Pushing Estrogen Receptor Around in Breast Cancer
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Androgen Receptor: a Complex Therapeutic Target for Breast Cancer
cancers Review Androgen Receptor: A Complex Therapeutic Target for Breast Cancer Ramesh Narayanan 1 and James T. Dalton 2,* 1 Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38103, USA; [email protected] 2 College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA * Correspondence: [email protected] Academic Editor: Emmanuel S. Antonarakis Received: 28 September 2016; Accepted: 23 November 2016; Published: 2 December 2016 Abstract: Molecular and histopathological profiling have classified breast cancer into multiple sub-types empowering precision treatment. Although estrogen receptor (ER) and human epidermal growth factor receptor (HER2) are the mainstay therapeutic targets in breast cancer, the androgen receptor (AR) is evolving as a molecular target for cancers that have developed resistance to conventional treatments. The high expression of AR in breast cancer and recent discovery and development of new nonsteroidal drugs targeting the AR provide a strong rationale for exploring it again as a therapeutic target in this disease. Ironically, both nonsteroidal agonists and antagonists for the AR are undergoing clinical trials, making AR a complicated target to understand in breast cancer. This review provides a detailed account of AR’s therapeutic role in breast cancer. Keywords: androgen receptor; breast cancer; selective androgen receptor modulator (SARM); estrogen receptor; triple-negative breast cancer (TNBC) 1. Introduction Over 240,000 women will develop breast cancer and ~40,000 will die from the disease in the United States in 2016 [1]. Globally, about 1.7 million women were diagnosed with breast cancer in 2012, emphasizing the urgent need for effective and safe therapeutic approaches [2]. -
Cancer Palliative Care and Anabolic Therapies
Cancer Palliative Care and Anabolic Therapies Aminah Jatoi, M.D. Professor of Oncology Mayo Clinic, Rochester, Minnesota USA • 2 Androgens • Creatine • Comments von Haehling S, et al, 2017 Oxandrolone: androgen that causes less virilization oxandrolone RANDOMIZE megestrol acetate #1: Oxandrolone (Lesser, et al, ASCO abstract 9513; 2008) • N=155 patients receiving chemotherapy • oxandrolone (10 mg twice a day x 12 weeks) versus megestrol acetate (800 mg/day x 12 weeks) • oxandrolone led to – a non-statistically significant increase in lean body mass (bioelectrical impedance) at 12 weeks (2.67 versus 0.82 pounds with megestrol acetate, p = 0.12), but – a decrease in overall weight as compared with megestrol acetate (-3.3 versus +5.8 pounds, respectively). • more oxandrolone patients dropped out prior to completing 12 weeks (63% versus 39 %). #2: Oxandrolone (von Roenn, et al, ASCO, 2003) • N=131 • Single arm • 81% of patients gained/maintained weight • Safe (PRIMARY ENDPOINT): 19% edema; 18% dyspnea; mild liver function test abnormalities #3: Oxandrolone: placebo controlled trial • results unknown SUMMARY OF OXANDROLONE: • Multiple studies (not yet peer-reviewed) • Hints of augmentation of lean tissue • High drop out in the phase 3 oxandrolone arm raises concern Enobosarm: selective androgen receptor modulator (less virilizing) ENOBOSARM RANDOMIZE* PLACEBO *All patients had non-small cell lung cancer, and chemotherapy was given concomittantly. percentage of subjects at day 84 with stair climb power change >=10% from their baseline value percentage of subjects at day 84 with lean body mass change >=0% from their baseline value SUMMARY OF ENOBOSARM: • Leads to incremental lean body mass, but functionality not demonstrated • Pivotal registration trial (not yet peer- reviewed (but FDA-reviewed….)) • 2 Androgens • Creatine • Comments Creatine: an amino acid derivative This study was funded by R21CA098477 and the Alliance for Clinical Trials NCORP grant. -
UFC PROHIBITED LIST Effective June 1, 2021 the UFC PROHIBITED LIST
UFC PROHIBITED LIST Effective June 1, 2021 THE UFC PROHIBITED LIST UFC PROHIBITED LIST Effective June 1, 2021 PART 1. Except as provided otherwise in PART 2 below, the UFC Prohibited List shall incorporate the most current Prohibited List published by WADA, as well as any WADA Technical Documents establishing decision limits or reporting levels, and, unless otherwise modified by the UFC Prohibited List or the UFC Anti-Doping Policy, Prohibited Substances, Prohibited Methods, Specified or Non-Specified Substances and Specified or Non-Specified Methods shall be as identified as such on the WADA Prohibited List or WADA Technical Documents. PART 2. Notwithstanding the WADA Prohibited List and any otherwise applicable WADA Technical Documents, the following modifications shall be in full force and effect: 1. Decision Concentration Levels. Adverse Analytical Findings reported at a concentration below the following Decision Concentration Levels shall be managed by USADA as Atypical Findings. • Cannabinoids: natural or synthetic delta-9-tetrahydrocannabinol (THC) or Cannabimimetics (e.g., “Spice,” JWH-018, JWH-073, HU-210): any level • Clomiphene: 0.1 ng/mL1 • Dehydrochloromethyltestosterone (DHCMT) long-term metabolite (M3): 0.1 ng/mL • Selective Androgen Receptor Modulators (SARMs): 0.1 ng/mL2 • GW-1516 (GW-501516) metabolites: 0.1 ng/mL • Epitrenbolone (Trenbolone metabolite): 0.2 ng/mL 2. SARMs/GW-1516: Adverse Analytical Findings reported at a concentration at or above the applicable Decision Concentration Level but under 1 ng/mL shall be managed by USADA as Specified Substances. 3. Higenamine: Higenamine shall be a Prohibited Substance under the UFC Anti-Doping Policy only In-Competition (and not Out-of- Competition). -
Curriculum Vitae
Professor Barry V L Potter Publications (1979 - 2015) Papers in refereed journals, patents, reviews and book chapters JOURNAL PAPERS 1. The effect of 17O and the magnitude of the 18O isotope shift in 31P nuclear magnetic resonance spectroscopy. G Lowe, B V L Potter, B S Sproat and W E Hull, J Chem Soc Chem Commun (1979) 733- 735. 2. Bacteriostatic properties of fluoro-analogues of 5(2-hydroxyethyl)-4-methyl thiazole, a metabolic intermediate in thiamine biosynthesis. G Lowe and B V L Potter, J Chem Soc Perkin Trans I (1980) 9, 2026-2028. 3. The synthesis, absolute configuration and circular dichroism of the enantiomers of fluorosuccinic acid. G Lowe and B V L Potter, J Chem Soc Perkin Trans I (1980) 9, 2029-2032. 4. Evidence against a step-wise mechanism for the fumarase-catalysed dehydration of (2S)- malate. V T Jones, G Lowe and B V L Potter, Eur J Biochem (1980) 108, 433-437. 5. A stereochemical investigation of the cyclisation of D-glucose-6[16O,17O,18O]-phosphate and adenosine 5'[16O,17O,18O]-phosphate. R L Jarvest, G Lowe and B V L Potter, J Chem Soc Chem Commun (1980) 1142-1145. 6. The stereochemistry of phosphoryl transfer. G Lowe, P M Cullis, R L Jarvest, B V L Potter and B S Sproat, Phil Trans Roy Soc Lond Ser B (1981) 293, 75-92. 7. The stereochemistry of 2-substituted-2-oxo-4,5-diphenyl-1,3,2-dioxaphospholanes and the related chiral [16O,17O,18O]-phosphate monoesters. P M Cullis, R L Jarvest, G Lowe and B V L Potter, J Chem Soc Chem Commun (1981) 245- 246. -
Version Introducing VHIO Foreword
2017SCIENTIFIC REPORT Vall d'Hebron Institute of Oncology (VHIO) CELLEX CENTER C/Natzaret, 115 – 117 08035 Barcelona, Spain Tel. +34 93 254 34 50 www.vhio.net Direction: Amanda Wren Design: Parra estudio Photography: Katherin Wermke Vall d'Hebron Institute of Oncology (VHIO) | 2018 VHIO Scientific Report 2017 Index Scientific Report INTRODUCING VHIO CORE TECHNOLOGIES 02 Foreword 92 Cancer Genomics Group 08 2017: marking the next chapter of 94 Molecular Oncology Group VHIO's translational story 96 Proteomics Group 18 Scientific Productivity: research articles VHIO'S TRANSVERSAL CLINICAL 19 Selection of some of the most relevant TRIALS CORE SERVICES & UNITS articles by VHIO researchers published in 2017 100 Clinical Trials Office 25 A Golden Decade: reflecting on the 102 Research Unit for Molecular Therapy past 10 years of VHIO's translational of Cancer (UITM) – ”la Caixa” success story 104 Clinical Research Oncology Nurses 106 Clinical Research Oncology Pharmacy PRECLINICAL RESEARCH Unit 49 From the Director 50 Experimental Therapeutics Group RECENTLY INCORPORATED GROUPS 52 Growth Factors Group 110 Cellular Plasticity & Cancer Group 54 Mouse Models of Cancer Therapies 112 Experimental Hematology Group Group 114 Tumor Immunology 56 Tumor Biomarkers Group & Immunotherapy Group 116 Applied Genetics of Metastatic Cancer TRANSLATIONAL RESEARCH Group 61 From the Director 118 Chromatin Dynamics in Cancer Group 62 Gene Expression & Cancer Group 120 Prostate Cancer Translational Research Group 64 Stem Cells & Cancer Group 122 Radiomics Group CLINICAL -
Tanibirumab (CUI C3490677) Add to Cart
5/17/2018 NCI Metathesaurus Contains Exact Match Begins With Name Code Property Relationship Source ALL Advanced Search NCIm Version: 201706 Version 2.8 (using LexEVS 6.5) Home | NCIt Hierarchy | Sources | Help Suggest changes to this concept Tanibirumab (CUI C3490677) Add to Cart Table of Contents Terms & Properties Synonym Details Relationships By Source Terms & Properties Concept Unique Identifier (CUI): C3490677 NCI Thesaurus Code: C102877 (see NCI Thesaurus info) Semantic Type: Immunologic Factor Semantic Type: Amino Acid, Peptide, or Protein Semantic Type: Pharmacologic Substance NCIt Definition: A fully human monoclonal antibody targeting the vascular endothelial growth factor receptor 2 (VEGFR2), with potential antiangiogenic activity. Upon administration, tanibirumab specifically binds to VEGFR2, thereby preventing the binding of its ligand VEGF. This may result in the inhibition of tumor angiogenesis and a decrease in tumor nutrient supply. VEGFR2 is a pro-angiogenic growth factor receptor tyrosine kinase expressed by endothelial cells, while VEGF is overexpressed in many tumors and is correlated to tumor progression. PDQ Definition: A fully human monoclonal antibody targeting the vascular endothelial growth factor receptor 2 (VEGFR2), with potential antiangiogenic activity. Upon administration, tanibirumab specifically binds to VEGFR2, thereby preventing the binding of its ligand VEGF. This may result in the inhibition of tumor angiogenesis and a decrease in tumor nutrient supply. VEGFR2 is a pro-angiogenic growth factor receptor -
Anti-Cytokines in the Treatment of Cancer Cachexia
79 Review Article Anti-cytokines in the treatment of cancer cachexia Bernard Lobato Prado1, Yu Qian2 1Department of Oncology and Hematology, Hospital Israelita Albert Einstein, Sao Paulo, Brazil; 2Department of Thoracic Oncology, Hubei Cancer Hospital, Wuhan 430070, China Contributions: (I) Conception and design: All authors; (II) Administrative support: None; (III) Provision of study materials or patients: None; (IV) Collection and assembly of data: None; (V) Data analysis and interpretation: None; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. Correspondence to: Bernard Prado, MD. Department of Oncology and Hematology, Hospital Israelita Albert Einstein, Albert Einstein Av. 627, Sao Paulo 05652-900, Brazil. Email: [email protected]. Abstract: Cancer-related cachexia (CRC) is a multidimensional, frequent and devastating syndrome. It is mainly characterized by a loss of skeletal muscle tissue, accompanied or not by a loss of adipose tissue that leads to impaired functionality, poor quality of life, less tolerability to cancer-directed therapies, high levels of psychosocial distress, and shorter survival. Despite its clinical importance, there is a lack of effective pharmacological therapies to manage CRC. Pro-cachectic cytokines have been shown to play a critical role in its pathogenesis, providing the conceptual basis for testing anti-cytokine drugs to treat this paraneoplastic syndrome. The aim of this review was to examine the current evidence on anti-cytokines in the treatment of CRC. Several anti-cytokine agents targeting one or more molecules (i.e., TNF-alpha, IL-1 alpha, IL- 6, and others) have been investigated in clinical trials for the treatment of CRC, mainly in phase I and II studies. -
The Selective Androgen Receptor Modulator Gtx-024
J Cachexia Sarcopenia Muscle (2011) 2:153–161 DOI 10.1007/s13539-011-0034-6 ORIGINAL ARTICLE The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial James T. Dalton & Kester G. Barnette & Casey E. Bohl & Michael L. Hancock & Domingo Rodriguez & Shontelle T. Dodson & Ronald A. Morton & Mitchell S. Steiner Received: 20 April 2011 /Accepted: 11 July 2011 /Published online: 2 August 2011 # The Author(s) 2011. This article is published with open access at Springerlink.com Abstract resistance (P=0.013, 3 mg vs. placebo). The incidence of Background Cachexia, also known as muscle wasting, is a adverse events was similar between treatment groups. complex metabolic condition characterized by loss of Conclusion GTx-024 showed a dose-dependent improve- skeletal muscle and a decline in physical function. Muscle ment in total lean body mass and physical function and was wasting is associated with cancer, sarcopenia, chronic well tolerated. GTx-024 may be useful in the prevention obstructive pulmonary disease, end-stage renal disease, and/or treatment of muscle wasting associated with cancer and other chronic conditions and results in significant and other chronic diseases. morbidity and mortality. GTx-024 (enobosarm) is a nonste- roidal selective androgen receptor modulator (SARM) that Keywords Muscle wasting . Selective androgen receptor has tissue-selective anabolic effects in muscle and bone, modulator . Cachexia . Physical function . Lean body mass while sparing other androgenic tissue related to hair growth in women and prostate effects in men. -
Effect of Tamoxifen Or Anastrozole on Steroid Sulfatase Activity and Serum Androgen Concentrations in Postmenopausal Women with Breast Cancer
ANTICANCER RESEARCH 31: 1367-1372 (2011) Effect of Tamoxifen or Anastrozole on Steroid Sulfatase Activity and Serum Androgen Concentrations in Postmenopausal Women with Breast Cancer S.J. STANWAY1, C. PALMIERI2, F.Z. STANCZYK3, E.J. FOLKERD4, M. DOWSETT4, R. WARD2, R.C. COOMBES2, M.J. REED1† and A. PUROHIT1 1Oncology Drug Discovery Group, Section of Investigative Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, U.K.; 2Cancer Research UK Laboratories, Department of Oncology, Hammersmith Hospital, London W12 0NN, U.K.; 3Reproductive Endocrine Research Laboratory, University of Southern California, Keck School of Medicine, Women’s and Children’s Hospital, Los Angeles, CA, U.S.A.; 4Department of Biochemistry, Royal Marsden Hospital, London, SW3 6JJ, U.K. Abstract. Background: In postmenopausal women sulfate and dehydroepiandrosterone levels. Results: Neither estrogens can be formed by the aromatase pathway, which anastrozole nor tamoxifen had any significant effect on STS gives rise to estrone, and the steroid sulfatase (STS) route activity as measured in PBLs. Anastrozole did not affect which can result in the formation of estrogens and serum androstenediol concentrations. Conclusion: androstenediol, a steroid with potent estrogenic properties. Anastrozole and tamoxifen did not inhibit STS activity and Aromatase inhibitors, such as anastrozole, are now in serum androstenediol concentrations were not reduced by clinical use whereas STS inhibitors, such as STX64, are still aromatase inhibition. As androstenediol has estrogenic undergoing clinical evaluation. STX64 was recently shown properties, it is possible that the combination of an to block STS activity and reduce serum androstenediol aromatase inhibitor and STS inhibitor may give a therapeutic concentrations in postmenopausal women with breast cancer. -
REVIEW Steroid Sulfatase Inhibitors for Estrogen
99 REVIEW Steroid sulfatase inhibitors for estrogen- and androgen-dependent cancers Atul Purohit and Paul A Foster1 Oncology Drug Discovery Group, Section of Investigative Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK 1School of Clinical and Experimental Medicine, Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham B15 2TT, UK (Correspondence should be addressed to P A Foster; Email: [email protected]) Abstract Estrogens and androgens are instrumental in the maturation of in vivo and where we currently stand in regards to clinical trials many hormone-dependent cancers. Consequently,the enzymes for these drugs. STS inhibitors are likely to play an important involved in their synthesis are cancer therapy targets. One such future role in the treatment of hormone-dependent cancers. enzyme, steroid sulfatase (STS), hydrolyses estrone sulfate, Novel in vivo models have been developed that allow pre-clinical and dehydroepiandrosterone sulfate to estrone and dehydroe- testing of inhibitors and the identification of lead clinical piandrosterone respectively. These are the precursors to the candidates. Phase I/II clinical trials in postmenopausal women formation of biologically active estradiol and androstenediol. with breast cancer have been completed and other trials in This review focuses on three aspects of STS inhibitors: patients with hormone-dependent prostate and endometrial 1) chemical development, 2) biological activity, and 3) clinical cancer are currently active. Potent STS inhibitors should trials. The aim is to discuss the importance of estrogens and become therapeutically valuable in hormone-dependent androgens in many cancers, the developmental history of STS cancers and other non-oncological conditions. -
Patent Application Publication ( 10 ) Pub . No . : US 2019 / 0192440 A1
US 20190192440A1 (19 ) United States (12 ) Patent Application Publication ( 10) Pub . No. : US 2019 /0192440 A1 LI (43 ) Pub . Date : Jun . 27 , 2019 ( 54 ) ORAL DRUG DOSAGE FORM COMPRISING Publication Classification DRUG IN THE FORM OF NANOPARTICLES (51 ) Int . CI. A61K 9 / 20 (2006 .01 ) ( 71 ) Applicant: Triastek , Inc. , Nanjing ( CN ) A61K 9 /00 ( 2006 . 01) A61K 31/ 192 ( 2006 .01 ) (72 ) Inventor : Xiaoling LI , Dublin , CA (US ) A61K 9 / 24 ( 2006 .01 ) ( 52 ) U . S . CI. ( 21 ) Appl. No. : 16 /289 ,499 CPC . .. .. A61K 9 /2031 (2013 . 01 ) ; A61K 9 /0065 ( 22 ) Filed : Feb . 28 , 2019 (2013 .01 ) ; A61K 9 / 209 ( 2013 .01 ) ; A61K 9 /2027 ( 2013 .01 ) ; A61K 31/ 192 ( 2013. 01 ) ; Related U . S . Application Data A61K 9 /2072 ( 2013 .01 ) (63 ) Continuation of application No. 16 /028 ,305 , filed on Jul. 5 , 2018 , now Pat . No . 10 , 258 ,575 , which is a (57 ) ABSTRACT continuation of application No . 15 / 173 ,596 , filed on The present disclosure provides a stable solid pharmaceuti Jun . 3 , 2016 . cal dosage form for oral administration . The dosage form (60 ) Provisional application No . 62 /313 ,092 , filed on Mar. includes a substrate that forms at least one compartment and 24 , 2016 , provisional application No . 62 / 296 , 087 , a drug content loaded into the compartment. The dosage filed on Feb . 17 , 2016 , provisional application No . form is so designed that the active pharmaceutical ingredient 62 / 170, 645 , filed on Jun . 3 , 2015 . of the drug content is released in a controlled manner. Patent Application Publication Jun . 27 , 2019 Sheet 1 of 20 US 2019 /0192440 A1 FIG . -
The Long and Winding Road for Selective Androgen Receptor Modulators
British Journal of Clinical Br J Clin Pharmacol (2017) 83 2131–2133 2131 Pharmacology COMMENTARY The long and winding road for selective androgen receptor modulators Correspondence James T Dalton, University of Michigan College of Pharmacy, 428 Church Street, Ann Arbor, MI 48109, USA. E-mail: [email protected] Received 24 April 2017; Accepted 7June2017 James T. Dalton University of Michigan College of Pharmacy, Ann Arbor,MI, USA Keywords clinical trials, drug development, lung cancer, oncology, phase I, statistics and study design Numerous selective androgen receptor modulators (SARMs) with differing chemical structures and nearly ideal pharmacological and pharmacokinetic properties have been developed that are well tolerated and selectively increase lean body mass in humans. However, definitive demonstration of the linkage between lean body mass and physical function in a relevant, large patient population has remained elusive for a SARM. The clinical endpoints serving as their basis of approval have shifted with time and clinical indication and are likely to continue to do so as the field matures with additional safety and efficacy data pertaining to the relationship between lean body mass and physical function, regulatory decisions with SARMs and other agents, and yet unexplored clinical indications. Clark et al. present results from phase I studies conducted and strength, bone growth and libido, with lesser but stim- with GSK2881078, a member of a new class of drugs known ulatory effects on the prostate, seminal vesicles and other as selective androgen receptor modulators (SARMs) [1]. sex accessory tissues. SARMs with varying chemical scaffolds and diverse pharma- Like other SARMs ahead of it in development, cological properties have emerged since initial reports of their GSK2881078 appears to meet most of these criteria.