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Histopathological Bodies in Oral Pathology 1NJ Naziya, 2P Jayanthi, 3RK Harish, 4R Rathy, 5S Sunil

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Histopathological Bodies in Oral Pathology 1NJ Naziya, 2P Jayanthi, 3RK Harish, 4R Rathy, 5S Sunil OMPJ NJ Naziya et al 10.5005/jp-journals-10037-1114 MINI REVIEW Histopathological Bodies in Oral Pathology 1NJ Naziya, 2P Jayanthi, 3RK Harish, 4R Rathy, 5S Sunil ABSTRACT (A) Infectious diseases: Introduction: Histopathological bodies refer to the cell bodies • Henderson–Peterson bodies that are associated with the name of the scientist who first • Cowdry type I bodies described them. The histopathological bodies are either intra­ • Cowdry type II bodies cellular or extracellular abnormal bodies seen specifically • Negri bodies in certain diseases. These structures appear within the cell • Toto bodies nucleus, the cytoplasm, or in both. (B) Neoplasms: Objectives: This article lists some of the named cell bodies • Wagner–Meissner bodies seen in routine histopathological practice with a brief description • Verocay bodies about their morphology and staining reactions. • Russell bodies Conclusion: Histopathological bodies represent peculiar mor­ • Pustulo-ovoid bodies of Milian phological alterations in a tissue giving rise to a highly specific pattern. The presence of these bodies is often an important • Kamino bodies diagnostic aid in identifying the underlying disease. • Dutcher bodies (C) Autoimmune diseases: Keywords: Cell bodies, Histopathology, Morphology. • Civatte bodies How to cite this article: Naziya NJ, Jayanthi P, Harish RK, • Schaumann bodies Rathy R, Sunil S. Histopathological Bodies in Oral Pathology. Oral Maxillofac Pathol J 2017;8(2):114-117. (D) Blood dyscrasias: • Heinz bodies Source of support: Nil • Howell–Jolly bodies Conflict of interest: None • Fessas bodies (E) Inflammatory lesions: INTRODUCTION • Rushton bodies Histopathological bodies are either intracellular or Histopathological Bodies seen in Physiological extracellular abnormal bodies seen specifically in certain Conditions diseases. These structures appear within the cell nucleus or the cytoplasm or in both, and exhibit characteristic Odland Bodies (Lamellar Body) staining properties. The presence of histopathological Keratinized stratified squamous epithelium exhibits bodies is often an important diagnostic aid in identifying Odland bodies with sizes ranging from 100 to 2,400 nm. the underlying disease.1 They are secretory organelles found in type II pneumo- According to etiopathogenesis, histopathological cytes and keratinocytes. Lamellar bodies are also found bodies can be briefly classified as: in the gastrointestinal tract, tongue papillae, oral epithe- • Histopathologic bodies in physiological conditions lium, and mucosa cells of the stomach.2 The granules • Odland bodies present in lamellar bodies fuse with the cell membrane • Weibel–Palade bodies and release their contents into the extracellular space. • Histopathologic bodies in pathological conditions Lamellar body secretion is abnormal in the epidermis of patients with Netherton syndrome, atherosclerosis, and Niemann–Pick disease.3 1Postgraduate Student, 2Professor, 3Reader, 4,5Professor and Head Weibel–Palade Bodies 1-4Department of Oral and Maxillofacial Pathology, Azeezia College of Dental Sciences & Research, Kollam, Kerala, India Weibel–Palade bodies were initially described by the 4 5Department of Oral and Maxillofacial Pathology, Pushpagiri Swiss anatomist Weibel and Palade. Storage granules College of Dental Sciences, Thiruvalla, Kerala, India of endothelial cells are known as Weibel–Palade bodies. Corresponding Author: P Jayanthi, Professor, Department of Oral They are large cigar-shaped granules. They store and dis- and Maxillofacial Pathology, Azeezia College of Dental Sciences & charge two prime molecules, von Willebrand factor and Research, Kollam, Kerala, India, Phone:+919995117799, e-mail: P-selectin, thereby performing a dual function in inflam- [email protected] mation and hemostasis. Additional Weibel–Palade body 114 OMPJ Histopathological Bodies in Oral Pathology components are interleukin 8, eotaxin-3, endo thelin-1, containing parallel slits observed within the cellular and angiopoietin-2.5 sheets. This peculiar presentation is known as Wagner– Meissner body and is seen in neurofibroma and oral Histopathologic Bodies seen in Pathological lesions of patients with von Recklinghausen’s disease Conditions of skin.11,12 Verocay bodies: Verocay bodies refer to the peculiar Infectious Diseases alignment of nuclei into parallel rows and were first Henderson–Peterson bodies: Henderson–Peterson bodies described in detail by Jose Juan Verocay in 1910 in a are inclusion bodies seen in molluscum contagiosum, benign nerve tumor called schwannoma. Later investiga- a disease caused by Pox group of viruses. These bodies tors defined these bodies as stacked arrangements of elon- are large, ellipsoid, homogeneous intracytoplasmic inclu- gated palisading nuclei alternating with anuclear zones sions seen in the stratum spinosum and stratum corneum containing cell processes. These Verocay bodies are typi- 1 of the infected epithelium. They are made of nuclear and cally found in the more densely packed Antoni A regions cytoplasmic aggregates, usually proteins, and represent of schwannoma, rather than in the loose or microcystic 6,7 the site of viral multiplication. Antoni B areas. Some investigators have identified large Cowdry type I and B bodies: Cowdry type I bodies are amounts of laminin associated with cells participating droplet-like masses of acidophilic material surrounded in formation of Verocay bodies. Lysophosphatidic acid, by clear halos that are seen within the nuclei. The nuclei an extracellular phospholipid that regulates Schwann also exhibit changes like margination of chromatin on the cell adhesion and structure, has been found to induce nuclear membrane. Cowdry type II bodies are similar in cluster formation.13 appearance to type I bodies, but they do not produce any Russell bodies: Russell bodies are eosinophilic, homo- other nuclear changes. Type I bodies are seen in herpes geneous immunoglobulin-containing inclusions usually 1 infection and type II bodies in infection with poliovirus. found in a plasma cell undergoing excessive synthesis Negri bodies: Negri in 1903 discovered the bodies of immunoglobulin. Special stains like fuchsin, periodic contained within the nerve cells of the central nervous acid-Schiff, and Grunwald-Giemsa stain are used to dem- system in cases of rabies. Negri bodies are eosinophilic, onstrate Russell bodies.1 They are named after Russell,14 sharply outlined inclusion bodies found in the cytoplasm a Scottish physician. of certain nerve cells containing the rabies virus. The size Russell body formation appears to indicate cellular of these bodies varies from 0.25 to 21 µm. With the Van indigestion due to a failure to eliminate misfolded or Gieson stain and also with the basic fuchsin modifica- incorrectly assembled proteins. They are frequently seen 8 tion of it, the bodies take a characteristic pink stain. in multiple myeloma, plasmacytoma, Helicobacter pylori Ultrastructural studies have shown that Negri body infection, periapical granuloma, and chronic inflamma- consists of a mass of nucleocapsids surrounded by viral tory granuloma.15 9 particles budding from intracytoplasmic membranes. Pustulo-ovoid Bodies of Milian: These are round eosino- Toto bodies: Toto bodies refer to eosinophilic, homoge- philic inclusions made of coalescing granules surrounded neous masses present in the superficial prickle cell layer by a clear halo.1 These bodies are generated by the gradual of the surface epithelium. These bodies were identified accumulation of granules in the interior of the lysosomes by Toto as dystrophic complexes of acid and neutral and are usually associated with granular cell tumors. mucopolysaccharides with keratin and were mentioned Granular cell tumor can develop on any skin or mucosal 10 as “mucopolysaccharide keratin dystrophy”. Through surface, but occurs predominantly on the tongue.16 11 ultrastructural study, Buchner demonstrated that these Kamino bodies: In 1979, Kamino et al described dull eosinophilic bodies were found extracellularly in the pink globules in the epidermis of 65% of junctional nevi, dilated intercellular spaces. These eosinophilic bodies are 75% of compound nevi, and 25% of intradermal types of commonly found in various oral inflammatory lesions Spitz nevi. Kamino body is a feature that may be helpful like epulis fissuratum, irritation fibromas, pyogenic in the differential diagnosis between nevi and malignant granuloma, peripheral giant cell granuloma, and inflam- melanoma.17 Kamino bodies are eosinophilic bodies with 10 matory hyperplastic gingivitis. scalloped borders and crescent-shaped periphery, which appears as globules or aggregates at the dermal–epider- Neoplasms mal junction.1 Kamino bodies were once believed to have Wagner–Meissner bodies: Some of the benign nerve been degenerated basal cells or melanocytes. The main tumors show a unique histopathological presentation, content of Kamino bodies is found to be type IV and type the presence of oval aggregates of eosinophilic globules VII collagen.18 Oral and Maxillofacial Pathology Journal, July-December 2017;8(2):114-117 115 NJ Naziya et al Dutcher bodies: In 1959, Dutcher and Fahey described Howell–Jolly bodies: Howell-Jolly bodies are small, inclusion bodies that appear to be intranuclear inclu- round inclusions representing nuclear remnants within sions of immunoglobulin protein, which they named the erythrocytes. They are named after William Henry as Dutcher bodies. They are pseudoinclusions formed Howell and Justin Marie Jolly. Normally,
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