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Successful Surgical Repair of Mitral Valve Prolapse Endocarditis: a Case Report and Review of the Current Literature 1 1 2 1 Pavlos N

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Successful Surgical Repair of Mitral Valve Prolapse Endocarditis: a Case Report and Review of the Current Literature 1 1 2 1 Pavlos N Hellenic J Cardiol 2011; 52: 177-181 Case Report Successful Surgical Repair of Mitral Valve Prolapse Endocarditis: A Case Report and Review of the Current Literature 1 1 2 1 PAVLOS N. STOUGIANNOS , DIMITRIOS Z. MYTAS , LAMPRINI K. KOSMA , LOUKAS K. PAPPAS , 1 3 VLASSIOS N. PYRGAKIS , FOTIOS A. MITROPOULOS 1Department of Cardiology, Korinthos General Hospital, Korinthos, 2Radiology Department, A. Fleming General Hospital, 3Athens Medical Centre, Athens, Greece Key words: Mitral We present the case of a 42-year-old man with mitral valve prolapse (MVP) and infective endocarditis. He valve prolapse, was referred to our hospital by his family physician for the evaluation of a cardiac murmur. A detailed medi- endocarditis, surgical repair. cal history revealed that he had been feeling fatigue with occasional episodes of slight fever during the last two months. Echocardiography revealed MVP with a sizeable vegetation and severe mitral insufficiency. Se- rial blood cultures were positive for Streptococcus viridans, highly penicillin susceptible. He was put on ap- propriate antimicrobial therapy, but both the vegetation and the concomitant mitral insufficiency persisted after otherwise successful medical therapy. Thus, the patient underwent surgical vegetectomy with mitral valve repair. He had an uneventful postoperative course and remains free of disease at the 12-month fol- low up. Our case report reinforces the value of early diagnosis in the presence of a high clinical suspicion of MVP endocarditis. An extended clinical workup, including serial detailed echocardiography studies, is man- datory in such a patient. Medical treatment of infective endocarditis in the setting of MVP is often successful. However, cardiac surgical intervention plays an important role in the treatment of intracardiac complications. Mitral valve repair in the context of a healed and stable infective endocarditis is the treatment of choice. Manuscript received: September 12, 2009; Accepted: February 9, 2010. Address: itral valve prolapse (MVP) is man with MVP and infective endocardi- Dimitrios Z. Mytas one of the most prevalent car- tis accompanied by a sizeable vegetation M diac valvular abnormalities, oc- and severe mitral insufficiency, which per- 105 Marathonodromon St. curring in almost 2.4 percent of the popu- sisted after otherwise successful medical 151 25 Marousi, Athens, lation.1 Although the incidence of infec- therapy. The patient underwent surgical Greece e-mail: tive endocarditis in persons with known vegetectomy with mitral valve repair. He [email protected], MVP is quite rare, MVP is the most com- had an uneventful postoperative course [email protected] mon cardiac condition predisposing to in- and remains free of disease at 12-month fective endocarditis.2,3 This is probably follow up. due to the high frequency of this lesion in the general population. Case presentation Medical treatment of infective endo- carditis in the setting of MVP is often suc- A 42-year-old man was referred to our cessful. However, there are cases where outpatient clinic by his family physician surgical intervention is mandatory and, for the evaluation of a cardiac murmur. when feasible, mitral valve repair is pref- On clinical examination, he was afebrile, erable. his blood pressure was 120/80 mmHg and We present the case of a 42-year-old his pulse was 90 beats/min and regular. (Hellenic Journal of Cardiology) HJC • 177 P.N. Stougiannos et al Auscultation revealed a harsh 3/6 holosystolic mur- ably redundant, while a sizeable echogenic mass (10 mur, best heard at the cardiac apex, radiating to the × 11 mm) seemed to be attached to the posterior leaf- sternum. He had no other remarkable physical find- let, prolapsing to the left atrium during systole (Fig- ings except for a noticeable clubbing of his fingers. ure 1). Colour Doppler revealed a large eccentric The patient recalled that from his early adoles- mitral regurgitant jet radiating to the posterior aor- cence a mild cardiac murmur had been diagnosed, tic wall (Figure 2). Quantitative Doppler parameters which was attributed to a mild valvular insufficiency. were consistent with severe mitral regurgitation: vena He had been asymptomatic in his daily life, with ex- contracta 0.84 cm, regurgitant volume 72 ml, regurgi- cellent functional capacity until recently. However, tant fraction 58%, and effective regurgitant orifice ar- during the past two months he had begun to feel con- ea 0.45 cm2. siderable fatigue, with occasional episodes of slight Considering the clinical presentation in associa- fever and sweating, while he noticed a gradual swell- tion with the echocardiographic findings, the diagno- ing of his digits. sis of infective endocarditis superimposed on a redun- The electrocardiogram was unremarkable. Echo- dant proptotic mitral valve seemed very likely. Mul- cardiography showed mild dilatation of the left ven- tiple blood cultures were positive for Streptococcus tricle (end-diastolic diameter 60 mm, end-systolic dia- viridans, highly penicillin susceptible, which made the meter 40 mm) with marginally normal systolic func- diagnosis definite. Regarding the other blood tests, tion (ejection fraction 60%) and an enlarged left atri- there was mild anaemia, increased erythrocyte sedi- um (48 mm). The mitral valve leaflets were remark- mentation rate (90 mm) and C-reactive protein (71 A B Figure 1. Parasternal long axis (A) and four-chamber (B) views depict the thickened and redundant mitral valve leaflets as well as a mass attached to the posterior leaflet, prolapsing to the left atrium during systole. A B Figure 2. Parasternal long-axis (A) and four-chamber (B) views demonstrate the regurgitant jet of severe mitral insufficiency. 178 • HJC (Hellenic Journal of Cardiology) Successful Surgical Repair of MVP Endocarditis mg/dl), normal renal function and mildly impaired inflammation are normal. On echocardiography, left liver biochemistry. The patient was put on appropri- ventricular dimensions are within normal range, the ate anti-microbial treatment with ceftriaxone iv for 4 left atrium is still enlarged but somewhat smaller than weeks. He remained hospitalised for two weeks, while in the baseline study (45 mm). The mitral valve appa- he continued his treatment on an outpatient basis for ratus is well repaired and there are no signs of mitral the remaining time interval. He had an uncomplicat- regurgitation (Figure 3). ed course. However, there was great concern about the fact that the mass attached to the posterior mitral Discussion leaflet (possibly a vegetation), as well as the degree of mitral valve regurgitation, had remained unchanged. MVP is one of the most prevalent cardiac valvular Considering both the size of the vegetation, its hy- abnormalities. Using rigorous echocardiographic cri- permobility and the associated systemic embolic risk, teria, a community-based recent study showed that as well as the significance of the valve insufficiency, MVP syndrome occurs in 2.4 percent of the popula- further surgical intervention was judged mandatory. tion.1 The syndrome is twice as common in women as Preoperative cardiac catheterisation revealed normal in men. However, serious mitral regurgitation occurs coronary arteries and moderate to severe mitral re- more frequently in older men (>50 years) with MVP gurgitation (3-4+/4+) with marginal left ventricular than in young women with this disorder. systolic function. MVP is the most common cause of isolated mi- The operating procedure comprised the trape- tral regurgitation requiring surgical treatment in the zoid resection of the P2 scallop of the posterior mi- United States and the most common cardiac condi- tral valve leaflet with the attached vegetation, sharing tion predisposing patients to infective endocarditis.2 superficial resection of the vegetation from the A2 of Risk factors for infective endocarditis in patients with the anterior leaflet, and mitral annuloplasty with in- MVP include the presence of mitral regurgitation or sertion of a Medtronic C-G No 32 ring. The periop- thickened mitral leaflets. erative and recovery period were uneventful. The pa- The microbiology of infective endocarditis en- tient was discharged on the 7th postoperative day in a grafted on MVP is similar to native valve endocardi- stable, satisfactory clinical condition. The culture of tis that is not associated with drug abuse. Nowadays, the vegetation was negative. Staphylococcus aureus has surpassed viridans group At 12-month follow up the patient remains in streptococci as the leading cause of infective endocar- good clinical condition, afebrile, totally asymptomat- ditis.4 ic, with excellent functional capacity. Moreover, fin- Antimicrobial therapy in endocarditis is guided ger clubbing has been almost entirely resolved. Re- by identification of the causative organism and its sus- petitive blood cultures during this period have been ceptibility to various antimicrobial agents. Prolonged negative, while blood examinations and markers of parenteral administration of a bactericidal antimicro- A B Figure 3. Echo examination at 6-month follow up. Long-axis view (A) reveals a well repaired mitral valve and transmitral flow (B) shows no sign of mitral regurgitation during systole. (Hellenic Journal of Cardiology) HJC • 179 P.N. Stougiannos et al bial agent or combination of agents is currently re- According to recent data, mitral valve repair of- commended. Patients with penicillin-susceptible S. fers excellent early and late results and is the pref- viridans endocarditis
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