Pathogen-Mediated Manipulation of Arthropod Microbiota to Promote Infection
Pathogen-mediated manipulation of arthropod PNAS PLUS microbiota to promote infection Nabil M. Abrahama,b,1, Lei Liua,1,2, Brandon Lyon Jutrasb,c,d, Akhilesh K. Yadave, Sukanya Narasimhana, Vissagan Gopalakrishnana,b,f, Juliana M. Ansarig, Kimberly K. Jeffersonh, Felipe Cavae, Christine Jacobs-Wagnerb,c,d,i, and Erol Fikriga,b,i,2 aSection of Infectious Disease, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510; bHoward Hughes Medical Institute, Chevy Chase, MD 20815; cMicrobial Sciences Institute, Yale University, West Haven, CT 06516; dDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520; eLaboratory for Molecular Infection Medicine Sweden, Department of Molecular Biology, Umeå Center for Microbial Research, Umeå University, 901 87 Umea, Sweden; fRush Medical College, Rush University Medical Center, Chicago, IL 60612; gDepartment of Biology, Fairfield University, Fairfield, CT 06824; hDepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA 23298; and iDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06520 Edited by Joao Pedra, University of Maryland School of Medicine, Baltimore, MD, and accepted by Editorial Board Member Carolina Barillas-Mury December 8, 2016 (received for review August 17, 2016) Arthropods transmit diverse infectious agents; however, the ways granulocytic anaplasmosis, an illness that can result in fever, microbes influence their vector to enhance colonization are poorly headache, muscle pains, and pancytopenia. In the northeastern understood. Ixodes scapularis ticks harbor numerous human pathogens, United States, A. phagocytophilum is primarily maintained within including Anaplasma phagocytophilum, the agent of human granulo- I. scapularis and Peromyscus leucopus, the white-footed mouse cytic anaplasmosis.
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