IPC Classification
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Mitochondrial Ubiquitin Ligase MITOL Blocks S-Nitrosylated MAP1B-Light Chain 1-Mediated Mitochondrial Dysfunction and Neuronal Cell Death
Mitochondrial ubiquitin ligase MITOL blocks S-nitrosylated MAP1B-light chain 1-mediated mitochondrial dysfunction and neuronal cell death Ryo Yonashiro, Yuya Kimijima, Takuya Shimura, Kohei Kawaguchi, Toshifumi Fukuda, Ryoko Inatome, and Shigeru Yanagi1 Laboratory of Molecular Biochemistry, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan Edited by Ted M. Dawson, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, and accepted by the Editorial Board January 3, 2012 (received for review September 14, 2011) Nitric oxide (NO) is implicated in neuronal cell survival. However, recently been shown to be S-nitrosylated on cysteine 257 and excessive NO production mediates neuronal cell death, in part via translocated to microtubules via a conformational change of LC1 mitochondrial dysfunction. Here, we report that the mitochondrial (12). Additionally, LC1 has been implicated in human neuro- ubiquitin ligase, MITOL, protects neuronal cells from mitochondrial logical disorders, such as giant axonal neuropathy (GAN), frag- damage caused by accumulation of S-nitrosylated microtubule- ile-X syndrome, spinocerebellar ataxia type 1, and Parkinson associated protein 1B-light chain 1 (LC1). S-nitrosylation of LC1 in- disease (10, 13, 14). Therefore, the control of S-nitrosylated LC1 duces a conformational change that serves both to activate LC1 and levels is critical for neuronal cell survival. fi to promote its ubiquination by MITOL, indicating that microtubule We previously identi ed a mitochondrial ubiquitin ligase, MITOL (also known as March5), which is involved in mito- stabilization by LC1 is regulated through its interaction with MITOL. – Excessive NO production can inhibit MITOL, and MITOL inhibition chondrial dynamics and mitochondrial quality control (15 19). -
IPC Accessibility Guide
2 TABLE OF CONTENTS FIGURES AND TABLES ................................................................................................................. 8 Foreword ........................................................................................................................................... 10 Introduction ................................................................................................................................. 10 Evolving content ......................................................................................................................... 10 Disclosure ...................................................................................................................................... 11 Structure and content of the IPC Accessibility Guide ...................................................... 11 Content ........................................................................................................................................... 11 Executive summary ......................................................................................................................... 12 Aim and purpose of the Guide ................................................................................................ 12 Key objectives of the Guide ..................................................................................................... 12 Target audience of the Guide ................................................................................................. 12 1 General information -
ATTACHMENT 5 Lrgo-C960965-00-V
ATTACHMENT5 4. SHOCIqVIBRATION, AND ACOUSTICSANALYSIS 5. DESIGN GOALS/REQUIREMENTS vtHg-2-0!'5 REV. O SPECIfICATIONS TITLE DOCUMENTNO. REV. EquipmentSpecif cations Main RoughingPurnp Carts v049-2-001 Main TurbomolecularPump Cans v049-2-002 4 Auxiliary TurbomolecularPump Cans v049-2-003 Ion Pumps v049-2-004 2 ll2 and 122cm GateValves v049-2-005 J 10" and 14" GateValves v049-2-006 I VacuumGauges v049-2-007 0 BakeoutBlanlet System v049-2-009 I PortableSoft Wall CleanRooms vM9-2-010 0 CleanAir Supplies v049-2-011 I LN: Dewars v049-2-013 1 VacuumJack*ed Piping v049-2-016 PI BellowsExpansion Joints v049-2-017 I AmbientAir Vaporizers v049-2-055 0 80K PumpRegaroation Heater v049-2-056 0 SmallVacuum Valves v&9-2-059 0 CleanQh Tum Valves v049-2-050 0 CryogenicControl Valves v049-2-062 0 BakeoutCart v049-2-068 2 LrGO-C960965-00-v TITLE DOCUMENTNO. REV. Instrument& Control Specifications InstrumentList v049-l -036 0 E&lConstructionWork v049-2-022 0 PersonalComputers v049-2-049 0 BakeoutSystem Thermocouple v049-2-050 I MeasurementSystem T/C MeasurementPLC Interface v049-2-051 0 BakeoutPLC-TCInterface Soft ware v049-2-053 1 Functionality BakeoutSystem PC-PlC Interface v049-2-057 0 BakeoutSystem PC InterfaceSoftware v049-2-058 0 PitotTubes v049-2-079 0 DifferentialPressure Transmitlers v049-2-088 0 LevelTransmitters v049-2-089 0 PressureTransmitters v049-2-090 0 TemperatureElements v049-2-091 0 Interlocks,Permissives and Software AIarms v049-2-092 0 Material Specifications O-fungs v049-2-045 0 StainlessSteel Vessel Plate v049-2-041 1 StainlessSteel Flange Forgings v049-2-040 4 StainlessSteel Vessel Heads v049-2-039 3 LIGO VACUUM EQUIPMENT FINAL DESIGNREPORT CDRL 03 VOLUME TABLE OF CONTENT VOLUME TITLE VolumeI Project ManagementPlan VolumeII Design VolumeII AuachmentI Calculations VolumeII Attachment2 Calculations VolumeII Attachment3 Calculations Volumell Attachment4 Calculations VolumeII Attachment5 Specifications/Ir,lisc. -
Federal Hansard Acronyms List Remember: Ctrl+F for Quick Searches
Federal Hansard Acronyms List Remember: Ctrl+F for quick searches A B C D E F G H I J K L M N O P Q R S T U V W X Y Z A 2.5G [the first packet overlays on 2G networks] 2G second generation [the first generation of digital cellular networks, as opposed to analog] 3G third generation [next generation of cellular networks] 3GPP 3G Partnership Project [global standards body to oversee 3G] 4D meat from dead, dying, diseased or disabled animals 4GL fourth-generation language [computers] A&C automation and control A&D admission and disposition; alcohol and drugs A&E accident and emergency A&RMC formerly Austin & Repatriation Medical Centre [now Austin Health] AA anti-aircraft; Alcoholics Anonymous; Athletics Australia AAA Agriculture Advancing Australia; Australian Automobile Association; Australian Archaeological Association; Australian Airports Association AAAA Aerial Agricultural Association of Australia AAAE Australian Association of Automotive Electricians AAAGP Australian Association of Academic General Practice AAALAC Association for the Assessment and Accreditation of Laboratory Animal Care International AAB Australian Associated Brewers AAC Aboriginal advisory committee; Australian Arabic Council; AARNet Advisory Committee AACAP ATSIC-Army Community Assistance Program AACC Aboriginal Affairs Coordinating Committee [WA]; Australian Association of Career Counsellors AACM Australian Association for Computational Mechanics AACS Australian Associations of Christian Schools [note: Associations—plural] AACV Australian Association of Cattle Veterinarians AAD Australian Antarctic Division [Department of the Environment and Heritage] AADCP ASEAN-Australia Development Cooperation Program [taking over AAECP] AADS advanced air defence simulator AADT average annual daily traffic AaE Australian air Express Pty Ltd AAEC Antarctic Animal Ethics Committee AAECP ASEAN-Australia Economic Cooperation Program [finishes in 2005] AAFCANS Army and Air Force Canteen Service [now known as Frontline Defence Services] AAGP Australian Association of Group Psychotherapists Inc. -
Latent Class Analysis to Classify Patients with Transthyretin Amyloidosis by Signs and Symptoms
Neurol Ther DOI 10.1007/s40120-015-0028-y ORIGINAL RESEARCH Latent Class Analysis to Classify Patients with Transthyretin Amyloidosis by Signs and Symptoms Jose Alvir . Michelle Stewart . Isabel Conceic¸a˜o To view enhanced content go to www.neurologytherapy-open.com Received: February 21, 2015 Ó The Author(s) 2015. This article is published with open access at Springerlink.com ABSTRACT status measures for the latent classes were examined. Introduction: The aim of this study was to Results: A four-class latent class solution was develop an empirical approach to classifying thebestfitforthedata.Thelatentclasseswere patients with transthyretin amyloidosis (ATTR) characterized by the predominant symptoms based on clinical signs and symptoms. as severe neuropathy/severe autonomic, Methods: Data from 971 symptomatic subjects moderate to severe neuropathy/low to enrolled in the Transthyretin Amyloidosis moderate autonomic involvement, severe Outcomes Survey were analyzed using a latent cardiac, and moderate to severe neuropathy. class analysis approach. Differences in health Incorporating disease duration improved the model fit. It was found that measures of health Electronic supplementary material The online status varied by latent class in interpretable version of this article (doi:10.1007/s40120-015-0028-y) contains supplementary material, which is available to patterns. authorized users. Conclusion: This latent class analysis approach On behalf of the THAOS Investigators. offered promise in categorizing patients with ATTR across the spectrum of disease. The four- Trial registration: ClinicalTrials.gov number, class latent class solution included disease NCT00628745. duration and enabled better detection of J. Alvir (&) heterogeneity within and across genotypes Statistical Center for Outcomes, Real-World and than previous approaches, which have tended Aggregate Data, Global Medicines Development, Global Innovative Pharma Business, Pfizer, Inc., to classify patients a priori into neuropathic, New York, NY, USA cardiac, and mixed groups. -
The HHS-HCC Risk Adjustment Model for Individual and Small Group Markets Under the Affordable Care Act John Kautter,1 Gregory C
2014: Volume 4, Number 3 A publication of the Centers for Medicare & Medicaid Services, Office of Information Products & Data Analytics The HHS-HCC Risk Adjustment Model for Individual and Small Group Markets under the Affordable Care Act John Kautter,1 Gregory C. Pope,1 Melvin Ingber,1 Sara Freeman,1 Lindsey Patterson,1 Michael Cohen,2 and Patricia Keenan2 1RTI International 2Centers for Medicare & Medicaid Services Abstract: Beginning in 2014, individuals and HHS-HCC diagnostic classification, which is the small businesses are able to purchase private health key element of the risk adjustment model. Then insurance through competitive Marketplaces. The the data and methods, results, and evaluation of Affordable Care Act (ACA) provides for a program the risk adjustment model are presented. Fifteen of risk adjustment in the individual and small group separate models are developed. For each age group markets in 2014 as Marketplaces are implemented (adult, child, and infant), a model is developed for and new market reforms take effect. The purpose each cost sharing level (platinum, gold, silver, and of risk adjustment is to lessen or eliminate the bronze metal levels, as well as catastrophic plans). influence of risk selection on the premiums that Evaluation of the risk adjustment models shows plans charge. The risk adjustment methodology good predictive accuracy, both for individuals and includes the risk adjustment model and the risk for groups. Lastly, this article provides examples transfer formula. of how the model output is used to calculate risk This article is the second of three in this scores, which are an input into the risk transfer issue of the Review that describe the Department formula. -
Annona Coriacea Mart. Fractions Promote Cell Cycle Arrest and Inhibit Autophagic Flux in Human Cervical Cancer Cell Lines
molecules Article Annona coriacea Mart. Fractions Promote Cell Cycle Arrest and Inhibit Autophagic Flux in Human Cervical Cancer Cell Lines Izabela N. Faria Gomes 1,2, Renato J. Silva-Oliveira 2 , Viviane A. Oliveira Silva 2 , Marcela N. Rosa 2, Patrik S. Vital 1 , Maria Cristina S. Barbosa 3,Fábio Vieira dos Santos 3 , João Gabriel M. Junqueira 4, Vanessa G. P. Severino 4 , Bruno G Oliveira 5, Wanderson Romão 5, Rui Manuel Reis 2,6,7,* and Rosy Iara Maciel de Azambuja Ribeiro 1,* 1 Experimental Pathology Laboratory, Federal University of São João del Rei—CCO/UFSJ, Divinópolis 35501-296, Brazil; [email protected] (I.N.F.G.); [email protected] (P.S.V.) 2 Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, Brazil; [email protected] (R.J.S.-O.); [email protected] (V.A.O.S.); [email protected] (M.N.R.) 3 Laboratory of Cell Biology and Mutagenesis, Federal University of São João del Rei—CCO/UFSJ, Divinópolis 35501-296, Brazil; [email protected] (M.C.S.B.); [email protected] (F.V.d.S.) 4 Special Academic Unit of Physics and Chemistry, Federal University of Goiás, Catalão 75704-020, Brazil; [email protected] (J.G.M.J.); [email protected] (V.G.P.S.) 5 Petroleomic and forensic chemistry laboratory, Department of Chemistry, Federal Institute of Espirito Santo, Vitória, ES 29075-910, Brazil; [email protected] (B.G.O.); [email protected] (W.R.) 6 Life and Health Sciences Research Institute (ICVS), Medical School, University of Minho, 4710-057 Braga, Portugal 7 3ICVS/3B’s-PT Government Associate Laboratory, 4710-057 Braga, Portugal * Correspondence: [email protected] (R.M.R.); [email protected] (R.I.M.d.A.R.); Tel.: +55-173-321-6600 (R.M.R.); +55-3736-904-484 or +55-3799-1619-155 (R.I.M.d.A.R.) Received: 25 September 2019; Accepted: 29 October 2019; Published: 1 November 2019 Abstract: Plant-based compounds are an option to explore and perhaps overcome the limitations of current antitumor treatments. -
DNV Classification Note 31.2 Strength Analysis of Hull Structure in Roll
CLASSIFICATION NOTES No. 31.2 STRENGTH ANALYSIS OF HULL STRUCTURE IN ROLL ON/ROLL OFF SHIPS AND CAR CARRIERS APRIL 2011 The content of this service document is the subject of intellectual property rights reserved by Det Norske Veritas AS (DNV). The user accepts that it is prohibited by anyone else but DNV and/or its licensees to offer and/or perform classification, certification and/or verification services, including the issuance of certificates and/or declarations of conformity, wholly or partly, on the basis of and/or pursuant to this document whether free of charge or chargeable, without DNV's prior written consent. DNV is not responsible for the consequences arising from any use of this document by others. DET NORSKE VERITAS Veritasveien 1, NO-1322 Høvik, Norway Tel.: +47 67 57 99 00 Fax: +47 67 57 99 11 FOREWORD DET NORSKE VERITAS (DNV) is an autonomous and independent foundation with the objectives of safeguarding life, property and the environment, at sea and onshore. DNV undertakes classification, certification, and other verification and consultancy services relating to quality of ships, offshore units and installations, and onshore industries worldwide, and carries out research in relation to these functions. Classification Notes Classification Notes are publications that give practical information on classification of ships and other objects. Examples of design solutions, calculation methods, specifications of test procedures, as well as acceptable repair methods for some components are given as interpretations of the more general rule requirements. All publications may be downloaded from the Society’s Web site http://www.dnv.com/. The Society reserves the exclusive right to interpret, decide equivalence or make exemptions to this Classification Note. -
Federal Register/Vol. 65, No. 69/Monday, April 10, 2000
19188 Federal Register / Vol. 65, No. 69 / Monday, April 10, 2000 / Proposed Rules DEPARTMENT OF HEALTH AND timely will be available for public 3. Payment ProvisionsÐFacility-Specific HUMAN SERVICES inspection as they are received, Rate generally beginning approximately 3 II. Update of Payment Rates Under the Health Care Financing Administration weeks after publication of a document, Prospective Payment System for Skilled Nursing Facilities in Room 443±G of the Department's A. Federal Prospective Payment System 42 CFR Parts 411 and 489 office at 200 Independence Avenue, 1. Cost and Services covered by the Federal SW., Washington, DC, on Monday [HCFA±1112±P] Rates through Friday of each week from 8:30 2. Methodology Used for the Calculation of RIN 0938±AJ93 to 5 p.m. (phone: (202) 690±7061). the Federal Rates FOR FURTHER INFORMATION CONTACT: B. Case-Mix Adjustment and Options C. Wage Index Adjustment to Federal Rates Medicare Program; Prospective Dana Burley, (410) 786±4547 or Sheila Payment System and Consolidated D. Updates to the Federal Rates Lambowitz, (410) 786±7605 (for E. Relationship of RUG±III Classification Billing for Skilled Nursing FacilitiesÐ information related to the case-mix Update System to Existing Skilled Nursing classification methodology). Facility Level-of-Care Criteria AGENCY: Health Care Financing John Davis, (410) 786±0008 (for III. Three-Year Transition Period Administration (HCFA), HHS. information related to the Wage IV. The Skilled Nursing Facility Market Index). Basket Index ACTION: Notice of proposed rulemaking. Bill Ullman, (410) 786±5667 (for A. Facility-Specific Rate Update Factor information related to consolidated B. Federal Rate Update Factor SUMMARY: This proposed rule sets forth V. -
Building the Paralympic Movement in Korea
THE Official Magazine of the International Paralympic Committee PARALYMPIAN ISSUE 4 2006 Japan in action on the road at the 2006 IPC Cycling World Championships. Photo ©: Prezioso CYCLING STANDARDS THE HIGHEST EVER The 2006 IPC Cycling World Championships In the women's Handcycling Division B-C Road provided six days of top-level international Race, Monique Van de Vorst (NED) crossed the line INSIDE competition from 10 to 18 September. The only milliseconds ahead of second placed Andrea Championships were organized by the International Eskau (GER). In the men's Handcycling Division B Cycling Union (UCI) and held in the World Cycling Road Race, the first four cyclists to cross the finish Centre at UCI Headquarters in Aigle, Switzerland. BOCOG Launches line arrived within a second of each other. The This provided the organizers and athletes with men's Road Races in the LC1, LC2 and LC3 sport New Mascot: Lele access to the best Cycling knowledge and facilities classes were all strongly contested as first, second p.2 and gave the world's top cyclists with a disability and third place also came down to less than a an opportunity to hit the track and the road for a second, showing the elite nature of the sport. shot at the World Champion titles. Online Education Said Tony Yorke, Chairperson of the IPC Cycling Programme for Germany came in first overall on the medal tally, Sport Technical Committee: "The rising standards London 2012 p.3 winning a total of 26 medals, including 12 gold. were clearly visible in all areas, including athlete They were followed by Spain with 21 medals, eight performances and the organization. -
Flow and Pressure Measurement Using Phase-Contrast MRI : Experiments in Stenotic Phantom Models
University of Louisville ThinkIR: The University of Louisville's Institutional Repository Electronic Theses and Dissertations 8-2012 Flow and pressure measurement using phase-contrast MRI : experiments in stenotic phantom models. Iman Khodarahmi University of Louisville Follow this and additional works at: https://ir.library.louisville.edu/etd Recommended Citation Khodarahmi, Iman, "Flow and pressure measurement using phase-contrast MRI : experiments in stenotic phantom models." (2012). Electronic Theses and Dissertations. Paper 744. https://doi.org/10.18297/etd/744 This Doctoral Dissertation is brought to you for free and open access by ThinkIR: The University of Louisville's Institutional Repository. It has been accepted for inclusion in Electronic Theses and Dissertations by an authorized administrator of ThinkIR: The University of Louisville's Institutional Repository. This title appears here courtesy of the author, who has retained all other copyrights. For more information, please contact [email protected]. FLOWAND PRESSURE MEASUREMENT USING PHASE-CONTRAST MRI: EXPERIMENTS IN STENOTIC PHANTOM MODELS By Iman Khodarahmi B.S., University of Tehran, 2006 M.S., University of Tehran, 2007 M.D., University of Tehran, 2007 A Dissertation Submitted to the Faculty of the J. B. Speed School of Engineering of the University of Louisville in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Department of Electrical and Computer Engineering University of Louisville Louisville, Kentucky August 2012 Copyright 2012 by Iman Khodarahmi All rights reserved FLOW AND PRESSURE MEASUREMENT USING PHASE-CONTRAST MRI: EXPERIMENTS IN PHANTOM MODELS By Iman Khodarahmi Qahnavieh B.S., University of Tehran, 2006 M.S., University of Tehran, 2007 M.D., University of Tehran, 2007 A Dissertation Approved on May 29,2012 By the following Dissertation Committee Dr. -
United States Olympic Committee and U.S. Department of Veterans Affairs
SELECTION STANDARDS United States Olympic Committee and U.S. Department of Veterans Affairs Veteran Monthly Assistance Allowance Program The U.S. Olympic Committee supports Paralympic-eligible military veterans in their efforts to represent the USA at the Paralympic Games and other international sport competitions. Veterans who demonstrate exceptional sport skills and the commitment necessary to pursue elite-level competition are given guidance on securing the training, support, and coaching needed to qualify for Team USA and achieve their Paralympic dreams. Through a partnership between the United States Department of Veterans Affairs and the USOC, the VA National Veterans Sports Programs & Special Events Office provides a monthly assistance allowance for disabled Veterans of the Armed Forces training in a Paralympic sport, as authorized by 38 U.S.C. § 322(d) and section 703 of the Veterans’ Benefits Improvement Act of 2008. Through the program the VA will pay a monthly allowance to a Veteran with a service-connected or non-service-connected disability if the Veteran meets the minimum VA Monthly Assistance Allowance (VMAA) Standard in his/her respective sport and sport class at a recognized competition. Athletes must have established training and competition plans and are responsible for turning in monthly and/or quarterly forms and reports in order to continue receiving the monthly assistance allowance. Additionally, an athlete must be U.S. citizen OR permanent resident to be eligible. Lastly, in order to be eligible for the VMAA athletes must undergo either national or international classification evaluation (and be found Paralympic sport eligible) within six months of being placed on the allowance pay list.