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4/23/2015 1 •Psychedelics Or Hallucinogens
4/23/2015 Hallucinogens •Psychedelics or This “classic” hallucinogen column The 2 groups below are quite different produce similar effects From the classic hallucinogens Hallucinogens Drugs Stimulating 5HT Receptors Drugs BLOCKING ACH Receptors • aka “psychotomimetics” LSD Nightshade(Datura) Psilocybin Mushrooms Jimsonweed Morning Glory Seeds Atropine Dimethyltryptamine Scopolamine What do the very mixed group of hallucinogens found around the world share in common? •Drugs Resembling NE Drugs BLOCKING Glutamate Receptors •Peyote cactus Phencyclidine (PCP) •Mescaline Ketamine All contain something that resembles a •Methylated amphetamines like MDMA High dose dextromethorphan •Nutmeg neurotransmitter •New synthetic variations (“bath salts”) •5HT-Like Hallucinogens •LSD History • Serotonin • created by Albert Hofmann for Sandoz Pharmaceuticals LSD • was studying vasoconstriction produced by ergot alkaloids LSD • initial exposure was accidental absorption thru skin • so potent ED is in millionths of a gram (25-250 micrograms) & must be delivered on something else (sugar cube, gelatin square, paper) Psilocybin Activate 5HT2 receptors , especially in prefrontal cortex and limbic areas, but is not readily metabolized •Characteristics of LSD & Other “Typical” •Common Effects Hallucinogens • Sensory distortions (color, size, shape, movement), • Autonomic (mostly sympathetic) changes occur first constantly changing (relatively mild) • Vivid closed eye imagery • Sensory/perceptual changes follow • Synesthesia (crossing of senses – e.g. hearing music -
Protabase Record Display Datura Stramonium L
Protabase Record display www.prota.org Datura stramonium L. Protologue Sp. pl. 1: 179 (1753). Family Solanaceae Chromosome number 2n = 24 Vernacular names Thorn apple, green thorn apple, Jimson weed, Jamestown weed, devil’s apple, devil’s trumpet, stramonium (En). Pomme épineuse, stramoine, datura, feuille du diable, herbe du diable (Fr). Figueira do inferno, pomo espinhoso, erva dos bruxos, palha verde, estramonio (Po). Muranha (Sw). Origin and geographic distribution Datura stramonium is native to the Americas and has been introduced in many tropical, subtropical and even temperate regions. It is a naturalized weed in many African countries, but is probably seriously under-reported. Uses Datura stramonium and Datura metel L. have largely similar medicinal uses throughout the world. The most widely known use of Datura stramonium and of other Datura species is for relieving asthma, cough, tuberculosis and bronchitis by smoking the dried leaves, roots or flowers. ‘Asthma cigarettes’ have been shown to be very effective in some cases, but in other cases they had little or no effect. Cigarettes made with the leaves are also used to treat Parkinson’s disease. A decoction or infusion of leaves is given as a sedative to mental and schizophrenic patients. The leaves are applied as a dressing to cure rheumatic pain, swellings, wounds, gout, burns, ingrown toe-nails, fungal infections, tumours and ulcers. Dried pulverized leaves are dusted on wounds or applied after mixing the powder with fat or Vaseline. In DR Congo pounded fresh root and fresh leaves are soaked in water and the liquid is given in enema as an abortifacient. -
Chemical Compounds, Pharmacological and Toxicological Activity of Brugmansia Suaveolens: a Review
plants Review Chemical Compounds, Pharmacological and Toxicological Activity of Brugmansia suaveolens: A Review Vera L. Petricevich 1 , David Osvaldo Salinas-Sánchez 2, Dante Avilés-Montes 3, Cesar Sotelo-Leyva 4 and Rodolfo Abarca-Vargas 1,* 1 Faculty of Medicine, Autonomous University of the State of Morelos (UAEM), Street: Leñeros, esquina Iztaccíhuatl s/n. Col. Volcanes, Cuernavaca 62350, Morelos, Mexico; [email protected] 2 Biodiversity and Conservation Research Center, Autonomous University of the State of Morelos (UAEM), Av. Universidad 1001, Col. Chamilpa, Cuernavaca 62209, Morelos, Mexico; [email protected] 3 Faculty of Biological Science, Autonomous University of the State of Morelos (UAEM), Av. Universidad 1001, Col. Chamilpa, Cuernavaca 62209, Morelos, Mexico; [email protected] 4 Faculty of Chemistry-Biological Sciences, Autonomous University of Guerrero Av. Lázaro Cárdenas s/n, South University City, Chilpancingo 39000, Guerrero, Mexico; [email protected] * Correspondence: [email protected]; Tel.: +52-777-361-2155 Received: 30 July 2020; Accepted: 3 September 2020; Published: 8 September 2020 Abstract: This study investigates updated information in different search engines on the distribution, phytochemistry, pharmacology, and toxicology of Brugmansia suaveolens (Solanaceae) using the extracts or chemical compounds at present. This plant has been used in traditional medicine in different cultures as a hallucinatory, analgesic, aphrodisiac, nematicide, sleep inducer, and muscle relaxant, as well as a treatment for rheumatism, asthma, and inflammation. The flowers, fruits, stems, and roots of the plant are used, and different chemical compounds have been identified, such as alkaloids, volatile compounds (mainly terpenes), coumarins, flavonoids, steroids, and hydrocarbons. The concentration of the different compounds varies according to the biotic and abiotic factors to which the plant is exposed. -
"National List of Vascular Plant Species That Occur in Wetlands: 1996 National Summary."
Intro 1996 National List of Vascular Plant Species That Occur in Wetlands The Fish and Wildlife Service has prepared a National List of Vascular Plant Species That Occur in Wetlands: 1996 National Summary (1996 National List). The 1996 National List is a draft revision of the National List of Plant Species That Occur in Wetlands: 1988 National Summary (Reed 1988) (1988 National List). The 1996 National List is provided to encourage additional public review and comments on the draft regional wetland indicator assignments. The 1996 National List reflects a significant amount of new information that has become available since 1988 on the wetland affinity of vascular plants. This new information has resulted from the extensive use of the 1988 National List in the field by individuals involved in wetland and other resource inventories, wetland identification and delineation, and wetland research. Interim Regional Interagency Review Panel (Regional Panel) changes in indicator status as well as additions and deletions to the 1988 National List were documented in Regional supplements. The National List was originally developed as an appendix to the Classification of Wetlands and Deepwater Habitats of the United States (Cowardin et al.1979) to aid in the consistent application of this classification system for wetlands in the field.. The 1996 National List also was developed to aid in determining the presence of hydrophytic vegetation in the Clean Water Act Section 404 wetland regulatory program and in the implementation of the swampbuster provisions of the Food Security Act. While not required by law or regulation, the Fish and Wildlife Service is making the 1996 National List available for review and comment. -
From Witch Doctor to Modern Medicine: Searching the American Tropics for Potentially New Medicinal Plants
From Witch Doctor to Modern Medicine: Searching the American Tropics for Potentially New Medicinal Plants "And as there are discouvered new Regions, new King- doms and new Provinces by our Spaniards, so they have brought unto us new Medicines, and newe Remedies, wherewith they do cure many infirmities, which, if we did lacke them, would be incurible, and without any remedie ... for which cause I did pretend to treate, and to write of all things that they bring from our Indias, apperteyning to the Arte and Use of Medicine, and the remedie of hurtes and diseases that we doo suffer and endure ...". Nicholas Monardes [transl. John Frampton] "Joyfull Newes out of the New-found World" (1596) The search for potential new medicines from the Plant King- dom is not new. It has been carried on since man first became aware ot the variety ot ettects that plants had on his mind and body. It is still under way. But we now have many ad- vantages over man in all prior ages. We have millennia of experience behind us; a deeper understanding of what plants are and how they live; an intensity of modern technology to help us; and, what is more important than all of the other advantages, a determination to probe into the still virgin vegetal world for active compounds of promise for man’s existence. Today we follow several discreet paths in our search for "new" medicinal plants. Some modern programs - ambitious, technologically com- plex and potentially promising - have emphasized the random or semi-random screening of plants from all parts of the world for new organic compounds. -
Nightshade”—A Hierarchical Classification Approach to T Identification of Hallucinogenic Solanaceae Spp
Talanta 204 (2019) 739–746 Contents lists available at ScienceDirect Talanta journal homepage: www.elsevier.com/locate/talanta Call it a “nightshade”—A hierarchical classification approach to T identification of hallucinogenic Solanaceae spp. using DART-HRMS-derived chemical signatures ∗ Samira Beyramysoltan, Nana-Hawwa Abdul-Rahman, Rabi A. Musah Department of Chemistry, State University of New York at Albany, 1400 Washington Ave, Albany, NY, 12222, USA ARTICLE INFO ABSTRACT Keywords: Plants that produce atropine and scopolamine fall under several genera within the nightshade family. Both Hierarchical classification atropine and scopolamine are used clinically, but they are also important in a forensics context because they are Psychoactive plants abused recreationally for their psychoactive properties. The accurate species attribution of these plants, which Seed species identifiction are related taxonomically, and which all contain the same characteristic biomarkers, is a challenging problem in Metabolome profiling both forensics and horticulture, as the plants are not only mind-altering, but are also important in landscaping as Direct analysis in real time-mass spectrometry ornamentals. Ambient ionization mass spectrometry in combination with a hierarchical classification workflow Chemometrics is shown to enable species identification of these plants. The hierarchical classification simplifies the classifi- cation problem to primarily consider the subset of models that account for the hierarchy taxonomy, instead of having it be based on discrimination between species using a single flat classification model. Accordingly, the seeds of 24 nightshade plant species spanning 5 genera (i.e. Atropa, Brugmansia, Datura, Hyocyamus and Mandragora), were analyzed by direct analysis in real time-high resolution mass spectrometry (DART-HRMS) with minimal sample preparation required. -
Ketamine Psychedelic Psychotherapy
KETAMINE PSYCHEDELIC PSYCHOTHERAPY EVGENY KRUPITSKY AND ELI KOLP INTRODUCTION Ketamine hydrochloride is a general anesthetic which has been used for noncon- ventional applications in substance abuse rehabilitation because of its psychedelic properties. This chapter summarizes the results of the research on KPP (ketamine psychedelic psychotherapy), principally with alcoholics and heroin addicts. Mechanisms underlying the effects of hallucinogen-assisted psychotherapy are addressed. Research illustrates how the temporary but effective anti-addictive benefits for a short period of time can be extended for longer periods of time to improve overall long-term adjustment and level of functioning. Ketamine hydrochloride, a prescription drug used for general anesthesia, induces profound psychedelic experiences when administered in sub-anesthetic .doses. Ketamine was originally synthesized in 1962 by the American chemist Calvin Stevens, and in 1966 Parke-Davis patented it for use as an anesthetic in humans. Ketamine became the most widely used anesthetic during the Vietnam War when American anesthesiologists and surgeons became familiar with the agent. In 1970, the U.S. Food and Drug Administration approved the use of ketamine with children, adults, and the elderly. Since that time, ketamine has been widely used in hospitals and for office procedures because of its large margin of safety, rapid onset, and short duration of action. More than 7,000 68 TREATTNG SUBSTANCE ABUSE published reports describe ketamine's high level of effectiveness and its biologi- cal safety (Shapiro et al. 1972; Reich and Silvay 1989; Ross and Fochtman 1995; Dachs and Innes 1997; Bauman et al. 1999; Ersek 2004). Clinical studies have detected no long-term impairment of behavior or personality functioning as a result of ketamine use (Siegal 1978). -
(Antimuscarinic) Drugs?
© July - August 2018 How well do you know your anticholinergic (antimuscarinic) drugs? nticholinergic drugs, prescribed for a variety of clini- Acal conditions, are amongst the most frequently used prescription drugs in BC (Table 1). Also referred to as “an- timuscarinics,” such drugs specifically block muscarinic receptors for acetylcholine (ACh).1 Muscarinic ACh recep- tors are important in the parasympathetic nervous system that governs heart rate, exocrine glands, smooth muscles, clude drugs whose active metabolites are potent- as well as brain function. In contrast, nicotinic ACh recep- ly antimuscarinic,5 or which often cause typical tors stimulate contraction of striated muscles. This Letter is AC adverse effects such as dry mouth or urinary intended to remind clinicians of commonly used drugs that retention.6 People taking antihistamines, antide- have anticholinergic (AC), or technically, antimuscarinic pressants, antipsychotics, opioids, antimuscarinic properties, and of their potential adverse effects. inhalers, or many other drugs need to know that Beneficial and harmful effects of anticholinergic drugs have blockade of ACh receptors can cause bothersome been known for centuries. In Homer’s Odyssey, the nymph or even dangerous adverse effects (Table 3). pharmacologist Circe utilized central effects of atropinics Subtle and not-so-subtle toxicity in the common plant jimson weed (Datura stramonium) to cause delusions in the crew of Odysseus. Believing they Students often learn the adverse effects of anticho- had been turned into pigs, they could be herded.2 linergics from a mnemonic, e.g.: “Blind as a bat, Sometimes a drug is recommended specifically for its an- mad as a hatter, red as a beet, hot as a hare, dry as ticholinergic potency. -
(DMT), Harmine, Harmaline and Tetrahydroharmine: Clinical and Forensic Impact
pharmaceuticals Review Toxicokinetics and Toxicodynamics of Ayahuasca Alkaloids N,N-Dimethyltryptamine (DMT), Harmine, Harmaline and Tetrahydroharmine: Clinical and Forensic Impact Andreia Machado Brito-da-Costa 1 , Diana Dias-da-Silva 1,2,* , Nelson G. M. Gomes 1,3 , Ricardo Jorge Dinis-Oliveira 1,2,4,* and Áurea Madureira-Carvalho 1,3 1 Department of Sciences, IINFACTS-Institute of Research and Advanced Training in Health Sciences and Technologies, University Institute of Health Sciences (IUCS), CESPU, CRL, 4585-116 Gandra, Portugal; [email protected] (A.M.B.-d.-C.); ngomes@ff.up.pt (N.G.M.G.); [email protected] (Á.M.-C.) 2 UCIBIO-REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal 3 LAQV-REQUIMTE, Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal 4 Department of Public Health and Forensic Sciences, and Medical Education, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal * Correspondence: [email protected] (D.D.-d.-S.); [email protected] (R.J.D.-O.); Tel.: +351-224-157-216 (R.J.D.-O.) Received: 21 September 2020; Accepted: 20 October 2020; Published: 23 October 2020 Abstract: Ayahuasca is a hallucinogenic botanical beverage originally used by indigenous Amazonian tribes in religious ceremonies and therapeutic practices. While ethnobotanical surveys still indicate its spiritual and medicinal uses, consumption of ayahuasca has been progressively related with a recreational purpose, particularly in Western societies. The ayahuasca aqueous concoction is typically prepared from the leaves of the N,N-dimethyltryptamine (DMT)-containing Psychotria viridis, and the stem and bark of Banisteriopsis caapi, the plant source of harmala alkaloids. -
Fall TNP Herbals.Pptx
8/18/14 Introduc?on to Objecves Herbal Medicine ● Discuss history and role of psychedelic herbs Part II: Psychedelics, in medicine and illness. Legal Highs, and ● List herbs used as emerging legal and illicit Herbal Poisons drugs of abuse. ● Associate main plant and fungal families with Jason Schoneman RN, MS, AGCNS-BC representave poisonous compounds. The University of Texas at Aus?n ● Discuss clinical management of main toxic Schultes et al., 1992 compounds. Psychedelics Sacraments: spiritual tools or sacred medicine by non-Western cultures vs. Dangerous drugs of abuse vs. Research and clinical tools for mental and physical http://waynesword.palomar.edu/ww0703.htm disorders History History ● Shamanic divinaon ○ S;mulus for spirituality/religion http://orderofthesacredspiral.blogspot.com/2012/06/t- mckenna-on-psilocybin.html http://www.cosmicelk.net/Chukchidirections.htm 1 8/18/14 History History http://www.10zenmonkeys.com/2007/01/10/hallucinogenic- weapons-the-other-chemical-warfare/ http://rebloggy.com/post/love-music-hippie-psychedelic- woodstock http://fineartamerica.com/featured/misterio-profundo-pablo- amaringo.html History ● Psychotherapy ○ 20th century: un;l 1971 ● Recreaonal ○ S;mulus of U.S. cultural revolu;on http://qsciences.digi-info-broker.com http://www.uspharmacist.com/content/d/feature/c/38031/ http://en.wikipedia.org/nervous_system 2 8/18/14 Main Groups Main Groups Tryptamines LSD, Psilocybin, DMT, Ibogaine Other Ayahuasca, Fly agaric Phenethylamines MDMA, Mescaline, Myristicin Pseudo-hallucinogen Cannabis Dissociative -
A Família Solanaceae Juss. No Município De Vitória Da Conquista
Paubrasilia Artigo Original doi: 10.33447/paubrasilia.2021.e0049 2021;4:e0049 A família Solanaceae Juss. no município de Vitória da Conquista, Bahia, Brasil The family Solanaceae Juss. in the municipality of Vitória da Conquista, Bahia, Brazil Jerlane Nascimento Moura1 & Claudenir Simões Caires 1 1. Universidade Estadual do Sudoeste Resumo da Bahia, Departamento de Ciências Naturais, Vitória da Conquista, Bahia, Brasil Solanaceae é uma das maiores famílias de plantas vasculares, com 100 gêneros e ca. de 2.500 espécies, com distribuição subcosmopolita e maior diversidade na região Neotropical. Este trabalho realizou um levantamento florístico das espécies de Palavras-chave Solanales. Taxonomia. Florística. Solanaceae no município de Vitória da Conquista, Bahia, em área ecotonal entre Nordeste. Caatinga e Mata Atlântica. Foram realizadas coletas semanais de agosto/2019 a março/2020, totalizando 30 espécimes, depositados nos herbários HUESBVC e HVC. Keywords Solanales. Taxonomy. Floristics. Foram registradas 19 espécies, distribuídas em nove gêneros: Brunfelsia (2 spp.), Northeast. Capsicum (1 sp.), Cestrum (1 sp.), Datura (1 sp.), Iochroma (1 sp.) Nicandra (1 sp.), Nicotiana (1 sp.), Physalis (1 sp.) e Solanum (10 spp.). Dentre as espécies coletadas, cinco são endêmicas para o Brasil e 11 foram novos registros para o município. Nossos resultados demonstram que Solanaceae é uma família de elevada riqueza de espécies no município, contribuindo para o conhecimento da flora local. Abstract Solanaceae is one of the largest families of vascular plants, with 100 genera and ca. 2,500 species, with subcosmopolitan distribution and greater diversity in the Neotropical region. This work carried out a floristic survey of Solanaceae species in the municipality of Vitória da Conquista, Bahia, in an ecotonal area between Caatinga and Atlantic Forest. -
HANDBOOK of Medicinal Herbs SECOND EDITION
HANDBOOK OF Medicinal Herbs SECOND EDITION 1284_frame_FM Page 2 Thursday, May 23, 2002 10:53 AM HANDBOOK OF Medicinal Herbs SECOND EDITION James A. Duke with Mary Jo Bogenschutz-Godwin Judi duCellier Peggy-Ann K. Duke CRC PRESS Boca Raton London New York Washington, D.C. Peggy-Ann K. Duke has the copyright to all black and white line and color illustrations. The author would like to express thanks to Nature’s Herbs for the color slides presented in the book. Library of Congress Cataloging-in-Publication Data Duke, James A., 1929- Handbook of medicinal herbs / James A. Duke, with Mary Jo Bogenschutz-Godwin, Judi duCellier, Peggy-Ann K. Duke.-- 2nd ed. p. cm. Previously published: CRC handbook of medicinal herbs. Includes bibliographical references and index. ISBN 0-8493-1284-1 (alk. paper) 1. Medicinal plants. 2. Herbs. 3. Herbals. 4. Traditional medicine. 5. Material medica, Vegetable. I. Duke, James A., 1929- CRC handbook of medicinal herbs. II. Title. [DNLM: 1. Medicine, Herbal. 2. Plants, Medicinal.] QK99.A1 D83 2002 615′.321--dc21 2002017548 This book contains information obtained from authentic and highly regarded sources. Reprinted material is quoted with permission, and sources are indicated. A wide variety of references are listed. Reasonable efforts have been made to publish reliable data and information, but the author and the publisher cannot assume responsibility for the validity of all materials or for the consequences of their use. Neither this book nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, microfilming, and recording, or by any information storage or retrieval system, without prior permission in writing from the publisher.