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EPA Abstract 629..712 European Psychiatry EPA 2020 Abstracts, Part 2 www.cambridge.org/epa Oral Communication Abstracts O0050 Construct and concurrent validity of illness and help-seeking behaviour scale Cite this article: (2020). EPA 2020 Abstracts, Part 2. European Psychiatry 63(S1), S629–S712. (IHSBS) in portuguese mental health patients https://doi.org/10.1192/j.eurpsy.2020.95 A. Macedo, C. Silva*, M.J. Soares, A. Araújo, A.T. Pereira, N. Madeira, D. Moura, M. Coroa, S. Morais, I. Rosendo and A.F. Miranda Portugal *Corresponding author. Introduction: Illness behaviour and Help-Seeking behaviour can have great impact on patient’s health and quality of life; therefore, it’s important to have an appropriate scale to assess these constructs. Objectives: To study the psychometric qualities of the IHSBS on Portuguese mental health patients, its reliability, its construct and concurrent validity, measured using the Stigma Scale (SS). Methods: The sample comprised 140 mental health patients, with different psychiatric diagnosis (70% women), with mean age of 39.49 years old (SD=15.71; V=18-78), followed in health centers and hospitals in the central area of the country. They filled out a questionnaire that included the SS and the IHSBS. Results: The KMO was .681 and Bartlett’s test p<.05. The analysis of the main components and scree plot revealed 3 components which was confirmed by Horn’s parallel analysis. The three factors were submitted to a varimax rotation - F1 is Help-Seeking Behaviour (EV=17.97%; α=.69), F2 Health Worries (EV=15.55%; α=.76), F3 Illness Behaviour (EV=9.01%; α=.68), all had acceptable internal consistency and so did the total scale EV=42.53%; α=.64). Four items were excluded: items 9, 16, 3 had inacceptable loadings in all dimensions and item 2 didn’t contribute for its sub-scale internal consistency. The correlation between IHSBS total score and its sub-scales ranged from .36 to .76 (p<.01); between F2 and the SS was .37 (p<.01) and between F3 and the SS was .19 (p<.05). Conclusions: The IHSBS is a valid and reliable instrument, that can be useful to assess Illness and Help-Seeking behaviour in mental health patients. Conflict of interest: No Keywords: IHSBS; Stigma; mental health O0058 Neurotoxic effects of varying doses of tramadol on the cerebral cortex of adult male wistar rats B. Adebisi* Nigeria *Corresponding author. Introduction: Tramadol is a centrally acting opiod analgesic used in the treatment of moderate to severe pain.There has been some concerns regarding the dependence liability of the long-term use of the drug. However, this present study is conducted to assess the histological toxicity profiles of long term use of Tramadol, in which the cerebral cortex is studied in adult male wistar rats. Objectives: The objective of the study aimed at validating the cognitive and behavioural © The Author(s), 2020. Published by Cambridge disorientations reported in humans, in addictive and long term use of Tramadol, by experimen- University Press on behalf of The European Psychiatry Association. This is an Open Access tation and histological representation of the toxic effects on the cerebral cortices of rats, treated article, distributed under the terms of the with different doses of the opioid. Creative Commons Attribution licence (http:// Methods: Twenty adult male wistar rats were subjected to experiment for sixty days. They were creativecommons.org/licenses/by/4.0/), which divided into four groups (A, B, C, and D). Group A serves as the control group and the rats in the permits unrestricted re-use, distribution, and group were administered with normal saline, while Groups B, C, and D received the dosages of reproduction in any medium, provided the original work is properly cited. Tramadol at 20, 30 and 40 mg/kg body weight respectively, daily, for sixty consecutive days. Thereafter, the animal were sacrificed, their brain excised and the brain tissues were processed for histological procedure and assesment. Results: Histology of brain tissues show varying extents of disorientations; damaged fibers, stunting cell processes of neurons, increase glial cell population and distorted cortical layers were some of the features seen on the cerebral cortex histology. S630 Oral Communication Conclusions: The toxic effects of Tramadol is evident on the Conflict of interest: No Cerebral cortex and should be kept in mind, even durng prescrip- Keywords: Thyroid hormones; schizophrenia; Clinical outcomes; tions by medical personnels. social security disability Conflict of interest: No Keywords: Cerebral cortex; Neurotoxic; tramadol; Neuronal O0087 dysfunction Analysis of microrna expressions in schizophrenia: Insights into molecular interactions and functional O0080 associations underpinning neurodevelopmental Associations between thyroid hormone levels and processes clinical outcomes in schizophrenic inpatients B.-Y. Chen*, J.-J. Lin, M.-K. Lu and S.-H. Lin M.J. Jung*, S.H. Lee, T.K. Lee and J.H. Choi Taiwan Korea, Republic of *Corresponding author. *Corresponding author. Introduction: MicroRNA (miRNA) can be regarded as one of Introduction: Thyroid hormone affects brain development and master regulators of neurodevelopment that displays genetic and deficiency of this hormone can induce psychiatric symptoms. This epigenetic roles that could therefore be affected by disease pro- shows a possible relationship between thyroid hormone and schizo- cesses. However, the differences of neurodevelopment-related miR- phrenia. NAs expression levels in schizophrenia patients, nonpsychotic Objectives: We examined the association between thyroid hor- relatives of schizophrenia patients and bipolar disorder patients mone levels and clinical outcomes in schizophrenic inpatients. remain unclear. Methods: Schizophrenic inpatients with no thyroid disease were Objectives: In this study, we aimed to investigate the aberrant studied. We assessed blood thyroid hormone levels and BPRS expression of miR-137 and miR-34 family in patients with schizo- scores in admission period. The presence of social security disability phrenia, then using canonical pathways analysis to identify ’ because of schizophrenia and the use of clozapine were also neurodevelopment-related miRNAs molecules roles and func- assessed. Collected data were analyzed using T-test and multiple tions. regression analysis. Methods: In the current study, we collected blood samples of Results: Three hundred thirty-eight patients were studied (Table 1). patients with schizophrenia (n = 215) and nonpsychotic controls No significant difference in mean age or gender ratio between (n = 100) as comparison groups. We examined the microRNAs groups was seen. The group with no treatment response and social expression levels in the different groups by receiver operating security disability showed lower free T4 levels (P<0.05) (Table 2). characteristic (ROC) curve and partial least squares-linear discrim- Conclusions: Free T4 level was significantly associated with treat- inant analysis (PLS-LDA). Moreover, the results of microRNAs ment response and the presence of social security disability from expressions were also uploaded into ingenuity pathway analysis schizophrenia. These relationships suggested that thyroid hormone system for core analysis and then overlaid with the canonical may be associated with the clinical outcomes of schizophrenia and pathways analysis. further analysis is required. Results: The miR-137 and miR-34 family expression levels presented significant expression patterns that could distinguish schizophrenia from nonpsychotic controls (p > 0.001). Annotating results from Table 1 Demographic and clinical characteristics real-time polymerase chain reaction (qPCR) experiments are N=338 Mean L-DOPA degradation (-log (p-value) = 2.81) and dopamine receptor signaling (-log (p-value) = 2.80). The bioinformatics results obtained Age (years) 49.6 through enrichment analyses to map miR-137 and miR-34 family BPRS score reduction rate (%) 13.0 related information with schizophrenia (p = 4.69E-9) and brain % lesion (p = 1.29E-8) for disease annotations. Conclusions: The findings provide further insights into the Male 54.4 neurodevelopment-related miRNAs expression levels as potential Clozapine use 16.0 peripheral blood biomarkers for schizophrenia. Social security disability 51.8 Table 2 Comparison of mean value of thyroid hormone level between Treatment response Social security disability Use of clozapine Yes No P Yes No P Yes No P TSH 1.50 2.45 .175 2.61 1.79 .172 1.76 2.30 .511 Total T3 1.10 1.05 .108 1.05 1.07 .336 1.01 1.07 .104 Free T4 1.38 1.25 .001* 1.25 1.32 .029* 1.26 1.29 .553 European Psychiatry S631 Conflict of interest: No Introduction: Worldwide increase in adolescent obesity is in stark Keywords: schizophrenia; microRNA; neurodevelopment; non- contrast with super thin ideal body size defined by modern societies. psychotic first-degree relatives; bipolar disorder Dieting has been widely promoted as a reliable method for main- taining ideal body weight(and shape) despite ample evidence on their in-effectivity and harmfulness to physical and mental wellbeing. O0108 Dieting is more prevalent amongst adolescent girls than boys. Objectives: Given that societal definitions of ideal body shape are The relation between changes in vitamin D and vitamin gender based, we investigated gender differences in exhibiting B12 levels, treatment characteristics, and outcome in mental distress given adolescents’ body size perception. methadone maintenance treatment patients Methods: Multinomial logistic
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