M.Balakrishnan et al. / Journal of Pharmacy Research 2011,4(10),3702-3704 Research Article Available online through ISSN: 0974-6943 http://jprsolutions.info Design and Development of Aloe vera Chemical Constituent Systems (ACCS) M.Balakrishnan 1*, M.Ramachandran 2 and R.C.Srivastava3 1, 2 Bioinformatics Centre, Central Agricultural Research Institute, Port Blair-744101, Andaman & Nicobar Islands,India 3 Drirector, Central Agricultural Research Institute, Port Blair-744101, Andaman & Nicobar Islands,India Received on: 19-06-2011; Revised on: 08-07-2011; Accepted on:01-10-2011 ABSTRACT The Andaman and Nicobar Islands comprise chain of more than 350 major islands in addition to a number of islets and rock outcrops in the Bay of Bengal lying between latitudes 6° and 14° N and longitudes 92° and 94° E. Aloevera chemical constituent systems was developed by front end VB.net and back ends MS SQL. The valuable system to reveal the details regarding the routes of entire chemicals and enzymes properties. This system also gives information of the Aloe vera phytochemicals for the prevalent to complex diseases in Andaman and Nicobar Islands based on the research work carried out. This paper focuses on the details of Aloe vera chemical components as well as proteins, control of chronic diseases of plant and animals. Key words: Aloe vera, Phytochemical, MS SQL, VB.Net. INTRODUCTION Aloevera is a stem less or very short-stemmed succulent plant. Aloe vera ture is required (12). Aloevera leaves contain a range of biologically active leaves contain biologically active compounds Acetylated mannans, compounds, the best studied being acetylated mannans, polymannans, an- polymannans, Anthraquinons C-glycosides, Anthrones, Lectins Enzymes etc. thraquinone C-glycosides, anthrones and anthraquinones and various lectins Many of the health benefits associated with Aloevera have been attributed to (13,14,15). Scientific evidence for the cosmetic and therapeutic effectiveness the polysaccharides contained in the gel of the leaves. These biological activi- of Aloevera is limited and when present is frequently contradictory (16). It is ties include promotion of wound healing, antifungal activity, hypoglycemic or common practice for cosmetic companies to add sap or other derivatives from ant diabetic effects anti-inflammatory, anticancer, and immunomodulatory Aloevera to products such as makeup, tissues, moisturizers, soaps, sunscreens, and gastro protective properties(1). incense, razors and shampoos (17, 18). Other uses for extracts of Aloevera include the dilution of semen for the artificial fertilization of sheep, use as These effects include the potential of whole leaf or inner fillet gel liquid fresh food preservative, and use in water conservation in small farms. Aloevera preparations of A. vera to enhance the intestinal absorption and bioavailability extracts have antibacterial and antifungal activities, which may help in the of co-administered compounds as well as enhancement of skin permeation (2,3). In addition, important pharmaceutical applications such as the use of treatment of minor skin infections, such as boils and benign skin cysts(19,20). the dried A. vera gel powder as an excipient in sustained release pharmaceuti- Aloevera extracts have been shown to inhibit the growth of fungi that cause cal dosage forms will be outlined (4). Aloe vera is relatively closely related to tinea. Topical application of Aloevera may be effective for genital herpes and Aloe perryi, a species that is endemic to Yemen. Similar techniques, using psoriasis (21) . However, it is not effective for the prevention of radiation- chloroplast DNA sequence comparison and ISSR profiling have also suggested induced injuries. Aloevera is alleged to be effective in treatment of wounds. that Aloe vera is closely related to Aloe forbesii, Aloe inermis, Aloe scobinifolia, Aloevera promotes the rates of healing, while in contrast, other studies show Aloe sinkatana and Aloe striata. With the exception of South African species, that wounds to which Aloevera gel was applied were significantly slower to heal A. striata, these Aloe species are native to Socotra, Somalia and Sudan (5,6). than those treated with conventional medical preparations. The lacks of obvious natural populations of the species have led some authors to suggest that Aloe vera may be of hybrid origin. Aloe vera has been widely grown as an ornamental plant. The species is popular with modern gardeners as a putatively medicinal plant and due to its interesting flowers, form and succulence (7,8). This succulence enables the species to survive in areas of low natural rainfall, making it ideal for rockeries and other low-water use gardens. The species is hardy in zones 8–11, although it is intolerant of very heavy frost or snow (9,10). The species is relatively resistant to most insect pests, though spider mites, mealy bugs, scale insects and aphid species may cause a decline in plant health. In pots, the species requires well-drained sandy potting soil and bright sunny conditions; however, in very hot and humid tropical or subtropical climates, aloe plants should be protected from direct sun and rain, as they will burn and/or turn mushy easily under these conditions. The use of a good quality commercial propagation mix or pre-packaged “cacti and succu- lent mix” is recommended as they allow good drainage (11). Terracotta pots are preferable as they are porous. Potted plants should be allowed to com- pletely dry prior to re-watering. When potted aloes become crowded with “pups” growing from the sides of the “mother plant,” they should be divided and re-potted to allow room for further growth and help prevent pest infesta- tions. During winter, A. vera may become dormant, during which little mois- *Corresponding author. MATERIALS AND METHODS Dr. M. Balakrishnan Aloe vera chemical constituent systems were prepared using VB.net and MS SQL. VB.net is the advanced form VB6 and it gives the user a good working Coordinator, Bioinformatics Centre environment to know about the aloe chemical and proteins. The information Central Agricultural Research Institute system was developed by Bioinformatics Centre, Central Agricultural Research Port Blair 744101 Institute, Port Blair. The valuable system to reveal the details regarding the all Andaman & Nicobar Islands India aleovera phyto components. This system also gives information of the aloevera phytochemicals for the prevalent to complex diseases in Andaman and Nicobar Islands based on the research work carried out. Journal of Pharmacy Research Vol.4.Issue 10. October 2011 3702-3704 M.Balakrishnan et al. / Journal of Pharmacy Research 2011,4(10),3702-3704 such as plant name, scientific name, family, habitat, characteristics, distribu- tions, chemical properties were collected and documented. In addition to this, secondary data were also collected from institute / organization of these islands and mainland such as Botanical Survey of India (BSI), Department of Agriculture etc. Other information included various publications coming from these islands as well as mainland. Database Construction Visual Basic .NET This front end Software was used by VB.Net 2005. Visual Basic .NET is an object-oriented computer programming language that can be viewed as an evolution of Microsoft’s Visual Basic (VB) which is generally implemented on the Microsoft .NET Framework. Microsoft currently supplies Visual Basic Express Edition free of charge (24, 25, 26). Microsoft SQL Server All data of plant disease informations were entered and maintained by MS SQL 2005. Microsoft SQL Server is a relational model database server pro- Figure 1: Main Menu Page of Aloe vera chemical constituents systems duced by Microsoft. The main unit of data storage is a database, which is a collection of tables with typed columns. SQL Server supports different data types, including primary types such as Integer, Float, Decimal, Char, Varchar, binary and Text among others. In addition to tables, a database can also contain other objects including views, stored procedures, indexes and con- straints, along with a transaction log. Storage space was to a database and divided into sequentially numbered pages, each 8 KB in size. A page is the basic unit of I/O for SQL Server operations. A page is marked with a 96-byte header which stores metadata about the page including the page number, page type, free space on the page and the ID of the object that owns it. Page type defines the data contained in the page - data stored in the database, index, allocation map which holds information about how pages are allocated to tables and indexes, change map which holds information about the changes made to other pages since last backup or logging, or contain large data types such as image or text (22,23). Figure 2: Chemical components of Aloe vera page Figure 3: Execution page of Alo vera chemical constituents systems RESULTS AND DISCUSSION This System was developed under VB.net consists of a loading screen at the Data Collection beginning. When the user the Enter Button the loading bar starts running. An extensive survey was conducted in various places of Andaman and Nicobar After loading, the page takes you to the Home page which is built with a Menu group of Islands, to get primary and secondary datas about the Aloe vera bar with the menus file, search by chemical, taxonomy, etymology, practices, plants and photochemical components. The information was crosschecked chemicals and about us. The File menu consists of Open a file and Close the and authenticated. In this survey, all details regarding plants and chemicals file or exit the entire program. Journal of Pharmacy Research Vol.4.Issue 10. October 2011 3702-3704 M.Balakrishnan et al. / Journal of Pharmacy Research 2011,4(10),3702-3704 Under Search By chemical tab, user can select chemical properties like an- Fitoterapia 70, 1999, 395–401. throne, enzymes and organic compounds (Figure 2). Under Practices tab, one 10. Wang H, Li F, Wang T, Determination of aloin content in callus of Aloe vera var.