MEETING REPORT releasing Sir proteins from the be silenced by the Sir protein com- 3 Loo, S. and Rine, J. (1995) Annu. Ku70p–Ku80p telomerase complex plex. In summary, the importance of Rev. Cell Dev. Biol. 11, (David Shore, Univ. of Geneva, chromatin structure was evident in 519–548 Switzerland). Cdc13p protein binds all sessions. Yeast origins, cen- 4 Smith, J.S. and Boeke, J.D. (1997) single-stranded DNA at the tromeres and telomeres bind elegant Genes Dev. 11, 241–254 Ku70p–Ku80p telomerase complex multiprotein complexes that act as 5 Weaver, D.T. (1995) Trends Genet. (Vicki Lundblad, Baylor, USA). regulatory machines to change 11, 388–392 Nuclear organization of telomeres is chromatin structure and to allow important with telomeres located at important cellular processes to occur. the nuclear periphery (Sussan Robert A. Sclafani
[email protected] Gasser, ISREC, Switzerland). Target- Further reading ting DNA to the periphery using a 1 Dutta, A. and Bell, S.P. (1997) ER–Golgi anchoring signal can pro- Annu. Rev. Cell Dev. Biol. 13, Department of Biochemistry and Molecular duce silencing (Rolf Sternglanz, 293–332 Genetics, University of Colorado Health SUNY, USA). Hence, any gene 2 Pluta, A.F. et al. (1995) Science 270, Sciences Center, 4200 E. Ninth Avenue, brought to the nuclear periphery will 1591–1594 Denver, CO 80262, USA. LETTER reasoned that a detailed comparison Evidence for massive gene exchange of the Aquifex and archaeal between archaeal and bacterial genomes could reveal genome-scale adaptations for thermophily. hyperthermophiles The protein sequences encoded in all complete bacterial genomes were compared with the non- redundant protein sequence Sequencing of multiple complete exceptional among bacteria in that it database using the gapped BLAST genomes of bacteria and archaea occupies the hyperthermophilic program7, and a phylogenetic makes it possible to perform niche otherwise dominated by breakdown was automatically systematic, genome-scale archaea2.