Association of Anticholinergic Drug Use with Risk for Late Age-Related Macular Degeneration

Supplementary Online Content

Aldebert G, Faillie J-L, Hillaire-Buys D, et al. Association of anticholinergic drug use with risk for late age-related macular degeneration. JAMA Ophthalmol. Published online May 24, 2018. doi:10.1001/jamaophthalmol.2018.1719

eTable. Anticholinergic Drugs and their Anticholinergic Drug Scale (ADS) Score Considered in This Study

This supplementary material has been provided by the authors to give readers additional information about their work.

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eTable. Anticholinergic Drugs and their Anticholinergic Drug Scale (ADS) Score Considered in This Study

ADS score = 1 ADS score = 2 ADS score = 3

Amantadine Alizapride* Alimémazine* Imipramine Bromocriptine Amoxapine* Amitriptyline Lévomépromazine* Chlordiazépoxide Carbamazépine Atropine Méclozine Clonazépam Cimétidine Bromphéniramine Méquitazine* Codéine Cyproheptadine Chlorphéniramine Oxomémazine* Diazépam Disopyramide Chlorpromazine Oxybutinine Fentanyl Loxapine Clomipramine Piméthixène* Fluoxétine Mépéridine Clozapine Phéniramine* Fluphénazine Métopimazine* Cyamémazine* Prométhazine Fluvoxamine Oxcarbazépine Dexchorphéniramine* Propériciazine* Lopéramide Pimozide Dimenhydrinate Scopolamine Morphine Ranitidine Diphenhydramine Solifénacine* Olanzapine Dosulepine* Toltérodine Oxycodone Doxépine Trihéxyphénidyl Paroxétine Doxylamine* Trimipramine Témazépam Hydroxyzine Triprolidine* Théophylline Tramadol

- Drugs from the Anticholinergic Drug Scale (Carnahan et al. J Clin Pharmacol 2006;46:1481–1486). - We excluded from the scale drugs with score=1 and not listed by Duran et al. (Eur J Clin Pharmacol 2013;69:1485–96) because of potential anti-muscarinic effects in vitro but without clinical anti-muscarinic effects consensually accepted. These excluded drugs were valproic acid, oxazepam, clorazepate, lorazepam, alprazolam, sertraline, nizatidine, famotidine, digoxin, isosorbide, triamterene, rurosemide, chlorthalidone, nifedipine, diltiazem, captopril, prednislone, prednisone, methylprednisolone, triamcinolone, hydrocortisone, gentamycin, dexamethasone, warfarin, dipyridamole, ampicillin, piperacillin, clindamycin, cyclosporin, azathioprine. - We added the drugs with clinical anticholinergic effects marketed in France listed by Laroche et al. (Eur J Clin Pharmacol 2007;63:725–31) and not listed in the ADS. For these drugs, we used the anticholinergic weight attributed by a college of pharmacologists, as in a previous French study (Montastruc et al. Eur J Clin Pharmacol 2014;70:1147–8). These drugs are indicated with stars in the Supplementary Table above.

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