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Home , CAPZA2, CDH8, Contactin 1, CSRP1, DSC2, Enolase 2

Table 1: List of four hundred and twenty variant identified

symbol description ENSMUSG00000058013|ENSMUST00000074733|ENSMUSP septin 11, isoform 00000074293_s2_e1277_1_rf0_c1_n0| NULL CRA_b ENSMUSG00000025176|ENSMUST00000081714|ENSMUSP RIKEN cDNA 00000080414_s2_e965_1_rf0_c1_n0| 0610010D20Rik 0610010D20 interferon ENSMUSG00000021208|ENSMUST00000044687|ENSMUSP stimulated gene 00000041712_s2_e851_1_rf0_c1_n0| 1810023F06Rik 12(b2) ENSMUSG00000036938|ENSMUST00000064324|ENSMUSP RIKEN cDNA 00000064498_s2_e740_1_rf0_c1_n0| 1810049H19Rik 1810049H19 gene RIKEN cDNA ENSMUSG00000061306|ENSMUST00000045402|ENSMUSP 1810073N04, 00000048675_s2_e3272_1_rf0_c1_n0| 1810073N04Rik isoform CRA_ ENSMUSG00000039879|ENSMUST00000020002|ENSMUSP mCG7517, isoform 00000020002_s2_e314_1_rf0_c1_n0| 3110003A17Rik CRA_c novel hypothetical protein LOC106894 M18C4209_1_s2543_e2729_1_rf1_c1_n0| A630042L21Rik isoform 2 variant ABI gene family, member 3 (NESH) ENSMUSG00000035258|ENSMUST00000048280|ENSMUSP binding protein 00000040830_s2_e2729_1_rf0_c1_n0| Abi3bp isoform 1 acetyl-Coenzyme A M17C923_1_s128_e1337_1_rf2_c1_n0| Acat2 acetyltransferase 2 novel beta MXC1985_1_s2_e593_1_rf1_c1_n0| Actb variant ENSMUSG00000029580|ENSMUST00000031564|ENSMUSP actin, gamma, 00000031564_s2_e1127_1_rf0_c1_n0| Actg cytoplasmic 1 acylphosphatase 1, erythrocyte ENSMUSG00000008822|ENSMUST00000008966|ENSMUSP (common) type, 00000008966_s2_e299_1_rf0_c1_n0| Acyp1 isoform CRA_b a disintegrin and metallopeptidase domain 9 (meltrin ENSMUSG00000031555|ENSMUST00000084032|ENSMUSP gamma), isoform 00000081045_s2_e2525_1_rf0_c1_n0| Adam9 CRA_b afamin, isoform M5C6453_2_s35_e1868_1_rf1_c1_n0| Afm CRA_d novel variant of M5C6460_1_s86_e1988_1_rf0_c1_n0| Afp alpha fetoprotein Angiotensinogen (serpin peptidase ENSMUSG00000031980|ENSMUST00000063278|ENSMUSP inhibitor, clade A, 00000066488_s2_e1448_1_rf0_c1_n0| Agt member 8 AHNAK ENSMUSG00000069833|ENSMUST00000088050|ENSMUSP 00000085366_s2_e6311_1_rf0_c1_n0| Ahnak isoform 1 novel alpha-2-HS- M16C2151_19_s71_e740_1_rf2_c1_n0| Ahsg variant novel alpha-2-HS- M16C2151_59_s749_e1013_1_rf0_c1_n0| Ahsg glycoprotein variant novel alpha-2-HS- M16C2151_75_s77_e959_1_rf1_c1_n0| Ahsg glycoprotein variant alpha-2-HS- glycoprotein, M16C2151_9_s71_e848_1_rf2_c1_n0| Ahsg isoform CRA_d novel alpha-2-HS- M16C2153_1_s11_e218_1_rf1_c1_n0| Ahsg glycoprotein variant alpha-2-HS- glycoprotein, M16C2153_2_s2_e131_1_rf0_c1_n0| Ahsg isoform CRA_a M16C2151_6_s71_e710_1_rf2_c1_n0| Ahsg alpha-2-HS- glycoprotein, isoform CRA_b A kinase (PRKA) anchor protein ENSMUSG00000038587|ENSMUST00000045730|ENSMUSP (gravin) 12, isoform 00000035829_s2_e5054_1_rf0_c1_n0| Akap12 CRA_b M5C6439_16_s2_e365_1_rf1_c1_n0| Alb novel albumin M5C6439_17_s2_e317_1_rf1_c1_n0| Alb variant novel aldolase 3 C M11C7819_20_s1118_e1505_1_rf0_c1_n0| Aldoc variant mCG11265, isoform M3C7934_37_s1637_e1856_1_rf2_c1_n0| Amy2a CRA_a amylase 2, M3C7934_23_s2_e1376_1_rf2_c1_n0| Amy2a pancreatic ENSMUSG00000024659|ENSMUST00000025561|ENSMUSP A1, isoform 00000025561_s2_e1040_1_rf0_c1_n0| Anxa1 CRA_b ENSMUSG00000006651|ENSMUST00000006828|ENSMUSP amyloid precursor- 00000006828_s2_e1964_1_rf0_c1_n0| Aplp1 like protein 1 novel apolipoprotein a1 M9C3524_2_s2_e758_1_rf0_c1_n0| Apoa1 variant novel apolipoprotein a1 M9C3525_1_s296_e563_1_rf1_c1_n0| Apoa1 variant novel apolipoprotein A-I M9C3524_4_s2_e758_1_rf2_c1_n0| Apoa1 variant novel apolipoprotein A-I M9C3524_5_s2_e710_1_rf0_c1_n0| Apoa1 variant novel apolipoprotein A-I M9C3524_8_s11_e899_1_rf2_c1_n0| Apoa1 variant novel apolipoprotein a4 M9C3532_2_s281_e1313_1_rf0_c1_n0| Apoa4 variant ENSMUSG00000020609|ENSMUST00000072432|ENSMUSP 00000072259_s2_e11132_1_rf0_c1_n0| Apob apolipoprotein b M12C479_3_s83_e13646_1_rf2_c1_n0| Apob apolipoprotein B novel apolipoprotein c3 M9C3528_4_s23_e284_1_rf1_c1_n0| Apoc3 variant apolipoprotein E, M7C1596_28_s155_e533_1_rf0_c1_n0| Apoe isoform CRA_c novel apolipoprotein e M7C1596_30_s362_e638_1_rf2_c1_n0| Apoe variant ATH1, acid trehalase-like 1 ENSMUSG00000062031|ENSMUST00000079403|ENSMUSP (yeast), isoform 00000078372_s2_e2072_1_rf0_c1_n0| Athl1 CRA_a ENSMUSG00000030847|ENSMUST00000033136|ENSMUSP Bcl2-associated 00000033136_s2_e1733_1_rf0_c1_n0| Bag3 athanogene 3 biliverdin reductase M7C2431_1_s5_e758_1_rf2_c1_n0| blvrb B bone morphogenetic ENSMUSG00000022098|ENSMUST00000022693|ENSMUSP protein 1, isoform 00000022693_s2_e2975_1_rf0_c1_n0| Bmp1 CRA_a ENSMUSG00000020490|ENSMUST00000020792|ENSMUSP butyrophilin related 00000020792_s2_e827_1_rf0_c1_n0| Butr1 1 isoform a complement component 1, r M6C9766_6_s2_e2180_1_rf1_c1_n0| C1r subcomponent M6C9766_7_s392_e2513_1_rf2_c1_n0| C1r mCG141466 ENSMUSG00000038521|ENSMUST00000077416|ENSMUSP mCG134312, 00000076632_s2_e2084_1_rf0_c1_n0| C1s isoform CRA_a complement component 3, M17C6514_1_s2_e5090_1_rf2_c1_n0| C3 isoform CRA_e complement component 3, M17C6514_13_s2_e2045_1_rf2_c1_n0| C3 isoform CRA_a novel complement M17C6514_5_s2_e3413_1_rf2_c1_n0| C3 c3 variant complement component 3, M17C6514_4_s2_e3761_1_rf2_c1_n0| C3 isoform CRA_c ENSMUSG00000015451|ENSMUST00000015595|ENSMUSP mCG15916, isoform 00000015595_s2_e5204_1_rf0_c1_n0| C4a CRA_b ENSMUSG00000073418|ENSMUST00000069507|ENSMUSP mCG15916, isoform 00000069418_s2_e5216_1_rf0_c1_n0| C4a CRA_c complement M17C4095_23_s2372_e2540_1_rf1_c1_n0| C4b component 4B complement M15C129_1_s122_e2471_1_rf1_c1_n0| C6 component 6 complement M15C129_2_s200_e2369_1_rf2_c1_n0| C6 component 6 PREDICTED: similar to Complement M15C139_1_s2_e2540_1_rf2_c1_n0| C7 component 7 complement component 8, alpha ENSMUSG00000035031|ENSMUST00000048947|ENSMUSP polypeptide, 00000047606_s2_e1763_1_rf0_c1_n0| C8a isoform CRA_c complement ENSMUSG00000029656|ENSMUST00000031663|ENSMUSP component 8, beta 00000031663_s2_e1769_1_rf0_c1_n0| C8b subunit complement component 8, ENSMUSG00000015083|ENSMUST00000040042|ENSMUSP gamma subunit, 00000041855_s2_e608_1_rf0_c1_n0| C8g isoform CRA_b calcium channel, voltage-dependent, ENSMUSG00000040118|ENSMUST00000039370|ENSMUSP alpha2/delta subunit 00000049457_s2_e3311_1_rf0_c1_n0| Cacna2d1 1 isoform d calcium channel, voltage-dependent, alpha 2/delta ENSMUSG00000010066|ENSMUST00000010210|ENSMUSP subunit 2, isoform 00000010210_s2_e3464_1_rf0_c1_n0| Cacna2d2 CRA_b synaptic cell ENSMUSG00000032076|ENSMUST00000034581|ENSMUSP adhesion molecule 1 00000034581_s2_e1253_1_rf0_c1_n0| Cadm1 isoform 5 ENSMUSG00000029761|ENSMUST00000031775|ENSMUSP 00000031775_s2_e1538_1_rf0_c1_n0| Cald1 caldesmon 1 novel capping protein (actin filament) muscle Z- M6C861_14_s2_e158_1_rf1_c1_n0| Capz2 line variant ENSMUSG00000027556|ENSMUST00000029072|ENSMUSP 00000029072_s2_e785_1_rf0_c1_n0| Car1 1 ENSMUSG00000021585|ENSMUST00000065629|ENSMUSP calpastatin, isoform 00000065275_s2_e2264_1_rf0_c1_n0| Cast CRA_a RIKEN cDNA ENSMUSG00000050786|ENSMUST00000055559|ENSMUSP 6330407D12, 00000058077_s2_e422_1_rf0_c1_n0| Ccdc126 isoform CRA_a ENSMUSG00000005087|ENSMUST00000005218|ENSMUSP CD44 antigen, 00000005218_s2_e2342_1_rf0_c1_n0| Cd44 isoform CRA_e CD47 antigen (Rh- related antigen, -associated ENSMUSG00000055447|ENSMUST00000023320|ENSMUSP signal transducer), 00000023320_s2_e974_1_rf0_c1_n0| Cd47 isoform CRA_b ENSMUSG00000015355|ENSMUST00000068584|ENSMUSP CD48 antigen, 00000064241_s2_e722_1_rf0_c1_n0| Cd48 isoform CRA_b M3C4571_2_s260_e572_1_rf0_c1_n0| Cd5l CD5 antigen-like ENSMUSG00000027435|ENSMUST00000099269|ENSMUSP 00000096876_s2_e1934_1_rf0_c1_n0| Cd93 CD93 antigen ENSMUSG00000002885|ENSMUST00000002964|ENSMUSP CD97 antigen, 00000002964_s2_e2174_1_rf0_c1_n0| Cd97 isoform CRA_a 8 isoform M8C7690_1_s692_e812_1_rf2_c1_n0| Cdh8 1 -related cell ENSMUSG00000074272|ENSMUST00000098666|ENSMUSP adhesion molecule 1 00000096263_s2_e1352_1_rf0_c1_n0| Ceacam1 isoform 4 ENSMUSG00000058952|ENSMUST00000098620|ENSMUSP novel cpmplement 00000096220_s2_e1805_1_rf0_c1_n0| Cf1 factor i variant complement factor M17C4115_21_s365_e1982_1_rf0_c1_n0| Cfb B, isoform CRA_b novel complement component M1C9426_3_s26_e914_1_rf1_c1_n0| Cfh variant novel complement component factor H M1C9441_5_s110_e3896_1_rf0_c1_n0| Cfh variant ENSMUSG00000057037|ENSMUST00000023965|ENSMUSP complement factor 00000023965_s2_e1031_1_rf0_c1_n0| Cfhr1 H-related 1 ENSMUSG00000058952|ENSMUST00000077918|ENSMUSP complement 00000077074_s2_e1811_1_rf0_c1_n0| Cfi component factor i Cofilin, non-muscle M19C627_16_s74_e689_1_rf0_c1_n0| Cfl isoform ENSMUSG00000027350|ENSMUST00000028826|ENSMUSP 00000028826_s2_e2033_1_rf0_c1_n0| Chgb chromogranin B chitinase 1 ENSMUSG00000026450|ENSMUST00000086475|ENSMUSP (chitotriosidase), 00000083666_s2_e1394_1_rf0_c1_n0| Chit1 isoform CRA_b cold inducible RNA binding protein, M10C5886_1_s77_e662_1_rf1_c1_n0| Cirbp isoform CRA_a clathrin, light polypeptide (Lca) M4C2601_3_s83_e344_1_rf1_c1_n0| Clta isoform d clathrin, light ENSMUSG00000047547|ENSMUST00000049575|ENSMUSP polypeptide (Lcb), 00000053371_s2_e689_1_rf0_c1_n0| Cltb isoform CRA_b ENSMUSG00000055022|ENSMUST00000000109|ENSMUSP 00000000109_s2_e3062_1_rf0_c1_n0| Cntn1 ENSMUSG00000027966|ENSMUST00000029582|ENSMUSP collagen, type XI, 00000029582_s2_e1229_1_rf0_c1_n0| Col11a1 alpha 1 ENSMUSG00000024330|ENSMUST00000076926|ENSMUSP collagen, type XI, 00000076193_s2_e5210_1_rf0_c1_n0| Col11a2 alpha 2 procollagen, type ENSMUSG00000032332|ENSMUST00000071750|ENSMUSP XII, alpha 1, 00000071662_s2_e9362_1_rf0_c1_n0| Col12a1 isoform CRA_b procollagen, type ENSMUSG00000028339|ENSMUST00000082303|ENSMUSP XV, isoform 00000080921_s2_e4109_1_rf0_c1_n0| Col15a1 CRA_a procollagen, type ENSMUSG00000001435|ENSMUST00000072755|ENSMUSP XVIII, alpha 1 00000072538_s2_e5324_1_rf0_c1_n0| Col18a1 isoform 1 novel collagen, type M11C9935_216_s128_e4526_1_rf0_c1_n0| Col11a1 1, alpha 1 variant procollagen, type M1C2622_11_s545_e1376_1_rf0_c1_n0| Col3a1 III, alpha 1isoform 1 ENSMUSG00000048126|ENSMUST00000056925|ENSMUSP mCG12867, isoform 00000057131_s2_e7970_1_rf0_c1_n0| Col6a3 CRA_b ceruloplasmin, M3C675_1_s2564_e2861_1_rf1_c1_n0| Cp isoform CRA_c ceruloplasmin, M3C675_3_s161_e3410_1_rf2_c1_n0| Cp isoform CRA_a novel ceruloplasmin M3C681_1_s275_e461_1_rf0_c1_n0| Cp variant ENSMUSG00000032060|ENSMUST00000034562|ENSMUSP crystallin, alpha B, 00000034562_s2_e527_1_rf0_c1_n0| Cryab isoform CRA_a colony stimulating ENSMUSG00000024621|ENSMUST00000025523|ENSMUSP factor 1 receptor, 00000025523_s2_e2933_1_rf0_c1_n0| Csf1r isoform CRA_c casein kinase 2, ENSMUSG00000046707|ENSMUST00000056919|ENSMUSP alpha prime 00000055919_s2_e1052_1_rf0_c1_n0| Csnk2a2 polypeptide and ENSMUSG00000026421|ENSMUST00000097561|ENSMUSP glycine-rich protein 00000095169_s2_e581_1_rf0_c1_n0| Csrp1 1, isoform CRA_a chitobiase, di-N- ENSMUSG00000028189|ENSMUST00000029840|ENSMUSP acetyl-, isoform 00000029840_s2_e938_1_rf0_c1_n0| Ctbs CRA_b ENSMUSG00000034101|ENSMUST00000036811|ENSMUSP , delta 1 00000042543_s2_e2549_1_rf0_c1_n0| Ctnnd1 isoform 4 ENSMUSG00000007891|ENSMUST00000008035|ENSMUSP D 00000008035_s2_e1334_1_rf0_c1_n0| Ctsd isoform c ENSMUSG00000031078|ENSMUST00000033402|ENSMUSP cortactin, isoform 00000033402_s2_e1640_1_rf0_c1_n0| Cttn CRA_a novel cytochrome c M6C11984_1_s2906_e3146_1_rf0_c1_n0| Cycs variant ENSMUSG00000039952|ENSMUST00000098395|ENSMUSP 00000095996_s2_e2681_1_rf0_c1_n0| Dag1 1 ENSMUSG00000026385|ENSMUST00000027634|ENSMUSP diazepam binding 00000027634_s2_e263_1_rf0_c1_n0| Dbi inhibitor isoform 1 ENSMUSG00000032040|ENSMUST00000034539|ENSMUSP decapping , 00000034539_s2_e1016_1_rf0_c1_n0| Dcps scavenger DEAD (Asp-Glu- ENSMUSG00000019432|ENSMUST00000068056|ENSMUSP Ala-Asp) box 00000070682_s2_e1286_1_rf0_c1_n0| Ddx39 polypeptide 39 novel DEAD (Asp- Glu-Ala-Asp) box polypeptide 6 M9C3191_1_s380_e587_1_rf2_c1_n0| Ddx6 variant dickkopf homolog 3 (Xenopus laevis), M7C10036_7_s68_e1148_1_rf1_c1_n0| Dkk3 isoform CRA_d dihydrolipoamide M12C1883_1_s2_e1661_1_rf0_c1_n0| Dld dehydrogenase ENSMUSG00000060962|ENSMUST00000054427|ENSMUSP 00000060362_s2_e1559_1_rf0_c1_n0| Dmkn dermokine-beta ENSMUSG00000033335|ENSMUST00000072362|ENSMUSP mCG14048, isoform 00000072199_s2_e2615_1_rf0_c1_n0| Dnm2 CRA_d ENSMUSG00000053687|ENSMUST00000034373|ENSMUSP mCG20478, isoform 00000034373_s2_e1430_1_rf0_c1_n0| Dpep2 CRA_a ENSMUSG00000044322|ENSMUST00000025187|ENSMUSP 1, 00000025187_s2_e2660_1_rf0_c1_n0| Dsc1 isoform CRA_b ENSMUSG00000024331|ENSMUST00000039247|ENSMUSP desmocollin 2, 00000042905_s2_e2546_1_rf0_c1_n0| Dsc2 isoform CRA_a PREDICTED: similar to M13C2563_1_s386_e8960_1_rf2_c1_n0| Dsp deoxyuridine ENSMUSG00000027203|ENSMUST00000051605|ENSMUSP triphosphatase, 00000057854_s2_e602_1_rf0_c1_n0| Dut isoform CRA_b ENSMUSG00000028108|ENSMUST00000074315|ENSMUSP 00000073924_s2_e1304_1_rf0_c1_n0| Ecm1 protein 1 extracellular matrix protein 1, isoform M3C6105_13_s107_e1808_1_rf0_c1_n0| Ecm1 CRA_b novel extra cellular matrix protein 1 M3C6105_9_s107_e1466_1_rf0_c1_n0| Ecm1 variant extracellular matrix ENSMUSG00000028108|ENSMUST00000029753|ENSMUSP protein 1, isoform 00000029753_s2_e1679_1_rf0_c1_n0| Ecm1 CRA_a eukaryotic ENSMUSG00000055762|ENSMUST00000073802|ENSMUSP elongation factor 1 00000073472_s2_e845_1_rf0_c1_n0| Eef1d delta isoform b epidermal growth factor-containing -like ENSMUSG00000020467|ENSMUST00000020759|ENSMUSP extracellular matrix 00000020759_s2_e1481_1_rf0_c1_n0| Efemp1 protein 1 epidermal growth factor-containing fibulin-like extracellular matrix ENSMUSG00000024909|ENSMUST00000025843|ENSMUSP protein 2, isoform 00000025843_s2_e1331_1_rf0_c1_n0| Efemp2 CRA_b epidermal growth ENSMUSG00000020122|ENSMUST00000020329|ENSMUSP factor receptor 00000020329_s2_e3632_1_rf0_c1_n0| Egfr isoform 1 Williams-Beuren syndrome region ENSMUSG00000040731|ENSMUST00000036125|ENSMUSP 1 homolog (), 00000048833_s2_e746_1_rf0_c1_n0| Eif4h isoform CRA_a eukaryotic ENSMUSG00000021282|ENSMUST00000050993|ENSMUSP translation initiation 00000061616_s2_e1289_1_rf0_c1_n0| Eif5 factor 5 eukaryotic ENSMUSG00000041070|ENSMUST00000071026|ENSMUSP translation initiation 00000068651_s2_e464_1_rf0_c1_n0| Eif5a factor 5A elastase 1, M15C7828_10_s131_e806_1_rf1_c1_n0| Ela1 pancreatic mCG19991, isoform M4C11288_1_s131_e992_1_rf1_c1_n0| Ela2a CRA_e ENSMUSG00000063524|ENSMUST00000080926|ENSMUSP similar to 1, 00000079727_s2_e1304_1_rf0_c1_n0| Eno1 alpha non- , gamma ENSMUSG00000004267|ENSMUST00000004378|ENSMUSP neuronal, isoform 00000004378_s2_e1304_1_rf0_c1_n0| Eno2 CRA_a ENSMUSG00000060600|ENSMUST00000072841|ENSMUSP enolase 3, beta 00000072620_s2_e1304_1_rf0_c1_n0| Eno3 muscle erythrocyte protein ENSMUSG00000022099|ENSMUST00000022694|ENSMUSP band 4.9, isoform 00000022694_s2_e1151_1_rf0_c1_n0| Epb4.9 CRA_b novel esterase 1 M8C7190_1_s53_e1790_1_rf2_c1_n0| Es1 variant mCG9583, isoform M8C7195_1_s2_e209_1_rf0_c1_n0| Es1 CRA_b ENSMUSG00000031444|ENSMUST00000033821|ENSMUSP 00000033821_s2_e1481_1_rf0_c1_n0| F10 F10 protein M13C4204_1_s1163_e1826_1_rf2_c1_n0| F12 novel factor 12 variant coagulation factor ENSMUSG00000039109|ENSMUST00000037491|ENSMUSP XIII, A1 subunit, 00000048667_s2_e2198_1_rf0_c1_n0| F13a1 isoform CRA_b coagulation factor ENSMUSG00000031443|ENSMUST00000033820|ENSMUSP VII, isoform 00000033820_s2_e1340_1_rf0_c1_n0| F7 CRA_b fatty acid binding M3C293_1_s2_e368_1_rf2_c1_n0| Fabp5 protein 5, epidermal fatty acid binding M18C5388_1_s2_e458_1_rf1_c1_n0| Fabp5 protein 5, epidermal phenylalanine- tRNA synthetase- ENSMUSG00000003808|ENSMUST00000003906|ENSMUSP like, alpha subunit, 00000003906_s2_e1526_1_rf0_c1_n0| Farsa isoform CRA_a novel F-box and leucine-rich repeat M15C1226_1_s899_e1028_1_rf2_c1_n0| Fbx17 protein 7 variant RIKEN cDNA ENSMUSG00000047730|ENSMUST00000098633|ENSMUSP 9530053A07, 00000096234_s2_e7529_1_rf0_c1_n0| Fcgbp isoform CRA_a ENSMUSG00000026656|ENSMUST00000027966|ENSMUSP mCG8629, isoform 00000027966_s2_e881_1_rf0_c1_n0| Fcgr2b CRA_c novel fetuin beta M16C2158_6_s209_e1046_1_rf1_c1_n0| Fetub variant novel M3C4196_1_s74_e1811_1_rf1_c1_n0| Fga alpha variant fibrinogen, alpha polypeptide, M3C4201_1_s2_e905_1_rf0_c1_n0| Fga isoform CRA_b novel fibrinogen, alpha polypeptide M3C4202_1_s2_e272_1_rf2_c1_n0| Fga variant ENSMUSG00000031594|ENSMUST00000034003|ENSMUSP fibrinogen-like 00000034003_s2_e944_1_rf0_c1_n0| Fgl1 protein 1 ENSMUSG00000032966|ENSMUST00000044011|ENSMUSP FK506 binding 00000037206_s2_e326_1_rf0_c1_n0| Fkbp1a protein 1a ENSMUSG00000031328|ENSMUST00000033699|ENSMUSP 00000033699_s2_e7943_1_rf0_c1_n0| Flna , alpha novel 1 M1C4590_702_s41_e6875_1_rf0_c1_n0| Fn1 variant novel fibronectin 1 M1C4590_768_s41_e6851_1_rf0_c1_n0| Fn1 variant ENSMUSG00000026193|ENSMUST00000055226|ENSMUSP fibronectin 1, 00000054499_s2_e7433_1_rf0_c1_n0| Fn1 isoform CRA_d ENSMUSG00000026193|ENSMUST00000087254|ENSMUSP fibronectin 1, 00000084509_s2_e6890_1_rf0_c1_n0| Fn1 isoform CRA_c FXYD domain- containing ion ENSMUSG00000059412|ENSMUST00000041005|ENSMUSP transport regulator 00000035429_s2_e194_1_rf0_c1_n0| Fxyd2 2, isoform CRA_a Ras-GTPase- activating protein SH3-domain- ENSMUSG00000018583|ENSMUST00000018727|ENSMUSP binding protein, 00000018727_s2_e1397_1_rf0_c1_n0| G3bp1 isoform CRA_b novel glyceraldehyde-3- phosphate dehydrogenase M3C108_1_s395_e980_1_rf1_c1_n0| Gapdh variant PREDICTED: similar to Glyceraldehyde-3- phosphate M6C7308_1_s170_e986_1_rf0_c1_n0| Gapdh dehydrogenase (GAPDH) isoform 1

novel Glyceraldehyde-3- phosphate dehydrogenase M15C4263_1_s20_e1016_1_rf1_c1_n0| Gapdh variant novel Glyceraldehyde-3- phosphate dehydrogenase M11C348_1_s1766_e2621_1_rf0_c1_n0| Gapdh variant M11C12722_1_s113_e1031_1_rf2_c1_n0| Gapdh mCG49456 novel glyceraldehyde-3- phsphate dehydrogenase M5C4343_1_s404_e584_1_rf0_c1_n0| Gapdh variant ENSMUSG00000058624|ENSMUST00000075494|ENSMUSP guanine deaminase, 00000074937_s2_e1364_1_rf0_c1_n0| Gda isoform CRA_a golgi associated, gamma adaptin ear M15C4912_1_s251_e335_1_rf1_c1_n0| Gga1 containing, gamma- ENSMUSG00000040471|ENSMUST00000076443|ENSMUSP glutamyltransferase 00000075773_s2_e1493_1_rf0_c1_n0| Ggt6 6, isoform CRA_a growth hormone M15C13_11_s47_e926_1_rf1_c1_n0| Ghr receptor isoform 1 ENSMUSG00000036098|ENSMUST00000096230|ENSMUSP gene model 98, 00000093946_s2_e1844_1_rf0_c1_n0| Gm98 (NCBI) golgi ENSMUSG00000021556|ENSMUST00000095739|ENSMUSP phosphoprotein 2, 00000093410_s2_e1181_1_rf0_c1_n0| Golm1 isoform CRA_a mCG22075, isoform M7C118_1_s2_e1001_1_rf0_c1_n0| GpVI CRA_b novel glutathione M11C4339_13_s332_e530_1_rf2_c1_n0| Gpx3 peoxidase variant granulin, isoform M11C11598_3_s479_e617_1_rf2_c1_n0| Grn CRA_d histocompatibility 2, K1, K region M17C4317_13_s2_e917_1_rf2_c1_n0| H2-K1 isoform 1 ENSMUSG00000061232|ENSMUST00000025181|ENSMUSP histocompatibility 2, 00000025181_s2_e1124_1_rf0_c1_n0| H2-K1 K1, K region ENSMUSG00000067235|ENSMUST00000068291|ENSMUSP MHC class I like 00000066419_s2_e977_1_rf0_c1_n0| H2-Q10 protein GS10 ENSMUSG00000054128|ENSMUST00000025312|ENSMUSP histocompatibility 2, 00000025312_s2_e1160_1_rf0_c1_n0| H2-T18 T region 3 hyaluronic acid M19C5841_1_s104_e1592_1_rf0_c1_n0| Habp2 binding protein 2 hemoglobin alpha M11C2347_9_s2_e254_1_rf0_c1_n0| Hba-a1 variant ENSMUSG00000069919|ENSMUST00000093208|ENSMUSP hemoglobin alpha, 00000090896_s2_e422_1_rf0_c1_n0| Hba-a1 adult chain 1 ENSMUSG00000069919|ENSMUST00000093209|ENSMUSP 00000090897_s2_e428_1_rf0_c1_n0| Hba-a1 hemoglobin alpha novel hemoglobin alpha, adult chain 2 M11C2347_4_s263_e383_1_rf1_c1_n0| Hba-a2 variant novel hemoglobin M11C2347_6_s17_e383_1_rf2_c1_n0| Hba-a2 alpha, adult chain 2 novel hemoglobin beta chain subunit M7C9167_6_s11_e539_1_rf0_c1_n0| Hbb variant novel M5C2929_10_s1346_e1892_1_rf1_c1_n0| Hgfac activator variant novel high mobility group protein B2 M18C3726_1_s2_e347_1_rf0_c1_n0| Hmgb2 variant ENSMUSG00000004980|ENSMUST00000069949|ENSMUSP mCG119114, 00000067491_s2_e905_1_rf0_c1_n0| Hnrnpa2b1 isoform CRA_a heterogeneous ENSMUSG00000066037|ENSMUST00000084218|ENSMUSP nuclear 00000081238_s2_e1145_1_rf0_c1_n0| Hnrnpr ribonucleoprotein R heterogeneous nuclear ENSMUSG00000007850|ENSMUST00000069304|ENSMUSP ribonucleoprotein 00000070503_s2_e1349_1_rf0_c1_n0| Hnrph1 H1, isoform CRA_b heterogeneous nuclear M13C4577_3_s191_e1592_1_rf2_c1_n0| Hnrpk ribonucleoprotein K heterogeneous nuclear ENSMUSG00000059208|ENSMUST00000087582|ENSMUSP ribonucleoprotein 00000084864_s2_e2072_1_rf0_c1_n0| Hnrpm M, isoform CRA_a novel hemopexin M8C8688_3_s53_e428_1_rf2_c1_n0| Hp variant novel hemopexin M7C9387_12_s2_e515_1_rf2_c1_n0| Hpx variant novel hemopexin M7C9387_17_s194_e1220_1_rf0_c1_n0| Hpx variant novel hemopexin M7C9387_19_s2_e1346_1_rf2_c1_n0| Hpx variant novel hemopexin M7C9387_1_s92_e434_1_rf1_c1_n0| Hpx variant hemopexin, isoform M7C9387_13_s2_e1013_1_rf1_c1_n0| Hpx CRA_b novel hemopexin M7C9387_2_s5_e392_1_rf2_c1_n0| Hpx variant novel hemopexin M7C9387_3_s2_e728_1_rf0_c1_n0| Hpx variant heat shock 70kD protein 5 (glucose- ENSMUSG00000026864|ENSMUST00000028222|ENSMUSP regulated protein), 00000028222_s2_e1967_1_rf0_c1_n0| Hspa5 isoform CRA_a perlecan (heparan ENSMUSG00000028763|ENSMUST00000030547|ENSMUSP sulfate proteoglycan 00000030547_s2_e11114_1_rf0_c1_n0| Hspg2 2) isocitrate ENSMUSG00000025950|ENSMUST00000027087|ENSMUSP dehydrogenase 1 00000027087_s2_e1265_1_rf0_c1_n0| Idh1 (NADP+), soluble interferon receptor 2 M16C6804_1_s320_e1076_1_rf0_c1_n0| Ifnrb isoform b precursor insulin-like growth ENSMUSG00000020053|ENSMUST00000062862|ENSMUSP factor 1 isoform 2 00000056668_s2_e497_1_rf0_c1_n0| Igf1 preproprotein insulin-like growth ENSMUSG00000048583|ENSMUST00000053222|ENSMUSP factor 2, isoform 00000052434_s2_e542_1_rf0_c1_n0| Igf2 CRA_a insulin-like growth factor binding ENSMUSG00000039323|ENSMUST00000047328|ENSMUSP protein 2, isoform 00000046610_s2_e917_1_rf0_c1_n0| Igfbp2 CRA_a insulin-like growth factor binding ENSMUSG00000026185|ENSMUST00000027377|ENSMUSP protein 5, isoform 00000027377_s2_e815_1_rf0_c1_n0| Igfbp5 CRA_b insulin-like growth ENSMUSG00000036256|ENSMUST00000046746|ENSMUSP factor binding 00000045057_s2_e848_1_rf0_c1_n0| Igfbp7 protein 7 interleukin 18 ENSMUSG00000070427|ENSMUST00000094134|ENSMUSP binding protein, 00000091685_s2_e581_1_rf0_c1_n0| Il18bp isoform CRA_a interleukin 1 ENSMUSG00000022514|ENSMUST00000023156|ENSMUSP receptor accessory 00000023156_s2_e1712_1_rf0_c1_n0| Il1rap a ENSMUSG00000031805|ENSMUST00000034261|ENSMUSP 00000034261_s2_e368_1_rf0_c1_n0| Insl3 insulin-like 3 inter alpha-trypsin inhibitor, heavy ENSMUSG00000021922|ENSMUST00000078490|ENSMUSP chain 4, isoform 00000077580_s2_e2708_1_rf0_c1_n0| Itih4 CRA_b inter alpha-trypsin inhibitor, heavy ENSMUSG00000021922|ENSMUST00000006703|ENSMUSP chain 4, isoform 00000006703_s2_e2828_1_rf0_c1_n0| Itih4 CRA_e KH-type splicing ENSMUSG00000007670|ENSMUST00000007814|ENSMUSP regulatory protein, 00000007814_s2_e2246_1_rf0_c1_n0| Khsrp isoform CRA_b ENSMUSG00000031640|ENSMUST00000026907|ENSMUSP B, plasma 00000026907_s2_e1916_1_rf0_c1_n0| Klkb1 1 ENSMUSG00000022875|ENSMUST00000023589|ENSMUSP -1 00000023589_s2_e1985_1_rf0_c1_n0| Kng1 isoform1 mCG128256, M16C2166_11_s191_e1385_1_rf0_c1_n0| Kng2 isoform CRA_a mCG128253, M16C2167_10_s107_e542_1_rf1_c1_n0| Kng3 isoform CRA_c kininogen 1 isoform M16C2167_12_s365_e800_1_rf0_c1_n0| Kng4 1 novel kininogen 1 M16C2167_20_s2_e1835_1_rf1_c1_n0| Kng5 variant HMW kininogen-I M16C2167_24_s2_e1712_1_rf2_c1_n0| Kng6 variant novel kininogen 2 M16C2166_1_s191_e1499_1_rf0_c1_n0| Kng2 variant ENSMUSG00000060459|ENSMUST00000100046|ENSMUSP kininogen 2 isoform 00000097623_s2_e1934_1_rf0_c1_n0| Kng2 2 ENSMUSG00000022875|ENSMUST00000039492|ENSMUSP kininogen 2 isoform 00000040485_s2_e1298_1_rf0_c1_n0| Kng2 2 ENSMUSG00000046834|ENSMUST00000023790|ENSMUSP 00000023790_s2_e1913_1_rf0_c1_n0| Krt1 1 ENSMUSG00000064201|ENSMUST00000023712|ENSMUSP novel Keratin 2 00000023712_s2_e2123_1_rf0_c1_n0| Krt2 variant Keratin, type II M15C7933_1_s260_e1268_1_rf2_c1_n0| Krt80 cytoskeletal 80 ENSMUSG00000031391|ENSMUST00000066605|ENSMUSP 00000068185_s2_e3782_1_rf0_c1_n0| L1cam molecule lysosomal membrane ENSMUSG00000016534|ENSMUST00000016678|ENSMUSP glycoprotein 2, 00000016678_s2_e1247_1_rf0_c1_n0| Lamp2 isoform CRA_a ENSMUSG00000026822|ENSMUST00000050785|ENSMUSP 00000053962_s2_e602_1_rf0_c1_n0| Lcn2 lipocalin 2 ENSMUSG00000021798|ENSMUST00000022327|ENSMUSP LIM domain 00000022327_s2_e2171_1_rf0_c1_n0| Ldb3 binding 3 isoform d lactate ENSMUSG00000031958|ENSMUST00000070004|ENSMUSP dehydrogenase D, 00000068086_s2_e1454_1_rf0_c1_n0| Ldhd isoform CRA_a low density ENSMUSG00000032193|ENSMUST00000034713|ENSMUSP lipoprotein receptor, 00000034713_s2_e2588_1_rf0_c1_n0| Ldlr isoform CRA_b , galactose ENSMUSG00000050335|ENSMUST00000022388|ENSMUSP binding, soluble 3, 00000022388_s2_e794_1_rf0_c1_n0| Lgals3 isoform CRA_c lectin, galactose ENSMUSG00000057554|ENSMUST00000064217|ENSMUSP binding, soluble 8, 00000066355_s2_e992_1_rf0_c1_n0| Lgals8 isoform CRA_b leukemia inhibitory factor receptor, M15C282_3_s404_e2573_1_rf1_c1_n0| Lifr isoform CRA_b LIM and senescent cell antigen-like ENSMUSG00000019920|ENSMUST00000020077|ENSMUSP domains 1 isoform 00000020077_s2_e1190_1_rf0_c1_n0| Lims1 B ENSMUSG00000028063|ENSMUST00000029699|ENSMUSP 00000029699_s2_e1997_1_rf0_c1_n0| Lmna A isoform C ENSMUSG00000032334|ENSMUST00000061799|ENSMUSP lysyl oxidase-like 1, 00000057406_s2_e1823_1_rf0_c1_n0| Loxl1 isoform CRA_a limbic system- ENSMUSG00000061080|ENSMUST00000078873|ENSMUSP associated 00000077913_s2_e1025_1_rf0_c1_n0| Lsamp ENSMUSG00000018819|ENSMUST00000018963|ENSMUSP lymphocyte specific 00000018963_s2_e998_1_rf0_c1_n0| Lsp1 1, isoform CRA_c latent transforming growth factor beta ENSMUSG00000001870|ENSMUST00000001927|ENSMUSP binding protein 1 00000001927_s2_e5138_1_rf0_c1_n0| Ltbp1 isoform LTBP-1S lymphocyte antigen ENSMUSG00000022587|ENSMUST00000023251|ENSMUSP 6 complex, locus E, 00000023251_s2_e410_1_rf0_c1_n0| Ly6e isoform CRA_a mannan-binding lectin serine ENSMUSG00000022887|ENSMUST00000023605|ENSMUSP peptidase 1, isoform 00000023605_s2_e2114_1_rf0_c1_n0| Masp1 CRA_c mannan-binding lectin serine ENSMUSG00000022887|ENSMUST00000089883|ENSMUSP peptidase 1, isoform 00000087327_s2_e2201_1_rf0_c1_n0| Masp1 CRA_b methionine ENSMUSG00000042032|ENSMUST00000040167|ENSMUSP adenosyltransferase 00000048222_s2_e1004_1_rf0_c1_n0| Mat2b II, beta novel minichromosome maintenance complex component M10C3394_4_s2_e233_1_rf2_c1_n0| Mcm9 9 variant novel malate dehydrogenase 1, M11C1527_1_s647_e782_1_rf0_c1_n0| Mdh1 NAD variant malate dehydrogenase 1, ENSMUSG00000020321|ENSMUST00000020570|ENSMUSP NAD (soluble), 00000020570_s2_e1001_1_rf0_c1_n0| Mdh1 isoform CRA_c ENSMUSG00000066366|ENSMUST00000074051|ENSMUSP 00000073695_s2_e1241_1_rf0_c1_n0| MGI:891966 Serpina1c ENSMUSG00000031402|ENSMUST00000033775|ENSMUSP membrane protein, 00000033775_s2_e1400_1_rf0_c1_n0| Mpp1 palmitoylated mCG132196, M6C9550_1_s2_e4691_1_rf1_c1_n0| Mug1 isoform CRA_b M6C9552_7_s68_e4565_1_rf0_c1_n0| Mug2 murinoglobulin 2 M6C9555_1_s2_e3725_1_rf0_c1_n0| Mug2 mCG142686 M6C9559_1_s32_e4454_1_rf0_c1_n0| Mug2 mCG132221 novel member of the major urinary protein (Mup) gene M4C3917_64_s14_e509_1_rf1_c1_n0| Mup family novel member of ENSMUSG00000073839|ENSMUST00000098047|ENSMUSP the major urinary 00000095655_s2_e542_1_rf0_c1_n0| Mup protein (Mup) gene family

novel member of the major urinary protein (Mup) gene M4C3917_29_s11_e608_1_rf2_c1_n0| Mup family novel member of the major urinary ENSMUSG00000073832|ENSMUST00000095051|ENSMUSP protein (Mup) gene 00000092661_s2_e542_1_rf0_c1_n0| Mup family Major urinary protein 1 (Novel member of the major urinary ENSMUSG00000073842|ENSMUST00000079697|ENSMUSP protein (Mup) gene 00000078636_s2_e542_1_rf0_c1_n0| Mup1 family). novel member of the major urinary protein (Mup) gene M4C3970_1_s2_e392_1_rf0_c1_n0| Mup5 family , heavy polypeptide 8, ENSMUSG00000055775|ENSMUST00000019625|ENSMUSP , 00000019625_s2_e5813_1_rf0_c1_n0| Myh8 perinatal myosin, heavy ENSMUSG00000022443|ENSMUST00000016771|ENSMUSP polypeptide 9, non- 00000016771_s2_e5882_1_rf0_c1_n0| Myh9 muscle isoform 1 myosin, light ENSMUSG00000022836|ENSMUST00000023538|ENSMUSP polypeptide kinase, 00000023538_s2_e5828_1_rf0_c1_n0| Mylk isoform CRA_b neural 1 isoform M9C3793_1_s773_e3248_1_rf0_c1_n0| Ncam1 3 neural cell adhesion ENSMUSG00000022762|ENSMUST00000037785|ENSMUSP molecule 2 isoform 00000049390_s2_e2129_1_rf0_c1_n0| Ncam2 b novel similar to nuclear factor, ENSMUSG00000021420|ENSMUST00000021857|ENSMUSP interleukin 3 00000021857_s1022_e1178_1_rf1_c1_n0| Nfil3 regulated variant ENSMUSG00000037362|ENSMUST00000100664|ENSMUSP nephroblastoma 00000098229_s2_e1064_1_rf0_c1_n0| Nov overexpressed gene PREDICTED: similar to nephronectin ENSMUSG00000040998|ENSMUST00000042729|ENSMUSP isoform 1 [Macaca 00000040071_s2_e1736_1_rf0_c1_n0| Npnt mulatta] ENSMUSG00000032336|ENSMUST00000034887|ENSMUSP neuroplastin, 00000034887_s2_e845_1_rf0_c1_n0| Nptn isoform CRA_a neuronal pentraxin 1.3 kb variant; ENSMUSG00000022421|ENSMUST00000023057|ENSMUSP neuronal pentraxin 00000023057_s2_e1481_1_rf0_c1_n0| Nptxr receptor ENSMUSG00000027455|ENSMUST00000028949|ENSMUSP NSFL1 (p97) 00000028949_s2_e1118_1_rf0_c1_n0| Nsfl1c (p47) ENSMUSG00000030824|ENSMUST00000033096|ENSMUSP nucleobindin 1, 00000033096_s2_e1379_1_rf0_c1_n0| Nucb1 isoform CRA_a ENSMUSG00000038521|ENSMUST00000068797|ENSMUSP mCG134312, 00000066999_s2_e2066_1_rf0_c1_n0| NULL isoform CRA_a PREDICTED: similar to MHC ENSMUSG00000060550|ENSMUST00000071951|ENSMUSP class I antigen 00000071843_s2_e1004_1_rf0_c1_n0| NULL isoform 7 PREDICTED: ENSMUSG00000024431|ENSMUST00000025300|ENSMUSP hypothetical protein 00000025300_s104_e344_1_rf1_c1_n0| NULL [Mus musculus] mCG120448, M4C10653_1_s2_e11219_1_rf2_c1_n0| NULL isoform CRA_a ENSMUSG00000054328|ENSMUST00000003582|ENSMUSP 00000003582_s2_e1739_1_rf0_c1_n0| NULL Igh-6 protein ENSMUSG00000057037|ENSMUST00000027612|ENSMUSP complement factor 00000027612_s2_e2426_1_rf0_c1_n0| NULL H-related ENSMUSG00000061260|ENSMUST00000096141|ENSMUSP immunoglobulin 00000093855_s2_e710_1_rf0_c1_n0| NULL kappa light chain ENSMUSG00000061944|ENSMUST00000066434|ENSMUSP immunoglobulin 00000064904_s2_e704_1_rf0_c1_n0| NULL lambda chain immunoglobulin ENSMUSG00000061944|ENSMUST00000074329|ENSMUSP lambda chain C3 00000073937_s2_e314_1_rf0_c1_n0| NULL region PREDICTED: M9C346_1_s2822_e2930_1_rf0_c1_n0| NULL hypothetical protein novel PCTAIRE- motif protein kinase 2, isoform CRA_b M9C7735_1_s299_e431_1_rf2_c1_n0| NULL variant M5C5274_1_s2_e95_1_rf0_c1_n0| NULL NULL Mouse Gene M5C6289_2_s6809_e6878_1_rf0_c1_n0| NULL AK046278 M6C5115_1_s2_e287_1_rf0_c1_n0| NULL mCG141619 immunoglobulin light chain variable M6C5153_1_s2_e305_1_rf0_c1_n0| NULL region Parts of , mostly variable M6C5180_1_s2_e299_1_rf0_c1_n0| NULL regions M5C7372_1_s1985_e2147_1_rf2_c1_n0| NULL NULL M6C10494_1_s1445_e1496_1_rf1_c1_n0| NULL mRNA AK142517 M6C11974_1_s263_e389_1_rf2_c1_n0| NULL mCG148006 mCG132196, M6C9562_1_s35_e890_1_rf2_c1_n0| NULL isoform CRA_a PREDICTED: similar to Glyceraldehyde-3- phosphate M7C3380_1_s800_e977_1_rf1_c1_n0| NULL dehydrogenase M10C5037_1_s758_e818_1_rf0_c1_n0| NULL NULL M11C6912_1_s2_e128_1_rf0_c1_n0| NULL B predicted gene, M12C3992_1_s2_e1088_1_rf1_c1_n0| NULL EG622339 M14C7677_1_s356_e431_1_rf1_c1_n0| NULL NULL M13C6688_1_s65_e668_1_rf1_c1_n0| NULL laminin receptor PREDICTED: similar to M12C8405_1_s2_e2699_1_rf1_c1_n0| NULL KIAA2019 protein immunoglobulin lambda light chain variable region M16C1747_1_s2_e293_1_rf0_c1_n0| NULL precursor M18C1535_1_s212_e437_1_rf1_c1_n0| NULL NULL M17C5283_5_s2_e98_1_rf1_c1_n0| NULL NULL M16C7183_12_s785_e959_1_rf2_c1_n0| NULL NULL M1C10834_9_s770_e824_1_rf2_c1_n0| NULL NULL M1C2399_2_s212_e398_1_rf0_c1_n0| NULL mRNA BC079869 PREDICTED: similar to Glyceraldehyde-3- M1C4544_1_s2_e68_1_rf0_c1_n0| NULL phosphate dehydrogenase PREDICTED: similar to Glyceraldehyde-3- phosphate M3C2490_1_s2_e806_1_rf1_c1_n0| NULL dehydrogenase PREDICTED: similar to Glyceraldehyde-3- phosphate M1C649_1_s2_e1067_1_rf1_c1_n0| NULL dehydrogenase novel ADP- ribosylation factor- M3C7006_3_s2153_e2216_1_rf1_c1_n0| NULL like 16 variant PREDICTED: similar to Predicted gene, ENSMUSG00000073832|ENSMUST00000074018|ENSMUSP OTTMUSG000000 00000073667_s2_e545_1_rf0_c1_n0| OTTMUSG00000007485 07485 and casein kinase ENSMUSG00000016664|ENSMUST00000056177|ENSMUSP substrate in 00000058320_s2_e1460_1_rf0_c1_n0| Pacsin2 2, isoform CRA_a Regenerating islet- ENSMUSG00000071356|ENSMUST00000095790|ENSMUSP derived protein 3 00000093466_s2_e500_1_rf0_c1_n0| Pap1 beta proprotein convertase ENSMUSG00000039278|ENSMUST00000041096|ENSMUSP subtilisin/kexin type 00000040342_s2_e776_1_rf0_c1_n0| Pcsk1n 1 inhibitor proprotein convertase ENSMUSG00000024713|ENSMUST00000025618|ENSMUSP subtilisin/kexin type 00000025618_s2_e5633_1_rf0_c1_n0| Pcsk5 5 platelet derived growth factor, ENSMUSG00000025856|ENSMUST00000046901|ENSMUSP alpha, isoform 00000038870_s2_e590_1_rf0_c1_n0| Pdgfa CRA_a PDZ and LIM ENSMUSG00000028273|ENSMUST00000029941|ENSMUSP domain 5 isoform 00000029941_s2_e1775_1_rf0_c1_n0| Pdlim5 ENH3 plasma glutamate ENSMUSG00000039007|ENSMUST00000042167|ENSMUSP carboxypeptidase, 00000039046_s2_e1412_1_rf0_c1_n0| Pgcp isoform CRA_a ENSMUSG00000028961|ENSMUST00000084124|ENSMUSP mCG141692, 00000081141_s2_e1451_1_rf0_c1_n0| Pgd isoform CRA_c peptidoglycan recognition protein M17C3621_1_s41_e485_1_rf0_c1_n0| Pglyrp2 2, isoform CRA_a novel peptidase M17C3134_2_s143_e1232_1_rf1_c1_n0| Pi16 inhibitor 16 variant phosphoinositide-3- ENSMUSG00000034614|ENSMUST00000045153|ENSMUSP kinase interacting 00000036921_s2_e794_1_rf0_c1_n0| Pik3ip1 protein 1 cAMP-dependent ENSMUSG00000035268|ENSMUST00000064703|ENSMUSP protein kinase 00000068344_s2_e230_1_rf0_c1_n0| Pkig inhibitor gamma novel pyruvate M9C5102_28_s74_e1844_1_rf0_c1_n0| Pkm2 kinase M1 variant M2-type pyruvate M9C5102_135_s74_e1916_1_rf0_c1_n0| Pkm2 kinase phospholipase A2, group VII (platelet- activating factor acetylhydrolase, ENSMUSG00000023913|ENSMUST00000024706|ENSMUSP plasma), isoform 00000024706_s2_e1322_1_rf0_c1_n0| Pla2g7 CRA_b M17C840_5_s2_e287_1_rf2_c1_n0| Plg plasminogen, isoform CRA_l periostin, osteoblast ENSMUSG00000027750|ENSMUST00000073012|ENSMUSP specific factor, 00000072773_s2_e2435_1_rf0_c1_n0| Postn isoform CRA_b novel peptidylprolyl -like 2 M16C1328_76_s1403_e1610_1_rf0_c1_n0| Ppil2 variant novel peroxiredoxin M1C7134_1_s314_e689_1_rf2_c1_n0| Prdx2 2 variant ENSMUSG00000025289|ENSMUST00000026328|ENSMUSP peroxiredoxin 4, 00000026328_s2_e824_1_rf0_c1_n0| Prdx4 isoform CRA_a ENSMUSG00000024953|ENSMUST00000025904|ENSMUSP peroxiredoxin 5, 00000025904_s2_e632_1_rf0_c1_n0| Prdx5 isoform CRA_b ENSMUSG00000026701|ENSMUST00000071718|ENSMUSP 00000071636_s2_e674_1_rf0_c1_n0| Prdx6 peroxiredoxin 6 novel proteoglycan M1C9704_2_s2_e1295_1_rf1_c1_n0| Prg4 4 variant ENSMUSG00000075543|ENSMUST00000100433|ENSMUSP parahox cluster 00000098000_s2_e536_1_rf0_c1_n0| Prhoxnb neighbor ENSMUSG00000027338|ENSMUST00000091288|ENSMUSP 00000088833_s2_e764_1_rf0_c1_n0| Prnp protein protein C receptor, ENSMUSG00000027611|ENSMUST00000029140|ENSMUSP endothelial, isoform 00000029140_s2_e728_1_rf0_c1_n0| Procr CRA_b beta 3 M11C10497_1_s2_e704_1_rf0_c1_n0| Psmb3 subunit proteasome (prosome, macropain) 26S ENSMUSG00000002102|ENSMUST00000002171|ENSMUSP subunit, ATPase 3, 00000002171_s2_e1355_1_rf0_c1_n0| Psmc3 isoform CRA_b (prosome, macropain) 26S ENSMUSG00000020708|ENSMUST00000021049|ENSMUSP subunit, ATPase 5, 00000021049_s2_e1220_1_rf0_c1_n0| Psmc5 isoform CRA_c proteasome (prosome, macropain) 26S ENSMUSG00000029440|ENSMUST00000060664|ENSMUSP subunit, non- 00000053348_s2_e749_1_rf0_c1_n0| Psmd9 ATPase,9 protein tyrosine phosphatase, ENSMUSG00000020154|ENSMUST00000020363|ENSMUSP receptor type, B, 00000020363_s2_e2171_1_rf0_c1_n0| Ptprb isoform CRA_b pregnancy zone protein, isoform M6C10357_3_s2_e4541_1_rf2_c1_n0| Pzp CRA_a quiescin Q6 sulfhydryl oxidase 1 M1C10236_3_s572_e2303_1_rf1_c1_n0| Qsox1 isoform b ENSMUSG00000071356|ENSMUST00000101272|ENSMUSP regenerating islet- 00000098829_s2_e527_1_rf0_c1_n0| Reg3a derived 3 alpha novel roundabout M16C5680_2_s3482_e3536_1_rf0_c1_n0| Robo1 homolog 1 variant ribulose-5- phosphate-3- ENSMUSG00000026005|ENSMUST00000027157|ENSMUSP epimerase, isoform 00000027157_s2_e686_1_rf0_c1_n0| Rpe CRA_b ENSMUSG00000022601|ENSMUST00000023269|ENSMUSP ribosomal protein 00000023269_s2_e473_1_rf0_c1_n0| Rpl24 L24 Ribosomal protein M10C964_1_s125_e335_1_rf2_c1_n0| Rpl7a L7a variant ribosomal protein M16C1930_1_s2_e536_1_rf2_c1_n0| Rps10 S10 M3C6068_1_s2_e536_1_rf1_c1_n0| Rps10 novel ribosomal protein S10 variant scaffold attachment ENSMUSG00000042625|ENSMUST00000049279|ENSMUSP factor B2, isoform 00000036869_s2_e2975_1_rf0_c1_n0| Safb2 CRA_b SAM domain and ENSMUSG00000027639|ENSMUST00000057725|ENSMUSP HD domain, 1, 00000059717_s2_e1883_1_rf0_c1_n0| Samhd1 isoform CRA_b ENSMUSG00000046056|ENSMUST00000080518|ENSMUSP suprabasin isoform 00000079362_s2_e2048_1_rf0_c1_n0| Sbsn 1 ENSMUSG00000050711|ENSMUST00000049972|ENSMUSP secretogranin 2, 00000062556_s2_e1853_1_rf0_c1_n0| Scg2 isoform CRA_a ENSMUSG00000025647|ENSMUST00000026737|ENSMUSP shisa homolog 5 00000026737_s2_e707_1_rf0_c1_n0| Scotin isoform 1 ENSMUSG00000025165|ENSMUST00000026162|ENSMUSP secreted and 00000026162_s2_e578_1_rf0_c1_n0| Sectm1a transmembrane 1A ENSMUSG00000026581|ENSMUST00000027871|ENSMUSP L- isoform 00000027871_s2_e1118_1_rf0_c1_n0| Sell v2 novel selenoprotein M15C8_14_s44_e164_1_rf1_c1_n0| Sepp1 P, plasma, 1 novel serine (or cysteine) peptidase inhibitor, clade A M12C7321_8_s2_e554_1_rf1_c1_n0| Serpina1 variant novel alpha-1- M12C7321_47_s77_e791_1_rf2_c1_n0| Serpina1 antitrypsin variant serine (or cysteine) proteinase inhibitor, M12C7321_36_s77_e1328_1_rf2_c1_n0| Serpina1a clade A, member 1a ENSMUSG00000066366|ENSMUST00000085056|ENSMUSP 00000082132_s2_e1241_1_rf0_c1_n0| Serpina1a alpha-1-antitrypsin M12C7328_1_s2_e110_1_rf0_c1_n0| Serpina1c Serpina1c protein Chain A, Serpina3n, A Murine Orthologue Of Human M12C7375_1_s488_e1385_1_rf0_c1_n0| Serpina3 Antichymotrypsin M12C7377_17_s2_e1274_1_rf0_c1_n0| Serpina3f Serpina3f protein serine (or cysteine) proteinase inhibitor, ENSMUSG00000058207|ENSMUST00000043058|ENSMUSP clade A, member 00000042095_s2_e1256_1_rf0_c1_n0| Serpina3k 3K serine (or cysteine) proteinase inhibitor, ENSMUSG00000058207|ENSMUST00000055089|ENSMUSP clade A, member 00000060889_s2_e1256_1_rf0_c1_n0| Serpina3m 3M serine (or cysteine) peptidase inhibitor, clade A, member M12C7376_1_s488_e1226_1_rf1_c1_n0| Serpina3n 3N, isoform CRA_b serine (or cysteine) proteinase inhibitor, clade C ENSMUSG00000026715|ENSMUST00000028046|ENSMUSP (), 00000028046_s2_e1397_1_rf0_c1_n0| Serpinc1 member 1 novel serpinc1 M1C10715_5_s671_e983_1_rf0_c1_n0| Serpinc1 varaiant serine (or cysteine) peptidase inhibitor, ENSMUSG00000000753|ENSMUST00000000769|ENSMUSP clade F, member 1, 00000000769_s2_e1253_1_rf0_c1_n0| Serpinf1 isoform CRA_b novel serine (or cysteine) proteinase inhibitor, clade F, M11C7153_7_s605_e1532_1_rf2_c1_n0| Serpinf2 member 2 variant ENSMUSG00000025982|ENSMUST00000027127|ENSMUSP splicing factor 3b, 00000027127_s2_e3923_1_rf0_c1_n0| Sf3b1 subunit 1 SH3-domain GRB2- like (endophilin) ENSMUSG00000028524|ENSMUST00000080728|ENSMUSP interacting protein 00000079553_s2_e2426_1_rf0_c1_n0| Sgip1 1, isoform CRA_a N-sulfoglucosamine sulfohydrolase ENSMUSG00000005043|ENSMUST00000005173|ENSMUSP (sulfamidase), 00000005173_s2_e1508_1_rf0_c1_n0| Sgsh isoform CRA_b SH3 domain binding glutamic acid-rich protein like 2, isoform M9C7583_2_s158_e491_1_rf0_c1_n0| Sh3bgrl2 CRA_b SH3-binding domain glutamic acid-rich protein like, isoform MXC4909_1_s410_e1124_1_rf0_c1_n0| SH3BGRL3 CRA_b ENSMUSG00000001942|ENSMUST00000002007|ENSMUSP sialic acid 00000002007_s2_e1625_1_rf0_c1_n0| Siae acetylesterase novel solute carrier family 19 (sodium/hydrogen) M1C5543_4_s254_e473_1_rf1_c1_n0| Slc19a1 variant solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23, M17C6471_1_s68_e1592_1_rf1_c1_n0| Slc25a23 isoform CRA_b secreted ENSMUSG00000029304|ENSMUST00000086833|ENSMUSP phosphoprotein 1, 00000084043_s2_e887_1_rf0_c1_n0| Spp1 isoform CRA_c novel secreted phosphoprotein 2 M1C6307_3_s2_e581_1_rf1_c1_n0| Spp2 variant secreted phosphoprotein 2, M1C6308_1_s2_e134_1_rf1_c1_n0| Spp2 isoform CRA_b ENSMUSG00000003161|ENSMUST00000003245|ENSMUSP 00000003245_s2_e596_1_rf0_c1_n0| Sri sorcin isoform 2 SMT3 suppressor of mif two 3 homolog ENSMUSG00000020265|ENSMUST00000020501|ENSMUSP 3 (yeast), isoform 00000020501_s2_e332_1_rf0_c1_n0| Sumo3 CRA_c sushi domain M9C10588_1_s338_e2264_1_rf0_c1_n0| Susd5 containing 5 ENSMUSG00000040132|ENSMUST00000044953|ENSMUSP seminal vesicle 00000042389_s2_e1127_1_rf0_c1_n0| Svs2 secretory protein 2 M1C12034_2_s455_e1139_1_rf0_c1_n0| Tagln2 transgelin 2 ENSMUSG00000027082|ENSMUST00000090732|ENSMUSP pathway inhibitor, 00000088235_s2_e707_1_rf0_c1_n0| Tfpi isoform CRA_c of inner mitochondrial membrane 50 ENSMUSG00000003438|ENSMUST00000081946|ENSMUSP homolog (yeast), 00000080614_s2_e1061_1_rf0_c1_n0| Timm50 isoform CRA_a ENSMUSG00000028364|ENSMUST00000030056|ENSMUSP tenascin C, isoform 00000030056_s2_e6059_1_rf0_c1_n0| Tnc CRA_a TNF receptor ENSMUSG00000030341|ENSMUST00000032491|ENSMUSP superfamily, 00000032491_s2_e1364_1_rf0_c1_n0| Tnfrsf1a member 1A 1, M9C6099_127_s254_e1022_1_rf1_c1_n0| Tpm1 alpha, isoform CRA_b tropomyosin 1, alpha, isoform M9C6099_61_s221_e1013_1_rf2_c1_n0| Tpm1 CRA_d , M3C5285_1_s62_e938_1_rf2_c1_n0| Tpm3 gamma tropomyosin 1, ENSMUSG00000027940|ENSMUST00000029549|ENSMUSP alpha, isoform 00000029549_s2_e746_1_rf0_c1_n0| Tpm3 CRA_g M4C2515_16_s182_e1088_1_rf0_c1_n0| Tpmb tropomyosin 2 beta novel M13C7050_1_s167_e287_1_rf1_c1_n0| Tuba1a cofactor a variant similar to ubiquitin A-52 residue ENSMUSG00000008348|ENSMUST00000008492|ENSMUSP ribosomal protein 00000008492_s2_e917_1_rf0_c1_n0| Uba52 isoform 1 vascular cell adhesion molecule M3C8092_1_s2_e344_1_rf2_c1_n0| Vcam1 1, isoform CRA_b ENSMUSG00000021823|ENSMUST00000022369|ENSMUSP , isoform 00000022369_s2_e3200_1_rf0_c1_n0| Vcl CRA_b novel vitamin d binding protein M5C6352_5_s104_e1163_1_rf2_c1_n0| Vdbp variant novel vitamin d binding protein M5C6352_7_s782_e884_1_rf1_c1_n0| Vdbp variant novel vitamin D- binding protein M8C3753_1_s122_e296_1_rf1_c1_n0| Vdbp variant ENSMUSG00000001930|ENSMUST00000001995|ENSMUSP von Willebrand 00000001995_s2_e8441_1_rf0_c1_n0| Vwf factor xanthine ENSMUSG00000024066|ENSMUST00000024866|ENSMUSP dehydrogenase, 00000024866_s2_e4007_1_rf0_c1_n0| Xdh isoform CRA_c ENSMUSG00000018554|ENSMUST00000018698|ENSMUSP Y-box protein 00000018698_s2_e1079_1_rf0_c1_n0| Ybx2 MSY2 isoform a ENSMUSG00000029860|ENSMUST00000031890|ENSMUSP zyxin, isoform 00000031890_s2_e1601_1_rf0_c1_n0| Zyx CRA_b

Table 2: 92 novel isoforms identified by unique peptides. The parent gene name is the gene to which the peptides aligned with certain similarity by blat and blastp analysis. Gene Symbol is the gene symbol for the parent gene. The nomenclature of the splice variant identifier is as follows: for example, in M5C6439_17_s2_e317_1_rf1_c1_n0|, M5C6439_17 (M5C6439.17) is the ECGene database identifier, s2 is start site, e317 is end site, 1 is positive strand, rf0 is the first reading frame (rf1 is second reading frame and rf2 is third reading frame) , c1 is the number of times this particular sequence was observed in the database, n0 is the number of ‘n’s substituted in the sequence.

gene protein Protein identifier symbol description unique peptide hypothetical protein A630042 LOC106894 M18C4209_1_s2543_e2729_1_rf1_c1_n0| L21Rik isoform 2 variant VSRALVSNSGGR MXC1985_1_s2_e593_1_rf1_c1_n0| Actb beta actin variant YPIEHCIVTNWDDMEK variant of alpha M5C6460_1_s86_e1988_1_rf0_c1_n0| Afp fetoprotein DVCFQEEGPQLITK alpha-2-HS- glycoprotein RPFGVVYEMEVDTLETTCHALDP M16C2151_19_s71_e740_1_rf2_c1_n0| Ahsg variant TPLANLMHNLGG alpha-2-HS- glycoprotein SWWGRSFSGLQVIPNTADPPASV M16C2151_59_s749_e1013_1_rf0_c1_n0| Ahsg variant VVGPVVVPR alpha-2-HS- glycoprotein GAANPLHKRPFGVVYEMEVDTL M16C2151_75_s77_e959_1_rf1_c1_n0| Ahsg variant ETTCHAL alpha-2-HS- glycoprotein M16C2153_1_s11_e218_1_rf1_c1_n0| Ahsg variant CAFSPVASVESASGETLHSPK M5C6439_17_s2_e317_1_rf1_c1_n0| Alb albumin variant EYSRRHPDICTLPEKEKQI aldolase 3 C M11C7819_20_s1118_e1505_1_rf0_c1_n0| Aldoc variant NHPEEIAMATVTALR apolipoprotein a1 M9C3524_2_s2_e758_1_rf0_c1_n0| Apoa1 variant DYVSQFESSSLGQQLNLNLLEK apolipoprotein A- DFANVYVDAVKDSGRDLGSTVS M9C3524_4_s2_e758_1_rf2_c1_n0| Apoa1 I variant QLQER apolipoprotein A- M9C3524_5_s2_e710_1_rf0_c1_n0| Apoa1 I variant DFANVYVDAVKDSPLTR apolipoprotein A- M9C3524_8_s11_e899_1_rf2_c1_n0| Apoa1 I variant VAPLGAELQESR apolipoprotein a1 M9C3525_1_s296_e563_1_rf1_c1_n0| Apoa1 variant DYVSQFESSSLGQQLK apolipoprotein a4 LGDASTYADGDAVDLQDQINTQ M9C3532_2_s281_e1313_1_rf0_c1_n0| Apoa4 variant TQEMK apolipoprotein c3 QLATPGAEEVEGSLLLGSVQGYM M9C3528_4_s23_e284_1_rf1_c1_n0| Apoc3 variant EQASK apolipoprotein e GAGGTAGSSGGGDTGQAGQRGA M7C1596_30_s362_e638_1_rf2_c1_n0| Apoe variant GWFEPIV complement c3 M17C6514_5_s2_e3413_1_rf2_c1_n0| C3 variant VFSLAANLIAIDSHVLWPLE capping protein (actin filament) muscle Z-line M6C861_14_s2_e158_1_rf1_c1_n0| Capza2 variant CAAAWAAGPLPWRGR ENSMUSG00000058952|ENSMUST000000 98620|ENSMUSP00000096220_s2_e1805_1 cpmplement _rf0_c1_n0| Cf1 factor i variant KPATVSMTGDQSDELCCK complement component factor QGYVTNTGEISGSITCLQNGWSP M1C9426_3_s26_e914_1_rf1_c1_n0| Cfh H variant QPSCIMK complement component factor M1C9441_5_s110_e3896_1_rf0_c1_n0| Cfh H variant AGQVASCAPPLEILNGEINGAK collagen, type 1, M11C9935_216_s128_e4526_1_rf0_c1_n0| Col1a1 alpha 1 variant RAKIPEVSCIHNGLR ceruloplasmin M3C681_1_s275_e461_1_rf0_c1_n0| Cp variant RQLMLALSLGPVIWAEVGDTIK cytochrome c M6C11984_1_s2906_e3146_1_rf0_c1_n0| Cycs variant ASQAAGFSYTDANK DEAD (Asp-Glu- Ala-Asp) box polypeptide 6 M9C3191_1_s380_e587_1_rf2_c1_n0| Ddx6 variant AAESAQPGGGDIGGAGTAGAGR extra cellular matrix protein 1 M3C6105_9_s107_e1466_1_rf0_c1_n0| Ecm1 variant QCCELPYPEQACCGEEEK M8C7190_1_s53_e1790_1_rf2_c1_n0| Es1 esterase 1 variant AISESSVVLGTNLR coagulation M13C4204_1_s1163_e1826_1_rf2_c1_n0| F12 factor 12 variant GSLPAESATPEELTVVLGQDR F-box and leucine-rich repeat M15C1226_1_s899_e1028_1_rf2_c1_n0| Fbxl7 protein 7 variant QYDNIAIYKIDELK CCMARYCPSPIDLSNPSALEAATE M16C2158_6_s209_e1046_1_rf1_c1_n0| Fetub fetuin beta variant SLAK fibrinogen alpha M3C4196_1_s74_e1811_1_rf1_c1_n0| Fga variant VLLRFSSSSPHEPSLNADTM fibrinogen, alpha RMELERPGKDGGSRGDSPGDSRG M3C4202_1_s2_e272_1_rf2_c1_n0| Fga variant DSRGDGKE fibronectin 1 M1C4590_702_s41_e6875_1_rf0_c1_n0| Fn1 variant HPLKMLRGPGPGRLLLLAVLCL fibronectin 1 SPGVQYNITIYAVEENQESTPVFI M1C4590_768_s41_e6851_1_rf0_c1_n0| Fn1 variant QQETTGTPR glyceraldehyde-3- phosphate dehydrogenase M3C108_1_s395_e980_1_rf1_c1_n0| Gapdh variant IVSNASCTTNCLAPIAK glyceraldehyde-3- phsphate dehydrogenase M5C4343_1_s404_e584_1_rf0_c1_n0| Gapdh variant LISWYDSECGYSNR Glyceraldehyde- 3-phosphate dehydrogenase M15C4263_1_s20_e1016_1_rf1_c1_n0| Gapdh variant MGNLSSRGSPSPSSRSETPLT Glyceraldehyde- 3-phosphate dehydrogenase M11C348_1_s1766_e2621_1_rf0_c1_n0| Gapdh variant AAASSCAVPPQNGEGRSVNG glutathione M11C4339_13_s332_e530_1_rf2_c1_n0| Gpx3 peoxidase variant YVRPGGGFVPNFQI hemoglobin alpha, adult chain 2 M11C2347_4_s263_e383_1_rf1_c1_n0| Hba-a2 variant CPVCLASHHPADFTPAVHASLDK hemoglobin alpha, adult chain 2 M11C2347_6_s17_e383_1_rf2_c1_n0| Hba-a2 variant TYFPHFDVSHGSAQSAL hemoglobin beta chain subunit M7C9167_6_s11_e539_1_rf0_c1_n0| Hbb variant PETDIMVHLTDAEK hepatocyte growth factor activator M5C2929_10_s1346_e1892_1_rf1_c1_n0| Hgfac variant RQSLPVGVEAGGRQA high mobility group protein B2 M18C3726_1_s2_e347_1_rf0_c1_n0| Hmgb2 variant MPSYAFFVQTCR hemopexin M8C8688_3_s53_e428_1_rf2_c1_n0| hpx variant LPECEAGQDDLPPR hemopexin M7C9387_1_s92_e434_1_rf1_c1_n0| Hpx variant MLPFPGISLETIDAAFSCPGSSR hemopexin M7C9387_12_s2_e515_1_rf2_c1_n0| Hpx variant LFQEEFPGIPYPPDNPKGTFLV hemopexin M7C9387_17_s194_e1220_1_rf0_c1_n0| Hpx variant HALFQEEFPGIPYPPDAAVECHR hemopexin M7C9387_19_s2_e1346_1_rf2_c1_n0| Hpx variant NPDPGLTALLSDHR hemopexin VTSSCDSTPPGISLETIDAAFSCPG M7C9387_2_s5_e392_1_rf2_c1_n0| Hpx variant SSR hemopexin M7C9387_3_s2_e728_1_rf0_c1_n0| Hpx variant CSPDPGLTALL kininogen 1 YTCSAQSGLAWQDCDFKDAEEA M16C2167_20_s2_e1835_1_rf1_c1_n0| Kng1 variant ATGECTATVGK kininogen 2 M16C2166_1_s191_e1499_1_rf0_c1_n0| Kng2 variant CQALDKTCFLL ENSMUSG00000064201|ENSMUST000000 23712|ENSMUSP00000023712_s2_e2123_1 _rf0_c1_n0| Krt2 Keratin 2 variant ESEELYHSKANYEELQVTAVK minichromosome maintenance complex component 9 M10C3394_4_s2_e233_1_rf2_c1_n0| Mcm9 variant EGAGPLAPGGPEQASCR malate dehydrogenase 1, M11C1527_1_s647_e782_1_rf0_c1_n0| Mdh1 NAD variant NHLVEALDLSCPQR member of the ENSMUSG00000073832|ENSMUST000000 major urinary 95051|ENSMUSP00000092661_s2_e542_1_ protein (Mup) rf0_c1_n0| Mup gene family AGEYSVTYDGFNTFTIPK member of the ENSMUSG00000073839|ENSMUST000000 major urinary 98047|ENSMUSP00000095655_s2_e542_1_ protein (Mup) rf0_c1_n0| Mup gene family LFLEQIHVLEK member of the major urinary protein (Mup) M4C3917_29_s11_e608_1_rf2_c1_n0| Mup gene family AGKYSVTYDGFNTFTIPK member of the major urinary protein (Mup) TDYDNFLMAHLINEKDGETFQLM M4C3917_64_s14_e509_1_rf1_c1_n0| Mup gene family GLYDR Major urinary protein 1 ( member of the major ENSMUSG00000073842|ENSMUST000000 urinary protein 79697|ENSMUSP00000078636_s2_e542_1_ (Mup) gene rf0_c1_n0| Mup1 family). VHTVRDEECSELSMVADK member of the major urinary protein (Mup) M4C3970_1_s2_e392_1_rf0_c1_n0| Mup5 gene family DGECSEISMVADK ENSMUSG00000021420|ENSMUST000000 nuclear factor, 21857|ENSMUSP00000021857_s1022_e117 interleukin 3 8_1_rf1_c1_n0| Nfil3 regulated variant MISMTSSEQSEETW M10C5037_1_s758_e818_1_rf0_c1_n0| NULL NULL VDIRPKTQNTQGTVCK M14C7677_1_s356_e431_1_rf1_c1_n0| NULL NULL VQPLLTVDACDITTNFR M18C1535_1_s212_e437_1_rf1_c1_n0| NULL NULL DTSPRLRITSGDGLMDNKVSR M16C7183_12_s785_e959_1_rf2_c1_n0| NULL NULL RQHGQGSSYK ADP-ribosylation factor-like 16 M3C7006_3_s2153_e2216_1_rf1_c1_n0| NULL variant TGGMAQWLRAQASLQ M5C5274_1_s2_e95_1_rf0_c1_n0| NULL NULL EPCNTVAWK M17C5283_5_s2_e98_1_rf1_c1_n0| NULL NULL EDGGGSGGGGDADSR M1C10834_9_s770_e824_1_rf2_c1_n0| NULL NULL FSCGGGESIEGGQTMGS M5C7372_1_s1985_e2147_1_rf2_c1_n0| NULL NULL CSVTAAESR PCTAIRE-motif protein kinase 2, isoform CRA_b M9C7735_1_s299_e431_1_rf2_c1_n0| NULL variant CELAEQMTSLLER peptidase inhibitor 16 M17C3134_2_s143_e1232_1_rf1_c1_n0| Pi16 variant ATEAPSSRETGAENPEK pyruvate kinase M9C5102_28_s74_e1844_1_rf0_c1_n0| Pkm2 variant CLAAALIVLTESGR peptidylprolyl isomerase-like 2 M16C1328_76_s1403_e1610_1_rf0_c1_n0| Ppil2 variant WSSLRPYLVWIVR peroxiredoxin 2 KLGCEVLGVSVDSQFTHQAWINT M1C7134_1_s314_e689_1_rf2_c1_n0| Prdx2 variant PR proteoglycan 4 M1C9704_2_s2_e1295_1_rf1_c1_n0| Prg4 variant CCADYDSFCEEVK roundabout M16C5680_2_s3482_e3536_1_rf0_c1_n0| Robo1 homolog 1 variant QISCVEGLLQDKCS ribosomal protein M3C6068_1_s2_e536_1_rf1_c1_n0| Rps10 S10 variant TEAGAGSATEFQFR selenoprotein P, M15C8_14_s44_e164_1_rf1_c1_n0| Sepp1 plasma, 1 TPEWYIGDQNPMLNSEGK alpha-1- M12C7321_47_s77_e791_1_rf2_c1_n0| Serpina1 antitrypsin variant KPFDPENTEGK serine (or cysteine) peptidase inhibitor, clade A M12C7321_8_s2_e554_1_rf1_c1_n0| Serpina1 variant QASPASHEIATNLGDFAISLYR M1C10715_5_s671_e983_1_rf0_c1_n0| Serpinc1 serpinc1 varaiant EGTLQDMGLIDLFSPEK serine (or cysteine) proteinase inhibitor, clade F, M11C7153_7_s605_e1532_1_rf2_c1_n0| Serpinf2 member 2 variant KEEDLANINQWVK solute carrier family 19 (sodium/hydrogen) M1C5543_4_s254_e473_1_rf1_c1_n0| Slc19a1 variant ILRLPIHTCPLLGELDYR secreted phosphoprotein 2 HCGLCVCCLGFPVYDYDPSSLQE M1C6307_3_s2_e581_1_rf1_c1_n0| Spp2 variant ALSASVAK tubulin cofactor a M13C7050_1_s167_e287_1_rf1_c1_n0| Tuba1a variant CQASSFTESSTTR vitamin d binding EVSHQPQEFPTYVEPTNDEICEAF M5C6352_5_s104_e1163_1_rf2_c1_n0| Vdbp protein variant R vitamin d binding QKDFASKCCSINSPPLYCSSQIDA M5C6352_7_s782_e884_1_rf1_c1_n0| Vdbp protein variant EMIDTLQS vitamin D-binding M8C3753_1_s122_e296_1_rf1_c1_n0| Vdbp protein variant FCYQWQFSENTFTEYK

Table 3: Eight novel identifications where the peptide sequences were not found in any known mouse proteins but the complete protein sequences aligned perfectly with mouse genomic regions

Identifier Mouse genome M1C10834_9_s770_e824_1_rf2_c1_n0| Mus musculus , clone RP24-377P1, complete sequence M10C5037_1_s758_e818_1_rf0_c1_n0| Mus musculus BAC clone RP24-480K24 from , complete sequence M18C1535_1_s212_e437_1_rf1_c1_n0| Mus musculus , clone RP24-559H7, complete sequence M5C5274_1_s2_e95_1_rf0_c1_n0| Mus musculus , clone RP23-318I19, complete sequence M5C7372_1_s1985_e2147_1_rf2_c1_n0| Mus musculus BAC clone RP24-292F8 from chromosome 5, complete sequence

M14C7677_1_s356_e431_1_rf1_c1_n0| Mus musculus 7 days neonate cDNA, RIKEN full- length enriched library, clone:A730094123 product unclassifiable M16C7183_12_s785_e959_1_rf2_c1_n0| Mus musculus adult male olfactory brain cDNA, RIKEN full- length enriched library, clone:6430558G07 product: domain 3, full insert sequence M17C5283_5_s2_e98_1_rf1_c1_n0| Mus musculus RNA polymerase 1-1 (Rpo1-1), mRNA

Table 4: GO terms associated with the parent of the novel splice variant proteins. Only the terms with more than one gene linked with it are shown

Gene Ontology Term parent gene symbols (the number in parentheses represents the number of splice variants identified for that gene)

Cellular Component extracellular region afp,ahsg,alb,apoe,f12,sepp1,serpina1,serpinc1,spp2,apoa1,apoa4,apoc3,c3,cp,ecm1,fetub,f ga,hgfac,hp,hpx,kng1,pi16,serpinf2,cfh,es1,fga,prg4,col1a1,gpx3,mup5,robo1 membrane robo1,slc19a1,mup1,fn1 alb, col1a1,hmgb2,cfh,gapdh,pkm2,prdx2,actb,apoe,krt2,cycs,mdh1,rps10 cycs, pkm2, aldoc, rps10, pkm2, nucleus apoa1,cfh,ddx6,ecm1,gapdh,nfil3,ppil2,cycs,hmgb2 Molecular Function protein binding actb,apoa1,c3,col1a1,cycs,fbxl7,krt2,pkm2,robo1,serpina1,serpinf2,alb,aldoc,capza2,cfh,d dx6,fn1,gapdh,hgfac,serpinc1,fga lipid binding apoc3, apoa1, apoa4, apoe actin binding capza2, vdbp metal ion binding alb. Apoa4, afp, cp, cycs,hba-a2,hpx,hbb, pkm2,hbb,prdx2,sepp1,gpx3,kng1 ATP binding actb,ddx6,mcm9 nucleotide binding alb,hmgb2,mcm9, nfil3 receptor activity robo1,c3,kng1,fga peptidase activity f12, pi16, hgfac /serine type inhibitor f12,hgfac,hp,serpinc1,serpinf2,serpina1,kng1,serpinc1,c3,mup5,serpinf2,spp2 activity inhibitor activity fetub, kng1, kng2 ,ahsg activity cp , mdh1, gpx3, prdx2,fn1,gapdh antioxidant /peroxidase activity alb, apoe , prdx2, gpx2 factor activity hmgb2,nfil3,gpx3 Biological Process transport apoe,hbaa2,mup1,slc19a1,afp,alb,apoa1,apoa4,apoc3,cp,cycs,ecm1,hbb,hpx,mup5 lipid metabolic process apoa1, apoe , apoa4, apoc3 glycolysis aldoc, mdh1, pkm2, gapdh cell adhesion col1a1, robo1, fn1 immune response c3, afp,cfh, nfil3 acute-phase response ahsg, hp, serpina1a, serpinf2, fn1 inflammatory response serpinc1,apoc3,c3,kng1 positive regulation of phagocytosis ahsg, c3 response to oxidative stress apoe , gpx3, prdx2,sepp1,cycs vasodilation apoe , kng1,alb complement activation c3, cfh blood coagulation fga, kng1, f12,serpinc1 regulation of transcription, hmgb2 , nfil3,A630042L21Rik cycs, gapdh

Table 5: List of parent gene symbols of novel alternative splice isoforms with over- represented GO attributes by FuncAssociate

extracelular endopeptidase glycolysis lipid transport space inhibitor activity GO:0005615 GO:0004866 GO:0006096 GO:0005319

afp x ahsg x x aldoc x apoa1 x x apoa4 x x apoc3 x x apoe x x c3 x x col1a1 x cp x ecm1 x es1 x f12 x fetub x x fga x fn1 x gapdh x gpx3 x hgfac x hp x kng1 x x mdh1 x mup5 x pi16 x pkm2 x prg4 x robo1 x sepp1 x serpina1 x serpinc1 x x serpinf2 x x spp2 x

Table 6: Genes previously reported as involved in various types of cancers

Table 6a: Genes reported by other studies as involved in Gene Reference

ADAM metallopeptidase Yamada D, Ohuchida K, K M, et al. Increased expression of ADAM 9 and ADAM 15 mRNA in domain 9 pancreatic cancer. Anticancer Res 2007;27(2):393-8

Bcl2-associated Liao Q, Ozawa F, Friess H, et al. The anti-apoptotic protein BAG-3 is overexpressed in pancreatic athanogene 3 cancer and induced by heat stress in pancreatic cancer cell lines. FEBS Letters 2001;503(2-3):151-7

Tsukuda H, Matsumurs Y, Inoue T, et al. Diagnostic application of CD44 variant expression in Cd44 pancreatic juice for detection of pancreatic neoplasm. Anticancer Res 2001;21(3c):2175-83

Aust G, Steinart M, Schultx A, Wahlbuhl M, Hamann J, Wobus M. CD97, but Not Its Closely Related EGF-TM7 Family Member EMR2, Is Expressed on Gastric, Pancreatic, and Esophageal . Cd97 American Journal of clinical pathology 2002;118(5):699-707. Stridsberg M, Oberg K, Li Q, Engstrom Q, LundQvist J. Measurements of , chromogranin B (secretogranin I), chromogranin C (secretogranin II) and pancreastatin in plasma and urine from patients with carcinoid tumours and endocrine pancreatic tumours. Journal of Endocrinilogy Chromogranin b 1995;144(1):49-59

Dancer J, Takei H, Ro Jae Y, Lowery-Nordberg M. Coexpression of EGFR and HER-2 in pancreatic Epidermal growth factor ductal adenocarcinoma: A comparative study using immunohistochemistry correlated with gene receptor amplification by fluorescencent in situ hybridization. Oncology Reports 2008:151-5.

Insulin like growth factor Frystyk J, Skjærbæk C, Zapf J, Ørskov H. Increased levels of circulating free insulin-like growth binding protein 2 factors in patients with non-islet cell tumour hypoglycaemia. Diabetologia 1998;41(5):589-94.

Sebens Muerkoster S, Werbing V, Sipos B, et al. Drug-induced expression of the cellular adhesion molecule L1CAM confers anti-apoptotic protection and chemoresistance in pancreatic ductal L1 cell adhesion molecule adenocarcinoma cells. Oncogene 2006;26(19):2759-68.

Erkan M, Kleeff J, Gorbachevski A, et al. Periostin Creates a Tumor-Supportive Microenvironment in Perostin the Pancreas by Sustaining Fibrogenic Stellate Cell Activity. Gastroenterology 2007;132(4):1447-64

I Esposito RPMC-HUBFBSRHKNGJKHFPS. Tenascin C and annexin II expression in the process of Tenascin c pancreatic carcinogenesis. The Journal of Pathology 2006;208(5):673-85

Loukopoulos P, Shibata T, Katoh H, et al. Genome-wide array-based comparative genomic hybridization analysis of pancreatic adenocarcinoma: Identification of genetic indicators that predict Vinculin patient outcome. Cancer Science 2007;98(3):392-400. Table 6b:Genes reported by studies as involved in other cancer types

Gene Reference

Acyl CoA Song B-L, Wang C-H, Yao X-M, et al. Human acyl-CoA:cholesterol acyltransferase 2 acetyltransferase2 in intestinal Caco-2 cells and in hepatocellular . Biochem J 2006;394(3):617-26.

Chatterjee M, Mohapatra S, Ionan A, et al. Diagnostic Markers of by High-Throughput Casein kinase2 Antigen Cloning and Detection on Arrays. Cancer Res 2006;66(2):1181-90

Gardina P, Clark T, Shimada B, et al. and differential gene expression in colon Cortactin cancer detected by a whole genome array. BMC 2006;7(1):325.

Eukaryotic initiation Chatterjee M, Mohapatra S, Ionan A, et al. Diagnostic Markers of Ovarian Cancer by High-Throughput factor 5A Antigen Cloning and Detection on Arrays. Cancer Res 2006;66(2):1181-90 Jian-feng Lin JXH-yTXGQ-xCQGG-jXJ-dSF-kZ. Identification of candidate biomarkers in prostate needle biopsy specimens using proteomic analysis. International Journal of Filamin alpha Cancer 2007;121(12):2596-605 Fong S, Mounkes L, Liu Y, et al. Functional identification of distinct sets of antitumor activities mediated by the FKBP gene family. Proceedings of the National Academy of Sciences FK506 binding protein1a 2003;100(24):14253-8.

Larramendy ML, Niini T, Elonen E, et al. Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A Granulin microarray analysis. Haematologica 2002;87(6):569-77. Rossato M, Barban M, Vettor R. Elevated plasma levels of the novel hormone INSL3 in a woman with Insulin like protein 3 metastatic ovarian cancer. International journal of Biological Markers 2007;22(2):159-60.

Inter-alpha trypsin Piñeiro M, Alava MA, González-Ramón N, et al. ITIH4 Serum Concentration Increases during Acute- inhibitor heavy chain 4 Phase Processes in Human Patients and Is Up-Regulated by Interleukin-6 in Hepatocarcinoma HepG2 protein Cells. Biochemical and Biophysical Research Communications 1999;263(1):224-9. Choi B, Yousin S, Kim W-H, Christ L, Park J, Bae C-D. Downregulation of regenerating islet-derived Regenerating islet- 3 alpha (REG3A) in primary human gastric adenocarcinomas. Experimental and Molecular Medicine derived 3 alpha 2007;39(6):796.

Gardina P, Clark T, Shimada B, et al. Alternative splicing and differential gene expression in colon Tropomyosin1 cancer detected by a whole genome exon array. BMC Genomics 2006;7(1):325.

Vascular cell adhesion Shioi K-i, Komiya A, Hattori K, et al. Vascular Cell Adhesion Molecule 1 Predicts Cancer-Free molecule 1 Survival in Clear Cell Renal Carcinoma Patients. Clin Cancer Res 2006;12(24):7339-46.

Table 7: Eighty one known variant proteins with quantitative data (levels in plasma from tumor bearing mice relative to controls) based on isotopic ratios

Proteins identified with multiple spectra for the unique peptide and with average expression ratios > 2-fold with 95% confidence interval exclude 1 Identifier Gene parent gene average standar symbol description expression d error ratio of mean (mutant / normal) tissue factor pathway inhibitor, ENSMUSG00000027082|ENSMUST00000090732|ENSMUSP0000008 isoform 8235_s2_e707_1_rf0_c1_n0| Tfpi CRA_c 2.17 1.09 butyrophilin ENSMUSG00000020490|ENSMUST00000020792|ENSMUSP0000002 related 1 0792_s2_e827_1_rf0_c1_n0| Butr1 isoform a 2.14 1.20 neuroplastin, ENSMUSG00000032336|ENSMUST00000034887|ENSMUSP0000003 isoform 4887_s2_e845_1_rf0_c1_n0| Nptn CRA_a 1.63 1.24 insulin-like growth factor ENSMUSG00000036256|ENSMUST00000046746|ENSMUSP0000004 binding 5057_s2_e848_1_rf0_c1_n0| Igfbp7 protein 7 3.19 1.10 granulin, isoform M11C11598_3_s479_e617_1_rf2_c1_n0| Grn CRA_d 4.36 1.11 alpha-2-HS- glycoprotein, isoform M16C2151_9_s71_e848_1_rf2_c1_n0| ahsg CRA_d 1.80 1.17 immunoglob ulin lambda ENSMUSG00000061944|ENSMUST00000074329|ENSMUSP0000007 chain C3 3937_s2_e314_1_rf0_c1_n0| NULL region 2.50 1.05 complement component 8, alpha polypeptide, ENSMUSG00000035031|ENSMUST00000048947|ENSMUSP0000004 isoform 7606_s2_e1763_1_rf0_c1_n0| C8a CRA_c 2.34 1.03 extracellular matrix protein 1, isoform M3C6105_13_s107_e1808_1_rf0_c1_n0| Ecm1 CRA_b 4.12 1.32 complement ENSMUSG00000029656|ENSMUST00000031663|ENSMUSP0000003 component 8, 1663_s2_e1769_1_rf0_c1_n0| C8b beta subunit 1.42 1.07 solute carrier family 25 (mitochondri al carrier; phosphate carrier), member 23, isoform M17C6471_1_s68_e1592_1_rf1_c1_n0| Slc25a23 CRA_b 4.68 1.12 ENSMUSG00000027350|ENSMUST00000028826|ENSMUSP0000002 chromograni 8826_s2_e2033_1_rf0_c1_n0| Chgb n B 2.83 1.23 interferon receptor 2 isoform b M16C6804_1_s320_e1076_1_rf0_c1_n0| Ifnrb precursor 2.72 1.07 von ENSMUSG00000001930|ENSMUST00000001995|ENSMUSP0000000 Willebrand 1995_s2_e8441_1_rf0_c1_n0| Vwf factor 3.93 1.05 complement ENSMUSG00000058952|ENSMUST00000077918|ENSMUSP0000007 component 7074_s2_e1811_1_rf0_c1_n0| Cfi factor i 5.07 1.03 mCG15916, ENSMUSG00000015451|ENSMUST00000015595|ENSMUSP0000001 isoform 5595_s2_e5204_1_rf0_c1_n0| C4a CRA_b 1.62 1.04 ENSMUSG00000022875|ENSMUST00000023589|ENSMUSP0000002 Kininogen-1 3589_s2_e1985_1_rf0_c1_n0| Kng1 isoform1 1.92 1.07 ENSMUSG00000031444|ENSMUST00000033821|ENSMUSP0000003 3821_s2_e1481_1_rf0_c1_n0| F10 F10 protein 2.37 1.03 epidermal growth factor ENSMUSG00000020122|ENSMUST00000020329|ENSMUSP0000002 receptor 0329_s2_e3632_1_rf0_c1_n0| Egfr isoform 1 2.15 1.06 mCG12867, ENSMUSG00000048126|ENSMUST00000056925|ENSMUSP0000005 isoform 7131_s2_e7970_1_rf0_c1_n0| Col6a3 CRA_b 2.63 1.26 ENSMUSG00000031640|ENSMUST00000026907|ENSMUSP0000002 kallikrein B, 6907_s2_e1916_1_rf0_c1_n0| Klkb1 plasma 1 2.57 1.05 regenerating ENSMUSG00000071356|ENSMUST00000101272|ENSMUSP0000009 islet-derived 8829_s2_e527_1_rf0_c1_n0| Reg3a 3 alpha 4.72 1.32 protein tyrosine phosphatase, receptor type, ENSMUSG00000020154|ENSMUST00000020363|ENSMUSP0000002 B, isoform 0363_s2_e2171_1_rf0_c1_n0| Ptprb CRA_b 3.41 1.40 shisa ENSMUSG00000025647|ENSMUST00000026737|ENSMUSP0000002 homolog 5 6737_s2_e707_1_rf0_c1_n0| Scotin isoform 1 2.97 1.32 insulin-like growth factor binding protein 2, ENSMUSG00000039323|ENSMUST00000047328|ENSMUSP0000004 isoform 6610_s2_e917_1_rf0_c1_n0| Igfbp2 CRA_a 3.13 1.09 mCG120448, isoform M4C10653_1_s2_e11219_1_rf2_c1_n0| NULL CRA_a 3.20 1.05 coagulation factor XIII, A1 subunit, ENSMUSG00000039109|ENSMUST00000037491|ENSMUSP0000004 isoform 8667_s2_e2198_1_rf0_c1_n0| F13a1 CRA_b 2.95 1.05 extracellular matrix protein 1, ENSMUSG00000028108|ENSMUST00000029753|ENSMUSP0000002 isoform 9753_s2_e1679_1_rf0_c1_n0| Ecm1 CRA_a 2.83 1.05 extracellular ENSMUSG00000028108|ENSMUST00000074315|ENSMUSP0000007 matrix 3924_s2_e1304_1_rf0_c1_n0| Ecm1 protein 1 4.44 1.20 mCG134312, ENSMUSG00000038521|ENSMUST00000068797|ENSMUSP0000006 isoform 6999_s2_e2066_1_rf0_c1_n0| NULL CRA_a 2.60 1.01 SH3-binding domain glutamic acid-rich protein like, SH3BGR isoform MXC4909_1_s410_e1124_1_rf0_c1_n0| L3 CRA_b 2.70 1.10 insulin-like growth factor ENSMUSG00000048583|ENSMUST00000053222|ENSMUSP0000005 2, isoform 2434_s2_e542_1_rf0_c1_n0| Igf2 CRA_a 2.37 1.06 mCG15916, ENSMUSG00000073418|ENSMUST00000069507|ENSMUSP0000006 isoform 9418_s2_e5216_1_rf0_c1_n0| C4a CRA_c 4.99 1.05 Angiotensino gen (serpin peptidase inhibitor, ENSMUSG00000031980|ENSMUST00000063278|ENSMUSP0000006 clade A, 6488_s2_e1448_1_rf0_c1_n0| Agt member 8 1.75 1.07 CD48 antigen, ENSMUSG00000015355|ENSMUST00000068584|ENSMUSP0000006 isoform 4241_s2_e722_1_rf0_c1_n0| Cd48 CRA_b 1.69 1.00 complement M15C129_1_s122_e2471_1_rf1_c1_n0| C6 component 6 5.26 1.00 vascular cell adhesion molecule 1, isoform M3C8092_1_s2_e344_1_rf2_c1_n0| Vcam1 CRA_b 1.72 1.00 secreted and ENSMUSG00000025165|ENSMUST00000026162|ENSMUSP0000002 transmembra 6162_s2_e578_1_rf0_c1_n0| Sectm1a ne 1A 6.44 1.21 afamin, isoform M5C6453_2_s35_e1868_1_rf1_c1_n0| Afm CRA_d 2.74 1.11 complement factor H- ENSMUSG00000057037|ENSMUST00000027612|ENSMUSP0000002 related 7612_s2_e2426_1_rf0_c1_n0| NULL protein C 3.74 1.24 lymphocyte specific 1, ENSMUSG00000018819|ENSMUST00000018963|ENSMUSP0000001 isoform 8963_s2_e998_1_rf0_c1_n0| Lsp1 CRA_c 2.97 1.18 fatty acid binding protein 5, M3C293_1_s2_e368_1_rf2_c1_n0| Fabp5 epidermal 4.00 1.00 fatty acid binding protein 5, M18C5388_1_s2_e458_1_rf1_c1_n0| Fabp5 epidermal 1.22 1.08 acetyl- Coenzyme A acetyltransfer M17C923_1_s128_e1337_1_rf2_c1_n0| Acat2 ase 2 2.11 1.08 ENSMUSG00000060600|ENSMUST00000072841|ENSMUSP0000007 enolase 3, 2620_s2_e1304_1_rf0_c1_n0| Eno3 beta muscle 2.25 1.18 mCG134312, ENSMUSG00000038521|ENSMUST00000077416|ENSMUSP0000007 isoform 6632_s2_e2084_1_rf0_c1_n0| C1s CRA_a 3.15 1.05 ENSMUSG00000027435|ENSMUST00000099269|ENSMUSP0000009 6876_s2_e1934_1_rf0_c1_n0| Cd93 CD93 antigen 1.72 1.10 ENSMUSG00000027338|ENSMUST00000091288|ENSMUSP0000008 8833_s2_e764_1_rf0_c1_n0| Prnp prion protein 4.44 1.34

Proteins identified with multiple spectra for the unique peptide and with average expression ratios with 95% confidence intervals include 1 Identifier gene parent gene average standar symbol description expression d error ratio of mean (mutant / normal) mCG128253, isoform M16C2167_10_s107_e542_1_rf1_c1_n0| Kng1 CRA_c 1.09 1.08 mRNA M6C10494_1_s1445_e1496_1_rf1_c1_n0| NULL AK142517 1.93 2.07 complement ENSMUSG00000057037|ENSMUST00000023965|ENSMUSP0000002 factor H- 3965_s2_e1031_1_rf0_c1_n0| Cfhr1 related 1 1.83 1.37 insulin-like growth factor binding protein 5, ENSMUSG00000026185|ENSMUST00000027377|ENSMUSP0000002 isoform 7377_s2_e815_1_rf0_c1_n0| Igfbp5 CRA_b 1.32 1.29 lymphocyte antigen 6 complex, locus E, ENSMUSG00000022587|ENSMUST00000023251|ENSMUSP0000002 isoform 3251_s2_e410_1_rf0_c1_n0| Ly6e CRA_a 0.96 1.17 sushi domain M9C10588_1_s338_e2264_1_rf0_c1_n0| Susd5 containing 5 1.48 1.25 ENSMUSG00000020609|ENSMUST00000072432|ENSMUSP0000007 apolipoprotein 2259_s2_e11132_1_rf0_c1_n0| Apob b 3.20 1.95

Proteins identified with single spectra for the unique peptide, but with average expression ratios > 2-fold change Identifier gene parent gene description average symbol expression ratio (mutant/nor mal) mCG128256, isoform M16C2166_11_s191_e1385_1_rf0_c1_n0| Kng1 CRA_a 4.55 ENSMUSG00000031958|ENSMUST00000070004|ENSMUSP0000006 D, 8086_s2_e1454_1_rf0_c1_n0| Ldhd isoform CRA_a 2.63 ENSMUSG00000037362|ENSMUST00000100664|ENSMUSP0000009 nephroblastoma 8229_s2_e1064_1_rf0_c1_n0| Nov overexpressed gene 3.03 mCG22075, isoform M7C118_1_s2_e1001_1_rf0_c1_n0| GpVI CRA_b 2.86 M5C7372_1_s1985_e2147_1_rf2_c1_n0| NULL NULL 0.46 dickkopf homolog 3 (Xenopus laevis), M7C10036_7_s68_e1148_1_rf1_c1_n0| Dkk3 isoform CRA_d 4.17 plasminogen, isoform M17C840_5_s2_e287_1_rf2_c1_n0| Plg CRA_l 3.57 phosphoinositide-3- ENSMUSG00000034614|ENSMUST00000045153|ENSMUSP0000003 kinase interacting protein 6921_s2_e794_1_rf0_c1_n0| Pik3ip1 1 3.33 M1C2399_2_s212_e398_1_rf0_c1_n0| NULL mRNA BC079869 2.44 ENSMUSG00000031402|ENSMUST00000033775|ENSMUSP0000003 membrane protein, 3775_s2_e1400_1_rf0_c1_n0| Mpp1 palmitoylated 0.41 ENSMUSG00000058624|ENSMUST00000075494|ENSMUSP0000007 guanine deaminase, 4937_s2_e1364_1_rf0_c1_n0| Gda isoform CRA_a 2.56 M14C7677_1_s356_e431_1_rf1_c1_n0| NULL NULL 3.33 KH-type splicing ENSMUSG00000007670|ENSMUST00000007814|ENSMUSP0000000 regulatory protein, 7814_s2_e2246_1_rf0_c1_n0| Khsrp isoform CRA_b 2.04

Proteins identified with single spectra for the unique peptide, but with average expression ratio < 2-fold change Identifier gene parent gene average symbol description expression ratio (mutant/nor mal) PDZ and LIM ENSMUSG00000028273|ENSMUST00000029941|ENSMUSP0000002 domain 5 isoform 9941_s2_e1775_1_rf0_c1_n0| Pdlim5 ENH3 1.03 M5C6439_16_s2_e365_1_rf1_c1_n0| Alb albumin 1.96 epidermal growth factor-containing fibulin-like extracellular matrix ENSMUSG00000024909|ENSMUST00000025843|ENSMUSP0000002 protein 2, isoform 5843_s2_e1331_1_rf0_c1_n0| Efemp2 CRA_b 1.96 M5C5274_1_s2_e95_1_rf0_c1_n0| NULL NULL 0.66 M1C10834_9_s770_e824_1_rf2_c1_n0| NULL NULL 0.95 complement factor M17C4115_21_s365_e1982_1_rf0_c1_n0| Cfb B, isoform CRA_b 1.79 ceruloplasmin, M3C675_1_s2564_e2861_1_rf1_c1_n0| Cp isoform CRA_c 0.99 complement component 3, M17C6514_13_s2_e2045_1_rf2_c1_n0| C3 isoform CRA_a 1.39 latent transforming growth factor beta ENSMUSG00000001870|ENSMUST00000001927|ENSMUSP0000000 binding protein 1 1927_s2_e5138_1_rf0_c1_n0| Ltbp1 isoform LTBP-1S 1.67 ENSMUSG00000006651|ENSMUST00000006828|ENSMUSP0000000 amyloid precursor- 6828_s2_e1964_1_rf0_c1_n0| Aplp1 like protein 1 1.41 immunoglobulin lambda light chain variable region M16C1747_1_s2_e293_1_rf0_c1_n0| NULL precursor 0.98 M6C9766_7_s392_e2513_1_rf2_c1_n0| C1r mCG141466 1.32 ENSMUSG00000069919|ENSMUST00000093208|ENSMUSP0000009 hemoglobin alpha, 0896_s2_e422_1_rf0_c1_n0| Hba-a1 adult chain 1 1.01

Table 8 Primers designed for the novel peptide sequences for RT-PCR validations name symbol peptide NO. OF Left Right Product SPECTRA primer primer size novel pkm2 CLAAALIVLTES 5 tgtttagcag gtacctggcc 66 pyruvate GR cagctttgat acttggtga kinase variant (56.39) (59.54) novel malate mdh1 NHLVEALDLSCP 10 cgtaaccat agagctctctt 75 dehydrogen QR cttgttgaag tcacgtcacc ase 1, NAD variant ctc (58.9) (58.7) novel cycs ASQAAGFSYTD 27 ctgagtgga gatgcctttgt 65 cytochrome ANK aggcaagtc tcttgttgg c variant agg (62.3) (58.3) novel solute slc19a1 ILRLPIHTCPLLG 16 attctccggc agtccatgga 65 carrier family ELDYR ttcccatc gtctgtagtcc 19 (sodium/hyd (59.9) aa (60.5) rogen) variant novel es1 AISESSVVLGTN 9 tccacagag gatattcttgt 62 esterase 1 LR ctatttctga tgcgcaggtt variant gagt (59.24) (57.39) novel NULL CELAEQMTSLL 11 cagtgtact ccaccctgac 69 PCTAIRE- ER acctggagg tctttccagt motif protein kinase 2, tgtgaat (59.15) isoform (60.72) CRA_b variant novel ppil2 WSSLRPYLVWI 7 gattggaaa gagtagaag 63 peptidylproly VR tggtcctcac ctcctgcctca l isomerase- like 2 variant tc (58.4) (57.35) gamma GCGCA ACATCT 65 actin AGTACT GCTGGA (positive control) CTGTGT AGGTGG GGA (60) AC (60)