DOCSLIB.ORG

EPA Abstract 629..712

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text

Load more

European Psychiatry EPA 2020 Abstracts, Part 2 www.cambridge.org/epa Oral Communication Abstracts O0050 Construct and concurrent validity of illness and help-seeking behaviour scale Cite this article: (2020). EPA 2020 Abstracts, Part 2. European Psychiatry 63(S1), S629–S712. (IHSBS) in portuguese mental health patients https://doi.org/10.1192/j.eurpsy.2020.95 A. Macedo, C. Silva*, M.J. Soares, A. Araújo, A.T. Pereira, N. Madeira, D. Moura, M. Coroa, S. Morais, I. Rosendo and A.F. Miranda Portugal *Corresponding author. Introduction: Illness behaviour and Help-Seeking behaviour can have great impact on patient’s health and quality of life; therefore, it’s important to have an appropriate scale to assess these constructs. Objectives: To study the psychometric qualities of the IHSBS on Portuguese mental health patients, its reliability, its construct and concurrent validity, measured using the Stigma Scale (SS). Methods: The sample comprised 140 mental health patients, with different psychiatric diagnosis (70% women), with mean age of 39.49 years old (SD=15.71; V=18-78), followed in health centers and hospitals in the central area of the country. They filled out a questionnaire that included the SS and the IHSBS. Results: The KMO was .681 and Bartlett’s test p<.05. The analysis of the main components and scree plot revealed 3 components which was confirmed by Horn’s parallel analysis. The three factors were submitted to a varimax rotation - F1 is Help-Seeking Behaviour (EV=17.97%; α=.69), F2 Health Worries (EV=15.55%; α=.76), F3 Illness Behaviour (EV=9.01%; α=.68), all had acceptable internal consistency and so did the total scale EV=42.53%; α=.64). Four items were excluded: items 9, 16, 3 had inacceptable loadings in all dimensions and item 2 didn’t contribute for its sub-scale internal consistency. The correlation between IHSBS total score and its sub-scales ranged from .36 to .76 (p<.01); between F2 and the SS was .37 (p<.01) and between F3 and the SS was .19 (p<.05). Conclusions: The IHSBS is a valid and reliable instrument, that can be useful to assess Illness and Help-Seeking behaviour in mental health patients. Conflict of interest: No Keywords: IHSBS; Stigma; mental health O0058 Neurotoxic effects of varying doses of tramadol on the cerebral cortex of adult male wistar rats B. Adebisi* Nigeria *Corresponding author. Introduction: Tramadol is a centrally acting opiod analgesic used in the treatment of moderate to severe pain.There has been some concerns regarding the dependence liability of the long-term use of the drug. However, this present study is conducted to assess the histological toxicity profiles of long term use of Tramadol, in which the cerebral cortex is studied in adult male wistar rats. Objectives: The objective of the study aimed at validating the cognitive and behavioural © The Author(s), 2020. Published by Cambridge disorientations reported in humans, in addictive and long term use of Tramadol, by experimen- University Press on behalf of The European Psychiatry Association. This is an Open Access tation and histological representation of the toxic effects on the cerebral cortices of rats, treated article, distributed under the terms of the with different doses of the opioid. Creative Commons Attribution licence (http:// Methods: Twenty adult male wistar rats were subjected to experiment for sixty days. They were creativecommons.org/licenses/by/4.0/), which divided into four groups (A, B, C, and D). Group A serves as the control group and the rats in the permits unrestricted re-use, distribution, and group were administered with normal saline, while Groups B, C, and D received the dosages of reproduction in any medium, provided the original work is properly cited. Tramadol at 20, 30 and 40 mg/kg body weight respectively, daily, for sixty consecutive days. Thereafter, the animal were sacrificed, their brain excised and the brain tissues were processed for histological procedure and assesment. Results: Histology of brain tissues show varying extents of disorientations; damaged fibers, stunting cell processes of neurons, increase glial cell population and distorted cortical layers were some of the features seen on the cerebral cortex histology. S630 Oral Communication Conclusions: The toxic effects of Tramadol is evident on the Conflict of interest: No Cerebral cortex and should be kept in mind, even durng prescrip- Keywords: Thyroid hormones; schizophrenia; Clinical outcomes; tions by medical personnels. social security disability Conflict of interest: No Keywords: Cerebral cortex; Neurotoxic; tramadol; Neuronal O0087 dysfunction Analysis of microrna expressions in schizophrenia: Insights into molecular interactions and functional O0080 associations underpinning neurodevelopmental Associations between thyroid hormone levels and processes clinical outcomes in schizophrenic inpatients B.-Y. Chen*, J.-J. Lin, M.-K. Lu and S.-H. Lin M.J. Jung*, S.H. Lee, T.K. Lee and J.H. Choi Taiwan Korea, Republic of *Corresponding author. *Corresponding author. Introduction: MicroRNA (miRNA) can be regarded as one of Introduction: Thyroid hormone affects brain development and master regulators of neurodevelopment that displays genetic and deficiency of this hormone can induce psychiatric symptoms. This epigenetic roles that could therefore be affected by disease pro- shows a possible relationship between thyroid hormone and schizo- cesses. However, the differences of neurodevelopment-related miR- phrenia. NAs expression levels in schizophrenia patients, nonpsychotic Objectives: We examined the association between thyroid hor- relatives of schizophrenia patients and bipolar disorder patients mone levels and clinical outcomes in schizophrenic inpatients. remain unclear. Methods: Schizophrenic inpatients with no thyroid disease were Objectives: In this study, we aimed to investigate the aberrant studied. We assessed blood thyroid hormone levels and BPRS expression of miR-137 and miR-34 family in patients with schizo- scores in admission period. The presence of social security disability phrenia, then using canonical pathways analysis to identify ’ because of schizophrenia and the use of clozapine were also neurodevelopment-related miRNAs molecules roles and func- assessed. Collected data were analyzed using T-test and multiple tions. regression analysis. Methods: In the current study, we collected blood samples of Results: Three hundred thirty-eight patients were studied (Table 1). patients with schizophrenia (n = 215) and nonpsychotic controls No significant difference in mean age or gender ratio between (n = 100) as comparison groups. We examined the microRNAs groups was seen. The group with no treatment response and social expression levels in the different groups by receiver operating security disability showed lower free T4 levels (P<0.05) (Table 2). characteristic (ROC) curve and partial least squares-linear discrim- Conclusions: Free T4 level was significantly associated with treat- inant analysis (PLS-LDA). Moreover, the results of microRNAs ment response and the presence of social security disability from expressions were also uploaded into ingenuity pathway analysis schizophrenia. These relationships suggested that thyroid hormone system for core analysis and then overlaid with the canonical may be associated with the clinical outcomes of schizophrenia and pathways analysis. further analysis is required. Results: The miR-137 and miR-34 family expression levels presented significant expression patterns that could distinguish schizophrenia from nonpsychotic controls (p > 0.001). Annotating results from Table 1 Demographic and clinical characteristics real-time polymerase chain reaction (qPCR) experiments are N=338 Mean L-DOPA degradation (-log (p-value) = 2.81) and dopamine receptor signaling (-log (p-value) = 2.80). The bioinformatics results obtained Age (years) 49.6 through enrichment analyses to map miR-137 and miR-34 family BPRS score reduction rate (%) 13.0 related information with schizophrenia (p = 4.69E-9) and brain % lesion (p = 1.29E-8) for disease annotations. Conclusions: The findings provide further insights into the Male 54.4 neurodevelopment-related miRNAs expression levels as potential Clozapine use 16.0 peripheral blood biomarkers for schizophrenia. Social security disability 51.8 Table 2 Comparison of mean value of thyroid hormone level between Treatment response Social security disability Use of clozapine Yes No P Yes No P Yes No P TSH 1.50 2.45 .175 2.61 1.79 .172 1.76 2.30 .511 Total T3 1.10 1.05 .108 1.05 1.07 .336 1.01 1.07 .104 Free T4 1.38 1.25 .001* 1.25 1.32 .029* 1.26 1.29 .553 European Psychiatry S631 Conflict of interest: No Introduction: Worldwide increase in adolescent obesity is in stark Keywords: schizophrenia; microRNA; neurodevelopment; non- contrast with super thin ideal body size defined by modern societies. psychotic first-degree relatives; bipolar disorder Dieting has been widely promoted as a reliable method for main- taining ideal body weight(and shape) despite ample evidence on their in-effectivity and harmfulness to physical and mental wellbeing. O0108 Dieting is more prevalent amongst adolescent girls than boys. Objectives: Given that societal definitions of ideal body shape are The relation between changes in vitamin D and vitamin gender based, we investigated gender differences in exhibiting B12 levels, treatment characteristics, and outcome in mental distress given adolescents’ body size perception. methadone maintenance treatment patients Methods: Multinomial logistic
Recommended publications
  • Paranoid – Suspicious; Argumentative; Paranoid; Continually on The

    Paranoid – Suspicious; Argumentative; Paranoid; Continually on The

    Disorder Gathering 34, 36, 49 Answer Keys A N S W E R K E Y, Disorder Gathering 34 1. Avital Agoraphobia – 2. Ewelina Alcoholism – 3. Martyna Anorexia – 4. Clarissa Bipolar Personality Disorder –. 5. Lysette Bulimia – 6. Kev, Annabelle Co-Dependant Relationship – 7. Archer Cognitive Distortions / all-of-nothing thinking (Splitting) – 8. Josephine Cognitive Distortions / Mental Filter – 9. Mendel Cognitive Distortions / Disqualifying the Positive – 10. Melvira Cognitive Disorder / Labeling and Mislabeling – 11. Liat Cognitive Disorder / Personalization – 12. Noa Cognitive Disorder / Narcissistic Rage – 13. Regev Delusional Disorder – 14. Connor Dependant Relationship – 15. Moira Dissociative Amnesia / Psychogenic Amnesia – (*Jason Bourne character) 16. Eylam Dissociative Fugue / Psychogenic Fugue – 17. Amit Dissociative Identity Disorder / Multiple Personality Disorder – 18. Liam Echolalia – 19. Dax Factitous Disorder – 20. Lorna Neurotic Fear of the Future – 21. Ciaran Ganser Syndrome – 22. Jean-Pierre Korsakoff’s Syndrome – 23. Ivor Neurotic Paranoia – 24. Tucker Persecutory Delusions / Querulant Delusions – 25. Lewis Post-Traumatic Stress Disorder – 26. Abdul Proprioception – 27. Alisa Repressed Memories – 28. Kirk Schizophrenia – 29. Trevor Self-Victimization – 30. Jerome Shame-based Personality – 31. Aimee Stockholm Syndrome – 32. Delphine Taijin kyofusho (Japanese culture-specific syndrome) – 33. Lyndon Tourette’s Syndrome – 34. Adar Social phobias – A N S W E R K E Y, Disorder Gathering 36 Adjustment Disorder – BERKELEY Apotemnophilia
  • Journal of Neuroradiology

    Journal of Neuroradiology

    JOURNAL OF NEURORADIOLOGY AUTHOR INFORMATION PACK TABLE OF CONTENTS XXX . • Description p.1 • Impact Factor p.1 • Abstracting and Indexing p.2 • Editorial Board p.2 • Guide for Authors p.4 ISSN: 0150-9861 DESCRIPTION . The Journal of Neuroradiology is a peer-reviewed journal, publishing worldwide clinical and basic research in the field of diagnostic and Interventional neuroradiology, translational and molecular neuroimaging, and artificial intelligence in neuroradiology. The Journal of Neuroradiology considers for publication articles, reviews, technical notes and letters to the editors (correspondence section), provided that the methodology and scientific content are of high quality, and that the results will have substantial clinical impact and/or physiological importance. All manuscripts submitted to the Journal of Neuroradiology are first evaluated by the Editor-in-Chief and/or the Associate Editors to see if they are suitable for a peer-review . If yes, then the manuscript is send for peer review by international experts, and must:Be clear and easy to understand, precise and concise;Bring new, interesting, valid information - and improve clinical care or guide future research; Be solely the work of the author(s) stated; Not have been previously published elsewhere and not be under consideration by another journal; Be in accordance with the journal's Guide for Authors' instructions. Under no circumstances does the journal guarantee publication before the editorial board makes its final decision. 2020 Impact Factor: 3.447, 2020 Journal Citation Reports (Clarivate Analytics, 2021) 6 issues/year IMPACT FACTOR . 2020: 3.447 © Clarivate Analytics Journal Citation Reports 2021 AUTHOR INFORMATION PACK 2 Oct 2021 www.elsevier.com/locate/neurad 1 ABSTRACTING AND INDEXING .
  • PAH Neurology, Neurosurgery, Neuroradiology

    PAH Neurology, Neurosurgery, Neuroradiology

    Provided by: PAH Neurology, NeuroSurgery, NeuroRadiology (NNN) Case Conference 2018-2020 PAH Neurology, NeuroSurgery, NeuroRadiology (NNN) Case Conference 2018-20202019 - 8/6/2019 August 8, 2019 1:00 PM - 2:00 PM Penn Neurologic Institute, 330 South 9th Street, 2nd Floor Conference Room Target Audience This program has been designed for Neurology, Neurological Surgery, Psychiatry, Surgery, Psychiatry And Neurology - Addiction Psychiatry, Psychiatry And Neurology - Brain Injury Medicine, Psychiatry And Neurology - Child And Adolescent Psychiatry, Psychiatry And Neurology - Epilepsy, Psychiatry And Neurology - Forensic Psychiatry, Psychiatry And Neurology - Geriatric Psychiatry, Psychiatry And Neurology - Clinical Neurophysiology, Psychiatry And Neurology - Consultation-Liaison Psychiatry, Psychiatry And Neurology - Neuromuscular Medicine, Psychiatry And Neurology - Pain Medicine, Psychiatry And Neurology - Sleep Medicine, Psychiatry And Neurology - Vascular Neurology, Radiology - Neuroradiology, Psychiatry And Neurology - Hospice And Palliative Medicine, Psychiatry And Neurology - Neurodevelopmental Disabilities Series Educational Objectives After participating in this regularly scheduled series, participants should be able to: 1 Correctly identify any of the entities discussed during the session when encountered in clinical practice. 2 List the appropriate imaging modalities required for diagnostic clarification, whenever the clinical syndrome is non-specific. 3 Correctly associate imaging findings discussed during the session with specific
  • Careers in Medicine 101

    Careers in Medicine 101

    Careers in Medicine 101 1/25/12 Joanne Lynn, MD Disclaimer You are NOT expected to choose a career today, tomorrow or this year Getting Started on Career Selection • Spend Time Reflecting on your talents • Develop a List of Possible Interests • Explore WIDELY – Avoid Confirmation Bias • Study Hard and Do Well – Your patients need this from you – Your residency will be easier – You will have more options Reflect: How Will You Serve? Talents & Interests Key Questions • Where do I get my energy? – Thinking? Doing? Combo? • How do I like to interact with people? – Longitudinally? Episodically? • Do I have unique time pressures? • What are my unique talents? – Relationships? Problem Solving? Vision and Strategy? Creativity? Technical Skills? • What will my life outside of medicine look like? – How many hours do I expect to work? – What else will I be committed to? Medicine today is Extraordinarily Flexible Talents can be used in many different disciplines Good at Relationships? Interested in Wellness? Primary Care • Pediatrics • Family Medicine • Internal Medicine --and— • Alternative and Complementary Medicine • Occupational Medicine Like to Solve Puzzles? Diagnostic and Therapeutic Dilemmas • Internal Medicine • Neurology • Pathology Like to use your Hands? Good at Video Games? Surgery Open Laparoscopic Robotic Endovascular Specialties Neurosurgery Neuroradiology Interventional Cardiology Peripheral Vascular Surgeon Interventional Radiology Endoscopic Specialties Gastroenterology Pulmonary Medicine Urology Interested in Electronics? Neurology:
  • The Effects of Antipsychotic Treatment on Metabolic Function: a Systematic Review and Network Meta-Analysis

    The Effects of Antipsychotic Treatment on Metabolic Function: a Systematic Review and Network Meta-Analysis

    The effects of antipsychotic treatment on metabolic function: a systematic review and network meta-analysis Toby Pillinger, Robert McCutcheon, Luke Vano, Katherine Beck, Guy Hindley, Atheeshaan Arumuham, Yuya Mizuno, Sridhar Natesan, Orestis Efthimiou, Andrea Cipriani, Oliver Howes ****PROTOCOL**** Review questions 1. What is the magnitude of metabolic dysregulation (defined as alterations in fasting glucose, total cholesterol, low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol, and triglyceride levels) and alterations in body weight and body mass index associated with short-term (‘acute’) antipsychotic treatment in individuals with schizophrenia? 2. Does baseline physiology (e.g. body weight) and demographics (e.g. age) of patients predict magnitude of antipsychotic-associated metabolic dysregulation? 3. Are alterations in metabolic parameters over time associated with alterations in degree of psychopathology? 1 Searches We plan to search EMBASE, PsycINFO, and MEDLINE from inception using the following terms: 1 (Acepromazine or Acetophenazine or Amisulpride or Aripiprazole or Asenapine or Benperidol or Blonanserin or Bromperidol or Butaperazine or Carpipramine or Chlorproethazine or Chlorpromazine or Chlorprothixene or Clocapramine or Clopenthixol or Clopentixol or Clothiapine or Clotiapine or Clozapine or Cyamemazine or Cyamepromazine or Dixyrazine or Droperidol or Fluanisone or Flupehenazine or Flupenthixol or Flupentixol or Fluphenazine or Fluspirilen or Fluspirilene or Haloperidol or Iloperidone
  • Cotard's Syndrome: Two Case Reports and a Brief Review of Literature

    Cotard's Syndrome: Two Case Reports and a Brief Review of Literature

    Published online: 2019-09-26 Case Report Cotard’s syndrome: Two case reports and a brief review of literature Sandeep Grover, Jitender Aneja, Sonali Mahajan, Sannidhya Varma Department of Psychiatry, Post Graduate Institute of Medical Education and Research, Chandigarh, India ABSTRACT Cotard’s syndrome is a rare neuropsychiatric condition in which the patient denies existence of one’s own body to the extent of delusions of immortality. One of the consequences of Cotard’s syndrome is self‑starvation because of negation of existence of self. Although Cotard’s syndrome has been reported to be associated with various organic conditions and other forms of psychopathology, it is less often reported to be seen in patients with catatonia. In this report we present two cases of Cotard’s syndrome, both of whom had associated self‑starvation and nutritional deficiencies and one of whom had associated catatonia. Key words: Catatonia, Cotard’s syndrome, depression Introduction Case Report Cotard’s syndrome is a rare neuropsychiatric condition Case 1 characterized by anxious melancholia, delusions Mr. B, 65‑year‑old retired teacher who was pre‑morbidly of non‑existence concerning one’s own body to the well adjusted with no family history of mental illness, extent of delusions of immortality.[1] It has been most with personal history of smoking cigarettes in dependent commonly seen in patients with severe depression. pattern for last 30 years presented with an insidious However, now it is thought to be less common possibly onset mental illness of one and half years duration due to early institution of treatment in patients precipitated by psychosocial stressors.
  • Partial Agreement in the Social and Public Health Field

    Partial Agreement in the Social and Public Health Field

    COUNCIL OF EUROPE COMMITTEE OF MINISTERS (PARTIAL AGREEMENT IN THE SOCIAL AND PUBLIC HEALTH FIELD) RESOLUTION AP (88) 2 ON THE CLASSIFICATION OF MEDICINES WHICH ARE OBTAINABLE ONLY ON MEDICAL PRESCRIPTION (Adopted by the Committee of Ministers on 22 September 1988 at the 419th meeting of the Ministers' Deputies, and superseding Resolution AP (82) 2) AND APPENDIX I Alphabetical list of medicines adopted by the Public Health Committee (Partial Agreement) updated to 1 July 1988 APPENDIX II Pharmaco-therapeutic classification of medicines appearing in the alphabetical list in Appendix I updated to 1 July 1988 RESOLUTION AP (88) 2 ON THE CLASSIFICATION OF MEDICINES WHICH ARE OBTAINABLE ONLY ON MEDICAL PRESCRIPTION (superseding Resolution AP (82) 2) (Adopted by the Committee of Ministers on 22 September 1988 at the 419th meeting of the Ministers' Deputies) The Representatives on the Committee of Ministers of Belgium, France, the Federal Republic of Germany, Italy, Luxembourg, the Netherlands and the United Kingdom of Great Britain and Northern Ireland, these states being parties to the Partial Agreement in the social and public health field, and the Representatives of Austria, Denmark, Ireland, Spain and Switzerland, states which have participated in the public health activities carried out within the above-mentioned Partial Agreement since 1 October 1974, 2 April 1968, 23 September 1969, 21 April 1988 and 5 May 1964, respectively, Considering that the aim of the Council of Europe is to achieve greater unity between its members and that this
  • Copyrighted Material

    Copyrighted Material

    Index Note: page numbers in italics refer to figures; those in bold to tables or boxes. abacavir 686 tolerability 536–537 children and adolescents 461 acamprosate vascular dementia 549 haematological 798, 805–807 alcohol dependence 397, 397, 402–403 see also donepezil; galantamine; hepatic impairment 636 eating disorders 669 rivastigmine HIV infection 680 re‐starting after non‐adherence 795 acetylcysteine (N‐acetylcysteine) learning disability 700 ACE inhibitors see angiotensin‐converting autism spectrum disorders 505 medication adherence and 788, 790 enzyme inhibitors obsessive compulsive disorder 364 Naranjo probability scale 811, 812 acetaldehyde 753 refractory schizophrenia 163 older people 525 acetaminophen, in dementia 564, 571 acetyl‐L‐carnitine 159 psychiatric see psychiatric adverse effects acetylcholinesterase (AChE) 529 activated partial thromboplastin time 805 renal impairment 647 acetylcholinesterase (AChE) acute intoxication see intoxication, acute see also teratogenicity inhibitors 529–543, 530–531 acute kidney injury 647 affective disorders adverse effects 537–538, 539 acutely disturbed behaviour 54–64 caffeine consumption 762 Alzheimer’s disease 529–543, 544, 576 intoxication with street drugs 56, 450 non‐psychotropics causing 808, atrial fibrillation 720 rapid tranquillisation 54–59 809, 810 clinical guidelines 544, 551, 551 acute mania see mania, acute stupor 107, 108, 109 combination therapy 536 addictions 385–457 see also bipolar disorder; depression; delirium 675 S‐adenosyl‐l‐methionine 275 mania dosing 535 ADHD
  • Monothematic Delusions: Towards a Two-Factor Account Davies, Martin, 1950- Coltheart, Max

    Monothematic Delusions: Towards a Two-Factor Account Davies, Martin, 1950- Coltheart, Max

    Monothematic Delusions: Towards a Two-Factor Account Davies, Martin, 1950- Coltheart, Max. Langdon, Robyn. Breen, Nora. Philosophy, Psychiatry, & Psychology, Volume 8, Number 2/3, June/September 2001, pp. 133-158 (Article) Published by The Johns Hopkins University Press DOI: 10.1353/ppp.2001.0007 For additional information about this article http://muse.jhu.edu/journals/ppp/summary/v008/8.2davies.html Access Provided by Australian National University at 08/06/11 11:33PM GMT DAVIES, COLTHEART, LANGDON, AND BREEN / Monothematic Delusions I 133 Monothematic Delusions: Towards a Two-Factor Account Martin Davies, Max Coltheart, Robyn Langdon, and Nora Breen ABSTRACT: We provide a battery of examples of delu- There is more than one idea here, and the sions against which theoretical accounts can be tested. definition offered by the American Psychiatric Then we identify neuropsychological anomalies that Association’s Diagnostic and Statistical Manual could produce the unusual experiences that may lead, of Mental Disorders (DSM) seems to be based on in turn, to the delusions in our battery. However, we argue against Maher’s view that delusions are false something similar to the second part of the OED beliefs that arise as normal responses to anomalous entry: experiences. We propose, instead, that a second factor Delusion: A false belief based on incorrect inference is required to account for the transition from unusual about external reality that is firmly sustained despite experience to delusional belief. The second factor in what almost everyone else believes and despite what the etiology of delusions can be described superficial- constitutes incontrovertible and obvious proof or evi- ly as a loss of the ability to reject a candidate for belief dence to the contrary (American Psychiatric Associa- on the grounds of its implausibility and its inconsis- tion 1994, 765).
  • WCN19 Journal Posters Part 2 Revised V1

    WCN19 Journal Posters Part 2 Revised V1

    JNS-0000116542; No. of Pages 131 ARTICLE IN PRESS Journal of the Neurological Sciences (2019) xxx–xxx Contents lists available at ScienceDirect Journal of the Neurological Sciences journal homepage: www.elsevier.com/locate/jns WCN19 Journal Posters Part 2 revised_V1 WCN19-2260 WCN19-2269 Poster shift 01 - Channelopathies /neuroethics /neurooncology / Poster shift 01 - Channelopathies /neuroethics /neurooncology / pain - Part I /sleep disorders - Part I /stem cells and gene therapy - pain - Part I /sleep disorders - Part I /stem cells and gene therapy - Part I /stroke /training in neurology - Part I and traumatic brain Part I /stroke /training in neurology - Part I and traumatic brain injury injury Numb chin syndrome- The first finding in metastatic malignancy Results of surgical treatment in patients with moyamoya disease considering CT-perfusion imaging study N. Mustafayev, A. Bayrakoglu, F. Ilgen Uslu, M. Kolukısa Bezmialem University, Neurology, Istanbul, Turkey O. Harmatinaa, V. Morozb, I. Skorokhodab, I. Tyshb, N. Shahinb,R. Hanemb, U. Maliarb a Numb chin syndrome (NCS) is a sensory neuropathy of the SI «Romodanov Institute of Neurosurgery of NAMS of Ukraine», mental nerve, which is accompanied by hypoesthesia and paresthe- Neuroradiology Department, Kyiv, Ukraine b sia of the jaw and lower lip. Although being well known in neurology SI «Romodanov Institute of Neurosurgery of NAMS of Ukraine», practice, most of the physicians who have not experienced this Emergency Department of Vascular Neurosurgery, Kyiv, Ukraine phenomenon are unaware of this phenomenon since it is rare and can be confused with somatic complaints. This case report aims to Aim point out that NCS may be the first sign and symptom of metastatic To improve the results of surgical treatment of patients with cancers in patients who are not diagnosed.
  • Dottorato Di Ricerca the Effect of Finasteride

    Dottorato Di Ricerca the Effect of Finasteride

    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by UniCA Eprints Università degli Studi di Cagliari DOTTORATO DI RICERCA Scuola di Dottorato in Neuroscienze e Scienze Morfologiche Corso di Dottorato in Neuroscienze Ciclo XXIII THE EFFECT OF FINASTERIDE IN TOURETTE SYNDROME: RESULTS OF A CLINICAL TRIAL Settore scientifico disciplinari di afferenza BIO/14 Presentata da: Silvia Paba Coordinatore Dottorato Prof.ssa Alessandra Concas Tutor Dott.ssa Paola Devoto Esame finale anno accademico 2009 - 2010 1. INTRODUCTION 1 1.1 General characteristics of steroid 5α-reductase 2 1.2 S5αR inhibitors 15 1.3 S5αR inhibitors as putative therapeutic agents for some neuropsychiatric disorders. 23 2. AIMS OF THE STUDY 37 3. METHODS 38 3.1 Subjects 38 3.2 Procedures 39 3.3 Data analysis 40 4. RESULTS 41 4.1 Description of sample 41 4.2 Dosing, range and compliance 41 4.3 Effects of finasteride on TS and tic severity 44 4.4 Effects of finasteride on obsessive compulsive symptoms 46 4.5 Adverse effects 47 5. DISCUSSION 48 6. CONCLUSION 52 REFERENCES 54 1. INTRODUCTION The enzyme steroid 5α reductase (S5αR) catalyzes the conversion of Δ4-3-ketosteroid precursors - such as testosterone, progesterone and androstenedione - into their 5α- reduced metabolites. Although the current nomenclature assigns five enzymes to the S5αR family, only the types 1 and 2 appear to play an important role in steroidogenesis, mediating an overlapping set of reactions, albeit with distinct chemical characteristics and anatomical distribution. The discovery that the 5α-reduced metabolite of testosterone, 5α-dihydrotestosterone (DHT), is the most potent androgen and stimulates prostatic growth led to the development of S5αR inhibitors with high efficacy and tolerability.
  • Cotard's Syndrome

    Cotard's Syndrome

    MIND & BRAIN, THE JOURNAL OF PSYCHIATRY REVIEW ARTICLE Cotard’s Syndrome Hans Debruyne1,2,3, Michael Portzky1, Kathelijne Peremans1 and Kurt Audenaert1 Affiliations: 1Department of Psychiatry, University Hospital Ghent, Ghent, Belgium; 2PC Dr. Guislain, Psychiatric Hospital, Ghent, Belgium and 3Department of Psychiatry, Zorgsaam/RGC, Terneuzen, The Netherlands ABSTRACT Cotard’s syndrome is characterized by nihilistic delusions focused on the individual’s body including loss of body parts, being dead, or not existing at all. The syndrome as such is neither mentioned in DSM-IV-TR nor in ICD-10. There is growing unanimity that Cotard’s syndrome with its typical nihilistic delusions externalizes an underlying disorder. Despite the fact that Cotard’s syndrome is not a diagnostic entity in our current classification systems, recognition of the syndrome and a specific approach toward the patient is mandatory. This paper overviews the historical aspects, clinical characteristics, classification, epidemiology, and etiological issues and includes recent views on pathogenesis and neuroimaging. A short overview of treatment options will be discussed. Keywords: Cotard’s syndrome, nihilistic delusion, misidentification syndrome, review Correspondence: Hans Debruyne, P.C. Dr. Guislain Psychiatric Hospital Ghent, Fr. Ferrerlaan 88A, 9000 Ghent, Belgium. Tel: 32 9 216 3311; Fax: 32 9 2163312; e-mail: [email protected] INTRODUCTION: HISTORICAL ASPECTS AND of the syndrome. They described a nongeneralized de´lire de CLASSIFICATION negation, associated with paralysis, alcoholic psychosis, dementia, and the ‘‘real’’ Cotard’s syndrome, only found in Cotard’s syndrome is named after Jules Cotard (1840Á1889), anxious melancholia and chronic hypochondria.6 Later, in a French neurologist who described this condition for the 1968, Saavedra proposed a classification into three types: first time in 1880, in a case report of a 43-year-old woman.