178 (11) J Immunol 2007; 178:6673-7488; ; http://www.jimmunol.org/content/178/11 This information is current as of October 1, 2021. Downloaded from Why The JI? Submit online. • Rapid Reviews! 30 days* from submission to initial decision • No Triage! Every submission reviewed by practicing scientists http://www.jimmunol.org/ • Fast Publication! 4 weeks from acceptance to publication *average Subscription Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription Permissions Submit copyright permission requests at: http://www.aai.org/About/Publications/JI/copyright.html by guest on October 1, 2021 Email Alerts Receive free email-alerts when new articles cite this article. Sign up at: http://jimmunol.org/alerts The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. VOL. 178 Խ NO. 11 Խ June 1, 2007 Խ Pages 6673–7498 IMMUNOLOGY OF TABLE OF CONTENTS 6673 In This Issue Pillars of Immunology 6675 Controlling the Ir Genes Jeremy M. Boss 6677 Pillars Article: Complementation Cloning of an MHC Class II Transactivator Mutated in Hereditary MHC Class II Deficiency (or Bare Lymphocyte Syndrome). Cell 1993. 75: 135–146. Viktor Steimle, Luc A. Otten, Madeleine Zufferey, and Bernard Mach Downloaded from Brief Reviews 6689 Telomerase in T Lymphocytes: Use It and Lose It? OURNAL Arne N. Akbar and Milica Vukmanovic-Stejic J Cutting Edge http://www.jimmunol.org/ THE ϩ 6695 Cutting Edge: CNS CD11c Cells from Mice with Encephalomyelitis Polarize Th17 cells and Support ϩ ϩ CD25 CD4 T cell-Mediated Immunosuppression, Suggesting Dual Roles in the Disease Process Pratima Deshpande, Irah L. King, and Benjamin M. Segal 6700 Cutting Edge: Small Molecule CD40 Ligand Mimetics Promote Control of Parasitemia and Enhance T Cells Producing IFN-␥ during Experimental Trypanosoma cruzi Infection Mohammed Habib, Magali Noval Rivas, Mustapha Chamekh, Se´bastien Wieckowski, Weimin Sun, Alberto Bianco, Nathalie Trouche, Olivier Chaloin, He´le`ne Dumortier, Michel Goldman, Gilles Guichard, Sylvie Fournel, by guest on October 1, 2021 and Bernard Vray 6705 Cutting Edge: Involvement of the Type I IFN Production and Signaling Pathway in Lipopolysaccharide- Induced IL-10 Production Elmer Y. Chang, Beichu Guo, Sean E. Doyle, and Genhong Cheng 6710 Cutting Edge: Cross-Regulation by TLR4 and T cell Ig Mucin-3 Determines Sex Differences in Inflammatory Heart Disease Sylvia Frisancho-Kiss, Sarah E. Davis, Jennifer F. Nyland, J. Augusto Frisancho, Daniela Cihakova, Masheka A. Barrett, Noel R. Rose, and DeLisa Fairweather On the cover: Confocal microscopy of human airway smooth muscle cells in primary culture incubated with an antibody to glucocorticoid receptor (GR) showing nuclear translocation of GR after exposure to dexamethasone. Staining of nuclei with DAPI is in blue and positive GR staining is shown with Rhodamine red. Nuclei are now stained red as in cytoplasm. Issa, R., S. Xie, N. Khorasani, M. Sukkar, I. M. Adcock, K.-Y. Lee, and K. F. Chung. 2007. Corticosteroid inhibition of growth-related oncogene protein-␣ via mitogen-activated kinase phosphatase-1 in airway smooth muscle cells. J. Immunol. 178: 7366–7375. The Journal of Immunology (ISSN 0022-1767) is published twice each month by The American Association of Immunologists, Inc., 9650 Rockville Pike, Bethesda, MD 20814-3994. Subscription term: New subscriptions and renewals begin January 1 and expire one year later (see http://www.jimmunol.org/subscriptions for prices and details). A special rate is available to members of The American Association of Immunologists, Inc. (see http://www.aai.org/membership). Periodicals postage paid at Bethesda, MD 20814-3998, and at additional mailing offices. Country of origin U.S.A. Printed on acid-free recyclable paper. Postmaster: Send address changes to The Journal of Immunology, Subscription Department, Room L-3407A, 9650 Rockville Pike, Bethesda, MD 20814-3998. Copyright © 2007 by The American Association of Immunologists, Inc. 6715 Cutting Edge: TLR2 Directly Triggers Th1 Effector Functions Takayuki Imanishi, Hiromitsu Hara, Shinobu Suzuki, Nobutaka Suzuki, Shizuo Akira, and Takashi Saito ϩ 6720 Cutting Edge: Direct Action of Thymic Stromal Lymphopoietin on Activated Human CD4 T Cells Irina Rochman, Norihiko Watanabe, Kazuhiko Arima, Yong-Jun Liu, and Warren J. Leonard ϩ Ϫ Ϫ 6725 Cutting Edge: Regulatory T Cells Induce CD4 CD25 Foxp3 T Cells or Are Self-Induced to Become Th17 Cells in the Absence of Exogenous TGF-␤ LiLi Xu, Atsushi Kitani, Ivan Fuss, and Warren Strober 6730 Cutting Edge: Th17 and Regulatory T Cell Dynamics and the Regulation by IL-2 in the Tumor Microenvironment Ilona Kryczek, Shuang Wei, Linhua Zou, Saleh Altuwaijri, Wojciech Szeliga, Jay Kolls, Alfred Chang, and Weiping Zou Cellular Immunology and Immune Regulation 6735 An Essential Role for TNF in Modulating Thresholds for Survival, Activation, and Tolerance of ϩ CD8 T Cells Ioannis Chatzidakis, Georgia Fousteri, Debbie Tsoukatou, George Kollias, and Clio Mamalaki 6746 Normal Hemopoiesis and Lymphopoiesis in the Combined Absence of Numb and Numblike Downloaded from Anne Wilson, Denis-Luc Ardiet, Catherine Saner, Nathalie Vilain, Friedrich Beermann, Michel Aguet, H. Robson MacDonald, and Olav Zilian 6752 Signal 3 Availability Limits the CD8 T Cell Response to a Solid Tumor Julie M. Curtsinger, Michael Y. Gerner, Debra C. Lins, and Matthew F. Mescher http://www.jimmunol.org/ 6761 Comparative Prime-Boost Vaccinations Using Semliki Forest Virus, Adenovirus, and ALVAC Vectors Demonstrate Differences in the Generation of a Protective Central Memory CTL Response against the P815 Tumor Tanja I. Na¨slund, Catherine Uyttenhove, Eva K. L. Nordstro¨m, Didier Colau, Guy Warnier, Mikael Jondal, Benoıˆt J. Van den Eynde, and Peter Liljestro¨m 6770 Lack of Essential Role of NF-␬B p50, RelA, and cRel Subunits in Virus-Induced Type 1 IFN Expression Xingyu Wang, Sofia Hussain, Emilie-Jeanne Wang, Xiuyan Wang, Ming O. Li, Adolfo Garcı´a-Sastre, and Amer A. Beg by guest on October 1, 2021 6777 Distinct Roles of Different NF-␬B Subunits in Regulating Inflammatory and T Cell Stimulatory Gene Expression in Dendritic Cells Junmei Wang, Xingyu Wang, Sofia Hussain, Ye Zheng, Shomyseh Sanjabi, Fatah Ouaaz, and Amer A. Beg 6789 Detection and Long-Term In Vivo Monitoring of Individual Tumor-Specific T Cell Clones in Patients with Metastatic Melanoma Jaroslav Michalek, Ivo Kocak, Vuk Fait, Jan Zaloudik, and Roman Hajek 6796 Redundant Role for Early Growth Response Transcriptional Regulators in Thymocyte Differentiation and Survival John H. Carter, Juliet M. Lefebvre, David L. Wiest, and Warren G. Tourtellotte 6806 Th17 Augmentation in OTII TCR Plus T Cell-Selective Type 1 Sphingosine 1-Phosphate Receptor Double Transgenic Mice Mei-Chuan Huang, Susan R. Watson, Jia-Jun Liao, and Edward J. Goetzl ϩ 6814 Vaccinia Virus-Specific CD4 T Cell Responses Target a Set of Antigens Largely Distinct from Those ϩ Targeted by CD8 T Cell Responses Magdalini Moutaftsi, Huynh-Hoa Bui, Bjoern Peters, John Sidney, Shahram Salek-Ardakani, Carla Oseroff, Valerie Pasquetto, Shane Crotty, Michael Croft, Elliot J. Lefkowitz, Howard Grey, and Alessandro Sette 6821 Human CD5 Protects Circulating Tumor Antigen-Specific CTL from Tumor-Mediated Activation- Induced Cell Death Grzegorz Friedlein, Faten El Hage, Isabelle Vergnon, Catherine Richon, Patrick Saulnier, Yann Le´cluse, Anne Caignard, Laurence Boumsell, Georges Bismuth, Salem Chouaib, and Fathia Mami-Chouaib ␣ ␤ 6828 Regulation of Cell Adhesion by Affinity and Conformational Unbending of 4 1 Integrin Alexandre Chigaev, Anna Waller, Gordon J. Zwartz, Tione Buranda, and Larry A. Sklar ϩ ϩ 6840 CD4 CD25 T Regulatory Cells Dominate Multiple Immune Evasion Mechanisms in Early but Not Late Phases of Tumor Development in a B Cell Lymphoma Model Kutlu G. Elpek, Chantale Lacelle, Narendra P. Singh, Esma S. Yolcu, and Haval Shirwan ϩ 6849 Induction of Tolerance in CD8 T Cells to a Transgenic Autoantigen Expressed in the Liver Does Not Require Cross-Presentation Junko Morimoto, Xiaoxio Tan, Ryan M. Teague, Claes O¨ hle´n, and Philip D. Greenberg Ϫ ϩ 6861 CD103 and CD103 Bronchial Lymph Node Dendritic Cells Are Specialized in Presenting and Cross- ϩ ϩ Presenting Innocuous Antigen to CD4 and CD8 T Cells Maria-Luisa del Rio, Jose-Ignacio Rodriguez-Barbosa, Elisabeth Kremmer, and Reinhold Fo¨rster 6867 Tumor Exosomes Inhibit Differentiation of Bone Marrow Dendritic Cells Shaohua Yu, Cunren Liu, Kaihong Su, Jianhua Wang, Yuelong Liu, Liming Zhang, Chuanyu Li, Yingzi Cong, Robert Kimberly, William E. Grizzle, Carla Falkson, and Huang-Ge Zhang 6876 Murine Dendritic Cell Type I IFN Production Induced by Human IgG-RNA Immune Complexes Is IFN Regulatory Factor (IRF)5 and IRF7 Dependent and Is Required for IL-6 Production Kei Yasuda, Christophe Richez, Joseph W. Maciaszek, Neerja Agrawal, Shizuo Akira, Ann Marshak-Rothstein, and Ian R. Rifkin Downloaded from 6886 Type 2 Diabetes Impairs Insulin Receptor Substrate-2-Mediated Phosphatidylinositol 3-Kinase Activity in Primary Macrophages to Induce a State of Cytokine Resistance to IL-4 in Association with Overexpression of Suppressor of Cytokine Signaling-3 Jason C. O’Connor, Christina L. Sherry, Christopher B. Guest, and Gregory G. Freund 6894 The CD28/CTLA-4-B7 Signaling Pathway Is Involved in Both Allergic Sensitization and Tolerance http://www.jimmunol.org/