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Retroviruses Retroviruses Session 1 EVOLUTION AND ENDOGENOUS RETROVIRUSES MONDAY 5/19/2014, 7:30 PM S. Goff / H. Levin Presentation of the Ute Von Schwedler Prize for Retrovirology to Suzannah J. Rinh # lname Title Talk Length 1 Rihn Uneven mutational robustness of HIV-1 integrase 10 2 Etienne Hominid restriction factors and their evolution influence host susceptibility to circulating 10 lentiviruses 3 Blanco Melo The evolutionary origins of the HIV-1 restriction factor, tetherin 10 4 Greenberg ZNF91 and ZNF93 evolved to restrict SVA and L1 mobile elements in ape genomes 10 5 Metzger Amplification of the steamer retrotransposon in clam leukemia 10 6 Blomberg piRNA sequences are common in HERVs—An antiretroviral restriction mechanism? 10 7 Lim Discovery of novel lemur retroviruses 10 8 Diehl Rise and fall of an ancient retroviral lineage revealed in the genomes of modern mammals 10 9 Williams Mining deep sequencing data for novel HERVs 10 10 Mulder HIV-1 interaction with HERV-K (HML-2) envelopes derived from human primary lymphocytes 10 11 Robinson Reconstructing the cell-entry pathway of HERV-K 10 12 Battini Identification of a receptor for FeLV-D and its endogenous relatives 10 Session 2 ENTRY TUESDAY 5/20/2014, 9:00 AM R. Swanstrom / G. Melikian # lname Title Talk Length 13 Jolly The retromer complex interacts with HIV-1 envelope glycoprotein and regulates intracellular 10 trafficking 14 Munro Conformational dynamics of single HIV-1 Env trimers on the surface of native virions 10 15 Pham CD4 receptor-engagement induces structural rearrangement of HIV 10 16 Herold Comparative analysis of HIV-1 entry at the plasma membrane and from endosomes 10 17 Melikian Visualization of single retrovirus entry sites in cells expressing alternatively spliced receptor 10 isoforms 18 Marin Distinct requirements for pore dilation upon HIV-cell and virus-mediated cell-cell fusion 10 19 Gardner A CCR5-mimetic sulfopeptide converts CD4-Ig to an exceptionally broad and potent inhibitor of 10 HIV-1 entry 20 Hain ITK plays a central role in integrating signaling pathways required for HIV-1 - T-cell fusion 10 Page 1 of 14 21 Symeonides Syncytia revisited—HIV-infected T lymphocytes can form small, mobile syncytia that transfer virus 10 at sites of transient cell-cell contact + 22 Sewald CD169 macrophages mediate MLV trans-infection of B-1 cells in 10 vivo 23 Menager Mechanisms of dendritic cell-mediated transfer of HIV-1 to CD4+ T lymphocytes 10 24 Joseph HIV-1 macrophage tropism is a distinct Env phenotype that includes the ability to use low levels of 10 CD4 for entry and is a relatively rare phenotype among all virus isolates Session 3 POST-ENTRY I TUESDAY 5/20/2014, 2:00 PM Z. Ambrose / S. Ross # lname Title Talk Length 25 Olson SAXS analysis reveals structural model of the RT initiation complex and conservation of tRNA 10 structural mimicry in the HIV-1 5´UTR 26 Takeuchi AMPK-RPK is an essential host factor for optimal HIV-1 capsid disassembly to promote HIV-1 10 cDNA synthesis in human cells 27 Hulme Early steps of reverse transcription facilitate HIV-1 uncoating 10 28 Peng Quantitative microscopic analysis of functional HIV post-entry complexes 10 29 Ambrose Visualizing HIV-1 uncoating and nuclear entry by confocal and super resolution 10 30 Di Nunzio New insights in the role of nuclear pore basket nucleoporins in chromatin remodelling and HIV 10 integration 31 Stavrou MLV reverse-transcribed DNA induces innate immune responses that limit virus infection in 10 vivo 32 Cimarelli The susceptibility to Vpx and nucleosides during the early phases of myeloid cells infection are 10 determined by distinct viral determinants in the HIV-1 and HIV-2/SIVSM lineages 33 Rasaiyaah Cloaking of lentiviral replication by CPSF6 and cyclophilins in human monocyte derived 10 macrophages 34 Case The HIV-1 core shields viral DNA from the cGAS cytosolic sensing pathway 10 35 Maelfait Transfer of antiviral immunity by incorporation of the secondary messenger cGAMP into HIV-1 10 virions. 36 Towers TRIM5α constructs mixed-linkage ubiquitination to recruit the proteasome and simultaneously 10 trigger innate signaling KEYNOTE SPEAKER I TUESDAY 5/20/2014, 7:30 PM Mary Carrington, NCI Session 4 POSTER SESSION I TUESDAY 5/20/2014, 8:30 PM # lname Title Talk Length 37 Acosta-Hoyos HIV nucleocapsid protein inhibits ATP-mediated excision by HIV reverse transcriptase 38 Aguiar Reactivation of latent HIV-1 by new semi-synthetic ingenol esters 39 ALI A novel TRIM protein restricts HIV-1 integration by targeting integrase for proteasomal degradation during infection Page 2 of 14 40 ALI Non-canonical HIV-1 Tat secretion through the cellular Na+ K+ ATPase enhances HIV-1 infectivity 41 Anderson Development of droplet digital PCR approaches for detection of HIV with single copy sensitivity 42 Apolonia The hitchhikers’ guide to the viral particle 43 Ariumi Tumor suppressor proteins restricts LINE-1 retrotransposition 44 Arriagada The cytoplasmic dynein complex is important for MLV infection 45 Bacharach MLV infection of mitotic cells—Reduced restriction and microtubule-independent chromosome- targeting 46 Ball Structural and biophysical studies of a second self-associating domain of a Spumavirus Gag 47 Bamunusinghe Most infectious xenotropic and polytropic gammaretroviruses are derived from recombination of two or more endogenous retroviruses 48 Behrens Multiplication of Rev-associated NES domains rescues HIV-1 virion production in murine cells 49 Benichou Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody fragment 50 Bhutoria Molecular modeling of IN-binding domain of INI1 reveals structural similarity to PLAA and residues involved in IN-INI1 interaction 51 Bitzegeio Interferon-induced, envelope dependent restriction of SIVMAC in human lymphocytes 52 Blomberg Classification and characterization of HERVs 53 Blondot Proteomic strategy to highlight how HIV-1 Vpr affects the cellular proteome 54 Bouaziz Structural studies of new bevirimat derivatives with the Gag CA-SP1 junction 55 Browne Interleukin-1 beta promotes retroviral infection and pathogenesis 56 Bruce ZBTB2 regulates HIV-1 transcription 57 Chen The Env protein of SIVsm contributes to the control of BST-2/tetherin 58 Comas-Garcia Single-molecule studies on HIV-1 Gag/RNA interactions 59 Courgnaud Interaction of HIV-2 capsids from primary isolates with cellular factors and disease progression 60 Cyburt Evidence for additional cellular cofactors required for Vpu activity 61 Czubala TGF-β induces a potent post-entry restriction to HIV-1 infection independent of SAMHD1 in immature langerhans cells 62 Daly Effect of non-canonical ribonucleotide incorporation by HIV-1 reverse transcriptase on HIV-1 genomic mutagenesis 63 Datta Associative interactions of the SP1 domain of HIV-1 Gag 64 De Houwer Reduced nuclear import of HIV carrying the transportin-SR2 interaction mutant INR263A/K264A Page 3 of 14 65 De Rijck BET-independent MLV-based vectors integrate efficiently and associate less with proto-oncogene transcription start sites 66 Dharan Efficient HIV-1 uncoating requires microtubules and microtubule associated proteins (MAPs) 67 Diaz The E3 ubiquitin ligase protein Cullin3 regulates HIV-1 transcription in an NF-κB and IRF- dependent manner 68 Diaz-Griffero Contribution of GTPase activity to the ability of MxB to block HIV-1 infection 69 Diaz-Griffero Effects of human SAMHD1 polymorphisms on HIV-1 susceptibility 70 Domaoal Pre-steady state kinetic analysis of HIV-1 reverse transcriptase for non-canonical ribonucleoside triphosphate incorporation and DNA synthesis from mutagenic ribonucleotide-containing DNA template 71 Du Evolutionarily conserved pressure for the existence of multiple distinct substrate recognition domains in HIV-1 Vif 72 Duchon Mechanism of human Lysyl-tRNA synthetase/tRNALys primer recruitment and packaging into HIV-1 73 Dudley To the ER and back again—An unusual trafficking pattern for the Rem protein 74 Durham Distinct functional determinants in the HIV-1 gp41 cytoplasmic tail regulate cell-free versus cell- to-cell infection 75 Ebrahimi Mohammadi Signatures of APOBEC3 on the genome of endogenous and exogenous retroviruses 76 Ebrahimi Mohammadi Source of CpG depletion in HIV 77 Eckwahl Elucidating the retroviral RNA packageome 78 Endsley The intracellular domain of ADAM10 binds HIV-1 integrase to facilitate nuclear trafficking of the pre-integration complex 79 Erikson Mouse Siglec1 enhances the trans-infection of MLV in a sialic acid N-acyl side chain-dependent manner 80 Farley Development of a replication-competent lentivirus (RCL) assay for testing HIV-1-based vectors pseudotyped with a modified alphavirus envelope 81 Fassati Th17 cells master transcription factor RORγ/γt regulates HIV-1 gene expression and integration site selection 82 ferrer Imaging HIV-1 genomic RNA dimers in the cell 83 Finzi Interaction with cellular CD4 exposes HIV-1 envelope epitopes targeted by antibody-dependent cell-mediated cytotoxicity 84 Fricke BI-2 destabilizes HIV-1 cores during infection and prevents binding of CPSF6 to the HIV-1 capsid 85 Fujita SAMHD1-independent functions of HIV-2 Vpx protein 86 Gao HIV-1 hijacks RuvB-like 2 to balance viral protein expression 87 Grewe Substitution of the Rev/RRE system by inclusion of codon-optimized sequences in an HIV-derived lentiviral vector 88 Grznárová Intracellular transport of the MPMV envelope glycoprotein Page 4 of 14 89 Gummuluru GM3 functionalized plasmonic nanoparticles recapitulate CD169-dependent HIV-1 uptake and sequestration within mature
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