DOCSLIB.ORG

AAI Looks Back

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
AAI Looks Back In This Issue… WINTER 2013 32 Focus2014 AAI on TravelPublic AwardAffairs: ■Applications Government Due Re-opens January 9 after 16-Day Shutdown 3 ■ Focus AAI Recognizeson Public Affairs 2013 ■ CouncilPublic Service Members Award Visit CapitolHonorees Hill, Extol Value 6 AAIof Council NIH Research Welcomes New ■Councillor Congressional JoAnne Budget Flynn 7 JoAnneAgreement L. Flynn’s Scales 2013 Back AAI Candidate’sSequestration Statement Cuts 8 ■Members Council inMembers the News Meet ■ withRandy NIAID Brutkiewicz Director ■ ■ AAIRuslan Public Medzhitov Policy ■ FellowsJoshua ObarProgram: 13 In Memoriam2014 Applications: Due YacovJanuary Ron, 26Ph.D. 146 AAIMembers Looks inBack the News 22 myIDP■ Elected Prepares to IOM: Trainees to TransitionJeff Bluestone to the “FinalRon Frontier” Germain 25 Re-Cap:Warren Summer Leonard 2013 AAI IntroductoryRuslan Medzhitov Immunology CourseGeorg Stingl 26 Re-Cap:■ Mariana Summer Kaplan 2013 AAI ■Advanced Gary Koretzky Immunology Course ■ Song Guo Zheng 28 AAI Members and Staff 14 Participate In Memoriam in 15th ICI 30 AAI■ Len Announces Herzenberg Tiered Awards for the 2014 ■ Trainee Redwan Abstract Moqbel Award 16 AAIProgram Looks Back: 32 GrantMary Hewitt& Award Loveless, Deadlines M.D. 3422 MeetingsOutreach Program& Events Update AAI Looks Back: 24 AAICalendar Welcomes New Members Continuing 28 2014 AAI Introductory, Advance Immunology Reflections Courses Announced on Immunology’s 29 Grant & Award Deadlines 30 Meetings & Events First Century Calendar Creating a Buzz: Remembering Mary Hewitt Loveless and Venom Therapy Page 16 FOCUS ON PUBLIC AFFAIRS AAI Councillors Advocate for NIH Funding on Capitol Hill Councillors Describe Value of Immunological Research delegation of nine AAI Council members Avisited Capitol Hill in December to describe the importance of immunological research and advocate for increased NIH funding. Councillors met with members or staff from 17 congressional offices (L-R) Arlene Sharpe, Marc Jenkins, Mitch Kronenberg, over the course of the day. The visits took place in JoAnne Flynn in front of the U.S. Capitol Building during the fall 2013 AAI Council Capitol Hill Day conjunction with the fall AAI Council meeting and occurred at an optimal time on Capitol Hill, when the budget conference committee was working to reach an agreement (see Congress Reaches Agreement, Passes Budget Which Reduces Sequestration Cuts, next page). Participants included AAI President Marc Jenkins, Past President Gail Bishop, Secretary-Treasurer Mitchell Kronenberg, and Councillors Dan Littman, Arlene Sharpe, Wayne Yokoyama, and JoAnne Flynn. Two ex officio Council members, AAI Publications Committee Chair Eugene Oltz and The Journal of Immunology Editor-in-Chief Pamela Fink, also participated. The Council members were accompanied (L-R) Marc Jenkins, Representative Scott Peters (D-CA, by AAI Committee on Public Affairs Chair Elizabeth 52nd), Mitch Kronenberg, JoAnne Flynn, Arlene Sharpe Kovacs, AAI Director of Public Policy and Government Affairs Lauren Gross, FASEB Director of Legislative Affairs Jennifer Zeitzer, and FASEB Legislative Affairs Analyst Meghan McCabe. Council’s message urging increased support for biomedical research and the NIH was well-received in most congressional offices. However, a number of Capitol Hill staffers cautioned that it will be difficult to provide significant funding increases to any agencies in the current fiscal climate. (L-R) Gail Bishop, Health Policy Director for Senator Charles Grassley (R-IA) Rodney Whitlock, Gene Oltz, Pam Fink (L-R) Liz Kovacs, Marc Jenkins, Staff Director for the Senate Labor, Health and Human Services, and Education Appropriations Subcommittee Adrienne (L-R) Gene Oltz, Legislative Assistant to Senator Claire Hallett, Gail Bishop, Health Policy Advisor to Senator McCaskill (D-MO) Colleen Bell, Wayne Yokoyama, Tom Harkin (D-IA) Andi Fristedt, Dan Littman JoAnne Flynn www.aai.org AAI Newsletter 3 FOCUS ON PUBLIC AFFAIRS (continued) Congress Reaches Agreement, Passes Budget Which Reduces Sequestration Cuts ongress has overwhelmingly approved a budget FY 2013 FY 2014 FY 2015 Cthat will eliminate about one-third of the spending reductions that would have been required under Pre-Sequestration $1.043 trillion $1.058 trillion $1.086 trillion Cap on sequestration over the next two years. The budget Discretionary agreement, formally known as the Bipartisan Budget Act Spending of 2013, was approved by the House of Representatives Post-Sequestration $986 billion (the $967 billion $995 billion (332–94) on December 12 and by the Senate (64–36) on Cap on actual level of Discretionary spending in FY December 18. President Obama signed the legislation Spending 2013) into law on December 26. Bipartisan N/A $1.012 trillion $1.014 trillion The agreement, which was announced on December Budget Act Cap on Discretionary 10 by Senate Budget Committee Chair Patty Murray Spending (D-WA) and House Budget Committee Chair Paul Ryan (R-WI, 1st), provides a broad blueprint for government Although agreeing on topline budget numbers spending but does not set specific spending levels for is an important step forward, the House and Senate federal government agencies, including NIH. Instead, Appropriations Committees still must develop a it sets overall discretionary spending levels for the next bipartisan plan to allocate those funds by January 15, two fiscal years: for FY 2014, it sets the discretionary 2014, when the current continuing resolution expires. spending cap at $1.012 trillion ($45 billion above the Instead of passing individual appropriations bills, sequester cap level of $967 billion but $46 billion lower Congress is likely to pass an omnibus appropriations than the pre-sequestration cap of $1.058 trillion). As bill that includes funding for most or all federal a result, science agencies likely will see an increase in departments, agencies, and programs. funding in FY 2014, though it is unlikely that any of the On December 18, FASEB sent an “e-action” alert agencies will return to their pre-sequestration spending urging recipients to contact their members of Congress levels. Very importantly, the agreement will enable to encourage them to support increased funding for departments and agencies to make strategic choices science agencies. AAI encourages all members to about where and how to make cuts instead of making respond to this alert to make sure that the voices of across-the-board cuts required by sequestration. biomedical researchers are heard on Capitol Hill. NIAID Director Anthony Fauci Briefs AAI Council n December 3, Anthony Fauci, AAI ’73, director programs. He also responded to concerns raised by Oof the National Institute of Allergy and Infectious Council on numerous issues, including the impact Diseases (NIAID), continued his longstanding, annual of sequestration and the urgent need to allocate tradition of visiting with the AAI Council during the additional funding to R01s. Council’s fall meeting. Fauci was accompanied by Hugh Fauci reported that while the NIAID interim R01 Auchincloss, AAI ’83, NIAID principal deputy director, payline for FY 2014 had been set at the 6th percentile and Daniel Rotrosen, AAI ’03, director of the NIAID for established investigators and the 10th percentile Division of Allergy, Immunology, and Transplantation. for new and early-stage investigators, the final paylines Fauci briefed the Council on a variety of issues, could go up once a final appropriations agreement is including how NIH and NIAID were affected by the reached. He also noted that NIAID continues to set federal government shutdown, the current budget aside money for Bridge awards and selective pay. situation, and the status of recently launched NIH 4 AAI Newsletter Winter 2013 AAI Launches Fourth Year of Its To date, 30 AAI members have participated in the program, and AAI looks forward to welcoming up to 10 Public Policy Fellows Program new fellows next spring. Applications Accepted through January 26 For program details or to apply, please visit: http://aai.org/Public_Affairs/PPFP, or contact AAI AI President Marc K. Jenkins and AAI Committee Science Policy and Legislative Affairs Specialist Jake Aon Public Affairs Chair Elizabeth J. Kovacs recently Schumacher at [email protected]. Complete announced that AAI is accepting applications for the application packages are due by January 26, 2014. fourth year of its Public Policy Fellows Program (PPFP). The PPFP engages postdoctoral fellows and junior scientists in a year-long program that teaches how legislative and agency activities impact the conduct and funding of biomedical research and how AAI works on behalf of its members for the best possible outcome. Successful applicants have the opportunity to experience advocacy firsthand on a visit to Capitol Hill and learn more about key issues through public affairs programs at the AAI annual meeting. Except for these two travel experiences, fellows do not need to leave their institutions or labs. The AAI Committee on Public Affairs keeps fellows informed and engaged throughout the year. 2012 AAI PPFP Capitol Hill Day AAI Public Affairs ONLINE Visit us to s ,EARNABOUT.)(FUNDING s +EEPCURRENTONKEYPOLICY ISSUES s $ISCOVERHOWYOUCANHELP !!)INITSADVOCACYINITIATIVES 'OTOwww.aai.org ANDCLICKON Public Affairs. www.aai.org AAI Newsletter 5 Members in the News Five AAI Members Elected to Institute of Medicine AAI members Jeffrey Bluestone (AAI ’82), Ronald Germain Bluestone founded and was the first director of the (AAI ’78), Warren Leonard (AAI ’86), Ruslan Medzhitov
Load more

Recommended publications
  • Scientists Honored for Research Unveiling Molecular Machines the Month of May Brought the Good Prestigious Honors in Science
    june 2012 volume 8, issue 3 Advancing Biomedical Science, Education, and Health Care Scientists honored for research unveiling molecular machines The month of May brought the good prestigious honors in science. On the Campylobacter, which together cause chains of amino acids are formed into news that two School of Medicine 29th, Arthur L. Horwich, m.d., was most of the world’s food-borne illness. three-dimensional, functional struc- scientists, each of whom have done named a winner of the Shaw Prize Galán’s group has thoroughly tures. Misfolded proteins have been pathbreaking work on molecular ma- in Life Science and Medicine, along characterized the Salmonella “needle implicated in many diseases, including chines involved in human disease, had with his longtime scientific col- complex,” a syringe-like organelle Alzheimer’s disease and amyotrophic received high honors for their research. laborator Franz-Ulrich Hartl, m.d., through which the bacterium injects lateral sclerosis (als). On May 1 Jorge E. Galán, ph.d., dr.med., of the Max Planck Institute bacterial proteins into host cells during In 1989, Horwich’s lab, in collabo- d.v.m., chair and Lucille P. Markey of Biochemistry in Germany. infection, modulating the function ration with Hartl and his postdoctoral Professor of Microbial Pathogenesis Galán is renowned for his research of those cells for its own advantage. mentor Walter Neupert m.d., ph.d., and professor of cell biology, was elect- on the cell biology, biochemistry, im- In 2004, Galán and colleagues used discovered a specialized protein in yeast ed a member of the National Academy munobiology, and structural biology of cryoelectron microscopy to visualize called Hsp60 that acts as a protein- of Sciences (nas), one of the most the bacterial pathogens Salmonella and the three-dimensional structure of the folding machine.
    [Show full text]
  • EMBO Conference Takes to the Sea Life Sciences in Portugal
    SUMMER 2013 ISSUE 24 encounters page 3 page 7 Life sciences in Portugal The limits of privacy page 8 EMBO Conference takes to the sea EDITORIAL Maria Leptin, Director of EMBO, INTERVIEW EMBO Associate Member Tom SPOTLIGHT Read about how the EMBO discusses the San Francisco Declaration Cech shares his views on science in Europe and Courses & Workshops Programme funds on Research Assessment and some of the describes some recent productive collisions. meetings for life scientists in Europe. concerns about Journal Impact Factors. PAGE 2 PAGE 5 PAGE 9 www.embo.org COMMENTARY INSIDE SCIENTIFIC PUBLISHING panels have to evaluate more than a hundred The San Francisco Declaration on applicants to establish a short list for in-depth assessment, they cannot be expected to form their views by reading the original publications Research Assessment of all of the applicants. I believe that the quality of the journal in More than 7000 scientists and 250 science organizations have by now put which research is published can, in principle, their names to a joint statement called the San Francisco Declaration on be used for assessment because it reflects how the expert community who is most competent Research Assessment (DORA; am.ascb.org/dora). The declaration calls to judge it views the science. There has always on the world’s scientific community to avoid misusing the Journal Impact been a prestige factor associated with the publi- Factor in evaluating research for funding, hiring, promotion, or institutional cation of papers in certain journals even before the impact factor existed. This prestige is in many effectiveness.
    [Show full text]
  • 1 Achieving a Fair and Effective COVID-19 Response: an Open
    1 Achieving A Fair and Effective COVID-19 Response: An Open Letter to Vice-President Mike Pence, and Other Federal, State, and Local Leaders from Public Health and Legal Experts in the United States Sustained human-to-human transmission of the novel coronavirus in the United States (US) appears today inevitable. The extent and impact of the outbreak in the US is difficult to predict and will depend crucially on how policymakers and leaders react. It will depend particularly on whether there is adequate funding and support for the response; fair and effective management of surging health care demand; careful and evidence-based mitigation of public fear; and necessary support and resources for fair and effective infection control. A successful American response to the COVID-19 pandemic must protect the health and human rights of everyone in the US. One of the greatest challenges ahead is to make sure that the burdens of COVID-19, and our response measures, do not fall unfairly on people in society who are vulnerable because of their economic, social, or health status. We write as experts in public health, law, and human rights, with experience in previous pandemic responses, to set forth principles and practices that should guide the efforts against COVID-19 in the US. It is essential that all institutions, public and private, address the following critical concerns through new legislation, institutional policies, leadership and spending. ADEQUATE FUNDING AND SUPPORT FOR THE RESPONSE MUST BE PROVIDED ● Federal, state and local governments should act immediately to allocate funds to ensure that necessary measures can be carried out and that basic human needs continue to be met as the epidemic unfolds.
    [Show full text]
  • 2015/2016 IMP Research Report
    RESEARCH REPORT 2015–2016 Cover: Connective tissue cells of axolotl finger. (see also p. 34) CONTENTS 02 Highlights 04 Introduction Jan-Michael Peters & Harald Isemann 06 Facts & Figures 8 Current Research 10 Meinrad Busslinger 12 Tim Clausen 14 Luisa Cochella 16 Wulf Haubensak 18 David Keays 20 Thomas Marlovits 22 Anna Obenauf 24 Andrea Pauli 26 Rushad Pavri 28 Jan-Michael Peters 30 Alexander Stark 32 Andrew Straw 34 Elly Tanaka 36 Alipasha Vaziri 38 Stefan Westermann 40 Manuel Zimmer 42 Johannes Zuber 44 What the group leaders say 46 In-house Services 48 BioOptics 49 Bioinformatics 50 Molecular Biology Service 51 Max Perutz Library 52 Mass Spectrometry and Protein Chemistry 53 Comparative Medicine and Transgenic Services 56 The IMP and the VBC 57 Scientific Advisory Board 58 Vienna Biocenter Core Facilities (VBCF) 60 Vienna Biocenter training programme 62 IMP seminar series 66 IMP’s awards and honours 68 Publications 74 Sponsors & partners 76 Imprint IMP RESEARCH REPORT 2015–2016 HIGHLIGHTS As of late 2016, the IMP has a new home. The move marks the grand finale in a series of highlights that the institute enjoyed in 2015/16. The scientific JANUARY Max-Birnstiel Lecture by the search committee for the milestones of the IMP 2015 James Allison of the MD Anderson first IMP Director in the 1980s. are often marked Cancer Center in Houston, Texas: Jeff Schatz passes away not long by publications, “Boosting the Immune System after the lecture, in October 2015. awards, grants and to Fight Cancer”. honours, or talks Max-Birnstiel Lecture by by distinguished MARCH Dignitaries from IMP, Ruslan Medzhitov, Professor of guest lecturers in our 2015 Boehringer Ingelheim, the city of Immunobiology at Yale School on-going seminar Vienna and others gather for of Medicine in New Haven, series.
    [Show full text]
  • Else Kröner Fresenius Award 3
    Zum 25. Todestag von Else Kröner Else Kröner Fresenius2013 Award 2 Else Kröner Fresenius Award 3 Liebe Leser, liebe Freunde und Partner der Else Kröner-Fresenius-Stiftung, mit Freude und Dankbarkeit geben wir Prof. Dr. Ruslan Medzhitov als Preisträger des Else Kröner Fresenius Awards bekannt. Seine For- schung wird unsere Vorstellungen von der Reaktion des Körpers auf Inhalt Infektionen neu definieren. 3 Editorial Ende 2011 beschloss die Else Kröner-Fresenius-Stiftung, zum 25. Todestag ihrer Stifterin ein außergewöhnliches Förderprojekt 4 Preisträger Ruslan Medzhitov: auszuloben: einen substanziellen, zukunftsgerichteten Forschungspreis Weit über die Immunologie hinaus auf einem der spannendsten Gebiete der medizinischen Forschung. Dieser Award soll nicht nur die Werte Else Kröners veranschaulichen, 11 Interview: Warum fühlen wir uns krank sondern auch die Bandbreite ihres Lebenswerks als Unternehmerin bei einem Infekt? und Stifterin. In Erfüllung von Else Kröners Wünschen richtet sich die Stiftungs- 14 Laudatio für Ruslan Medzhitov arbeit sowohl auf wissenschaftliche Inhalte als auch auf begabte junge Forscher. Ausschreibungen für Stipendien, Forschungspreise, Dokto- 16 Die Auswahl des Preisträgers randen- und Forschungskollegs – verschiedene Maßnahmen zielen da- rauf ab, engagierten Forschern Räume zu erschließen und Talente zur 17 Die Jury des Else Kröner Fresenius Awards Entfaltung zu bringen. Der Else Kröner Fresenius Award zeichnet herausragende Forschungs- In ihr Tagebuch schrieb die junge 20 Den Nachwuchs im Blick ergebnisse aus und fördert bedeutende Arbeiten in der Zukunft. Da- Pharmaziestudentin 1948, was zu bei entstehen auch Ausbildungsmöglichkeiten für junge Forscher. Wir einem Leitmotiv ihres Lebens wurde: 22 Sieben Rätsel der Immunologie möchten zeigen, dass in der medizinischen Forschung auch in jungen »Die Wissenschaft will erobert Jahren viel erreicht werden kann und dass die Wissenschaft attraktive sein.« Else Kröner erkannte schon 24 Grafik: Im Kampf gegen Infektionen Karrierewege bietet.
    [Show full text]
  • A Young Scientist Scores Another First
    july/august 2011 volume 7, issue 3 Advancing Biomedical Science, Education, and Health Care Couple’s passion for the arts inspires unique scholarship fund Having majored in philosophy and Association and a Jungian psychoana- to contributions from others, includ- history as an undergraduate at Trinity lyst and psychiatrist in private practice ing a matching gift from the School of College, in Hartford, Conn., David in San Francisco. Medicine to mark the school’s Bicen- Leof, m.d., a member of the School But Leof’s terror quickly evapo- tennial year. of Medicine’s Class of 1964, initially rated, and “as things unfolded, I was Another major influence on Leof found life at the medical school to be just like a little kid at Christmas,” he was Lippard’s successor as dean, “quite terrifying.” On his very first says. “I had an absolutely joyful time Frederick C. Redlich, m.d., a leg- day, then-Dean Vernon W. Lip- in medical school.” endary chair of the Department of pard, m.d., issued a sobering call to In gratitude, Leof and his wife, Psychiatry from 1950 to 1967 who responsibility, reminding the new Colleen, have made a bequest to the built the department into one of the students that medical school is only a School of Medicine of several million nation’s finest. It was Redlich, Leof brief chapter in the life of a physician. dollars, which will support medi- says, who encouraged him to go into Though the day would come when cal students who have distinguished psychiatry himself. After graduating, each student would receive a medical themselves in the arts or humani- Leof interned at Dartmouth College’s degree, “you have the rest of your life ties.
    [Show full text]
  • SABRE Annual Report 2021
    Sandler Asthma Basic REsearch Center University of California, San Francisco Progress Report Year 22 July 2021 Figure Legend: Multi-detector computed tomography (MCTD) lung scan of a patient with poorly controlled asthma revealed occlusive mucus plugs of varying size and shape, which has been shown to correlate with worse lung function (technique developed and refined in the Fahy SABRE Center lab with UCSF Radiology). Therapeutic dissolution of plugs remains a priority in the Fahy lab. (Image contributed by Brendan Huang). TABLE OF CONTENTS Mission Statement 2 Summary of Accomplishments Overview 3 Executive Committee: Members and Functions 24 Scientific Advisory Board Susan Kaech, Ph.D. 26 Mitchell Kronenberg, Ph.D. 27 Ruslan Medzhitov, Ph.D. 28 SABRE Center Investigators Richard Locksley, M.D. 30 Christopher Allen, Ph.D. 32 K. Mark Ansel, Ph.D. 34 Esteban Burchard, M.D., M.P.H. 36 John Fahy, M.D., M.Sc. 38 Jeoung-Sook Shin, Ph.D. 40 Prescott Woodruff, M.D., M.P.H. 42 SABRE Associate Investigators Mallar Bhattacharya, M.D., MSc. 45 Erin Gordon, M.D. 47 Andrew Schroeder, M.P.H. 49 Aparna Sundaram, M.D. 50 Core Facilities Microscopy/BIDC 53 Asthma Related Research Projects Primero Birth Cohort 60 Single Cell Sequencing in Nasal Polyp Patients 70 Contributions to Relevant Scientific Activities 74 Publications Supported by the Sandler Asthma Basic Research Center 79 Looking to the future 136 Biographical Sketches 138 Mission Statement The Sandler Asthma Basic Research Center (SABRE Center) is an investigative unit dedicated to basic research discovery in asthma. Founded in 1999, the SABRE Center is nucleated by basic scientists supported by advanced technology cores and linked with the greater scientific community through Center Grants and Program Projects focused around asthma research.
    [Show full text]
  • Innovating Immunology: an Interview with Ruslan Medzhitov
    A MODEL FOR LIFE Disease Models & Mechanisms 4, 430-432 (2011) doi:10.1242/dmm.008151 Innovating immunology: an interview with Ruslan Medzhitov Ruslan Medzhitov was inspired to become a researcher in immunology on reading a 1989 paper written by Charles Janeway that outlined a new theory for immune system activation. Just a few years later, having achieved a postdoc position in Janeway’s lab, he carried out the experiments that confirmed the theory, re-igniting interest in the field of innate immunity and launching his own career. Here, he discusses this early discovery and explains what he considers the three most important questions facing immunologists today. wo decades ago, the mechanisms Ruslan Medzhitov grew up in the former that led to the activation of the Soviet Union in a large city called Tashkent, adaptive immune system were where he enrolled in college at the age of 18. largely unknown. Adaptive Owing to unusual demographics at that time, immune cells – such as T and B the government extended its compulsory DMM cellsT – and the cytokines that they produce army service to college students for a short had been characterised in some detail, yet period, meaning that he had to spend two how an invading pathogen could induce their years serving in the Russian army before actions was a mystery. In 1989, Charles returning to complete his college education. Janeway proposed in a landmark paper (Janeway, 1989) how this might take place: How did your time in the army influence invariant molecular structures expressed by your academic training? invading pathogens would activate pattern Two years in the Russian army can be very recognition receptors on innate immune damaging – they were probably the most cells, which in turn would trigger the miserable two years of my life.
    [Show full text]
  • Bridging Innate and Adaptive Immunity
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector Leading Edge BenchMark Bridging Innate and Adaptive Immunity William E. Paul1,* 1Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1892, USA *Correspondence: [email protected] DOI 10.1016/j.cell.2011.11.036 The Nobel Prize in Physiology or Medicine for 2011 to Jules Hoffmann, Bruce Beutler, and the late Ralph Steinman recognizes accomplishments in understanding and unifying the two strands of immunology, the evolutionarily ancient innate immune response and modern adaptive immunity. Among the 15 Nobel prizes given for siveness. The celebration of immunolo- the eponymous complete Freund’s adju- discoveries in immunology, including the gists everywhere in response to this vant, consisting of killed Mycobacteria very first, the 2011 prize can be best well-deserved prize is tempered with tuberculosis organisms in a water-in-oil compared to the 1908 prize, shared by sadness, with Ralph Steinman having emulsion. two giants of modern science, Paul died on the Friday preceding the Monday Although this need to use adjuvants to Ehrlich and Ilya Metchnikoff. In awarding announcement of the award. obtain a robust immune response to that prize, the Nobel committee attemp- protein antigens was widely appreciated, ted to grapple with the divide that had Exploring Immunology’s ‘‘Dirty it was papered over as immunologists’ already arisen in the then infant
    [Show full text]
  • Report for the Academic Year 2007-2008
    Institute for Advanced Study IASInstitute for Advanced Study Report for 2007–2008 INSTITUTE FOR ADVANCED STUDY EINSTEIN DRIVE PRINCETON, NEW JERSEY 08540 609-734-8000 www.ias.edu Report for the Academic Year 2007–2008 t is fundamental in our purpose, and our express I. desire, that in the appointments to the staff and faculty, as well as in the admission of workers and students, no account shall be taken, directly or indirectly, of race, religion, or sex. We feel strongly that the spirit characteristic of America at its noblest, above all the pursuit of higher learning, cannot admit of any conditions as to personnel other than those designed to promote the objects for which this institution is established, and particularly with no regard whatever to accidents of race, creed, or sex. Extract from the letter addressed by the Institute’s Founders, Louis Bamberger and Caroline Bamberger Fuld, to the first Board of Trustees, dated June 4, 1930. Newark, New Jersey Cover Photo: Dinah Kazakoff The Institute for Advanced Study exists to encourage and support fundamental research in the sciences and humanities—the original, often speculative, thinking that produces advances in knowledge that change the way we understand the world. THE SCHOOL OF HISTORICAL STUDIES, established in 1949 with the merging of the School of Economics and Politics and the School of Humanistic Studies, is concerned principally with the history of Western European, Near Eastern, and East Asian civilizations. The School actively promotes interdisciplinary research and cross-fertilization of ideas. THE SCHOOL OF MATHEMATICS, established in 1933, was the first School at the Institute for Advanced Study.
    [Show full text]
  • The Din Within Microbial Messaging in the Gut Keeps the Body Humming Vol
    hhmi bulletin • howard hughes medical institute • www.hhmi.org • institute medical hughes howard • bulletin hhmi Fall ’13 Vol. 26 No. 3 4000 Jones Bridge Road Chevy Chase, Maryland 20815-6789 www.hhmi.org Address Service Requested Competitive Streak in this issue Teeming bacteria of all stripes make their home in the gut. Like On Cancer’s Trail siblings sharing a bedroom, the microbes can get a little competitive 2013 Investigators for nutrients and other molecules they need to grow. Katrina Xavier Forest Fires and her research team aim to identify traits that neither help nor hurt Escherichia coli bacteria grown in pure cultures but are beneficial when the bacteria have to compete with other species in a complex environment like the gastrointestinal tract. The macro-colony seen here is a mixture of two mutant E. coli strains that differentially express fluorescently labeled proteins (yellow and blue) when grown in competition on an agar plate. The two markers indicate the fitness of each strain as they compete. To learn more about the team’s work, see “Microbial Social Network,” page 12. The Din Within Microbial messaging in the gut keeps the body humming vol. 26 / no. 3 no. / 26 vol. Ozhan Ozkaya / Xavier Lab Xavier / Ozkaya Ozhan HHMI Bulletin / Fall 2013 For more information: See the feature profile Observations of Bert Vogelstein, “Driven,” on page 18. Knowing the heterogeneity of every cancer, one might naively have presumed that every patient’s cancer possessed its own sequence of gene mutations and its 24 unique set of mutated genes. But Vogelstein Interstellar dust cloud? found a strikingly consistent pattern in his Cancer geneticist already knew two Distant galaxy? Not quite, colon cancer samples: across many samples answers to this question.
    [Show full text]
  • Immunology, Inflammation, and an Oddly Intrigued Conservation Biologist
    Immunology, Inflammation, and an Oddly Intrigued Conservation Biologist Author: Melanie Quain Edited by: Jessica Packard Speaker: Ruslan Medzhitov, Professor of Immunobiology at Yale University School of Medicine “Host Defense Strategies” Pitt Science 2019 Thursday, October 17th 2019 Every year, the University of Pittsburgh holds Pitt Science, a conference open to anyone who is interested in learning about some ground-breaking research happening around the country. At each conference, the most prestigious annual award is given out to that years’ worthy scientist; the Dickson Prize in Medicine is annually awarded to one of the country’s leading researchers who engages themselves in innovative biomedical research. Who will win? Who has what it takes? Why am I asking so many questions when I already know the answer?? This year, the recipient of the 2019 Dickson Prize in Medicine is Ruslan Medzhitov, PhD, one of the world’s leading immunology researchers. Born in Uzbekistan, it was mandatory for Medzhitov to enroll in the Russian army at the age of 18 for two years. Following his service in the army, he dedicated his life to his education and eventually earned his B.S. and followed that degree to pursue his PhD at Moscow State University. He ran into funding issues due to the economic crisis in the Soviet Union in 1990 and later finished his PhD at the University of California, San Diego with Dr. Russell Doolittle and later worked with Dr. Charlie Janeway during his postdoc through researching immunity and inflammation[3]. From not backing down in the world of academics, Medzhitov has been able to achieve a number of accomplishments including being credited with many fundamental discoveries around the importance of Toll-like receptors in controlling adaptive immunity, infections, chronic inflammation, and tumor growth.
    [Show full text]