List of Chemicals the Following Table Includes a List of the Selectable Chemicals in E‐Plan Chemical Plume Model's Library
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(12) Patent Application Publication (10) Pub. No.: US 2005/0065361A1 Deshmukh Et Al
US 2005OO65361A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2005/0065361A1 Deshmukh et al. (43) Pub. Date: Mar. 24, 2005 (54) PROCESS FOR PREPARING ALKYLARYL (22) Filed: Sep. 22, 2003 CHLOROFORMATES Publication Classification (76) Inventors: Abdul Rakeeb Abdul Subhan Deshmukh, Maharashtra (IN); Vikas (51) Int. Cl." ........................... C07C 69/74; C07C 69/96 Kalyanrao Gumaste, Maharashtra (IN) (52) U.S. Cl. .............................................................. 558/280 Correspondence Address: (57) ABSTRACT NIXON & VANDERHYE, PC The present invention discloses an improved method for the 1100 N GLEBE ROAD preparation of alky/aryl chloroformates directly from alco 8TH FLOOR hols and triphosgene. This method is simple, mild and ARLINGTON, VA 22201-4714 (US) efficient avoids use of hazardous phosgene. It can be used for the preparation of various aryl as well as alkyl chlorofor (21) Appl. No.: 10/665,410 mates in excellent yields. US 2005/0065361 A1 Mar. 24, 2005 PROCESS FOR PREPARING ALKYLARYL Maligres, K. C. Nicolau, W. Wrasidio Bioorg. Med. Chem. CHLOROFORMATES Lett. 1993, 3, 1051. (c) D. C. Horwell, J. Hughes, J. Hunter, M. C. Pritchard, R. S. Richardson, E. Roberts, G. N. FIELD OF THE INVENTION Woodruff J. Med. Chem., 1991, 34, 404 and tertiary amines as base H. Eckert, B. Forster, Angew. Chem. Int. Ed. Engl., 0001. The present invention relates to a process for 1987,26,894). Hydroquinone is also used in the preparation preparing alkyl/aryl chloroformates. More particularly, the of chloroformates from triphosgene G. Van den Mooter, C. present invention relates to a process for preparing com Samyn, R. Kinget Int. J. Pharm., 1993, 97, 133). -
Retention Indices for Frequently Reported Compounds of Plant Essential Oils
Retention Indices for Frequently Reported Compounds of Plant Essential Oils V. I. Babushok,a) P. J. Linstrom, and I. G. Zenkevichb) National Institute of Standards and Technology, Gaithersburg, Maryland 20899, USA (Received 1 August 2011; accepted 27 September 2011; published online 29 November 2011) Gas chromatographic retention indices were evaluated for 505 frequently reported plant essential oil components using a large retention index database. Retention data are presented for three types of commonly used stationary phases: dimethyl silicone (nonpolar), dimethyl sili- cone with 5% phenyl groups (slightly polar), and polyethylene glycol (polar) stationary phases. The evaluations are based on the treatment of multiple measurements with the number of data records ranging from about 5 to 800 per compound. Data analysis was limited to temperature programmed conditions. The data reported include the average and median values of retention index with standard deviations and confidence intervals. VC 2011 by the U.S. Secretary of Commerce on behalf of the United States. All rights reserved. [doi:10.1063/1.3653552] Key words: essential oils; gas chromatography; Kova´ts indices; linear indices; retention indices; identification; flavor; olfaction. CONTENTS 1. Introduction The practical applications of plant essential oils are very 1. Introduction................................ 1 diverse. They are used for the production of food, drugs, per- fumes, aromatherapy, and many other applications.1–4 The 2. Retention Indices ........................... 2 need for identification of essential oil components ranges 3. Retention Data Presentation and Discussion . 2 from product quality control to basic research. The identifi- 4. Summary.................................. 45 cation of unknown compounds remains a complex problem, in spite of great progress made in analytical techniques over 5. -
Transport of Dangerous Goods
ST/SG/AC.10/1/Rev.16 (Vol.I) Recommendations on the TRANSPORT OF DANGEROUS GOODS Model Regulations Volume I Sixteenth revised edition UNITED NATIONS New York and Geneva, 2009 NOTE The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the United Nations concerning the legal status of any country, territory, city or area, or of its authorities, or concerning the delimitation of its frontiers or boundaries. ST/SG/AC.10/1/Rev.16 (Vol.I) Copyright © United Nations, 2009 All rights reserved. No part of this publication may, for sales purposes, be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, electrostatic, magnetic tape, mechanical, photocopying or otherwise, without prior permission in writing from the United Nations. UNITED NATIONS Sales No. E.09.VIII.2 ISBN 978-92-1-139136-7 (complete set of two volumes) ISSN 1014-5753 Volumes I and II not to be sold separately FOREWORD The Recommendations on the Transport of Dangerous Goods are addressed to governments and to the international organizations concerned with safety in the transport of dangerous goods. The first version, prepared by the United Nations Economic and Social Council's Committee of Experts on the Transport of Dangerous Goods, was published in 1956 (ST/ECA/43-E/CN.2/170). In response to developments in technology and the changing needs of users, they have been regularly amended and updated at succeeding sessions of the Committee of Experts pursuant to Resolution 645 G (XXIII) of 26 April 1957 of the Economic and Social Council and subsequent resolutions. -
Antimony Pentachloride Apc
ANTIMONY PENTACHLORIDE APC CAUTIONARY RESPONSE INFORMATION 4. FIRE HAZARDS 7. SHIPPING INFORMATION 4.1 Flash Point: 7.1 Grades of Purity: 99+% Common Synonyms Liquid Colorless to brown Unpleasant odor Not flammable 7.2 Storage Temperature: Ambient Antimony (V) chloride 4.2 Flammable Limits in Air: Not flammable Antimony perchloride 7.3 Inert Atmosphere: No requirement 4.3 Fire Extinguishing Agents: Not pertinent Sinks in water. Irritating vapor is produced. Freezing point is 37°F. 7.4 Venting: Pressure-vacuum 4.4 Fire Extinguishing Agents Not to Be 7.5 IMO Pollution Category: Currently not available Avoid contact with liquid. Keep people away. Used: Do not use water or foam on Wear rubber overclothing (including gloves). adjacent fires. 7.6 Ship Type: Currently not available Stop discharge if possible. 4.5 Special Hazards of Combustion 7.7 Barge Hull Type: Currently not available Evacuate. Products: Not pertinent Isolate and remove discharged material. 4.6 Behavior in Fire: Irritating fumes of Notify local health and pollution control agencies. 8. HAZARD CLASSIFICATIONS hydrogen chloride given off when water Protect water intakes. or foam is used to extinguish adjacent 8.1 49 CFR Category: Corrosive material fire. 8.2 49 CFR Class: 8 Not flammable. 4.7 Auto Ignition Temperature: Not pertinent Fire POISONOUS GASES ARE PRODUCED WHEN HEATED. 8.3 49 CFR Package Group: II DO NOT USE WATER ON ADJACENT FIRES. 4.8 Electrical Hazards: Not pertinent 8.4 Marine Pollutant: No 4.9 Burning Rate: Not pertinent 8.5 NFPA Hazard Classification: Exposure Call for medical aid. 4.10 Adiabatic Flame Temperature: Not pertinent Category Classification VAPOR Health Hazard (Blue)......... -
RIFM Fragrance Ingredient Safety Assessment, 2-Isopropyl-4- Methylanisole, CAS Registry Number 31574-44-4
Food and Chemical Toxicology 110 (2017) S545eS551 Contents lists available at ScienceDirect Food and Chemical Toxicology journal homepage: www.elsevier.com/locate/foodchemtox Short review RIFM fragrance ingredient safety assessment, 2-isopropyl-4- methylanisole, CAS Registry Number 31574-44-4 * A.M. Api a, , D. Belsito b, D. Botelho a, D. Browne a, M. Bruze c, G.A. Burton Jr. d, J. Buschmann e, M.L. Dagli f, M. Date a, W. Dekant g, C. Deodhar a, M. Francis a, A.D. Fryer h, K. Joshi a,S.LaCavaa, A. Lapczynski a, D.C. Liebler i,D.O’Brien a, R. Parakhia a,A.Patela, T.M. Penning j, G. Ritacco a, J. Romine a, D. Salvito a, T.W. Schultz k, I.G. Sipes l, Y. Thakkar a, E.H. Theophilus a, A.K. Tiethof a, Y. Tokura m, S. Tsang a, J. Wahler a a Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA b Columbia University Medical Center, Department of Dermatology, 161 Fort Washington Ave., New York, NY 10032, USA c Malmo University Hospital, Department of Occupational & Environmental Dermatology, Sodra Forstadsgatan 101, Entrance 47, Malmo SE-20502, Sweden d School of Natural Resources & Environment, University of Michigan, Dana Building G110, 440 Church St., Ann Arbor, MI 58109, USA e Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai-Fuchs-Strasse 1, 30625 Hannover, Germany f University of Sao Paulo, School of Veterinary Medicine and Animal Science, Department of Pathology, Av. Prof. dr. Orlando Marques de Paiva, 87, Sao Paulo CEP 05508-900, Brazil g University of Wuerzburg, Department of Toxicology, Versbacher Str. -
Synthesis of Bromochloromethane Using Phase Transfer Catalysis
1 SYNTHESIS OF BROMOCHLOROMETHANE USING PHASE TRANSFER CATALYSIS By LANCELOT LUCRETIUS BROOKS Baccalaureus Scientiae Honores-Chemistry, Nelson Mandela Metropolitan University A dissertation submitted in fulfillment of the requirements for the Masters Degree in Chemistry In the Faculty of Science at the NELSON MANDELA METROPOLITAN UNIVERSITY Nov. 2011 Promoter : Dr G. Dugmore Co-Promoter : Prof B. Zeelie 2 DECLARATION I, Lancelot Brooks, hereby declare that the above-mentioned treatise is my own work and that it has not previously been submitted for assessment to another University, or for another qualification. ……………………………….. ……………………….. Mr. L.L. Brooks Date 3 ACKNOWLEDGEMENTS To my promoters Dr. Gary Dugmore, and Prof. Ben Zeelie for their invaluable input, help and guidance. To NRF and NMMU for financial assistance To my parents and brothers for their love and support To Peter, Batsho, Unati, and friends in NMMU chemistry research laboratory, thank you guys. To my dearest fiancée, Natasha, a very special thank you for always being there and supporting me. Love you angel. “And we know that all things work together for good to those who love God, to those who are called according to His purpose” -Romans 8:28. 4 TABLE OF CONTENTS DECLARATION……………………………………………………………………. 2 ACKNOWLEDGEMENTS……………………………………………………………. 3 TABLE OF CONTENTS………………………………………………………………. 4 LIST OF FIGURES…………………………………………………………………….. 8 LIST OF TABLES……………………………………………………………………… 9 LIST OF EQUATIONS………………………………………………………………… 11 SUMMARY……………………………………………………………………………… 12 CHAPTER 1…………………………………………………………………………….. 14 INTRODUCTION………………………………………………………………………. 14 1.1. Technology of leather production……………………………………………….. 14 1.2. Synthesis of TCMTB……………………………………………………………… 17 1.3. Bromine……………………………………………………………………………. 20 1.3.1. Overview……………………………………………………………. 20 1.3.2. Applications of bromine compounds…………..…………………. 22 1.3.2.1. Photography……………………………………………… 22 1.3.2.2. -
Assessment of Portable HAZMAT Sensors for First Responders
The author(s) shown below used Federal funds provided by the U.S. Department of Justice and prepared the following final report: Document Title: Assessment of Portable HAZMAT Sensors for First Responders Author(s): Chad Huffman, Ph.D., Lars Ericson, Ph.D. Document No.: 246708 Date Received: May 2014 Award Number: 2010-IJ-CX-K024 This report has not been published by the U.S. Department of Justice. To provide better customer service, NCJRS has made this Federally- funded grant report available electronically. Opinions or points of view expressed are those of the author(s) and do not necessarily reflect the official position or policies of the U.S. Department of Justice. Assessment of Portable HAZMAT Sensors for First Responders DOJ Office of Justice Programs National Institute of Justice Sensor, Surveillance, and Biometric Technologies (SSBT) Center of Excellence (CoE) March 1, 2012 Submitted by ManTech Advanced Systems International 1000 Technology Drive, Suite 3310 Fairmont, West Virginia 26554 Telephone: (304) 368-4120 Fax: (304) 366-8096 Dr. Chad Huffman, Senior Scientist Dr. Lars Ericson, Director UNCLASSIFIED This project was supported by Award No. 2010-IJ-CX-K024, awarded by the National Institute of Justice, Office of Justice Programs, U.S. Department of Justice. The opinions, findings, and conclusions or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect those of the Department of Justice. This document is a research report submitted to the U.S. Department of Justice. This report has not been published by the Department. Opinions or points of view expressed are those of the author(s) and do not necessarily reflect the official position or policies of the U.S. -
Argonne Report.Pdf
CONTENTS NOTATION ........................................................................................................................... xi ABSTRACT ........................................................................................................................... 1 1 INTRODUCTION ........................................................................................................... 5 1.1 Overview of the Emergency Response Guidebook ................................................ 5 1.2 Organization of this Report ..................................................................................... 7 2 GENERAL METHODOLOGY ....................................................................................... 9 2.1 TIH List ................................................................................................................... 10 2.1.1 Background ................................................................................................. 10 2.1.2 Changes in the TIH List for the ERG2012 ................................................. 11 2.2 Shipment and Release Scenarios ............................................................................ 11 2.2.1 Shipment Profiles ........................................................................................ 12 2.2.2 Treatment of Chemical Agents ................................................................... 14 2.3 Generics, Mixtures, and Solutions .......................................................................... 17 2.4 Analysis of Water-Reactive -
Chemical Name Federal P Code CAS Registry Number Acutely
Acutely / Extremely Hazardous Waste List Federal P CAS Registry Acutely / Extremely Chemical Name Code Number Hazardous 4,7-Methano-1H-indene, 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro- P059 76-44-8 Acutely Hazardous 6,9-Methano-2,4,3-benzodioxathiepin, 6,7,8,9,10,10- hexachloro-1,5,5a,6,9,9a-hexahydro-, 3-oxide P050 115-29-7 Acutely Hazardous Methanimidamide, N,N-dimethyl-N'-[2-methyl-4-[[(methylamino)carbonyl]oxy]phenyl]- P197 17702-57-7 Acutely Hazardous 1-(o-Chlorophenyl)thiourea P026 5344-82-1 Acutely Hazardous 1-(o-Chlorophenyl)thiourea 5344-82-1 Extremely Hazardous 1,1,1-Trichloro-2, -bis(p-methoxyphenyl)ethane Extremely Hazardous 1,1a,2,2,3,3a,4,5,5,5a,5b,6-Dodecachlorooctahydro-1,3,4-metheno-1H-cyclobuta (cd) pentalene, Dechlorane Extremely Hazardous 1,1a,3,3a,4,5,5,5a,5b,6-Decachloro--octahydro-1,2,4-metheno-2H-cyclobuta (cd) pentalen-2- one, chlorecone Extremely Hazardous 1,1-Dimethylhydrazine 57-14-7 Extremely Hazardous 1,2,3,4,10,10-Hexachloro-6,7-epoxy-1,4,4,4a,5,6,7,8,8a-octahydro-1,4-endo-endo-5,8- dimethanonaph-thalene Extremely Hazardous 1,2,3-Propanetriol, trinitrate P081 55-63-0 Acutely Hazardous 1,2,3-Propanetriol, trinitrate 55-63-0 Extremely Hazardous 1,2,4,5,6,7,8,8-Octachloro-4,7-methano-3a,4,7,7a-tetra- hydro- indane Extremely Hazardous 1,2-Benzenediol, 4-[1-hydroxy-2-(methylamino)ethyl]- 51-43-4 Extremely Hazardous 1,2-Benzenediol, 4-[1-hydroxy-2-(methylamino)ethyl]-, P042 51-43-4 Acutely Hazardous 1,2-Dibromo-3-chloropropane 96-12-8 Extremely Hazardous 1,2-Propylenimine P067 75-55-8 Acutely Hazardous 1,2-Propylenimine 75-55-8 Extremely Hazardous 1,3,4,5,6,7,8,8-Octachloro-1,3,3a,4,7,7a-hexahydro-4,7-methanoisobenzofuran Extremely Hazardous 1,3-Dithiolane-2-carboxaldehyde, 2,4-dimethyl-, O- [(methylamino)-carbonyl]oxime 26419-73-8 Extremely Hazardous 1,3-Dithiolane-2-carboxaldehyde, 2,4-dimethyl-, O- [(methylamino)-carbonyl]oxime. -
Measurement Technique for the Determination of Photolyzable
JOURNAL OF GEOPHYSICAL RESEARCH, VOL. 102, NO. D13, PAGES 15,999-16,004,JULY 20, 1997 Measurement techniquefor the determination of photolyzable chlorine and bromine in the atmosphere G. A. Impey,P. B. Shepson,• D. R. Hastie,L. A. Bartie• Departmentof Chemistryand Centre for AtmosphericChemistry, York University,Toronto, Ontario, Canada Abstract. A techniquehas been developed to enablemeasurement of photolyzablechlorine and bromineat tracelevels in the troposphere.In thismethod, ambient air is drawnt•ough a cylindricalflow cell, whichis irradiatedwith a Xe arc lamp. In the reactionvessel of the photoactivehalogen detector (PHD), photolyrically active molecules Clp (including C12, HOC1, C1NO,C1NO2, and C1ONO2) and Brp (including Br2, HOBr, BrNO, BrNO2, and BrONO2) are photolyzed,and the halogenatoms produced react with properieto form stablehalogenated products.These products are thensampled and subsequently separated and detected by gas chromatography.The systemis calibratedusing low concentrationmixtures of C12and Br2 in air from commerciallyavailable permeation sources. We obtaineddetection limits of 4 pptv and 9 pptv as Br2 andC12, respectively, for 36 L samples. 1. Introduction (or C12)in the Arctic, largely as a result of the lack of suitable analyticalmethodologies. This paperreports the developmentof The episodicdestruction of groundlevel ozonein the Arctic at a measurementtechnique for the determinationof rapidly sunriseis a phenomenonthat hasbeen observed for many years. photolyzingchlorine (referred to hereas Clp) and bromine (Brp) With the onsetof polar sunrise,ozone levels are often observed speciesat pansper trillion by volume(pptv) mixingratios in the to drop from a backgroundconcentration of •40 ppbv to almost atmosphere.Impey et al. [this issue]discuss the resultsobserved zero on a timescaleof a day or less [Barrie et al., 1988] for from a field studyconducted in the Canadianhigh Arctic at Alert, periodsof 1-10 days. -
The List of Extremely Hazardous Substances)
APPENDIX A (THE LIST OF EXTREMELY HAZARDOUS SUBSTANCES) THRESHOLD REPORTABLE INVENTORY RELEASE QUANTITY QUANTITY CAS NUMBER CHEMICAL NAME (POUNDS) (POUNDS) 75-86-5 ACETONE CYANOHYDRIN 500 10 1752-30-3 ACETONE THIOSEMICARBAZIDE 500/500 1,000 107-02-8 ACROLEIN 500 1 79-06-1 ACRYLAMIDE 500/500 5,000 107-13-1 ACRYLONITRILE 500 100 814-68-6 ACRYLYL CHLORIDE 100 100 111-69-3 ADIPONITRILE 500 1,000 116-06-3 ALDICARB 100/500 1 309-00-2 ALDRIN 500/500 1 107-18-6 ALLYL ALCOHOL 500 100 107-11-9 ALLYLAMINE 500 500 20859-73-8 ALUMINUM PHOSPHIDE 500 100 54-62-6 AMINOPTERIN 500/500 500 78-53-5 AMITON 500 500 3734-97-2 AMITON OXALATE 100/500 100 7664-41-7 AMMONIA 500 100 300-62-9 AMPHETAMINE 500 1,000 62-53-3 ANILINE 500 5,000 88-05-1 ANILINE,2,4,6-TRIMETHYL- 500 500 7783-70-2 ANTIMONY PENTAFLUORIDE 500 500 1397-94-0 ANTIMYCIN A 500/500 1,000 86-88-4 ANTU 500/500 100 1303-28-2 ARSENIC PENTOXIDE 100/500 1 THRESHOLD REPORTABLE INVENTORY RELEASE QUANTITY QUANTITY CAS NUMBER CHEMICAL NAME (POUNDS) (POUNDS) 1327-53-3 ARSENOUS OXIDE 100/500 1 7784-34-1 ARSENOUS TRICHLORIDE 500 1 7784-42-1 ARSINE 100 100 2642-71-9 AZINPHOS-ETHYL 100/500 100 86-50-0 AZINPHOS-METHYL 10/500 1 98-87-3 BENZAL CHLORIDE 500 5,000 98-16-8 BENZENAMINE, 3-(TRIFLUOROMETHYL)- 500 500 100-14-1 BENZENE, 1-(CHLOROMETHYL)-4-NITRO- 500/500 500 98-05-5 BENZENEARSONIC ACID 10/500 10 3615-21-2 BENZIMIDAZOLE, 4,5-DICHLORO-2-(TRI- 500/500 500 FLUOROMETHYL)- 98-07-7 BENZOTRICHLORIDE 100 10 100-44-7 BENZYL CHLORIDE 500 100 140-29-4 BENZYL CYANIDE 500 500 15271-41-7 BICYCLO[2.2.1]HEPTANE-2-CARBONITRILE,5- -
Chapter 6 Industrial Applications of Multicomponent Reactions (Mcrs)
University of Groningen Innovative multicomponent reactions and their use in medicinal chemistry Zarganes Tzitzikas, Tryfon IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2017 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Zarganes Tzitzikas, T. (2017). Innovative multicomponent reactions and their use in medicinal chemistry. University of Groningen. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 24-09-2021 CHAPTER 6 INDUSTRIAL APPLICATIONS OF MULTICOMPONENT REACTIONS (MCRS) Chapter contained in the Rodriguez-Bonne book Stereoselectve Multple Bond-Forming Transformatons in Organic Synthesis 2015 by John Wiley & Sons, Inc. Tryfon Zarganes – Tzitzikas, Ahmad Yazbak, Alexander Dömling Chapter 6 INTRODUCTION Multcomponent reactons (MCRs) can be defned as processes in which three or more reactants introduced simultaneously are combined through covalent bonds to form a single product, regardless of the mechanisms and protocols involved.[1] Many basic MCRs are name reactons, for example, Ugi,[2] Passerini,[3] van Leusen,[4] Strecker,[5] Hantzsch,[6] Biginelli,[7] or one of their many variatons.