Meyricke Library Classification a Mathematics B Physics C Chemistry
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Mitochondrial Ubiquitin Ligase MITOL Blocks S-Nitrosylated MAP1B-Light Chain 1-Mediated Mitochondrial Dysfunction and Neuronal Cell Death
Mitochondrial ubiquitin ligase MITOL blocks S-nitrosylated MAP1B-light chain 1-mediated mitochondrial dysfunction and neuronal cell death Ryo Yonashiro, Yuya Kimijima, Takuya Shimura, Kohei Kawaguchi, Toshifumi Fukuda, Ryoko Inatome, and Shigeru Yanagi1 Laboratory of Molecular Biochemistry, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan Edited by Ted M. Dawson, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, and accepted by the Editorial Board January 3, 2012 (received for review September 14, 2011) Nitric oxide (NO) is implicated in neuronal cell survival. However, recently been shown to be S-nitrosylated on cysteine 257 and excessive NO production mediates neuronal cell death, in part via translocated to microtubules via a conformational change of LC1 mitochondrial dysfunction. Here, we report that the mitochondrial (12). Additionally, LC1 has been implicated in human neuro- ubiquitin ligase, MITOL, protects neuronal cells from mitochondrial logical disorders, such as giant axonal neuropathy (GAN), frag- damage caused by accumulation of S-nitrosylated microtubule- ile-X syndrome, spinocerebellar ataxia type 1, and Parkinson associated protein 1B-light chain 1 (LC1). S-nitrosylation of LC1 in- disease (10, 13, 14). Therefore, the control of S-nitrosylated LC1 duces a conformational change that serves both to activate LC1 and levels is critical for neuronal cell survival. fi to promote its ubiquination by MITOL, indicating that microtubule We previously identi ed a mitochondrial ubiquitin ligase, MITOL (also known as March5), which is involved in mito- stabilization by LC1 is regulated through its interaction with MITOL. – Excessive NO production can inhibit MITOL, and MITOL inhibition chondrial dynamics and mitochondrial quality control (15 19). -
Before the Public Service Commission of the State of Missouri
Exhibit No.: Issues: Depreciation Witness: Brian C. Andrews Type of Exhibit: Direct Testimony Sponsoring Party: Missouri Industrial Energy Consumers Case No.: ER-2019-0335 Date Testimony Prepared: December 4, 2019 FILED March 19, 2020 Data Center BEFORE THE PUBLIC SERVICE COMMISSION Missouri Public OF THE STATE OF MISSOURI Service Commission ) In the Matter of Union Electric Company ) d/b/a Ameren Missouri's Tariffs to Decrease ) Case No. ER-2019-0335 Its Revenues for Electric Service. ) ------------) Direct Testimony and Schedules of Brian C. Andrews On behalf of Missouri Industrial Energy Consumers December 4, 2019 BRUIIAKr R & ASSOCIATES. INC. Project 10842 BEFORE THE PUBLIC SERVICE COMMISSION OF THE STATE OF MISSOURI ) In the Matter of Union Electric Company ) d/b/a Ameren Missouri's Tariffs to Decrease ) Case No. ER-2019-0335 Its Revenues for Electric Service. ) ) STATE OF MISSOURI ) ) ss COUNTY OF ST. LOUIS ) Affidavit of Brian C. Andrews Brian C. Andrews, being first duly sworn, on his oath states: 1. My name is Brian C. Andrews. I am a consultant with Brubaker & Associates, Inc., having its principal place of business at 16690 Swingley Ridge Road, Suite 140, Chesterfield, Missouri 63017. We have been retained by the Missouri Industrial Energy Consumers in this proceeding on their behalf. 2. Attached hereto and made a part hereof for all purposes are my direct testimony and schedules which were prepared in written form for introduction into evidence in Missouri Public Service Commission Case No. ER-2019-0335. 3. I hereby swear and affirm that the testimony and schedules are true and correct and that they show the matters and things that they purport to show. -
Get Instruction Manual
We strive to ensure that our produc ts are of the highest quality and free of manufacturing defec ts or missing par ts. Howeve r, if you have any problems with your new product, please contact us toll free at: 1-88 8 - 577 - 4460 [email protected] Or w r it e t o: Victory Tailgate Customer Service Departmen t 2437 E Landstreet Rd Orlando,FL 32824 www.victorytailgate.com Please have your model number when inquiring about parts. When con t ac ting Escalade S por t s please provide your model numbe r , date code (i f applicable ), and pa rt nu mbe r i f reque sting a repla c emen t pa rt. The s e nu mbe rs a re loc ated on the p rodu ct, pa ckaging , and in thi s owne rs manual . Your Model Number : M01530W Date Code: 2-M01530W- -JL Purchase Date: PLEASE RETAIN THIS INSTRUCTION MANUAL FOR FUTURE REFERENCE All Rights Reserved © 2019 Escalade Spor ts 1 For Customer Service Call 1-888-577-4460 IMPORTANT! READ EACH STEP IN THIS MANUAL BEFORE YOU BEGIN THE ASSEMBLY. TWO (2) ADU LTS ARE REQUIRED TO ASSEMBLE THISDOUBLE SHOOTOUT Tools Needed: Allen Wrench (provided)Phillips Screwdriver Plyers ! Make sure you understand the following tips before you begin to assemble your basketball shootout. 1.This game (with Mechanical Scoring Arm) can be played outdoors in dry weather - but must be stored indoors. 2.Tighten hardware as instructed. 3.Do not over tighten hardware,as you could crush the tubing. 4.Some drawings or images in this manual may not look exactly like your product. -
Paralympic Team Belgium Guide.Pdf
PARALYMPIC TEAM BELGIUM GUIDE POWERED BY RIO / 7-18 SEPT FOLLOW OUR ATHLETES AT PARALYMPIC.BE BEPARALYMPICS Rio de Janeiro TABLE OF CONTENTS 4 Foreword President and Secretary General BPC 5 Foreword Chef de Mission 6 Map Rio 8 About Rio 2016 9 Paralympic Team Belgium 10 Athletics 14 Boccia 18 Cycling 24 Para-equestrian 28 Swimming 32 Table tennis 36 Wheelchair Tennis 41 Belgium and the Paralympic Summer Games 42 Our Team 43 Our partners Realisation BPC Avenue de Boechoutlaan 9 – 1020 Bruxelles/Brussel Responsible Publisher Anne d’Ieteren – President BPC Editing Antoine Collard (BPC), Guillaume Gobert (BPC), Jeroen Bauters (Parantee), Thomas Degryse (LHF) Pictures Luc Dequick, Olivier Papegnies, Frank Van Hollebeke, BPC, ROCOG, Marcus Hartmann, Tennis Foundation Graphic Design FootballHeroes 2 © ROCOG 3 foreword foreword ore than 4000 athletes from all ooking ahead to the upcoming over the world will converge in Rio 2016 Paralympic Games, the M Rio de Janeiro from September L excitement of these Games is 7 until September 18, for the 15th edition growing in the hearts of our athletes as of the Paralympic Summer Games. After their minds remain focused on their final the tremendous success of London preparations. The feeling of living for Rio 2012, these first South American Games 2016, of Rio giving them the necessary will be the measure of how far the energy to overcome their daily Paralympic Movement has come these challenges, is the feeling that has driven past years. our team towards these Games. As this guide will illustrate, Belgium can be Of course, we all realize the efforts and proud of the direction that has been taken sacrifices our athletes had to make Anne d’Ieteren by its national Paralympic competitors. -
ELIGIBILITY Para-Cycling Athletes: Must Be a United States Citizen With
ELIGIBILITY Para-cycling Athletes: Must be a United States citizen with a USA racing nationality. LICENSING National Championships: Riders may have a current International or Domestic USA Cycling license (USA citizenship) or Foreign Federation license showing a USA racing nationality to register. World Championships Selection: Riders must have a current International USA Cycling license with a USA racing nationality on or before June 20, 2019 in order to be selected for the Team USA roster for the 2019 UCI Para-cycling Road World Championships. Selection procedures for the World Championships can be found on the U.S. Paralympics Cycling Website: https://www.teamusa.org/US- Paralympics/Sports/Cycling/Selection-Procedures REGULATIONS General: All events conducted under UCI Regulations, including UCI equipment regulations. Road Race and Time Trials: • No National Team Kit or National championship uniforms are allowed. • For the Road Race, only neutral service and official’s cars are allowed in the caravan. • For the Time Trial, bicycles and handcycles must be checked 15 minutes before the athlete’s assigned start time. Courtesy checks will be available from 1 hour before the first start. No follow vehicles are allowed. • For all sport classes in the road race, athletes are required to wear a helmet in the correct sport class color, or use an appropriately color helmet cover, as follows: RED MC5, WC5, MT2, MH4, WH4, MB WHITE MC4, WC4, MH3, WH3, WB, WT2 BLUE MC3, WC3, MH2, WT1 BLACK MH5, WH5, MC2, WC2, MT1 YELLOW MC1, WC1, WH2 GREEN MH1 ORANGE WH1 Handcycle Team Relay (TR): New National Championship event run under UCI and special regulations below: • Team Requirements: Teams eligible for the National Championship Team Relay, must be respect the following composition: o Teams of three athletes o Using the table below, the total of points for the three TR athletes may not be more than six (6) points which must include an athlete with a scoring point value of 1. -
Building the Paralympic Movement in Korea
THE Official Magazine of the International Paralympic Committee PARALYMPIAN ISSUE 4 2006 Japan in action on the road at the 2006 IPC Cycling World Championships. Photo ©: Prezioso CYCLING STANDARDS THE HIGHEST EVER The 2006 IPC Cycling World Championships In the women's Handcycling Division B-C Road provided six days of top-level international Race, Monique Van de Vorst (NED) crossed the line INSIDE competition from 10 to 18 September. The only milliseconds ahead of second placed Andrea Championships were organized by the International Eskau (GER). In the men's Handcycling Division B Cycling Union (UCI) and held in the World Cycling Road Race, the first four cyclists to cross the finish Centre at UCI Headquarters in Aigle, Switzerland. BOCOG Launches line arrived within a second of each other. The This provided the organizers and athletes with men's Road Races in the LC1, LC2 and LC3 sport New Mascot: Lele access to the best Cycling knowledge and facilities classes were all strongly contested as first, second p.2 and gave the world's top cyclists with a disability and third place also came down to less than a an opportunity to hit the track and the road for a second, showing the elite nature of the sport. shot at the World Champion titles. Online Education Said Tony Yorke, Chairperson of the IPC Cycling Programme for Germany came in first overall on the medal tally, Sport Technical Committee: "The rising standards London 2012 p.3 winning a total of 26 medals, including 12 gold. were clearly visible in all areas, including athlete They were followed by Spain with 21 medals, eight performances and the organization. -
Flow and Pressure Measurement Using Phase-Contrast MRI : Experiments in Stenotic Phantom Models
University of Louisville ThinkIR: The University of Louisville's Institutional Repository Electronic Theses and Dissertations 8-2012 Flow and pressure measurement using phase-contrast MRI : experiments in stenotic phantom models. Iman Khodarahmi University of Louisville Follow this and additional works at: https://ir.library.louisville.edu/etd Recommended Citation Khodarahmi, Iman, "Flow and pressure measurement using phase-contrast MRI : experiments in stenotic phantom models." (2012). Electronic Theses and Dissertations. Paper 744. https://doi.org/10.18297/etd/744 This Doctoral Dissertation is brought to you for free and open access by ThinkIR: The University of Louisville's Institutional Repository. It has been accepted for inclusion in Electronic Theses and Dissertations by an authorized administrator of ThinkIR: The University of Louisville's Institutional Repository. This title appears here courtesy of the author, who has retained all other copyrights. For more information, please contact [email protected]. FLOWAND PRESSURE MEASUREMENT USING PHASE-CONTRAST MRI: EXPERIMENTS IN STENOTIC PHANTOM MODELS By Iman Khodarahmi B.S., University of Tehran, 2006 M.S., University of Tehran, 2007 M.D., University of Tehran, 2007 A Dissertation Submitted to the Faculty of the J. B. Speed School of Engineering of the University of Louisville in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Department of Electrical and Computer Engineering University of Louisville Louisville, Kentucky August 2012 Copyright 2012 by Iman Khodarahmi All rights reserved FLOW AND PRESSURE MEASUREMENT USING PHASE-CONTRAST MRI: EXPERIMENTS IN PHANTOM MODELS By Iman Khodarahmi Qahnavieh B.S., University of Tehran, 2006 M.S., University of Tehran, 2007 M.D., University of Tehran, 2007 A Dissertation Approved on May 29,2012 By the following Dissertation Committee Dr. -
United States Olympic Committee and U.S. Department of Veterans Affairs
SELECTION STANDARDS United States Olympic Committee and U.S. Department of Veterans Affairs Veteran Monthly Assistance Allowance Program The U.S. Olympic Committee supports Paralympic-eligible military veterans in their efforts to represent the USA at the Paralympic Games and other international sport competitions. Veterans who demonstrate exceptional sport skills and the commitment necessary to pursue elite-level competition are given guidance on securing the training, support, and coaching needed to qualify for Team USA and achieve their Paralympic dreams. Through a partnership between the United States Department of Veterans Affairs and the USOC, the VA National Veterans Sports Programs & Special Events Office provides a monthly assistance allowance for disabled Veterans of the Armed Forces training in a Paralympic sport, as authorized by 38 U.S.C. § 322(d) and section 703 of the Veterans’ Benefits Improvement Act of 2008. Through the program the VA will pay a monthly allowance to a Veteran with a service-connected or non-service-connected disability if the Veteran meets the minimum VA Monthly Assistance Allowance (VMAA) Standard in his/her respective sport and sport class at a recognized competition. Athletes must have established training and competition plans and are responsible for turning in monthly and/or quarterly forms and reports in order to continue receiving the monthly assistance allowance. Additionally, an athlete must be U.S. citizen OR permanent resident to be eligible. Lastly, in order to be eligible for the VMAA athletes must undergo either national or international classification evaluation (and be found Paralympic sport eligible) within six months of being placed on the allowance pay list. -
The Intentions of International Tourists to Attend the 2016 Rio Summer Olympic and Paralympic Games: a Study of the Image of Rio De Janeiro and Brazil
Ann Appl Sport Sci 8(3): e798, 2020. http://www.aassjournal.com; e-ISSN: 2322–4479; p-ISSN: 2476–4981. 10.29252/aassjournal.798 ORIGINAL ARTICLE The Intentions of International Tourists to Attend the 2016 Rio Summer Olympic and Paralympic Games: A Study of the Image of Rio de Janeiro and Brazil Leonardo Jose Mataruna-Dos-Santos* College of Business Administration, American University in the Emirates, Dubai, UAE. Submitted 22 September 2019; Accepted in final form 27 February 2020. ABSTRACT Background. This paper investigates how hosting a mega sports event such as the 2016 Rio Games – Olympic and Paralympic influence the Rio de Janeiro and Brazil image’ like popular destinations among tourists. Objectives. The following hypotheses guided our research to identify the more positive image of Brazil as a tourism destination. Methods. A mixed research design combining both qualitative and quantitative approaches was used. Participants were recruited at the Technische Universität München and in the city center of Munich, Germany. The two dimensions (cognitive and affective) of the tourism destination image were considered to elaborate a questionnaire survey, which mixes both qualitative and quantitative methods. Results. The significant factors influencing the intentions of a person to attend the Games in Brazil are the positive portrayed image of the country and their sport interest. According to the multiple regression conducted, the only variables, which have influenced people’s intention to go to Brazil for the Olympics, were the image of the country as a tourism destination (β = 0.404, p < 0.05) and sports interests (β = 0.259, p < 0.05). -
Integrative Genomic Characterization Identifies Molecular Subtypes of Lung Carcinoids
Published OnlineFirst July 12, 2019; DOI: 10.1158/0008-5472.CAN-19-0214 Cancer Genome and Epigenome Research Integrative Genomic Characterization Identifies Molecular Subtypes of Lung Carcinoids Saurabh V. Laddha1, Edaise M. da Silva2, Kenneth Robzyk2, Brian R. Untch3, Hua Ke1, Natasha Rekhtman2, John T. Poirier4, William D. Travis2, Laura H. Tang2, and Chang S. Chan1,5 Abstract Lung carcinoids (LC) are rare and slow growing primary predominately found at peripheral and endobronchial lung, lung neuroendocrine tumors. We performed targeted exome respectively. The LC3 subtype was diagnosed at a younger age sequencing, mRNA sequencing, and DNA methylation array than LC1 and LC2 subtypes. IHC staining of two biomarkers, analysis on macro-dissected LCs. Recurrent mutations were ASCL1 and S100, sufficiently stratified the three subtypes. enriched for genes involved in covalent histone modification/ This molecular classification of LCs into three subtypes may chromatin remodeling (34.5%; MEN1, ARID1A, KMT2C, and facilitate understanding of their molecular mechanisms and KMT2A) as well as DNA repair (17.2%) pathways. Unsuper- improve diagnosis and clinical management. vised clustering and principle component analysis on gene expression and DNA methylation profiles showed three robust Significance: Integrative genomic analysis of lung carcinoids molecular subtypes (LC1, LC2, LC3) with distinct clinical identifies three novel molecular subtypes with distinct clinical features. MEN1 gene mutations were found to be exclusively features and provides insight into their distinctive molecular enriched in the LC2 subtype. LC1 and LC3 subtypes were signatures of tumorigenesis, diagnosis, and prognosis. Introduction of Ki67 between ACs and TCs does not enable reliable stratification between well-differentiated LCs (6, 7). -
Para Cycling Information Sheet About the Sport Classification Explained
Para cycling information sheet About the sport Para cycling is cycling for people with impairments resulting from a health condition (disability). Para athletes with physical impairments either compete on handcycles, tricycles or bicycles, while those with a visual impairment compete on tandems with a sighted ‘pilot’. Para cycling is divided into track and road events, with seven events in total. Classification explained In Para sport classification provides the structure for fair and equitable competition to ensure that winning is determined by skill, fitness, power, endurance, tactical ability and mental focus – the same factors that account for success in sport for able-bodied athletes. The Para sport classification assessment process identifies the eligibility of each Para athlete’s impairment, and groups them into a sport class according to the degree of activity limitation resulting from their impairment. Classification is sport-specific as an eligible impairment affects a Para athlete’s ability to perform in different sports to a different extent. Each Para sport has a different classification system. Standard Classification in detail Para-Cycling sport classes include: Handcycle sport classes H1 – 5: There are five different sport classes for handcycle racing. The lower numbers indicate a more severe activity limitation. Para athletes competing in the H1 classes have a complete loss of trunk and leg function and limited arm function, e.g. as a result of a spinal cord injury. Para athletes in the H4 class have limited or no leg function, but good trunk and arm function. Para cyclists in sport classes H1 – 4 compete in a reclined position. Para cyclists in the H5 sport class sit on their knees because they are able to use their arms and trunk to accelerate the handcycle. -
Labelling Systems ACS PRODUCT APPROVALS INSTALLATION METHOD
Labelling systems ACS PRODUCT APPROVALS INSTALLATION METHOD Rail vehicles Sleeve system Product approvals for rail vehicles from Mount by sliding sleeve over product Siemens, Bombardier, Alstom, Talgo for local and long-distance travel and for regional travel systems. Direct labelling system Direct push-on mounting system Cable tie system with sleeves Automotive industry Mounting the sleeve with cable ties Product approvals for plants and machinery in the auto industry including at Audi, BMW, Cable tie system label Citroën Peugeot, Daimler AG, Fiat, Karmann, Mounting the labels with cable ties Opel, Renault, VW Clamping system Mounting the sleeve with a clamping base Public buildings and institutions Self-clamping system Product approvals for media conducting Self-clamping base used to mount holder systems (electricity, air, water), supply, control, networks/grids, warning and sig- Adhesive system nalling units Label glued into place Snap-fit system Air, water, road transport Label snapped into place Product approvals for Aircraft: media-conducting systems, electric, Strip system hydraulic Strip snapped into place Water craft: Electro, hydraulic, pneumatic Street vehicles: Bus, lorry, special vehicles Riveting system Label riveted into place Screw assembly system Mechanical engineering Mounting the label with screws SPECIFICATIONS LABELLING TECHNOLOGY Temperature range Marking with plotter Material Marking with hand pen Fire classification UL 94 Marking with Office laser printer Additional information Marking via engraving Adhesive Marking