enters, as those who failed to reconcile the preceding Psychotic symptoms, an often-misunderstood specifier for unusual function for an anti-depressant, although in this case it allows it to identity conflict feel either that they are psychologically this disorder, are occurring more frequently while being work in tandem with anti-psychotics such as Aripiprazole11. -
Formal Thought Disorder in First-Episode Psychosis
Available online at www.sciencedirect.com ScienceDirect Comprehensive Psychiatry 70 (2016) 209–215 www.elsevier.com/locate/comppsych Formal thought disorder in first-episode psychosis Ahmet Ayera, Berna Yalınçetinb, Esra Aydınlıb, Şilay Sevilmişb, Halis Ulaşc, Tolga Binbayc, ⁎ Berna Binnur Akdedeb,c, Köksal Alptekinb,c, aManisa Psychiatric Hospital, Manisa, Turkey bDepartment of Neuroscience, Dokuz Eylul University, Izmir, Turkey cDepartment of Psychiatry, Medical School of Dokuz Eylul University, Izmir, Turkey Abstract Formal thought disorder (FTD) is one of the fundamental symptom clusters of schizophrenia and it was found to be the strongest predictor determining conversion from first-episode acute transient psychotic disorder to schizophrenia. Our goal in the present study was to compare a first-episode psychosis (FEP) sample to a healthy control group in relation to subtypes of FTD. Fifty six patients aged between 15 and 45 years with FEP and forty five control subjects were included in the study. All the patients were under medication for less than six weeks or drug-naive. FTD was assessed using the Thought and Language Index (TLI), which is composed of impoverishment of thought and disorganization of thought subscales. FEP patients showed significantly higher scores on the items of poverty of speech, weakening of goal, perseveration, looseness, peculiar word use, peculiar sentence construction and peculiar logic compared to controls. Poverty of speech, perseveration and peculiar word use were the significant factors differentiating FEP patients from controls when controlling for years of education, family history of psychosis and drug abuse. © 2016 Elsevier Inc. All rights reserved. 1. Introduction Negative FTD, identified with poverty of speech and poverty in content of speech, remains stable over the course of Formal thought disorder (FTD) is one of the fundamental schizophrenia [7]. -
Early Identification of Psychosis a Primer
Early Identification of Psychosis A Primer Mental Health Evaluation & Community Consultation Unit TABLE OF CONTENTS Introduction...............................................................................................................3 Psychosis and Early Intervention........................................................................4 Why is Early Intervention Needed?...................................................................5 Risk and Onset..........................................................................................................6 Course of First-Episode Psychosis 1. Prodrome........................................................................................................7 2. Acute Phase....................................................................................................8 3. Recovery Phase..............................................................................................9 Summary of First-Episode Psychosis...............................................................11 Tips for Helpers......................................................................................................12 More Resources......................................................................................................15 Acknowledgements...............................................................................................16 2 INTRODUCTION Psychosis is a condition characterized by loss of contact with reality and may involve severe disturbances in perception, cognition, behavior, -
Obsessive-Compulsive and Related Disorders: a Critical Review of the New Diagnostic Class
CP11CH07-Abramowitz ARI 3 March 2015 12:56 Obsessive-Compulsive and Related Disorders: A Critical Review of the New Diagnostic Class Jonathan S. Abramowitz and Ryan J. Jacoby Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599; email: [email protected] Annu. Rev. Clin. Psychol. 2015. 11:165–86 Keywords First published online as a Review in Advance on obsessive-compulsive disorder, obsessive-compulsive and related disorders, January 2, 2015 trichotillomania, excoriation, hair pulling, hoarding, body dysmorphic The Annual Review of Clinical Psychology is online at disorder clinpsy.annualreviews.org Annu. Rev. Clin. Psychol. 2015.11:165-186. Downloaded from www.annualreviews.org This article’s doi: Abstract 10.1146/annurev-clinpsy-032813-153713 The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders Access provided by University of North Carolina - Chapel Hill on 02/17/16. For personal use only. Copyright c 2015 by Annual Reviews. includes a new class of obsessive-compulsive and related disorders (OCRDs) All rights reserved that includes obsessive-compulsive disorder (OCD) and a handful of other putatively related conditions. Although this new category promises to raise awareness of underrecognized and understudied problems, its empirical va- lidity and practical utility are questionable. This article reviews the phe- nomenology of OCD and then presents a critical analysis of the arguments underlying the new OCRD class. This analysis leads to a rejection of the OCRD classification on both scientific and logical grounds. The article closes with a discussion of the treatment implications of the OCRDs approach. 165 CP11CH07-Abramowitz ARI 3 March 2015 12:56 Contents INTRODUCTION.............................................................. -
Schizophrenia Spectrum and Other Psychotic Disorders
1 SCHIZOPHRENIA SPECTRUM AND OTHER PSYCHOTIC DISORDERS 2 OBJECTIVES Know and understand: • How to evaluate a person with psychotic symptoms • The epidemiology and clinical characteristics of late- onset schizophrenia • Evaluation of psychotic symptoms associated with disorders other than schizophrenia • Management of older adult patients with psychotic symptoms 3 TOPICS COVERED • Schizophrenia and Schizophrenia Spectrum Syndromes • Psychotic Symptoms in Delirium and Delusional Disorder • Psychotic Symptoms in Mood Disorder • Psychotic Symptoms in Dementia • Isolated Suspiciousness • Syndromes of Isolated Hallucinations: Charles Bonnet Syndrome • Other Psychotic Disorders Ø Psychotic Disorder Due to Another Medical Condition Ø Substance/Medication-Induced Psychotic Disorder 4 PSYCHOTIC SYMPTOMS • Hallucinations are perceptions without stimuli that can affect any of the 5 sensory modalities (auditory, visual, tactile, olfactory, gustatory) • Delusions are fixed, false, idiosyncratic beliefs that can be: Ø Suspicious (paranoid) Ø Grandiose Ø Somatic Ø Self-blaming Ø Hopeless 5 EVALUATION OF A PERSON WITH PSYCHOTIC SYMPTOMS • First evaluate for underlying causes such as delirium, dementia, stroke, or Parkinson disease Ø Acute onset of altered level of consciousness or inability to sustain attention suggests delirium Ø Delirium, most often superimposed on an underlying dementia, is the most common cause of new-onset psychosis in late life • Next, consider a primary mood disorder • Only after other causes are excluded should the diagnosis of -
Obsessive–Compulsive Or Addiction? Categorical Diagnostic Analysis Of
Psychiatry Research 281 (2019) 112518 Contents lists available at ScienceDirect Psychiatry Research journal homepage: www.elsevier.com/locate/psychres Obsessive–compulsive or addiction? Categorical diagnostic analysis of excoriation disorder compared to obsessive-compulsive disorder and T gambling disorder ⁎ Elen Cristina Batista Oliveirraa, , Chelsea L. Fitzpatrickb, Hyoun S. Kimb, Daniel Carr Ribeiro Gulassaa, Roberta Souza Amarala, Nicoli de Mattos Cristianaa, Ana Yaemi Hayashiuchia, Daniel S. McGrathb, Hermano Tavaresa a Programa Ambulatorial de Transtornos do Impulso (PRO-AMITI), Instituto de Psiquiatria (IPq), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Rua Artur de Azevedo, 145, Cerqueira Cesar, CEP: 05404-010, Sao Paulo, SP, Brazil b Department of Psychology, University of Calgary, Calgary, Alberta, Canada ARTICLE INFO ABSTRACT Keywords: Excoriation disorder (ED) is currently classified in the 5th edition of the Diagnostic and Statistical Manual of Excoriation disorder Mental Disorders’ Obsessive–compulsive and Related Disorders section (OCRD). However, there remain debates Skin picking disorder regarding whether ED is related to obsessive–compulsive disorder (OCD) or whether it is better conceptualized – Obsessive compulsive as a behavioral addiction. The present research compared the diagnostic overlap and psychiatric comorbidities Impulse control disorders of 121 individuals seeking treatment for ED (n = 40), OCD (n = 41) and gambling disorder (GD) (n = 40). ED Gambling disorder was more likely to overlap with OCD (n = 14) than GD (n = 3). Compared to OCD, ED had similar frequencies of Comorbidity – DSM-5 other body focused repetitive behaviors (BFRBs), but higher frequency of addictive behaviors (Odds Ratio OR = 11.82). In comparison to GD, ED had similar frequencies of addictive behaviors, but higher frequency of BFRBs (OR=19.67).