RECENT ADVANCE~3 IN DIURETIC THERAPY

Proceedings of the Second · International Edrul® Symposium

Sorrento, ltaly, 4-6 November 1B82

Editor: V.E. Andreucci

~ 1983 \3Y Excerpta Medica Contents

Welcome K. Deck Opening address G. Salvatore 2 Introduction V.E. Andreucci 3

SESSION I: SPECIAL LECTURE

Diuretic-induced potassium lass D. W. Seldin 9

SESSION II: PHARMACOLOGY AND , PHARMACOKINETICS

Antihypertensive effects of chronic treatment with muzolimine in experimental hypertension B. Garthofj, W.-D. Busse, S. Kazda and G. Luckhaus 23 Discussion 36 Effects of muzolimine in microperfusion studies of loops of Henle in rats J. Greven and B. Kölling 37 Discussion 46 Review of relevant pharmacokinetic data relating to muzolimine W. Ritter 48 Discussion 53 Contents

SESSION III: MUZOLIMINE IN PATIENTS WITH CARDIAC OEDEMAS

Dose titration of muzolimine in patients with cardiac oedema R.J. Madoery, G. Halsband, R. Spiritoso, H. Mosca and R.J. Esper 57 Discussion 62 Camparisan of the efficacy and tolerance of furosemide and muzolimine in patients with cardiac oedema E. Branco de Araujo, Jr., R. Faccioli, F. Mandarano, Jr. and H. Proenra 65 Discussion 73 Lang-term therapy with muzolimine in patients with chronic cardiac failure M. Studlar and F.O. Gruber 74 Discussion 79 Camparisan of effects of repeated single doses of muzolimine and piretanide in patients with cardiac failure. A single-blind controlled study P. Zardini, E. Uslenghi, B. Bianchini, B. Ottello and P. Salvini 81 Lang-term treatment with muzolimine in patients with cardiac oedema. An open study G. Ziakas, G. Zioutas, T. Arvanitidis and W. Zurukzoglu 92 Discussion 101 Urinary excretion of water and solutes and haemodynamic effects induced by muzolimine in patients with heart failure F. Tartagni and B. Magnani 103 Discussion 111 Haemodynamic effects of a single administration of muzolimine into the pulmonary artery E. G. Rovelli and M. Carnovali 112

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SESSION IV: MUZOLIMINE IN HYPERTENSIVE PATIENTS

Comparison of antihypertensive efficacy and tolerance of muzolimine and furosemide in a six-week controlled clinical study P. Jabur and S. Ferreira 119 Discussion 126 Comparison of the antihypertensive effects of methyldopa and muzolimine in arterial hypertension A. Pirrelli and M. Stella 127 Discussion 136 A comparison of muzolimine and indapamide in hypertension. Analysis of group data versus analysis of individual findings P. T. Scarpelli, S. Romano, C. Corti, F. Bigioli, E. Croppi, L. Scarpelli, M. Manne/li and A. Stinchetti 138 Comparison of muzolimine and indapamide in the treatment of high blood pressure G. Amabile, A. Egre, E. Perchicot and A. Serradimigni 149 Discussion 155 Long-term treatment with muzolimine in hypertensive patients A. Da/ Canton, D. Russo, R. Gallo, A. Papa, A. Caputo, C. Sjorza, A. Pepe and V.E. Andreucci 156 Discussion 165 Comparison of the effects of muzolimine and a fixed combination of hydrochlorothiazide and amiloride in mildly to moderately hypertensive patients P. Wicker and J. Clementy 168 Discussion 178 Efficacy and tolerance of long-term antihypertensive treatment with muzolimine. An open, multicentre trial M. Hanisch, H. Gansen and W. Gunsetmann 180 Discussion 193

VII Contents

Comparative study of muzolimine and chlorthalidone as antihypertensive drugs Ch. Nachev, II. Tomov, V. Vlahov, G. Stancousheva, J. Kaloianova, V. Ghergova, V. Ba/eva, A. Elencova, S. Tsolov, I. A tanassov and N. Bakracheva 195 Long-term treatment of mild to moderate hypertension with muzolimine A. Martins, A. Serra-Coelho, R. Soares, C. R,abaral, J. Carvalho and M. Carrageta 204 Discussion 208 Twenty-four-hour ambulatory profiles of blood pressure reduction following muzolimine M. Carrageta, R. Soares, A. Martins and A. Serra-Coelho 211 Discussion 215 Comparative clinical study of muzolimine (BAY g 2821) and furosemide in hypertension with chronic renal failure M. Lucsko, M. Chaignon, P. Aubert and J. Guedon 217 Discussion 229

SESSION V: MUZOLIMINE IN PATIENTS WITH HEPATOGENIC ASCITES ANDIN PATIENTS WITH CHRONIC RENAL FAlLURE

Treatment of oedema with a new diuretic A. Salta, R. Faedda, G. Soggia, N.A. 0/meo, L. Nieddu, G.F. Branca and E. Bartoli 235 Discussion 242 The use of muzolimine in chronic renal failure G. Orsoni, A. Di Felice, P. Cucudis, A. Vangelista, S. Stejoni and V. Bonomini 246 Discussion 256 Comparison of the diuretic effects of high doses of furosemide and muzolimine in patients with advanced chronic renal failure V. Mioli, M. Ragaiolo, E. Ohnmeiss and M. Carosi 259

VIII Contents

Discussion 267 Muzolimine in children with renal oedema. A pilot study R. Genova and A. Guerra 269 Discussion 276 The use of muzolimine in dialysis patients. A pilot study on dialysability and adsorption on aluminium hydroxide H. Mann, M. Hanisch and W. Ritter 277 Discussion 282 Study of interactions between muzolimine and furosemide in patients on maintenance haemodialysis E. Weissehedei and E. Ritz 283

D~~oo m Muzolimine in patients with decompensated renal insufficiency and oedema resistant to furosemide N. Belovezhdov, A. Astrug, V. Vlahov, D. Tzekova, M. Vretenarska and N. Bakracheva 292 Discussion 298

POSTER SESSIONS

Effects of muzolimine and furosemide in hypertensive pat:ients E. Angelucci, F. Capani, A. Dei Ponte, M. T. Guagnano and S. Sensi 301 Diuretic effects of muzolimine in patients with congestive heart failure. A comparison with furosemide L. Bartolucci, F. Canini, G. Antonelli, G. Vincenzoni, M. Formica, M. Carosi and C. Valori 306 Muzolimine in the treatment of uncontrolled essential arterial hypertension C. Beneitez 311 Comparison of the antihypertensive efficacy and acceptability of muzolimine and piretanide 0. de Divitiis, S. Di Somma, M. Petitto, S. Fazio, M. Galderisi and B. Villari 315

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The in vitra metabalism af muzalimine (BAY g 2:821) J. W. Gorrod and P.D. Messis 321 Efficacy and talerance af muzalimine in camparisan with furasemide in the treatment af cardiac aedema G. Montreuil and J. Jaillard 326 Camparisan af the antihypertensive and metabalilc effects af muzalimine and a cambinatian af hydrachlarathiazide and amilaride P. Strazzul/o, L.A. Ferrara, F. Galletti, Marcel/o Mancini, P. Mastranzo and M. Mancini 328 Clasing remarks V.E. Andreucci 335 Index af authars 337 Subject index 339

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