MEDIA KIT 2O2O prix galien usa New YORK CITY, OctOber 29, 2020 innovation to improve the human condition

Mission PRe-eveNT & ON-sITe ResOuRCes fOR JOuRNalIsTs the Prix Galien Award recognizes outstanding achievements Galien Foundation events are conducted fully on the record, and in improving the global human condition through the development of innovative drugs and other treatments. we welcome and invite members of the media to participate as Sue Desmond-Hellmann, engaged stakeholders via on-site discussion, as well as via social the Prix Galien was created in 1970 in honor of Galien, Ethiopia Clinic site visit media, and to report on proceedings and outcomes. the father of medical science and modern pharmacology. th Worldwide the Prix Galien is regarded as the equivalent of 2020 : Prix Galien’s 50 Anniversary We certainly appreciate coverage of our events, but our priority Our diverse geographic reach is evident with the International the Nobel Prize in biopharmaceutical research. Prix Galien Awards, which launched in 1990, and is conducted is to help journalists explore and examine today’s key issues Africa Now! Senegal, Africa Selected As Permanent Host every two years to highlight the "best of the best" in research that and connect with the people and diverse organizations we bring for the International Prix Galien Awards ceremony and brings dividends to patients across geographies with differing together that make the world a healthier place. The Prix Galien is more than an award: it is a movement with a Launch of the Prix Galien Africa. mandate to foster, recognize and reward excellence in scientific health needs. This desire to make biopharmaceutical and med To help facilitate your engagement with our speakers and innovation to improve the state of human health. Building on an The Prix Galien Golden Jubilee : 2020 is a landmark year tech innovation a global endeavor, bringing progress to patients in all corners of the world, will now be a key priority for the Prix stakeholders, we are delighted to work with you in the lead-up unrivaled network of top biomedical scientists including Nobel celebrating 50 years of progress in recognizing excellence in Galien community going forward. to our 2020 Forum and Ceremony on: Laureates in medicine, the Prix Galien manages an independent, biopharmaceutical and med tech innovations to improve the cross-functional and geographically diverse program of human condition. Under the sponsorship of the government of Senegal and the • Arranging interviews with key speakers and stakeholders events and sponsorships to brand “the best of the best” in new As a special feature our 50th Golden Jubilee year will honor WHO Regional Office for Africa, the Prix Galien Africa is our medicines and diagnostics. first truly region-wide initiative. It stands as a living tribute to • Reserving private spaces for on-site interviews the “global best of the very best” in: A- Pharmaceutical; Our scope is global, and our commitment to progress in medicine B- Biotechnology; C- Orphan and Rare diseases; D- ; the vision of Foundation co-founder, 1986 Nobel peace laureate • Sharing our latest programs and speaker lists is both measurable and concrete. Our members express this and E- Medical technology products. Eligibility will be drawn Elie Wiesel, who believed in medical innovation not only as an through the establishment of productive relationships to build from the 250 products awarded the Prix Galien by our 14 industrial policy asset but as a source of social progress, where • Providing hi-resolutions imagery (including photos lasting bridges between the commercial research enterprise member-country chapters since 1970, developed by more than private enterprise and public engagement combine to deliver a of people, spaces, logos, etc.) and local communities engaged in public policy, science, finance, 80 innovative companies, most of whom continue to bring new greater public good – health equity and access for all. academic research and the media. therapies for today’s patients with unmet medical needs. We invite all communities with a commitment In addition to recognizing advances in promising therapies, the The Galien Forum and Prix Galien USA Ceremony will take place to the conduct and promotion of life sciences fOR mORe INfORmaTION aNd RegIsTeR Prix Galien’s annual Roy Vagelos Pro Bono Humanum Award on October 29 in New York City at the Alexandria Center for Life innovation to contribute to this important work. fOR a PRess Pass Please CONTaCT: for humanitarian achievements (www.galienfoundation.org/ Science and Museum of Natural History, respectively. During the index.php/2017/01/31/probono) brings a unique focus to the Ceremony, we will also announce the short list for the “Awards intersection between science, business and politics. The outcome of the Jubilee” – which will be selected by all past and present FINN PArtNerS we seek is guided by the synthesis principle that underpins the Committee members across the globe. Holmes Report & PR News / Midsize Agency of the Year cOnTEnT conduct of science itself: successful innovation where financing, The Golden Jubilee awards will be announced on December 11, cONtAct: physical assets, knowledge and skills are combined from many 2020 in Dakar in the presence of the President of the Senegalese • Kara Bradley, Account Supervisor sources to move new ideas quickly “from the bench to the Republic, H.E. Macky Sall, alongside many African heads of state PRIx GALIEN USA FOUNDING COMMITTEE ...... 4 bedside,” on behalf of patients everywhere. T: +1 646 213 7243 - [email protected] and ministers of health and/or environment, the WHO Director- 2020 AWARDS COMMITTEE ...... 5 General as wel,l as hundreds of scientists and industry and innovation • Merissa Muller, Account Supervisor A truly global program present leaders. GALIEN FORUM ...... 6 T: +1 617 778 6633 - [email protected] Overview & Background in 15 countries* The best locale to pursue our mission is the African continent, “They participated in the Forum” whose young population is destined to double to 2.5 billion people Our program includes a review of contributions from a new HeLPFuL LINkS : www.galienfoundation.org by 2050. According to the World Economic Forum, early-stage TESTIMONIALS FROM AROUND THE GLOBE ...... 8 generation of innovators representing diverse sectors in health. entrepreneurial activity is nearly 15% higher in Africa than the • Prix Galien USA Our mission is to advance cross-cultural contacts and harmonize HALL OF FAME global average – yet while the continent is today home to 11% regulation, internal business processes, new information HISTORY OF THE PRIZE AND MEDAL...... 10 • Forum (latest programs, participants, registration of the world’s population, it accounts for a mere 1% of total technologies and public-private partnerships to remove barriers and reports) health spending and carries a crippling 25% of the global disease PRIx GALIEN USA ...... 11 to the commercialization of good medicines and expand across to burden. Taken together, these statistics reveal the progress • Pro Bono Humanum Award these benefits to all who need them. THE ROY VAGELOS PRO BONO HUMANUM AWARD...... 12 inherent in what in a few years will be the world’s youngest and • Med StartUp Award potentially most productive population, but whose prospects WHO WAS GALEN ...... 13 • Prix Galien Around the Globe depend on more investment in health care as the key driver of PRIx GALIEN MEDSTART UP ...... 14 • Prix Galien Hall of Fame development. PRIx GALIEN USA WINNERS ...... 15 Summary of past 50 years of Prix Galien awards * Africa, Belgium, Canada, China, France, Germany, Greece, Italy, Netherlands, Poland, Russia, Spain, Switzerland, United Kingdom and the United States. “ Thanks to their gifts to society and their determination to alleviate and cure its woes, the scientists deserve to be ranked among prix galien usa the true friends of the human race.” prix galien usa Susan DESMOND-HELLMANN, MD, MPh Elie WiESEL in Memoriam Committee Chair cOMMITTEE Honorary Founding President cOMMITTEE Former Chief Executive Officer The Galien Foundation Bill & Melinda Gates Foundation 2OO7-2O1 1 Peace Nobel Laureate 2O2O Boston University

Michael S. BROWN, MD Barry S. COLLER, MD Walter GiLBERT, PhD Joseph GOLDSTEiN, MD Richard AXEL, MD Linda B. BUCK, PhD Susannah FOX Laurie GLiMCHER, MD Joseph GOLDSTEiN, MD Nobel Laureate Vice President for Nobel Laureate Nobel Laureate Nobel Laureate Nobel Laureate Former Chief President and CEO Nobel Laureate Professor of Molecular Medical Affairs Professor Emeritus Professor of Molecular Co-director Fred Hutchinson Cancer Technology Officer Dana Farber Cancer Professor of Molecular Genetics and Internal and Physician-in-Chief, Genetics and Internal The Kavli Institute for Research Center member, U.S. Department of Health Institute; Genetics and Internal Medicine Medicine Brain Science. Columbia and Professor of Physiology and Human Services Professor of Medicine Medicine UT Southwestern UT, Southwestern University Medical Center and Biophysics Harvard Medical School UT, Southwestern Medical Medical Center at Dallas Medical Center at Dallas University of Washington Center at Dallas

Paul GREENGARD, PhD Eric R. KANDEL, MD Joshua LEDERBERG, Richard A. LERNER, MD Mary-Claire KiNG, PhD Robert S. LANGER, ScD Cato T. LAURENCiN, Steven LESTER, MD Paul A. MARKS, MD Nobel Laureate Nobel Laureate MD, PhD Professor of American Cancer Society David H. Koch Institute MD, PhD Chief Medical Officer Laboratory Head Professor of Molecular Professor of physiology Nobel Laureate Immunochemistry, Chair Professor of Genome Professor University Professor Mayo Clinic-ASU of Cell Biology and Cellular Neuroscience and Cellular Biophysics Professor Emeritus, in Chemistry Sciences and Medical Massachusetts Institute University of Connecticut MedTech Accelerator Memorial Sloan Kettering Rockefeller University Laboratory of Molecular Scripps Research Institute Genetics of Techonology Cancer Center Genetics and Informatics, University of Washington Rockefeller University

Paul A. MARKS, MD Bengt SAMUELSSON, Jan T. ViLCEK, MD Gerald WEiSSMANN, MD Michael ROSENBLATT, Bengt SAMUELSSON, Marc TESSiER-LAViGNE, P. Roy VAGELOS, MD Tachi YAMADA, MD Laboratory Head of Cell Biology MD, PhD Professor of Microbiology Professor of Rheumatology MD MD, PhD PhD Prix Galien USA Venture Partner Memorial Sloan Kettering Nobel Laureate New York University School and Director of Chief Medical Officer Nobel Laureate President Committee Chairman Frazier Healthcare Cancer Center Professor of Medicine Biotechnology Study Center Flagship Pioneering Professor Stanford University 2012-2017 Partners Karolinska Institutet; New York University School Karolinska Institutet; Retired Chairman and CEO Former President of Medicine Former President Merck & Co., Inc.; Karolinska Institutet; Karolinska Institutet; Chairman of the Board Former Chairman Former Chairman Regeneron Nobel Foundation Nobel Foundation Pharmaceuticals, Inc. 4 5 Among THE PREVIoUS Galien FoRUM Galien FoRUM OCTObeR 29, 2O2O - 7:3O am aleXaNdRIa CeNTeR fOR lIfe sCIeNCe sPeaKeRs New YORK CITY

Richard AXEL, MD Nobel Laureate Joseph GOLDSTEiN Nobel Laureate Tara NARULA, MD, FACC Co-director, Kavli Institute for Brain Science, Professor of Molecular Genetics and Internal Medical Contributor, CBS This Morning Columbia University Medical Centre Medicine, UT, Southwestern Medical Center at Guido RASi Dallas Cori BARGMANN, PhD Executive Director, European Medicines Agency Rockefeller University Dr Alex GORSKY Michael ROSENBLATT, MD Chaiman and CEO, Johnson & Johnson Michael BLOOMBERG Chief Medical Officer, Flagship Ventures Former Mayor, City of New York Dr. Scott GOTTLiEB, MD Bengt SAMUELSSON, MD, PhD Nobel Laureate Former Commissioner, U.S. FDA Albert BOURLA, DVM, PHD, Former President, Karolinska Institute Chief Executive Officer, Pfizer Inc. Paul GREENGARD, PhD Nobel Laureate Former Chairman, Nobel Foundation Professor of Molecular and Cellular Michael S. BROWN Nobel Laureate George A. SCANGOS, PhD Neuroscience, Rockefeller University the Galien Forum, held every autumn at New York’s Professor of Molecular Genetics and Internal Chief Executive Officer, Vir Biotechnology, Inc. Topics debaTed aT previous Medicine, UT Southwestern Medical Center at William N. HAiT, MD, PhD Alexandria center for Life Sciences since 2010, offers Dr Morgan SHENG Dallas Global Head, Research and Development, forums include: Vice President, Neuroscience Genentech a full day of dynamic presentations and spirited Janssen Research & Development Dr Samantha BUDD Steven H. STEiN, MD discussions with top scientists and industry researchers Vice President, Neuroscience iMed, Margaret A. HAMBURG, MD • Cancer Immunotherapeutics Senior Vice President US Clinical Development who offer perspectives on the most significant AstraZeneca R&D Former Commissioner, U.S. Food and Drug • The Brain Initiative & Medical Affairs, Novartis Oncology US Administration challenges in the global burden of disease and Rory COLLiNS • Personalized Medicine’s Impact on Drug R&D Marc TESSiER-LAViGNE, PhD Co-director, University of Oxford Clinical Trials Eric R. KANDEL, MD Nobel Laureate highlights the latest research and clinical pathways President, Stanford University and Patient Care Unit Professor of Physiology and Cellular Biophysics, toward diagnosis, treatment, and cure. Columbia University; Director Bio-technology Eric TOPOL, MD • Improving Efficiency in Drug Development Sue DESMOND-HELLMANN, MD, MPh, Study Center, NYU School of Medicine Director & Founder, Scripps Research Prix Galien USA Committee • What is “Value” and How Can it be Measured Translational Institute; Author, Deep Learning Our 700 attendees represent the top executive and thought and Demonstrated in Therapeutic Innovations? Former Chief Executive Officer, Sachin H. JAiN, MD, MBA leadership from academic research, industry, government, Bill & Melinda Gates Foundation Chief Medical information and innovation officer, P. Roy VAGELOS, MD • U.S. Health Reform Merck and Co.; Lecturer in Healthcare Policy Retired Chairman and CEO, Merck & Co., Inc.; the regulatory community, patient organizations, Mikael DOLSTEN, MD, PhD Harvard Medical School Chairman of the Board, Regeneron • A New Agenda for Global Health President, Worldwide Research and international organizations, and the media. Time and again, Pharmaceuticals John LECHLEiTER Forum participants praise the caliber of the speakers and • The Future of Digital Health and its Impact Development, Pfizer Chairman and CEO, Eli Lilly & Company Bert VOGELSTEiN Ezekiel EMANUEL, MD, PhD their fellow attendees, the quality of the panel discussions on Healthcare Professor, Johns Hopkins Medical School and presentations, and the recognition of industry’s critical Vice Provost for Global Initiatives;Chair, Dr Jeffrey LEiDEN • New Mechanisms for Industry-Academia Dept. of Medical Ethics and Health Policy Levy; Chairman, President and CEO, Vertex Christophe WEBER, PharmD role in creating life-saving innovations. Collaboration University Professor Perelman School of Representative Director, President & Chief Donald LLOYD-JONES Medicine and The Wharton School, University of Executive Officer, Takeda Pharmaceutical • The Future of Targeted Drug Delivery Chairman, Department of Preventive Medicine, These events represent peer-to-peer exchange with a public Pennsylvania Company Limited • Microbiota in Human Disease Northwestern University purpose, featuring unique opportunities to connect with a Jacqualyn FOUSE, PhD George YANCOPOULOS, MD, PhD Joel S. MARCUS diverse range of people, organizations and interests from • Autism - The Next Decade Chief Executive Officer, Agios Chief Scientific Officer, Regeneron Chairman, CEO & Founder, Alexandria Pharmaceuticals; President, Regeneron professional and scientific groups, academia, governmental • Untangling the Web of Neurodegeneration Kenneth C. FRAziER Real Estate Equities / Alexandria Venture organizations and patient associations, non-profit Laboratories • Precision Medicine: Delivering on the Promise Chaiman, CEO and President, Merck Investments; Co-Founder Alexandria Summit Krishna YESHWANT, MD organizations and the media. Maria C. FREiRE, PhD Mark McCLELLAN, MD, PhD Molecular Scissors: What Can We General Partner, Google Ventures Expect from Gene Editing? President & Executive Director, Foundation for Director, Duke-Robert J. Margolis Center for the National Institutes of Health Health Policy; Professor of Business, Medicine, Elias zERHOUNi and Health Policy, Duke University Former President, Global R&D, Sanofi Laurie GLiMCHER, MD CEO and President Dana Farber Cancer Institute; Dr ira MELLMAN Professor of Medicine, Harvard Medical School Vice President, Genentech 6 7 PRix Galien A REcoRd of lEAdERSHIP In bRIngIng THE bEST of bIomEdIcAl dIScoVERy To THE ATTEnTIon of THE woRld

“I welcome you to the annual Prix “I know the importance of the Prix Galien “The Prix Galien since 1970 is dedicated Galien awards for innovative excellence which rewards every year therapeutic to promoting the research in biomedical products and health innovations and research works among and development of the medicine “The Prix Galien is a welcome technologies. The awards are among “I am particularly grateful the most creative.“ and medicine industries.“ initiative to stimulate creative the highest honors in science and to receive this Award.“ research and promote excellence.“ commerce..“ Emmanuel Macron Macky Sall Bill Clinton “I’d also like to congratulate all the French President - 2018 Senegalese President - 2018 Barack Obama Jimmy Carter American President - 2010 candidates for the 5th Annual Prix Galien American President - 2008 American President - 2017 Awards Competition, which honors those in the pharmaceutical industry who have developed the technical, scientific and clinical research skills necessary to develop innovative medicines and devices. Your work is invaluable.“ Margaret A. Hamburg, M.D. Commissioner of Food and Drugs US Food and Drug Administration - 2011 “I look forward to the day when we will celebrate an African winner “I applaud Prix Galien for recognizing “We recognize the importance of the “The Prix Galien USA recognizes the of the Prix Galien.“ “The Prix Galien Awards are a true the pioneering spirit of America Prix Galien in promoting drug research, important research necessary to develop celebration of the years of hard work innovation and research.“ and we salute the excellent work innovative medicines and devices that Tedros Adhanom Ghebreyesus that are required to produce lifechanging of the Jury.“ have a life-saving impact on individuals Director-General, interventions.“ John McCain World Health Organization - 2018 American Senator - 2008 Philippe Douste-Blazy and families across the globe.“ Bill & Melinda Gates - 2018 French Minister of Foreign Affairs – 2006 Kathleen Sebelius American Secretary of Health and Human Services - 2011

“When Olympic rhymes with Galenic: there is a gold medal that can be won for an extraordinary achievement: this is the Galien Award, the Oscar of pharmaceutical research.“ “The Prix Galien is the right event, on Walter Sutter the right issue at the right time. I thank “The Prix Galien is a prestigious award, Swiss State Advisor, Director “The Galien Foundation, created to honor the Galien Foundation for bringing us a magnificent occasion to pay of the Public Economy - 2004 and catalyze excellence in scientific together and for recognizing that “Prix Galien recognizes men and women recognition to our researchers and innovation, recognizes outstanding “It is a pleasure to congratulate all those who a healthier world is a safer world and from the pharmaceutical and biomedical to encourage our industry.“ achievement with the prestigious Prix promote the Prix Galien and pharmaceutical a more just world.“ industries whose contributions of Galien Award.“ Jean Chretien research: they play a vital role in the fight BAN Ki-moon science have improved and saved against disease throughout the world.“ countless lives.“ Canadian Prime Minister - 1994 Bill De Blasio UN Secretary-General - 2010 Mayor of the City of New York - 2015 John Major Michael Bloomberg 8 British Prime Minister - 1996 Mayor of the City of New York - 2010 9 PRix Galien Galien aWaRds OCTObeR 29TH, 2O20 6:3O Pm AMERICAN MUSEUM OF NATURAL HISTORY hall of Fame cEREmony 2o2o NEW YORK CITY Around the globe since 1970

BY NUMBER OF MEDALS Summary of past 50 years of Prix Galien awards

COMPANY MEDALS COMPANY MEDALS COMPANY MEDALS MERCK&CO 63 ASTELLAS 2 GENERIUM 1 NOVARTIS 56 CHUGAI PHARMA 2 GUERBET 1 ROCHE 49 CTRS 2 INSIGHTEC 1 GSK 40 EDWARDS LIFESCIENCES 2 INSTITUT STUCHU 1 PFIZER 33 FRESENIUS BIOTECH 2 INTERCEPT PHARMACEUTICALS 1 SANOFI 31 IPSEN 2 IONIS PHARMACEUTICALS 1 J&J - JANSSEN 29 MEDTRONIC 2 LEO 1 BMS 22 PIERRE FABRE 2 LFB 1 AMGEN 20 PTC THERAPEUTICS 2 LIFEINA 1 BAYER 14 ROEHM-PHARMA 2 MENARINI 1 BOEHRINGER INGELHEIM 12 SIEMENS 2 NEW YORK BLOOD CENTER SERVIER 11 SYSMEx 2 HOWARD MILSTEIN 1 BIOGEN 10 AFA CROHN RCH FRANCE 1 NORGINE GMBH 1 GILEAD SCIENCES 9 ALBANA PHARMA 1 PHARMAPHARM 1 ABBOTT 7 ALNYLAM NETHERLANDS BV. 1 RECORDATI PHARMA 1 Our annual gala awards dinner is a creative recognition of the productive and positive power of partnerships that SMITH & NETHEW 1 ASTRAZENECA 7 AMICUS 1 drive progress in medical science. It is peer exchange with a public purpose - with a diverse range of opportunities TAKEDA 7 ASTA PHARMA 1 SOFMEDICA 1 for contact with a range of interests, from professional and scientific groups, academia and governments to patient VERTEx PHARMACEUTICALS 7 BAxTER 1 SPARK THERAPEUTICS 1 ELI LILLY 5 BD 1 STRYKER 1 associations, other non-profit organizations and the media. MERCK KGAA 5 BIOCARTIS 1 SVR 1 CHIESI 4 BIOCHEM-PHARMA 1 SWEDISH ORPHAN LUNDBECK 4 BIOCODEx 1 INTERNATIONAL 1 AAZ-LMB 3 EDAP TMS 1 SYADEM - GROUPE D’ETUDES wHaT PRevIOus ACTELION 3 EOS SAS 1 EN PRÉVENTOLOGIE 1 PRIX galIeN wINNeRs “Merck’s mission is to trans- “Our 2016 Prix Galien USA ALExION 3 ExACT SCIENCES 1 T2 BIOSYSTEMS 1 Have saId uPON late science into medically awards [for Cosentyx and BOSTON SCIENTIFIC 3 FACULTY OF PHARMA ANGERS 1 URGO MEDICAL 1 important products that positively impact Gleevec] … represent years of hard work TEVA 3 FERRER 1 VIRON THERAPEUTICS 1 ReCeIvINg humanity, so it is natural for us to support by our scientists. These wins underscore ABBVIE 2 FISONS 1 THe HONOuR the Prix Galien, since it supports exactly our commitment to addressing the unmet ALMIRALL 2 FROSST 1 Updated January 2020 that.” medical needs of patients through sci- Kenneth C. Frazier ence-based innovation.” Chaiman, CEO and President, Merck Joseph Jimenez, CEO, Novartis

the Medal by AlbERT dE JAEgER “The Galien Foundation “Our 2016 Prix Galien award “Our goal — to combine the brings together the top highlights not only the break- best science with the most The Prix Galien medal was designed by Albert de Jaeger (1908 – 1992), laureate of the Premier Grand Prix de scientists in the world. You have Nobel through science behind Cologuard, but efficient drug development plan and Rome architectural prize. De Jaeger designed medals for prominent figures such as Pope PiusII x (at the Laureates across the spectrum of scien- also the unrivaled team that worked to deliver transformational medicines to Villa Medicis, 1937) and Pope Jean-Paul I, Presidents Dwight D. Eisenhower and John F. Kennedy, tific disciplines meeting and talking with develop and bring to market an innova- patients in need — is completely aligned distinguished military leaders including Marshals Leclerc, Koenig, Montgomery, Marshall and Joukov; members of the pharmaceutical indus- tion with the potential to make a signifi- with the Galien Foundation mission to the Weizmann Institute, as well as numerous artists, literary figures and prominent personalities try to see what’s going on at the cutting cant impact in eradicating colorectal can- promote innovations that improve the such as Sacha Guitry, Marcel Proust, Henri de Montherlant, Paul Harris, a number of Nobel Prize edge, because ultimately that’s going to cer. We are humbled and thankful to be human condition.” laureates, the Empress of Iran SA Farah Diba, Princess Grace of Monaco, and others… benefit patients.” counted among the companies honored Mace L. Rothenberg, MD by the Galien Foundation.” De Jaeger is also the architect of numerous outstanding monuments in France and William Hait, MD, PhD Chief Development Officer, Oncology, throughout the world. Global Head, Research & Development, Graham Lidgard, PhD Pfizer Global Product Development Janssen, Pharmaceutical Companies of Chief Science Officer, Exact Sciences Johnson & Johnson 10 11 2OO9 2O15 bArrY bLOOM AND Pr. MArY-cLAIre kING JeFFreY SAcHS Professor, Genome Sciences and Medical Professor of Public Health, Harvard University; PRo Bono Genetics, University of Washington Director, Earth Institute, Columbia University hUManUM aWaRd In recognition of her work in transforming Harvard Professor Barry Bloom for bringing the fruits of basic the application of human genetics to medicine through biological science to those who are most needy. Columbia identification of the first gene, BRCA1, responsible for University Earth Institute Director Jeffrey Sachs for bringing The committee follows a century-old example set in Sweden. inherited susceptibility to breast cancer. And for pioneering the fruits of scholarly economics to bear our problems that The Prix Galien rewards excellence and novelty, and awards special the application of genetic sequencing in forensics to identify have plagued the world for millennia. honors to those who have served humanity at large. Presented at the victims of human rights abuse. Ceremony, the Pro Bono Humanum Award recognizes exemplary and innovative efforts in improving the human condition. This special 2OO8 PRix Galien Usa 2O14 SHeLDON SeGAL AND tHe award was presented by the late and beloved Elie Wiesel, in presence Galien FoUndation Dr. berNArD kOucHNer POPuLAtION cOuNcIL of the Prix Galien USA Committee. Co-Founder, Doctors Without Border & Former Chairman, Population Council The Pro Bono Humanum Award was renamed the Roy Vagelos Pro Bono Former French Minister of Foreign and Humanum Award in 2017 in recognition of his decades of leadership European Affairs For their global efforts in support of reproductive health and An UnRIVAlEd REPUTATIon in improving the state of human health through medicines innovation. family planning. In recognition of his role in the creation, from amongst French foR InTEllEcTUAl RIgoR doctors, this group of “Doctors Without Borders” who have lent the modern field of humanitarian medicine both legitimacy and 2OO7 And InTEgRITy… 2O19 worldwide acclaim and for his fieldwork that has nurtured and P. rOY VAGeLOS developed, not only among public opinion but also within various Retired Chairman and CEO JIM AND MArILYN SIMONS Photo: governments, the notion of the universality of humanitarian Merck & Co., Inc.; The Simons Foundation Tony Lopez action and the concept of the Non-Governmental Organization. Chairman of the Board In recognition of their proactive support of basic scientific research Regeneron Pharmaceuticals, Inc. undertaken in the pursuit of understanding the phenomena of our 2O13 For the River Blindness Program and his historic decision to world, often including research by scientists in the early stages of donate the drug Mectizan to more than 530 million people in Dr. ANtHONY FAucI their careers, a new collaborative funding model to facilitate cross- 34 countries to treat and prevent river blindness “as much as Director, U.S. National Institute of disciplinary breakthroughs, and efforts to inspire emerging and necessary for as long as necessary.” current philanthropists to dedicate a portion of their philanthropy to Allergy and Infectious Diseases basic science. For his paramount contributions to basic and clinical research on the pathogenesis and treatment of immune Who Was Galien? mediated and infectious diseases. 2O18 Born in 131AD, Galien is considered the father of modern medicine bILL AND MeLINDA GAteS 2O12 and pharmacology. As an anatomist, physiologist, clinician and Bill & Melinda Gates Foundation researcher, his work formed the basis of a school of thought known Dr. FrANcIS S. cOLLINS In recognition of their extraordinary work as “Galenism”, which dominated medicine until the Renaissance. In championing scientific and technological innovation to improve life Director, U.S. National Institutes of Health fact, Galen’s works were used as primary medical reference for nearly for the world’s poorest people. As co-chairs of the Bill & Melinda Dr. Collins, Director of the National Institutes two centuries. Gates Foundation, they have catalyzed unprecedented progress in of Health (N.I.H). In recognition of his contribution Raised in Pergamos, he studied in Smyrna, Corinth, and Alexandria, global health, poverty reduction, and public education in the U.S. to the ethical implications of scientific research. the three centers of medical excellence in the ancient world. Legend Elie Wiesel, Peace Nobel Laureate; has it that Galen was visited by Aesclapius in a dream and that this BAN Ki-moon, General Secretary, United Nations; 2O17 2O11 inspired the direction of his life. When he was 17, Galen worked as a Bill Clinton & Philippe Douste-Blazy, 2010 Prix Galien Pro Bono Humanum Award Laureate JIMMY cArter Pr. PAuL FArMer physician to the gladiatorial school. At the age of 37, Marcus Aurelius summoned him to Rome, where he grew in reputation and stature as Former U.S. President & Co-Founder, Chief Strategist and Co-Founder, a healer, teacher, researcher and writer. His ideas on the functioning The Carter Center Partners In Health of the human body were so well received that he became the personal The prix Galien usa committee, a group of highly For playing a leadership role in the elimination of river For his humanitarian work in Haiti and doctor of young Commodus, the heir to the Emperor. He died in accomplished individuals from the scientific and blindness in four of the six Latin American countries where it was throughout the world, including advancing the fight against 201AD. During his long and eminent career, Galen completed over research communities, will judge which among endemic and halting the disease’s transmission in several locations infectious diseases, including AIDS and . 500 learned works addressing anatomy, physiology, pathology, the candidates, independent of any category, in Africa where more than 99 percent of the global cases exist. medical theory and practice, and many forms of therapy. He traveled is the best pharmaceutical agent (i.e. small 2O1O throughout the world, studying local plants and remedies, eventually molecule), the best biotechnology product and describing 473 original drugs and many substances of mineral and 2O16 bILL cLINtON AND the best medical Technology approved by the vegetable origin. Importantly, Galen was the first to codify the art of PAuLA S. APSeLL PHILIPPe DOuSte-bLAzY fda in the past five years. as few as one or as preparing active drugs using multiple ingredients. Galen’s faculties Executive Producer, PBS NOVA series & Founder, Clinton Foundation and Former of observation, logic and deduction made him the true successor of many as three prizes may be awarded in each of Director, Science Unit, WGBH U.S. President; Chairman, UNITAID Hippocrates, and his declaration that the primary aim of medicine these categories, and the committee may decide For turning great science into a human story, In recognition of their achievements in providing treatment and was patient care formed the very cornerstone of modern pharmacy. on awards hors prix. The prizes are awarded for showing that scientific literacy is society’s first line of increasing access to medicines for underserved populations To quote Jean-Pierre Changeux, “Galen first showed that our mind products and agents that significantly improve defense against the destructive forces of fear and ignorance that through the UNITAID and Clinton Foundation HIV/AIDS Initiative was in the brain, not in our hearts.” It can be said that this was the the human condition. challenge further progress in human health. (CHAI) partnership. beginning of experimental medicine. 12 13 PRix Galien Usa WinneRs aNd IN 2O2O, THe wINNeRs aRe…

the mission of the Prix Galien-MedStartup program is to foster private-sector collaborations to treat and cure medical conditions that pose a threat to public health worldwide and promotes foster innovative research partnerships PRix Galien among major integrated pharmaceutical companies, biotech firms, and medical device manufacturers, producers of vaccines, academic research institutes, MedstartUp and health care organizations, including e-health vendors.

This unique initiative, which takes place in the same venue eAcH YeAr tHe JurY NOMINAteS cANDIDAteS FOr and at the same time as the Galien Forum, was built on FOur AWArDS IN tHe FOLLOWING cAteGOrIeS: several years of cooperation between the Galien Foundation and Business France with three core goals: • Best Collaboration in the Pharmaceutical or Biotechnology industry • Strengthen commercial partnerships that bridge the traditional silos between government, industry and academia; • Best Collaboration in the Medtech or Digital Health sector 2O19 2O18 • Best Pharmaceutical Product: SHINGRIX, GlaxoSmithKline • Best Pharmaceutical Product: IDHIFA®, Celgene Agios • Defray the growing complexity and cost burden of • Best Collaboration dedicated to the developing or • Best Biotechnology Product: LUXTURNA™, Spark Therapeutics • Best Biotechnology Product: Yescarta®, Kite, a Gilead Company medicines R&D; underserved populations worldwide • Best Medical Technology: FreeStyle® Libre 14 Day Flash & Kymriah®, Novartis Pharmaceuticals Corporation • Promote cross-border trade, jobs, and economic growth. Glucose Monitoring System, Abbott • Best Medical Technology: WATCHMANTM, Boston Scientific Corporation • Pro Bono Humanum Award: Jim and Marilyn Simons, • Pro Bono Humanum Award: Bill and Melinda Gates. A focal point of the program is the active participation of the The Simons Foundation Co-Chairs, Bill & Melinda Gates Foundation most innovative start-up companies who are seeking US partners to share research and support global commercial development of promising lead technologies. 2O17 2O16 2O15 Discovery • Best Pharmaceutical Product: • Best Pharmaceutical Agent: • Best Pharmaceutical Agent: of the Decade Venclexta™, AbbVie & Genentech Ibrance®, Pfizer, Inc. IMBRUVICA®, Janssen Biotech, • Best Pharmaceutical Agent: ® (a Member of the Roche Group) • Best Biotechnology Product: Inc. & Pharmacyclics LLC, Gleevec , Novartis • Best Biotechnology Product: Cosentyx®, Novartis an AbbVie Company • Best Biotechnology Product: Chairman: Bernard POUSSOT ® ® SPINRAZA , Biogen & Ionis • Best Medical Technology: • Best Biotechnology Product: Yervoy , Bristol-Myers Squibb Director, Roche Holding, ® Pharmaceuticals Cologuard®, Exact Sciences OPDIVO , Bristol-Myers Squibb • Best Medical Technology: Former Chairman & CEO, WYETH ® • Best Medical Technology: KEYTRUDA , Merck & Co., Inc. Sapien 3TM, Edwards Lifesciences THE JURY Exablate Neuro, INSIGHTEC • Best Medical Technology: • Pro Bono Humanum Award: • Pro Bono Humanum Award: T2Candida Panel, T2 Biosystems, Inc. Paula S. Apsell Former President Jimmy Carter • Pro Bono Humanum Award: Pr. Mary-Claire King Roch DOLiVEUX Honorary CEO, 2O14 2O13 2O12 2O11 UCB François MAiSONROUGE • Best Pharmaceutical Agent: • Best Pharmaceutical Agents: • Best Pharmaceutical Agents: • Best Pharmaceutical Agent: Senior Managing Director, Sovaldi® - Gilead Sciences Zelboraf® - Genentech Victrelis® - Merck & Co., Inc.; Prevnar13® - Pfizer ® Evercore Partners • Best Biotechnology Product: • Best Biotechnology Product: Incivek - Vertex Pharmaceuticals • Best Biotechnology Product: HEMACORD® - The New York Zostavax® - Merck & Co., Inc. • Best Biotechnology Product: Stelara® - Janssen Mikael DOLSTEN Blood Center’s Howard Yervoy® - Bristol-Myers Squibb Prolia and XGEVA® - Amgen Global R&D President, • Best Medical Technology product: P. Milstein Cord Blood Center S-ICD® System - Boston Scientific • Best Medical Technology product: • Pro Bono Humanum Award: Pfizer ® Paul STOFFELS • Best Medical Technology: • Pro Bono Humanum Award: Sapien -Edwards Lifesciences Paul Farmer ® ® Chief Scientific Officer, Trevo ProVue - Stryker Dr. Anthony S. Fauci Melody -Medtronic Johnson and Johnson • Pro Bono Humanum Award: • Pro Bono Humanum Award: Dr. Bernard Kouchner Dr. Francis S. Collins Jean-Pierre GARNiER Former CEO, 2O1O 2OO9 2OO8 2OO7 GSK Elias zERHOUNi • Best Pharmaceutical Agent: • Best Pharmaceutical Agent: • Best Pharmaceutical Agent: • Best Pharmaceutical Agent: Global R&D President, Coartem® - Novartis Gleevec® - Novartis Isentress® - Merck & Co., Inc.; Januvia® - Merck & Co., Inc.; Sanofi ® ® • Best Biotechnology Product: • Best Biotechnology Product: Selzentry - Pfizer Chantix - Pfizer ® ® Franz HUMER RotaTeq - Merck & Co., Inc. Nplate - Amgen; • Best Biotechnology Product: • Best Biotechnology Product: ® ® ® ® • Best Medical Technology: Promacta - GlaxoSmithKline Soliris - Alexion; Infuse - Wyeth Humira - Abbott; Former CEO, ® ® Gardasil - Merck & Co., Inc. Roche xTAG -Luminex Corporation • Best Medical Technology: • Special therapeutic development: ® ® • Pro Bono Humanum Award: Cellsearch - Veridex (J&J) Revlimid - Celgene • Pro Bono Humanum Award: Bill Clinton and • Pro Bono Humanum Award: • Pro Bono Humanum Award: Dr. Roy Vagelos JOIN us ON : Philippe Douste-Blazy Jeffrey Sachs and Barry Bloom Sheldon Segal http://medstartup.galienfoundation.org + 14 15 14 OCTObeR 29, 2O2O / AMerIcAN MuSeuM OF NAturAL HIStOrY

And THE 2o2o wInnER IS?

The Prix Galien Award recognizes actoRs Win outstanding achievements in improving oscaRs the global human condition through ... the development of innovative drugs and other treatments. innovatoRs Win PRix Galien Usa The Prix Galien was created in 1970 in honor of Galien, the father of medical science and modern pharmacology.

Worldwide, the Prix Galien is regarded hall oF as the equivalent of the Nobel Prize 2019 SHINGRIX / LUXTURNA™ 2019 in biopharmaceutical research. FaMe FreeStyle® Libre

® ® ® 2018 IDHIFA / Yescarta / Kymriah 2018 Watchman™ Left Atrial Appendage Closure Device

Exablate Neuro® 2017 Spinraza® / VenclextaTM 2017

2016 Cologuard® / Cosentyx® / Ibrance® 2016

® ® ® 2015 Imbruvica / Keytruda / Opdivo 2015 T2Candida Panel

2014 HemacordTM / Trevo®ProVueTM / Sovaldi® 2014 2013 S-ICD® System / Zelboraf® / Zostavax® 2013

2012 Prevnar13® / Prolia and XGEVA® / Stelara® 2012 2011 Incivek® / Melody® / Sapien® / Victrelis® Yervoy® 2011 2010 Coartem® / Rotateq® / xTAG® 2010 2009 Cellsearch® / Gleevec® / Nplate® / Promacta® 2009 2008 Infuse® / Isentress® / Revlimid®/ Selzentry® / Soliris® 2008 2007 Chantix® / Gardasil® / Humira® / Januvia® 2007

The Galien Foundation 99 John Street, Suite 2502 / New York, NY 10038 Tel: 212-685-1592 www.galienfoundation.org