Leading Points Concepts in Turbulent Premixed

Total Page:16

File Type:pdf, Size:1020Kb

Leading Points Concepts in Turbulent Premixed LEADING POINTS CONCEPTS IN TURBULENT PREMIXED COMBUSTION MODELING A Dissertation Presented to The Academic Faculty by Alberto Amato In Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy in the School of Mechanical Engineering Georgia Institute of Technology August 2014 Copyright 2014 by Alberto Amato LEADING POINTS CONCEPTS IN TURBULENT PREMIXED COMBUSTION MODELING Approved by: Dr. Tim Lieuwen, Advisor Dr. Yuri Bakhtin School of Aerospace Engineering School of Mathematics Georgia Institute of Technology Georgia Institute of Technology Dr. Jerry Seitzman Dr. P. K. Yeung School of Aerospace Engineering School of Aerospace Engineering Georgia Institute of Technology Georgia Institute of Technology Dr. Caroline Genzale School of Mechanical Engineering Georgia Institute of Technology Date Approved: May 8, 2014 To my parents Carlo and Teresa iii ACKNOWLEDGEMENTS “[The discovery of the Higgs boson] certainly shows to us the value of just imagining… and try to follow the leads that you get from simple ideas… that is worthwhile doing this and see where you come out.” Gerald Guralnik, co-discoverer of the Higgs boson July 4, 2012, www.youtube.com/cerntv This thesis would be incomplete without mentioning several people who assisted, supported and encouraged me during the course of my study. First and foremost, I would like to thank my advisor, Prof. Tim Lieuwen, for his guidance and continuous support during the long and challenging years spent at Georgia Tech. I am neither the first nor I will be the last person to acknowledge Tim’s leadership: he truly has inspired our group to be better thinkers and persons. In a similar vein, I would like to thank Prof. Jerry Seitzman for many insightful comments on my work. His lucid mind and scientific curiosity are infectious and constantly challenge us students to be and do our best. I am also profoundly indebted to Dr. Marcus Day for providing me with many of the data utilized in this thesis and for patiently explaining the many subtleties involved in their analysis. Likewise, I am very appreciative of all the assistance that Prof. Yuri Bakhtin provided to help me understand many mathematical details of this thesis. I would also like to express my gratitude to my committee members, Prof. Caroline Genzale and Prof. P.K. Yeung, for agreeing to serve on my committee in spite of their extremely busy schedules, and for offering constructive and valuable critiques regarding my research work. The Ben T. Zinn Combustion Laboratory provided me with the perferct home during all the years of my doctorate. Andrew Marshall and Prabhakar Venkateswaran, with the late iv addition of Julia Lundrigan, were my companions in this research project. I shared with them many highs and lows, so frequent in turbulent combustion research, and this work would not have been possible without their help. I am very grateful to Vishal Acharya, Dong-Hyuk Shin, Shreekrishna and Jack Crawford for helping me understand many aspects of combustion theory and numerical computations. I will always cherish the memory of the time spend shoulder to shoulder in our office with also Jordan Blimbaum. Our “legacy” is in good hands with Nick Magina and Luke Humprey. The “experimentalists” (in no particular order) Jacqueline O’Connor (“Lab-mom”), Chris Foley, Ben Emerson, Ben Wilde, Bobby Noble, Brandon Sforzo, Ianko Chterev, Mike Aguilar, Michael Malanoski, Ryan Sullivan, Sai Kumar, Yash Kochar, Benjamin Knox and Gina Magnotti, were always kind to me and a true source of inspiration. Here I would also like to acknowledge the many “slivers” of Italy that I befriended in Atlanta and helped me miss less my home. In August 2008 I arrived in the United States with Daniele Bertolotti and Paolo Manenti; for the first few months, before they moved back to Italy, they were my roomates and travelmates, without them I would have not enjoyed as much this experience. Matteo Senesi and Luca Airoldi shared with me the choice of staying longer in the US to pursue a PhD. Our summer trip to Savannah with Alice Sacchetti and Andrea Trimarco will always remain one of my funniest memories. Martina Baroncelli shared with me one year of life at the Combustion Lab. When she arrived at the lab from Florence, I immediately started to appreciate the pleasure of hearing a familiar “buongiorno” in a Tuscan accent first thing in the morning. Finally, I would like to thank my family for its unfailing support during these years. To my parents Carlo and Teresa goes all my affection. My uncle Roberto with his wife Sara v and their children Antonio and Elisagiulia never failed to cheer me up with their Skype phonecall. My cousins Pierluigi and Silvia with my grandmother Elisabetta, my uncle Guido and aunts Manuela and Giovanna were always the first people that I wanted to see when traveling home for Christmas and have been always a source of strength for me. Unfortunately, my uncle Davide passed away at a very young age while I was in the middle of my graduate studies. He had been enthusiastic and encouraging about my studies since day one. To him goes my deepest graditude. vi TABLE OF CONTENTS Acknowledgements .......................................................................................................... iii List of Tables .....................................................................................................................ix List of Figures ..................................................................................................................... x Symbols and Abbreviations ......................................................................................... xxii Summary ......................................................................................................................... xxv CHAPTER 1: Introduction ............................................................................................... 1 1.1 Motivation ............................................................................................................... 1 1.2 Molecular transport effects on turbulent premixed flame propagation and structure: experimental evidence ........................................................................... 4 1.3 Scope and organization of the thesis....................................................................... 9 CHAPTER 2: Background.............................................................................................. 11 2.1 Preferential diffusion and Lewis number effects .................................................. 11 2.1.1 Flame speed definitions ............................................................................... 19 2.1.2 Nonlinear and unsteady effects .................................................................... 27 2.2 Turbulent premixed combustion modeling ........................................................... 35 2.3 Lewis number and preferential diffusion effects: direct numerical simulations of turbulent premixed flames ................................................................................... 41 2.4 Leading points concept ......................................................................................... 54 2.4.1 Leading points burning rates ........................................................................ 55 2.4.2 Dynamical significance of leading points .................................................... 57 CHAPTER 3: Leading IPoints IBurning IRates.............................................................. 63 3.1 Numerical procedures ........................................................................................... 65 3.2 Definitions ............................................................................................................ 69 3.3 One dimensional numerical simulations ............................................................... 73 3.4 Turbulent flame front structure ............................................................................. 77 3.4.1 Local flame front curvatures, shapes and strain rates .................................. 77 3.4.2 Case A31 ...................................................................................................... 82 vii 3.4.3 Case B31, C31 and D31 ............................................................................... 84 3.4.3.1 Cylindrical and spherical flamelets ...................................................... 89 3.4.3.2 Flamelets with low curvature ............................................................... 93 3.5 Flame front structure at the leading edge.............................................................. 96 3.6 Conclusions ......................................................................................................... 102 CHAPTER 4: Leading IPoints IDynamics .................................................................... 105 4.1 G-equation .......................................................................................................... 107 4.2 Problem formulation and mathematical background .......................................... 109 4.2.1 One dimensional problem formulation ...................................................... 109 4.2.2 Hopf-Lax formula and Huygens propagation ............................................ 113 4.2.3 Aubry-Mather theory ................................................................................. 114 4.2.4 Definition of Aubry-Mather Leading Points .............................................. 120 4.3 Example problem ...............................................................................................
Recommended publications
  • A PARTNER for CHANGE the Asia Foundation in Korea 1954-2017 a PARTNER Characterizing 60 Years of Continuous Operations of Any Organization Is an Ambitious Task
    SIX DECADES OF THE ASIA FOUNDATION IN KOREA SIX DECADES OF THE ASIA FOUNDATION A PARTNER FOR CHANGE A PARTNER The AsiA Foundation in Korea 1954-2017 A PARTNER Characterizing 60 years of continuous operations of any organization is an ambitious task. Attempting to do so in a nation that has witnessed fundamental and dynamic change is even more challenging. The Asia Foundation is unique among FOR foreign private organizations in Korea in that it has maintained a presence here for more than 60 years, and, throughout, has responded to the tumultuous and vibrant times by adapting to Korea’s own transformation. The achievement of this balance, CHANGE adapting to changing needs and assisting in the preservation of Korean identity while simultaneously responding to regional and global trends, has made The Asia Foundation’s work in SIX DECADES of Korea singular. The AsiA Foundation David Steinberg, Korea Representative 1963-68, 1994-98 in Korea www.asiafoundation.org 서적-표지.indd 1 17. 6. 8. 오전 10:42 서적152X225-2.indd 4 17. 6. 8. 오전 10:37 서적152X225-2.indd 1 17. 6. 8. 오전 10:37 서적152X225-2.indd 2 17. 6. 8. 오전 10:37 A PARTNER FOR CHANGE Six Decades of The Asia Foundation in Korea 1954–2017 Written by Cho Tong-jae Park Tae-jin Edward Reed Edited by Meredith Sumpter John Rieger © 2017 by The Asia Foundation All rights reserved. No part of this book may be reproduced without written permission by The Asia Foundation. 서적152X225-2.indd 1 17. 6. 8. 오전 10:37 서적152X225-2.indd 2 17.
    [Show full text]
  • Feasibility Study on Approaches to Aggregate OTC Derivatives Data
    Feasibility study on approaches to aggregate OTC derivatives data 19 September 2014 Contents Page Executive Summary ................................................................................................................... 1 Introduction ................................................................................................................................ 3 1. Objectives, Scope and Approach ....................................................................................... 5 1.1 Objectives and Scope of the Study ............................................................................. 5 1.2 Aggregation Models Analysed ................................................................................... 5 1.3 Preparation of the Study ............................................................................................. 8 1.4 Definition of Data Aggregation .................................................................................. 8 1.5 Assumptions ............................................................................................................... 9 2. Stocktake of Existing Trade Reporting ............................................................................ 10 2.1 TR reporting implementation and current use of data .............................................. 10 2.2 Available data fields and data gaps .......................................................................... 11 2.3 Data standards and format .......................................................................................
    [Show full text]
  • CURRICULUM VITAE Dong Hyuk Shin
    1 CURRICULUM VITAE Dong Hyuk Shin Clinical Assistant Professor of Sport Management Room 266, Cleveland Hall, PO Box 642136 Department of Educational Leadership, Sport Studies, and Educational/Counseling Psychology College of Education, Washington State University Pullman, WA 99164-2136 Tel: 509-335-3069 Cell: 850-980-1294 Fax: 509-335-6961 [email protected] EDUCATION Ph.D. University of Iowa, Dec 2015 College of Education (Iowa City, Iowa) Department of Educational Policy and Leadership Studies Higher Education and Student Affairs program Areas of Concentration: Higher Education Organization and Administration Dissertation: Okay, Seminoles, take over from here: Native American mascot and nickname as organization builders at Florida State University (Advisor: Dr. Christopher Morphew) M.A. University of Iowa, Dec 2010 College of Liberal Arts and Sciences (Iowa City, Iowa) Department of Health and Sport Studies Areas of Concentration: Sport Studies (History and Sociology of Sport) M.S. Florida State University, Dec 2006 College of Education (Tallahassee, Florida) Department of Sport Management, Recreation Management and Physical Education Areas of Concentration: Sport Management and Athletic Administration B.A. Hankook University of Foreign Studies, Feb 1997 College of Occidental Studies (South Korea) Major: Hungarian Studies Minor: Political Science Kossuth Lajos Tudományegyetem (University of Debrecen), Jul-Aug 1995 Completed Intensive Hungarian Language and Culture Course (Debrecen, Hungary) 2 TEACHING AND PROFESSIONAL EXPERIENCE
    [Show full text]
  • FALL 2019 Lubbock, Texas December 13-14
    Commencement FALL 2019 Lubbock, Texas December 13-14 FALL 2019 Commencement Friday, December 13, 2019 2:30 p.m. and 7:30 p.m. Saturday, December 14, 2019 9:00 a.m. and 1:30 p.m. UNITED SUPERMARKETS ARENA LUBBOCK, TEXAS TABLE OF CONTENTS Administration | 3 About Texas Tech University | 4 Undergraduate and Graduate Commencement Ceremonies | 8 Commencement Speakers | 12 Acknowledgements | 13 Convocations Committee Music Ensemble College Readers Administrative Representatives Program Production Student Banner Bearers for Ceremonies Faculty Banner Bearers for Ceremonies Library Banner Bearers for Ceremonies Presidential Mace | 14 Graduation Honors | 14 List of Graduate Degree Candidates | 15 List of Undergraduate Degree Candidates | 23 Receptions | 35 College Banners | 36 Academic Dress and Procession | 38 Seating Charts | 40 MISSION As a public research university, Texas Tech advances knowledge through innovative and creative teaching, research, and scholarship. The university is dedicated to student success by preparing learners to be ethical leaders for a diverse and globally competitive workforce. The university is committed to enhancing the cultural and economic development of the state, nation, and world. 2 TEXAS TECH UNIVERSITY TEXAS TECH UNIVERSITY ADMINISTRATION LAWRENCE E. SCHOVANEC, Ph.D. President; Professor of Mathematics and Statistics MICHAEL L. GALYEAN, Ph.D. JOSEPH HEPPERT, Ph.D. Provost and Senior Vice President; Vice President for Research; Horn Professor of Animal and Food Sciences Professor of Chemistry NOEL SLOAN, J.D., CPA CAROL SUMNER, Ed.D. Vice President for Administration & Finance, Chief Diversity Officer and Vice President of Chief Financial Officer the Division of Diversity, Equity & Inclusion TEXAS TECH UNIVERSITY SYSTEM CHANCELLOR / BOARD OF REGENTS TEDD L.
    [Show full text]
  • Information Display January 2008
    ELECTRONIC-PAPER ISSUE January 2008 Vol. 24, No. 1 SID Official Monthly Publication of the Society for Information Display • www.informationdisplay.org Has E-Paper Finally Arrived? G Electrochromics: Unlocking Color in E-Paper G E-Paper Manufacturing G Electronic Paper: Past, Present, and Future G Early Days of LCD Research and Development G Journal of the SID January Preview MicroTouch is Going Mobile Expanding thePossibilities 3M Touch Systems MicroTouchTM Flex Capacitive Touch Sensors for Mobile Applications • Nearly Invisible ITO Proprietary index matching technology to minimize ITO visibility • Ultrathin Substrate 0.05 mm PET substrate enables compact design • Creative Form Factors Allows designers the freedom to explore a myriad of shapes • High Volume Production Roll process is capable of producing millions of units per month Learn more about MicroTouch Going Mobile by calling 888-659-1080 or visit www.FlexCapTouch.com for details. 3M ©3M 2007 © 2007 MicroTouch MicroTouch is a trademarks is a trademarks of the of the3M Company.3M Company. Cover: On November 19, 2007, Amazon, the JANUARY 2008 world’s largest on-line retailer, announced with Information VOL. 24, NO. 1 great fanfare the launch of the Kindle, a portable reader that wirelessly downloads books, blogs, magazines, and newspapers to a high-resolution electronic-paper display. While this certainly is far from the first e-reader that utilizes electronic-paper DISPLAY technology to create a paper-like display, the Kindle introduction sparked hopes that it could 2 Editorial serve as the “killer application” that truly launches Notes from the Front Line of Backlights e-paper products into the consumer mainstream.
    [Show full text]
  • 한국생물공학회 창립 30주년 기념 학술발표대회 및 국제심포지엄 30Th Anniversary Meeting and International Symposium of KSBB
    한국생물공학회 창립 30주년 기념 학술발표대회 및 국제심포지엄 30th Anniversary Meeting and International Symposium of KSBB 2015.10. 11(일) ~ 14(수) 송도컨벤시아, 인천 October 11(Sun) ~ 14(Wed), 2015 Songdo Convensia, Incheon, Korea 위원장 : 홍억기 교수 (강원대학교) 위 원 : 권순조 교수 (인하대학교), 김현철 교수 (서강대학교) 김중배 교수 (고려대학교), 김준형 교수 (동아대학교) 박현규 교수 (KAIST), 서정현 교수 (영남대학교) 오민규 교수 (고려대학교), 윤현식 교수 (인하대학교) 이원종 교수 (인천대학교), 이철균 교수 (인하대학교) 전태준 교수 (인하대학교), 정기준 교수 (KAIST) 차형준 교수 (POSTECH), 최신식 교수 (명지대학교) 최유성 교수 (충남대학교), 최윤이 교수 (고려대학교) 최종훈 교수 (한양대학교), 홍종욱 교수 (한양대학교) • 장소 및 일정 ◦ 일 시 : 2015년 10월 11일(일) ~ 14일(수) ◦ 장 소 : 송도컨벤시아 ◦ 주 최 : 한국생물공학회 • 프로그램 PlenaryLecture ◦ 일시: 2015년 10월12일(월)-14일(수) ◦ 장소: 송도컨벤시아 프리미어볼룸 ◦ 연사: Prof. James Swartz (Stanford University, Stanford, USA) Senior Vice President Do Young Seung (GS-Caltex R&D Center, Korea) Prof. John A. Rogers (University of Illinois at Urbana Champaign, USA) Prof. Peixuan Guo (University of Kentucky, Lexington, USA) Symposium ◦ 일시: 2015년 10월12일(월)-14일(수) ◦ 장소: 송도컨벤시아 세미나장 ◦ 프로그램: 9 International Symposia, 16 Special Symposia, 2 수상특강, 부문위원회발표, 학생구두발표, 대중강연, 장비워크샵, 4 Luncheon Seminars, 포스터발표 등 Exhibition ◦ 일시: 2015년 10월12일(월)-13일(화) ◦ 장소: 송도컨벤시아 제 1전시장 ◦ 출품품목: 바이오/의료 (바이오제품, 실험장비, 실험기자재 및 소모품 등), 서비스 (분석, 평가) 연구사업기관 등 ◦ 참여부스: 총 50기관, 80부스 Special Events ◦ 한국생물공학회 역사물 전시 ◦ 일시: 2015년 10월12일(월)-13일(화) ◦ 장소: 송도컨벤시아 제 1전시장 한국생물공학회 창립 30주년 기념식 및 30년사 발간기념 행사 ◦ 일시: 2015년 10월12일(월) 16:45~18:30 ◦ 장소: 송도컨벤시아 프리미어볼룸 Welcoming Reception ◦ 일시: 2015년 10월12일(월) 18:30~20:00 ◦ 장소: 송도컨벤시아 프리미어볼룸 *학생회원 제외 바이오는 우리손으로!!! (학생파티) ◦ 일시: 2015년 10월12일(월) 18:30~20:00 ◦ 장소: 송도컨벤시아 제 1전시장 - 퍼즐진행, 기념품 증정 • 논문발표 1.
    [Show full text]
  • The 19Th Annual KOTESOL International Conference Seoul, Korea, October 15-16, 2011
    KOTESOL Proceedings 2011 Pushing our Paradigms; Connecting with Culture Proceedings of the 19th Annual KOTESOL International Conference Seoul, Korea, October 15-16, 2011 Korea Teachers of English to Speakers of Other Languages (Korea TESOL / KOTESOL) KOTESOL Proceedings 2011 Pushing our Paradigms; Connecting with Culture Proceedings of the 19th Annual KOTESOL International Conference Seoul, Korea October 15-16, 2011 Edited by Korea TESOL Proceedings Editors-in-Chief Dr. David Shaffer Chosun University, Gwangju, Korea Maria Pinto Universidad Tecnologica de la Mixteca, Huajuapan de Leon, Mexico Publications Committee Chair Dr. Jong-hee Lee Layout/Design: Mijung Lee, Media Station Printing: Myeongjinsa For information on this or other Korea TESOL publications, as well as inquiries on membership and advertising, contact us at: www.koreatesol.org or [email protected] © 2012 Korea Teachers of English to Speakers of Other Languages (Korea TESOL / KOTESOL) ISSN: 1598-0472 Price: 10,000 KRW / 10 USD. Free to Members 4 Conference Committee of the 19th Annual Korea TESOL International Conference Julien McNulty Conference Committee Chair Stafford Lumsden David E. Shaffer Stephen-Peter Jinks Conference Co-Chair Financial Affairs Director Conference Advisor Philip Owen Kyungsook Yeum Sean O’Connor Program Director Venue Director Technical Director Vivien Slezak Curtis Desjardins Louisa Kim Guest Services Director Support Services Director Registration Director Robert Dickey Grace Wang Gina Yoo Webmaster Financial Affairs Asst. Director Registration
    [Show full text]
  • 2013-2014 Annual Report
    School of Dentistry Table of CONTENTS An Education Groundbreaking of Exceptional Research to Conquer 3 5 Value 15 Diseases Celebrating • Class of 2014 Graduates • Grants by Funding Sources Fifty Years: • Scholarships/Fellowships/Grants • NIH Grants by Institute • Postgraduate Training Certificates • Research Highlights 1964-2014 • Oral Biology Degrees • Awarded Contracts & Grants • International Training Programs • New Contracts & Grants • Continuing Dental Education • Research Publications Members from the Class of 2017 at the annual White Coat Ceremony, a tradition that helps introduce incoming DDS students to UCLA. i UCLA School of Dentistry Commitment to Dedicated A Foundation Patient Care & Faculty & Staff for the Future 29 Public Service 39 49 • Patient Visits • New Faculty • Revenue by Source • Community Partnerships • Academic Personnel Actions • Development by the Numbers • Clinical Care Sites & Health Fairs • Faculty Honors/Retirements • Development Highlights/ • Care Harbor • Staff Personnel Actions/ Board of Counselors • Give Kids A Smile Years of Service • Alumni Affairs/Achievements • Outreach & Diversity • Staff Honors Page 57 - Recognition • Academic Personnel • Group Practice Directors/Dental Hygiene Faculty/Clinic Volunteers • In Memoriam • Honor Roll of Donors • Apollonian Society Donors 2013-2014 Annual Report ii Fifty years ago, in 1964, the UCLA School of Dentistry opened its doors to the first DDS class, marking the MESSAGE beginning of our legacy of excellence. I am astounded by the progress we have made over the decades, and I am Dean’s confident that we have accomplished the vision that the University of California had when they set out to build a world-class dental school on the UCLA campus. During the 2014-2015 fiscal year, a series of events and symposiums will be held to commemorate our 50th Anniversary.
    [Show full text]
  • Green Mountain Book Award Handbook 2014-2015
    Green Mountain Book Award Handbook 2014-2015 Compiled by the Green Mountain Book Award Committee State of Vermont Department of Libraries 109 State Street Montpelier, VT 05609-0601 http://libraries.vermont.gov/libraries/gmba This publication is supported by the Institute of Museum and Library Services, a federal agency, through the Library Services and Technology Act. TABLE OF CONTENTS Page Introduction 1 Winners of the Green Mountain Book Award 3 GMBA Masterlist 4 How to Apply for the Committee 7 Book Suggestion Form 8 Black: The Coldest Girl in Coldtown 9 Cline: Ready Player One 12 Cronn-Mills: Beautiful Music for Ugly Children 14 Harden: Escape from Camp 14 16 Kraus: Rotters 18 LaFevers: Grave Mercy 20 Levithan: Every Day 23 Martinez: Emperor Mollusk versus The Sinister Brain 27 McNeil: Ten 30 Mignola: Joe Golem and the Drowning City 32 Padian: Out of Nowhere 34 Rowell: Eleanor & Park 36 Salerni: The Caged Graves 38 Wynne-Jones: Blink and Caution 40 Yancey: The 5th Wave 43 Student GMBA Checklist 45 INTRODUCTION The Green Mountain Book Award is the student-selected award for Vermonters in grades 9-12. In 2005 it joined the other two Vermont child-selected book awards, the Red Clover Award, a picture book award for children in Kindergarten-grade 4, and the Dorothy Canfield Fisher Award, a book award for students in grades 4-8. Mission statement The goal of the award is to select a list of books of good literary quality that: • Engages high school students. • Represents a variety of genres, formats and viewpoints. • May include books written both for young people and adults.
    [Show full text]
  • UNIVERSITY of CALIFORNIA Los Angeles Yes Associated Protein
    "#$%&'($)*!+,!-./$,+'#$.! /01!.234541! ! ! ! ! *41!.11067894:!;<09472!;58=1!82!&11429785!'054!72!9>4!?4@450AB429!82:!;<03<411702! 0C!D48:!82:!#46E!(FG8B0G1!-455!-8<6720B8! ! ! ! ! .!:7114<989702!1GHB7994:!72!A8<9785!18971C869702!0C!9>4! !<4FG7<4B4291!C0<!9>4!:43<44!?0690<!0C!;>75010A>=!! 72!+<85!I70503=! ! H=! ?8@7:!D!I84! ! ! JKLM! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! © Copyright by David H Bae 2014! ! ABSTRACT OF THE DISSERTATION Yes Associated Protein Plays an Essential Role in the Development and Progression of Head and Neck Squamous Cell Carcinoma By David H Bae Doctor of Philosophy in Oral Biology University of California, Los Angeles, 2014 Professor Cun-Yu Wang, Chair The intricate anatomy of the primary tumor, the occurrence of late-stage diagnosis, combined with the aggressive nature of head and neck squamous cell carcinoma (HNSCC) has made this disease difficult to treat. The global rate of HNSCC continues to rise, accounting up to 25% of all new cancer cases. But despite advances in treatment, the five year survival rate has remained stagnant for decades. Therefore a clearer understanding of the formation and progression of HNSCC is essential to the development of better therapeutic approaches to prevent and treat HNSCC patients. Recent studies have identified yes associated protein (YAP) ii as a potential target. YAP is a highly conserved transcriptional coactivator and has been found amplified as well as its expression upregulated and active in HNSCCs. In this study we hypothesize that YAP plays a key role in the development and progression of HNSCC. Our results show that activated YAP can transform and induce epithelial to mesenchymal transition (EMT) of our immortalized but nontransformed oral keratinocyte cell line OKF6 as seen by its ability to increase proliferation, saturation density, invasion, and induce anchorage independent growth.
    [Show full text]
  • KOTESOL Proceedings 2010 Advancing ELT in the Global Context
    KOTESOL Proceedings 2010 Advancing ELT in the Global Context Proceedings of PAC 2010 The Pan-Asia Conference The 18th Annual KOTESOL International Conference Seoul, Korea; October 16-17, 2010 Korea Teachers of English to Speakers of Other Languages (Korea TESOL / KOTESOL) KOTESOL Proceedings 2010 Advancing ELT in the Global Context Proceedings of PAC 2010 The Pan-Asia Conference The 18th Annual KOTESOL International Conference October 16-17, 2010; Seoul, Korea Edited & Published by Korea TESOL Proceedings Editors-in-Chief Maria Pinto Dr. David Shaffer Dongguk University, Gyeongju Chosun University, Gwangju KOTESOL Publications Committee Chair Dr. Mee-Wha Baek, Ajou University Proceedings Editorial Staff Sarah Emory Elliott Walters Southwest University of Southwest University of Science and Technology Science and Technology Sichuan, China Sichuan, China Sharon de Hinojosa References Editor Sungkyunkwan University Dr. David Shaffer Suwon Campus Chosun University Layout/Design: Mijung Lee, Media Station Printing: Myeongjinsa For information on this or other Korea TESOL publications, as well as inquiries on membership and advertising, contact us at: www.koreatesol.org or [email protected] © 2011 Korea Teachers of English to Speakers of Other Languages (Korea TESOL / KOTESOL) ISSN: 1598-0472 Price: 10,000 KRW / 10 USD. Free to Members 4 Conference Committee of PAC 2010 - The Pan-Asia Conference The 18th Annual Korea TESOL International Conference Dr. Kyungsook Yeum Stephen-Peter Jinks PAC 2010 Conference Chair Conference Committee Chair Julien McNulty Philip Owen Dr. David Shaffer Conference Co-Chair Program Chair Conference Advisor Louisa Lau-Kim Vivien Slezak Stafford Lumsden Registration Chair Guest Services Chair Support Services Chair Sean O’Connor Dr.
    [Show full text]
  • Commencement
    Commencement December 2015 Iowa City, Iowa Cover Design: The cover design represents the gold and topaz medallion worn by The University of Iowa president at formal academic ceremonies on campus. The medallion was designed and made by Karen Cantine as part of the work for her M.A. conferred August 4, 1965. 2 The University of Iowa Commencement Ceremonies Friday, December 18, 2015 Graduate College Carver-Hawkeye Arena 7:00 p.m. Saturday December 19, 2015 Liberal Arts and Sciences, Business, Medicine, and University College Carver-Hawkeye Arena 9:00 a.m. Nursing Iowa Memorial Union 10:00 a.m. Engineering Macbride Hall Auditorium 12:00 p.m. 3 4 Table of Contents University Leaders ............................................................................................................................................................... 7 Graduate College Ceremony - Order of Events, Friday, December 18, 2015 ............................................................ 8 Undergraduate Ceremony - Order of Events, Saturday, December 19, 2015 .......................................................... 10 Candidates for Degrees, December 18, 2015 ................................................................................................................. 13 Official List of Degrees Conferred, August 7, 2015 ..................................................................................................... 35 Honorary Degrees Awarded by the University of Iowa ............................................................................................
    [Show full text]