BioVendor Research and Diagnostic Products, a.s. European Union: USA, Canada and Mexico: China – Mainland Office: Karasek 1767/1 BioVendor GmbH BioVendor, LLC BioVendor Laboratories Ltd. 621 00 Brno Im Neuenheimer Feld 583 128 Bingham Rd., Suite 1300 Room 2917, 29/F, R & F Ying Feng Plaza No.2 CZECH REPUBLIC D-69120 Heidelberg, GERMANY Asheville, NC 28806, USA Huaqiang road, Pearl River New Town, Guangzhou, CHINA Phone: +49 6221 433 9100 Phone: +1-800-404-7807 Phone: +86 20 38065519 Phone: +420 549 124 185 Fax: +49 6221 433 9111 +1-828-575-9250 Fax: +86 20 38065529, e-mail: [email protected] Fax: +420 549 211 460 e-mail: [email protected] Fax: +1-828-575-9251 e-mail: [email protected] e-mail: [email protected] China – Hong Kong Office: BioVendor GesmbH BioVendor Laboratories Ltd. Nußdorfer Straße 20/10 Room 4008, Hong Kong Plaza, No.188 1190 Vienna, AUSTRIA Connaught Road West, Hong Kong, CHINA Phone: +43 1 89090 25 Phone: +852 28030523 Fax: +43 1 89090 2515 www.biovendor.com Fax: +852 28030525, e-mail: [email protected] e-mail: [email protected] BIOVENDOR R&D PRODUCTS

Our Products and Services

ANTIBODIES

Products The company superiority in the preparation of recombinant proteins enables us to raise excellent mouse monoclonal and rabbit and sheep polyclonal antibodies. We provide the scientific community with unique research tools helping them to obtain original data that have resulted in many publications. BioVendor’s monoclonal and polyclonal antibodies have become the backbones of many of our as well as other companies’ immunodiagnostics.

PROTEINS

Products The combination of perfectly posttranslationally processed recombinant proteins produced in cell line HEK 293 and robust E. coli recombinant production systems is crucial for accelerated development of new recombinant proteins. Together with our capability to isolate natural proteins from human or animal body fluids, BioVendor can fulfill the needs of scientists within our selected fields.

IMMUNOASSAYS

Products BioVendor’s competitive advantage is its independence from external sources of antibodies and calibrators in the development of immunodiagnostics. To date, we have developed and launched independently over 60 ELISA kits and 50 immunoassays are in the product pipeline. Many others came via technological transfer. Our kits are used in research and clinical labs of more than 60 countries including such demanding and competitive markets as the USA, EU countries and Japan.

Service BATS The BioVendor Analytical Testing Service (BATS) offers customer’s sample analysis with our immunoassays which are fully validated for clinical studies. Our advantage is that our personnel is skilled in immunoassay development and we utilize their detailed understanding of the assay performance. This allows us to modify our existing assays to unusual types of matrices. We guarantee full sample traceability, accuracy and confidentiality.

Service MULTIPLEX BioVendor provides Custom Bio-Plex® Multianalyte Determination Service using market leading multianalyte system providers such as Bio-Rad, R&D Systems, Merck Millipore and others. Save your personnel and laboratory capacities, time and money and get maximum analytical information out of minimum sample volume at a minimal expense on personnel, lab instrumentation and reagents. BioVendor enables you to quantitate up to 100 different analytes in a drop of sample, giving you the power to understand complex relationships among proteins in normal and disease states.

BIOMEDICAL SPECIMEN BANK

Products Provides various types of biological samples along with corresponding panels of data including analytical parameters, anthropometric variables and clinical information for the diagnostic industry, assay manufacturers and researchers. Our expanding portfolio of panels covers both physiological and pathological conditions. Samples are stored at -150°C, supplied on dry ice as 0.105 ml serum, urine or other body fluid, assorted in 96 microplate-format boxes. Inside this catalog, please find examples of panels we provide as well as some examples of data related to them. Dear Customer,

We are proud to introduce the 2014/2015 BioVendor Research and Diagnostic Products Catalog. This new edition of the catalog is covering the entire portfolio of our products and services designed to help you, the life science, diagnostic and biotech communities, advance your research.

As new products and services are released within the lifespan of this catalog, we will print updated brochures on a regular basis. You are welcome to contact our Marketing/Sales department, which will provide you with new information in a timely manner and/ or send you the latest updates.

Enjoy our accommodating responses to your demands including customized products, individual production of bulk quantities, and special packaging and product testing – all designed to meet your needs.

We thank you for the increasing interest in our products, and we commit ourselves to continually bringing innovative research tools to the world of life science.

Do you wish to be involved in the exciting process of development and marketing of new products? Are you interested in learning more about us? Your initiatives, ideas and inquires are gratefully welcome.

Yours faithfully,

Viktor Růžička, MD CEO

LET´S TALK! Tel: + 420 549 124 185 E-mail: [email protected] Web: www.biovendor.com

3 BIOVENDOR R&D PRODUCTS

Our History and Commitment

BioVendor – Laboratorni Medicina a.s. established its Research and Diagnostic Products Division as an emerging innovative biotech company in the South Moravian part of the Czech Republic, European Union in 1995. BioVendor R&D Products’ mission is to provide researchers and medical experts with top-quality immunodiagnostics and related biochemicals – antibodies and recombinant proteins, aimed mainly at: obesity/metabolic syndrome/diabetes, cardiovascular physiology, kidney injury, bone metabolism/osteoporosis, immune response/infection/inflammation, neural tissue damage markers, and animal model research.

BioVendor’s strength stems from its full control over the whole R&D process conducted by continuously educated researchers in new, fully-equipped labs. Our customers include the world’s top-ranking scientific institutions, pharmaceutical and biotech companies and clinical laboratories. As a result, we have recently opened branches in Germany, the USA and China, to expedite distribution, improve our customer service and to strengthen the existing worldwide network of BioVendor’s distributors.

BioVendor has established its Quality Management system since 1999 – being ISO-certified in accordance with the regulations of ISO 9001, ISO 13485 and ISO 14001.

BioVendor has become internationally recognized for its achievements in rapid launching of high-quality products – resulting in the development of biomarkers for early detection of common diseases associated with postindustrial societies. We are proud that BioVendor’s Leptin ELISA, the first commercial ELISA (1998), opened the door to investigations of fat tissue hormones and that our Adiponectin ELISA, the first kit marked as IVD in the EU, helped make routine clinical testing of this hormone possible.

BioVendor’s motivated team is accustomed to being in the forefront of novel research tool development. 1994 – Leptin, the first fat tissue hormone described 1998 – the first commercial Leptin ELISA – released by BioVendor 2001 – Resistin, possible link between diabetes and obesity described 2002 – the most often referred Resistin ELISA – released by BioVendor 2003 – BioVendor’s Adiponectin ELISA 2005 – the first Adipocyte FABP ELISA – developed by BioVendor 2006 – the first commercial Clusterin ELISA – released by BioVendor 2007 – the first commercial ZA2G ELISA – released by BioVendor 2008 – the first commercial FGF-21 ELISA – released by BioVendor 2009 – the first commercial SP-A ELISA – released by BioVendor 2010 – BioVendor was granted by the European patent EP 1 904 082 for Adipocyte FABP ELISA 2011 – the first commercial Serum Uromodulin ELISA – patent pending 2012 – the first commercial Lecithin-Cholesterol Acyltransferase ELISA – released by BioVendor 2013 – the first commercial Pancreatic-Derived Factor ELISA – released by BioVendor

These and many other achievements are the fruit of the unmatched dedication of our team members as well as BioVendor’s creative leadership and boldness in developing new research projects for novel biomarkers shortly after the first interesting results have been published.

4 Purchasing information and conditions of sale

Following the licence agreements made and entered into by BioVendor and its suppliers or licensors, the sale of some products is restricted to certain areas. Since it is not possible to specify this for each product, we cannot guarantee that all products stated in the catalogue are available in all countries. Please check their availability at [email protected].

Ordering Orders can be placed either by e-mail, fax, phone or post. Please use our website at www.biovendor.com to order online.

Distribution Network BioVendor’s products can be ordered all over the world either directly from BioVendor headquarters, BioVendor subsidiaries or from our network of local distributors. Your orders will be forwarded to the office corresponding to your market area. Please contact either BioVendor’s sales department or consult our website for details.

Required Information • Purchase order number (for credit card numbers, please enquire) • Product catalog number and specification • Product size/quantity • Delivery address • Billing address (if different) • Contact name, e-mail address, and phone number • VAT number (for E.U. countries only)

Pricing and Payment Terms Prices are subject to change without notice. Payment terms are 30 days from invoice date. BioVendor does not agree to, and is not bound by, any other terms or conditions that have not been expressly agreed to in writing by a duly authorized officer of BioVendor. Prepayment against a proforma invoice may be required for new customers. The present catalog is intended for use with a supplementary price list. Prices are net and ex-works. Please visit the BioVendor website at www.biovendor.com and contact BioVendor or our local distributor for the current price list.

Bulk Quantities To better serve our customers, BioVendor offers extended sizes for our proteins and antibodies upon request. Please contact either BioVendor’s sales department or our local distributor for alternative quantity options and applicable pricing.

Shipping BioVendor reserves the right to select the method of packaging and shipping that best ensures efficient tracking and stability of the product over the course of shipment. Shipping and handling costs are prepaid and added to the invoice. The use of a purchaser’s account number can be arranged only when expressly required by the purchaser. Any damage during shipment is covered by the warranty provided in these terms and conditions.

Resale Prohibited In the absence of an expressed written agreement to the contrary, all products sold by BioVendor are for the exclusive use of the purchaser and are not to be resold.

Product Specifications and Uses With the exception of those immunoassay kits explicitly marked with IVD CE, which are registered in accordance with the requirements and the statutory instruments pursuant to In Vitro Diagnostic Medical Devices Directive 98/79/EC or in vitro diagnostic use within European Union countries, BioVendor’s products are furnished for research use only. They must not be used as drugs, veterinary drugs, cosmetics, agricultural or pesticidal products, food additives or household chemicals.

5 Technical Assistance Contact either BioVendor or our local distributor for technical assistance. Please be prepared to provide all relevant information. (problem specification or description, catalog number, lot number, etc.)

Claims and Returns Products may not be returned without prior authorization. Contact either BioVendor branches or our local distributor for authorization and instructions. Packaging and products should be inspected immediately upon receipt. Notification of damage, shortage, defects or incorrect shipping should be given immediately by e-mail or fax. Claims against the quality or function of our products should contain the product catalog number, lot number and detailed problem description. Raw data obtained with a product that is the subject to the claim may be required.

Warranty All BioVendor’s products are guaranteed to meet or exceed specifications as given in our product datasheets when used under normal laboratory conditions. Should any product fail to perform as warranted, upon notification, BioVendor shall promptly replace it, free of charge. BioVendor’s obligations and purchaser’s sole remedy is limited to such replacement of the product or, at the opinion of BioVendor, refund of the original purchase price.

BioVendor does not make any other warranty or representation whatsoever, whether expressed or implied, with respect to these products. In particular, BioVendor does not make any warranty of suitability, non-infringement, merchantability or fitness for any particular purpose of any product. In no event shall BioVendor be liable for incidental, consequential or punitive damages.

6 TABLE OF CONTENTS

ANTIBODIES 7

PROTEINS 19

IMMUNOASSAYS 65

SERVICES SERVICES BATS 201 MULTIPLEX 203

BIOMEDICAL SPECIMEN BANK 209

INDEX 215

7 8 ANTIBODIES ANTIBODIES

Antibodies

MONOCLONAL ANTIBODIES Monoclonal antibodies are prepared using hybridoma technology, fusing the spleen cells of immunized mice with the cells of the mouse myeloma Sp2/0 cell line. The resultant hybridoma cells are selected according to their ability to produce antibodies of the required specificity. The hybridoma cells producing the highest quality antibodies are then cloned and cultivated. Monoclonal antibodies are protein-G or protein-A purified.

POLYCLONAL ANTIBODIES Polyclonal antibodies are prepared by immunizing experimental animals using optimized immunization protocols. Sera from immunized rabbits, goats, cows or sheep or the yolk from chicken eggs provide the source of specific antibodies. The host animal species is specified in the corresponding product name subtitle. Polyclonal antibodies are affinity purified on immunizing antigen-immobilized columns.

FEATURES Formulation All antibodies are shipped as lyophilized materials. The antibodies are 0.4 μm filtered prior to lyophilization. Reconstitution Use deionized water to reconstitute the lyophilized antibodies. Easy conjugation To make antibody conjugation or chemical immobilization easy, PBS buffer is used as the lyophilization medium.

The buffer is free of azide or any NH2-group containing compounds. Storage Store the lyophilized antibodies at -20 °C. Quality Control Test Antibody content determination: Protein concentration determined by BCA method using BSA as a calibrator Antibody purity determination: SDS PAGE (12% PAGE, reduction buffer, 5 μg/lane) Antibody titer determination: Indirect ELISA

ABBREVIATIONS USED ELISA Enzyme-Linked Immunosorbent Assay IHC Immunohistochemistry WB Western Blotting IF Immunofluorescence IP Immunoprecipitation

9 ANTIBODIES C –

A CLONE/ REACTIVE ISOTYPE SPECIES APPLICATIONS CATALOG NUMBER SIZE

ANTI-HUMAN ACYLATION STIMULATING PROTEIN 4H3 Hu ELISA, WB RD1820711004H3 0.1 mg Mouse Monoclonal Antibody IgG1 ASP

ANTI-HUMAN ADIPOCYTE FABP predom. Hu ELISA, WB RD184037100 0.1 mg Goat Polyclonal Antibody IgG AFABP, FABP4, Adipocyte Fatty Acid Binding Protein

ANTI-HUMAN ADIPOCYTE FABP predom. Hu WB, IHC RD181037050 0.05 mg Rabbit Polyclonal Antibody IgG AFABP, FABP4, Adipocyte Fatty Acid Binding Protein

ANTI-HUMAN ADIPONECTIN predom. Hu ELISA, WB RD184023100 0.1 mg Goat Polyclonal Antibody (HEK293 antigen) IgG Acrp30, GBP28, AdipoQ

ANTI-HUMAN ADIPONECTIN predom. Hu ELISA, WB RD181023100 0.1 mg Rabbit Polyclonal Antibody (HEK293 antigen) IgG Acrp30, GBP28, AdipoQ

ANTI-HUMAN ADIPONECTIN predom. Hu WB RD181023220 0.1 mg Rabbit Polyclonal Antibody (E.coli antigen) IgG Acrp30, GBP28, AdipoQ

ANTI-HUMAN ADIPONECTIN predom. Hu ELISA, WB RD184023100-01 0.1 mg Sheep Polyclonal Antibody (HEK293 antigen) IgG Acrp30, GBP28, AdipoQ

ANTI-MURINE ADIPONECTIN predom. Mo WB RD281023100 0.1 mg Rabbit Polyclonal Antibody (HEK293 antigen) IgG Acrp30, GBP28, AdipoQ

ANTI-PORCINE ADIPONECTIN predom. Porcine WB RD581023100 0.1 mg Rabbit Polyclonal Antibody (HEK293 antigen) IgG Acrp30, GBP28, AdipoQ

ANTI-PORCINE ADIPONECTIN predom. Porcine ELISA, WB RD584023100 0.1 mg Sheep Polyclonal Antibody (HEK293 antigen) IgG Acrp30, GBP28, AdipoQ

ANTI-HUMAN ADIPOPHILIN predom. Hu ELISA, WB RD181161100 0.1 mg Rabbit Polyclonal Antibody IgG Perilipin-2, Adipose differentiation-related protein, ADRP, PLIN2, ADFP

ANTI-HUMAN ADIPOPHILIN predom. Hu ELISA, WB RD184161100 0.1 mg Sheep Polyclonal Antibody IgG Perilipin-2, Adipose differentiation-related protein, ADRP, PLIN2, ADFP

ANTI-HUMAN AGOUTI-RELATED PROTEIN predom. Hu ELISA, WB, IHC RD181030050 0.05 mg Rabbit Polyclonal Antibody IgG AGRP

ANTI-HUMAN ALLOGRAFT INFLAMMATORY FACTOR-1 predom. Hu ELISA, WB RD184204100 0.1 mg Sheep Polyclonal Antibody IgG AIF-1, Ionized calcium-binding adapter molecule 1, Protein G1, AIF1, G1, IBA1

ANTI-HUMAN ANGIOPOIETIN-LIKE PROTEIN 3 predom. Hu ELISA, WB RD181092100 0.1 mg Rabbit Polyclonal Antibody IgG ANGPTL3

10 For more information please go to www.biovendor.com ANTIBODIES ANTIBODIES

CLONE/ REACTIVE ISOTYPE SPECIES APPLICATIONS CATALOG NUMBER SIZE

ANTI-HUMAN ANGIOPOIETIN-LIKE PROTEIN 3 predom. Hu ELISA, WB RD184092100 0.1 mg Sheep Polyclonal Antibody IgG ANGPTL3

ANTI-HUMAN ANGIOPOIETIN-LIKE PROTEIN 4 predom. Hu ELISA, WB RD181073100-01 0.1 mg Rabbit Polyclonal Antibody IgG ANGPTL4, FIAF

ANTI-HUMAN ANGIOPOIETIN-LIKE PROTEIN 4 predom. Hu ELISA, WB RD184073100-01 0.1 mg Sheep Polyclonal Antibody IgG ANGPTL4, FIAF

ANTI-HUMAN ANGIOPOIETIN-LIKE PROTEIN 4 predom. Hu ELISA, WB RD184073100-02 0.1 mg Sheep Polyclonal Antibody (HEK293 antigen) IgG ANGPTL4, FIAF

ANTI-HUMAN ANGIOSTATIN predom. Hu WB RD181056100 0.1 mg Rabbit Polyclonal Antibody IgG x

ANTI-HUMAN APOLIPOPROTEIN D predom. Hu ELISA, WB RD181118100 0.1 mg Rabbit Polyclonal Antibody IgG Apo-D

ANTI-HUMAN APOLIPOPROTEIN D predom. Hu ELISA, WB RD184118100 0.1 mg Sheep Polyclonal Antibody IgG Apo-D

ANTI-HUMAN ARGINASE-I (LIVER TYPE) 6G3 Hu ELISA, WB RD182028100 0.1 mg Mouse Monoclonal Antibody IgG1 EC 3.5.3.1, L-Arginine Aminohydrolase

ANTI-HUMAN BETA-MICROSEMINOPROTEIN predom. Hu ELISA, WB RD181140100 0.1 mg Rabbit Polyclonal Antibody IgG Prostate secreted seminal plasma protein, Prostate secretory protein PSP94, PSP-94, IGBF, PN44

ANTI-HUMAN BETA-MICROSEMINOPROTEIN predom. Hu ELISA, WB RD184140100 0.1 mg Sheep Polyclonal Antibody IgG Prostate secreted seminal plasma protein, Prostate secretory protein PSP94, PSP-94, IGBF, PN44

ANTI-HUMAN CARDIOTROPHIN-1 1F3 Hu WB RD1820261001F3 0.1 mg Mouse Monoclonal Antibody IgG1 CT-1, CTF1

ANTI-HUMAN CARDIOTROPHIN-1 3G6D9 Hu WB RD182026100-01 0.1 mg Mouse Monoclonal Antibody IgG1 CT-1, CTF1

ANTI-HUMAN CARDIOTROPHIN-1 predom. Hu WB RD181026100 0.1 mg Rabbit Polyclonal Antibody IgG CT-1, CTF1

ANTI-HUMAN CARTILAGE OLIGOMERIC MATRIX PROTEIN 12C4 Hu ELISA, IHC RD182080100C4 0.1 mg (COMP) IgG1 Mouse Monoclonal Antibody COMP, Thrombospondin-5, TSP5

[email protected] 11 ANTIBODIES F –

C CLONE/ REACTIVE ISOTYPE SPECIES APPLICATIONS CATALOG NUMBER SIZE

ANTI-HUMAN CARTILAGE OLIGOMERIC MATRIX PROTEIN 16F12 Hu ELISA, WB, IHC RD182080100F1 0.1 mg (COMP) IgG1 Mouse Monoclonal Antibody COMP, Thrombospondin-5, TSP5

ANTI-HUMAN CARTILAGE OLIGOMERIC MATRIX PROTEIN 17C10 Hu ELISA, IHC RD182080100C1 0.1 mg (COMP) IgG1 Mouse Monoclonal Antibody COMP, Thrombospondin-5, TSP5

ANTI-HUMAN CATHEPSIN K 3F9 Hu WB, IHC RD1820741003F9 0.1 mg Mouse Monoclonal Antibody IgG2b EC 3.4.22.38

ANTI-HUMAN CLARA CELL PROTEIN predom. Hu ELISA, WB, IHC RD181022220-01 0.1 mg Rabbit Polyclonal Antibody IgG CC16, CC10, Uteroglobin, Urinary protein 1, Clara cell secretory protein

ANTI-HUMAN CLUSTERIN Hs-3 Hu ELISA, WB, ICC, RD182034110-H3 0.1 mg Mouse Monoclonal Antibody IgG1 IF, IHC Apolipoprotein J, Apo J

ANTI-CANINE CLUSTERIN predom. Canine WB RD481034100 0.1 mg Rabbit Polyclonal Antibody IgG Apolipoprotein J, Apo J

ANTI-CANINE CLUSTERIN predom. Canine ELISA, WB RD484034100 0.1 mg Sheep Polyclonal Antibody IgG Apolipoprotein J, Apo J

ANTI-RAT CLUSTERIN predom. Rat ELISA, WB RD381034100 0.1 mg Rabbit Polyclonal Antibody IgG Apolipoprotein J, Apo J

ANTI-HUMAN CXCL12 predom. Hu WB RD181175100 0.1 mg Rabbit Polyclonal Antibody IgG Stromal cell-derived factor 1, SDF-1a, C-X-C motif chemokine 12, Pre-B cell growth-stimulating factor, PBSF, hIRH

ANTI-HUMAN CXCL12 predom. Hu WB RD184175100 0.1 mg Sheep Polyclonal Antibody IgG Stromal cell-derived factor 1, SDF-1a, C-X-C motif chemokine 12, Pre-B cell growth-stimulating factor, PBSF, hIRH

ANTI-HUMAN CYSTATIN C predom. Hu ELISA, WB RD181009220 0.1 mg Rabbit Polyclonal Antibody IgG Post G-globulin, CST 3

ANTI-HUMAN CYSTATIN C predom. Hu ELISA, WB RD181009100 0.1 mg Rabbit Polyclonal Antibody (E. coli antigen) IgG Post G-globulin, CST3

ANTI-HUMAN CYSTATIN C predom. Hu ELISA, WB RD184009220 0.1 mg Sheep Polyclonal Antibody IgG Post G-globulin, CST 3

ANTI-HUMAN CYSTATIN C predom. Hu ELISA, WB RD184009100 0.1 mg Sheep Polyclonal Antibody (E. coli antigen) IgG Post G-globulin, CST3

12 For more information please go to www.biovendor.com ANTIBODIES ANTIBODIES

CLONE/ REACTIVE ISOTYPE SPECIES APPLICATIONS CATALOG NUMBER SIZE

ANTI-CANINE CYSTATIN C predom. Canine ELISA, WB RD481009100 0.1 mg Rabbit Polyclonal Antibody IgG Post G-globulin, CST3

ANTI-MOUSE CYSTATIN C predom. Mouse ELISA, WB RD281009100 0.1 mg Rabbit Polyclonal Antibody IgG Post G-globulin, CST3

ANTI-CANINE CYSTATIN C predom. Canine ELISA, WB RD484009100 0.1 mg Sheep Polyclonal Antibody IgG Post G-globulin, CST3

ANTI-MOUSE CYSTATIN C predom. Mouse ELISA, WB RD284009100 0.1 mg Sheep Polyclonal Antibody IgG Post G-globulin, CST3

ANTI-RAT CYSTATIN C predom. Rat ELISA, WB RD384009100 0.1 mg Sheep Polyclonal Antibody IgG Post G-globulin, CST3

ANTI-HUMAN ENDOSTATIN predom. Hu ELISA, WB RD181076100 0.1 mg Rabbit Polyclonal Antibody IgG

ANTI-HUMAN Ep-CAM MK-1-25 Hu ELISA, WB RD182024110-25 0.1 mg Mouse Monoclonal Antibody IgG1 MK-1

ANTI-HUMAN Ep-CAM MK-1-410 Hu ELISA, WB RD182024110-10 0.1 mg Mouse Monoclonal Antibody IgG1 MK-1

ANTI-HUMAN EPIDERMAL FABP predom. Hu ELISA, WB RD181060100 0.1 mg Rabbit Polyclonal Antibody IgG EFABP, FABP5, Epidermal Fatty Acid Binding Protein

ANTI-HUMAN EPIDERMAL FABP predom. Hu ELISA, WB RD184060100 0.1 mg Sheep Polyclonal Antibody IgG EFABP, FABP5, Epidermal Fatty Acid Binding Protein

ANTI-HUMAN FETUIN-A (AHSG) predom. Hu ELISA, WB, ITB RD184036100 0.1 mg Goat Polyclonal Antibody IgG Alpha-2 HS Glycoprotein, AHSG

ANTI-HUMAN FETUIN-A (AHSG) predom. Hu WB, IHC, ELISA RD181036100 0.1 mg Rabbit Polyclonal Antibody IgG Alpha-2 HS Glycoprotein, AHSG

ANTI-HUMAN FIBROBLAST GROWTH FACTOR 19 predom. Hu ELISA, WB RD181107100 0.1 mg Rabbit Polyclonal Antibody IgG FGF-19

ANTI-HUMAN FIBROBLAST GROWTH FACTOR 19 predom. Hu ELISA, WB RD184107100 0.1 mg Sheep Polyclonal Antibody IgG FGF-19

ANTI-HUMAN FIBROBLAST GROWTH FACTOR 21 predom. Hu ELISA, WB RD181108100 0.1 mg Rabbit Polyclonal Antibody IgG FGF-21

[email protected] 13 ANTIBODIES N –

F CLONE/ REACTIVE ISOTYPE SPECIES APPLICATIONS CATALOG NUMBER SIZE

ANTI-MOUSE FIBROBLAST GROWTH FACTOR 21 predom. Mo ELISA, WB RD281108100 0.1 mg Rabbit Polyclonal Antibody IgG FGF-21

ANTI-HUMAN FIBROBLAST GROWTH FACTOR 21 predom. Hu ELISA, WB RD184108100 0.1 mg Sheep Polyclonal Antibody IgG FGF-21

ANTI-HUMAN FIBROBLAST GROWTH FACTOR 23 predom. Hu WB RD181109100 0.1 mg Rabbit Polyclonal Antibody IgG FGF-23

ANTI-HUMAN VIRUS HEPATITIS B PROTEIN X predom. Hu (virus) WB, IP RD981038100 0.05 mg Rabbit Polyclonal Antibody IgG HBx Protein

ANTI-HUMAN HERSTATIN 2D4 Hu WB RD1820391002D4 0.1 mg Mouse Monoclonal Antibody IgG2a Hst, HER-2 Gene Product

ANTI-HUMAN HERSTATIN 2E9 Hu WB RD1820391002E9 0.1 mg Mouse Monoclonal Antibody IgG2a Hst, HER-2 Gene Product

ANTI-HUMAN HERSTATIN 7H3 Hu WB RD1820391007H3 0.1 mg Mouse Monoclonal Antibody IgG2b Hst, HER-2 Gene Product

ANTI-HUMAN HERSTATIN 10C7 Hu WB, IHC RD182039100C7 0.1 mg Mouse Monoclonal Antibody IgG2a Hst, HER-2 Gene Product

ANTI-HUMAN HERSTATIN predom. Hu WB RD181039050 0.05 mg Rabbit Polyclonal Antibody IgG Hst, HER-2 Gene Product

ANTI-HUMAN INTERLEUKIN-33 predom. Hu WB RD181203100 0.1 mg Rabbit Polyclonal Antibody IgG IL-33, Interleukin-1 family member 11, IL-1F11, Nuclear factor from high endothelial venules, NF-HEV

ANTI-HUMAN INTERLEUKIN-33 predom. Hu WB RD184203100 0.1 mg Sheep Polyclonal Antibody IgG IL-33, Interleukin-1 family member 11, IL-1F11, Nuclear factor from high endothelial venules, NF-HEV

ANTI-HUMAN LEPTIN LEP-02 Hu WB RD182001210-02 0.1 mg Mouse Monoclonal Antibody IgG1 LEP, OB, Obese Protein

ANTI-HUMAN LEPTIN predom. Hu ELISA, WB, RD181001220 0.1 mg Rabbit Polyclonal Antibody IgG IHC, IP LEP, OB, Obese Protein

ANTI-MOUSE LEPTIN predom. Mo ELISA, WB RD281001220 0.1 mg Rabbit Polyclonal Antibody IgG LEP, OB, Obese Protein

ANTI-RAT LEPTIN predom. Rat ELISA, WB RD381001220 0.1 mg Rabbit Polyclonal Antibody IgG LEP, OB, Obese Protein

14 For more information please go to www.biovendor.com ANTIBODIES ANTIBODIES

CLONE/ REACTIVE ISOTYPE SPECIES APPLICATIONS CATALOG NUMBER SIZE

ANTI-HUMAN LEPTIN RECEPTOR LPR-01 Hu ELISA, WB, IHC RD182002110-01 0.1 mg Mouse Monoclonal Antibody IgG1 LEPR, OB-R, CD295

ANTI-HUMAN LEPTIN RECEPTOR LPR-02 Hu ELISA, WB, IHC RD182002110-02 0.1 mg Mouse Monoclonal Antibody IgG1 LEPR, OB-R, CD295

ANTI-HUMAN LIPOCALIN-TYPE predom. Hu ELISA, WB RD181113100 0.1 mg PROSTAGLANDIN-D SYNTHASER IgG Rabbit Polyclonal Antibody BTP, Prostaglandin-H2 D-isomerase, Glutathione-independent PGD synthetase, PGDS2, PGDS, Beta-trace protein, Cerebrin-28, PTGDS, PDS

ANTI-HUMAN LIPOCALIN-TYPE predom. Hu ELISA, WB RD184113100 0.1 mg PROSTAGLANDIN-D SYNTHASER IgG Sheep Polyclonal Antibody BTP, Prostaglandin-H2 D-isomerase, Glutathione-independent PGD synthetase, PGDS2, PGDS, Beta-trace protein, Cerebrin-28, PTGDS, PDS

ANTI-HUMAN MIDKINE predom. Hu ELISA, WB, IHC RD181042050 0.05 mg Rabbit Polyclonal Antibody IgG MK, NEGF-2, Neurite growth promoting factor 2

ANTI-HUMAN MYOSIN LIGHT CHAIN (CARDIAC) predom. Hu WB RD181057050 0.05 mg Rabbit Polyclonal Antibody IgG MLC-I

ANTI-HUMAN MYOSTATIN predom. Hu, Hen, WB RD181005220 0.1 mg Bovine Polyclonal Antibody IgG Turkey GDF-8, Growth Differentiation Factor-8

ANTI-HUMAN MYOSTATIN PROPEPTIDE predom. Hu WB RD183057050 0.05 mg Chicken Polyclonal Antibody IgY GDF-8, Growth Differentiation Factor-8

ANTI-HUMAN MYOSTATIN PROPEPTIDE 4B9 Hu WB, IHC RD1820571004B9 0.1 mg Mouse Monoclonal Antibody IgG2b GDF-8, Growth Differentiation Factor-8

ANTI-HUMAN MYOSTATIN PROPEPTIDE 6E8 Hu WB RD1820571006E8 0.1 mg Mouse Monoclonal Antibody IgG2b GDF-8, Growth Differentiation Factor-8

ANTI-HUMAN NESFATIN-1 predom. Hu ELISA, WB RD184227100 0.1 mg Sheep Polyclonal Antibody IgG Nucleobindin-2, DNA-binding protein NEFA, Gastric cancer antigen Zg4, NUCB2, NEFA

ANTI-HUMAN NEUROGLOBIN predom. Hu, WB, IHC RD181043050 0.05 mg Chicken Polyclonal Antibody IgY Rat, Ngb Dog

ANTI-HUMAN NEUROGLOBIN 13C8 Hu, WB, IHC RD182043100-C8 0.1 mg Mouse Monoclonal Antibody IgG1 Dog Ngb

[email protected] 15 ANTIBODIES S –

O CLONE/ REACTIVE ISOTYPE SPECIES APPLICATIONS CATALOG NUMBER SIZE

ANTI-HUMAN OMENTIN-1 predom. Hu ELISA, WB RD181100100 0.1 mg Rabbit Polyclonal Antibody IgG Intelectin-1, Intestinal lactoferrin receptor, Galactofuranose-binding lectin, Endothelial lectin HL-1

ANTI-HUMAN OMENTIN-1 predom. Hu WB RD184100100 0.1 mg Sheep Polyclonal Antibody IgG Intelectin-1, Intestinal lactoferrin receptor, Galactofuranose-binding lectin, Endothelial lectin HL-1

ANTI-HUMAN OSTEOBLAST SPECIFIC FACTOR 1 predom. Hu WB, IHC RD181044050 0.05 mg Rabbit Polyclonal Antibody IgG Pleiotrophin, OSF-1

ANTI-HUMAN OSTEOBLAST SPECIFIC FACTOR 1 predom. Hu WB RD184044100 0.1 mg Sheep Polyclonal Antibody IgG Pleiotrophin, OSF-1

ANTI-HUMAN OSTEOBLAST SPECIFIC FACTOR 2 predom. Hu, Rat, WB, IHC RD181045050 0.05 mg Rabbit Polyclonal Antibody IgG Hen, Mo Periostin, OSF-2, Fasciclin-I Like

ANTI-HUMAN OSTEOBLAST SPECIFIC FACTOR 2 predom. Hu WB RD184045100 0.1 mg Sheep Polyclonal Antibody IgG Periostin, OSF-2, Fasciclin-I Like

ANTI-HUMAN OSTEOCRIN predom. Hu WB RD181079100 0.1 mg Rabbit Polyclonal Antibody IgG Musclin

ANTI-HUMAN OSTEOPROTEGERIN OPG-01 Hu WB RD182003110-01 0.1 mg Mouse Monoclonal Antibody IgG1 OPG, OCIF, Osteoclastogenesis inhibitory factor

ANTI-HUMAN OSTEOPROTEGERIN OPG-13 Hu WB RD182003110-13 0.1 mg Mouse Monoclonal Antibody IgG1 OPG, OCIF, Osteoclastogenesis inhibitory factor

ANTI-HUMAN PEDF predom. Hu ELISA, WB RD181114100 0.1 mg Rabbit Polyclonal Antibody IgG Pigment epithelium-derived factor, Serpin-F1, EPC-1

ANTI-HUMAN PEDF predom. Hu ELISA, WB RD184114100 0.1 mg Sheep Polyclonal Antibody IgG Pigment epithelium-derived factor, Serpin-F1, EPC-1

ANTI-HUMAN PROCATHEPSIN K predom. Hu WB RD183074100 0.1 mg Chicken Polyclonal Antibody IgY EC 3.4.22.38

ANTI-HUMAN PROCATHEPSIN K 4B9 Hu WB, IHC RD1820741004B9 0.1 mg Mouse Monoclonal Antibody IgG2b EC 3.4.22.38

ANTI-HUMAN PROCATHEPSIN K predom. Hu WB RD181074100 0.1 mg Rabbit Polyclonal Antibody IgG EC 3.4.22.38

16 For more information please go to www.biovendor.com ANTIBODIES ANTIBODIES

CLONE/ REACTIVE ISOTYPE SPECIES APPLICATIONS CATALOG NUMBER SIZE

ANTI-HUMAN PROSTATE-SPECIFIC GENE-1 predom. Hu WB RD181061100 0.1 mg Rabbit Polyclonal Antibody IgG HPG-1

ANTI-HUMAN REGENERATING PROTEIN 1 alpha predom. Hu ELISA, WB, IP, IHC RD181078100 0.1 mg Rabbit Polyclonal Antibody IgG REG 1 alpha, PSP, Lithostatine, PTP

ANTI-HUMAN RELM-beta predom. Hu ELISA, WB RD181047100 0.1 mg Rabbit Polyclonal Antibody IgG Resistin-Like Molecule-beta, FIZZ2

ANTI-HUMAN RESISTIN predom. Hu WB RD184016220 0.1 mg Goat Polyclonal Antibody IgG RSTN, ADSF, FIZZ3

ANTI-HUMAN RESISTIN predom. Hu WB RD181016220 0.1 mg Rabbit Polyclonal Antibody IgG RSTN, ADSF, FIZZ3

ANTI-RAT RESISTIN predom. Rat ELISA, WB RD381016100 0.1 mg Rabbit Polyclonal Antibody IgG RSTN, ADSF, FIZZ3

ANTI-HUMAN S100A6 predom. Hu ELISA, WB RD181215100 0.1 mg Rabbit Polyclonal Antibody IgG S100 calcium-binding protein A11, Protein S100-C, Calgizzarin Metastatic lymph node gene 70 protein, MLN 70, S100A11, MLN70, S100C

ANTI-HUMAN S100A6 predom. Hu ELISA, WB RD184215100 0.1 mg Sheep Polyclonal Antibody IgG S100 calcium-binding protein A11, Protein S100-C, Calgizzarin Metastatic lymph node gene 70 protein, MLN 70, S100A11, MLN70, S100C

ANTI-HUMAN S100A8 predom. Hu WB RD184217100 0.1 mg Sheep Polyclonal Antibody IgG S100 calcium-binding protein A8, Calgranulin-A, Migration inhibitory factor- related protein 8, CFAG, MRP8

ANTI-HUMAN S100A9 predom. Hu ELISA, WB RD184218100 0.1 mg Sheep Polyclonal Antibody IgG S100 calcium-binding protein A9, Calgranulin-B, Migration inhibitory factor-related protein 14, MRP-14, CAGB, CFAG

ANTI-HUMAN S100A10 predom. Hu WB RD184219100 0.1 mg Sheep Polyclonal Antibody IgG S100 calcium-binding protein A10, Calpactin I light chain, p10 protein, p11, Cellular ligand of annexin II, ANX2LG, CAL1L, CLP11

ANTI-HUMAN S100A11 predom. Hu ELISA, WB RD184220100 0.1 mg Sheep Polyclonal Antibody IgG S100 calcium-binding protein A11, Protein S100-C, Calgizzarin Metastatic lymph node gene 70 protein, MLN 70, S100A11, MLN70, S100C

ANTI-HUMAN S100A13 predom. Hu ELISA, WB RD184222100 0.1 mg Sheep Polyclonal Antibody IgG S100 calcium-binding protein A13

[email protected] 17 ANTIBODIES Z –

S CLONE/ REACTIVE ISOTYPE SPECIES APPLICATIONS CATALOG NUMBER SIZE

ANTI-HUMAN S100G predom. Hu ELISA, WB RD184225100 0.1 mg Sheep Polyclonal Antibody IgG S100 calcium-binding protein G, Vitamin D-dependent calcium-binding protein intestinal, CABP, Calbindin-D9k, CABP9K, CALB3, S100D

ANTI-HUMAN SECRETAGOGIN predom. Hu ELISA, WB RD181120100 0.1 mg Rabbit Polyclonal Antibody IgG SCGN, SECRET

ANTI-HUMAN SECRETAGOGIN predom. Hu ELISA, WB RD184120100 0.1 mg Sheep Polyclonal Antibody IgG SCGN, SECRET

ANTI-RAT SECRETAGOGIN predom. Rat WB RD381120100 0.1 mg Rabbit Polyclonal Antibody IgG SCGN, SECRET

ANTI-HUMAN sPLA2-IB predom. Hu WB RD181054100 0.1 mg Rabbit Polyclonal Antibody IgG Secreted Phospholipase A2-IB

ANTI-HUMAN sPLA2-IIA predom. Hu WB RD181055100 0.1 mg Rabbit Polyclonal Antibody IgG Secreted Phospholipase A2-IIA

ANTI-HUMAN sPLA2-IID predom. Hu WB RD181067100 0.1 mg Rabbit Polyclonal Antibody IgG Secreted Phospholipase A2-IID

ANTI-HUMAN sPLA2-IIE predom. Hu WB RD181064100 0.1 mg Rabbit Polyclonal Antibody IgG Secreted Phospholipase A2-IIE

ANTI-HUMAN sPLA2-X predom. Hu WB RD181065100 0.1 mg Rabbit Polyclonal Antibody IgG Secreted Phospholipase A2-X

ANTI-HUMAN sPLA2-XII predom. Hu WB RD181066100 0.1 mg Rabbit Polyclonal Antibody IgG Secreted Phospholipase A2-XII

ANTI-HUMAN sRAGE predom. Hu ELISA, WB RD184116100 0.1 mg Sheep Polyclonal Antibody IgG Soluble Advanced glycation end product-specific receptor

ANTI-HUMAN sRANK predom. Hu WB RD181077100 0.1 mg Rabbit Polyclonal Antibody IgG Soluble RANK Receptor

ANTI-HUMAN STANNIOCALCIN-1 predom. Hu WB RD181095100 0.1 mg Rabbit Polyclonal Antibody IgG STC-1

ANTI-HUMAN sTfR TFR-01 Hu ELISA, WB RD182011110-01 0.1 mg Mouse Monoclonal Antibody IgG1 Soluble Transferrin Receptor, CD71

18 For more information please go to www.biovendor.com ANTIBODIES ANTIBODIES

CLONE/ REACTIVE ISOTYPE SPECIES APPLICATIONS CATALOG NUMBER SIZE

ANTI-HUMAN THYROSTIMULIN BETA SUBUNIT predom. Hu WB RD181106100 0.1 mg Rabbit Polyclonal Antibody IgG GPHB5, TSH

ANTI-HUMAN THYROSTIMULIN BETA SUBUNIT predom. Hu WB RD184106100 0.1 mg Sheep Polyclonal Antibody IgG GPHB5, TSH

ANTI-HUMAN TRAP 5 TRAP-01 Hu EIA RD182025110-01 0.1 mg Mouse Monoclonal Antibody IgG1 Tartrate-Resistant Acid Phosphatase 5, TRACP 5, EC 3.1.3.2

ANIT-HUMAN TREFOIL FACTOR 1 predom. Hu ELISA, WB RD181158100 0.1 mg Rabbit Polyclonal Antibody IgG TFF1, pS2 protein, PNR-2

ANIT-HUMAN TREFOIL FACTOR 1 predom. Hu ELISA, WB RD184158100 0.1 mg Sheep Polyclonal Antibody IgG TFF1, pS2 protein, PNR-2

ANIT-HUMAN TREFOIL FACTOR 2 predom. Hu ELISA, WB RD181159100 0.1 mg Rabbit Polyclonal Antibody IgG Spasmolytic polypeptide, SP, Spasmolysin, TFF2, SML1

ANIT-HUMAN TREFOIL FACTOR 2 predom. Hu ELISA, WB RD184159100 0.1 mg Sheep Polyclonal Antibody IgG Spasmolytic polypeptide, SP, Spasmolysin, TFF2, SML1

ANIT-HUMAN TREFOIL FACTOR 3 predom. Hu ELISA, WB RD181160100 0.1 mg Rabbit Polyclonal Antibody IgG Intestinal trefoil factor, hP1.B, TFF3, hITF, Polypeptide P1.B, ITF, TFI

ANIT-HUMAN TREFOIL FACTOR 3 predom. Hu ELISA, WB RD184160100 0.1 mg Sheep Polyclonal Antibody IgG Intestinal trefoil factor, hP1.B, TFF3, hITF, Polypeptide P1.B, ITF, TFI

ANTI-HUMAN UROMODULIN predom. Hu ELISA, WB, IP RD181163100 0.1 mg Rabbit Polyclonal Antibody IgG Tamm-Horsfall urinary glycoprotein, THP, UMOD

ANTI-HUMAN UROMODULIN predom. Hu ELISA, WB, IP RD184163100 0.1 mg Sheep Polyclonal Antibody IgG Tamm-Horsfall urinary glycoprotein, THP, UMOD

ANTI-HUMAN VISININ LIKE PROTEIN 1 predom. Hu ELISA, WB RD181119100 0.1 mg Rabbit Polyclonal Antibody IgG VILIP, Hippocalcin-like protein 3, HLP3

ANTI-HUMAN VISININ LIKE PROTEIN 1 predom. Hu ELISA, WB RD184119100 0.1 mg Sheep Polyclonal Antibody IgG VILIP, Hippocalcin-like protein 3, HLP3

ANTI-HUMAN ZINC-ALPHA-2-GLYCOPROTEIN predom. Hu ELISA, WB RD181093100 0.1 mg Rabbit Polyclonal Antibody IgG ZA2G, ZAG

[email protected] 19 ANTIBODIES Z CLONE/ REACTIVE ISOTYPE SPECIES APPLICATIONS CATALOG NUMBER SIZE

ANTI-HUMAN ZINC-ALPHA-2-GLYCOPROTEIN predom. Hu ELISA, WB RD184093100 0.1 mg Sheep Polyclonal Antibody IgG ZA2G, ZAG

ANTI-HUMAN ZYMOGEN GRANULE MEMBRANE predom. Hu ELISA, WB RD181229100 0.1 mg PROTEIN 16 IgG Rabbit Polyclonal Antibody Zymogen granule protein 16, hZG16, Secretory lectin ZG16 , ZG16

ANTI-HUMAN ZYMOGEN GRANULE MEMBRANE predom. Hu ELISA, WB RD184229100 0.1 mg PROTEIN 16 IgG Sheep Polyclonal Antibody Zymogen granule protein 16, hZG16, Secretory lectin ZG16 , ZG16

20 For more information please go to www.biovendor.com PROTEINS

Recombinant Proteins

The isolation of many natural proteins at a production scale is ineffective or even impossible for many reasons. The use of modern recombinant protein technologies has overcome many of the limitations and enabled the preparation of a wide range of proteins facilitating research among the scientific community. From among the many production designs, we have chosen to take advantage of the bacterial and mammalian cell expression systems. Special sequences (tags) enabling easy purification and determination are often linked to the C-terminus or N-terminus of the protein sequence. An effective combination of HPLC techniques including ion-exchange chromatography, size exclusion chromatography, Ni-NTA chromatography or antibody immobilized affinity chromatography is used to purify the recombinant proteins. PROTEINS

 HEK293 CELL-EXPRESSED RECOMBINANT PROTEINS Recombinant proteins produced by mammalian HEK293 cells exhibit superior features including their glycosylation pattern and proper folding and subsequent solubility in buffers of physiological pH and ionic strength. As a whole they possess features making them the most similar to natural proteins with respect to their structure, antigenicity and biological activity.

E.COLI -EXPRESSED RECOMBINANT PROTEINS E.coli bacterial expression systems are widely used to produce recombinant proteins easily, quickly, cost effectively and in large quantity. Such is usually the primary method of choice to produce recombinant proteins of small size and unglycosylated proteins. Such proteins often possess antigenicity and biological activity meeting all customer requirements.

ISOLATED NATURAL PROTEINS Human or animal body fluids and tissues are traditional sources of raw materials for the isolation of proteins occurring in concentrations high enough to make their isolation possible and effective. Using deliberately selected, sophisticated purification methods, isolated proteins maintain most of their natural biological functions. HPLC techniques, ion-exchange chromatography, size exclusion chromatography or affinity chromatography are all employed.

[email protected] 21 PROTEINS

FEATURES Formulation All proteins are shipped as lyophilized materials. The proteins are 0.4 μm filtered prior to lyophilization. The buffer used as a lyophilization medium is specified in the corresponding product datasheet. No antimicrobial agents are added. No inert carrier proteins are added.

Reconstitution Follow instructions as described in the product datasheet referring to a particular protein, otherwise precipitation, denaturation or degradation of the protein may occur. Read the product datasheet carefully prior to beginning your work with the protein.

Storage Store the lyophilized proteins at –20 °C. Stability and storage of reconstituted protein is specified in the corresponding product datasheet. A

Quality Control Test Protein content determination: Protein concentration determined by BCA method using BSA as a calibrator Protein purity determination: SDS PAGE (typically 12% PAGE, reduction buffer, 5 μg/lane) Protein identity confirmation: Western blotting using anti-tag- and anti-protein-sequence detection antibodies

Biological Activity We make every effort to test our proteins for their in vitro and/or in vivo biological activity. Protein related sheets are periodically updated. Please contact us to obtain the latest up-to-date data.

Sequence Amino acid sequences of the expressed recombinant proteins are described in this catalog. The extra amino acid residues (e.g. tag sequences) added to the protein‘s own sequence are underlined.

22 For more information please go to www.biovendor.com PROTEINS

HUMAN ADIPOCYTE FABP TAG FREE Recombinant Protein

Other names AFABP, FABP4, Adipocyte Fatty Acid Binding Protein Cat. No. RD172036100 Size 0.1 mg Source E. coli Application ELISA. WB

HUMAN ADIPOCYTE FABP Native Protein PROTEINS Other names AFABP, FABP4, Adipocyte Fatty Acid Binding Protein Cat. No. RD165036050 Size 0.05 mg Source Human adipose tissue Application Cell culture and/or animal studies, ELISA, WB, immunological methods

HUMAN ADIPONECTIN Recombinant Protein

Other names Acrp30, GBP28, AdipoQ Cat. No. RD172023010 Size 0.01 mg Cat. No. RD172023100 Size 0.1 mg Source HEK293 Application ELISA, WB, Cell culture and/or animal studies Activity Effect on gluconeogenesis in primary rat hepatocytes. Effect on macrophage scavenger receptor A (SRA) expression in THP1-derived macrophages.

HUMAN ADIPONECTIN Recombinant Protein

Other names Acrp30, GBP28, AdipoQ Cat. No. RD172029100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN ADIPONECTIN TAG FREE HMW-rich, Recombinant Protein

Other names Acrp30, GBP28, AdipoQ Cat. No. RD172023100-C Size 0.1 mg Source HEK293 Application ELISA, WB, Cell culture and/or animal studies

HUMAN SERUM ADIPONECTIN Native Protein

Other names Acrp30, GBP28, AdipoQ Cat. No. RD162023050 Size 0.05 mg Source Human pooled serum Application ELISA, WB, Cell culture and/or animal studies, Immunological methods

[email protected] 23 PROTEINS

HUMAN ADIPONECTIN (TRIMERIC FORM) Recombinant Protein

Other names Acrp30, GBP28, AdipoQ Cat. No. RD172091100 Size 0.1 mg Source HEK293 Application ELISA, WB, In vitro, ex vivo and in vivo activity analysis, binding assay et al. Activity Inhibition of proliferation of HASMCs. Effect on HB EGF- and PDGF BB-induced smooth muscle proliferation.

HUMAN GLOBULAR ADIPONECTIN Recombinant Protein

Other names gAcrp30, GBP28, AdipoQ Cat. No. RD172112100 Size 0.1 mg

A Source E. coli Application ELISA, WB, In vitro, ex vivo and in vivo activity analysis, binding assay et al.

MOUSE ADIPONECTIN (TRIMERIC FORM) Recombinant Protein

Other names Acrp30, GBP28, AdipoQ Cat. No. RD272091100 Size 0.1 mg Source HEK293 Application ELISA, WB, In vitro, ex vivo and in vivo activity analysis, binding assay et al. Activity Inhibition of proliferation of HASMCs. Effect on HB EGF- and PDGF BB-induced smooth muscle proliferation.

MOUSE ADIPONECTIN Recombinant Protein

Other names Acrp30, GBP28, AdipoQ Cat. No. RD272023100 Size 0.1 mg Source HEK293 Application ELISA, WB, Cell culture and/or animal studies Activity Effect on gluconeogenesis in primary rat hepatocytes. The glucose-lowering effect on C57 mice.

PORCINE ADIPONECTIN Recombinant Protein

Other names Acrp30, GBP28, AdipoQ Cat. No. RD572023100 Size 0.1 mg Source HEK293 Application ELISA, WB, Cell culture and/or animal studies

HUMAN ADIPOPHILIN Recombinant Protein

Other names Adipose differentiation-related protein, ADRP, ADFP Cat. No. RD172161100 Size 0.1 mg Source E. coli Application WB

24 For more information please go to www.biovendor.com PROTEINS

HUMAN ADROPIN Recombinant Protein

Other names Energy homeostasis-associated protein, ENHO, C9orf165 Cat. No. RD172274100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN AGOUTI–RELATED PROTEIN Recombinant Protein PROTEINS Other names AGRP, AGRT, ART Cat. No. RD172030100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN ALLOGRAFT INFLAMMATORY FACTOR-1 Recombinant Protein

Other names AIF-1, Ionized calcium-binding adapter molecule 1, Protein G1 Cat. No. RD172204100 Size 0.1 mg Source E. coli Application WB

HUMAN ALPHA-1-ACID GLYCOPROTEIN Native Protein

Other names AGP1, Orosomucoid-1, OMD1, ORM1 Cat. No. RD162340500 Size 0.5 mg Human pooled serum (All blood samples used for protein preparation were tested and found negative for HBsAg, anti-HCV, HIV Ag/Ab, Source and syphilis.) Application Cell culture and/or animal studies, ELISA, Immunological methods, WB Activity

HUMAN ALPHA-DYSTROGLYCAN N-TERMINAL DOMAIN Recombinant Protein

Other names Dystrophin-associated glycoprotein 1, DAG1, alpha-DG-N Cat. No. RD172318100 Size 0.1 mg Source E. coli Application ELISA, WB Activity

HUMAN ANGIOPOIETIN-LIKE PROTEIN 2 Recombinant Protein

Other names Angiopoietin-Related Protein 2, ANGPTL2, ARP2, UNQ170/PRO196 Cat. No. RD172305100 Size 0.1 mg Source E. coli Application ELISA, WB Activity [email protected] 25 PROTEINS

HUMAN ANGIOPOIETIN-LIKE PROTEIN 3 Recombinant Protein

Other names ANGPTL3 Cat. No. RD172092100 Size 0.1 mg Source E. coli Application ELISA, WB, Biologically active protein Activity Increase of serum cholesterol in C57BL/6J mice. Ingrease of serum triglycerides in C57BL/6J mice.

HUMAN ANGIOPOIETIN-LIKE PROTEIN 3 Recombinant Protein

Other names Angiopoietin-related protein 3, Angiopoietin-5, ANG-5, ANGPT5, UNQ153/PRO179, ANGPTL-3 Cat. No. RD172092050-HEK Size 0.05 mg

A Source HEK293 Application ELISA, WB, Cell culture and/or animal studies Activity

HUMAN ANGIOPOIETIN-LIKE PROTEIN 4 Recombinant Protein

Other names ANGPTL4, FIAF Cat. No. RD172073100 Size 0.1 mg Source E. coli Application ELISA, WB, Biologically active protein Activity Increase of serum cholesterol in C57BL/6J mice. Ingrease of serum triglycerides in C57BL/6J mice.

HUMAN ANGIOPOIETIN-LIKE PROTEIN 4 Recombinant Protein

Other names ANGPTL4, Hepatic fibrinogen/angiopoietin-related protein, HFARP Cat. No. RD172073100-HEK Size 0.1 mg Source HEK293 Application ELISA, WB, Cell culture and/or animal studies

HUMAN ANGIOPOIETIN-LIKE PROTEIN 6 Recombinant Protein

Other names Angiopoietin-related protein 6,Angiopoietin-related growth factor,Angiopoietin-related protein 5 Cat. No. RD172306100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN ANGIOTENSINOGEN Recombinant Protein

AGT; Serpin A8; Serpin Peptidase Inhibitor, Clade A, Member 8; ANHU; Pre-Angiotensinogen; Angiotensin I; Angiotensin II; Alpha-1 Anti- Other names proteinase, Antitrypsin; Serine (Or Cysteine) Proteinase Inhibitor Cat. No. RD172367100 Size 0.1 mg Source HEK293 Application ELISA, WB, Cell culture and/or animal studies

26 For more information please go to www.biovendor.com PROTEINS

HUMAN ANNEXIN A1 Recombinant Protein

Annexin I, Annexin-1, Calpactin II, Calpactin-2, Chromobindin-9, Lipocortin I, Phospholipase A2 inhibitory protein, p35, ANXA1, ANX1, Other names LPC1 Cat. No. RD172371100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN ANNEXIN A2 Recombinant Protein PROTEINS Annexin II, Annexin-2, Calpactin I heavy chain, Calpactin-1 heavy chain, Chromobindin-8, Lipocortin II, Placental anticoagulant protein Other names IV, PAP-IV, Protein I, p36, ANXA2, ANX2, ANX2L4, CAL1H, LPC2D Cat. No. RD172348100 Size 0.1 mg Source E. coli Application ELISA, WB Activity

HUMAN ANNEXIN A2 Native Protein

Annexin II, Annexin-2, Calpactin I heavy chain, Calpactin-1 heavy chain, Chromobindin-8, Lipocortin II, Placental anticoagulant protein Other names IV, PAP-IV, Protein I, p36, ANX2, ANX2L4, CAL1H, LPC2D Cat. No. RD165348040 Size 0.04 mg Source Human Adipose Tissue Application Cell culture and/or animal studies, ELISA, Immunological methods, WB

HUMAN APOLIPOPROTEIN A5 Recombinant Protein

Other names ApoA5, ApoA-V, Regeneration-associated protein 3, RAP3 Cat. No. RD172101100 Size 0.1 mg Source HEK293 Application ELISA, WB, Cell culture or animal studies

HUMAN APOLIPOPROTEIN D Recombinant Protein

Other names ApoD Cat. No. RD172118100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN APOLIPOPROTEIN D Recombinant Protein

Other names ApoD Cat. No. RD172118100-HEK Size 0.1 mg Source HEK293 Application ELISA, WB, Cell culture and/or animal studies

[email protected] 27 PROTEINS

HUMAN APOLIPOPROTEIN M Recombinant Protein

Other names Apo-M, Protein G3a, G3A, NG20 Cat. No. RD172129100 Size 0.1 mg Source HEK293 Application ELISA, WB, Cell culture and/or animal studies

HUMAN BETA-MICROSEMINOPROTEIN Recombinant Protein

Other names Prostate secreted seminal plasma protein, Prostate secretory protein PSP94, PSP-94, IGBF, PN44 Cat. No. RD172140100 Size 0.1 mg C

– Source E. coli

A Application WB

HUMAN BETATROPHIN Recombinant Protein

Other names RIFL, Hepatocellular carcinoma-associated protein TD26, C19orf80, UNQ599/PRO1185, Lipasin, Angiopoietin-like protein 8 Cat. No. RD172347100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN BILE SALT-ACTIVATED LIPASE Native Protein

BAL, Bile salt-stimulated lipase, BSSL, Bucelipase, Carboxyl ester lipase, Cholesterol esterase, Pancreatic lysophospholipase, Sterol Other names esterase, CEL Cat. No. RD166341050 Size 0.05 mg Source Human breast milk Application Cell culture and/or animal studies, ELISA, Immunological methods, WB

HUMAN BRAIN FABP Recombinant Protein

Other names FABP7, Brain lipid-binding protein, BLBP, Brain-type fatty acid-binding protein, B-FABP, Fatty acid-binding protein 7, Mammary-derived growth inhibitor related, BLBP, FABPB, MRG Cat. No. RD172249100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN CARDIOTROPHIN-1 Recombinant Protein

Other names CT-1 Cat. No. RD172026100 Size 0.1 mg Source E. coli Application ELISA, WB

28 For more information please go to www.biovendor.com PROTEINS

HUMAN CARTILAGE OLIGOMERIC MATRIX PROTEIN Recombinant Protein

Other names COMP, Thrombospondin-5, TSP5 Cat. No. RD172080100 Size 0.1 mg Source HEK293 Application ELISA, WB, Cell culture and/or animal studies

HUMAN CARTILAGE OLIGOMERIC MATRIX PROTEIN Recombinant Protein PROTEINS Other names COMP, Thrombospondin-5, TSP5 Cat. No. RGB002 Size 0.1 mg Source CHO Application Drug discovery, In vitro diagnostic

HUMAN CCL2 (MCP-1) Recombinant Protein

Other names C-C motif chemokine 2, HC11, Monocyte chemoattractant protein 1, Monocyte chemotactic and activating factor, MCAF, Monocyte chemotactic protein 1, MCP-1, Monocyte secretory protein JE, Small-inducible cytokine A2, CCl2, MCP1, SCYA2 Cat. No. RD172386050 Size 0.05 mg Source E. coli Application ELISA, WB, Cell culture and/or animal studies, Biologically active protein, Binding assay

HUMAN CCL3 (MIP-1α) Recombinant Protein Other names "C-C motif chemokine 3, G0/G1 switch regulatory protein 19-1, Macrophage inflammatory protein 1-alpha, PAT 464.1, SIS-beta, Small-inducible cytokine A3, Tonsillar lymphocyte LD78 alpha protein, G0S19-1, MIP1A, SCYA3, CCL3" Cat. No. RD172389050 Size 0.05 mg Source E. coli Application ELISA, WB, Cell culture and/or animal studies, Biologically active protein, Binding assay

HUMAN CCL5 (RANTES) Recombinant Protein

Other names EoCP, Eosinophil chemotactic cytokine, SIS-delta, Small-inducible cytokine A5, T cell-specific protein P228, TCP228, T-cell-specific protein RANTES, CCL5, C-C motif chemokine 5 Cat. No. RD172382050 Size 0.05 mg Source E. coli Application ELISA, WB, Cell culture and/or animal studies, Biologically active protein, Binding assay

HUMAN CCL7 (MCP-3) Recombinant Protein

Other names C-C motif chemokine 7, Monocyte chemoattractant protein 3, Monocyte chemotactic protein 3,MCP-3, NC28, Small-inducible cytokine A7, CCL7, MCP3, SCYA6, SCYA7 Cat. No. RD172387050 Size 0.05 mg Source E. coli Application ELISA, WB, Cell culture and/or animal studies, Biologically active protein, Binding assay [email protected] 29 PROTEINS

HUMAN CCL7 (MCP-3) (BIOTINYLATED) Recombinant Protein

Other names C-C motif chemokine 7, Monocyte chemoattractant protein 3, Monocyte chemotactic protein 3,MCP-3, NC28, Small-inducible cytokine A7, CCL7, MCP3, SCYA6, SCYA7 Cat. No. RD172387050-BIOTIN Size 0.05 mg Source E. coli Application ELISA, WB, Cell culture and/or animal studies, Biologically active protein, Binding assay, Immunocytochemistry, Flow cytometry

HUMAN CCL19 (MIP-3β) Recombinant Protein Other names Beta-chemokine exodus-3, CK beta-11, Epstein-Barr virus-induced molecule 1 ligand chemokine, EBI1 ligand chemokine,ELC, Macrophage inflammatory protein 3 beta, MIP-3-beta, Small-inducible cytokine A19 , C-C motif chemokine 19 Cat. No. RD172385050 Size 0.05 mg C Source E. coli Application ELISA, WB, Cell culture and/or animal studies, Biologically active protein, Binding assay

HUMAN CCL27 (CTACK) Recombinant Protein

Other names CC chemokine ILC, Cutaneous T-cell-attracting chemokine, CTACK, Eskine, IL-11 R-alpha-locus chemokine, Skinkine, Small-inducible cytokine A27, C-C motif chemokine 27 Cat. No. RD172384050 Size 0.05 mg Source E. coli Application ELISA, WB, Cell culture and/or animal studies, Biologically active protein, Binding assay

HUMAN CCL28 (MEC) Recombinant Protein

Other names Mucosae-associated epithelial chemokine,MEC, Protein CCK1, Small-inducible cytokine A28, CCL28, C-C motif chemokine 28 Cat. No. RD172383050 Size 0.05 mg Source E. coli Application ELISA, WB, Cell culture and/or animal studies, Biologically active protein, Binding assay

HUMAN CD5 ANTIGEN-LIKE Recombinant Protein

Other names Apoptosis inhibitor expressed by macrophages, CT-2, IgM-associated peptide, SP-alpha, CD5L, API6, UNQ203/PRO229 Cat. No. RD172328100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN CLARA CELL PROTEIN Recombinant Protein

Other names CC16, CC10, Uteroglobin, Urinary protein 1, Clara cell secretory protein Cat. No. RD172022100 Size 0.1 mg Source E. coli Application ELISA, WB

30 For more information please go to www.biovendor.com PROTEINS

HUMAN CLAUDIN-4 Recombinant Protein

Other names Clostridium perfringens enterotoxin receptor, CPE-R, CPE-receptor, Williams-Beuren syndrome chromosomal region 8 protein, CLDN4, CPER, CPETR1, WBSCR8 Cat. No. RD172237100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN CLUSTERIN Native Protein PROTEINS Other names Apolipoprotein J, Apo J Cat. No. RD172034100-S Size 0.1 mg Source Plasma Application ELISA, WB, Cell culture and/or animal studies Activity Inhibition of proliferation of HASMCs. Effect on HB EGF- and PDGF BB-induced smooth muscle proliferation.

HUMAN CLUSTERIN Recombinant Protein

Other names Apolipoprotein J, Apo J Cat. No. RD172034100 Size 0.1 mg Cat. No. RD172034020 Size 0.02 mg Source HEK293 Application ELISA, WB, Cell culture and/or animal studies

CANINE CLUSTERIN Recombinant Protein

Other names Apolipoprotein J, Apo J Cat. No. RD472034100 Size 0.1 mg Source E. coli Application WB

CANINE CLUSTERIN Recombinant Protein

Other names Apolipoprotein J, Apo J Cat. No. RD472034100-HEK Size 0.1 mg Source HEK293 Application ELISA, WB, Cell culture and/or animal studies

RAT CLUSTERIN Recombinant Protein

Other names Apolipoprotein J, Apo J Cat. No. RD372034100 Size 0.1 mg Source E. coli Application ELISA, WB

[email protected] 31 PROTEINS

HUMAN COLLECTRIN Recombinant Protein

Other names TMEM27, UNQ679/PRO1312 Cat. No. RD172266100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN CONNECTIVE TISSUE GROWTH FACTOR Recombinant Protein

Other names CTGF, Hypertrophic chondrocyte-specific protein 24 Cat. No. RD172035100 Size 0.1 mg

C Source E. coli Application WB, Cell culture and/or animal studies

HUMAN CONNECTIVE TISSUE GROWTH FACTOR Recombinant Protein

Other names CTGF, Hypertrophic chondrocyte-specific protein 24 Cat. No. RD172035020-HEK Size 0.02 mg Source HEK293 Application ELISA, WB, Cell culture and/or animal studies

HUMAN CORNIFIN-B Recombinant Protein

Other names SPRR1B, 14.9 kDa pancornulin, Small proline-rich protein IB, SPR-IB Cat. No. RD172320100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN CORTICOTROPIN-RELEASING FACTOR-BINDING Recombinant Protein

Other names CRF-binding protein, Corticotropin-releasing hormone-binding protein, CRHBP, CRFBP Cat. No. RD172151100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN CTRP1 Recombinant Protein

Other names Complement C1q tumor necrosis factor-related protein 1, GIP, G protein-coupled receptor-interacting protein Cat. No. RD172153100 Size 0.1 mg Source E. coli Application ELISA, WB

32 For more information please go to www.biovendor.com PROTEINS

HUMAN CTRP2 Recombinant Protein

Other names Complement C1q tumor necrosis factor-related protein 2, C1QTNF2 Cat. No. RD172154100 Size 0.1 mg Source E. coli Application WB

HUMAN CTRP3 Recombinant Protein PROTEINS Other names Complement C1q tumor necrosis factor-related protein 3, CORS26 Cat. No. RD172121100 Size 0.1 mg Source E. coli Application WB

HUMAN CTRP6 Recombinant Protein

Other names Complement C1q tumor necrosis factor-related protein 6 Cat. No. RD172156100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN CTRP7 Recombinant Protein

Other names Complement C1q tumor necrosis factor-related protein 7 Cat. No. RD172157100 Size 0.1 mg Source E. coli Application WB

HUMAN CTRP8 Recombinant Protein

Other names Complement C1q tumor necrosis factor-related protein 8 Cat. No. RD172179100 Size 0.1 mg Source E. coli Application WB

HUMAN CTRP9A Recombinant Protein

Other names Complement C1q tumor necrosis factor-related protein 9A Cat. No. RD172180100 Size 0.1 mg Source E. coli Application WB

[email protected] 33 PROTEINS

HUMAN CXCL8 (IL-8) Recombinant Protein

Interleukin-8, IL-8, C-X-C motif chemokine 8, Emoctakin, Granulocyte chemotactic protein 1, GCP-1, Monocyte-derived neutrophil Other names chemotactic factor, MDNCF,Monocyte-derived neutrophil-activating peptide, MONAP, Neutrophil-activating protein 1, NAP-1, Protein 3-10C, T-cell chemotactic factor Cat. No. RD172388050 Size 0.05 mg Source E. coli Application ELISA, WB, Cell culture and/or animal studies,Biologically active protein, Binding assay

HUMAN CXCL12 (SDF-1α) Recombinant Protein Stromal cell-derived factor 1, SDF-1a, C-X-C motif chemokine 12, Pre-B cell growth-stimulating factor, PBSF, hIRH, CXCL12 (isoform Other names alpha)

D Cat. No. RD172381050 Size 0.05 mg – Source E. coli C Application ELISA, WB, Cell culture and/or animal studies, Biologically active protein, Binding assay

HUMAN CXCL12 (SDF-1α) (BIOTINYLATED) Recombinant Protein

Stromal cell-derived factor 1, SDF-1a, C-X-C motif chemokine 12, Pre-B cell growth-stimulating factor, PBSF, hIRH, CXCL12 (isoform Other names alpha) Cat. No. RD172381050-BIOTIN Size 0.05 mg Source E. coli Application ELISA, WB, Cell culture and/or animal studies, Biologically active protein, Binding assay, Immunocytochemistry, Flow cytometry

CANINE CYCLOPHILIN A Recombinant Protein

Other names Peptidyl-prolyl cis-trans isomerase A, PPIase A, Cyclosporin A-binding protein, Rotamase A, PPIA, CYPA Cat. No. RD172329100 Size 0.1 mg Source E. coli Application ELISA, WB

CANINE CYSTATIN C Recombinant Protein

Other names Post G-globulin, CST3 Cat. No. RD472009100 Size 0.1 mg Source E. coli Application WB

HUMAN CYSTATIN C Native Protein

Other names Post G-globulin, CST3 Cat. No. RD172009100 Size 0.1 mg Source Human urine Application ELISA, WB

34 For more information please go to www.biovendor.com PROTEINS

HUMAN CYSTATIN C Recombinant Protein

Other names Post G-globulin, CST 3 Cat. No. RD172009100-H Size 0.1 mg Source E. coli Application ELISA, WB

MOUSE CYSTATIN C Recombinant Protein PROTEINS Other names Post G-globulin, CST 3 Cat. No. RD272009100 Size 0.1 mg Source E. coli Application WB

RAT CYSTATIN C Recombinant Protein

Other names Post G-globulin, CST 3 Cat. No. RD372009100 Size 0.1 mg Source E. coli Application WB

HUMAN CYSTEINE-RICH SECRETORY PROTEIN 1 Recombinant Protein

Other names CRISP-1, AEG-like protein, ARP, Acidic epididymal glycoprotein homolog, AEGL1 Cat. No. RD172260100 Size 0.1 mg Source E. coli Application Biologically active protein

HUMAN CYTOKINE-LIKE PROTEIN 1 Recombinant Protein

Other names CYTL1, C4orf4, UNQ1942/PRO4425 Cat. No. RD172265100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN DECORIN Recombinant Protein

Other names Bone proteoglycan II, PG-S2, PG40, DCN, SLRR1B Cat. No. RD172324100 Size 0.1 mg Source E. coli Application ELISA, WB

[email protected] 35 PROTEINS

HUMAN DIPEPTIDYL PEPTIDASE IV Native Protein

Other names DPIV Cat. No. RD172141010mU Size 10 mU Source Human placenta Application Biologically active protein

HUMAN ENPP1 PROTEIN Recombinant Protein

Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, E-NPP 1, Membrane component chromosome 6 surface marker Other names 1, Phosphodiesterase I/nucleotide pyrophosphatase 1, NPP-1, Plasma-cell membrane glycoprotein, PC-1

F Cat. No. RD172124100 Size 0.1 mg –

D Source HEK293 Application ELISA, WB, Cell culture and/or animal studies

HUMAN EPIDERMAL FABP TAG FREE Recombinant Protein

Other names EFABP, FABP5, Epidermal Fatty Acid Binding Protein Cat. No. RD172060100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN FAM3A Recombinant Protein

Other names Cytokine-lie protein 2-19 Cat. No. RD172301100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN FAM3B Recombinant Protein

Other names PANDER, Cytokine-like protein 2-21, Pancreatic-derived factor, C21orf11, C21orf76, PRED44, UNQ320/PRO365 Cat. No. RD172259100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN FAM3C Recombinant Protein

Other names Interleukin-like EMT inducer, FAM3CILEI, GS3786 Cat. No. RD172302100 Size 0.1 mg Source E. coli Application ELISA, WB

36 For more information please go to www.biovendor.com PROTEINS

HUMAN FAM3D Recombinant Protein

Other names UNQ567/PRO1130 Cat. No. RD172303100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN FATTY ACID BINDING PROTEIN 12 Recombinant Protein PROTEINS Other names FABP12 Cat. No. RD172252100 Size 0.1 mg Source E. coli Application ELISA, WB, Immunoassays

HUMAN FETUIN-A (AHSG) Native Protein

Other names Alpha-2-HS-glycoprotein, Ba-alpha-2-glycoprotein, Alpha-2-Z-globulin, Fetuin A, AHSG, FETUA, PRO2743 Cat. No. RD172037100 Size 0.1 mg Source Human plasma Application ELISA, WB, Cell culture and/or animal studies

HUMAN FETUIN-B Recombinant Protein

Other names 16G2, Fetuin-like protein IRL685, Gugu Cat. No. RD172172100 Size 0.1 mg Source HEK293 Application ELISA, WB, Cell culture and/or animal studies

MOUSE FIBROBLAST GROWTH FACTOR 15 Recombinant Protein

Other names FGF-15 Cat. No. RD272184100 Size 0.1 mg Source E. coli Application WB

HUMAN FIBROBLAST GROWTH FACTOR 19 Recombinant Protein

Other names FGF-19 Cat. No. RD172107100 Size 0.1 mg Source E. coli Application ELISA, WB

[email protected] 37 PROTEINS

HUMAN FIBROBLAST GROWTH FACTOR 21 Recombinant Protein

Other names FGF-21 Cat. No. RD172108100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN FIBROBLAST GROWTH FACTOR 21 TAG FREE Recombinant Protein Other names FGF-21 Cat. No. RD172108100-B Size 0.1 mg G Source E. coli –

F Application ELISA, WB

MOUSE FIBROBLAST GROWTH FACTOR 21 Recombinant Protein

Other names FGF-21 Cat. No. RD272108100 Size 0.1 mg Source E. coli Application ELISA, WB

MOUSE FIBROBLAST GROWTH FACTOR 21 TAG FREE Recombinant Protein

Other names FGF-21 Cat. No. RD272108100-B Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN FIBROBLAST GROWTH FACTOR 23 C-TERMINAL PEPTIDE Recombinant Protein

Other names Phosphatonin, Tumor-derived hypophosphatemia-inducing factor, FGF-23, HYPF, UNQ3027/PRO9828 Cat. No. RD172241100 Size 0.1 mg Source E. coli Application WB

HUMAN FOLLISTATIN Recombinant Protein

Other names FS, Activin-binding protein, FST Cat. No. RD172168100 Size 0.1 mg Source E. coli Application ELISA, WB

38 For more information please go to www.biovendor.com PROTEINS

HUMAN GALACTOSIDASE-BINDING SOLUBLE LECTIN 13 Recombinant Protein

Other names Galectin-13, Gal-13, Placental tissue protein 13, PP13, Placental protein 13, LGALS13, PLAC8 Cat. No. RD172254100 Size 0.1 mg Source E. coli Application ELISA, WB, Immunoassays

HUMAN GAMMA ENOLASE Recombinant Protein PROTEINS Other names 2-phospho-D-glycerate hydro-lyase, Enolase 2, Neural enolase, Neuron-specific enolase Cat. No. RGB004 Size 0.1 mg Source HeLa, COS7 Application In vitro diagnostic

HUMAN GANGLIOSIDE GM2 ACTIVATOR Recombinant Protein

Other names Cerebroside sulfate activator protein, GM2-AP, Shingolipid activator protein 3, SAP-3, GM2AP Cat. No. RD172309100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN GASTROKINE-1 Recombinant Protein

Other names 18 kDa antrum mucosa protein, AMP-18, CA11, GKN1, AMP18, UNQ489/PRO1005 Cat. No. RD172268100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN GASTROKINE-2 Recombinant Protein

Other names Blottin, GKN2, BLOT, GDDR, TFIZ1, UNQ465/PRO813 Cat. No. RD172269100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN GASTROTROPIN Recombinant Protein

FABP6, GT, Fatty acid-binding protein 6, Ileal lipid-binding protein, ILBP, Intestinal 15 kDa protein, I-15P, Intestinal bile acid-binding Other names protein, I-BABP, ILBP, ILLBP Cat. No. RD172248100 Size 0.1 mg Source E. coli Application ELISA, WB [email protected] 39 PROTEINS

HUMAN GHRELIN ACYLATED (GHRELIN-28) Synthetic Peptide

Other names Ghrelin-28, Obestatin Cat. No. RD172062100 Size 0.1 mg Source Synthetic peptide Application Biologically active protein, ELISA, WB

HUMAN GLP-1/GLUCAGON-LIKE PEPTIDE-1 Synthetic Peptide

Other names GLP-1 Cat. No. RD172176100 Size 0.1 mg H

– Source Synthetic peptide

G Application Not tested

HUMAN GLUCAGON-LIKE PEPTIDE-1 RECEPTOR Recombinant Protein

Other names GLP-1R Cat. No. RD172243100 Size 0.1 mg Source E. coli Application WB

HUMAN GP96 (TRA1) Recombinant Protein

Endoplasmin; Heat shock protein 90 kDa beta member 1; HSP90B1; 94 kDa glucose-regulated protein; GRP-94; Tumor rejection anti- Other names gen 1; TRA1; gp96 homolog; ECGP; Endothelial cell (HBMEC) glycoprotein Cat. No. RD172379100 Size 0.1 mg Source HEK293 Application ELISA, WB

HUMAN GRANULYSIN Recombinant Protein

Other names Lymphokine LAG-2, T-cell activation protein 519, GNLY, LAG2, NKG5, TLA519 Cat. No. RD172327100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN GROWTH DIFFERENTIATION FACTOR-3 Recombinant Protein

Other names GDF-3 Cat. No. RD172202100 Size 0.1 mg Source E. coli Application WB

40 For more information please go to www.biovendor.com PROTEINS

HUMAN GRP-78 Recombinant Protein

Other names 78 kDa glucose-regulated protein, Heat shock 70 kDa protein 5, Immunoglobulin heavy chain-binding protein, BiP, Endoplasmic reticu- lum lumenal Ca(2+)-binding protein grp78, HSPA5 Cat. No. RD172230100 Size 0.1 mg Source E. coli Application WB

HUMAN HEART FABP Recombinant Protein PROTEINS Other names FABP3, Fatty acid-binding protein 3, H-FABP, Mammary-derived growth inhibitor, MDGI, Muscle fatty acid-binding protein, M-FABP, FABP11 Cat. No. RD172247100 Size 0.1 mg Source E. coli Application WB

HUMAN HEAT SHOCK 10 kDa PROTEIN, MITOCHONDRIAL Recombinant Protein

Other names Hsp10, 10 kDa chaperonin, Chaperonin 10, CPN10, Early-pregnancy factor, EPF, HSPE1 Cat. No. RD172263100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN HEAT SHOCK 70 kDa PROTEIN 1A/1B Recombinant Protein

Other names Heat shock 70 kDa protein 1/2, HSP70-1/HSP70-2, HSPA1A, HSPA1, HSPA1B Cat. No. RD172271100 Size 0.1 mg Source E. coli Application ELISA, Immunoassays, WB

VIRUS HEPATITIS B PROTEIN X Recombinant Protein

Other names HBx Cat. No. RD972038100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN HERSTATIN TAG FREE Recombinant Protein

Cat. No. RD172039100 Size 0.1 mg Source E. coli Application ELISA, WB

[email protected] 41 PROTEINS

HUMAN HIGH MOBILITY GROUP PROTEIN B1 Recombinant Protein

Other names High mobility group protein 1, HMG-1, HMGB1, HMG1 Cat. No. RD172232100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN HIV-1 PROTEASE Active protein

Cat. No. RH1P0001 Size 100 μg in 400 μl Source E. coli

–L Application Crystallography, Inhibitor screening, Kinetic studies H

HUMAN HIV-2 PROTEASE Active protein

Cat. No. RH2P0001 Size 100 μg in 400 μl Source E. coli Application Crystallography, Inhibitor screening, Kinetic studies

HUMAN HSP90 CO-CHAPERONE CDC37 Recombinant Protein

Other names Hsp90 chaperone protein kinase-targeting subunit, p50Cdc37, CDC37, CDC37A Cat. No. RD172226100 Size 0.1 mg Source E. coli Application WB

HUMAN INSULIN RECEPTOR Recombinant Protein

Other names INSR Protein, IR, short isoform (HIR-A, IR-A), CD220 Cat. No. RD172041050 Size 0.05 mg Source HEK293 Application ELISA, WB, Cell culture and/or animal studies

HUMAN INTERLEUKIN-6 Recombinant Protein

Other names IL-6, Interferon-beta 2, B-cell stimulatory factor 2 Cat. No. RD172015100 Size 0.1 mg Source E. coli Application WB

42 For more information please go to www.biovendor.com PROTEINS

HUMAN INTERLEUKIN-33 Recombinant Protein

Other names IL-33, Interleukin-1 family member 11, IL-1F11, Nuclear factor from high endothelial venules, NF-HEV Cat. No. RD172203100 Size 0.1 mg Source E. coli Application WB

HUMAN INTESTINAL FABP Recombinant Protein PROTEINS Other names Fatty acid-binding protein 2, Intestinal-type fatty acid-binding protein, I-FABP, FABP2, FABPI Cat. No. RD172246100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN IRISIN Recombinant Protein

Other names Fibronectin type III domain-containing protein 5,Fibronectin type III repeat-containing protein 2 Cat. No. RD172359100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN KLOTHO Recombinant Protein

Other names KL Cat. No. RD172099100 Size 0.1 mg Source CHO Application ELISA, Immunoassays, WB, Cell culture and/or animal studies

HUMAN LACTOFERRIN Native Protein

Other names Lactotransferrin, Talactoferrin Cat. No. RD1663441000 Size 1 mg Source Human breast milk Application Cell culture and/or animal studies, ELISA, Immunological methods, WB

HUMAN LACTOFERRIN Native Protein

Other names Lactotransferrin, Talactoferrin Cat. No. RD164334050 Size 0.05 mg Source Human seminal plasma Application ELISA, WB, Cell culture and/or animal studies, Immunological methods [email protected] 43 PROTEINS

HUMAN LECITHIN-CHOLESTEROL ACYLTRANSFERASE Recombinant Protein

Other names LCAT, Phosphatidylcholine-sterol acyltransferase, Phospholipid-cholesterol acyltransferase Cat. No. RD172122100 Size 0.1 mg Source E. coli Application WB

HUMAN LECITHIN-CHOLESTEROL ACYLTRANSFERASE Recombinant Protein

Other names LCAT, Phosphatidylcholine-sterol acyltransferase, Phospholipid-cholesterol acyltransferase Cat. No. RD172122100-HEK Size 0.1 mg

L Source HEK293 Application ELISA, WB, Cell culture and/or animal studies

HUMAN LEPTIN TAG FREE Recombinant Protein

Other names LEP, OB, Obese protein Cat. No. RD172001100 Size 0.1 mg Source E. coli Application ELISA, WB

MOUSE LEPTIN TAG FREE Recombinant Protein

Other names LEP, OB, Obese protein Cat. No. RD272001100 Size 0.1 mg Source E. coli Application ELISA, WB

RAT LEPTIN TAG FREE Recombinant Protein

Other names LEP, OB, Obese protein Cat. No. RD372001100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN SERUM LEUCINE-RICH ALPHA-2-GLYCOPROTEIN Native Protein

Other names LRG Cat. No. RD162183100 Size 0.1 mg Source Human pooled serum Application ELISA, WB, Cell culture and/or animal studies, Immunological methods

44 For more information please go to www.biovendor.com PROTEINS

CANINE LEUCINE-RICH ALPHA-2-GLYCOPROTEIN Native Protein

Other names LRG Cat. No. RD462183050 Size 0.05 mg Source Canine pooled serum Application ELISA, WB, Immunological methods, Cell culture and/or animal studies

HUMAN LIPOCALIN-2/NGAL Recombinant Protein PROTEINS Other names 24p3, MSFI, LCN2 Cat. No. RD172102050 Size 0.05 mg Source E. coli Application Biological tests, ELISA, WB

HUMAN LIPOPROTEIN LIPASE Recombinant Protein

Other names LPL, LIPD Cat. No. RD172131100 Size 0.1 mg Source E. coli Application WB

HUMAN LIPOPROTEIN LIPASE Recombinant Protein

Other names LPL, LIPD Cat. No. RD172131100-HEK Size 0.1 mg Source HEK293 Application ELISA, WB, Cell culture and/or animal studies

HUMAN LIVER FABP Recombinant Protein

Other names L-FABP, Fatty acid-binding protein 1, FABP1, FABPL Cat. No. RD172240100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN LIVER FABP TAG FREE Recombinant Protein

Other names L-FABP, Fatty acid-binding protein 1, FABP1, FABPL Cat. No. RD172240101 Size 0.1 mg Source E. coli Application ELISA, WB

[email protected] 45 PROTEINS

PHOTINUS PYRALIS LUCIFERIN 4-MONOOXYGENASE Recombinant Protein

Other names Luciferase Cat. No. RGB005 Size 1×107 RLU Source E. coli Application Bioluminiscence reaction, diagnostic

HUMAN MAMMAGLOBIN A Recombinant Protein

Other names Mammaglobin-1, Secretoglobin family 2A member 2, SCGB2A2, MGB1, UGB2 Cat. No. RD172188100 Size 0.1 mg

–N Source E. coli

L Application ELISA, WB

HUMAN MIDKINE Recombinant Protein

Other names MK, NEGF-2, Neurite growth promoting factor 2 Cat. No. RD172042100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN MYELIN FABP Recombinant Protein

Other names Myelin Fatty acid binding protein, M-FABP, My-FABP, FABP-8, Myelin P2 Protein, PMP2 Cat. No. RD172250100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN MYOSTATIN Recombinant Protein

Other names GDF-8, Growth differentiation factor-8 Cat. No. RD172005300 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN MYOSTATIN PROPEPTIDE TAG FREE Recombinant Protein

Other names GDF-8, Growth differentitation factor-8 Cat. No. RD172058100 Size 0.1 mg Source E. coli Application ELISA, WB

46 For more information please go to www.biovendor.com PROTEINS

HUMAN NESFATIN-1 Recombinant Protein

Other names Nucleobindin-2, DNA-binding protein NEFA, Gastric cancer antigen Zg4, NUCB2, NEFA Cat. No. RD172227100 Size 0.1 mg Source E. coli Application WB

HUMAN NEUDESIN Recombinant Protein PROTEINS Cell immortalization-related protein 2, Neuron-derived neurotrophic factor, Secreted protein of unknown function, SPUF protein, NENF, Other names CIR2, SPUF Cat. No. RD172276100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN NEURITIN Recombinant Protein

Other names NRN1, NRN Cat. No. RD172358100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN NEUROGLOBIN TAG FREE Recombinant Protein

Other names Ngb Cat. No. RD172043100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN NEUROSERPIN Recombinant Protein

Other names Peptidase inhibitor 12, PI-12, Serpin I1, SERPINI1, PI12 Cat. No. RD172326100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN NKG2D LIGAND 1 Recombinant Protein

Other names N2DL-1, NKG2DL1, ALCAN-beta, Retinoic acid early transcript 1I, UL16-binding protein 1, ULBP1, N2DL1, RAET1I Cat. No. RD172311100 Size 0.1 mg Source E. coli Application ELISA, WB

[email protected] 47 PROTEINS

HUMAN NKG2D LIGAND 2 Recombinant Protein

Other names N2DL-2, NKG2DL2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2, ULBP2, N2DL2, RAET1H, UNQ463/PRO791 Cat. No. RD172312100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN NKG2D LIGAND 3 Recombinant Protein

Other names N2DL-3,NKG2DL3, ALCAN-gamma, Retinoic acid early transcript 1N Cat. No. RD172313100 Size 0.1 mg

–P Source E. coli

N Application ELISA, WB

HUMAN OMENTIN Recombinant Protein

Other names Intelectin-1, Intestinal lactoferrin receptor, Galactofuranose-binding lectin, Endothelial lectin HL-1 Cat. No. RD172100100 Size 0.1 mg Source E.coli Application ELISA, WB

HUMAN ONCOMODULIN-1 Recombinant Protein

Other names OM, Parvalbumin beta, OCM, OCM1, OCMN Cat. No. RD172238100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN OSTEOACTIVIN/GPNMB Recombinant Protein

Other names Cat. No. RD172170100 Size 0.1 mg Source HEK293 Application ELISA, WB, Cell culture and/or animal studies

HUMAN OSTEOBLAST SPECIFIC FACTOR 1 Recombinant Protein

Other names OSF-1, Pleiotrophin Cat. No. RD172044100 Size 0.1 mg Source E. coli Application ELISA, WB

48 For more information please go to www.biovendor.com PROTEINS

HUMAN OSTEOBLAST SPECIFIC FACTOR 2 Recombinant Protein

Other names OSF-2, Periostin, Fasciclin-I like Cat. No. RD172045100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN OSTEOCRIN Recombinant Protein PROTEINS Other names Musclin, OSTN Cat. No. RD172079100 Size 0.1 mg Source E. coli Application WB

HUMAN OSTEOSTAT Recombinant Protein

Other names TNFS18, AITR Ligand Cat. No. RD172111100 Size 0.1 mg Source E. coli Application WB

HUMAN PAP-I Recombinant Protein

Other names Pancreatitis-associated Protein-1 Cat. No. RD172085100 Size 0.1 mg Source E. coli Application WB

HUMAN PARAOXONASE 1 Recombinant Protein

Other names Arylesterase 1, PON 1, Aromatic Esterase 1, A-Esterase 1, K-45, Serum Aryldialkylphosphatase 1 Cat. No. RD172279100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN PEDF Recombinant Protein

Other names PEDF, Serpin F1, EPC-1, Cell proliferation-inducing gene 35 protein, PIG35 Cat. No. RD172114100 Size 0.1 mg Source E. coli Application WB

[email protected] 49 PROTEINS

HUMAN PEDF Recombinant Protein

Other names PEDF, Serpin F1, EPC-1, Cell proliferation-inducing gene 35 protein, PIG35 Cat. No. RD172114100-HEK Size 0.1 mg Source HEK293 Application ELISA, WB, Cell culture and/or animal studies

HUMAN PEPTIDASE INHIBITOR 16 Recombinant Protein

Other names PI-16, Cysteine-rich secretory protein 9, CRISP-9, PSP94-binding protein, PSP94-BP, PI16, CRISP9, PSPBP Cat. No. RD172165100 Size 0.1 mg

P Source HEK293 Application ELISA, WB, Cell culture and/or animal studies

HUMAN PEPTIDYL-PROLYL CIS-TRANS ISOMERASE F Recombinant Protein

Other names Mitochondrial, PPIase F, Cyclophilin D, CyP-D, CypD, Cyclophilin F, Mitochondrial cyclophilin, CyP-M, Rotamase F Cat. No. RD172364100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN PEPTIDYL-PROLYL CIS-TRANS ISOMERASE H Recombinant Protein

PPIase H,Rotamase H Small nuclear ribonucleoprotein particle-specific cyclophilin H,CypH U-snRNP-associated cyclophilin SnuCyp-20, Other names USA-CYP Cat. No. RD172366100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN PEPTIDOGLYCAN RECOGNITION PROTEIN 1 Recombinant Protein

Other names PGRP-S, PGLYRP1, TNFSF3L, SBBI68, UNQ639/PRO1269 Cat. No. RD172316100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN PHOSPHO1 Recombinant Protein

Other names Phosphoethanolamine/phosphocholine phosphatase Cat. No. RD172117100 Size 0.1 mg Source E. coli Application WB

50 For more information please go to www.biovendor.com PROTEINS

HUMAN PLATELET GLYCOPROTEIN 4 Recombinant Protein

Fatty acid translocase; FAT; Glycoprotein IIIb; GPIIIB; Leukocyte differentiation antigen CD36; PAS IV; PAS-4; Platelet collagen receptor; Other names Platelet glycoprotein IV; GPIV; Thrombospondin receptor; CD_antigen; CD36 Cat. No. RD172166050 Size 0.05 mg Source HEK293 Application ELISA, WB

HUMAN PROCALCITONIN Recombinant Protein PROTEINS Other names PCT Cat. No. RD172006100 Size 0.1 mg Source E. coli Application WB

HUMAN PROGHRELIN Recombinant Protein

Other names Appetite-regulating hormone, Growth hormone secretagogue, Growth hormone-releasing peptide, Motilin-related peptide, Protein M46 Cat. No. RD172272100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN PROGUANYLIN Recombinant Protein

Cat. No. RD172046100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN PROHIBITIN Recombinant Protein

Other names PHB Cat. No. RD172239100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN PROLACTIN-INDUCIBLE PROTEIN Native Protein

Other names Gross cystic disease fluid protein 15, Prolactin-induced protein, Secretory actin-binding protein, GCDFP15, GPIP4, SABP, GP17, PIP Cat. No. RD164304050 Size 0.05 mg Source Human seminal plasma Application ELISA, WB, Immunological methods, Cell culture and/or animal studies

[email protected] 51 PROTEINS

HUMAN PROLINE-RICH ACIDIC PROTEIN 1 Recombinant Protein

Other names PRAP1, Uterine-specific proline-rich acidic protein, UPA, UNQ608/PRO1195 Cat. No. RD172319100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN PROSTAGLANDIN D SYNTHASE Recombinant Protein

Other names Beta trace protein, Prostaglandin-H2 D-isomerase Cat. No. RD172113100 Size 0.1 mg R

– Source E. coli

P Application WB

HUMAN PROSTATE-SPECIFIC ANTIGEN Native Protein

Other names PSA, Kallikrein-3, Gamma-seminoprotein,P-30 antigen, Semenogelase Cat. No. RD164335050 Size 0.05 mg Source Human seminal plasma Application ELISA, WB, Immunological methods, Cell culture and/or animal studies

HUMAN PROSTATE-SPECIFIC GENE-1 Recombinant Protein

Other names Prostate-Specific Gene-1 Cat. No. RD172061100 Size 0.1 mg Source E. coli Application WB

HUMAN PROTEIN DISULFIDE-ISOMERASE A3 Recombinant Protein

58 kDa glucose-regulated protein, 58 kDa microsomal protein, p58 Disulfide isomerase ER-60, Endoplasmic reticulum resident protein Other names 57, ER protein 57, ERp57 Endoplasmic reticulum resident protein 60,ER protein 60, ERp60 Cat. No. RD172333100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN PROUROGUNAYLIN Recombinant Protein

Guanylate cyclase activator 2B, Guanylate cyclase C-activating peptide 2, Guanylate cyclase C-activating peptide II, GCAP-II, Uroguany- Other names lin, UGN, GUCA2B Cat. No. RD172069100 Size 0.1 mg Source E. coli Application ELISA, WB

52 For more information please go to www.biovendor.com PROTEINS

HUMAN PYRUVATE KINASE M2 Recombinant Protein

Other names Pyruvate kinase isozymes M1/M2, CTHBP, Opa-interacting protein 3, Pyruvate kinase muscle isozyme, THBP1, Tumor M2-PK Cat. No. RD172345100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN REGENERATING PROTEIN 1 ALPHA Recombinant Protein PROTEINS Other names REG 1 alpha, PSP, Lithostatine, PTP Cat. No. RD172078100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN REGENERATING PROTEIN 1 BETA Recombinant Protein

Other names REG 1 beta Cat. No. RD172084100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN REGENERATING PROTEIN 4 Recombinant Protein

Other names REG 4 Cat. No. RD172083100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN REGUCALCIN Recombinant Protein

Other names RC, Gluconolactonase, GNL, Senescence marker protein 30, SMP-30, RGN Cat. No. RD172257100 Size 0.1 mg Source E. coli Application ELISA, WB

MOUSE RELM-ALPHA Recombinant Protein

Other names Resistin-Like Molecule-alpha, FIZZ1 Cat. No. RD272068100 Size 0.1 mg Source E. coli Application WB

[email protected] 53 PROTEINS

HUMAN RELM-BETA Recombinant Protein

Other names Resistin-Like Molecule-beta, FIZZ2 Cat. No. RD172047100 Size 0.1 mg Source E. coli Application WB

MOUSE RELM-GAMMA Recombinant Protein

Other names Resistin-Like Molecule-gamma Cat. No. RD272082100 Size 0.1 mg S

– Source E. coli

R Application WB

MOUSE RENIN RECEPTOR Recombinant Protein

Other names ATPase H(+)-transporting lysosomal accessory protein 2, ER-localized type I transmembrane adaptor, Renin/prorenin Cat. No. RD172264100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN RESISTIN Recombinant Protein

Other names RSTN, FIZZ3, ADSF, Adipose Tissue-Specific Secretory Factor Cat. No. RD172016300 Size 0.1 mg Source E. coli Application WB

HUMAN RESISTIN TAG FREE Recombinant Protein

Other names RSTN, FIZZ3, ADSF, Adipose Tissue-Specific Secretory Factor Cat. No. RD172016301 Size 0.1 mg Source E. coli Application ELISA, WB

MOUSE RESISTIN Recombinant Protein

Other names RSTN, FIZZ3, ADSF, Adipose Tissue-Specific Secretory Factor Cat. No. RD272016300 Size 0.1 mg Source E. coli Application ELISA, WB

54 For more information please go to www.biovendor.com PROTEINS

RAT RESISTIN Recombinant Protein

Other names RSTN, FIZZ3, ADSF, Adipose Tissue-Specific Secretory Factor Cat. No. RD372016300 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN RETINOL BINDING PROTEIN 4 Recombinant Protein PROTEINS Other names RBP4 Cat. No. RD172104100 Size 0.1 mg Source E. coli Application ELISA, WB, Binding assay

HUMAN S100A1 Recombinant Protein

Other names S100 calcium-binding protein A1, S-100 protein subunit alpha, S-100 protein alpha chain, S100A Cat. No. RD172208100 Size 0.1 mg Source E. coli Application WB

HUMAN S100A2 Recombinant Protein

Other names CAN19, S-100L, S100 calcium-binding protein A2, S100L Cat. No. RD172209100 Size 0.1 mg Source E. coli Application WB

HUMAN S100A3 Recombinant Protein

Other names S100 calcium-binding protein A3, Protein S-100E Cat. No. RD172210100 Size 0.1 mg Source E. coli Application WB

HUMAN S100A4 Recombinant Protein

Other names Calvasculin, Metastasin, Placental calcium-binding protein, S100 calcium-binding protein A4, CAPL, MTS1 Cat. No. RD172211100 Size 0.1 mg Source E. coli Application WB

[email protected] 55 PROTEINS

HUMAN S100A5 Recombinant Protein

Other names S100 calcium-binding protein A5, Protein S-100D Cat. No. RD172212100 Size 0.1 mg Source E. coli Application WB

HUMAN S100A6 Recombinant Protein

Other names S100 calcium-binding protein A6, Calcyclin, Prolactin receptor-associated protein, Growth factor-inducible protein 2A9 Cat. No. RD172215100 Size 0.1 mg

S Source E. coli Application WB

HUMAN S100A7 Recombinant Protein

Other names S100 calcium-binding protein A7, Psoriasin, PSOR1, S100A7C Cat. No. RD172216100 Size 0.1 mg Source E. coli Application WB

HUMAN S100A7A Recombinant Protein

Other names S100-A15, S100 calcium-binding protein A7A, S100 calcium-binding protein A7-like 1,S100 calcium-binding protein A15 Cat. No. RD172213100 Size 0.1 mg Source E. coli Application WB

HUMAN S100A8 Recombinant Protein

Other names S100 calcium-binding protein A8, Calgranulin-A, Migration inhibitory factor-related protein 8, MRP-8, p8, Cystic fibrosis antigen, CFAG, Leukocyte L1 complex light chain, Calprotectin L1L subunit, Urinary stone protein band A, CAGA, CFAG, MRP8 Cat. No. RD172217100 Size 0.1 mg Source E. coli Application WB

HUMAN S100A9 Recombinant Protein

Other names S100 calcium-binding protein A9, Calgranulin-B, Migration inhibitory factor-related protein 14, MRP-14, p14, Leukocyte L1 complex heavy chain, Calprotectin L1H subunit, CAGB, CFAG, MRP14 Cat. No. RD172218100 Size 0.1 mg Source E. coli Application WB

56 For more information please go to www.biovendor.com PROTEINS

HUMAN S100A10 Recombinant Protein Other names S100 calcium-binding protein A10, Calpactin-1 light chain, Calpactin I light chain, p10 protein, p11, Cellular ligand of annexin II, ANX2LG, CAL1L, CLP11 Cat. No. RD172219100 Size 0.1 mg Source E. coli Application WB

HUMAN S100A11 Recombinant Protein PROTEINS Other names S100 calcium-binding protein A11, Protein S100-C, Calgizzarin Metastatic lymph node gene 70 protein, MLN 70, MLN70, S100C Cat. No. RD172220100 Size 0.1 mg Source E. coli Application WB

HUMAN S100A12 Recombinant Protein

Other names S100 calcium-binding protein A12, Calgranulin-C, CAGC, CGRP, Neutrophil S100 protein, Calcium-binding protein in amniotic fluid 1, CAAF1, p6, Extracellular newly identified, RAGE-binding protein, EN-RAGE Cat. No. RD172221100 Size 0.1 mg Source E. coli Application WB

HUMAN S100A13 Recombinant Protein

Other names S100 calcium-binding protein A13 Cat. No. RD172222100 Size 0.1 mg Source E. coli Application WB

HUMAN S100A14 Recombinant Protein

Other names S100 calcium-binding protein A14, S114, S100A14 Cat. No. RD172223100 Size 0.1 mg Source E. coli Application WB

HUMAN S100A16 Recombinant Protein

Other names S100 calcium-binding protein A16, Protein S100-F, Aging-associated gene 13 protein, S100F, AAG13 Cat. No. RD172224100 Size 0.1 mg Source E. coli Application WB

[email protected] 57 PROTEINS

HUMAN S100G Recombinant Protein

Other names S100 calcium-binding protein G, Vitamin D-dependent calcium-binding protein intestinal, CABP, Calbindin-D9k, S100G, CABP9K, CALB3, S100D Cat. No. RD172225100 Size 0.1 mg Source E. coli Application WB

HUMAN S100P Recombinant Protein

Other names S100 calcium-binding protein P, Protein S100-E, S100E Cat. No. RD172048100 Size 0.1 mg

S Source E. coli Application ELISA, WB

HUMAN SAP PROTEIN Recombinant Protein

Other names Proactivator polypeptide, Prosaposin, PSAP Cat. No. RD172338100 Size 0.1 mg Source HEK293 Application ELISA, WB, Cell culture and/or animal studies

VIRUS SARS-CoV NUCLEOCAPSID PROTEIN Recombinant Protein

Cat. No. RD972052100 Size 0.5 mg Source E. coli Application WB

VIRUS SCLEROSTIN Recombinant Protein

Other names SOST, UNQ2976/PRO7455/PRO7476 Cat. No. RD172244100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN SECRETAGOGIN Recombinant Protein

Other names SCGN, SECRET Cat. No. RD172120100 Size 0.1 mg Source E. coli Application WB

58 For more information please go to www.biovendor.com PROTEINS

RAT SECRETAGOGIN Recombinant Protein

Other names SCGN, SECRET Cat. No. RD372120100 Size 0.1 mg Source E. coli Application WB

HUMAN SECRETOGLOBIN 3A2 Recombinant Protein PROTEINS Other names Secretoglobin family 3A member 2, Pneumo secretory protein 1, PnSP-1, Uteroglobin-related protein 1 Cat. No. RD172373100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN SECRETOGLOBIN FAMILY 1D MEMBER 1 Recombinant Protein

Other names Lipophilin-A, SCGB1D1, LIPHA Cat. No. RD172284100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN SERGLYCIN Recombinant Protein

Other names Hematopoietic proteoglycan core protein, Platelet proteoglycan core protein, P.PG, Secretory granule proteoglycan core protein, SRGN, PRG, PRG1 Cat. No. RD172368100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN SEX HORMONE-BINDING GLOBULIN Recombinant Protein

Other names SHBG, Sex steroid-binding protein, Testis-specific androgen-binding protein, Testosterone-estradiol-binding globulin, Testosterone-estrogen-binding globulin Cat. No. RGB001 Size 0.1 mg Source CHO Application ELISA standard, Standard for Immunoanalytical methods

HUMAN sFRP-4 Recombinant Protein

Other names Secreted Frizzled-Related Protein 4 Cat. No. RD172132100 Size 0.1 mg Source HEK293 Application ELISA, WB, Cell culture and/or animal studies

[email protected] 59 PROTEINS

HUMAN sPLA2-IB Recombinant Protein

Other names Secreted Phospholipase A2-IB Cat. No. RD172055100 Size 0.1 mg Source E. coli Application WB

HUMAN sPLA2-IIA Recombinant Protein

Other names Phospholipase A2-IIA Cat. No. RD172054100 Size 0.1 mg T

– Source E. coli

S Application WB

HUMAN sPLA2-IID Recombinant Protein

Other names Secreted Phospholipase A2-IID Cat. No. RD172067100 Size 0.1 mg Source E. coli Application WB

HUMAN sPLA2-IIE Recombinant Protein

Other names Secreted Phospholipase A2-IIE Cat. No. RD172064100 Size 0.1 mg Source E. coli Application WB

HUMAN sPLA2-V Recombinant Protein

Other names Secreted Phospholipase A2-V Cat. No. RD172081100 Size 0.1 mg Source E. coli Application WB

HUMAN sPLA2-X Recombinant Protein

Other names Secreted Phospholipase A2-X Cat. No. RD172065100 Size 0.1 mg Source E. coli Application WB

60 For more information please go to www.biovendor.com PROTEINS

HUMAN sPLA2-XII Recombinant Protein

Other names Secreted Phospholipase A2-XII Cat. No. RD172066100 Size 0.1 mg Source E. coli Application WB

HUMAN sRAGE Recombinant Protein PROTEINS Other names Advanced glycation end product-specific receptor Cat. No. RD172116100 Size 0.1 mg Source E. coli Application WB

HUMAN sRAGE Recombinant Protein

Other names Advanced glycation end product-specific receptor Cat. No. RD172116100-HEK Size 0.1 mg Source HEK293 Application ELISA, WB, Cell culture and/or animal studies

HUMAN STANNIOCALCIN-1 Recombinant Protein

Other names STC-1 Cat. No. RD172095100 Size 0.1 mg Source HEK293 Application ELISA, WB, Cell culture and/or animal studies

HUMAN STANNIOCALCIN-2 Recombinant Protein

Other names STC-2 Cat. No. RD172096020 Size 0.02 mg Cat. No. RD172096100 Size 0.1 mg Source HEK293 Application ELISA, WB, Cell culture and/or animal studies

HUMAN TESTIS FABP Recombinant Protein

Other names Testis lipid-binding protein, TLBP, Fatty acid-binding protein 9, T-FABP, FABP9 Cat. No. RD172251100 Size 0.1 mg Source E. coli Application ELISA, WB

[email protected] 61 PROTEINS

HUMAN THYROSTIMULIN ALPHA SUBUNIT Recombinant Protein

Other names GPHA2, Glycoprotein hormone beta 5, GPHB5, Thyrostimulin beta subunit, Glycoprotein hormone alpha-2 Cat. No. RD172110100 Size 0.1 mg Source E. coli Application WB

HUMAN THYROSTIMULIN BETA SUBUNIT Recombinant Protein

Other names Glycoprotein hormone beta 5, GPHB5, TSH Cat. No. RD172106100 Size 0.1 mg U

– Source E. coli

T Application WB

HUMAN TREFOIL FACTOR 1 Recombinant Protein

Other names pS2 protein, PNR-2, TFF1 Cat. No. RD172158100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN TREFOIL FACTOR 2 Recombinant Protein

Other names Spasmolytic polypeptide, Spasmolysin, SP, TFF2 Cat. No. RD172159100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN TREFOIL FACTOR 3 Recombinant Protein

Other names Intestinal trefoil factor, hP1.B, TFF3 Cat. No. RD172160100 Size 0.1 mg Source E. coli Application WB

RAT TREFOIL FACTOR 3 Recombinant Protein

Other names TFF3, Intestinal trefoil factor, rP1.B, Polypeptide P1.B, ITF, TFI Cat. No. RD372160100 Size 0.1 mg Source E. coli Application ELISA, WB

62 For more information please go to www.biovendor.com PROTEINS

HUMAN TRYPSIN-1 Recombinant Protein

Other names Immuno reactive trypsinogen, Beta-trypsin, Cationic trypsinogen Cat. No. RGB003 Size 0.1 mg Source CHO Application In vitro diagnostic

HUMAN TUBULIN POLYMERIZATION-PROMOTING PROTEIN Recombinant Protein PROTEINS Other names TPPP, 25 kDa brain-specific protein, TPPP/p25, p24, p25-alpha, TPPP1 Cat. No. RD172310100 Size 0.1 mg Source E. coli Application ELISA, WB

HUMAN TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 12 Recombinant Protein

Other names APO3 ligand; TNF-related weak inducer of apoptosis; TWEAK; TNFSF12; APO3L, DR3LG Cat. No. RD172148025 Size 0.025 mg Source HEK293 Application ELISA, WB

HUMAN ULBP5 Recombinant Protein

Other names Retinoic acid early transcript 1G protein, RAET1G Cat. No. RD172315100 Size 0.1 mg Source E. coli Application ELISA, WB

CANINE UROMODULIN Native Protein

Other names Tamm-Horsfall urinary glycoprotein, THP, UMOD Cat. No. RD463163100 Size 0.1 mg Source Canine urine Application ELISA, WB, Immunological methods, Cell culture and/or animal studies

FELINE UROMODULIN Native Protein

Other names Tamm-Horsfall urinary glycoprotein, THP, UMOD Cat. No. RD663163050 Size 0.05 mg Source Feline urine Application ELISA, WB

[email protected] 63 PROTEINS

HUMAN UROMODULIN Native Protein

Other names Tamm-Horsfall urinary glycoprotein, THP, UMOD Cat. No. RD172163100 Size 0.1 mg Source Human urine Application ELISA, WB

PORCINE UROMODULIN Native Protein

Other names Tamm-Horsfall urinary glycoprotein, THP, UMOD Cat. No. RD563163100 Size 0.1 mg

–Z Source Porcine urine

U Application ELISA, WB

HUMAN VASPIN Recombinant Protein

Other names Serpin A12, Visceral adipose-specific serpin Cat. No. RD172097100 Size 0.1 mg Source E. coli Application WB

HUMAN VISFATIN Recombinant Protein

Other names pre-B cell colony-enhancing factor, PBEF, NAMPT Cat. No. RD172098100 Size 0.1 mg Source E. coli Application WB

HUMAN VISININ-LIKE PROTEIN 1 Recombinant Protein

Other names VILIP, Hippocalcin-like protein 3, HLP3 Cat. No. RD172119100 Size 0.1 mg Source E. coli Application WB

HUMAN WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 2 Recombinant Protein

Other names Epididymal secretory protein E4, Major epididymis-specific protein E4, Putative protease inhibitor WAP5, WFDC2, HE4, WAP5 Cat. No. RD172369100 Size 0.1 mg Source E. coli Application ELISA, WB

64 For more information please go to www.biovendor.com PROTEINS

HUMAN XYLOSYLTRANSFERASE 2 Recombinant Protein

Other names Peptide O-xylosyltransferase 1; Xylosyltransferase II; XT-II; XylT-II; UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase Cat. No. RD172125020 Size 0.02 mg Source HEK293 Application ELISA, WB, Cell culture and/or animal studies

HUMAN ZINC-ALPHA-2-GLYCOPROTEIN Native Protein PROTEINS Other names ZA2G, ZAG, AZGP1 Cat. No. RD162093025 Size 0.025 mg Source Human serum Application ELISA, WB, Immunological methods, Cell culture and/or animal studies

HUMAN ZINC-ALPHA-2-GLYCOPROTEIN Recombinant Protein

Other names ZA2G, ZAG, AZGP1 Cat. No. RD172093100 Size 0.1 mg Source HEK293 Application ELISA, WB, Cell culture and/or animal studies Activity Stimulation of lipolysis in differentiated human SGBS adipocytes.

HUMAN ZYMOGEN GRANULE MEMBRANE PROTEIN 16 Recombinant Protein

Other names Zymogen granule protein 16, hZG16, Secretory lectin ZG16, ZG16 Cat. No. RD172229100 Size 0.1 mg Source E. coli Application ELISA, WB

[email protected] 65

IMMUNOASSAYS

Immunoassays

Enzyme-Linked Immunosorbent Assay (ELISA) combines the specificity of antibodies with the sensitivity of enzyme catalysis-multiplied signal. The ability of the antibodies to recognize individual target molecules and bind them with high affinity is joined with our ability to prepare antibodies of the required characteristics by modern technologies. It makes immunoanalytical or immunodiagnostic methods powerful tools for the determination of specified molecule concentration in very complex biological matrices like serum/plasma, cerebrospinal fluid, bronchoalveolar lavage, urine, breast milk, tissue extracts, cell culture media, etc. The method is characterized by high sample throughput and does not require expensive equipment in the laboratory. BioVendor’s use of modern immunoassay formats has enabled high assay sensitivity, with an emphasis on superior analytical characteristics and user-friendly kit performance.

FEATURES Format Abroad spectrum of ELISA or ELISA-like assay formats is used. You can find a short description in the catalog and a detailed description in the product datasheet for each kit.

Samples Follow instructions for sample collection, preparation and storage as described in the product datasheet referring to a particular kit.

Applications See the product datasheet to learn which of the biological matrices such as serum/plasma, cerebrospinal fluid, bronchoalveolar lavage, urine, breast milk, tissue extracts, cell culture media, etc. were evaluated for a particular kit. IMMUNOASSAYS Specificity We offer ELISAs applicable for samples of human origin as well as the most commonly used animal models (mouse, rat and others). The main application is indicated by a product name. Read the product datasheet referring to a particular kit to find full cross-reactivity data.

67 IMMUNOASSAYS

Storage The kits are typically stored at 2~8 °C, some of them at -20°. Please follow the storage conditions that are indicated on the kit packaging label.

RUO Products intended for research use only.

IVD Some of BioVendor’s ELISA kits are registered to be used as in vitro diagnostic medical devices according to the EU Directive 98/79/EC. Those kits are labeled with IVD CE mark and are approved to be used as in vitro diagnostics in the EU countries or in the countries where this registration is accepted. In the countries where this registration is not valid, the same kits have to be used as Research-Use-Only products. This limitation applies particularly, but not exclusively, to the USA, Canada and Japan.

Quality Control BioVendor’s ELISA kits pass quality control tests and are provided with a Certificate of Analysis.

68 For more information please go to www.biovendor.com IMMUNOASSAYS

HUMAN 2 SCREEN ISLET CELL AUTOANTIBODY ELISA Autoantibodies to pancreatic beta cell antigens are important serological markers of type 1 diabetes mellitus. The antigens recognised by these autoanti- bodies include insulin, glutamic acid decarboxylase (GAD65 kDa isoform) and an islet cell antigen named IA-2 or ICA-512. 2 Screen ELISA allows simulta- neous measurement of GAD and IA- 2 autoantibodies in the same sample.

Cat. No. R2GI/96R RUO Other names 2 Screen, GAD, IA-2 Product category Diabetology, Autoimmunity Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 4 to 450 U/ml Limit of detection 0.17 U/ml Applications serum Sample requirements 50 μl/well Storage/Shipping -20 °C

5α-ANDROSTANE-3α,17β-DIOL GLUCURONIDE ELISA 5α-Androstane-3α,17β-diol glucuronide is a C19 steroid produced mainly as a metabolite of testosterone and dihydrotestosterone (DHT). It is largely produced in target peripheral tissues such as the skin, especially around hair follicles. The stimulation by large amounts of 3α Diol G leads to excessive hair formation, notably where hair is not normally present in women. Diabetic patients under cyclosporine A therapy have shown increased 3α Diol G levels.

Cat. No. RCAN-DG-460R RUO Other names 3α Diol G Product category Steroid hormones IMMUNOASSAYS Assay format Competitive ELISA, Immobilized antigen Calibration range 0.25 to 50 ng/ml Limit of detection 0.1 ng/ml Applications serum Sample requirements 50 μl/well Storage/Shipping 2−8 °C/Wet ice

8-OHDG 8-OHdG is a widely used biomarker for the measurement of endogenous oxidative DNA damage.

HUMAN 8-OHdG CHECK ELISA (MULTISPECIES SPECIFICITY)

Cat. No. RSCN213100R RUO Other names 8-hydroxy-2'-deoxyguanosine, 2'-Deoxy-7,8-dihydro-8-oxoguanosine Product category Oxidative stress, Animal studies Assay format Competitive ELISA, Immobilized antigen Calibration range 0.5 to 200 ng/ml Applications serum, urine, tissue extract, plasma Sample requirements 50 μl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN 8-OHdG CHECK (ULTRASENSITIVE) ELISA (MULTISPECIES SPECIFICITY)

Cat. No. RSCN213101R RUO Other names 8-hydroxy-2'-deoxyguanosine, 2'-Deoxy-7,8-dihydro-8-oxoguanosine Product category Oxidative stress, Animal studies Assay format Competitive ELISA, Immobilized antigen Calibration range 0.125 to 10 ng/ml Applications tissue extract, urine Sample requirements 50 μl/well Storage/Shipping 2–8 °C/Wet ice [email protected] 69 IMMUNOASSAYS

17α-HYDROXYPROGESTERONE ELISA The steroid 17α−OH Progesterone is produced by the adrenal cortex and gonads. The 17α−OHP has little progestational activity, but it is of intense clini- cal interest because it is the immediate precursor to 11-desoxycortisol (Cpd-S). Cpd-S is produced by 21-hydroxylation of 17α−OHP. Measurement of 17α−OHP is a useful indirect indicator of 21–hydroxylase activity. In congenital 21–hydroxylase deficiency, the most common variety of congenital adrenal hyperplasia (CAH), 17α−OHP is secreted in abundant excess. Measurment of 17α−OHP is therefore valuable in the initial diagnosis of CAH.

Cat. No. RCAN-P-320R RUO Other names 17α-OHP Product category Steroid hormones Assay format Competitive ELISA, Immobilized antigen Calibration range 0.15 to 20 ng/ml Limit of detection 0.11 ng/ml Applications serum Sample requirements 50 μl/well Storage/Shipping 2−8 °C/Wet ice

HUMAN 25-OH-VITAMIN D ELISA Vitamin D is a steroid hormone involved in the intestinal absorption of calcium and the regulation of calcium homeostasis. Clinical applications of 25-OH Vitamin D measurements are the diagnosis and therapy control of postmenopausal osteoporosis, rickets, osteomalacia, renal osteodystrophy, pregnancy, neonatal hypocalcemia and hyperparathyro­idism. Vitamin D intoxication mostly occurs during a large intake of pharmaceutical preparations of Vitamin D and may lead to hypercalcemia, hypercalcuria and nephrocalcinosis in susceptible infants.

Cat. No. REA300/96 IVD CE Product category Bone and cartilage metabolism Assay format Competitive ELISA, Immobilized antibody Calibration range 0 to 120 ng/ml Limit of detection 1.9 ng/ml Applications serum, plasma

–A Storage/Shipping 2–8 °C/Wet ice 1

HUMAN s90K/Mac-2BP ELISA 90K/Mac-2 BP (90 kDa) is a human serum glycoprotein, originally identified in the supernatant of human breast cancer cells.Serum levels of 90K/Mac- 2 BP have been determined in patients with various forms of neoplasia and with some viral infections. In breast and colorectal cancer and in non-Hodgkin lymphoma, high levels of 90K/Mac-2 BP are correlated with a poor prognosis. The determination of 90K/Mac-2 BP in the serum can be used as a valu- able parameter for monitoring the outcome of cancer and viral infections.

Cat. No. RBMS234R RUO Other names Galectin-3-binding protein, Mac-2-binding protein, Tumor-associated antigen 90K, Serum protein 90K Product category Immune Response, Infection and Inflammation, Oncology Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 12.5 to 200 ng/ml Limit of detection 0.92 ng/ml Applications serum, plasma, cell culture supernatant Sample requirements 100 µl/well (1:100 prediluted) Storage/Shipping 2–8 °C/Wet ice

70 For more information please go to www.biovendor.com IMMUNOASSAYS

HUMAN ACETYLCHOLINE RECEPTOR AUTOANTIBODY ELISA Autoantibodies to the acetylcholine receptor (AChR) are responsible for failure of the neuromuscular junction in myasthenia gravis. Measurement of these antibodies can be of considerable value in disease diagnosis and management.

Cat. No. RACE/96R RUO Other names AChR Product category Autoimmunity Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.2 to 20 nmol/l Limit of detection 0.23 nmol/l Applications serum Sample requirements 25 μl/well Storage/Shipping -20 °C

ADIPOCYTE FATTY ACID BINDING PROTEIN (AFABP) AFABP, a product of FABP4 gene, is expressed predominantly in adipocytes and macrophages, and is critical in the regulation of the biological function of these cells. In mice, targeted mutations in FABP4 gene provide significant protection from hyperinsulinemia and insulin resistance in the context of both dietary and genetic obesity. AFABP-deficient mice have reduced efficiency of lipolysis in adipocytes and exhibited improved systemic dyslipidemia. In humans, circulating AFABP levels predict the development of the metabolic syndrome, type 2 diabetes mellitus and carotid atherosclerosis. AFABP is increased in metabolic syndrome and discriminates individuals with permanent and temporary body weight loss and might be a prognostic marker of body weight loss suggesting a preventive therapeutic intervention.

HUMAN ADIPOCYTE FABP ELISA IMMUNOASSAYS Cat. No. RD191036200R RUO Other names AFABP, FABP4, Adipocyte Fatty Acid Binding Protein Product category Energy metabolism and body weight regulation, Diabetology Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.5 to 25 ng/ml Limit of detection 0.05 ng/ml Applications serum, plasma Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

MOUSE ADIPOCYTE FABP ELISA

Cat. No. RD291036200R RUO Other names AFABP, FABP4, Adipocyte Fatty Acid Binding Protein Product category Energy metabolism and body weight regulation, Diabetology, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.78 to 50 ng/ml Limit of detection 0.23 ng/ml Applications serum Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

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ADIPONECTIN Adiponectin (244 aa) is expressed in adipose cells. It belongs to the soluble defence collagen superfamily containing collagen VIII a X homologous domain and C1q-like globular domain. Adiponectin forms covalently bound trimers (LMW), 2 trimers form hexamers (MMW) and their multiples (HMW) circulating in blood. The receptors AdipoR1 and AdipoR2 have been identified. Adiponectin increases insulin sensitivity and decreases plasma glucose by increasing tissue fat oxidation. It inhibits the inflammatory processes of atherosclerosis suppressing the expression of adhesion and cytokine molecules in vascular endothelial cells and macrophages. This adipokine plays a role as a scaffold of newly formed collagen in myocardial remodelling after ischaemic injury. Adi- ponectin has become a clinically relevant parameter to be measured in subjects at risk for type 2 diabetes, atherosclerosis and the metabolic syndrome.

HUMAN ADIPONECTIN ELISA

Cat. No. RD195023100 IVD CE Other names Acrp30, AdipoQ, GBP28 Product category Cardiovascular disease, Diabetology, Energy metabolism and body weight regulation Assay format Competitive ELISA, Immobilized antigen Calibration range 0.1 to 10 µg/ml Limit of detection 26 ng/ml Applications serum, plasma Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN ADIPONECTIN ELISA, HIGH SENSITIVITY

Cat. No. RD191023100 IVD CE Other names Acrp30, AdipoQ, GBP28 Product category Cardiovascular disease, Diabetology, Energy metabolism and body weight regulation Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 1 to 150 ng/ml Limit of detection 0.47 ng/ml (serum, plasma), 0.156 ng/ml (milk, urine, CSF) A Applications serum, plasma, breast milk, urine, cerebrospinal fluid (CSF) Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

MOUSE ADIPONECTIN ELISA

Cat. No. RD293023100R RUO Other names Acrp30, AdipoQ, GBP-28 Product category Animal studies, Cardiovascular disease, Diabetology, Energy metabolism and body weight regulation Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.25 to 8 ng/ml Limit of detection 0.079 ng/ml Applications serum, cell culture medium Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

PORCINE ADIPONECTIN ELISA

Cat. No. RD591023200R RUO Other names Acrp30, AdipoQ, GBP28 Product category Animal studies, Cardiovascular disease, Diabetology, Energy metabolism and body weight regulation Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 1 to 100 ng/ml Limit of detection 0.026 ng/ml Applications serum, plasma Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

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HUMAN ADIPONECTIN HMW ELISA

Cat. No. RSCHHMWADN096R RUO Other names Acrp30, AdipoQ, GBP28 Product category Cardiovascular disease, Diabetology, Energy metabolism and body weight regulation Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 3.125 to 200 ng/ml Limit of detection 3.125 to 200 ng/ml Applications serum, plasma (heparin) Sample requirements 10 μl/well Storage/Shipping 2–8 °C/Wet ice

MOUSE/RAT ADIPONECTIN HMW ELISA

Cat. No. RSHAKMAN011R RUO Other names Acrp30, AdipoQ, GBP28 Product category Animal studies, Cardiovascular disease, Diabetology, Energy metabolism and body weight regulation Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 3.13 to 200 ng/ml (In the case of 50X dilution, original HMW adiponectin range is 156 to 10 000 ng/ml) Limit of detection 0.313 ng/ml Applications serum Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice IMMUNOASSAYS

ADMA The vascular endothelium plays a central role in the regulation of vascular structure and function, mainly due to the formation of endothelium-derived nitric oxide (NO). NO is formed by the enzyme NO synthetase (NOS) from the amino acid precursor L-arginine. NOS activity can be downregulated by ADMA, an endogenous inhibitor of NOS. Elevated ADMA levels in plasma have been found in clinical studies including patients with hypercholesterolemia, hyperten- sion, chronic heart failure, chronic renal failure and other internal disorders. ADMA may have diagnostic relevance as a novel cardiovascular risk marker.

ADMA ELISA

Cat. No. REA201/96 IVD CE Other names Asymmetric Dimethylarginine Product category Blood pressure regulation and NO metabolism, Cardiovascular disease Assay format Competitive ELISA, Immobilized antigen Calibration range 0.40 to 0.75 µmol/l Limit of detection 0.05 μmol/l Applications serum, plasma (EDTA) Sample requirements 20 μl Storage/Shipping 2–8 °C/Wet ice

HUMAN ADMA ELISA, HIGH SENSITIVITY

Cat. No. REA209/96R RUO Other names Asymmetric Dimethylarginine Product category Blood pressure regulation and NO metabolism, Cardiovascular disease Assay format Competitive ELISA, Immobilized antigen Limit of detection 0.01 µmol/l Applications cell culture medium, serum, plasma (EDTA, heparin) Sample requirements 5–20 µl Storage/Shipping 2–8 °C/Wet ice

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AGGRECAN ELISA Aggrecan (PG) is the predominant proteoglycan species in articular cartilage. The loss of PG and other matrix components from the cartilage leads to destruction of the tissue, causing complete deterioration of the articular surface. PG and PG fragments released in synovial fluid and serum during this degradation process might serve as markers of the metabolic changes in diseased cartilage.

Cat. No. RIS001R RUO Other names PG Product category Bone and cartilage metabolism Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 10 to 150 ng/ml Limit of detection 0.9 ng/ml Applications serum, synovial fluid Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

ALBUMIN (SERUM ALBUMIN) Serum albumin is the most abundant blood plasma protein and is produced in the liver. It contributes to the maintenance of oncotic pressure as well as to transport of hydrophobic molecules. Low albumin levels in serum can suggest liver or kidneys disease, inflammation, shock, and malnutrition. High albumin levels in serum usually reflects dehydration. Urine albumin indicates renal disorders, low concentrations of albumin in diabetics is now considered very important for predicting later development of diabetic nephropathy.

BOVINE ALBUMIN ELISA

Cat. No. RSHAKRBS018R RUO Product category Animal studies, Renal disease Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.78 to 50 ng/ml Limit of detection 39 pg/ml A Applications serum, plasma, cell culture medium Sample requirements 100 μl/well Storage/Shipping 2–8 °C/Wet ice

MOUSE ALBUMIN ELISA

Cat. No. RSHAKRAL121R RUO Product category Animal studies, Renal disease Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 50 to 1000 ng/ml Limit of detection 2.5 ng/ml Applications serum, plasma, cell culture medium, urine Sample requirements 5 μl/well Storage/Shipping 2–8 °C/Wet ice

RAT ALBUMIN ELISA

Cat. No. RSHAKRAL120R RUO Product category Animal studies, Renal disease Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 50 to 1000 ng/ml Limit of detection 2.5 ng/ml Applications serum, plasma, cell culture medium, urine Sample requirements 5 μl/well Storage/Shipping 2–8 °C/Wet ice

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MOUSE ALBUMIN URINARY (S-TYPE) ELISA

Cat. No. RSHAKRAL021SR RUO Product category Animal studies, Renal disease Assay format Immunoturbidimetry/nephelometry Calibration range 6.17 to 500 μg/ml Applications serum, urine Sample requirements 15 µl/test Storage/Shipping 2–8 °C/Wet ice

RAT ALBUMIN URINARY ASSAY

Cat. No. RSHAKRAL020R RUO Product category Animal studies, Renal disease Assay format Immunoturbidimetry/nephelometry Calibration range 10 to 500 μg/ml Limit of detection 1 μg/ml Applications serum, plasma, urine Storage/Shipping 2–8 °C/Wet ice

RAT ALBUMIN URINARY (S-TYPE) ASSAY

Cat. No. RSHAKRAL-020SR RUO IMMUNOASSAYS Product category Animal studies, Renal disease Assay format Immunoturbidimetry/nephelometry Calibration range 6.17 to 500 μg/ml Applications plasma, serum, urine Sample requirements 7 µl/test Storage/Shipping 2–8 °C/Wet ice

ALDOSTERONE ELISA Aldosterone is a potent mineral corticoid whose synthesis and release are controlled by the renin-angiotensin system of the body. Aldosterone promotes the reabsorption of sodium in the distal tubules of the kidney resulting in potassium secretion along with sodium retention, which controls the circulating blood. Chronic overproduction and secretion of aldosterone leads to hypertension. Measurement of aldosterone levels in serum in conjunction with plasma renin levels can be used to differentiate between primary and secondary aldosteronism.

Cat. No. RCAN-ALD-450R RUO Product category Blood pressure regulation and NO metabolism, Steroid hormones Assay format Competitive ELISA, Immobilized antigen Calibration range 15 to 1000 pg/ml Limit of detection 10 pg/ml Applications serum, plasma, urine Sample requirements 50 μl/well Storage/Shipping 2–8 °C/Wet ice

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HUMAN ALLOGRAFT INFLAMMATORY FACTOR 1 ELISA Human allograft inflammatory factor 1 (AIF-1) is a 17kDa cytoplasm, calcium-binding protein encoded by the AIF1 gene. AIF- 1 plays an important role in vascular inflammation, in anti-inflammatory response to vessel wall trauma via negative regulation of growth of vascular smooth muscle cells, and in immune response and vasculopathy in allografts. AIF-1 was found in both cardiac allografts and hearts with other cardiac cellular diseases. In cardiac allografts, expression levels of AIF-1 in both cardiomyocytes and mononuclear cells directly correlated with the severity of cardiac cellular rejection. AIF-1 expression in transplanted human hearts correlates with rejection and development of coronary artery vasculopathy (CAV). Thus, AIF-1 can be a potential biomarker for cardiac allograft rejection. AIF-1 is crucial for the survival and pro-inflammatory activity of macrophages, the activation and proliferation of T-lymphocytes and enhances lymphocyte migration. In human CAV, AIF-1 is expressed in T-lymphocytes and expression increases when T cells are activated. Increased numbers of AIF-1 immunoreactive macrophages/microglial cells were observed in focal brain infarctions and traumatic brain injury, in inflammatory lesions of a rat model of autoimmune disease and other disorders. AIF-1 is secreted into the blood stream during experimental autoimmune neuritis. Enhanced AIF-1 expression leads to augmented incorporation of degenerated LDL by macrophages and promotes development of atherosclerotic vasculopathy. AIF-1 is also expressed in tissues from patients with systemic sclerosis.

Cat. No. RD191204200R RUO Other names AIF-1, Ionized calcium-binding adapter molecule 1, Protein G1, AIF1, G1, IBA1 Product category Cardiovascular disease, Immune Response, Infection and Inflammation, Transplantation Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 31.3 to 1000 pg/ml Limit of detection 4.0 pg/ml Applications serum, plasma (EDTA, citrate) Sample requirements 20 µl/well Storage/Shipping 2–8 °C/Wet ice

RAT ALPHA-1-ACID GLYCOPROTEIN ELISA Alpha-1 Acidic-Glycoprotein is an acute phase protein, which is nonspecifically increased in plasma during acute inflammation. It becomes a marker of acute and chronic inflammatory diseases and tissue injury.

Cat. No. RSCPRE061R RUO Other names α1-AG , AGP1, Orosomucoid-1, OMD1, ORM1

A Product category Animal studies, Immune Response, Infection and Inflammation, Oncology Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0 to 40 ng/ml Applications serum Sample requirements 20 μl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN ALPHA-1-ANTITRYPSIN IN STOOL ELISA Alpha-1-antitrypsin (α-1-AT) is a 52 kDa glycoprotein, which is produced by the liver, intestinal macrophages, monocytes and mucous membrane cells of the gut. It belongs to the group of acute phase proteins and is one of the most important proteinase inhibitor. α-1-AT inhibits, beside others, the proteinas- es trypsin and the elastase of neutrophiles. A lack of α-1-AT leads to an enhanced proteolysis. Only a very small amount of α-1-AT is cleaved or resorbed in the gut. Therefore the measurement of α-1-AT in stool reflects the permeability of the gut during inflammatory processes.

Cat. No. RIC6200 IVD CE Other names α-1-AT Product category Infection and inflammation, Immune Response Assay format Sandwich ELISA, HRP-labelled antibody Limit of detection 1.5 ng/ml Applications serum, stool Sample requirements 100 µl/well Storage/Shipping 2–8 °C/Wet ice

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HUMAN ALPHA-FETOPROTEIN ELISA Alpha-fetoprotein (AFP) is a glycoprotein with a molecular weight of approximately 70 KD. AFP is normally produced during fetal and neonatal develop- ment by the liver, yolk sac, and in small concentrations by the gastrointestinal tract. After birth, serum AFP concentrations decrease rapidly, and by the second year of life and thereafter only trace amounts are normally detected in serum. Elevation of serum AFP to abnormally high values occurs in several malignant diseases, most notably nonseminomatous testicular cancer and primary hepatocelluar carcinoma. In the case of nonseminomatous testicular cancer, a direct relationship has been observed between the incidence of elevated AFP levels and the stage of disease. Elevated AFP levels have also been observed in patients diagnosed with seminoma with nonseminomatous elements, but not in patients with pure seminoma. In addition, elevated serum AFP concentrations have been measured in patients with other noncancerous diseases, including ataxia telangiectasia, hereditary tyrosinemia, neonatal hyperbilirubinemia, acute viral hepatitis, chronic active hepatitis and cirrhosis. Elevated serum AFP concentrations are also observed in pregnant women. Therefore, AFP measurements are not recommended for use as a screening procedure to detect the presence of cancer in the general population.

Cat. No. RIS0018R RUO Other names AFP Product category Oncology Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 10 to 160 IU/ml Limit of detection 1 IU/ml Applications serum Sample requirements 25 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN ALS ELISA The mature acid-labile subunit (ALS) consists of 578 amino acids and contains about 20 leucin rich sequence repeats.. Together with IGFBP-3 and IG- FBP-5, ALS is able to form the so called ternary complex with IGF and the acid-labile subunit (ALS). In the circulation nearly all IGF is bound in this ternary

complex and thus not able to cross the endothelial barrier. Only very small amounts of IGF or IGFBP-3 exist outside this complex. The acid-labile subunit IMMUNOASSAYS is an important part of the IGF-storage mechanism in circulation. In ALS deficiency or in ALS knock-out mice the concentration of IGF and IGFBP-3 in the circulation is significantly decreased resulting in impaired growth. The determination of the ALS concentration is of use in evaluation of GH-deficiency and excess.

Cat. No. RMEE35R RUO Other names Acid Labile Subunit Product category Growth hormone and factor-related products Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0 to 40 mU/ml Limit of detection 0.23 mU/ml Applications serum, plasma Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

ANDROSTENEDIONE ELISA Androstenedione is produced by the adrenals and gonads. As a result, the determination of the level of androstenedione in serum is important in the evaluation of the functional state of these glands. Androstenedione is a precursor of testosterone and estrone. Besides the adrenals, in females, the ovaries have been shown to be an important source of androstenedione. It has been reported that there is a fluctuation day by day of androstenedione during the ovulatory cycle. The use of serum testosterone determination in conjunction with the enzyme immunoassay of androstenedione can be used to determine if the source of the excess androgen production is adrenal or ovarian.

Cat. No. RCAN-AD-208R RUO Product category Steroid hormones Assay format Competitive ELISA, Immobilized antigen Calibration range 0 to 10 ng/ml Limit of detection 0.05 ng/ml Applications serum Sample requirements 25 μl/well Storage/Shipping 2–8 °C/Wet ice

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ANGIOPOIETIN-LIKE PROTEIN 3 Angptl3 is a 490-amino acid protein, a member of angiopoietin-like family of proteins, its expression is restricted to the liver. Angptl3 and Angptl4 have been shown to regulate fat, lipid or glucose metabolic homeostasis. Angptl3 is a hepatocyte-derived circulating factor that affect lipid metabolism and is involved in regulating lipid storage and breakdown. Angptl3 overexpression or i.v. injection increased circulating plasma lipid levels in mice. Angptl3 decreases VLDL triglyceride clearance by inhibiting lipoprotein lipase (LPL) activity and increase release of free fatty acid and glycerol from adipocytes. Angptl3 in diabetic states might be involved in inducing hypertriglyceridemia and hyperfattyacidemia in diabetes and obesity and might be involved in the pathogenesis of metabolic syndrome. A possible role of Angptl3 in angiogenesis plays a key role in the progression of solid tumor growth, diabetic retinopa- thies, psoriasis, inflammation, and rheumathoid arthritis is studied.

HUMAN ANGIOPOIETIN-LIKE PROTEIN 3 ELISA

Cat. No. RD191092200R RUO Other names ANGPTL3 Product category Energy metabolism and body weight regulation Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 12.5 to 400 ng/ml Limit of detection 1.08 ng/ml Applications serum, plasma Sample requirements 30 μl/well Storage/Shipping 2–8 °C/Wet ice

MOUSE/RAT ANGIOPOIETIN-LIKE PROTEIN 3 ELISA

Cat. No. RAG011R RUO Other names Angiopoietin-related protein 3, Angiopoietin-5, ANG-5, ANGPT5, UNQ153/PRO179, ANGPTL-3 Product category Energy metabolism and body weight regulation, Animal studies Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.016 to 1 ng/ml A Limit of detection 15 pg/ml Applications serum, plasma, cell culture supernatant Storage/Shipping 2–8 °C/Wet ice

HUMAN ANGIOPOIETIN-LIKE PROTEIN 4 ELISA Angiopoietin-like protein 4 (ANGPTL4), also known as HFARP (hepatic fibrinogen/an­giopoietin-related protein), FIAF (fasting-induced adipose factor), and PGAR (PPAR-angiopoietin related), is a secreted 50 kD protein that modulates the disposition of circulating triglycerides by inhibiting lipoprotein lipase (LPL). It is one of the seven members of the angiopoietin-like family. ANGPTL4 is expressed ubiquitously, predominantly in adipose tissue, liver, placenta, myocardium, keratinocytes, podocytes, intestine, and pituitary gland. ANGPTL4 consists of a N-terminal coiled-coil domain converting the active form of LPL into an inactive form and a C-terminal fibrinogen-like domain mediating its antiangiogenic functions. Upon secretion into the circulation, ANGPTL4 is cleaved; the N-terminal peptide circulates as an oligomer, and the C-terminal peptide circulates as a monomer. The N-terminal domain of ANGPTL4 interacts directly with LPL, irreversibly inactivating the enzyme. Cleavage of ANGPTL4 appears to be tissue-dependent in humans; liver secretes cleaved AN- GPTL4, whereas adipose tissue secretes the full-length form. In mice the full-length form of ANGPTL4 is physically associated with HDL, whereas truncated ANGPTL4 is associated with low density lipoprotein. In humans, both full-length and truncated ANGPTL4 are associated with HDL. ANGPTL4 expression is upreguated by fasting, free fatty acids, PPAR agonists, acute phase response, glucocorticoids, and downregulated by insulin. ANGPTL4 has been implicated in cardiovascular disease, cancer metastasis, obesity, diabetes, wound repair, inflammation, arthritis and nephrotic syndrome. ANGPTL4 serum levels dis- play high variability between individuals ranging from 2 to 158 ng/ml. ANGPTL4 correlates positively with age, body fat mass, waist-hip-ratio and free fatty acids but negatively with plasma HDL-cholesterol and do not correlate with triglycerides. ANGPTL4 is a positive acute phase protein and its increase could contribute to the hypertriglyceridemia that characteristically occurs during the acute phase response by inhibiting LPL activity.

Cat. No. RD191073200R RUO Other names Hepatic fibrinogen/angiopoietin-related protein, HFARP, ANGPTL4, ARP4, HFARP, PGAR Product category Energy metabolism and body weight regulation Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.94 to 60 ng/ml Limit of detection 0.173 ng/ml Applications serum, plasma (EDTA citrate) Sample requirements 40 µl/well Storage/Shipping 2–8 °C/Wet ice

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HUMAN ANGIOPOIETIN-LIKE PROTEIN 6 ELISA Seven angiopoietin-like proteins (ANGPTLs) share the char-acteristic protein structure of the angiopoietin family (ANG), but differ in their inability to bind antiopoietin receptor, Tie-2. ANGPTL6 was originally named angiopoietin-related growth factor (AGF) having an N-terminal coiled-coil-like domain and a C- terminal fibrinogen-like domain, both of which are conserved in ANG. It is a circulating protein secreted by liver that induces angiogenesis by direct effect of epidermal ANGPTL6 on endothelial cells and proliferation of skin cells, and thereby promotes wound healing. Oike et al. generated Angptl6 -/- mice, 80% of which died at about embryonic day 13. The surviving null mice developed marked obesity, lipid accumulation in skeletal muscle and liver, and insulin resistance accompanied by reduced energy expenditure relative to controls. Conversely, mice with constitutive overexpression of ANGPTL6 showed leanness and increased insulin sensitivity resulting from increased energy expenditure, and were also protected from high-fat dietinduced obesity, insulin resistance, and nonadipose tissue steatosis. Hepatic overexpression of ANGPTL6 by adenoviral transduction in mice fed a high-fat diet resulted in significant weight loss and increased insulin sensitivity. It was concluded that ANGPTL6 is a hepatocyte-derived circulating factor that counteracts obesity and obesity-related insulin resistance, meaning that ANGPTL6 may be a novel biomarker for metabolic diseases.

Cat. No. RAG001R RUO Other names ANGPTL6 Product category Energy metabolism and body weight regulation Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 1.56 to 100 ng/ml Limit of detection 1.2 ng/ml Applications serum, plasma, cell culture supernatant Sample requirements 60 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN ANGIOPOIETIN-LIKE PROTEIN 7 ELISA The angiopoietins are a family of growth factors that are specific for vascular endothelium or metabolic regulation. A full-length cDNA encoding angiopoi- etin-like protein 7 (ANGPTL7), which is also called cornea-derived transcript 6; CDT6, was isolated from the human cornea. The deduced 346-amino acid ANGPTL7 protein has the characteristic structure of the other ANGPTL family members : a signal peptide, an extended helical domain predicted to form IMMUNOASSAYS dimeric or trimeric coiled-coils, a short linker peptide, and a globular fibrinogen-like domain. Gene expression profile analysis suggests that the cornea is a major organ expressing ANGPTL7 whereas brain, liver or pancreas also express ANGPTL7, suggesting ANGTL7 primailiy plays an important role in eye function and may be also implicated in metabolism. In fact, in the search for genes altered by glaucomatous insults, ANGPTL7 was identified as one of the mostly induced genes. It has been found that overexpression of ANGPTL7 in primary human trabecular meshwork cells altered the expression of fibronec- tin, collagens type I, IV & V, myocilin, versican, and MMP1, suggesting ANGPTL7 may be a causative gene for glaucoma. ANGPTL7 secretion is induced by glaucoma stimuli such as dexamethasone (DEX) or transforming growth factor beta (TGFβ) and its concentration determined by western blot is elevated in glaucomatous aqueous humor, suggesting an important role in glaucoma. ANGPTL7 reduces tumor growth and aberrant blood vessel formation by induc- ing massive fibrosis (4–5) Characterized as potent target gene of the Wnt/β-catenin signaling pathway, it is a pharmacogenomics target in the fields of oncology and regenerative medicine. However, its humoral quantitative levels such as serum, plasma, or glaucomatous aqueous humor are in response to glaucoma, tumors, or metabolic dysfunctions remain unknown but may be interesting to know the status of these diseases.

Cat. No. RAG017R RUO Other names ANGPTL7, Cornea-Derived Transcript 6, CDT6 Product category Oncology, Others Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.063 to 4 ng/ml Limit of detection 30 pg/ml Applications serum, cell culture supernatant Sample requirements 60 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN/RAT ANGIOTENSIN II ELISA Angiotensin II is converted to angiotensin II through removal of two terminal residues by the enzyme (ACE, or kinase). Angiotensin II acts as an endocrine, autocrine/paracrine, and intracrine hormone. It is apart of renin-angiotensin-aldosterone system playing an important role in regulating blood volume and systemic vascular resistance, which together influence cardiac output and arterial pressure. Increased plasma concentrations of angiotension II have been implicated in atherogenesis.

Cat. No. RA05880R RUO Product category Renal disease, Blood pressure regulation and NO metabolism Assay format Sandwich ELISA, AChE-labelled antibody Calibration range 0.98 to 125 pg/ml Limit of detection 0.5–1.5 pg/ml Storage/Shipping –20 °C

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HUMAN ANGIOTENSIN-CONVERTING ENZYME 2 ELISA By EST database searching for sequences showing homology to the zinc metalloprotease angiotensin-I converting enzyme, a full-length ACE2 cDNA, originally called ACEH, was isolated, which encoded a deduced 805-amino acid protein that shares approximately 40% identity with the N- and C-terminal domains of ACE. ACE2 contains a potential 17-amino acid N-terminal signal peptide and a putative 22-amino acid C-terminal membrane anchor. Northern blot analysis detected high expression of ACE2 in kidney, testis, and heart, and moderate expression in colon, small intestine, and ovary. Tipnis et al. expressed a soluble, truncated form of ACE2 lacking transmembrane and cytosolic domains in CHO cells and found that it produced a glycosylated protein that was able to cleave angiotensin I and angiotensin II , but not bradykinin. Boehm and Nabel showed whereas ACE converts angiotensin I to angioten- sin II, which has 8 amino acids, ACE2 converts angiotensin I to angiotensin 1–9, which has 9 amino acids. This can then further be converted by ACE to a shorter peptide, angiotensin 1–7, which is a blood vessel dilator. Using ACE2 null mice, Crackower et al. showed that ACE2 was critically involved in a cardiac contractility. Li et al. identified ACE2, isolated from SARS coronavirus-permissive Vero E6 cells, that efficiently binds the S1 domain of the SARS coronavirus S protein. It was shown that when ACE2 was engaged with S protein ACE2 surface expression was downregulated, increasing lung levels of angiotensin II, which was proposed to give rise to a severe lung injury. Since ACE2 is detected in urine, measurement of shedded ACE2 may provide a novel clue to renal & cardiovascular function of ACE2.

Cat. No. RAG006R RUO Other names ACE2, SARS Receptor Product category Renal disease, Blood pressure regulation and NO metabolism Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.391 to 25 ng/ml Limit of detection 293 pg/ml Applications cell culture supernatant, urine Storage/Shipping 2–8 °C/Wet ice

ANNEXIN V Annexin belongs to calcium-dependent phospholipid-binding proteins. All annexins have been shown to have putative binding site for protein kinases C but only annexin V would possess a potential pseudo-substrate site. Annexin V was found to play a major role in matrix vesicle-initiated cartilage calcification as a collage-regulated calcium channel.

HUMAN ANNEXIN V ELISA A Cat. No. RBMS252R RUO Other names Endonexin II, Calphobindin I, Placental anticoagulant protein I, Thromboplastin inhibitor, Vascular anticoagulant alpha, Anchorin CII, Annexin 5, Placental protein 4 Product category Autoimmunity Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.8 to 50 ng/ml Limit of detection 0.33 ng/ml Applications serum, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN ANTI-ANNEXIN V ELISA

Cat. No. RBMS247R RUO Product category Autoimmunity Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 6.25 to 400 ng/ml Limit of detection 1.18 ng/ml Applications serum, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

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MOUSE ANTI-dsDNA ELISA The quantification of mouse autoantibodies anti-DNP-IgE, anti-OVA-IgE, anti-OVA-IgG1, anti-dsDNA, anti-ssDNA is a tool to research the development and progression of severe autoimmune diseases.

Cat. No. RSHAKRDD061R RUO Other names Anti-double-stranded deoxyribonucleic acid Product category Autoimmunity, Cytokines and chemokines and related molecules, Immune Response, Infection and Inflammation Assay format Direct ELISA, HRP-labelled antibody Calibration range 15.6 to 1000 mU/ml Limit of detection 0.78 mU/ml Applications serum, plasma (EDTA, citrate) Sample requirements 1 μl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN ANTI-IFN-ALPHA ELISA Antibodies to IFN-α were detected in patients with various autoimmune disorders and in the serum of patients with systemic lupus erythematosus. Spon- taneous antibodies to IFN-a were shown to occur in sera of various cancer patients. Neutralizing IFN-α antibodies were also found in cerebrospinal fluids and sera of acute aseptic meningitis patients as well as in patients with chronic polyarthritis.

Cat. No. RBMS217R RUO Other names Anti-alpha interferon, IFN leukocytic, LeIF D Product category Infection and inflammation, Cytokines, chemokines and related molecules, Immune Response, Autoimmunity Assay format Sandwich ELISA, HRP-labelled antibody

Calibration range 3.15 to 200 ng/ml IMMUNOASSAYS Limit of detection 1.4 ng/ml Applications serum, urine, plasma, cell culture supernatant Sample requirements 20 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN ANTI-IgA IgG ELISA Anti-IgA in the IgG class are specific IgG antibodies against immunoglobulin A. Patients with IgA deficiency often demonstrate circulating antibodies against IgA, which have been suggested to be associated with transfusion reactions. Anti-IgA antibodies occur in about 10% of patients with selective IgA deficiency (IgAD) and are detected approximately in the same percentage of patients with Common Variable Immunodeficiency (CVID). Patients with anti- IgA antibodies are at risk to develop an anaphylactoid reaction to substitution gamma globulin treatment, especially upon intravenous administration.

Cat. No. RD199145100R RUO Product category Autoimmunity, Immune Response, Infection and Inflammation, Transplantation Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 1.563 to 100 U/ml Limit of detection 0.712 U/ml Applications serum, plasma Sample requirements 5 μl/well Storage/Shipping 2–8 °C/Wet ice

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KEYHOLE LIMPET HEMOCYANIN (KLH) Keyhole limpet hemocyanin (KLH) is a large cooper-containing protein consisting of subunits with MW of 400 kDa. It is found in the hemolymph of the sea mollusk Megathura crenulata. This extracellular respiratory protein has many immunostimulatory properties, including the ability to enhance the host’s im- mune response by interacting with T cells, monocytes, macrophages, andpolymorpho­nuclear lymphocytes. Since its discovery, KLH has been used primarily as a carrier for vaccines and antigens and as adjuvant treatment in regimens such as antimicrobial therapy.

RAT ANTI-KLH IgG ELISA

Cat. No. RSHAKRKG010R RUO Other names Keyhole limpet hemocyanin Product category Animal studies, Immune Response, Infection and Inflammation Assay format Sandwich ELISA, HRP-labelled antibody Limit of detection 47 pg/ml Applications serum, plasma Sample requirements 50 μl/well Storage/Shipping 2–8 °C/Wet ice

RAT ANTI-KLH IgM ELISA

Cat. No. RSHAKRKM010R RUO Other names Keyhole limpet hemocyanin Product category Animal studies, Immune Response, Infection and Inflammation Assay format Sandwich ELISA, HRP-labelled antibody Limit of detection 313 pg/ml Applications serum, plasma Sample requirements 50 μl/well Storage/Shipping 2–8 °C/Wet ice A

MOUSE ANTI-OVA-IgE ELISA

Cat. No. RSHAKRIE030R RUO Other names Anti-Ovalbumin-IgE Product category Animal studies Assay format Direct ELISA, Biotin-labelled antibody Calibration range 1.88 to 120 U/ml Limit of detection 0.094 U/ml Applications serum, plasma Sample requirements 5 μl/well Storage/Shipping 2–8 °C/Wet ice

MOUSE ANTI-OVA-IgG1 ELISA

Cat. No. RSHAKRIE040R RUO Other names Anti-Ovalbumin-IgG1 Product category Animal studies Assay format Direct ELISA, Biotin-labelled antibody Calibration range 1.88 to 120 U/ml Limit of detection 0.094 U/ml Applications serum, plasma Sample requirements 5 μl/well Storage/Shipping 2–8 °C/Wet ice

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MOUSE ANTI-ssDNA ELISA

Cat. No. RSHAKRSD051R RUO Other names Anti-single-stranded deoxyribonucleic acid Product category Animal studies Assay format Direct ELISA, HRP-labelled antibody Calibration range 15.6 to 1 000 mU/ml Limit of detection 0.78 mU/ml Applications serum, plasma (EDTA, citrate) Sample requirements 1 μl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN sAPO-1/FAS ELISA APO-1/Fas (48 kDa), a member of the TNF/NGF receptor superfamily, is a glycosylated surface protein containing a single transmembrane region. APO-1 is expressed on a variety of human B and T cell lines, on many different tumor cells and on various normal human tissues. The tissue distribution of APO- 1 and of the APO-1 ligand suggests that the APO-1 receptor/ligand system plays an important role in various aspects of mammalian development and especially in the homeostasis of the immune system.

Cat. No. RBMS245R RUO Other names CD95, Fas receptor, APT 1, ALPS 1 A, TNFRSF6 Product category Apoptosis Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 15.6 to 1000 pg/ml Limit of detection 13.2 pg/ml IMMUNOASSAYS Applications serum, cell culture supernatant Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN APOLIPOPROTEIN B-48 ELISA Apolipoprotein B-48 (ApoB-48) is a truncated form of apoB100 produced through post-trasnscriptional editing of the mRNA of apoB100 in the small in- testine. It is the major protein of chylomicrons and chylomicron remnants, which transport endogenous lipid from the liver. Apo B-48 plays an essential role in the intestinal absorption of dietary fats. AapoB-100 and apoB-48 are incompletely understood but are of importance because elevated levels of apoB, the main protein in LDL, are associated with an increased risk of coronary heart disease.

Cat. No. RSHAKHB48R RUO Other names ApoB-48 Product category Lipoprotein metabolism, Cardiovascular disease Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 2.5 to 160 ng/ml Limit of detection 0.198 ng/ml Applications serum, plasma (heparin or EDTA as anticoagulant) Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

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HUMAN APOLIPOPROTEIN D ELISA Apolipoprotein D (ApoD) is a glycoprotein with MW about 29 kDa, which is associated with HDL in plasma. Higher expression was observed in adre- nal glands, pancreas, kidneys, placenta, spleen, lungs, ovaries, testes, brain (astrocytes), peripheral nerves and cerebrospinal fluid. The normal level of plasmatic apoD has been estimated at about 12 mg/100 ml. Different levels of apoD were found in various pathological states, e.g. gross cystic disease, schizophrenia (after treatment with antipsychotic drugs), Nieman-Pick Type C (NPC) disease. Plasma ApoD levels are significantly reduced in patients with Tangier disease and hyperchylomicronemia ApoD may play an important role in oxidative stress. ApoD interacts with the cytoplasmic portion of the long form of leptin receptor, thus it may play a role in the control of food intake and body weight.

Cat. No. RD193118200R RUO Other names ApoD Product category Lipoprotein metabolism, Energy metabolism and body weight regulation Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.16 to 10 ng/ml Limit of detection 0.086 ng/ml Applications serum, plasma, urine, cerebrospinal fluid Sample requirements 20 µl/well Storage/Shipping 2-8 °C/ Wet ice

HUMAN APOLIPOPROTEIN H/BETA2-GP1 ELISA Apoliporotein H (ApoH, Beta-2 Glycoprotein I, Activated protein C-binding protein, Anticardiolipin cofactor or APC inhibitor) is a single chain glycoprotein consisting of 326 amino acid residues that can be divided into five short consensus repeat domains. ApoH has a molecular weight of about 50kDa and is synthesized by hepatocytes and circulates mainly in free form or associated with lipoproteins. ApoH is a major antigen for antiphospholipid antibodies present in patients with antiphospholipid syndrome (APS), which is related to venous and arterial thrombosis, fetal loss, and thrombocytopenia. AapoH may function in blood coagulation and in the clearance of apoptotic bodies from circulation. Serum concentrations of apoH were abnormal in patients with primary hyperlipidaemia. Significant correlations were demonstrated between plasma apoH concentrations and those of triglyceride and total cholesterol. Regarding insulin resistance, serum apoH concentrations are increased in type 2 diabetes patients with microalbuminuria, suggesting a relationship with microvascular complications. ApoH was described as a major urinary protein in the urine of patients with renal tubular disorders such as Wilson´s disease, Dent´s syndrome, Fanconi´s syndrome and renal tubular acidosis.

Cat. No. RD191236100R RUO Other names ApoH, Beta-2 Glycoprotein I, Activated protein C-binding protein –B

A Product category Cardiovascular disease, Diabetology, Lipoprotein metabolism, Renal disease Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 1.25 to 80 ng/ml Limit of detection 0.08 ng/ml Applications serum, plasma, urine Sample requirements 10 µl/well Storage/Shipping 2-8 °C/ Wet ice

HUMAN APOLIPOPROTEIN M ELISA Human Apolipoprotein M (ApoM, protein G3a, NG20-like protein NG20), is encoded by the APOM gene. ApoM is a secreted 25kDa member of the lipocalin protein family consisting of 188 amino acids. The apolipoproteins are a structurally-unrelated group of proteins that all have some role in the transport of lipids in blood. ApoM is exclusively expressed in the hepatocytes and in the renal tubular epithelium. The encoded protein is secreted through the plasma membrane but remains membrane-bound, where it is involved in lipid transport. ApoM was found associated with HDL in human plasma and to a lesser extent with LDL, triglyceride-rich lipoproteins and chylomicrons. Apolipoprotein M plays an important role in the anti-atherogenic function of HDL by influencing the accumulation of cholesterol in these particles and reverse cholesterol transport. ApoM inhibits LDL oxidation and increases the capacity of HDL to induce cholesterol efflux from macrophage foam. Expression of ApoM is regulated by HNF-1a, PAF, TGF, IGF, leptin and leptin receptor. Both, leptin and leptin receptor are essential for ApoM expression. ApoM concentration in plasma is positively related to leptin and negatively related to cholesterol levels in humans. However, the strongest positive correlation was to ApoA1, total cholesterol and LDL cholesterol. Thus, ApoM may play important role in the prevention of atherosclerosis. ApoM may also play a role in host defense response. ApoM concentrations correlated negatively to acute-phase markers HBP (heparin-binding protein), procalcitonin, CRP and IL-6. During sepsis and SIRS, the plasma concentrations of ApoM decrease, the decrease of ApoM could contribute to the increased vascular leakage observed in sepsis and SIRS.

Cat. No. RD191129200R RUO Other names Apo-M, Protein G3a, G3A, NG20 Diabetology, Energy metabolism and body weight regulation, Immune Response, Infection and Inflammation, Lipoprotein Product category metabolism Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.313 to 10 ng/ml Limit of detection 0.067 ng/ml Applications serum, plasma Sample requirements 20 µl/well Storage/Shipping 2-8 °C/ Wet ice

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HUMAN APRIL ELISA APRIL is a member of the tumor necrosis factor family. APRIL appears to play a role in T-independent type II antigen responses and T cell survival, but can also induce proliferation/sur­vival of nonlymphoid cells. Local production of APRIL was found in arthritic joints of patients with inflammatory arthritis.

Cat. No. RBMS2008R RUO Other names TNF 13, TALL 2, TRDL 1, CD256 antigen Product category Cytokines, chemokines and related molecules, Apoptosis Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.78 to 50 ng/ml Limit of detection 0.4 ng/ml Applications serum, plasma, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN AQUAPORIN-4 AUTOANTIBODY ELISA

Cat. No. RAQP4/96/2R RUO Other names AQP4 Ab Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 1.5 to 80 units/Ml Limit of detection 0.17 units/mL Applications serum Sample requirements 50 μL IMMUNOASSAYS Storage/Shipping 2–8 °C/Wet ice

HUMAN ARGINASE LIVER TYPE ELISA Arginase is an enzyme that hydrolyzes L-arginine to L-ornithine and urea in the urea cycle. Liver-type arginase I (35 kDa), a protein circulating in blood probably as a homotrimer, is expressed in the liver and to some extend in the erythrocytes. It was clinically used as a liver specific marker which may reflect not only early occurence of liver injury but also early termination of liver injury. The measurement of liver-type arginase is clinically applicable for monitoring conditions of patients with liver disorders or pre- and postoperative conditions of patients who received partial hepatectomy. It plays important roles in autoimmune inflammation in the CNS.

Cat. No. RD193028000 RUO Other names EC 3.5.3.1, L-arginine aminohydrolase Product category Blood pressure regulation and NO metabolism Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 5 to 320 ng/ml Limit of detection 0.5 ng/ml Applications serum, cerebrospinal fluid Sample requirements 25 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN Bcl-2 ELISA Bcl-2 initiates a new gene family involved in the regulation of cell death and survival without affecting cell proliferation. Bcl-2 protein plays a critical role in oncogenesis as well as resistance to therapy for cancer.

Cat. No. RBMS224/3R RUO Other names Apoptosis regulator Bcl 2 Product category Apoptosis Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.5 to 32 ng/ml Limit of detection 0.5 ng/ml Applications serum, plasma, cell culture lysate Sample requirements 20 µl/well Storage/Shipping 2–8 °C/Wet ice [email protected] 85 IMMUNOASSAYS

BETA2-MICROGLOBULIN β2-microglobulin is a protein found on the surface of many cells. Testing is primarily done when evaluating a person for certain kinds of cancer affecting white blood cells including chronic lymphocytic leukemia, non-Hodgkin‘s lymphoma, and multiple myeloma or kidney disease.

HUMAN BETA2-MICROGLOBULIN ELISA

Cat. No. RCAN-B-4300R RUO Product category Renal disease Assay format Competitive ELISA, Immobilized antigen Calibration range 0.2 to 10 mg/l Limit of detection 0.1 mg/l Applications serum Sample requirements 20 µl/well Storage/Shipping 2–8 °C/Wet ice

RAT BETA2-MICROGLOBULIN ELISA

Cat. No. RSCPRH111R RUO Product category Renal disease, Animal studies Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.31 to 10 ng/ml Applications serum, plasma, urine Sample requirements 10 μl/well Storage/Shipping 2–10 °C/Wet ice

C-PEPTIDE –C Insulin is synthesized in the beta-cells of the islets of Langerhans as a precursor molecule, proinsulin. In the secretory granules of the beta-cells, proinsulin B is cleaved into insulin and into a 31-amino-acid peptide, called the Connecting Peptide or C-Peptide. Insulin and C-Peptide are secreted in equimolar amounts. However, because of its longer half-life, the plasma concentration of C-peptide is higher than that of insulin. The determination of plasma C-Pep- tide allows an assessment of the endogenous insulin production, even in the presence of exogenous insulin administration or in the presence of circulating anti-insulin antibodies. Moreover, the determination of C-Peptide in urine provides a reliable index of the insulin production when blood sampling is difficult or when an integrated estimation of C-Peptide secretion over a period of several hours is requested.

HUMAN C-PEPTIDE ELISA

Cat. No. RIS005R RUO Product category Animal studies, Diabetology Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.05 to 4.9 pmol/ml Limit of detection 0.01 pmol/ml Applications serum Sample requirements 100 µl/well Storage/Shipping 2–8 °C/Wet ice

MOUSE C-PEPTIDE (U-TYPE) ELISA

Cat. No. RSHAKRCP031R RUO Product category Diabetology, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 30 to 3 000 pg/ml Limit of detection 1.5 pg/ml Applications serum, plasma, cell culture medium Sample requirements 10 μl/well Storage/Shipping 2–8 °C/Wet ice

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RAT C-PEPTIDE (U-TYPE) ELISA

Cat. No. RSHAKRCP030R RUO Product category Diabetology, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 30 to 3 000 pg/ml Limit of detection 1.5 pg/ml Applications serum, plasma, cell culture medium Sample requirements 10 μl/well Storage/Shipping 2–8 °C/Wet ice

C-REACTIVE PROTEIN C-reactive protein is a plasma protein, a member of the pentraxin family of proteins. It is synthesized in the liver following tissue damage caused by inflam- mation, infection, or trauma. CRP is considered to be an important acute phase marker in such conditions.

CANINE C-REACTIVE PROTEIN ELISA, HIGH SENSITIVITY

Cat. No. RH931CRP01DCR RUO Other names CRP Product category Animal studies, Immune Response, Infection and Inflammation, Sepsis Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 1.5 to 40.0 µg/ml Limit of detection 3.6 ng/ml IMMUNOASSAYS Applications serum Sample requirements 5 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN C-REACTIVE PROTEIN ELISA

Cat. No. RAP001 IVD CE Other names CRP Product category Immune Response, Infection and Inflammation, Sepsis Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0 to 100 μg/ml Limit of detection 1 μg/ml Applications serum, plasma Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN C-REACTIVE PROTEIN ELISA, HIGH SENSITIVITY

Cat. No. RAP002 IVD CE Other names CRP Product category Immune Response, Infection and Inflammation, Sepsis Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0 to 10 μg/ml Limit of detection 0.02 μg/ml Applications serum, plasma Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

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MOUSE C-REACTIVE PROTEIN ELISA, HIGH SENSITIVITY

Cat. No. RH971CRP01MR RUO Other names CRP Product category Animal studies, Immune Response, Infection and Inflammation, Sepsis Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 1.56 to 25.0 ng/ml Limit of detection 2.5 ng/ml Applications serum, plasma, fluids Sample requirements 5 µl/well Storage/Shipping 2–8 °C/Wet ice

RAT C-REACTIVE PROTEIN ELISA, HIGH SENSITIVITY

Cat. No. RH951CRP01R RUO Other names CRP Product category Animal studies, Immune Response, Infection and Inflammation, Sepsis Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 1.6 to 133.3 ng/ml Limit of detection 2.5 ng/ml Applications serum, plasma, urine, synovial fluid, tissue extract, cell culture supernatant Sample requirements 5 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN CALCITONIN, HIGH SENSITIVITY ELISA Calcitonin(CT) is a 32 amino acid peptide hormone secreted by the para-follicular C-cells of the thyroid gland under serum calcium control. After acute

C administration, this peptide acts as a potent hypocalcemic and hypophosphatemic hormone by increasing renal calcium clearance and reducing bone resorption. However, its precise physiological role in bone metabolism is not yet fully understood. Various forms of CT may be detected in blood samples, including a CT monomer, an oxidized monomer, a dimer, higher molecular weight forms, and possibly precursor of CT. The concentrations of these peptides vary with clinical status, renal function and tissular origin of CT (normal or ectopic production). Medullar thyroid carcinoma (MTC) is a malignant tumor, de- veloped from the C-cells, secreting calcitonin in large excess. This disease occurs either as a sporadic (80%) or a familial (20%) form, which is transmitted as an autosomal dominant gene or as a component of multiple endocrine neoplasia (IIb). Moderate hypercalcitoninemia is also observed in pregnancy, pernicious anaemia, renal failure and during the neonatal period. Preferably, monomer form of CT is detected in this assay.

Cat. No. RIS0019R RUO Other names CT Product category Bone and cartilage metabolism, Oncology Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 10 to 400 pg/ml Limit of detection 0.7 pg/ml Applications serum Sample requirements 100 µl/well Storage/Shipping 2–8 °C/Wet ice

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HUMAN CARTILAGE OLIGOMERIC MATRIX PROTEIN ELISA COMP is a member of the thrombospondin family of extracellular proteins. It is present in the extracellular matrix of articular, nasal and tracheal cartilage. Serum levels of COMP provide important information about metabolic changes occuring in the cartilage matrix in joint disease and correlated with cartilage degradation. Serum COMP level is a potential prognostic marker in inflammatory joint diseases such as osteoarthritis and rheumatoid arthritis.

Cat. No. RD194080200 IVD CE Other names COMP, Thrombospondin-5, TSP5 Product category Bone and cartilage metabolism Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 4 to 128 ng/ml Limit of detection 0.4 ng/ml Applications serum, plasma Sample requirements 5 µl/well Storage/Shipping 2–8 °C/Wet ice

MOUSE CASPASE-1 ELISA Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin- 1β (IL-1β) and interleukin-18 (IL-18) and induces pyrop- totic cell death. Caspase-1 is synthesized as inactive pro-Caspase-1, wich is activated and processed by multiprotein complexes called inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3/NALP3 responds to a variety of agonists including crystals. Pro-Caspase-1, once activated by an inflammasome complex is processed into p20 and p10 subunits that assembles to form a p20-p20 /p10-p10 active complex that is secreted by a nonconventional (non-ER-dependent) mechanism.

Cat. No. RAG016R RUO Other names Interleukin-1β-Converting Enzyme IMMUNOASSAYS Product category Animal studies, Apoptosis, Immune Response, Infection and Inflammation Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.156 to 10 ng/ml Limit of detection 33 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements Storage/Shipping 2–8 °C/Wet ice

HUMAN CASPASE-8/FLICE ELISA Caspase-8 (55 kDa) is a protein binding the death effector domain of FADD. Caspase-8 plays an important role in all physiological disorders where apop- tosis is involved; primarily in the development (and treatment) of tumors and cardiac diseases.

Cat. No. RBMS2024R RUO Other names ICE-like apoptotic protease 5, MORT1-associated CED-3 homolog, FADD-homologous ICE/CED-3-like protease, FLICE, Apoptotic cysteine protease Product category Cardiovascular disease, Apoptosis Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.16 to 10 ng/ml Limit of detection 0.10 ng/ml Applications serum, cell culture supernatant, cell culture lysate Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

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HUMAN CASPASE-9 ELISA Caspase-9 is essentially localized in mitochondria, and the disruption of the outer mitochondrial membrane occurring early during apoptosis is critical for its subcellular redistribution and activation.It plays a crucial role in all pathologies involving apoptotic processes. Specifically, the involvement of cas- pase-9 has been described in human gastric cancer, ovarian carcinoma, neuroblastoma, gliomas as well as in Alzheimer´s disease,­ Huntington´s di­sease and osteoarthritis.

Cat. No. RBMS2025R RUO Other names ICE like apoptotic protease 6, Apoptotic protease Mch-6, Apoptotic protease activating factor 3 Product category Infection and inflammation, Apoptosis, Immune Response Assay format Sandwich ELISA, 2nd HRP-labelled antibody Calibration range 1.6 to 100 ng/ml Limit of detection 0.4 ng/ml Applications serum, cell culture supernatant, cell culture lysate Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN CATHEPSIN L ELISA Cathepsin L is a lysosomal endopeptidase belonging to the papain cysteine protease superfamily. Elevated levels of cathepsin L have been found in primary cell cultures from cancerous prostatic samples and in synovial lining from rheumatoid arthritis and osteoarthritis samples. Cathepsin L was found to be necessary for Li (invariant chain) degradation, a critical step in major histocompatibility complex class II – restricted antigen presentation, in cortical thymic epithelial cells, but not in bone marrow derived antigen-presenting cells.

Cat. No. RBMS257R RUO Other names Major excreted protein, MEP Product category Others Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 3.12 to 50 ng/ml Limit of detection 1.71 ng/ml

C Applications serum, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN sCD14 ELISA CD14 is a membrane-associated glycosylphosphatidylinositol-linked protein expressed at the surface of cells, especially macrophages. CD14 was the first described pattern recognition receptor. CD14 acts as a co-receptor (along with the Toll- like receptor TLR 4 and MD-2) for the detection of bacterial lipopolysaccharide. Soluble CD14 (sCD14), a 55-kDa glycoprotein found in plasma, has been shown to act as a shuttle for bacterial LPS and phospholip- ids, transporting LPS and phospholipid monomers from LPS aggregates or liposomes to high density lipoprotein particles. sCD14 has also been shown to mediate the transport of LPS and phosphatidylinositol into cells.

Cat. No. RGP001R RUO Other names Cluster of differentiation 14 Product category Cell surface proteins (sCD) Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 6.8 to 220 ng/ml Limit of detection < 6 ng/ml Applications serum, plasma, cell culture supernatant Sample requirements 100 µl/well Storage/Shipping 2-8 °C/ Wet ice

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HUMAN sCD21 ELISA CD21 is a 145 kDa transmembrane protein that contains 15 tandem SCR/SUSHI repeats. CD21 is primarily expressed on B cells, follicular dendritic cells, and T cells. It binds the complement component fragments iC3b, C3d, and C3d,g and forms complexes with CD19 and CD35. CD21 is required for germi- nal center development, antibody production, and B cell tolerance. It also functions as a cellular uptake receptor for Epstein-Barr virus.

Cat. No. RGP002R RUO Other names Cluster of differentiation 21, Complement receptor 2, CR2 Product category Cell surface proteins (sCD) Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 3.12 to 100 ng/ml Limit of detection < 3 U /ml Applications serum, plasma, cell culture supernatant Sample requirements 100 µl/well Storage/Shipping 2-8 °C/ Wet ice

HUMAN sCD23 ELISA CD23 (45 kDa) is described as a protein found on the surface of IgM bearing B cells, eosinophils, macrophages and some T and NK cells. Elevated levels of CD23 have been found in samples from people with B cell-derived Chronic Lymphocytic Leukemia, Hyper IgE Syndrome and post-Bone Marrow Transplanta- tion samples. CD23 levels may be related to the disease course in Hairy Cell Leukemia.

Cat. No. RBMS227/2R RUO Other names BLAST 2, FC epsilon RII, IgE binding factor, IgE receptor lymphocyte, Immunoglobulin E receptor low affinity II Product category Cell surface proteins (sCD)

Assay format Sandwich ELISA, Biotin-labelled antibody IMMUNOASSAYS Calibration range 12.5 to 400 U/ml Limit of detection 6.8 U/ml Applications serum, plasma, cell culture supernatant Sample requirements 100 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN sCD26 ELISA CD26 (110 kDa) is a cell surface glycoprotein with known dipeptidyl peptidase IV activity in its extracellular domain which is present on various cell types, including T cells and epithelial cells of the liver, kidney, and intestine. CD26 has been identified as a key marker for monocytotropic HIV-1 infection, with a mechanism of early loss of CD26– expressing cells in HIV-1 infected individuals. CD26 is an indicator of T-cell activation and CD26 level has been shown to fluctuate in parallel with several autoimmune diseases such as rheumatoid arthritis and autoimmune thyroiditis.

Cat. No. RBMS235R RUO Other names Dipeptidyl peptidase IV, Adenosine deaminase complexing protein 2, T cell activation antigen CD26, DPPIV Product category Diabetology, Cell surface proteins (sCD) Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 15.6 to 500 ng/ml Limit of detection 7.26 ng/ml Applications serum, cell culture supernatant Sample requirements 20 µl/well Storage/Shipping 2–8 °C/Wet ice

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HUMAN sCD28 ELISA CD28 (44 kDa) is a disulphide bonded, homodimeric glycoprotein which is constitutively expressed on the surface of the majority of T-cells. Activating the CD28/B7 pathway could be useful in promoting recognition and elimination of tumors that had previously evaded the immune system.

Cat. No. RBMS290R RUO Other names T-cell-specific surface glycoprotein CD28, TP 44 Product category Cell surface proteins (sCD) Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.8 to 50 to ng/ml Limit of detection 0.18 ng/ml Applications serum, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN sCD30 ELISA CD30 positivity is regarded as a peculiar attribute of Hodgkin‘s and Reed-Sternberg cells. High elevations of sCD30 levels are found in patients of systemic lupus erythematosus which correlate with disease activity. sCD30 is also a marker for autoimmune liver disease primary biliary cirrhosis and rheumatoid arthritis.

Cat. No. RBMS240R RUO Other names Lymphoid activation antigen CD30, Ki-1 antigen Product category Oncology, Cell surface proteins (sCD) Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 1.6 to 100 ng/ml Limit of detection 0.33 ng/ml Applications serum, plasma, cell culture supernatant Sample requirements 25 µl/well Storage/Shipping 2–8 °C/Wet ice C

HUMAN sCD30L ELISA CD30 ligand is a 40 kDa Type II transmembrane glycoprotein. It interacts with its receptor, CD30, as a homotrimer. CD153 is a member of the TNF super- family which is primarily expressed by activated T cells, B cells and monocytes. Its function in programmed cell death has been proven, and it has been shown that CD30L is involved in a variety of lymphoid malignancies like Hodgkin’s disease and anaplastic large cell lymphoma.

Cat. No. RBMS298R RUO Other names Tumor necrosis factor ligand superfamily member 8, CD30 ligand, CD153, TNFSF8 Product category Oncology, Apoptosis, Cell surface proteins (sCD) Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 1.6 to 100 U/ml Limit of detection 0.5 ng/ml Applications serum, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

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HUMAN sCD40 ELISA CD40 (50 kDa) is a membrane-bound type I glycoprotein expressed by numerous cells, most notably B lymphocytes and monocytes and antigen present- ing cells (APC) such as macrophages, dendritic cells and fibroblasts. CD40 belongs to the TNF-receptor family. Its critical role in T-cell-dependent humoral immune responses was demonstrated in patients with the hyper-IgM-Syndrome. The interaction of CD40 and its ligand, CD154 (CD40L) was found to play a crucial role in many aspects of immune response and the development and progress of various diseases.

Cat. No. RBMS265R RUO Other names B-cell associated molecule CD40, B-cell surface antigen CD40, CD40L receptor, Tumor necrosis factor receptor superfamily member 5 Product category Oncology, Apoptosis, Cell surface proteins (sCD) Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 7.8 to 500 pg/ml Limit of detection 6.92 pg/ml Applications serum, plasma, amniotic fluid, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

CD40L CD40 belongs to the TNF receptor superfamily. A key role of CD40/CD40ligand interactions in immune activation, particularly in T-cell dependent B cell responses is anticipated. This molecule as well as the other ligands of the family share the property of co-stimulation of T-cell proliferation and are all expressed by activated T-cells.Because the ligand of CD40 (CD40L) is expressed on activated T helper cells, B cells may escape from apoptosis and are activated when the immune system interacts with foreign antigens, which are normally able to activate T-helper cells. Thus the CD40/CD40L interaction plays a central role in the various phases of the B cell response to T-dependent antigens. IMMUNOASSAYS HUMAN sCD40L ELISA

Cat. No. RBMS239R RUO Other names CD40 ligand, Tumor necrosis factor ligand superfamily member 5, TNF related activation protein, T cell antigen Gp39, CD154 antigen Cardiovascular disease, Apoptosis, Cytokines and chemokines and related molecules, Cell surface proteins (sCD), Transplanta- Product category tion Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.16 to 10 ng/ml Limit of detection 0.06 ng/ml Applications serum, plasma, cell culture supernatant Sample requirements 20 µl/well Storage/Shipping 2–8 °C/Wet ice

MOUSE sCD40L ELISA

Cat. No. RBMS6010R RUO Other names CD40 ligand, Tumor necrosis factor ligand superfamily member 5, TNF related activation protein, T cell antigen Gp39, CD154 antigen Product category Cardiovascular disease, Autoimmunity, Apoptosis, Oncology, Animal studies, Cytokines, chemokines and related molecules, Cell surface proteins (sCD), Transplantation Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.31 to 20 ng/ml Limit of detection 0.14 ng/ml Applications serum, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

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HUMAN sCD44STD ELISA CD44 (85–250 kDa) is a polymorphic glycoprotein. Determination of sCD44std will provide more detailed insight into different pathological modifications during cancer and other diseases.

Cat. No. RBMS209/2R RUO Other names Phagocytic glycoprotein I, Extracellular matrix receptor-III, GP90 lymphocyte homing/adhesion receptor, Hermes antigen, Hyalu- ronate receptor, Heparan sulfate proteoglycan, Epican, CD44 antigen Product category Oncology, Autoimmunity, Cell adhesion proteins, Cell surface proteins (sCD), Immune Response, Infection and Inflammation Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.12 to 4 ng/ml Limit of detection 0.015 ng/ml Applications serum, urine, amniotic fluid, plasma, cell culture supernatant Sample requirements 20 µl/well (1:60 prediluted) Storage/Shipping 2–8 °C/Wet ice

HUMAN sCD44VAR (V5) ELISA CD44 is a polymorphic glycoprotein which participates in a wide variety of cell-cell or cell-matrix interactions including lymphocyte homing, establishment of B and T cell immune responses, tumor metastasis formation and inflammation. Determination of sCD44std will provide more detailed insight into differ- ent pathological modifications during cancer and other diseases.

Cat. No. RBMS220R RUO Other names Phagocytic glycoprotein I, Extracellular matrix receptor-III, GP90 lymphocyte homing/adhesion receptor, Hermes antigen, Hyalu- ronate receptor, Heparan sulfate proteoglycan, Epican, CD44 antigen Product category Oncology, Cell adhesion proteins, Cell surface proteins (sCD) Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 10 to 0.32 ng/ml Limit of detection 0.14 ng/ml Applications serum, plasma, cell culture supernatant

C Sample requirements 20 µl/well (1:6 prediluted) Storage/Shipping 2–8 °C/Wet ice

HUMAN sCD44VAR (V6) ELISA

Cat. No. RBMS210R RUO Other names Phagocytic glycoprotein I, Extracellular matrix receptor-III, GP90 lymphocyte homing/adhesion receptor, Hermes antigen, Hyalu- ronate receptor, Heparan sulfate proteoglycan, Epican, CD44 antigen Product category Oncology, Cell adhesion, Cell surface proteins (sCD) Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.32 to 10 ng/ml Limit of detection 0.05 ng/ml Applications serum, cell culture supernatant Sample requirements 20 µl/well (1:20 prediluted) Storage/Shipping 2–8 °C/Wet ice

94 For more information please go to www.biovendor.com IMMUNOASSAYS

HUMAN sCD134 (OX40) ELISA CD134 (OX40) is a member of the TNF receptor superfamily. Measurement of this molecule may have diagnostic value in polymyositis and granulomatous myopathy, T cell lymphoma and lymphomatoid papulosis, proliferative lupus nephritis, rheumatoid arthritis, HIV infection, viral infections of the lung, the regulation of graft-versus-host disease, myocarditis and dilated cardiomyopathy.

Cat. No. RBMS296R RUO Other names OX 40L receptor, ACT 35 Product category Cell surface proteins (sCD) Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 78 to 5000 pg/ml Limit of detection 1.8 pg/ml Applications serum, cell culture supernatant Sample requirements 25 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN sCD137/4-1BB ELISA CD137 (ILA/4–1BB) is a member of the tumor necrosis factor receptor family, expressed on activated T lymphocytes. The expression of CD137 is strictly activation-dependent in primary cells. The soluble isoforms of CD137, sCD137, are generated by differential splicing and can be detected at enhanced concentrations in sera of patients suffering from various diseases.

Cat. No. RBMS289R RUO Other names Tumor necrosis factor receptor superfamily member 9, T-cell antigen 4-1BB homolog, T-cell antigen ILA Product category Transplantation, Cell surface proteins (sCD)

Assay format Sandwich ELISA, Biotin-labelled antibody IMMUNOASSAYS Calibration range 0.8 to 50 ng/ml Limit of detection 0.2 ng/ml Applications serum, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN sCD152/CTLA-4 ELISA CTLA-4 was initially described as a classical type I glycoprotein on the surface of activated T-cells. A role for CTLA-4 in autoimmune disease is suggested by the observations that blockade of B7/CTLA-4 interaction exacerbates animal models of autoimmune disease such as experimental autoimmune encepha- lomyelitis and diabetes.

Cat. No. RBMS276R RUO Other names Cytotoxic T-lymphocyte protein 4, CD152 antigen Product category Transplantation, Cell surface proteins (sCD) Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.16 to 10 ng/ml Limit of detection 0.13 ng/ml Applications amniotic fluid, cell culture supernatant, plasma (EDTA, heparin), serum Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

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HUMAN CHEMERIN ELISA Chemerin is a novel chemoattractant protein secreted as an 18-kDa inactive pro-protein. Active chemerin is abundant in ascetic fluid from ovariam cancer patients and synovial fluid from patients with arthritis. Signaling by chemerin is mediated by the seven-transmembrane-spanning G protein-coupled receptor, chemokine like receptor-1 (CMKLR1, ChemR23,) or chemerinR. Both chemerin and chemerinR mRNA expression dramatically increased during the differentiation of preadipocytes into adipocytes. Chemerin induced the phosphorylation of extracellular signal – regulated kinase 1/2 (ERK 1/2) and lipolysis in differentiated adipocytes and 3T3-L1 cells, stimulated intracellular calcium release and inhibited cAMP accumulation. Chemerin disruption has some effect on adipogenesis in vitro, but regulation of gene expression and lipolysis in mature adipocytes suggests a wider role in lipid and carbohydrate metabolisms, and perhaps insulin sensitivity. Local production of chemerin regulates adipogenesis and through its receptor or possible other receptor can modulate a variety of functions in mature adipocytes. Adipocytes purified from adipose tissue contain high levels of chemerin mRNA; however, substantial expression in stromal vascular cells suggest that production in nonadipocytes may also be important. Chemerin is essential in early differentiation pro- cesses and may contribute or regulate critical early events in adipogenesis. Results also indicate that chemerin and ChemerinR could have an important biological role in the formation of white adipose tissue during normal or in pathological states.

Cat. No. RD191136200R RUO Other names Tezarotene induced gene 2, TIG2, Retinoic acid receptor responder 2, RERRES2 Product category Energy metabolism and body weight regulation Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.25 to 8 ng/ml Limit of detection 0.1 ng/ml Applications serum, plasma Sample requirements 5 μl/well Storage/Shipping 2–8 °C/Wet ice

CHORIONIC GONADOTROPIN Human Chorionic Gonadotropin (hCG) is a glycoprotein hormone normally produced by placenta during pregnancy. The hormone is present in blood and urine around seven to thirteen days following implantation of the fertilized ovum. Structurally intact hCG molecules consist of two non-covalently linked polypeptide subunits, the alpha and beta chain subunits. Measurement of intact hCG and of the alpha subunit of hCG appears to give similar results in blood and urine but not the levels of beta subunit. The measurement of free β-HCG in the first trimester of pregnancy has been reported as a useful marker in antenatal screening for Down Syndrome and other fetal aneuploidies. Increased free β-HCG values in combination with maternal age, the measurement of PAPP-A and the ultrasonic determination of nuchal translucency (NT) in pregnancy weeks 11 to 14 may detect up to 90 % of pregnancies with Down

C syndrom.

HUMAN CHORIONIC GONADOTROPIN ELISA

Cat. No. RCAN-CG-4120R RUO Other names hCG Product category Reproduction Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 2.5 to 500 IU/l Limit of detection 0.7 IU/l Applications serum Sample requirements 25 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN FREE BETA-CHORIONIC GONADOTROPIN ELISA

Cat. No. RIS0011R RUO Other names beta-hCG Product category Reproduction Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 10 to 200 ng/ml Limit of detection 0.2 ng/ml Applications serum Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

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HUMAN CHROMOGRANIN A ELISA Chromogranin A is an acidic secretory protein consisting of 439 amino acids. The protein is found in a wide variety of hormone and neurotransmitter stor- age vesicles, and it is known be co-stored and co-relased with catecholamines from adrenal medulla and sympathetic neuronal vesicles during exocytosis. High concentrations of plasma or serum CgA have been measured in patients with neuroendocrine and endocrine tumors.

Cat. No. RSCYK070R RUO Other names CgA, Pituitary secretory protein I, SP-I, CHGA Product category Oncology Assay format Competitive ELISA, Immobilized antibody Calibration range 0.14 to 33.33 pmol/ml Applications plasma, urine, saliva Sample requirements 25 μl/well Storage/Shipping 2–8 °C/Wet ice

RAT CINC-1 ELISA CINC-1 is a peptide of molecular weight of 7 845 Da, and it is a factor promoting migration of neutrophils. It induces release of cellular enzyme and is also involved in inflammation processes.

Cat. No. RSCPRI121R RUO Other names Cytokine-Induced Neutrophil Chemoattractant Product category Animal studies, Cytokines, chemokines and related molecules Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 12.5 to 800 ng/ml

Applications serum, plasma IMMUNOASSAYS Sample requirements 100 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN CLARA CELL PROTEIN ELISA CC16 belongs to the family of secretoglobins expressed predominantly in non-ciliated bronchiolar Clara cells and is a peripheral blood biomarker of lung injury assessing the cellular integrity or the permeability of the lung epithelium. Clinical studies have shown that circulating Clara Cell Protein rises in serum of patients with acute respiratory distress syndrome, idiopathic interstitial pneumonia, sarcoidosis as well as after exposure to environmental air pollutants or fire smoke.

Cat. No. RD191022200 IVD CE Other names CC16, CC10, Uteroglobin, Urinary protein 1, Clara cell secretory protein Product category Immune Response, Infection and Inflammation, Pulmonary diseases Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 1.57 to 50 ng/ml Limit of detection 46 pg/ml Applications serum, plasma Sample requirements 5 µl/well Storage/Shipping 2–8 °C/Wet ice

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CLUSTERIN Clusterin (75-80 kDa), glycoprotein, is secreted by epithelial and neuronal cells and is major protein in physiological fluids. Clusterin is induction in many severe physiological disturbances states including kidney degenerative diseases, prostate and vesicle carcinogenesis, ovarian cancer and neurodegenera- tive conditions. Measurement of urinary Clusterin levels may be a useful clinical marker for the severity of renal tubular damage. It may help to differentiate between tubular and glomerular forms of proteinuria. Recently clusterin has become a significant marker of kidny injury. The determination of the clusterin concentration in rat blood may be a promissing novel test of nephrotoxicity.

CANINE CLUSTERIN ELISA

Cat. No. RD491034200R RUO Other names Apolipoprotein J, Apo J Product category Renal disease, Sepsis, Others, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 4 to 128 ng/ml Limit of detection 0.2 ng/ml Applications serum, urine Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN CLUSTERIN ELISA

Cat. No. RD194034200R RUO Other names Apolippoprotein J, Apo J Product category Others, Renal disease, Sepsis Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 5 to 160 ng/ml Limit of detection 0.5 ng/ml Applications serum, plasma, cerebrospinal fluid, urine, cell lysate C Sample requirements 5 µl/well Storage/Shipping 2–8 °C/Wet ice

RAT CLUSTERIN ELISA

Cat. No. RD391034200R RUO Other names Apolippoprotein J, Apo J Product category Animal studies, Others, Renal disease, Sepsis Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 4 to 128 ng/ml Limit of detection 0.7 ng/ml Applications serum, urine Sample requirements 5 µl/well Storage/Shipping 2–8 °C/Wet ice

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HUMAN CORTICOSTEROID-BINDING GLOBULIN ELISA Corticosteroid binding globulin (CBG) is synthesized and secreted by hepatocytes in the liver and is present in glycocorticoid responsive cells. CBG is the major transport protein for progestins and glucocorticoids within the blood. Plasma CBG levels increase during pregnancy and are decreased in cirrho- sis. Estrogen therapy (e.g. feeding hormonal contraception) or implantation during pregnancy cause a very marked increase of the CBG concentration. Decreased levels of CBG are observed in women with polycystic ovary syndrome, hypoproteinemia, Cushing´s syndrome or corticoid treatment and some cases of vitamin B12 deficiency. Extremely low levels of CBG have been reported in patients with septic shock. The main clinical application of corticoster- oid binding globulin measurement relates to the interpretation of cortisol levels. The concentration of unbound cortisol, which is biologically active, can be calculated from the concentration of total cortisol and that of CBG on the basis of mass action.

Cat. No. RD192234200R RUO Other names Transcortin, CBG, Serpin A6 Product category Immune Response, Infection and Inflammation, Steroid hormones Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 3.13 to 200 ng/ml Limit of detection 0.01 ng/ml Applications serum, plasma Sample requirements 5 µl/well Storage/Shipping 2–8 °C/Wet ice

CORTICOSTERONE Corticosterone is a glucocorticoid hormone secreted from the cortex of adrenal gland. Corticosterone is derived from cholesterol through a series of enzymatically mediated steps and also serving as a precursor of aldosterone. It is a primary glucocorticoid in mice and rats and other animals (such as rabbits, birds, amphibians, and reptilians) in which the 17α-hydroxylase is supposed not to exist in adrenal gland. Corticosterone is produced under the control of ACTH and the production has a circadian rhythm with peak levels in the latter portion of the day in nocturnal animals like rats and is believed to

play a decisive role in sleep-wake cycles. Corticosterone can be used as a non-invasive biomarker of stress study through the collection of urine and feces IMMUNOASSAYS to avoid corticosterone increase of blood levels which is caused by normal invasive methods. Corticosterone is also being studied in different fields such as impairment of long-term memory retrieval, chronic corticosterone elevation due to dietary restrictions and response to burn injuries etc.

HUMAN CORTICOSTERONE (MULTISPECIES SPECIFICITY) ELISA

Cat. No. RSCYK240R RUO Product category Animal studies, Steroid hormones Assay format Competitive ELISA, Immobilized antibody Calibration range 0.21 to 50 ng/ml Limit of detection 0.21 to 50 ng/ml Applications serum, urine, plasma, cell culture supernatant Storage/Shipping 2–8 °C/Wet ice

MOUSE/RAT CORTICOSTERONE ELISA

Cat. No. RTC002R RUO Product category Animal studies, Steroid hormones Assay format Competitive ELISA, Immobilized antigen Calibration range 15 to 2250 ng/ml Limit of detection 4.1 ng/ml Applications serum, plasma Storage/Shipping 2–8 °C/Wet ice

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MOUSE/RAT CORTICOTROPIN RELEASING FACTOR ELISA, SENSITIVE, EXTRACTION-FREE CRF is a 41-amino acid polypeptide hormone and neurotransmitter involved in the stress response. It is produced by neuroendocrine cells in the paraven- tricular nucleus of the hypothalamus and is released from neurosecretory terminals of these neurons into the primary capillary plexus of the hypothalamo- hypophyseal portal system. The portal system carries the CRH to the anterior lobe of the pituitary, where it stimulates corticotropes to secrete corticotropin and other biologically active substances.

Cat. No. RSCYK131R RUO Other names CRF Product category Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.078 to 2.5 ng/ml Applications plasma, brain extracts Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

CORTISOL Cortisol is the most abundant circulating steroid and the major glucocorticoid secreted by the adrenal cortex. Cortisol is physiologically effective in blood pressure maintenance and anti-inflammatory activity. It is also involved in calcium absorption, gluconeogenesis as well as the secretion of gastric acid and pepsin. Measurement of blood cortisol levels can be used as an indicator of adrenal function and the differential diagnosis of Addison‘s and Cushing‘s dis- eases as well as adrenal hyperplasia and carcinoma.

CORTISOL ELISA

Cat. No. RCAN-C-270R RUO Product category Steroid hormones Assay format Competitive ELISA, Immobilized antigen Calibration range 0.5– 60 μg/dl Limit of detection 0.4 μg/dl C Applications serum Sample requirements 20 μl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN CORTISOL (SALIVA) ELISA

Cat. No. RCAN-C-290R RUO Product category Steroid hormones Assay format Competitive ELISA, Immobilized antigen Calibration range 1 to 100 ng/ml Limit of detection 1 ng/ml Applications saliva Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

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HUMAN CTRP1 ELISA CTRP-1 expression is induced by proinflammatory cytokines, including TNF-α and IL-1β. It is expressed at high levels in adipose tissue and in the zona glomerulosa of the adrenal cortex, where aldosterone is produced. In addition to finding a dose-dependent increase in aldosterone production by CTRP-1, it has been found that angiotensin II-induced aldosterone production was, at least in part, mediated by the stimulation of CTRP-1 secretion. CTRP-1 is stimulating aldosterone production through induction of CYP11B2 gene expression. Therefore, CTRP-1 could be a molecular link between obesity and hypertension. CTRP-1 is also a vascular wall protein that inhibits collagen-induced platelet aggregation by blocking VWF binding to collagen.

Cat. No. RD191153100R RUO Other names Complement C1q tumor necrosis factor-related protein 1, G protein-coupled receptor-interacting protein, GIP, C1QTNF1 Product category Energy metabolism and body weight regulation Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 3.13 to 100 ng/ml Limit of detection 0.016 ng/ml Applications serum, plasma (citrate) Sample requirements 8 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN CTRP3 ELISA C1q- and tumor necrosis factor-related protein, CTRP or C1QTNF, is a rapidly-expanding cytokine family. There are 13 members of the CTRP family that have been identified. Each CTRP is comprised of the NH2 terminal half representing a proline-rich collagen domain preceded by a signal sequence and a hypervariable region, which can accelerate multimeric forms, and the COOH terminal half globular domain resembling TNF-α and RANKL in terms of 3D structure. Their overall structure is very similar to adiponectin. Therefore, CTRPs are the adiponectin paralogs. One interesting feature of the CTRP family is that their amino acids are quite conserved between species, implying their biological importance. CTRP3 or C1QTNF3 encodes a deduced 246-amino acid protein with a calculated molecular mass of 26 kDa. RT-PCR analysis detected expression in cDNAs from human osteosarcoma, chondroblastoma, and

giant cell tumor, as well as in normal fibroblasts, white adipose tissue, and placenta. Circulating CTRP3 was observed in both mouse and human serum or IMMUNOASSAYS plasma. CTRP3 was also known as Cors26 whose primary expression is in cartilage and overexpression of CTRP3 increased the growth of murine mesen- chymal stem cells, suggesting that it plays a role in skeletal development. Circulating CTRP3 levels correlated inversely with circulating leptin levels in mice. CTRP3 expression decreased with diet-induced obesity in wild type mice with high leptin levels and increased with fasting in wild type mice and in obese leptin-deficient and insulin-resistant ob/ob mice. Administration of sufficient recombinant CTRP3 to increase its plasma levels 3-fold activated Akt signal- ing in liver, directly and independently of insulin suppressed hepatic glucose output via inhibition of gluconeogenesis, and lowered blood glucose levels in both normal and ob/ob mice. Visceral adipocytes or monocytes secrete CTRP3 that antagonizes lipopolysaccharide (LPS) via a physical interaction with the TLR4/MD-2 receptor complex. Due to these metabolically beneficial or anti-inflammatory feature(s) associated with CTRP3 the measurement of CTRP3 becomes intriguing.

Cat. No. RAG002R RUO Other names Complement C1q tumor necrosis factor-related protein 3 Product category Energy metabolism and body weight regulation Assay format Competitive ELISA, Immobilized antigen Calibration range 0.001 to 1 μg/ml Limit of detection 1 ng/ml Applications serum, plasma, cell culture supernatant Storage/Shipping 2–8 °C/Wet ice

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HUMAN CTRP5 ELISA CTRP5 is a member of the C1q and tumor necrosis factor superfamily whose structure resembles adiponectin, being a 25 kD secretory protein. CTRP5 was identified in a cDNA library enriched for genes showing expression specific for the retinal pigment epithelium (RPE). A subsequent RT-PCR study demon- strated CTRP5 expression in RPE, liver, lung, placenta, and brain. It has been proposed that a CTRP mutation (S163R) plays a critical role in affecting its higher order protein structure, potentially leading to a cause of abnormal adhesion between the RPE and Bruch membrane. A recent data showed that CTRP is one of the genes highly induced by elimination of mitochondria and was able to activate AMPK in a rat myotube cell line, L6. Stimulation of L6 with recombinant CTRP5, full length as well as globular domain, enhanced glucose uptake and fatty acid oxidation. These biochemical events did not seem to be mediated via AdipoR1 or AdipoR2, suggesting that a novel receptor(s) may exist for CTRP5 in this muscle cell line. Some CTRP members can physically interact with adiponectin, forming various multimeric structures. A compensatory upregulation of mouse CTRP members was observed in adiponectin- deficient mice. Therefore, measuring serum or plasma CTRP5 may provide important information on its involvement in novel metabolism.

Cat. No. RAG003R RUO Other names Complement C1q tumor necrosis factor-related protein 5 Product category Energy metabolism and body weight regulation Assay format Competitive ELISA, Immobilized antigen Calibration range 0.001 to 5 μg/ml Limit of detection 1 ng/ml Applications serum, plasma, cell culture supernatant Storage/Shipping 2–8 °C/Wet ice

HUMAN CTRP9 ELISA Complement C1q tumor necrosis factor-related protein 9 (C1q/TNF-related protein 9; CTRP9) is a highly conserved paralog of adiponectin. Of all the CTRP paralogs, CTRP9 shows the highest degree of amino acid identity to adiponectin in its globular C1q domain. CTRP9 protein exists in two isoforms, CTRP9A and CTRP9B. Although human CTRP9A and CTRP9B share 98% amino acid identity, they are encoded by distinct genes and are biochemically distinct. Human CTRP9A but not CTRP9B is expressed by adipose tissue. CTRP9B is expressed at very low levels in tissues. While CTRP9A is robustly secreted as a multimeric protein, CTRP9B requires physical association with CTRP9A or adiponectin for its secretion. CTRP9 is expressed predominantly in adipose tissue and females express higher levels of the transcript than males. Moreover, its expression levels in ob/ob mice changed in an agedependent manner, with significant up-regulation in younger mice. Adenovirus-mediated overexpression of CTRP9 in obese (ob/ob) mice significantly lowered serum glucose levels. CTRP9 is a secreted glycoprotein with multiple post-translational modifications in its collagen domain that include hydroxylated prolines and hydroxylated and glycosylated lysines. It is secreted as multimers (predominantly trimers) from transfected cells and circulates in the mouse serum with levels varying according to sex and metabolic state of mice. Furthermore, CTRP9 and adiponectin can be secreted as heterooligomers when cotransfected into mamma- C lian cells, and in vivo, adiponectin/CTRP9 complexes can be reciprocally coimmunoprecipitated­ from the serum of adiponectin and CTRP9 transgenic mice. The functional role of the plasma CTRP9 in ischemic heart disease is unknown. Systemic delivery of CTRP9 reduces myocardial infarct size and apoptosis following ischemiareperfusion in mice. CTRP9 protects cardiomyocyte from apoptosis through activation of AMPactivated protein kinase (AMPK). CTRP9 prevents acute cardiac ischemic injury via an AMPKdependent mechanism. The data indicate that CTRP9 functions to attenuate neointimal formation fol- lowing vascular injury through its ability to inhibit vascular smooth muscle cell (VSMC) growth via cAMPdependent mechanism, suggesting that the thera- peutic approaches to enhance CTRP9 production could be valuable for prevention of vascular restenosis after angioplasty. CTRP9 is a novel vasorelaxive adipocytokine which may exert vasculoprotective effects via the AdipoR1/AMPK/eNOS dependent/NO mediated signaling pathway. The vasoactive potency of CTRP9 exceeded that of adiponectin by 3-fold. Cardiac expression of CTRP9, exceeds adiponectin by >100-fold, and is significantly reduced in high-fat diet-induced diabetic mice. In H9c2 cells, TNF-α strongly inhibited CTRP9 expression (>60 %), and significantly reduced peroxisome proliferator activated receptorgamma (PPARγ), a known transcription factor promoting adiponectin expression.

Cat. No. RD191180200R RUO Other names CTRP9A, Complement C1q tumor necrosis factor-related protein 9, C1QTNF9,C1QTNF9A,UNQ6503/PRO21380 Product category Cardiovascular disease, Energy metabolism and body weight regulation Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 25 to 800 pg/ml Limit of detection 9.0 pg/ml Applications serum, plasma Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

102 For more information please go to www.biovendor.com IMMUNOASSAYS

HUMAN Cu/Zn SUPEROXIDE DISMUTASE ELISA Superoxide dismutase is the antioxidation enzyme existing in a wide variety of biological systems, and it shows typical antioxidation activity similar to glutathione and ascorbic acid. It plays an important role in inhibiting the negative effects of oxidative stress in living systems. Cu,Zn-SOD detected in cyto- plasma has a dimeric structure which consists of subunits having the molecular weight of 32 kDa.

Cat. No. RBMS222R RUO Other names Cu/ZnSOD Product category Oxidative stress Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.08 to 5 ng/ml Limit of detection 0.04 ng/ml Applications serum, plasma, urine, amniotic fluid, cell culture supernatant, fetal umbilical vein blood Sample requirements 10 µl/well (1:20 prediluted) Storage/Shipping 2–8 °C/Wet ice

CYSTATIN C Cystatin C (13,3 kDa, 120 amino acids) belongs to the cystatins superfamily and have been identified in animals, plants and protozoa. It is produced by all nucleated body cells and occurs in all body fluids abundantly. The protein is encoded by the CS73 gene located on the short arm of chromosome 20. Imbalance between Cystatin C and cysteine proteinases is associated with diseases such as inflammation, renal failure, cancer, Alzheimer disease, multi- ple sclerosis and heraditary Cystatin C amyloid angiopathy. Serum or plasma Cystatin C was found to be a very sensitive marker of changes in glomerular filtration rate. Urine Cystatin C levels indicate insufficient protein resorption by kidney.

CANINE CYSTATIN C ELISA IMMUNOASSAYS Cat. No. RD491009100R RUO Other names CST3, Post G-globulin Product category Animal studies, Neural tissue markers, Renal disease Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.31 to 10 ng/ml Limit of detection 0.005 ng/ml Applications Serum, Urine Sample requirements 5 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN CYSTATIN C ELISA

Cat. No. RD191009100 IVD CE Other names CST3, Post G-globulin Product category Neural tissue markers, Renal disease Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 200 to 10000 ng/ml Limit of detection 0.25 ng/ml Applications serum, plasma, urine, cerebrospinal fluid Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

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MOUSE CYSTATIN C ELISA

Cat. No. RD291009200R RUO Other names CST3, Post G-globulin Product category Animal studies, Neural tissue markers, Renal disease Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.156 to 10 ng/ml Limit of detection 0.04 ng/ml Applications serum Sample requirements 5 µl/well Storage/Shipping 2–8 °C/Wet ice

RAT CYSTATIN C ELISA

Cat. No. RD391009200R RUO Other names CST3, Post G-globulin Product category Animal studies, Neural tissue markers, Renal disease Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.78 to 25 ng/ml Limit of detection 0.008 ng/ml Applications serum Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN CYTOCHROME c ELISA Mitochrondrial cytochrome c (15 kDa) is a water–soluble protein. Cytochrome c functions in the respiratory chain by interacting with redox partners. It is highly conserved during evolution. Measurement of cytochrome c release from the mitochondria is a tool to detect the first early steps of initiation of –E apoptosis in cells. C

Cat. No. RBMS263R RUO Other names CYC Product category Apoptosis, Immune Response, Infection and Inflammation, Oxidative stress Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.08 to 5 ng/ml Limit of detection 0.05 ng/ml Applications cell culture lysate Sample requirements 100 µl/well Storage/Shipping 2–8 °C/Wet ice

DEHYDROEPIANDROSTERONE SULFATE ELISA Dehydroepiandrosterone­ sulfate (DHEAS) is produced by the adrenals and gonads. As a result, the determination of the level of DHEA-S in serum is important in the evaluation of the functional state of these glands. DHEAS is a precursor of testosterone and estrone. Besides the adrenals in females, the ovaries have been shown to be an important source of DHEAS. It has been reported that there is a fluctuation day by day of DHEAS in women during the ovulatory cycle. An abnormal testosterone level in women should be accompanied by the estimation of serum DHEAS. The use of serum testosterone determination in conjunction with Elisa of DHEAS can be used to determine if the source of excess androgen production is ovarian or adrenal.

Cat. No. RCAN-DHS-480R RUO Other names DHEAS Product category Steroid hormones Assay format Competitive ELISA, Immobilized antigen Calibration range 0 .005 to 10 μg/ml Limit of detection 0.005 μg/ml Applications serum Sample requirements 25 μl/well Storage/Shipping 2–8 °C/Wet ice

104 For more information please go to www.biovendor.com IMMUNOASSAYS

HUMAN DICKKOPF-RELATED PROTEIN 1 ELISA Dickkopf-related protein 1 (Dkk-1) is a head inducer secreted from the vertebrate head organizer and belongs to the DKK protein family. Dkk-1 may play a key role in regulating pre-osteoblast differentiation and the development of multiple myeloma-associated osteolytic bone lesions. During embryogenesis, DKK1 mediated Wnt inhibition controls the spatiotemporal dynamics of cell fate determination, cell differentiation and cell death. Furthermore, the Dkk-1 dose is critical for the normal Wnt homeostasis, as alteration of the Dkk-1 activity is associated with various diseases.

Cat. No. RD191207200R RUO Other names Dkk-1, DKKL1 Product category Bone and cartilage metabolism, Oncology Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.125 to 4 ng/ml Limit of detection 0.01 ng/ml Applications serum Sample requirements singlet 50 µl/well, doublet 100 µl/well Storage/Shipping 2-8 °C/ Wet ice

DIHYDROTESTOSTERONE ELISA 5-dihydrotestosterone (DHT) is a steroid similar to testosterone and androstenedione, which belong to a vlase called androgens. DHT is a C19 steroid and possesses androgenic activity. The bulk of androgen production takes place mainly in the Leydig cells of the testes. Androgens circulate in the blood bound to proteins, especia lly sex hormone binding globulin (SHBG) and albumin. A trace amount of these steroids circulate in the unbound form in the blood and are referred to as the free fractions. DHT has at least three times the binding affinity for SHBG than testosterone. In males about 70% of DHT is derived from peripheral conversion of testosterone, while in females most of the DHT is derived from androstenedione. The major organ to neutralize andro- gens is the liver. Therefore in the liver the steroid hormones undergo structural modifications that are generally regarded as prerequisites for their biological inactivation. Some metabolites are formed and some are returned to the circulation IMMUNOASSAYS Cat. No. RCAN-DHT-280R RUO Other names DHT Product category Steroid hormones Assay format Competitive ELISA, Immobilized antigen Calibration range 25 to 2500 pg/ml Limit of detection 6.0 pg/ml Applications serum Sample requirements 50 μl/well Storage/Shipping 2–8 °C/Wet ice

MOUSE EOTAXIN ELISA Eotaxin is a member of the CC chemokine family of inflammatory and immunoregulatory cytokines. Eotaxin expression has been detected in smooth mus- cle cells, chondrocytes and eosinophils. Mouse Eotaxin has been shown to be a potent chemoattractant for eosinophils during inflammation and allergic reactions, and it is involved in the growth of myeloid cell progenitors and differentiation of mast cells during embryonic development. A role in numer- ous eosinophil-associated gastrointestinals disorders such as food allergy, parasitic infections, allergic colitis and inflammatory Bowel disease has been described.

Cat. No. RBMS6008R RUO Other names Small-inducible cytokine A11, Eosinophil chemotactic protein, Small inducible cytokine subfamily A (Cys-Cys), member 11, CCL11 Product category Animal studies, Immune Response, Infection and Inflammation Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 31.3 to 2000 pg/ml Limit of detection 3.6 pg/ml Applications serum, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

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HUMAN EPIDERMAL FABP ELISA Human epidermal fatty acid binding protein (EFABP, FABP5 and in mice called also mal1) is a 15 kD member of the fatty acid binding protein family, which is known for the ability to bind fatty acids and related compounds (bile acids and retinoids). The epidermal fatty acid binding protein and adipocyte fatty acid binding protein (AFABP, FABP4) are closely related and both are expressed in adipocytes. Absence of EFABP/mal1 resulted in increased systemic insulin sensitivity in models of obesity and insulin resistance. Adipocytes isolated from mal1-deficient mice also exhibited enhanced insulin-stimulated glucose transport capacity. In contrast, mice expressing high levels of mal1 in adipose tissue display reduced systemic insulin sensitivity.

Cat. No. RD191060200R RUO Other names EFABP, FABP5, Epidermal Fatty Acid Binding Protein Product category Cardiovascular disease Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.5 to 40 ng/ml Limit of detection 0.05 ng/ml Applications serum, plasma, milk, tissue culture medium, tissue extract, urine Sample requirements 30 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN ERYTHYROPOIETIN ELISA Erythropoietin (EPO) is a hormone produced by the kidney that promotes the formation of red blood cells in the bone marrow. The measurement of EPO in the blood is useful in the study of bone marrow disorders and kidney disease. Elevated levels of EPO can be seen in polycythemia, a disorder in which there is an excess of red blood cells. Lower than normal levels of EPO are seen in chronic renal failure. EPO plays an important role in the brain’s response to neuronal injury. EPO is also involved in the wound healing process.

Cat. No. RBMS2035R RUO Other names EPO Product category Bone and cartilage metabolism, Renal disease Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 1.6 to 100 mIU/mL

–F Limit of detection 0.17 mIU/mL

E Applications serum, plasma, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

ESTRADIOL ELISA Estradiol is one of the main components of naturally occurring estrogens and is the major estrogen secreted during the menstrual cycle. The serum levels of estradiol are low during the follicular phase rising gradually until about one day before ovulation when a marked rise in the estradiol level occurs (Ovula- tory Peak). The estradiol level falls rapidly at, or right after ovulation and is again within the levels of the follicular phase. There is a second rise of estradiol around day 21 of the cycle (Luteal Peak). The levels then decline gradually to the lowest level at the onset of the next menstrual cycle.

Cat. No. RCAN-E-430R RUO Product category Steroid hormones Assay format Competitive ELISA, Immobilized antigen Calibration range 20 to 3200 pg/ml Limit of detection 10 pg/ml Applications serum Sample requirements 50 μl/well Storage/Shipping 2–8 °C/Wet ice

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HUMAN FREE ESTRIOL ELISA Estriol (E3) is the major estrogen formed by the fetoplacental unit during pregnancy. Unconjugated E3 passes through the placenta into the maternal circulation, where it is rapidly converted into glucuronide and sulfate derivatives to facilitate its excretion. The half-life of estriol in the maternal bloodstream is only 20–30 minutes. Its measurement, therefore offers a convenient and quick evaluation of current fetal status. Plasma estriol levels increase steadily throughout pregnancy and most rapidly during the third trimester (28–40 weeks). A sudden decrease in fetoplacental E3 production will result in a rapid fall in unconjugated E3 in the maternal serum. There are several potential advantages to measuring unconjugated E3 rather than total serum or urinary E3. Unconjugated estriol levels are free from effects related to maternal renal or hepatic disease, and are not altered by the administration of certain antibiot- ics. Unconjugated E3 more accurately reflects fetal outcome in diabetic pregnancies – and since no hydrolysis of unconjugated E3 is required, a more rapid turnaround for the test result is possible.

Cat. No. RIS009R RUO Other names E3 Product category Steroid hormones Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.3 to 40 ng/ml Limit of detection 0.075 ng/ml Applications Serum Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

ESTRONE ELISA Estrone is a steroid like estriol and estradiol, belonging to the class of estrogens. The estrogens are involved in the development of female sex organs and secondary sex characteristics. Before the ovum is fertilized the main action of the estrogens is on the growth and function of the reproductive tract in order to prepare it for the fertilized ovum. During the follicular phase of the menstrual cycle the estrone level shows a slight increase. IMMUNOASSAYS Cat. No. RCAN-E-420R RUO Product category Steroid hormones Assay format Competitive ELISA, Immobilized antigen Calibration range 15 to 2000 pg/ml Limit of detection 10.0 pg/ml Applications serum Sample requirements 50 μl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN sFAS LIGAND ELISA Fas is a type I membrane protein that belongs to the TNF/nerve growth factor receptor family. Fas mediates apoptosis, the programmed cell death, when it is cross-linked with specific binding partners. FasL is predominantly expressed on activated T-cells and NK cells; thus FasL-mediated cell death is involved in the T or NK cell-mediated cytotoxicity, some pathologic tissue damages, and the regulation of lymphocyte homeostasis. Elevated expression levels of FasL have been measured in various proliferative disorders and cancers.

Cat. No. RBMS260/2R RUO Other names CD178 antigen, CD95 ligand Product category Apoptosis Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.16 to 10 ng/ml Limit of detection 0.07 ng/ml Applications serum, plasma, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

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FERRITIN Ferritin, molecular weight 450 000, is iron storage protein containing 24 units of 2 different subunits at various ratios. It contains 4 500 iron atoms in a molecule. Ferritin exist in spleen, liver, red marrow, small intestinal mucosa and muscle, and involve in iron metabolism of inner or outer cellular. Ferritin is a source of supply for metallic iron, and has a role to store iron, which catalyzes the hydroxy-radical synthesize reaction, into core of protein molecule. Determination of ferritin in serum is useful for diagnostic of disorder in iron metabolism, hepatic disease and malignant tumor.

HUMAN FERRITIN ELISA

Cat. No. RCAN-F-4280R RUO Product category Iron metabolism Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0 to 1500 ng/ml Limit of detection 7.5 ng/ml Applications serum Sample requirements 20 µl/well Storage/Shipping 2–8 °C/Wet ice

RAT FERRITIN ELISA

Cat. No. RSCPRA011R RUO Product category Iron metabolism, Animal studies Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 3.13 to 100 ng/ml Applications serum Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice F HUMAN FETUIN-A (AHSG) ELISA Fetuin-A (59 kDa), a glykoprotein, consisting of two cystatin-like domains and a smaller unrelated domain. Liver synthesized Fetuin-A is secreted into the blood stream and it is deposited as a noncollagenous protein in mineralized bones and teeth. Fetuin-A acts as an important circulating inhibitor of ectopic calcification. Fetuin-A may play a significant role in regulating postprandial glucose disposal, insulin sensitivity, weight gain, and fat accumulation and may be a novel therapeutic target in the treatment of type 2 diabetes, obesity, and other insulin-resistant conditions.

Cat. No. RD191037100 IVD CE Other names Alpha-2-HS-glycoprotein, Ba-alpha-2-glycoprotein, Alpha-2-Z-globulin, AHSG Product category Bone and cartilage metabolism, Cardiovascular disease, Renal disease Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 2 to 100 ng/ml Limit of detection 0.104 ng/ml Applications serum, plasma Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

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HUMAN FIBROBLAST GROWTH FACTOR-19 ELISA FGF-19 is a member of a large family of small (17-26 kDa) polypeptide growth factors. The initial characterization of these proteins focused on their ability to stimulate fibroblast proliferation. FGF-19 exhibits exclusive binding to only one of FGF receptors FGFR4. The normal function of FGF-19 has not been resolved, even if a role for inner ear development has been suggested. It has been also found that hepatocyte expression of FGF-19 is induced by the tran- scription factor farnesoid X receptor (FXR) a key regulator of cholesterol metabolism. Recently study shows that, in humans, circulating FGF-19 has diurnal rhythm controlled by transintestinal BA flux, and that FGF-19 modulates hepatic bile acids synthesis.

Cat. No. RD191107200R RUO Other names FGF-19 Product category Energy metabolism and body weight regulation Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 12.5 to 800 ng/ml Limit of detection 4.8 pg/ml Applications serum, plasma Sample requirements 50 μl/well Storage/Shipping 2–8 °C/Wet ice

FIBROBLAST GROWTH FACTOR-21 FGF-21 is a member of FGFs family. FGF-21 is expressed in liver and regulates glucose uptake in human fat cells. Therapeutic administration of FGF-21 decreased plasma glucose levels and triglycerides to near normal levels in multiple mouse models of type 2 diabetes. FGF-21, when overexpressed, protected animals from diet-induced obesity. These results define a functional role for FGF-21 in vivo and provide evidence that FGF-21 can lower glucose and triglyceride levels in diabetic animals. In contrast of several members of FGFs family, which may induce therapeutically undesirable in vivo proliferation of various cell types, recent study demonstrated, that FGF-21 did not induce mitogenicity, hypoglycemia or weight gain at any dose tested in diabetic or healthy animals or when overexpressed in transgenic mice. IMMUNOASSAYS

HUMAN FIBROBLAST GROWTH FACTOR-21 ELISA

Cat. No. RD191108200R RUO Other names FGF-21 Product category Energy metabolism and body weight regulation Assay format Sandwich ELISA, Biotin-labelled antibod Calibration range 30 to 1920 pg/ml Limit of detection 7 pg/ml Applications serum, plasma Sample requirements 75 μl/well Storage/Shipping 2–8 °C/Wet ice

MOUSE/RAT FIBROBLAST GROWTH FACTOR-21 ELISA

Cat. No. RD291108200R RUO Other names FGF-21 Product category Energy metabolism and body weight regulation, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 40 to 2560 pg/ml Limit of detection 18.4 pg/ml Applications serum, plasma, cell culture medium Sample requirements mouse samples 7 µl/well, rat samples 50 µl/well Storage/Shipping 2-8 °C/Wet ice

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HUMAN FIBRONECTIN ELISA Fibronectin is an ubiquitous extracellular glycoprotein that exists in a soluble form in body fluids and in an insoluble form in the extracellular matrix. It plays a major role in many important physiological processes, such as embryogenesis, wound healing, hemostasis and thrombosis. Fibronectin is secreted as a dimer with a monomer molecular weight of 220–250 kDa. It is synthesized by, and present around, fibroblasts, endothelial cells, chondrocytes, glial cells, and myocytes. Fibronectin’s im­portance during cancer progression has further been shown. It represents an active element in the process of T cell activation in the immune cascade triggered by organ transplantation.

Cat. No. RBMS2028R RUO Other names Cold insoluble globulin, FINC, LETS, MSF, FN Product category Oncology, Transplantation Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.31 to 20 ng/ml Limit of detection 0.1 ng/ml Applications serum, plasma (EDTA, heparin), urine, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN FOLLISTATIN ELISA Follistatin (FST) is a monomeric glycosylated protein unrelated to inhibin with ability to specifically bind activin. Of various alternative splicing, glycosylation and proteolytic cleavage variants, the 288-residue molecule (FST288) and the 315-residue form (FST315) are capable of binding activin, although the affinity of FST288 may be higher than that of FST315. FST is produced and plays a regulatory role in gonads, pituitary gland, pregnancy membranes, liver and kidney, and also circulates in blood. Nearly all FST in circulation is bound to activin. FST315 is the major circulating FST isoform but is undetectable in follicular fluid samples aspirated from normal women or women with polycystic ovary syndrome. FST has also biological functions within the gonad and ovary. In follicular fluid, all activin is bioneutralized by FST. FST level increases in the third trimester, with a dramatic increase in the final month, and disap- pears postpartum. FST has been identified also in seminal plasma and was demonstrable in epithelial cells of the seminal vesicle and prostate. Activin regulation by FST has a role in bone repair processes. During endochondral bone formation, activin:FST ratios fluctuate in correlation with chondrocyte maturation and bone cell development.

Cat. No. RD193168200R RUO Other names FS, Activin-binding protein, FST –G

F Product category Bone and cartilage metabolism, Oncology, Reproduction Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.19 to 12 ng/ml Limit of detection 0.03 ng/ml Applications amniotic fluid, serum, plasma (citrate, EDTA) Sample requirements 40 µl/well Storage/Shipping 2-8 °C/ Wet ice

HUMAN FSH ELISA FSH is produced by gonadotrophs of the pituitary together with LH. FSH acts on ovarian follicle in females to cause follicular growth, estrogen production and secretion, and on testicular seminal tubules causing growth and sperm production with the help of androgen in males. FSH secretion is stimulated by a hypothalamic peptide, GnRH.

Cat. No. RCAN-FSH-4060R RUO Other names Follicle Stimulating Hormone Product category Reproduction Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 5 to 100 IU/l Limit of detection 1 IU/l Applications Serum Sample requirements 25 µl/well Storage/Shipping 2-8 °C/ Wet ice

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HUMAN GAD AUTOANTIBODY ELISA Autoantibodies to pancreatic beta cell antigens are important serological markers of type 1 diabetes mellitus (type 1 DM). The antigens recognised by these antibodies include insulin, glutamic acid decarboxylase (GAD65 kDa isoform) and an islet cell antigen IA-2 or ICA-512.

Cat. No. RGDE/96R RUO Other names Glutamic Acid Decarboxylase, GAD65, Anti-GAD, GADAb Product category Diabetology, Autoimmunity Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0 to 2000 U/ml Limit of detection 0.06 U/ml Applications serum Sample requirements 100 μl/well Storage/Shipping –20 °C

HUMAN GALECTIN-3 ELISA Galectin-3 (26 kDa) is a beta-galactoside-binding protein belonging to the Galectin family. Galectin-3 is normally found in epithelia of many organs and various inflammatory cells, including macrophages as well as dendritic cells and Kupfer cells. Galectin-3 has been shown to mediate cell-cell and cell- extracellular matrix interactions, and it acts as a novel chemoattractant for monocytes and macrophages.

Cat. No. RBMS279/2R RUO Other names Galactose specific lectin 3, Mac-2 antigen, 35 kDa lectin, Carbohydrate binding protein 35, Laminin binding protein

Product category Immune Response, Infection and Inflammation IMMUNOASSAYS Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.39 to 25 ng/ml Limit of detection 0.12 ng/ml Applications serum, plasma (EDTA), cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN GDF-15/MIC-1 ELISA Growth differentiation factor 15 (GDF-15) is a member of the transforming growth factor beta (TGF-beta) cytokine superfamily. GDF-15 expression levels in- creased markedly in the heart in mouse models of myocardial infarction and in heart disease. More recent studies of GDF-15 gene-targeted mice indicate that GDF-15 functions as a cardioprotective cytokine during myocardial infarction and heart failure. Increased circulating GDF-15 concentrations have been linked to an enhanced risk of future adverse cardiovascular events in elderly women and it was describe as a new biomarker of the risk of death in patients with non-ST-elevation acute coronary syndrome. GDF-15 is involved in the execution of cell death programs in neurons and tumor cell lines. Serum GDF-15 concentrations increase also in maternal serum with advancing gestation in normal pregnancy. Low GDF-15 concentrations reportedly are associated with an increased risk of preterm labor or miscarriage.

Cat. No. RD191135200R RUO Other names Growth differentiation factor 15 Product category Oncology, Cardiovascular disease, Reproduction Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 70 to 4480 pg/ml Limit of detection 22 pg/ml Applications serum, plasma Sample requirements 30 μl/well Storage/Shipping 2–8 °C/Wet ice

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GHRELIN Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, is synthetized principally in the stomach. It stimulates food intake and trans- duces signals to hypothalamic regulatory nucleid that controls energy homeostasis.

HUMAN GHRELIN ACYLATED ELISA

Cat. No. RA194062400R RUO Other names GHRL, M46, MTLRP Product category Energy metabolism and body weight regulation Assay format Sanwich ELISA, AChE-labelled antibody Calibration range 1.96 to 250 pg/ml Limit of detection 0.3 pg/ml, 0.8 pg/ml (long and short first incubation period) Applications plasma (EDTA-PHMB) Sample requirements 20 μl/well Storage/Shipping -20 °C/Dry ice

RAT GHRELIN ACYLATED ELISA

Cat. No. RD394062400R RUO Other names GHRL, M46, MTLRP Product category Energy metabolism and body weight regulation, Animal studies Assay format Sandwich ELISA AChE-labelled antibody Calibration range 1.96 to 250 pg/ml Limit of detection 0.2 pg/ml, 0.7 pg/ml (long and short first incubation period) Applications plasma (EDTA+PHMB) Sample requirements 20 μl/well Storage/Shipping -20 °C/Dry ice G

HUMAN GHRELIN UNACYLATED ELISA

Cat. No. RA194063400R RUO Other names GHRL, M46, MTLRP Product category Energy metabolism and body weight regulation Assay format Sandwich ELISA AChE-labelled antibody Calibration range 1.96 to 250 pg/ml Limit of detection 0.2 pg/ml, 0.6 pg/ml (long and short first incubation period) Applications plasma (EDTA) Sample requirements 10 μl/well Storage/Shipping -20 °C/Dry ice

RAT GHRELIN UNACYLATED ELISA

Cat. No. RA394063400R RUO Other names GHRL, M46, MTLRP Product category Energy metabolism and body weight regulation, Animal studies Assay format Sandwich ELISA AChE-labelled antibody Calibration range 1.96 to 250 pg/ml Limit of detection 0.6 pg/ml, 0.8 pg/ml (long and short first incubation period) Applications plasma (EDTA) Sample requirements 10 μl/well Storage/Shipping -20 °C/Dry ice

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HUMAN GLIAL FIBRILLARY ACIDIC PROTEIN ELISA GFAP (40-53 kDa), a member of the cytoskeletal protein family, is the principal 8–9 nm intermediate filament in mature astrocytes of the CNS. GFAP is a highly brain specific protein that is not expressed outside the CNS. It is released into the blood soon after traumatic brain injury (TBI). Astrogliosis is characterised by rapid synthesis of GFAP. Thanks to the high brain specificity and early releasing from CNS after TBI, GFAP might be suitable marker for early diagnostics.

Cat. No. RD192072200R RUO Other names GFAP Product category Neural tissue damage markers Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.25 to 25 ng/ml Limit of detection 0.045 ng/ml Applications serum, plasma, cerebrospinal fluid Sample requirements 35 µl/well Storage/Shipping 2–8 °C/Wet ice

RAT GLICENTIN ELISA Glicentin is a 69-amino-acid peptide containing glucagon and oxyntomodulin sequences in the molecule. It is a major form of gut glucagon-like immunore- actants. In mammalian small intestine, proglucagon is processed into glicentin. The physiological role of glicentin is still unclear. It has been known that the circulating level of plasma glicentin-like peptides increases significantly nutrient ingestion.

Cat. No. RSCYK111R RUO Product category Animal studies Assay format Competitive ELISA, Immobilized antibody Calibration range 0.206 to 50 pmol/ml

Applications plasma IMMUNOASSAYS Sample requirements 30 μl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN GLUCAGON ELISA (MULTISPECIES SPECIFICITY) Glucagon (3485 Da) is a 29 amino acid polypeptide. It is an important hormone involved in carbohydrate metabolism. The hormone is synthetised and secreted from alpha cells of the islets of Langerhans, which are located in the endocrine portion of the pancreas. It helps maintain the level of glucose in the blood by binding to glucagon receptors on hepatocytes, causing the liver to release glucose - stored in the form of glycogen - a process known as glycogenolysis. Glucagon encourages the liver to synthesize additional glucose by gluconeogenesis.

Cat. No. RSCYK090R RUO Product category Diabetology, Animal studies Assay format Competitive ELISA, Immobilized antibody Calibration range 50 to 10 000 pg/ml Applications plasma Sample requirements 50 μl or 100 μl/well Storage/Shipping 2–8 °C/Wet ice

GLUCAGON-LIKE PEPTIDE-1 GLP-1 is a peptide hormone from the intestinal mucosa, which is produced from its precursor, proglucagon by post transnational processing. GLP-1 may play a role in the physiological control of feeding. GLP-1 amide was supposed to improve glycemic control in patients with type 2 diabetes by increasing insulin secretion, by inhibiting glucagon secretion and by delaying gastric emptying rather than by altering extrapancreatic glucose metabolism. Intravenous GLP-1 and amide could normalize fasting hyperglycaemia in type 2 diabetic patients. Hyperglycaemia during parenteral nutrition could be controlled by exogenous GLP-1, whereas the chronic therapy of type 2 diabetes required GLP-1 derivatives with longer duration of action.

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HUMAN GLUCAGON-LIKE PEPTIDE-1 ELISA (MULTISPECIES SPECIFICITY)

Cat. No. RSCYK160R RUO Other names GLP-1 Product category Animal studies, Diabetology, Energy metabolism and body weight regulation Assay format Competitive ELISA, Immobilized antibody Calibration range 0.206 to 50 ng/ml Limit of detection 0.206 ng/ml Applications plasma Sample requirements 30 μl/well Storage/Shipping 2–8 °C/Wet ice

MOUSE/RAT GLUCAGON-LIKE PEPTIDE-1 (ACTIVE) ELISA

Cat. No. RSHAKMGP-011R RUO Other names GLP-1 Product category Animal studies, Diabetology, Energy metabolism and body weight regulation Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 1.56 to 50 pg/ml Limit of detection 0.8 pg/ml Applications Serum, Plasma Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

GLUCAGON-LIKE PEPTIDE-2 (GLP-2) The proglucagon gene is expressed in both pancreatic A cells and intestinal L cells. Tissue-specific posttranslational processing of proglucagon by the prohormone convertase produces different proglucagon derived peptides (PGDPs) in both pancreas and intestine. The most notable pancreatic PGDP G is glucagon, whereas the L cell produced several structurally related peptides, including GLP-2. Among PGDPs, GLP-2 has been found to show intestinal epithelial proliferation activity.

HUMAN GLUCAGON-LIKE PEPTIDE-2 ELISA

Cat. No. RSCYK141R RUO Other names GLP-2 Product category Diabetology Assay format Competitive ELISA, Immobilized antibody Calibration range 0.412 to 100 ng/ml Applications serum, plasma Sample requirements 25 μl/well Storage/Shipping 2–8 °C/Wet ice

MOUSE GLUCAGON-LIKE PEPTIDE-2 ELISA

Cat. No. RSCYK142R RUO Other names GLP-2 Product category Diabetology, Animal studies Assay format Competitive ELISA, Immobilized antibody Calibration range 0.412 to 100 ng/ml Limit of detection 0.137 ng/ml Applications serum, plasma Sample requirements 25 μl/well Storage/Shipping 2–8 °C/Wet ice

114 For more information please go to www.biovendor.com IMMUNOASSAYS

RAT GLUCAGON-LIKE PEPTIDE-2 ELISA

Cat. No. RSCYK140R RUO Other names GLP-2 Product category Diabetology, Animal studies Assay format Competitive ELISA, Immobilized antibody Calibration range 0.137 to 100 ng/ml Applications serum, plasma Sample requirements 25 μl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN GLUTATHIONE PEROXIDASE 1 ELISA

Cat. No. RAG012R RUO Other names Gpx1 Product category Oxidative stress Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.0625 to 4 ng/ml Limit of detection 45 pg/ml Applications Plasma Storage/Shipping 2–8 °C/Wet ice IMMUNOASSAYS HUMAN GLUTATHIONE PEROXIDASE 1 (INTRACELLULAR) ELISA

Cat. No. RAG013R RUO Other names Gpx1 Product category Oxidative stress Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.063 to 4 ng/ml Limit of detection 45 pg/ml Applications Cell lysate Storage/Shipping 2–8 °C/Wet ice

GM-CSF GM-CSF is a small glycoprotein growth factor which stimulates the production and function of neutrophils, eosinophils and monocytes. It can be produced by a wide variety of tissue types. The biological effects of GM-CSF are mediated through its binding to cell surface receptors, which appear to be widely expressed by thermatopoietic cells and also by some non-thermatopoietic cells, such as endothelial cells.

HUMAN GM-CSF ELISA

Cat. No. RBMS283R RUO Other names Granulocyte-macrophage colony stimulating factor, Molgramostin, Sargramostim, Colony-stimulating factor Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 7.8 to 500 pg/ml Limit of detection 2.9 pg/ml Applications serum, amniotic fluid, plasma, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

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MOUSE GM-CSF ELISA

Cat. No. RBMS612R RUO Other names Granulocyte-macrophage colony stimulating factor, Molgramostin, Sargramostim, Colony-stimulating factor Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 3.9 to 250 pg/ml Limit of detection 1.98 pg/ml Applications serum, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

RAT GM-CSF ELISA

Cat. No. RBMS633R RUO Other names Granulocyte-macrophage colony stimulating factor, Molgramostin, Sargramostim, Colony-stimulating factor Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 7.8 to 500 pg/ml Limit of detection 3.5 pg/ml Applications serum, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN GM-CSF RECEPTOR α CHAIN (CD116) ELISA GM-CSF Receptor alpha is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, dif- ferentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the G pseudoautosomal region of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble.

Cat. No. RGP004R RUO Other names Cluster of differentiation 116, Granulocyte-macrophage colony stimulating factor, Molgramostin, Sargramostim, Colony-stimulat- ing factor Product category Cell surface proteins (sCD), Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 31.25 to 1000 pg/ml Limit of detection < 16 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 100 µl/well Storage/Shipping 2-8 °C/ Wet ice

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GRANZYME Granzymes are exogenous serine proteinases (enzymes) that are released from cytoplasmic granules of cytotoxic lymphocytes and NK cells. Percentages of the Granzyme A and B positive CTLs can be determined by flow cytometry and immunocytochemical methods for many disorders (viral infections, lympho- mas, carcinomas, rheumatoid arthritis and transplantation).

HUMAN GRANZYME A ELISA

Cat. No. RBMS2026R RUO Other names Cytotoxic T-lymphocyte proteinase 1, Hanukkah factor, CTL tryptase, Fragmentin 1, T-lymphocyte associated serine esterase 3 Product category Immune Response, Infection and Inflammation, Apoptosis,Transplantation Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.8 to 600 pg/ml Limit of detection 0.4 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping –20 °C

HUMAN GRANZYME B ELISA

Cat. No. RBMS2027R RUO Other names Granzyme 2, Human lymphocyte protein, Fragmentin 2 Product category Apoptosis, Immune Response, Infection and Inflammation Assay format Sandwich ELISA, Biotin-labelled antibody IMMUNOASSAYS Calibration range 0.7 to 480 pg/ml Limit of detection 0.2 pg/ml Applications serum, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping –20 °C

GROWTH HORMONE Human growth hormone (hGH) is the product of the GH-1 gene located on chromosome 17 and expressed in pituitary cells. Bioactivity of GH is regulated by a specific binding protein formed by the extra cellular part of the cellular transmembrane GH-receptor. In children and adolescent, the hGH system is the main regulator of growth. It has a lipolytic effect too. GH deficiency shows disease pattern, equivalent to advanced aging.

HUMAN GROWTH HORMONE ELISA

Cat. No. RCAN-GH-4070R RUO Other names GH Product category Growth hormone and factor-related products Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 1 to 50 ng/ml Limit of detection 0.2 ng/ml Applications Serum Sample requirements 25 µl/well Storage/Shipping 2–8 °C/Wet ice

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HUMAN GROWTH HORMONE SENSITIVE ELISA

Cat. No. RMEE022 IVD CE Other names GH Product category Growth hormone and factor-related products Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 50 to 1 000 pg/ml Limit of detection 1.66 pg/ml Applications serum, plasma Sample requirements 100 μl/well Storage/Shipping 2–8 °C/Wet ice

RAT GROWTH HORMONE ELISA

Cat. No. RSHAKRGH-010R RUO Other names GH Product category Growth hormone and factor-related products, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 31.3 – 2000 pg/ml Limit of detection 16 pg/ml Applications serum, plasma Sample requirements 5 μl/well Storage/Shipping 2–8 °C/Wet ice

RAT HEMOGLOBIN ELISA Hemoglobing is the iron-containing oxygen-transport metalloprotein in the red blood cells. It transports oxygen from the lungs or gills to the rest of the

–I body, such as to the muscles, where it releases its load of oxygen. Examination of occult blood in urine is used as a screening test for hemorrhagic lesion

G of gastrointestinal tract and renal disturbance.

Cat. No. RSCPRC031R RUO Other names Hb Product category Animal studies Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0 to 80 ng/ml Applications urine Sample requirements 100 μl/well Storage/Shipping 2–8 °C/Wet ice

118 For more information please go to www.biovendor.com IMMUNOASSAYS

HUMAN sHER-2 ELISA The human HER-2 gene encodes a putative transmembrane growth factor receptor (p185 protein) that is closely related to the epidermal growth factor receptor protein. The HER-2 gene product is a 185 kDa glycoprotein that contains an extracellular ligand-binding domain and intracellular tyrosine kinase activity. HER-2 protein staining is observed only in low levels in epithelial cells of most organs in normal human tissues and at slightly higher levels in fetal tissues. HER-2 protein is useful in identifying cancer cells with increased aggressiveness.

Cat. No. RBMS207R RUO Other names ERBB2, C-erb B2, Herstatin, NEU-protooncogene Product category Oncology Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.16 to 10 ng/ml Limit of detection 0.06 ng/ml Applications serum, plasma (EDTA, heparin), amniotic fluid, cell culture supernatant Sample requirements 100 µl/well (1:20 prediluted) Storage/Shipping 2–8 °C/Wet ice sHLA-G ELISA sHLA-G is an immunosuppressive molecule inducing apoptosis of activated CD8(+) T cells and down-modulating CD4(+) T cell proliferation. sHLA-G ELISA can be a useful biochemical assay in addition to embryo morphology in embryo selection for transfer in in vitro fertilization treatment. Monitoring of sHLA-G in amniotic fluid and plasma of pregnant women may have an important prognostic value to recognize pathological situations. Analysis of HLA-G molecules should be taken into consideration when monitoring transplant-patients status.

Cat. No. RD194070100R RUO Product category Immune Response, Infection and Inflammation, Reproduction, Transplantation IMMUNOASSAYS Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 3.91 to 125 U/ml Limit of detection 0.6 U/ml Applications Amniotic fluid, Cell culture supernatant, Plasma-EDTA Sample requirements 25 μl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN IA-2 AUTOANTIBODY ELISA Autoantibodies to pancreatic beta cell antigens are important serological markers of type 1 diabetes mellitus (type 1 DM). The antigens recognised by these antibodies include insulin, glutamic acid decarboxylase (GAD65 kDa isoform) and an islet cell antigen IA-2 or ICA-512.

Cat. No. RIAE/96R RUO Other names IA-2 Ab, Insulinoma associated antigen 2 Product category Diabetology, Autoimmunity Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 7.5 to 4000 U/ml Limit of detection 0.15 U/ml Applications serum Sample requirements 100 μl/well Storage/Shipping 2–8 °C/Wet ice

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ICAM-1 ICAM-1 (55 kDa) is a member of the immunoglobulin supergene family that functions as a ligand for the Lymphocyte Function-Associated Antigen-1. It is a single-chain glycoprotein that can be expressed on non-hematopoietic cells of many lineages. The role of ICAM-1 as a disease marker has been demon- strated for a number of different indications and pathological situations. ICAM-1 upregulation in allergic airway inflammation is responsible for the recruit- ment of activated leukocytes and the pathogenesis of allergic rhinitis. In lymphoproliferative disorders, ICAM-1 is related to the degree of malignancy.

HUMAN sICAM-1 ELISA

Cat. No. RBMS201R RUO Other names Intercellular adhesion molecule 1, CD54 antigen Product category Cell adhesion proteins Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 6.25 to 100 ng/ml Limit of detection 2.2 ng/ml Applications serum, plasma, cell culture supernatant Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

MONKEY sICAM-1 ELISA

Cat. No. RBMS648R RUO Other names Intercellular adhesion molecule 1, Major group rhinovirus receptor, CD54 antigen, Surface antigen of activated B cells Product category Cell adhesion proteins, Animal studies Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 6.25 to 100 U/ml Limit of detection 1.05 U/ml Applications baboon serum, rhesus serum

I Sample requirements 25 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN sICAM-2 ELISA ICAM-2 (60 kDa) is a surface glycoprotein that promotes adhesion between immune cells and the vascular endothelium. ICAM-2 is a member of the Ig-superfamily with two immunoglobulin-like extracellular domains. It is distributed on hematopoietic cells. ICAM-2 dominates over ICAM-1 in resting endothelial cells and seems to be involved in the recirculation of LFA-1 positive lymphocytes ( e.g. facilitating T-memory cell recirculation). As resting T-cells express little or no ICAM-1, ICAM-2 may also be important in initial T-cell adhesion with antigen-presenting cells that bear LFA-1.

Cat. No. RBMS236R RUO Other names Intercellular adhesion molecule 2, CD102 antigen Product category Cell adhesion proteins Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.75 to 24 U/ml Limit of detection 0.30 U/ml Applications serum, plasma, urine, amniotic fluid, cell culture supernatant, whole blood Sample requirements 100 µl/well (1:20 prediluted) Storage/Shipping 2–8 °C/Wet ice

120 For more information please go to www.biovendor.com IMMUNOASSAYS

HUMAN sICAM-3 ELISA ICAM-3 is a member of the immunoglobulin supergene family and functions as a ligand for the Lymphocyte Function-Associated Antigen-1. ICAM-3 is a heavily glycosylated protein of 124 kDa with a polypeptide core of 57 kDa. ICAM-3 is absent in endothelia. It is expressed on resting lymphocytes, mono- cytes and neutrophils, representing the major LFA-1 ligand on these cells. ICAM-3 is a very interesting molecule involved in the initial immune response, thus suggesting an important role as a disease marker for a number of different indications and pathological situations.

Cat. No. RBMS218R RUO Other names Intercellular adhesion molecule 3, CD50 antigen Product category Cell adhesion proteins Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.78 to 50 ng/ml Limit of detection 0.38 ng/ml Applications serum, plasma (EDTA, heparin), urine, amniotic fluid, cell culture supernatant Sample requirements 20 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN IFN-ALPHA ELISA IFNα (about 19 kDa, 166 amino acid residues) belongs to class I interferon. The interferons exhibit a huge number of biological effects. On purification of the natural human leukocyte interferons, it was found that all fractions that exhibited antiviral activity also exhibited anti-growth activity. Serum IFNα levels can help to distinguish between children with non-specific abdominal pain or mesenteric adenitis, and those with acute appendicitis. Increased levels of IFNα were found in the majority of patients suffering from inflammatory arthropathies.

Cat. No. RBMS216R RUO Other names Alpha interferon, IFN leukocytic, LeIF D Product category Cytokines, chemokines and related molecules IMMUNOASSAYS Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 7.8 to 500 pg/ml Limit of detection 3.16 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 20 µl/well Storage/Shipping 2–8 °C/Wet ice

IFN-GAMMA IFNγ is a homodimeric glycoprotein containing approximately 21 to 24 kD subunits. Production of IFNγ is a function of T cells and NK cells. IFNγ is pro- duced during infection by T cells of the cytotoxic/sup­pressor phenotype (CD8) and by a subtype of helper T cells, the Th1 cells. IFNγ is a diagnostic tool for distinguishing tuberculous from other nontuberculous ascites. It is important in the design and monitoring of immunotherapy for multiple sclerosis.

HUMAN IFN-GAMMA ELISA

Cat. No. RBMS228R RUO Other names Immune interferon Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 1.6 to 100 pg/ml Limit of detection 0.99 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

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HUMAN IFN-GAMMA ELISA, HIGH SENSITIVITY

Cat. No. RGP010R RUO Other names Immune interferon Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.78 to 25 pg/ml Limit of detection < 0.69 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 100 µl/well Storage/Shipping 2-8 °C/ Wet ice

MOUSE IFN-GAMMA ELISA

Cat. No. RBMS606R RUO Other names Immune interferon Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 15.6 to 1000 pg/ml Limit of detection 5.3 pg/ml Applications serum, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

PIG IFN-GAMMA ELISA

I Cat. No. RBMS671R RUO Other names Immune interferon Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 31.3 to 2000 pg/ml Limit of detection 3.3 pg/ml Applications serum, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

RAT IFN-GAMMA ELISA

Cat. No. RBMS621R RUO Other names Immune interferon Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 31.3 to 2000 pg/ml Limit of detection 9.9 pg/ml Applications serum, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

122 For more information please go to www.biovendor.com IMMUNOASSAYS

HUMAN IFN-OMEGA ELISA IFNω belongs to class I interferon. In the human genome, the IFNω gene family consists of seven members located on chromosome 9. IFNω is a major component of human leukocyte IFN. Therapeutically administered IFNω may cause measurable serum concentrations in the corresponding patients. Moni- toring of these IFNω serum levels provides an important tool in therapy.

Cat. No. RBMS233R RUO Other names Interferon alpha-II-1 Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 4.7 to 300 pg/ml Limit of detection 1.51 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 25 µl/well Storage/Shipping 2–8 °C/Wet ice

IGF-1 IGF-1 (7649 Da) is a polypeptide protein hormone consisting of 70 amino acids. It is produced primarily by the liver as an endocrine hormone as well as target tissues in a paracrine/autocrine fashion. IGF-1 play a pivotal role in regulating the proliferation, differentiation and specific functions of many cell types.

HUMAN IGF-1 ELISA

Cat. No. RMEE20 IVD CE

Other names Insulin-Like Growth Factor 1 IMMUNOASSAYS Product category Growth hormone and factor-related products Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 1 to 50 ng/ml Limit of detection 0.09 ng/ml Applications serum, plasma Sample requirements 20 μl/well Storage/Shipping 2–8 °C/Wet ice

MOUSE/RAT IGF-1 ELISA

Cat. No. RMEE25R RUO Other names Insulin-Like Growth Factor-1 Product category Growth hormone and factor-related products Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.5 to 18 ng/ml Limit of detection 0.029 ng/ml Applications serum Sample requirements 50 μl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN IGF-2 ELISA

Cat. No. RMEE30 IVD Other names Insulin-Like Growth Factor 2 Product category Growth hormone and factor-related products Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.02 to 3600 ng/ml Limit of detection 0.02 ng/ml Applications Serum, Plasma Sample requirements Storage/Shipping 2–8 °C/Wet ice [email protected] 123 IMMUNOASSAYS

IGFBP-1 Insulin-like growth factor binding protein-1 (IGFBP-1) is one of six proteins that specifically bind insulin-like growth factors I and II (IGF-I and IGF-II) in body fluids and tissues. IFGBP-1 contains 234 amino acids, with a predicted molecular mass of 25 kDa. The major sites of IGFBP-1 synthesis are the fetal / adult liver and decidualized endometrium. Serum levels of IGFBP-1, which reflect its synthesis by the liver, exhibit considerable diurnal variation. Circulating IGFBP-1 levels are highest early in the morning and lowest in the evening. The levels are high in the fetus and newborn, but decline steadily until puberty. The mean level of IGFBP-1 in healthy adults is 4.4 μg/L (range 0.6–14.4 μg/L). After about 65 years of age, serum IGFBP-1 levels begin to increase. There is also an inverse correlation between body mass index (BMI) and fasting serum IGFBP-1 concentrations. The most important regulator of circulating IGFBP-1 is insulin. Fasting insulin and IGFBP-1 concentrations are inversely correlated. During a 3-h glucose tolerance test, there is a decrease of about 50% in serum IFGBP-1 levels. Eating a meal also has a decreasing effect. In insulin-dependent diabetes (IDDM), serum IGFBP-1 levels are elevated. In non-insulin dependent diabetes, in which insulin levels are high, serum IGFBP-1 is decreased. Low levels of IGFBP-1 have also been observed in the follow- ing cases: acromegaly, Cushing’s syndrome and polysystic ovarian syndrome (PCO).

HUMAN IGFBP-1 ELISA

Cat. No. RMEE01 IVD CE Other names Insulin-Like Growth Factor Binding Protein-1 Product category Growth hormone and factor-related products Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0 to 8 ng/ml Limit of detection 0.02 ng/ml Applications serum, cell culture medium, urine, amniotic fluid, milk, saliva Sample requirements 2 pg/well Storage/Shipping 2–8 °C/Wet ice

HUMAN IGFBP-1 ELISA

Cat. No. RCAN-IGF-4140R RUO Other names Insulin-Like Growth Factor Binding Protein-1 Product category Growth hormone and factor-related products

I Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 1 to 250 µg/l Limit of detection 0.5 µg/l Applications Serum Sample requirements 25 µl/well Storage/Shipping 2–8 °C/Wet ice

IGFBP-2 IGFBP-2 is a unglycosylated polypeptide of 31.3 kDa, which forms binary IGF-complexes and shows no circadian rhythm in the circulation. At cellular level IGFBP-2 seems to stimulate the proliferation and dissemination of solid tumors via an IGF-independent mechanism.

HUMAN IGFBP-2 ELISA

Cat. No. RMEE05R RUO Other names Insulin-Like Growth Factor Binding Protein-2 Product category Growth hormone and factor-related products Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 1 to 80 ng/ml Limit of detection 0.2 ng/ml Applications serum, urine, amniotic fluid, milk, saliva Sample requirements 15 μl/well Storage/Shipping 2–8 °C/Wet ice

124 For more information please go to www.biovendor.com IMMUNOASSAYS

MOUSE/RAT IGFBP-2 ELISA

Cat. No. RMEE08R RUO Other names Insulin-Like Growth Factor Binding Protein-2 Product category Growth hormone and factor-related products, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.031 to 2 ng/ml Limit of detection 0.01 ng/ml Applications serum Sample requirements 10 μl/well Storage/Shipping 2–8 °C/Wet ice

IGFBP-3 IGFBP-3 has proved to be an additional useful test in the repertoire of diagnostic tools for evaluation of growth disorders. Patients with growth hormone deficiency have subnormal total IGFBP-3 levels.

HUMAN IGFBP-3 FUNCTIONAL ELISA

Cat. No. RMEE04R RUO Other names Insulin-Like Growth Factor Binding Protein-3 Product category Growth hormone and factor-related products Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 2 to 150 ng/ml IMMUNOASSAYS Limit of detection 0.18 ng/ml Applications serum, plasma Sample requirements 10 μl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN IGFBP-3 TOTAL ELISA

Cat. No. RMEE03A IVD CE Other names Insulin-Like Growth Factor Binding Protein-3 Product category Growth hormone and factor-related products Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.4 to 30 ng/ml Limit of detection 0.1 ng/ml Applications erum, plasma (heparin), cerebrospinal fluid Storage/Shipping 2–8 °C/Wet ice

MOUSE/RAT IGFBP-3 ELISA

Cat. No. RMEE031R RUO Other names Insulin-Like Growth Factor Binding Protein-3 Product category Growth hormone and factor-related products, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.078 to 5 ng/ml Limit of detection 0.018 ng/ml Applications serum, cell lysates, nuclear extracts Sample requirement 5 μl/well Storage/Shipping 2–8 °C/Wet ice

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HUMAN IMMUNOGLOBULIN A (SECRETORY) IN STOOL ELISA Secretory IgA is comprised of two immunoglobuline A molecules, which are joined by a J-protein and secretory component. The secretory component is synthesized by epithelial cells of the mucous membrane of gastrointestinal, respiratory and urogenitaltract. It is also produced by the saliva, tear and mam- mary glands. The determination of sIgA allows a first overview of the functionality of the gastrointestinal associated immune system.

Cat. No. RIC6100 IVD CE Other names sIgA, IgA Secretory Product category Immune Response, Infection and Inflammation, Autoimmunity Assay format Sandwich ELISA, HRP-labelled antibody Limit of detection 3.1 ng/ml Applications stool, saliva Sample requirements 100 µl/well Storage/Shipping 2–8 °C/Wet ice

IMMUNOGLOBULIN E IgE plays an important role in allergy, and is especially associated with type 1 hypersensitivity. It may be an important target in treatments for asthma.

MOUSE IMMUNOGLOBULIN E ELISA

Cat. No. RSHAKRIE010R RUO Other names IgE Product category Autoimmunity , Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 1 to 100 ng/ml Limit of detection 50 pg/ml Applications serum, plasma Sample requirements 5 μl/well I Storage/Shipping 2–8 °C/Wet ice

RAT IMMUNOGLOBULIN E ELISA

Cat. No. RSHAKRIE011R RUO Other names IgE Product category: Autoimmunity, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 1 to 100 ng/ml Limit of detection 0.25 ng/ml Applications serum, plasma Sample requirements 5 μl/well Storage/Shipping 2–8 °C/Wet ice

126 For more information please go to www.biovendor.com IMMUNOASSAYS

HUMAN IMMUNOGLOBULIN FREE LIGHT CHAINS ELISA FLC are a natural product of B lymphocytes and represent a biomarker of neoplastic and reactive B cell-related disorders. In serum, FLC kappa (22.5 kDa) exists as a monomer and FLC lambda (45 kDa) as a dimer. Low levels of FLCs are found in serum of normal individuals due to their excess production over heavy chains by mature B-cells. The detection of the FLCs is important diagnostic aid for a variety of monoclonal gammopathies. Measurement of monoclo- nal FLCs is important in light-chains diseases, such as light-chain myeloma, primary systemic amyloidosis, and light chain-deposition disease. The ability to quantify monoclonal FLCs may be useful to monitor the disease. The detection of urinary monoclonal FLCs is important for identifying and monitoring B‑cell malignancies too.

Cat. No. RD194088100R RUO Other names FLC Product category Oncology, Autoimmunity Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 10 to 320 µg/l (FLC Kappa), 17.5 to 560 µg/l (FLC Lambda) Limit of detection 6 µg/l (FLC Kappa), 5 µg/l (FLC Lambda) Applications serum, plasma, urine Sample requirements 2x5 μl/well Storage/Shipping 2–8 °C/Wet ice

INSULIN Insulin (5808 Da) is a peptide hormone composed of 2 peptide chains of totally 51 amino acid residues. It is produced in the Islets of Langerhans in the pancreas. In beta cells, insulin is synthesized from the proinsulin precursor molecule by the action of proteolytic enzymes, known as prohormone convertases, as well as the exoprotease carboxypeptidase E. Insulin is used to treat some forms of diabetes mellitus. Its principal function is to control the uptake and utilisation of glucose in peripheral tissue via the glucose transporter. This and other hypoglycaemic activities, such as the inhibition of hepatic gluconeogenesis and glycogenolysis are counteracted by the hyperglycaemic hormones including glucagon, epinephrine (adrenaline), growth hormone and cortisol. IMMUNOASSAYS

CANINE INSULIN ELISA

Cat. No. RSHAKRIN012TR RUO Product category Diabetology, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 188 to 12 000 pg/ml Limit of detection 13 pg/ml Applications serum, plasma Sample requirements 10 μl/well Storage/Shipping 2–8 °C/Wet ice

HAMSTER INSULIN STANDARD

Cat. No. RSHASIN-001R RUO Product category Diabetology, Animal studies Size 5 × 250 µl Storage/Shipping 2–8 °C/Wet ice

HUMAN INSULIN ELISA

Cat. No. RIS006R RUO Product category Diabetology Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 5.1 to 250 µIU/ml Limit of detection 0.17 µIU/ml Applications Serum Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

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HUMAN INSULIN ELISA (MULTISPECIES SPECIFICITY)

Cat. No. RSCYK060R RUO Product category Diabetology, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.137 to 100 ng/ml Applications serum Sample requirements 25 μl/well Storage/Shipping 2–8 °C/Wet ice

MOUSE INSULIN (H-TYPE) ELISA

Cat. No. RSHAKRIN011HR RUO Product category Diabetology, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 500 to 100 000 pg/ml Limit of detection 25 pg/ml Applications serum, plasma, culture medium Sample requirements 10 μl/well Storage/Shipping 2–8 °C/Wet ice

MOUSE INSULIN (RTU) ELISA

Cat. No. RSHAKRIN-011RUR RUO Product category Diabetology, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody

I Calibration range 100 to 12000 pg/ml Applications Culture medium, Plasma, Serum Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

MOUSE INSULIN (S-TYPE) ELISA

Cat. No. RSHAKRIN011SR RUO Product category Diabetology, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 78 to 5 000 pg/ml Limit of detection 3.9 pg/ml Applications serum, plasma, cell culture medium Sample requirements 5 μl/well Storage/Shipping 2–8 °C/Wet ice

MOUSE INSULIN (TMB) ELISA

Cat. No. RSHAKRIN011TR RUO Product category Diabetology, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 156 to 10 000 pg/ml Limit of detection 7.8 pg/ml Applications serum, plasma, cell culture medium Sample requirements 10 μl/well Storage/Shipping 2–8 °C/Wet ice

128 For more information please go to www.biovendor.com IMMUNOASSAYS

MOUSE INSULIN (U-TYPE) ELISA

Cat. No. RSHAKRIN031R RUO Product category Diabetology, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 39 to 2 500 pg/ml Limit of detection 3.9 pg/ml Applications serum, plasma, cell culture medium Sample requirements 5 µl/well Storage/Shipping 2–8 °C/Wet ice

PORCINE INSULIN ELISA

Cat. No. RSHAKRIN013TR RUO Product category Diabetology, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 188 to 12000 pg/ml Limit of detection 13 pg/ml Applications serum, plasma Sample requirements 10 μl/well Storage/Shipping 2–8 °C/Wet ice

RAT INSULIN (H-TYPE) ELISA IMMUNOASSAYS

Cat. No. RSHAKRIN010HR RUO Product category Diabetology, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 500 to 100 000 pg/ml Limit of detection 25 pg/ml Applications serum, plasma, cell culture medium Sample requirements 10 μl/well Storage/Shipping 2–8 °C/Wet ice

RAT INSULIN (RTU) ELISA

Cat. No. RSHAKRIN-010RUR RUO Product category Diabetology, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 100 to 12000 pg/ml Applications Culture medium, Plasma, Serum Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

RAT INSULIN (S-TYPE) ELISA

Cat. No. RSHAKRIN010SR RUO Product category Diabetology, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 100 to 10 000 pg/ml Limit of detection 5.0 pg/ml Applications serum, plasma, cell culture medium Sample requirements 10 μl/well Storage/Shipping 2–8 °C/Wet ice

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RAT INSULIN (TMB) ELISA

Cat. No. RSHAKRIN010TR RUO Product category Diabetology, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 156 to 10 000 pg/ml Limit of detection 7.8 pg/ml Applications serum, plasma, cell culture medium Sample requirements 10 μl/well Storage/Shipping 2–8 °C/Wet ice

RAT INSULIN (U-E TYPE) ELISA

Cat. No. RSHAKRIN130R RUO Product category Diabetology, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 39 to 2 500 pg/ml Limit of detection 3.9 pg/ml Applications serum, plasma, cell culture medium Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

INTERLEUKIN-1ALPHA (IL-1α) IL-1α is predominantly a cell-associated, non-secreted proinflammatory cytokine. It is produced in a variety of cells including monocytes, tissue mac- rophages, keratinocytes and other epithelial cells. High levels of IL-1α are associated with sepsis, rheumatoid arthritis, inflammatory bowel disease, acute and chronic myelogenous leukemia, insulin-dependent diabetes mellitus, and atherosclerosis. I HUMAN INTERLEUKIN-1 ALPHA ELISA

Cat. No. RBMS243/2R RUO Other names IL-1α, Hematopoietin 1, IL-1F1 Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 1.6 to 100 pg/ml Limit of detection 1.6 pg/ml Applications serum, plasma, cell culture supernatant, urine Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

MOUSE INTERLEUKIN-1 ALPHA ELISA

Cat. No. RBMS611R RUO Other names IL-1α, Hematopoietin 1, IL-1F1 Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 7.8 to 500 pg/ml Limit of detection 4.0 pg/ml Applications serum, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

130 For more information please go to www.biovendor.com IMMUNOASSAYS

RAT INTERLEUKIN-1 ALPHA ELISA

Cat. No. RBMS627R RUO Other names IL-1α, Hematopoietin 1, IL-1F1 Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 15.6 to 1000 pg/ml Limit of detection 4.0 pg/ml Applications serum, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN INTERLEUKIN-1RA ELISA

Cat. No. RBMS2080R RUO Other names Interleukin-1 receptor antagonist Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 109 to 7000 pg/ml Limit of detection 30 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 50 µl/well

Storage/Shipping 2–8 °C/Wet ice IMMUNOASSAYS

INTERLEUKIN-1 BETA ELISA (IL-1β) IL-1β is expressed by a variety of cells including macrophages, monocytes, platelets and neutrophils. IL-1β is a potent immunomodulator, mediating a wide range of immune and inflammatory responses including the activation of B and T cells.

HUMAN INTERLEUKIN-1 BETA ELISA

Cat. No. RBMS224/2R RUO Other names IL-1β, Catabolin, IL-1F2 Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 3.9 to 250 pg/ml Limit of detection 0.3 pg/ml Applications serum, plasma (heparin, citrate), cell culture supernatant, urine Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

MONKEY INTERLEUKIN-1 BETA ELISA

Cat. No. RBMS645R RUO Other names IL-1ß, Catabolin, IL-1F2 Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 6.25 to 400 U/ml Limit of detection 0.66 U/ml Applications baboon serum, cynomolgus serum Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

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MOUSE INTERLEUKIN-1 BETA ELISA

Cat. No. RBMS6002R RUO Other names IL-1ß, Catabolin, IL-1F2 Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 7.8 to 500 pg/ml Limit of detection 1.2 pg/ml Applications serum, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

RAT INTERLEUKIN-1 BETA ELISA

Cat. No. RBMS630R RUO Other names IL-1ß, Catabolin, IL-1F2 Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 31.3 to 2000 pg/ml Limit of detection 4.0 pg/ml Applications serum, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

INTERLEUKIN-2 Interleukin-2 plays a central role in the activation and proliferation of lymphocytes that have been primed by antigens. IL-2 plays a pivotal role in the expan-

I sion of most T-cells, natural killer cells and B cells during certain phases of their response.

HUMAN INTERLEUKIN-2 ELISA

Cat. No. RBMS221R RUO Other names IL-2, Aldesleukin, T cell growth factor, TCGF Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 18.8 to 1200 pg/ml Limit of detection 9.9 pg/ml Applications serum, plasma, cell culture supernatant, urine, amniotic fluid, white blood Sample requirements 100 µl Storage/Shipping 2–8 °C/Wet ice

HUMAN INTERLEUKIN-2 ELISA, HIGH SENSITIVITY

Cat. No. RGP011R RUO Other names IL-2, Aldesleukin, T cell growth factor, TCGF Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 1.87 to 60 pg/ml Limit of detection 0.97 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 100 µl/well Storage/Shipping 2-8 °C/ Wet ice

132 For more information please go to www.biovendor.com IMMUNOASSAYS

MONKEY INTERLEUKIN-2 ELISA

Cat. No. RBMS643R RUO Other names IL-2, Aldesleukin, T cell growth factor, TCGF Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 18.8. to 1200 pg/ml Limit of detection 9.1 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

MOUSE INTERLEUKIN-2 ELISA

Cat. No. RBMS601R RUO Other names IL-2, Aldesleukin, T cell growth factor, TCGF Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 15.6 to 1000 pg/ml Limit of detection 5.3 pg/ml Applications serum, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice IMMUNOASSAYS

RAT INTERLEUKIN-2 ELISA

Cat. No. RBMS634R RUO Other names IL-2, Aldesleukin, T cell growth factor, TCGF Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 62.5 to 2000 pg/ml Limit of detection 11.0 pg/ml Applications serum, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN sINTERLEUKIN-2 RECEPTOR ELISA The receptor of the cytokine IL-2 plays a crucial role in the regulation of the immune response. Binding of IL-2 to its receptor (IL-2R) on the surface of T-lymphocytes triggers a series of intracellular signaling events that result in the activation and proliferation of resting T cells and in the generation of helper, suppressor and cytotoxic T cells, which mediate immune reactions. sIL-2R is a marker for T cell activation. It can be an indicator of a wide spectrum of disorders involving immune activation. IL2R can be found at significantly elevated levels in a broad range of disorders such as tumor diseases, autoimmune diseases (e.g. sarcoidosis), organ rejection and various infections.

Cat. No. RBMS212/2R RUO Other names IL-2R, CD25 antigen Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.31 to 20 ng/ml Limit of detection 0.27 ng/ml Applications serum, plasma, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

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INTERLEUKIN-4 IL-4 (15 to 19 kDa) is produced by a variety of T cell thymocyte populations, as well as some mast cell precursors that are non-T or B cell types. IL-4 plays an important role in the activation of resting B-cells and in the subsequent proliferation and differentiation of B-cells. IL-4 is essential for IgE synthesis in vitro and its involvement with allergic diseases has been investigated. IL-4 has the anti-inflammatory effects.

HUMAN INTERLEUKIN-4 ELISA

Cat. No. RBMS225/2R RUO Other names IL-4, B-cell stimulatory factor 1, Lymphocyte stimulatory factor 1 Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 7.8 to 500 pg/ml Limit of detection 1.3 pg/ml Applications serum, plasma, cell culture supernatant, urine Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN INTERLEUKIN-4 ELISA, HIGH SENSITIVITY

Cat. No. RGP012R RUO Other names IL-4, B-cell stimulatory factor 1, Lymphocyte stimulatory factor 1 Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.31 to 10 pg/ml Limit of detection 0.31 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 100 µl/well I Storage/Shipping 2-8 °C/ Wet ice

MOUSE INTERLEUKIN-4 ELISA

Cat. No. RBMS613R RUO Other names IL-4, B-cell stimulatory factor 1, Lymphocyte stimulatory factor 1 Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 3.9 to 250 pg/ml Limit of detection 1.98 pg/ml Applications serum, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

RAT INTERLEUKIN-4 ELISA

Cat. No. RBMS628R RUO Other names IL-4, B-cell stimulatory factor 1, Lymphocyte stimulatory factor 1 Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 1.6 to 100 pg/ml Limit of detection 0.2 pg/ml Applications serum, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

134 For more information please go to www.biovendor.com IMMUNOASSAYS

HUMAN INTERLEUKIN-4 RECEPTOR (CD124) ELISA

Cat. No. RGP006R RUO Other names sIL-4R, Cluster of differentiation 124 Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 31.25 to 1000 pg/ml Limit of detection < 11.5 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 100 µl/well Storage/Shipping 2-8 °C/ Wet ice

INTERLEUKIN-5 IL-5 is produced by lymphocytes as a glycosylated, disulfide-linked homodimer. Inflammatory-induced and locally produced IL-5 may act on the bone mar- row in a cooperative manner.

HUMAN INTERLEUKIN-5 ELISA

Cat. No. RBMS278R RUO Other names IL-5, T-cell replacing factor, Eosinophil differentiation factor, B cell differentiation factor I, T cell replacing factor Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 7.8 to 500 pg/ml IMMUNOASSAYS Limit of detection 1.5 pg/ml Applications serum, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

MOUSE INTERLEUKIN-5 ELISA

Cat. No. RBMS610R RUO Other names IL-5, T-cell replacing factor, Eosinophil differentiation factor, B cell differentiation factor I, T cell replacing factor Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 7.8 to 500 pg/ml Limit of detection 3.3 pg/ml Applications serum, cell culture supernatant Sample requirements 50 µl Storage/Shipping 2–8 °C/Wet ice

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INTERLEUKIN-6 Interleukin-6 is a multi-functional cytokine that regulates immune responses, acute phase reactions and hematopoiesis, and it may play a central role in host defense mechanisms. IL-6 is usually not produced constitutively by normal cells, but its expression is readily induced by a variety of cytokines, lipopolysaccharide or viral infections.

HUMAN INTERLEUKIN-6 ELISA

Cat. No. RBMS213/2R RUO Other names IL-6, interferon-beta 2, B-cell stimulatory factor 2 Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 1.56 to 100 pg/ml Limit of detection 0.92 pg/ml Applications serum, plasma, cell culture supernatants Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN INTERLEUKIN-6 ELISA, HIGH SENSITIVITY

Cat. No. RGP013R RUO Other names IL-6, interferon-beta 2, B-cell stimulatory factor 2 Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 1.56 to 50 pg/ml Limit of detection < 0.8 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 100 µl/well

I Storage/Shipping 2-8 °C/ Wet ice

MONKEY INTERLEUKIN-6 ELISA

Cat. No. RBMS641/2R RUO Other names IL-6, interferon-beta 2, B-cell stimulatory factor 2 Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 1.9 to 120 U/ml Limit of detection 1.25 U/ml Applications baboon serum, cynomolgus serum Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

MOUSE INTERLEUKIN-6 ELISA

Cat. No. RBMS603/2R RUO Other names IL-6, interferon-beta 2, B-cell stimulatory factor 2 Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 31.3 to 2000 pg/ml Limit of detection 6.5 pg/ml Applications serum, plasma (EDTA, citrate), cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

136 For more information please go to www.biovendor.com IMMUNOASSAYS

RAT INTERLEUKIN-6 ELISA

Cat. No. RBMS625R RUO Other names IL-6, interferon-beta 2, B-cell stimulatory factor 2 Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 31.0 to 2000 pg/ml Limit of detection 12.0 pg/ml Applications serum, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN INTERLEUKIN-6 RECEPTOR BETA (CD130) ELISA

Cat. No. RGP008R RUO Other names gp130 Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 56.25 to 1800 pg/ml Limit of detection < 15 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 100 µl/well

Storage/Shipping 2-8 °C/ Wet ice IMMUNOASSAYS

HUMAN sINTERLEUKIN-6 RECEPTOR ELISA

Cat. No. RBMS214R RUO Other names IL-6R, CD126, Membrane glycoprotein 8 Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.08 to 5 ng/ml Limit of detection 0.01 ng/ml Applications serum, urine, amniotic fluid, plasma (EDTA, heparin), cell culture supernatant Sample requirements 20 µl/well (1:50 prediluted) Storage/Shipping 2–8 °C/Wet ice

HUMAN INTERLEUKIN-7 ELISA Interleukin-7 (IL-7) is a pleiotropic cytokine with a variety of activities. IL-7 supports differentiation of cytotoxic T-lymphocytes and promotes the generation of lymphokine-activated killer-cells. IL-7 is further responsible for the upregulation of the production of pro-inflammatory cytokines and the stimulation of the tumoricidal activity of monocytes/macrophages.

Cat. No. RGP014R RUO Other names IL-7, Lymphopoietin-1, pre-B-cell growth factor Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 6.25 to 200 pg/ml Limit of detection < 3 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 100 µl/well Storage/Shipping 2-8 °C/ Wet ice

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INTERLEUKIN-8 IL-8 (8 kDa, 72 amino acids) is a non-glycosylated protein and it is produced by the processing of a precursor protein of 99 amino acids. IL-8 is present in the synovial fluids of patients with rheumatoid arthritis and has been purified from plaque psoriasis scales. It is associated with sepsis, asthma and glomerulonephritis.

HUMAN INTERLEUKIN-8/NAP-1 ELISA

Cat. No. RBMS204/3R RUO Other names IL-8, Monocyte-derived neutrophil chemotactic factor, T-cell chemotactic factor, Neutrophil-activating protein 1, Granulocyte chemotactic protein 1, CXCL8 Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 15.6 to 1 000 pg/ml Limit of detection 2 pg/ml Applications serum, plasma (EDTA, heparin), cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

MONKEY INTERLEUKIN-8 ELISA

Cat. No. RBMS640/3R RUO Other names IL-8, Monocyte-derived neutrophil chemotactic factor, T-cell chemotactic factor, Neutrophil-activating protein 1, Granulocyte chemotactic protein 1, CXCL8 Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 19.5 to 1250 U/ml Limit of detection 2.5 U/ml Applications baboon serum, cynomolgus serum I Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN INTERLEUKIN-9 ELISA Interleukin-9 (IL-9) is a proinflammatory cytokine historically believed to be involved in type 2 immune responses. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin-9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness.

Cat. No. RBMS2081R RUO Other names IL-9, MEA, P40 cytokine, P40 T-cell and mast cell growth factor, T-cell/mast cell growth factor P40, TCGF III Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 3.1 to 200 pg/ml Limit of detection 0.5 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

138 For more information please go to www.biovendor.com IMMUNOASSAYS

INTERLEUKIN-10 IL-10 is an immunoregulatory protein produced by a number of cell lineages, including TH2 cells, B-cells and activated monocytes. IL-10 is an important factor in understanding autoimmunity and as a target molecule in the development of anti-rejection therapies.

HUMAN INTERLEUKIN-10 ELISA

Cat. No. RBMS215/2R RUO Other names IL-10, Cytokine synthesis inhibitory factor Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 3.2 to 200 pg/ml Limit of detection 0.99 pg/ml Applications serum, plasma (heparin, citrate), cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN INTERLEUKIN-10, HIGH SENSITIVITY

Cat. No. RGP015R RUO Other names IL-10, Cytokine synthesis inhibitory factor Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody

Calibration range 1.56 to 50 pg/ml IMMUNOASSAYS Limit of detection < 1.30 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 100 µl/well Storage/Shipping 2-8 °C/ Wet ice

MONKEY INTERLEUKIN-10 ELISA

Cat. No. RBMS642/2R RUO Other names IL-10, Cytokine synthesis inhibitory factor Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 3.9 to 250 U/ml Limit of detection 1.32 U/ml Applications baboon serum, cynomolgus serum Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

MOUSE INTERLEUKIN-10 ELISA

Cat. No. RBMS614/2R RUO Other names IL-10, Cytokine synthesis inhibitory factor Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 15.6 to 1000 pg/ml Limit of detection 5 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

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RAT INTERLEUKIN-10 ELISA

Cat. No. RBMS629R RUO Other names IL-10, Cytokine synthesis inhibitory factor Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 15.6 to 1000 pg/ml Limit of detection 1.5 pg/ml Applications serum, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

INTERLEUKIN-12 IL-12 (70 kDa) is an important pro-inflammatory cytokine produced by dentritic cells, macrophages and B lymphocytes and it has been shown to have multiple effects on T cells and natural killer cells. IL-12 displays significant anti-tumor activity. In vivo, IL-12 appears to play a major role in auto-immune disease, in the resistance to bacterial and parasitic infections, and in antiviral responses including HIV.

HUMAN INTERLEUKIN-12 (p70) ELISA

Cat. No. RBMS238R RUO Other names IL-12, Interleukin-12 subunit p35, p40, p70, Cytotoxic lymphocyte maturation factor, CLMF, NKSF, natural killer cell stimulatory factor Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 3.1 to 200 pg/ml Limit of detection 2.1 pg/ml Applications serum, plasma, cell culture supernatant

I Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN INTERLEUKIN-12 ELISA, HIGH SENSITIVITY

Cat. No. RGP016R RUO Other names IL-12, Interleukin-12 subunit p35, p40, p70, Cytotoxic lymphocyte maturation factor, CLMF, NKSF, natural killer cell stimulatory factor Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.78 to 25 pg/ml Limit of detection < 0.75 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 100 µl/well Storage/Shipping 2-8 °C/ Wet ice

MONKEY INTERLEUKIN-12 (p70) ELISA

Cat. No. RBMS646R RUO Other names IL-12, Interleukin-12 subunit p35, p40, p70, Cytotoxic lymphocyte maturation factor, CLMF, NKSF, natural killer cell stimulatory factor Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 3.9 to 250 U/ml Limit of detection 1.6 U/ml Applications cell culture supernatant, baboon serum Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

140 For more information please go to www.biovendor.com IMMUNOASSAYS

MOUSE INTERLEUKIN-12 (p70) ELISA

Cat. No. RBMS6004R RUO Other names IL-12, Interleukin-12 subunit p35, p40, p70, Cytotoxic lymphocyte maturation factor, CLMF, NKSF, natural killer cell stimulatory factor Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 15.6 to 1000 pg/ml Limit of detection 10.0 pg/ml Applications serum, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

MOUSE INTERLEUKIN-12 TOTAL (p40 + p70) ELISA

Cat. No. RBMS616R RUO Other names IL-12, Interleukin-12 subunit p35, p40, p70, Cytotoxic lymphocyte maturation factor, CLMF, NKSF, natural killer cell stimulatory factor Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 31.3 to 2000 pg/ml Limit of detection 1.9 pg/ml Applications serum, cell culture supernatant

Sample requirements 50 µl/well IMMUNOASSAYS Storage/Shipping 2–8 °C/Wet ice

HUMAN INTERLEUKIN-12/INTERLEUKIN-23 p40 ELISA IL-23 and IL-12 are heterodimeric cytokines which share the p40 subunit. Unlike IL-12, IL-23 has no effect on naive T cells but selectively activates memory T cells to secrete IFN-γ and IL-17. IL-23 is more potent than IL-12 in inducing long-lasting T-cell responses to viral antigens and can induce tumor-directed cytotoxic T-cell responses.

Cat. No. RBMS2013R RUO Other names IL-12 subunit p40, Cytotoxic lymphocyte maturation factor 40 kDa subunit, NK cell stimulatory factor chain 2, IL-12B, T-cell stimulating factor Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 31.3 to 2000 pg/ml Limit of detection < 10 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

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INTERLEUKIN-13 IL-13 (12 kDa, 132 amino acids) is a nonglycosylated immunoregulatory protein. IL-13 may play an important regulatory role in IgE-mediated atopic diseases. The measurement of IL-13 in body fluids may thus provide further information about the pathophysiology of atopic diseases.

HUMAN INTERLEUKIN-13 ELISA

Cat. No. RBMS231/3R RUO Other names IL-13, ALRH Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 1.6 – 100 pg/ml Limit of detection 0.73 pg/ml Applications amniotic fluid, cell culture supernatant, plasma, serum Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

MOUSE INTERLEUKIN-13 ELISA

Cat. No. RBMS6015R RUO Other names IL-13, ALRH Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 7.8 to 500 pg/ml Limit of detection 2.8 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice I

HUMAN INTERLEUKIN-13 RECEPTOR SUBUNIT ALPHA-2 ELISA

Cat. No. RGP027R RUO Other names IL-13Rα2, CD213A2, Cluster of differentiation 213A2 Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 156 to 5000 pg/ml Limit of detection < 150 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 100 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN INTERLEUKIN-15 ELISA Interleukin-15 (IL-15) is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2. IL-15 exerts its biological activites primarily on T cells. It is also essential in the development, survival and activation of NK cells.

Cat. No. RGP017R RUO Other names IL-15 Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 31.25 to 1000 pg/ml Limit of detection < 19 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 100 µl/well Storage/Shipping 2-8 °C/ Wet ice

142 For more information please go to www.biovendor.com IMMUNOASSAYS

MOUSE INTERLEUKIN-15/INTERLEUKIN-15 RECEPTOR ELISA

Cat. No. RBMS6023R RUO Other names IL15, IL-15/IL-15R Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 6.3 to 400 pg/ml Limit of detection 2.0 pg/ml Applications serum, plasma (EDTA), cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

INTERLEUKIN-17 Interleukin-17 is involved in the regulation of hematopoiesis and its effects are dependent on the physiological/pathological­ status of the organism. IL- 17 expression in airways is upregulated upon allergen exposure such as in allergic asthma. Its crucial role in T-cell activation suggests that IL-17 is involved in the development of autoimmune arthritis.

HUMAN INTERLEUKIN-17A ELISA

Cat. No. RBMS2017R RUO Other names IL-17, Interleukin-17A Product category Cytokines, chemokines and related molecules

Assay format Sandwich ELISA, Biotin-labelled antibody IMMUNOASSAYS Calibration range 1.6 to 100 pg/ml Limit of detection 0.5 pg/ml Applications serum, plasma (citrate, heparin), cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

MOUSE INTERLEUKIN-17 ELISA

Cat. No. RBMS6001R RUO Other names IL-17, Interleukin-17A Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 7.8 to 500 pg/ml Limit of detection 1.6 pg/ml Applications serum, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

RAT INTERLEUKIN-17 ELISA

Cat. No. RBMS635R RUO Other names IL-17A, CTLA8 Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 1.6 to 100 pg/ml Limit of detection 1.0 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

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HUMAN INTERLEUKIN-17AF ELISA

Cat. No. RBMS2082R RUO Other names IL-17F/IL17-A, IL-17 A/F, heterodimer, IL17AF Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 31.3 to 2 000 pg/ml Limit of detection 8.8 pg/ml Applications serum, plasma (citrate, heparin), cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN INTERLEUKIN-17F ELISA

Cat. No. RBMS2037R RUO Other names IL-17F Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 31.3 to 2000 pg/ml Limit of detection 15.5 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

MOUSE INTERLEUKIN-17F ELISA

Cat. No. RBMS6020R RUO I Other names Cytotoxic T lymphocyte associated serine esterase 8, CTLA 8, IL 17 Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 62.5 to 4 000 pg/ml Limit of detection 10 pg/ml Applications serum, plasma (EDTA), cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

PIG INTERLEUKIN-18 ELISA Interleukin-18 belongs to IL-1 family, it is a novel cytokine that plays an important role in the T-cell-helper type 1 (Th1) response, primarily by its ability to induce IFN gamma production in T cells and natural killer (NK) cells. IL-18 expression is detected in many different cells including macrophages, keratino- cytes, and osteoblasts.

Cat. No. RBMS672R RUO Other names IL-18, Interferon-gamma-inducing factor, Interleukin-1 gamma, IL-1 gamma Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 39 to 2500 pg/ml Limit of detection 23 pg/ml Applications serum, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

144 For more information please go to www.biovendor.com IMMUNOASSAYS

HUMAN INTERLEUKIN-21 ELISA Interleukin-21 is the most recently discovered member of the type-I cytokine family. IL-21 has pathologic function in immune-inflammatory diseases. It has antitumour activity and may have a role in the development of autoimmunity. IL-21 may have therapeutic potential as an antitumor agent.

Cat. No. RBMS2043R RUO Other names IL-21, Za11, Cytokine CX2 Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 78 to 5000 pg/ml Limit of detection 20.0 pg/ml Applications serum, plasma (EDTA, citrate), cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

INTERLEUKIN-22 Interleukin-22 is a new cytokine that regulates the production of acute phase proteins of the immunological response. It is produced by activated Th1 and NK cells acting primarily on epithelial cells and is involved in inflammatory responses. IL-22 plays a protective role in T cell-mediated hepatitis induced by Concanavalin A, acting as a survival factor for hepatocytes. IL-22 is present in high quantities in the blood of Crohn‘s disease patients in contrast to IFN- gamma and IL-17 levels.

HUMAN INTERLEUKIN-22 ELISA

Cat. No. RBMS2047R RUO IMMUNOASSAYS Other names IL-22, ILD110, ILTIF, Interleukin 10 related T cell derived inducible factor Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 31.3 to 2000 pg/ml Limit of detection 5.0 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 50 µl Storage/Shipping 2–8 °C

MOUSE INTERLEUKIN-22 ELISA

Cat. No. RBMS6016R RUO Other names IL-10-related T cell-derived inducible factor, TIF, zcyto18 Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 7.8 to 500 pg/ml Limit of detection 1.6 pg/ml Applications serum, plasma (citrate), cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

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INTERLEUKIN-23 IL-23 protein is a heterodimer, sharing a p40 subunit with IL-12, but having a distinct p19 subunit which is IL-23 specific. IL-23 plays a role in type 1-polarized T-cell immune responses. IL-23 has further been described as a key cytokine controlling inflammation in peripheral tissues. It was shown to be involved in inflammation of the nervous system and autoimmune diseases.

HUMAN INTERLEUKIN-23 ELISA

Cat. No. RBMS2023/3R RUO Other names IL-23 Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 15.6 to 2000 pg/ml Limit of detection 4.0 pg/ml Applications serum, plasma (EDTA, citrate), cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

MOUSE INTERLEUKIN-23 ELISA

Cat. No. RBMS6017R RUO Other names IL-23, IL-23P19, IL-23A, IL-23 p40, IL-23B Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 31.3 to 2 000 pg/ml Limit of detection 16.0 pg/ml Applications serum, plasma (citrate), cell culture supernatant Sample requirements 50 µl/well

I Storage/Shipping 2–8 °C/Wet ice

HUMAN INTERLEUKIN-27 ELISA Increased expression of IL-15 has been implicated with rheumatoid arthritis, inflammatory bowel disease and diseases affiliated with retroviruses HIV and HTLV-I.

Cat. No. RGP018R RUO Other names IL-27 Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 31.25 to 1000 pg/ml Limit of detection < 12.8 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 100 µl/well Storage/Shipping 2-8 °C/ Wet ice

146 For more information please go to www.biovendor.com IMMUNOASSAYS

HUMAN INTERLEUKIN-29 ELISA Interleukin-29 (IL-29) is a protein of the helical cytokine family and is a type III interferon sharing many functions with the type I family of interferons. IL-29 has significant antiviral activity and immunoregulatory properties and appears to inhibit T helper-2 (Th2) responses regarding inhibition of IL-13 produc- tion, compared with IL-4 or IL-5. The antiviral activities of IL-29 include the upregulation of MHC Class I expression on the cell surface and the expression of PKR.

Cat. No. RBMS2049R RUO Other names IL-29, IFN-lambda 1 Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 15.6 to 1 000 pg/ml Limit of detection 2 pg/ml Applications serum, plasma (EDTA), cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN INTERLEUKIN-31 ELISA Interleukin-31 (IL-31) is a cytokine with a four-helix bundle structure, which is preferentially produced by type 2 helper T cells (Th2). IL-31 is associated with the promotion of allergic and chronic inflammatory conditions such as dermatitis, pruritus, airway hypersensititvity and inflammatory bowel disease.

Cat. No. RBMS2041R RUO Other names IL-31 Product category Cytokines, chemokines and related molecules

Assay format Sandwich ELISA, Biotin-labelled antibody IMMUNOASSAYS Calibration range 7.8 to 500 pg/ml Limit of detection 1.0 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN INTERLEUKIN-33 ELISA Interleukin-33 (IL-33) is the most recently discovered member of the IL-1 family of cytokines, which includes IL-1α, IL-1β, IL-18 and IL-1Ra. In humans, IL-33 mRNA is predominantly found in dermal fibroblasts, bronchial and small airway epithelial cells and smooth muscle cells of skin and lung tissues. This cytokine is localized primarily in the nucleus where it is thought to play a role in transcriptional repression but can also be released from the cell.

Cat. No. RBMS2048R RUO Other names IL-33, IL1F11, DVS27-related protein Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 7.8 to 500 pg/ml Limit of detection 0.2 pg/ml Applications serum, plasma (citrate, heparin), cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

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IP-10 IP-10 is a member of the CXC subfamily of chemokines expressed by monocytes. It plays a pivotal role in immune system development and deployment. IP-10 is further involved in allergic contact dermatitis reactions and other allergic diseases. It appears during immune-mediated processes, in inflammation of the nervous system and in Alzheimer’s disease.

HUMAN IP-10 ELISA

Cat. No. RGP019R RUO Other names Interferon-gamma inducible protein 10kDa, CXCL10 Product category Cytokines and chemokines and related molecules, Immune Response, Infection and Inflammation Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 6.25 to 200 pg/ml Limit of detection < 5.7 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 100 µl/well Storage/Shipping 2-8 °C/ Wet ice

MOUSE IP-10 ELISA

Cat. No. RBMS6018R RUO Other names Interferon-gamma inducible protein -10kD, Small inducible cytokine B10, CXCL10 Product category Cytokines, chemokines and related molecules, Immune response, infection and inflammation, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 7.8 to 500 pg/ml Limit of detection 6.5 pg/ml Applications serum, plasma (EDTA, citrate), cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice I–K

IRISIN ELISA Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. Circulating irisin levels were shown to be upregulated after acute exercise. Increase of irisin under conditions of obesity may indicate a physiological function to improve glucose tolerance.

Cat. No. RAG018R RUO Other names Fibronectin Type III Domain-containing Protein 5, Fibronectin Type III Repeat-containing Protein 2, FNDC5 Product category Energy metabolism and body weight regulation, Animal studies Assay format Competitive ELISA, Immobilized antigen Calibration range 0.001 to 5 μg/ml Limit of Detection 1 ng/ml Applications Cell culture supernatant, Plasma, Serum Sample requirements Storage/Shipping 2-8 °C/ Wet ice

148 For more information please go to www.biovendor.com IMMUNOASSAYS

KIM-1 KIM-1 is a type I trans-membrane structural glycoprotein located in the renal proximal tubule epithelial cells. These cells undergo regeneration after various forms of injury and shed KIM-1 antigen into the urine. Thus urinary KIM-1 is an early and specific biomarker for tubular kidney injury. KIM-1 has become widely recognized by many organizations and agencies, including FDA, as an excellent tool in pre-clinical studies to monitor acute kidney tubular toxicity, by identifying adverse reactive drugs and therapeutic agents in drug development. Kidney injury caused by therapeutic agents and drug induction is a common type of injury requiring appropriate monitoring and intervention. Current standards using blood urea nitrogen and creatinine are considered late indicators of kidney injury and are often non-specific. KIM-1 has been shown time and again to outperform traditional biomarkers of kidney injury in preclinical biomarker studies.The detection of KIM-1 can occur in as little as six hours post injection of an agent known to cause kidney injury.

HUMAN KIM-1 ELISA

Cat. No. RHBA001R RUO Product category Renal disease Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0 to 10 ng/ml Applications Urine Sample requirements 50 μl/well Storage/Shipping 2-8 °C/ Wet ice

RAT KIM-1 ELISA

Cat. No. RRBA001R RUO Product category Renal disease

Assay format Sandwich ELISA, HRP-labelled antibody IMMUNOASSAYS Calibration range 0 to 10 ng/ml Applications Urine Sample requirements 50 μl/well Storage/Shipping 2-8 °C/ Wet ice

HUMAN KL-6 ELISA KL-6 is a high molecular weight human glycoprotein secreted by type II alveolar cells in the lung, and its serum levels increase in patients with pneumonia of various causes, as well as ocular sarcoidosis.

Cat. No. RSCYK243882R RUO Other names Sialylated carbohydrate antigen, Krebs von den Lungen-6 Product category Immune response, infection and inflammation Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 201 to 4 020 U/mL Limit of Detection 1 U/ml (with 2SD method) Applications serum Sample requirements 10 μl/well Storage/Shipping 2-8 °C/ Wet ice

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HUMAN LECITHIN-CHOLESTEROL ACYLTRANSFERASE ELISA Human Lecithin: cholesterol acyltransferase (LCAT) is a glycoprotein with a molecular mass of approximately 58 kDa. It is the key enzyme responsible for esterification of free cholesterol to cholesteryl esters in circulating plasma lipoproteins, primarily in high density lipoprotein (HDL). The tertiary structure of LCAT is maintained by two disulfide bridges, similar to lipases and other proteins of the α/β hydrolase fold family. Mature LCAT protein is synthesized from a 440 residue precursor by following cleavage of a 24 residue signal peptide. The mature protein contains 416 amino acids and is heavily N-glycosylated. LCAT is abundant in blood plasma and it is present in other organs, including liver, brain and testes. In plasma LCAT is associated with ApoD which frequently co-purify. A recent study suggests that LCAT can act as an antioxidant and prevent the accumulation of oxidized lipid in plasma lipoproteins. LCAT performs a central role in HDL metabolism by catalyzing the formation of cholesteryl esters on HDL through the transfer of fatty acids from the sn-2 positions of phosphatidylcholine (PC) to cholesterol. The role of LCAT in atherosclerosis is unclear. Dullaart et al. showed that plasma LCAT activity is elevated in metabolic syndrome and may be a marker of subclinical atherosclerosis. Sethi et al. demonstrated that low lecithin-cholesterol acyltransferase (LCAT) activities and high pre-ß1-HDL concen- trations are strong positive risk markers for ischemic heart disease and are independent of HDLcholesterol. Miida et al. demonstrated that plasma pre β1-HDL concentration increase in subjects with low LCAT activity. They also reported that patients with coronary artery diseae (CAD) had higher pre-ß1-HDL concentra- tions than did normolipidemic subjects. Holleboom et al. showed that low plasma LCAT levels (reflecting low LCAT activity) are not associated with an increased risk of future (CAD) in the general population. However, other studies showed a positive association of LCAT levels with carotid atherosclerosis in patients with the metabolic syndrome as well as in control subjects whereas, LCAT activity was reduced in patients with CAD and in patients with acute myocardial infarction. In summary, LCAT activity might be reduced in the acute phase of a myocardial infarction. Mutations of LCAT on chromozome 16 resulting in homozygous or compound heterozygous form can cause two major phenotypes: FLD (familial LCAT deficiency) and FED ( Fish Eye Disease). Patients with FLD have a complete loss of both α-LCAT activity and β-LCAT activity and an increased proportion of unesterified cholesterol in plasma. In FED is partial loss of α-LCAT activity with normal elevated free cholesterol in plasma. Both FLD and FED are characterized by the development of corneal opacities.

Cat. No. RD191122200R RUO Other names LCAT, Phosphatidylcholine-sterol acyltransferase, Phospholipid-cholesterol acyltransferase Product category Cardiovascular disease, Lipoprotein metabolism Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 2.5 to 160 ng/ml Limit of Detection 0.27 ng/ml Applications serum, plasma (EDTA, citrate), cerebrospinal fluid Sample requirements serum and plasma: 5µl/well CSF: 10µl/well Storage/Shipping 2-8 °C/ Wet ice

L LEPTIN Leptin (16 kDa, 146 amino acid residues), the product of the ob gene, is produced in the adipose tissue and is considered to play an important role in ap- petite control, fat metabolism and body weight regulation. It targets the hypothalamus, affecting food intake. It decreases the appetite and increases energy consumption. Leptin is secreted in circadian fashion with nocturnal rise in both lean and obese patients. Leptin may be linked to reproductive function.

HUMAN LEPTIN ELISA

Cat. No. RD191001100 IVD CE Other names LEP, OB, Obese protein Product category Energy metabolism and body weight regulation, Reproduction Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 1 to 50 ng/ml Limit of detection 0.2 ng/ml Applications serum, plasma Sample requirements 35 µl/well Storage/Shipping 2–8 °C/Wet ice

MOUSE/RAT LEPTIN ELISA

Cat. No. RD291001200R RUO Other names LEP, OB, Obese protein Product category Energy metabolism and body weight regulation, Reproduction, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 100 to 4000 pg/ml Limit of detection 30 pg/ml (mouse), 50 pg/ml (rat) Applications serum, plasma, cell culture medium Sample requirements 5 µl/well Storage/Shipping 2–8 °C/Wet ice

150 For more information please go to www.biovendor.com IMMUNOASSAYS

HUMAN LEPTIN RECEPTOR ELISA OB-R is a leptin binding protein, a member of the class I cytokine receptor family. It exists in multiple forms with a common extracellular domain and a variable lenght cytoplasmatic portion. OB-R is important in body weight regulation. OB-R may act as a negative regulator of leptin activity and it may main- tain a pool of available bioactive leptin by binding and delaying its clearance from circulation.

Cat. No. RD194002100 RUO Other names LEPR, OB-R, CD295 Product category Energy metabolism and body weight regulation, Reproduction Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 2 to 100 ng/ml Limit of detection 0.04 ng/ml Applications plasma (EDTA, heparin) Sample requirements 35 µl/well Storage/Shipping 2–8 °C/Wet ice

LUTEINIZING HORMONE (LH) Luteinizing hormone (LH) is produced in both men and women from the anterior pituitary gland in response to luteinizing hormone-releasing hormone (LH-RH or Gn-RH), which is released by the hypothalamus. LH, also called interstitial cell-stimulating hormone (ICSH) in men, is a glycoprotein with a molecular weight of approximately 30.000 daltons. It is composed of two non covalently associated dissimilar amino acid chains, alpha and beta. The alpha chain is similar to that found in human thyroid-stimulating hormone (TSH), follicle stimulating hormone (FSH), and human chorionic gonadotropin (hCG). The difference between these hormones lie in the amino acid composition of their beta subunits, which account for their immunological differentia- tion. The basal secretion of LH in men is episodic and has the primary function of stimulating the interstitial cells (Leydig cells) to produce testosterone. The variation in LH concentrations in women is subject to the complex ovulatory cycle of healthy menstruating women, and depends upon a sequence of hormonal events along the gonado-hypothalamic-pituitary axis. The decrease in progesterone and estradiol levels from the preceeding ovulation initiates each menstrual cycle. As a result of the decrease in hormone levels, the hypothalamus increases the secretion of gonadotropin-releasing factors (GnRF), IMMUNOASSAYS which in turn stimulates the pituitary to increase FSH production and secretion. The rising FSH levels stimulate several follicles during the follicular phase, one of these will mature to contain the egg. As the follicle develops, estradiol is secreted, slowly at first, but by day 12 or 13 of a normal cycle increasing rapidly. LH is released as a result of this rapid estradiol rise because of direct stimulation of the pituitary and increasing GnRF and FSH levels. These events constitute the preovulatory phase. Ovulation occurs approximately 12 to 18 hours after the LH reaches a maximum level. After the egg is released, corpus luteum is formed which secretes progesterone and estrogen – two feedback regulators of LH. The luteal phase rapidly follows this ovulatory phase, and is characterized by high progesterone levels, a second estradiol increase, and low LH and FSH levels. Low LH and FSH levels are the result of the negative feedback effects of estradiol and progesterone on the hypotalamic-pituitary axis. After conception, the developing embryo produces hCG, which causes the corpus luteum to continue producing progesterone and estradiol. The corpus luteum regresses if pregnancy does not occur, and the corresponding drop in progesterone and estradiol levels results in menstruation. The hypothalamus initiates the menstrual cycle again as a result of these low hormone levels. Patients suffering from hypogonadism show increased concentrations of serum LH. A decrease in steroid hormone production in females is a result of immature ovaries, primary ovarian failure, polycystic ovary disease, or menopause; in these cases, LH secretion is not regulated. A similar loss of regulatory hormones occurs in males when the testes develop abnormally or anorchia exists. High concentrations of LH may also be found in primary testicular failure and Klinefelter syndrome, although LH levels will not necessarily be elevated if the secretion of androgens continues. Increased concentrations of LH are also present during renal failure, cirrhosis, hyperthyroidism, and severe starvation. A lack of secretion by the anterior pituitary may cause lower LH levels. As may be expected, low levels may result in infertility in both males and females. Low levels of LH may also be due to the decreased secretion of GnRH by the hypothalamus, although the same effect may be seen by a failure of the anterior pituitary to respond to GnRH stimulation. Low LH values may therefore indicate some dysfunction of the pituitary or hypothalamus, but the actual source of the problem must be confirmed by other tests. In the differential diag- nosis of hypothalamic, pituitary, or gonadal dysfunction, assays of LH concentration are routinely performed in conjunction with FSH assays since their roles are closely interrelated. Furthermore, the hormone levels are used to determine menopause, pinpoint ovulation, and monitor endocrine therapy.

HUMAN LH ELISA

Cat. No. RCAN-LH-4040R RUO Other names Luteinizing hormone, Lutropin Product category Reproduction Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 1 to 100 IU/l Limit of detection 0.2 IU/l Applications serum Sample requirements 25 µl/well Storage/Shipping 2–8 °C/Wet ice

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RAT LH ELISA (S-TYPE) ELISA, HIGH SENSITIVITY

Cat. No. RSHAKRLH-010SR RUO Other names Luteinizing hormone, Lutropin Product category Animal studies, Reproduction Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.313 to 10 ng/ml Limit of detection 31.3 pg/ml Applications serum, plasma Sample requirements 10 µl Storage/Shipping 2–8 °C/Wet ice

HUMAN LIF ELISA LIF is a cytokine which was primarily described as a product of activated T lymphocytes and macrophages. It plays a major role in human inflammatory lung diseases and it is involved in acute and chronic inflammations including pneumonia, Rheumatoid arthritis, carcinoma (adenocarcinoma, mesothe- lioma, melanoma) and peritonitis.

Cat. No. RBMS242R RUO Other names Leukemia inhibitory factor Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 3.15 to 200 pg/ml Limit of detection 0.66 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

L–M HUMAN LIPOCALIN-2/NGAL ELISA Lipocalin 2 a member of lipocalin protein family is expressed mainly by epithelial tissues and neutrophils. Previous studies have focused on the role of this protein in innate immune response to bacterial infection and in apoptosis. Several recent reports suggest that Lippocalin 2 might represent a sensitive biomarker for early renal injury and for obesity and its associated pathologies.

Cat. No. RD191102200R RUO Other names NGAL Product category Energy metabolism and body weight regulation, Renal disease Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.3 to 10 ng/ml Limit of detection 0.02 ng/ml Applications serum, plasma, urine Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

152 For more information please go to www.biovendor.com IMMUNOASSAYS

HUMAN MATRIX METALLOPROTINASE-3 ELISA Matrix metalloproteinase-3 (MMP-3) also called stromelysin or transin, is a proteoglycanase closely related to collagenase (MMP1) with a wide range of substrate specificities. The complete primary structure for human MMP-3, which has 477 residues including a 17-residue signal peptide. MMP-3 and collagenase are 54% identical in sequence, suggesting a common origin for the evolution of the two proteinases. MMP-3 and collagenase expression are coordinately modulated in synovial fibroblast cultures.1 MMP-3 is a secreted metalloprotease produced predominantly by connective tissue cells. Together with other metalloproteases, it can synergistically degrade the major components of the extracellular matrix. It is capable of degrading proteoglycan, fibronectin, laminin, and type IV collagen, but not interstitial type I collagen. MMP-3 genotype may be an important determinant of vascular remodeling and age-related arterial stiffening, with the heterozygote having the optimal balance between matrix accumulation and deposition.2 The standard product used in this kit is recombinant human MMP-3, consisting of 460 amino acids with the molecular mass of 52KDa. The detected MMP-3 includes zymogen and active enzyme.

Cat. No. RIM001R RUO Other names MMP-3 Product category Others Assay format Sandwich ELISA, Biotin-labelled antibody Limit of detection 4 pg/ml Applications serum, plasma Storage/Shipping 2-8 °C/ Wet ice

HUMAN MATRIX METALLOPROTEINASE-9 ELISA Matrix metalloproteinase-9 (MMP-9) is synthesized and secreted in monomeric form as zymogen. MMP-9 in coordination with other MMPs, play a role in normal tissue remodeling events such as neurite gowth, embryonic development, angiogenesis, ovulation, mammary gland involution and wound healing. MMP-9 with other MMPs is also involved in osteoblastic bone formation and/or inhibits osteoclastic bone resorption. Elevated expression of MMP-9, along with MMP-2 is usually seen in invasive and highly tumorigenic cancers. IMMUNOASSAYS Cat. No. RBMS2016/2R RUO Other names MMP-9 Product category Others Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.23 to 15 ng/ml Limit of detection 0.05 ng/ml Applications serum, plasma (heparin, citrate), cell culture supernatant Sample requirements 10 µl /well (1:25 prediluted) Storage/Shipping 2-8 °C/ Wet ice

HUMAN MATRIX METALLOPROTEINASE-13 ELISA Matrix metalloproteinase-13 (MMP-13) plays potential role in tumor metastasis and invasion. MMP-13 has originally been identified in breast carcinomas. MMP-13 and the expression of the enzyme is upregulated under conditions that promote endothelial cell growth and vascular differentiation. The over- expression of MMP-13 associated with nonhealing wounds is shown for chronic dermal ulcers. There is growing body of evidence that MMP-13 is a major player in the disease condition of rheumatoid arthritis and osteoarthritis.

Cat. No. RBMS2022R RUO Other names MMP-13 Product category Others Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.31 to 20 ng/ml Limit of detection 0.18 ng/ml Applications serum, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2-8 °C/ Wet ice

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HUMAN MICA ELISA The human MHC class I chain-related genes (MICA and MICB) are located within the HLA class I region of chromosome 6. MICA/MICB expression is elevated in the sera of patients with colorectal carcinoma and widely expressed in prostate carcinoma. MICA/MICB may be a novel biomarker for prostate cancer and its expression is also monitor in Crohn’s disease.

Cat. No. RGP026R RUO Product category Cytkines, chemokines and related molecules, Reproduction Assay format Sanwich ELISA, Biotin-labelled antibody Calibration range 156 to 5000 pg/ml Limit of detection 123 pg/ml Applications buffer solution, cell culture supernatant Sample requirements 100 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN MIDKINE ELISA Midkine (13 kDa), a product of a retinoic acid responsive gene, belongs to the family of heparin binding growth/differentiation factors. It is most strongly expressed in midgestation. In the adult MK expression is restricted. MK is involved in the pathogenesis of inflammatory diseases and human carcinomas. MK can be applied to the diagnosis of malignancy. It is expressed during the reparative stage of bone fractures, also suppresses infection of cells by some viruses including HIV. Anti-apoptotic and cell protecting activity of MK makes it a promissing in therapy.

Cat. No. RD191042200R RUO Other names MK, NEGF-2, Neurite growth promoting factor 2 Product category Oncology, Immune response, infection and inflammation Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.2 to 10 ng/ml Limit of detection 0.033 ng/ml Applications serum, plasma (citrate, heparin) Sample requirements 20 µl/well Storage/Shipping 2–8 °C/Wet ice M–N

MONOCYTE CHEMOTACTIC PROTEIN-1 Monocyte chemotactic protein-1 (MCP-1) is a member of the C-C family of chemokines. Chemokines are mediators that share the capacity to induce di- rectional migration of leukocytes. MCP-1 is a chemoattractant for many cell types such as monocytes, neutrophils, hepatic stellate cells, granulocytes and T lymphocytes. MCP-1 is believed to play a role in a variety of pathological conditions, including inflammatory and immune reactions, atherosclerosis and neoplasia. Monocyte Chemotactic Protein-1 (MCP-1) is also known as Monocyte Chemotactic Activating Factor (MCAF) or CCL2.

HUMAN MONOCYTE CHEMOTACTIC PROTEIN-1 ELISA

Cat. No. RBMS281R RUO Other names MCP-1, CCL2, C-C motif chemokine 2, MCAF Product category Cytokines and chemokines and related molecules, Energy metabolism and body weight regulation Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 15.6 to 1000 pg/ml Limit of detection 2.3 pg/ml Applications serum, plasma (EDTA, heparin), cell culture supernatant Sample requirements 20 µl Storage/Shipping 2–8 °C/Wet ice

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MOUSE MONOCYTE CHEMOTACTIC PROTEIN-1 ELISA

Cat. No. RBMS6005R RUO Other names MCP-1, CCL2, Monocyte secretory protein JE Product category Energy metabolism and body weight regulation, Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 15.6 to 1 000 pg/ml Limit of detection 2.2 pg/ml Applications serum, cell culture supernatant Sample requirements 50 μl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN MPO ELISA Myeloperoxidase (MPO) is a glycoprotein with a alpha2beta2 heteromultimer expressed in all cells of the myeloid linage. MPO is abundantly present in azurophilic granules of polymorphonuclear neutrophils. It is an important enzyme used during phagocytic lysis of engulfed foreign particles which takes part in the defense of the organism through production of hypochlorus acid. Involvement of MPO has been described in diseases such as atherosclerosis, lung, cancer, Alzheimer‘s disease and multiple sclerosis. Autoimmune antibodies to MPO are involved in Wegener‘s disease.

Cat. No. RHK324R RUO Other names Myeloperoxidase Product category Cardiovascular disease, Immune Response, Infection and Inflammation Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.4 to 100 ng/ml Limit of detection 0.4 ng/ml IMMUNOASSAYS Applications plasma, cell culture medium, sputum Sample requirements 100 μl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN MxA PROTEIN ELISA MxA is a protein induced in peripheral lymphoid cells by type 1 interferons during active viral infections. This protein plays an important role in antiviral activity in cells against a wide variety of viruses, including influenza, parainfluenza, measles, coxsackie, hepatitis B virus, and Thogoto virus. Several clinical studies have reported on the possible use of MxA protein expression in peripheral blood mononuclear cells as a marker distinguishing viral from bacterial disease, and reliable marker for type I IFN bioavaibility during IFN treatment of chronic viral hepatitis and multiple sclerosis.

Cat. No. RD194349200R RUO Other names Myxovirus resistance protein 1 Product category Immune Response, Infection and Inflammation, Sepsis Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.375 to 12 ng/ml Limit of detection 0.03 ng/ml Applications whole blood Storage/Shipping 2-8 °C/ Wet ice

HUMAN NESFATIN-1 ELISA Nesfatin-1 is a satiety molecule found in hypothalamic nuclei which regulate appetite. Nesfatin-1 decreases body weight after chronic intra-cerebroven- tricular administration.

Cat. No. RD191227200R RUO Other names Nucleobindin-2, DNA-binding protein NEFA, Gastric cancer antigen Zg4, NUCB2, NEFA Product category Energy metabolism and body weight regulation, Neural tissue markers Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.125 to 4 ng/ml Limit of detection 0.021 ng/ml Applications serum, plasma Sample requirements 20 µl/well Storage/Shipping 2–8 °C/Wet ice [email protected] 155 IMMUNOASSAYS

HUMAN/RAT NO SYNTHASE I ELISA NO Synthase is an enzyme in the body that contributes to transmission from one neuron to another, to the immune system and to dilating blood vessels. It does so by synthesis of nitric oxide from the terminal nitrogen atom of L-arginine in the presence of NADPH and dioxygen. NOS is the only known enzyme that binds flavin adenine dinucleotide, flavin mononucleotide, heme, tetrahydrobiopterin and calmodulin.

Cat. No. RSCYK100R RUO Other names Nitric Oxide Synthase, NOS Product category Blood pressure regulation and NO metabolism, Animal studies Assay format Competitive ELISA, Immobilized antibody Calibration range 0.412 to 100 ng/ml Applications tissue extract Sample requirements 50 μl/well Storage/Shipping 2–8 °C/Wet ice

OBESTATIN Obestatin is a 23 amino acid residues peptide isolated from the rat stomach. The peptide shares the precursor with a food intake stimulating peptide, ghrelin, but possesses reducing effects on food intake, gut motility and body weight.

HUMAN OBESTATIN ELISA

Cat. No. RSCYK231R RUO Proghrelin, Appetite-regulating hormone, Growth hormone secretagogue, Growth hormone-releasing peptide, Motilin-related Other names peptide, Protein M46 Product category Energy metabolism and body weight regulation Assay format Competitive ELISA, Immobilized antibody Calibration range 0.412 to 100 ng/ml Applications serum, plasma Sample requirements 20 μl/well N–O Storage/Shipping 2–8 °C

MOUSE/RAT OBESTATIN ELISA

Cat. No. RSCYK230R RUO Proghrelin, Appetite-regulating hormone, Growth hormone secretagogue, Growth hormone-releasing peptide, Motilin-related Other names peptide, Protein M46peptide, Protein M46 Product category Animal studies, Energy metabolism and body weight regulation Assay format Competitive ELISA, Immobilized antibody Calibration range 0.082 to 20 ng/ml Applications serum Sample requirements 25 μl Storage/Shipping 2–8 °C

156 For more information please go to www.biovendor.com IMMUNOASSAYS

HUMAN OMENTIN-1 ELISA Omentin is a newly identified secretory protein, highly and selectively expressed in visceral adipose tissue. The mature omentin is a secretory glycoprotein consisting of 295 amino acids and its basic structural unit is a 120-kDa homotrimer in which 40-kDa polypeptides are bridged by disulfide bonds. Omentin has been identified in other tissue at lower expression levels such are Paneth cells, endothelial cells, and visceral adipose stromal-vascular cells. A homolog of omentin-1 sharing 83% amino acid identity was referred to as omentin-2. Omentin-1 was shown to be the major circulating isoform in human plasma. Lean subjects had significantly higher omentin-1 plasma levels than obese and overweight subjects. Plasma omentin-1 levels were inversely correlated with BMI, waist circumference, leptin levels, and insulin resistance as measured by homeostasis model assessment and positively correlated with adiponectin and HDL levels. In summary, decreased omentin-1 levels are associated with increasing obesity and insulin resistance.

Cat. No. RD191100200R RUO Other names Intelectin-1, Intestinal lactoferin receptor, Endothelian lectin HL-1, Galactofuranose-binding lectin Product category Diabetology, Energy metabolism and body weight regulation, Reproduction Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 2 to 64 ng/ml Limit of detection 0.5 ng/ml Applications serum, plasma Sample requirements 6 μl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN OSTEOACTIVIN ELISA Osteoactivin (OA) is a transmembrane glycoprotein of 572 amino acid residues. OA may exist as a 65-kD unglycosylated cellular protein or as multiple glycosylated proteins with molecular size varying between 80-kD to 139-kD. The transmembrane OA can be proteolytically cleaved, which results in the release of the extracellular domains acting as cytokines or growth factors. OA expression is associated with cell differentiation with high expression levels of OA protein found in the nervous system, basal layer of the skin, germinal cells of hair follicles, and in developing nephrons of the kidney in mouse embryos.

In immune cells, OA was detected in differentiated macrophages, lymphocytes, and dendritic cells. OA has a regulatory role in osteoblast differentiation IMMUNOASSAYS and bone formation. OA is a key mediator of BMP-2-induced osteoblast differentiation. OA is implicated in physiological and pathophysiological cascades of tissue injury and repair. Aberrant OA expression is linked to glaucoma, kidney disease, osteoarthritis, amyotrophic lateral sclerosis and several types of cancer. The discovery that osteoactivin is selectively overexpressed in aggressive bone metastatic breast cancer cells suggests an important role for this molecule in the progression to metastatic breast cancer.

Cat. No. RD191170200R RUO Other names OA, Dchil, Gpnmb, Hgfin Product category Bone and cartilage metabolism, Neural tissue markers, Oncology, Renal disease Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.78 to 50 ng/ml Limit of detection 0.102 ng/ml Applications serum, plasma Sample requirements 15 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN OSTEOCALCIN ELISA Osteocalcin or bone Gla protein (B.G.P) is the major non-collagen protein of the bone matrix. It has a molecular weight of 5800 Da and contains 49 amino-acids, including 3 residues of gamma carboxyl glutamic acid. Osteocalcin is synthesized in the bone by the osteoblasts. After production, it is partly incorporated in the bone matrix and the rest is found in the blood circulation. The exact physiological function of osteocalcin is still unclear. A large number of studies show that the circulating levels of osteocalcin reflect the rate of bone formation. The determination of the blood levels of osteocalcin is valuable for the identification of women at risk of developing osteoporosis, monitoring bone metabolism during the perimenopause and postmenopause and monitoring bone metabolism during hormone replacement therapy and treatment of premenopausal, women with LH-RH agonists monitoring bone metabolism in patients with growth hormone deficiency, hypothyroidism, hyperthyroidism, chronic renal failure.

Cat. No. RIS002R RUO Other names OST Product category Bone and cartilage metabolism Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 2 to 50 ng/ml Limit of detection 0.4 ng/ml Applications serum, plasma Sample requirements 25 µl/well Storage/Shipping 2–8 °C/Wet ice

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HUMAN OSTEOPROTEGERIN ELISA OPG (401 amino acid residues, 60kDa as a monomer, 120 kDa as a disulfide-linked dimer) belongs to TNF receptor superfamily. It is produced in various tissues, e.g. bone, skin, liver, stomach, intestine and lung. OPG inhibits the binding of RANK to RANKL and thus inhibits the recruitment, proliferation and activation of osteoclasts. It acts as a soluble factor in the regulation of bone mass. Osteoclast formation activity may be monitored by determination of concentration ratio of RANKL/OPG. Alteration of this ratio may be the cause of bone loss in imbalances in bone metabolism – osteoporosis, osteopetrosis, metastatic osteolytic lesions, hypercalcemia and rheumatic bone degradation.

Cat. No. RD194003200 IVD CE Other names OPG, OCIF, Osteoclastogenesis inhibitory factor Product category Bone and cartilage metabolism Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 1.5 to 60 pmol/l Limit of detection 0.03 pmol/l Applications serum, plasma Sample requirements 35 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN p53 ELISA p53 is the most commonly mutated gene in human cancer. It is highly conserved and expressed in most normal tissues. p53 is considered a stress response gene, and acts to induce cell cycle arrest or apoptosis in response to DNA damage, thereby maintaining genetic stability in the organism. It is a tumor suppressor gene which induces apoptosis.

Cat. No. RBMS256R RUO Other names Tumor suppressor p53, TP53, Li-Fraumeni syndrome Product category Oncology Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.78 to 50 U/ml Limit of detection 0.33 U/ml

O–P Applications serum, cell culture supernatant Sample requirements 50 µl Storage/Shipping 2–8 °C/Wet ice

HUMAN PAI-1 ELISA PAI-1 is the primary inhibitor of plasminogen activators in plasma. PAI-1 is a single-chain glycoprotein with a molecular weight of 47 kDa. It is synthesized in the liver and by endothelial cells, and its synthesis is regulated by several physiologic mediators including endotoxin, interleukin-1, fibroblast growth factor-2, and lipids. PAI-1 is an important inhibitor of the fibrinolytic system, therefore, elevated levels could suppress fibrinolysis and result in an increased risk of thrombosis.

Cat. No. RBMS2033R RUO Other names Endothelial plasminogen activator inhibitor Product category Others Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 78 to 5000 pg/ml Limit of detection 29 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 50 µl/well (1:50 prediluted) Storage/Shipping 2–8 °C/Wet ice

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HUMAN PANCTREATIC-DERIVED FACTOR ELISA Pancreatic-derived factor (PANDER, FAM3B) is a PANDER is a 235-amino acid member of the FAM3 family of cytokine molecules that is highly expressed in pancreatic islets. It is secreted from both pancreatic α and β-cells, and appears to colocalize with both insulin and glucagon. In vitro, PANDER pretreat- ment or viral-mediated overexpression promotes apoptosis of islet β cells and inhibits insulin secretion. Under conditions of insulin resistance, chronic hyperglycemia potently activates PANDER expression and stimulates the cosecretion of insulin and PANDER in β cells. PANDER binds to the liver cell membrane and induces insulin resistance, resulting in increased gluconeogenesis. PANDER was found to be expressed in rodent and human liver, and its expression is increased in the liver of diabetic mice and rats. Hepatic overexpression of PANDER promotes lipogenesis in the liver and induces insulin resistance in C57BL/6 mice, whereas the inactivation of hepatic PANDER markedly reduces steatosis, insulin resistance, and hyperglycemia in db/db mice. PANDER deficiency protects mice from high-fat-diet-induced hyperglycemia by decreasing gluconeogenesis in the liver. In summary, PANDER plays an important role in the progression of type 2 diabetes by negatively regulating islet β-cell function and insulin sensitivity in the liver. PANDER knock out mice on high-fat diet are glucose intolerant yet resistant to fasting hyperglycemia and hyperinsulinemia. RNA-mediated knockdown of hepatic PANDER significantly attenuated steatosis. Hepatic PANDER silencing also attenuated insulin resistance and hyperglycemia in db/db mice. In cultured hepatocytes, PANDER overexpression induced lipid deposition, increased Forkhead box protein O1 (FOXO1) expression, and suppressed insulin-stimulated Akt activation and FOXO1 inactivation. Moreover, FOXO1 overexpression increased PANDER expression in cultured hepatocytes and mouse livers IFN-γ has been shown to regulate PANDER expression in mouse islets in a dose- and time-dependent manner, suggesting that PANDER may be involved in IFN-γ-mediated apoptosis of islet β cells Monocyte chemotactic protein-1 induced PANDER mRNA transcription and protein synthesis in MIN6 cells and islets.

Cat. No. RD191259200R RUO Other names PANDER, FAM3B Product category Energy metabolism and body weight regulation Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.0625 to 4 ng/ml Limit of detection 0.037 ng/ml Applications plasma, serum Sample requirements Storage/Shipping 2–8 °C/Wet ice IMMUNOASSAYS

HUMAN PARATHYROID HORMONE ELISA Human parathyroid hormone (hPTH) is a major physiological regulator of phosphocalcic metabolism. hPTH increases serum calcium concentrations by its actions on kidney (enhancing tubular Ca++ reabsorption and phosphate excretion) and bone (stimulating osteoclastic activity and bone resorption). It indirectly affects intestinal absorption of Ca++ by stimulating renal 1α-hydroxylation of 25 hydroxyvitamin D. The release of PTH is controlled in a negative feedback loop by the serum concentration of Ca++. PTH is synthesized in the chief cells of the parathyroid glands and secreted as an 84 amino acid mol- ecule called “intact PTH”, which is the main bioactive product. This molecule is degraded by proteolytic cleavage between amino acids 33–37 at peripheral sites to form biologically active aminoterminal fragments and biologically inactive carboxyl-terminal fragments. The carboxyl-terminal fragments are cleared only by glomerular filtration, while the bioactive intact PTH and amino-terminal fragments are also metabolically degraded in the liver and other tissues. The half-life of the carboxylterminal fragments increases dramatically in patients with renal failure. Thus, the measurement of intact PTH correlates best with the hormone production and biological activity. The measurement of intact hPTH is used to establish the diagnosis of primary hyperparathyroidism by demonstrating elevated serum levels of bioactive PTH. It allows documenting the occurrence of secondary hyperparathyroidism in patients with Vit.D defi- ciency, intestinal malabsorption, or renal failure. In this last situation, the absence of interference with the inactive carboxyl-terminal fragments is especially valuable. The specificity and high sensitivity of the assay also allows differentiating clearly low serum PTH levels in hypoparathyroidism or in tumor-induced hypercalcaemia.

Cat. No. RIS003R RUO Other names PTH Product category Bone and cartilage metabolism Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 15 to 1040 pg/ml Limit of detection 2 pg/ml Applications serum, plasma Sample requirements 200 µl/well Storage/Shipping 2–8 °C/Wet ice

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PECAM-1 PECAM-1 is a newly characterized adhesion molecule that belongs to the immunoglobulin superfamily. It is a transmembrane glycoprotein with a molecular weight of approximately 130 kDa, depending on the degree of glycosylation. PECAM-1 is constitutively expressed on all vascular cells and has provided a useful immunohistochemical marker of blood vessels, particularly in the setting of angiogenesis. PECAM-1 is a sensitive and specific marker for detection of melanoma-associated angiogenesis. It may be a useful marker for early detection of tumor metastasis.

HUMAN sPECAM-1 ELISA

Cat. No. RBMS229R RUO Other names Platelet endothelial cell adhesion molecule, EndoCAM, CD31 antigen, Leukocyte surface protein Product category Cell adhesion proteins Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.48 to 30 ng/ml Limit of detection 0.06 ng/ml Applications serum, plasma, urine, cell culture supernatant Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

MONKEY sPECAM-1 ELISA

Cat. No. RBMS651R RUO Other names Platelet endothelial cell adhesion molecule, EndoCAM, CD31 antigen, Leukocyte surface protein Product category Cell adhesion proteins, Animal studies Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.48 to 30 U/ml Limit of detection 0.06 U/ml Applications baboon serum 10 µl/well P Sample requirements Storage/Shipping 2–8 °C/Wet ice

HUMAN PEDF ELISA PEDF (50kDa) is syntetized and released by human fetal retinal pigment epithelial cells (RPE) into the interphotoreceptor matrix and is localized to human chromosome 17p. Individuals with metabolic syndrome (NCEP criterion) have significantly higher PEDF values than healthy subjects, suggesting that PEDF is and independent marker of MS with sufficient diagnostic efficacy.

Cat. No. RD191114200R RUO Other names Pigment epithelium-derived factor, Serpin-F1, EPC-1 Product category Energy metabolism and body weight regulation, Others Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.15 to 6 ng/ml Limit of detection 0.045 ng/ml Applications serum, plasma (citrate) Sample requirements 10 µl/well Storage/Shipping 2–8 °C

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HUMAN PENTRAXIN 3 ELISA

Cat. No. RSCPP-PD03-E0R RUO Other names Product category Cardiovascular disease, Immune Response, Infection and Inflammation Assay format Calibration range 0.1 to 20 ng/ml Limit of detection 0.1 ng/ml Applications plasma Sample requirements 10 µl/well Storage/Shipping 2–8 °C

PEPSINOGEN Pepsinogen consists of a single polypeptide chain of 375 amino acids with an average molecular weight of 42 kDa. Pepsinogen I is synthesized at gastric chief cells and mucous neck cells, while pepsinogen II is produced not only by gastric chief cells, mucous neck cells, but also by clear mucous cells of antrum, etc. The clinical applications of measuring pepsinogen I and pepsinogen II are of useful aid in diagnosing severe atrophic gastritis and stomach cancer. It was suggested that the measurement of serum pepsinogens served as a “serological biopsy” for predicting the presence of atrophic gastritis or superficial gastritis. Atrophic Gastritis: It was found that a serum pepsinogen I level below 20 ng/ml was highly specific for severe atrophic gastritis. It is also observed that serum pepsinogen I levels fell with increasing severity of mucosal damage in atrophic gastritis. The diagnostic sensitivity and specificity of serum pepsinogen I level for advanced atrophic corpus gastritis are about 92% and 90% respectively. On the other hand, the decrease in serum pep- sinogen I levels in patients with pernicious anemia and atrophic gastritis was found to be associated with normal or raised pepsinogen II levels. Therefore, a pepsinogen I/pepsinogen II ratio is significantly lower than those with superficial gastritis or normal remnant mucosa. Stomach Cancer: Low serum pepsinogen I levels were found in patients with gastric cancer, with a threefold higher incidence. Other studies have concluded that low serum pepsinogen I levels may identify persons at increased risk for intestinal types of stomach cancer. Duodenal Ulcer: A low serum pepsinogen I level can exclude a diag- nosis of duodenal ulcer. Although a high pepsinogen I level has less clinical useful for establishing the diagnosis of a duodenal ulcer, the combination of of IMMUNOASSAYS hypergastrinemia and a highly elevated serum pepsinogen

HUMAN PEPSINOGEN I ELISA

Cat. No. RIS007R RUO Product category Others Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 3 to 300 ng/ml Limit of detection 0.5 ng/ml Applications serum Sample requirements 25 µl/well Storage/Shipping 2–8 °C

HUMAN PEPSINOGEN II ELISA

Cat. No. RIS008R RUO Product category Others Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 6.3 to 100 ng/ml Limit of detection 0.5 ng/ml Applications serum Sample requirements 50 µl/well Storage/Shipping 2–8 °C

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HUMAN PERFORIN ELISA Perforin has structural and functional similarities to complement component 9 (C9). Like C9, Perforin creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. It is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood.

Cat. No. RGP021R RUO Product category Apoptosis Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 62.5 to 2000 pg/ml Limit of detection < 40 pg/ml Applications buffer solution, cell culture supernatant Sample requirements 100 µl/well Storage/Shipping 2-8 °C/ Wet ice

PERIOSTIN Periostin was originally isolated as an osteoblast-specific factor that functions as a cell adhesion molecule for pre-osteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading. Additionally, periostin expression has previously been shown to be significantly increased by both transforming growth factor β1 (TGF-β1) and bone morphogenetic protein 2 (BMP-2). Abnormal expression of periostin is also linked to angiogenesis and metastasis in epithelial tumors. Periostin up-regulation in cancers usually correlates with aggressiveness and/or poor survival.

HUMAN PERIOSTIN ELISA

Cat. No. RAG019R RUO Other names pre-B cell colony-enhancing factor, PBEF, NAMPT Product category Bone and cartilage metabolism, Cardiovascular disease, Cytokines and chemokines and related molecules Assay format Sandwich ELISA, HRP-labelled antibody

P Calibration range 78 to 5000 pg/ml Limit of detection 15 pg/ml Applications cell culture supernatant, plasma, serum Storage/Shipping 2-8 °C/ Wet ice

MOUSE PERIOSTIN ELISA

Cat. No. RAG020R RUO Other names pre-B cell colony-enhancing factor, PBEF, NAMPT Product category Bone and cartilage metabolism, Cardiovascular disease, Cytokines and chemokines and related molecules Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 31 to 2000 pg/ml Limit of detection 10 pg/ml Applications cell culture supernatant, plasma, serum Storage/Shipping 2-8 °C/ Wet ice

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PEROXIREDOXIN Peroxiredoxin (Prx) is a growing anti-oxidative protein family that has been identified six members in mammals. They share a common reactive Cys residue in the N-terminal region, and are capable of serving as a peroxidase and involve thioredoxin and/or glutathione as the electron donor. Prx1 to Prx4 have an additional Cys residue in the conserved C-terminal region, and are cross members as judged by the amino acid sequence similarity. Prx5 also contains an additional Cys in its C-terminal region that is less conserved. On the other hand, Prx6 has only one unique Cys. These Prx family members are distributed in subcellular localization, Prx1, 2, and 6 in cytosol, Prx3 in mitochondria, Prx4 in ER and secretion, Prx5 showing complicated distribution including peroxi- some, mitochondria and cytosol, all of which are potential sites of ROS production. In addition to their role as a peroxidase, however, a body of evidence has accumulated to suggest that individual members also serve divergent functions, which are associated with various biological processes such as the detoxification of oxidants, cell proliferation, differentiation and gene expression. It would be expected that these functions might not necessarily depend on peroxidase activity and, therefore, it seems likely that the divergence is due to unique molecular characteristics intrinsic to each member.

HUMAN PEROXIREDOXIN 1 ELISA

Cat. No. RLF-EK0131R RUO Other names Prx1 Product category Oxidative stress Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0 to 32 ng/ml Limit of detection 0.5 ng/ml Applications serum, plasma, cell lysate Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN PEROXIREDOXIN 3 ELISA IMMUNOASSAYS

Cat. No. RLF-EK0113R RUO Other names Prx3 Product category Oxidative stress Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0 to 32 ng/ml Limit of detection 2 ng/ml Applications serum, cell lysate Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN PHOSPHORYLATED NEUROFILAMENT H ELISA Neurofilaments are the most abundant protein components of neurons belonging to the intermediate or 10 nm filament protein/gene superfamily. NF-H (heavy) protein is about 200 kDa and contains unusual multiple repeated sequence lysine-serine-proline (KSP), and in axonal neurofilaments essentially all serine residues are heavily phosphorylated. pNF-H released from damaged and diseased axons should remain in fluid undegraded. The detection of pNF-H in blood and CSF points unambiguously to neuronal damage due to the fact that pNF-H is found exclusively in neurons. pNF-H is also detected in the plasma of humans suffering from optic neuritis and in elevated levels in the cerebrospinal fluid (CSF) of individuals suffering from brain tumors and stroke.

Cat. No. RD191138300R RUO Other names pNF-H Product category Neural tissue damage markers Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 62.5 to 4000 pg/ml Limit of detection 23.5 pg/ml Applications cerebrospinal fluid, plasma, serum, tissue extract Storage/Shipping 2–8 °C/Wet ice

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HUMAN PLACENTAL LACTOGEN ELISA The physiological role of human placental lactogen (HPL) has not yet been established, but the great similarity to human growth hormone has stimulated the hypothesis about a function as a regulator of feto-placental growth and other physiological alterations during pregnancy. It has been suggested that the maternal serumlevel may reflect on “index of placental function”. Depressed levels of HPL are seen in association with intrauterine death, fetal distress in labor and birth asphyxia. This association is particularly strong if depressed levels are seen repeatedly, implying a chronic state of placental and therefore fetal compromise. Depressed levels are usually not present if the pregnancy has proceeded uneventfully to term. Elevated levels of HPL are usually indica- tive of optimal pregnancy outcome in singleton pregnancies. However, high levels may indicate substantial fetal pathology in specific diseases, namely diabetes mellitus and fetal macrosomia, rhesus isoimmunization and hydrops fetalis.

Cat. No. RIS0013R RUO Product category Reproduction Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 1.25 to 20 mg/ml Limit of detection 0.3 mg/ml Applications serum Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN PMN ELASTASE ELISA PMN granulocytes use proteinases to digest pathogens (microorganisms and viruses) and tissue debris. PMN elastase is localised in the azurophilic granules of the polymorphonuclear granulocytes. During phagocytosis of foreign substances these enzymes are excreted into the extracellular surrounding, where the activity of PMN elastase is regulated by inhibitors. The concentration of PMN elastase/alpha1-proteinase inhibitor complex can be used as a measure for the activity of granulocytes during an inflammatory response. Enzymatically active PMN elastase can cause local tissue injury. Determinations of PMN elastase find its application in observation of the course of trauma, shock and sepsis.

Cat. No. RD191021100 IVD CE Other names Elastase-2, Leukocyte elastase, Neutrophil elastase Product category Immune Response, Infection and Inflammation Assay format Sandwich ELISA, HRP-labelled antibody

P Calibration range 15.6 to 1000 ng/ml Limit of detection 0.2 ng/ml Applications bronchoalveolar lavage, cerebrospinal fluid, exudate, plasma (citrate, EDTA), seminal plasma Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

PREGNENOLONE ELISA Pregnenolone is the first steroid to be derived from cholesterol in the pathway of steroidogenesis, and it is the common precursor for all of the adrenal and gonadal steroids. Its production occurs in the mitochondrion by cleavage of the C-20 side chain of cholesterol by the P-450SCC enzyme. Elevated preg- nenolone levels occur in forms of congenital adrenal hyperplasia. The determination of pregnenolone in serum may be useful for studying its metabolite, pregnenolone sulfate, which has been reported to have various effects in the mammalian brain and central nervous system.

Cat. No. RCAN-PRE-4500R RUO Other names 3β-hydroxypregn-5-en-20-one Product category Steroid hormones Assay format Competitive ELISA, Immobilized antibody Calibration range 0.1 to 25 ng/ml Limit of detection 0.05 ng/ml Applications serum Sample requirements 50 μl/well Storage/Shipping 2–8 °C/Wet ice

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HUMAN PROCALCITONIN ELISA Procalcitonin (PCT) is the precursor of the hormone calcitonin. PCT can be produced by numerous cell types and organs (mainly by parafollicular cells (C cells) of the thyroid and by the neuroendocrine cells of the lung and the intestine) after proinflammatory stimulation, especially when caused by bacte- rial challenge. Plasma PCT concentrations are found to be below 0.05 ng/ml in healthy people, but values can increase up to 1000 ng/ml in patients with severe sepsis or septic shock. Measurement of procalcitonin can be used as a marker of severe sepsis and generally grades well with the degree of sepsis.

Cat. No. RD191006200R RUO Other names PCT Product category Immune response, infecton and inflammation, Sepsis Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 50 to 3200 pg/ml Limit of detection 12 pg/ml Applications serum, urine Sample requirements serum 50 µl/well, urine 75 μl/well Storage/Shipping 2–8 °C/Wet ice

PROGESTERONE Progesterone is a C-21 female sex steroid hormone with a variety of physiological effects. In the follicular phase of the menstrual cycle, progesterone is produced in low levels. It increases to the LH peak and then sharply rises 3 to 4 days later to higher levels. Progesterone measurements are used in documenting ovulation and in the management of difficulties during the first trimester of pregnancy. Levels of progesterone may be useful in the evaluation of sterility due to luteal phase defects, prediction of impending abortion, and the diagnosis of ectopic pregnancy.

PROGESTERONE ELISA IMMUNOASSAYS Cat. No. RCAN-P-305R RUO Product category Steroid hormones Assay format Competitive ELISA, Immobilized antigen Calibration range 0.3 to 60 ng/ml Limit of detection 0.1 ng/ml Applications serum Storage/Shipping 2–8 °C/Wet ice

MOUSE/RAT PROGESTERONE ELISA

Cat. No. RTC008R RUO Product category Animal studies, Steroid hormones Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.4 to 100 ng/ml Limit of detection 0.04 ng/ml Applications serum, plasma Sample requirements 25 µl Storage/Shipping 2–8 °C/Wet ice

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PROGRANULIN Progranulin has been shown to be a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signal ling cascades that control cell cycle progression and cell motility. Progranulin has also been linked to tumorigenesis. Due to its tumor-promoting activity and multiple functions on hematopoietic cells and endotheial cells, progranulin can be a novel marker for oncology and hematology.

HUMAN PROGRANULIN ELISA

Cat. No. RMEE103R RUO Other names Granulin epithelin precursor, Proepithelin, Acrogranin Product category Energy metabolism and body weight regulation, Neural tissue damage markers Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 75 to 2 500 pg/ml Limit of detection 0.018 ng/ml Applications serum, plasma Sample requirements 10 µl/well Storage/Shipping 2-8 °C/ Wet ice

MOUSE PROGRANULIN ELISA

Cat. No. RAG014R RUO Other names Granulin Epithelin Precursor, Proepithelin, Acrogranin Product category Energy metabolism and body weight regulation, Neural tissue damage markers Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.125 to 8 ng/ml Limit of detection 60 pg/ml Applications serum, cell culture supernatant

P Sample requirements Storage/Shipping 2-8 °C/ Wet ice

RAT PROGRANULIN ELISA

Cat. No. RAG015R RUO Other names Granulin Epithelin Precursor, Proepithelin, Acrogranin Product category Energy metabolism and body weight regulation, Neural tissue damage markers Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.063 to 4 ng/ml Limit of detection 40 pg/ml Applications serum, cell culture supernatant Sample requirements Storage/Shipping 2-8 °C/ Wet ice

166 For more information please go to www.biovendor.com IMMUNOASSAYS

HUMAN PROGUANYLIN ELISA Proguanylin, the 116-amino acid prohormone, is a bioactive form of human guanylin that acts on intestinal guanylate cyclase, thereby regulating intestinal fluid and elektrolyte transport through the second messenger, cyclic GMP (cGMP). The cGMP increase inhibits salt absorption and stimulates chloride secretion into the gut. This imbalance of ions is accompanied by a massive accumulation of water in the gut that gives rise to diarrhea and dehydratation characteristic of enterotoxin activity. Proguanylin is found in circulation and plays an endocrine role by regulating the function of tissues such as the kidney and liver. Proguanylin is a significant marker in renal insufficiency. Plasma levels of proguanylin increase in patients with chronic renal failure who were undergoing hemodialysis. Studies have shown, that serum levels of Proguanylin has rise in patients with Cohn syndrome therefore it could be used as a novel marker in diagnostic and therapy of cardiac failure.

Cat. No. RD191046100CS RUO Guanylate cyclase activator 2A, Guanylate cyclase-activating protein 1, Guanylate cyclase-activating protein I, GCAP-I, GUCA2A, Other names GUCA2 Product category Others, Renal disease Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.3 – 10 ng/ml Limit of detection 0.09 ng/ml Applications serum, plasma Sample requirements 20 µl/well Storage/Shipping 2-8 °C/ Wet ice

HUMAN PROINSULIN INTACT ELISA Proinsulin (86 amino acids -polypeptide), is synthetized in the B cells of the islets of Langerhans in the pancreas. PI is the precursor of insulin which in the principal hormone responsible for the control of glucose metabolism. This protein is cleaved to C-peptide and insulin. Both are secreted in equimolar amounts into the blood. The level of proinsulin in serum can be a reflection of B cell status and a consequence of dysfunction of PI processing and secre-

tion. Proinsulin levels have been shown elevated in diabetics and other clinical situations. IMMUNOASSAYS

Cat. No. RD193094100 IVD CE Other names PI Product category Diabetology Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0 to 100 pmol/l Limit of detection 0.6 pmol/l Applications serum Sample requirements 100 µl/well Storage/Shipping 2–8 °C/Wet ice

PROLACTIN Prolactin (about 24 kDa, 199 amino acids) is a peptide hormone primarily associated with lactation. It is synthesised and secreted by lactotrope cells in the adenohypophysis. It is also produced in other tissues including the breast and the decidua. Prolactin stimulates the mammary glands to produce milk (lactation).

HUMAN PROLACTIN ELISA

Cat. No. RCAN-PRL-4100R RUO Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 20 to 3200 µIU/ml Limit of detection 10 µIU/ml Applications serum Sample requirements 25 µl/well Storage/Shipping 2–8 °C/Wet ice

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RAT PROLACTIN ELISA

Cat. No. RTC006R RUO Product category Animal studies Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 5 to 80 ng/ml Limit of detection 0.6 ng/ml Applications serum, plasma Sample requirements 25 µl Storage/Shipping 2–8 °C/Wet ice

HUMAN PRORENIN ELISA Prorenin is a glycosylated aspartic protease that consists of 2 homologous lobes and is the precursor of renin. Renin activates the renin-angiotensin system by cleaving angiotensinogen, produced by the liver, to yield angiotensin I, which is further converted into angiotensin II by ACE, the angiotensin- converting enzyme primarily within the capillaries of the lungs. It has been reported that the levels of circulating prorenin (but not renin) are increased in diabetic subjects.

Cat. No. RMI001R RUO Product category Blood pressure regulation and NO metabolism, Diabetology, Renal disease Assay format Direct ELISA, HRP-labelled antibody Calibration range 0 to 10 ng/ml Limit of detection 0.013 ng/ml Applications plasma Storage/Shipping 2–8 °C/Wet ice

HUMAN PROSTAGLANDIN D SYNTHASE (LIPOCALIN-TYPE) ELISA Prostaglandin D Synthase catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation­ and a potent P inhibitor of platelet aggregationand and is Involved in a variety of CNS functions, It binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. The urinary and serum levels may provide a sensitive indicator of renal damage in diabetes mellitus and hypertension. Elevated levels in the coronary circulation may also be associated with angina. It may be a specific cell marker for meningioma.

Cat. No. RD191113100R RUO Other names Beta trace protein, BTP, Prostaglandin-H2 D-isomerase, Lipocalin-type prostaglandin D synthase Product category Renal disease, Neural tissue damage markers Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 1 to 40 ng/ml Limit of detection 0.5 ng/ml Applications serum, plasma, cerebrospinal fluid, urine Sample requirements 100 μl/well Storage/Shipping 2–8 °C/Wet ice

168 For more information please go to www.biovendor.com IMMUNOASSAYS

HUMAN PROSTATE SECRETORY PROTEIN 94 ELISA Prostate secretory protein 94 (PSP94) is one of the major secretory proteins of the prostate glands. Evidence suggests that PSP94 has systemic functions including growth regulation and induction of apoptosis in prostate cancer cells in vitro and in vivo, and regulation of calcium levels during hypercalcemia secondary to malignancy. In a recently published study, patients with low total PSP94 levels had a high probability for having prostate cancer detected at biopsy. The total PSP94 level was able to help identify patients with high grade disease among a subset of patients in whom PSA and FTPSA are least informative.

Cat. No. RD191140200R RUO Other names PSP94, β-microseminoprotein, Prostatic inhibin-like protein Product category Oncology, Reproduction Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.5 to 16 ng/ml Limit of detection 0.12 ng/ml Applications serum, plasma Sample requirements 50 µl/ well Storage/Shipping 2-8 °C/ Wet ice

HUMAN PROUROGUANYLIN ELISA Prouroguanylin (about 9, 7 kDa) is a biologically inactive form of uroguanylin circulating in a bloodstream. Uroguanylin is a small –molecular-weight peptide which has been shown to participate in the regulation of salt and water homeostasis in mammals via cGMP-mediated processes in the intestine, kidney and other epithelia. Prouroguanylin levels are markedly increased in chronic renal failure. Uroguanylin/prouroguanylin­ levels also increased in the nephrotic syndrome. Studies of pathogenesis of colorectal cancer demonstrate that prouroguanylin may serve as marker of colon tumors in the body. Recent experiments also refer to possibility of prouroguanylin to play a significant role at diagnostic and treatment of heart diseases.

Cat. No. RD191069200CS RUO IMMUNOASSAYS Guanylate cyclase activator 2B, Guanylate cyclase C-activating peptide 2, Guanylate cyclase C-activating peptide II, GCAP-II, Other names Uroguanylin, UGN, GUCA2B Product category Others, Renal disease Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.8 to 40 ng/ml Limit of detection 0.13 ng/ml Applications serum, plasma Sample requirements 20 µl/well Storage/Shipping 2-8 °C/ Wet ice

HUMAN sPSGL-1 ELISA PSGL-1 a transmembrane protein which forms homodimers via disulfide bridges of two 120 kDa chains. It is expressed on cells of myeloid, lymphoid and dendritic lineage.

Cat. No. RBMS255R RUO Other names P-selectin glycoprotein ligand 1, CD162 antigen Product category Cell adhesion proteins Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 1.6 to 50 U/ml Limit of detection 0.99 U/ml Applications serum, cell culture supernatant Sample requirements 100 µl/well (1:20 prediluted) Storage/Shipping 2–8 °C/Wet ice

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PEPTIDE YY (PYY) PYY was isolated from the extract of pig duodenum and shown to be a polypeptide consisting of 36 amino acids residues. PYY is homologous to pancreatic polypeptide and neuropeptide Y. PYY is localized mainly in endocrine cells in the intestine. PYY shows an inhibitory action on contraction of the gastrointes- tinal tract and on secretion of pancreatic and gastric juice. PYY is released by taking diet.

HUMAN PYY ELISA

Cat. No. RSCYK080R RUO Other names Peptide YY Product category Energy metabolism and body weight regulation Assay format Competitive ELISA, Immobilized antibody Calibration range 0.14 to 100 ng/ml Applications plasma Sample requirements 25 μl/well Storage/Shipping 2–8 °C/Wet ice

RAT PYY ELISA

Cat. No. RSCYK081R RUO Other names Peptide YY Product category Energy metabolism and body weight regulation, Animal studies Assay format Competitive ELISA, Immobilized antibody Calibration range 0.14 to 100 ng/ml Applications plasma Sample requirements 25 μl/well Storage/Shipping 2–8 °C/Wet ice

P–R RAT QUALITY CONTROL SET (CORTICOSTERONE, PROLACTIN, TESTOSTERONE, TSH) According to the respective package insert of the BioVendor ELISA kits Mouse/Rat Corticosterone (RTC002R), Rat Prolactin (RTC006R), Mouse/Rat Testos- terone (RTC001R) and Rat Thyroid Stimulating Hormone (RTC007R) the control can be used for internal quality control. The procedure calls for equivalent sample volume per test.

Cat. No. RTC900R RUO Storage/Shipping 2–8 °C/Wet ice Content 1 Set 2 vials à 1 ml

HUMAN sRAGE ELISA The receptor for advanced glycation end products (RAGE) is a multiligand member of the immunoglobulin superfamily of cell surface molecules. It medi- ates interactions of advanced glycation end products (AGE), the products of nonenzymatic glycoxidation of proteins/lipids that accumulate in the plasma and tissues of patients with diabetes. Therefore, RAGE is connected to diseases and pathological states (e.g., diabetic complication, vascular and inflam- matory diseases). Decreased level of sRAGE is a biomarker for deficient and/or altered inflammatory control in humans. It was shown that reduced level of sRAGE is associ- ated with higher risk of coronary disease. In Alzheimer disease there is a decrease in serum sRAGE in comparison with patients with vascular dementia and controls. In essential hypertensia, it has been shown that sRAGE concentration in serum was inversely associated with pulse pressure. On the other hand, an increased level of serum sRAGE was found in patients with end-stage renal disease and acute lung injury.

Cat. No. RD191116200R RUO Other names Advanced glycation end product-specific receptor Product category Diabetology, Renal disease Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 50 to 3 200 pg/ml Limit of detection 19.2 pg/ml Applications serum, plasma Sample requirements 50 μl/well Storage/Shipping 2–8 °C/Wet ice

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HUMAN sRANKL (TOTAL) ELISA (OSTEOPROTEGERIN LIGAND) sRANKL (Osteoprotegerin ligand), a member of the TNF superfamily, is the key molecular regulation system for bone modelling. It is the main stimulatory factor for the formation of mature osteoclasts and is essential for their survival. RANKL is produced by osteoblastic lineage cells and activated T lympho- cytes. Imbalances of the RANKL/OPG system have been related to the pathogenesis of Pagets disease, bone tumors, postmenopausal osteopororsis, rheumatoid arthritis, bone metastases and hypercalcemia.

Cat. No. RD193004200R RUO Other names soluble RANKL Receptor, TNF11 Product category Bone and cartilage metabolism Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.5 to 32 pmol/l Limit of detection 0.4 pmol/l Applications serum, plasma Sample requirements 5 µl/well Storage/Shipping 2–8 °C/Wet ice

RBP4 Retinol binding protein (RBP) 4 is the only specific transport protein for vitamin A in the circulation whose function is to deliver vitamin to target tissues (1). In obesity and type 2 diabetes, expression of Glut4 is significantly impaired in adipocytes. Glucose transport via Glut4 is the rate-limiting step for glucose use by muscle and adipose tissue (2). Yang et al. noted that adipocyte-specific deletion of Gluts led to notable elevation of RBP4 causing systemic insulin resistance, and that reduction of RBP4 improved insulin resistance (3). This identified a novel role of RBP4 in regulating insulin action and RBP4 is recorded as an adipocyte-derived hormone. Thus, measurement of serum or plasma RBP4 is a useful means for understanding of metabolic disorders.

HUMAN RBP4 ELISA IMMUNOASSAYS

Cat. No. RAG005R RUO Other names Plasma retinol-binding protein, PRBP, RBP, RBP4, PRO2222 Product category Energy metabolism and body weight regulation, Diabetology Assay format Competitive ELISA, Immobilized antigen Calibration range 0.001 to 5 μg/ml Limit of detection 1 ng/ml Applications serum, urine, plasma, cell culture supernatant Storage/Shipping 2–8 °C/Wet ice

MOUSE/RAT RBP4 ELISA

Cat. No. RAG007R RUO Other names Plasma retinol-binding protein, PRBP, RBP, RBP4, PRO2222 Product category Energy metabolism and body weight regulation, Diabetology Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.188 to 12 ng/ml Limit of detection 60 pg/ml Applications serum, urine, cell culture supernatant Storage/Shipping 2–8 °C/Wet ice

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HUMAN RENIN ELISA Renin, a polypeptidic enzyme (MW~40000) also known as angiotensinogenase, is a circulating protease secreted by juxtaglomerular cells in the juxtaglo- merular apparatus of the kidneys in response to low blood volume or low body NaCL content. Renin activates the renin-angiotensin system by cleaving an- giotensinogen produced in the liver into angiotensin I (inactive) which is further converted into angiotensin II (active) in the vascular epithelium of the lung. Angiotensin II can cause vasoconstriction by stimulating the central nervous system , in addition it stimulates ADH (antidiuretic hormone) secretion and aldosterone secretion from the adrenal gland.Regulation of blood pressure and renal glomerular filtration control are the most important functions of renin -angiotensin system . Plasmatic concentration of renin is influenced by concentration of circulating angiotensinogen and subsequently the concentration of angiotensin II. High plasmatic levels of angiotensin II reduce renin secretion.(negative feed back) Determination of renin plasma levels is useful in the diagnosis of hypertension and in the therapeutic follow up of hypertensive patients. Plasmatic concentration of renin decreases in patients with hyperten- sion due to a primary hyperaldosteronism , contrary to renovascular hypertension where concentrations of renin and aldosterone are both elevated.

Cat. No. RIS004R RUO Other names HNFJ2, REN Product category Blood pressure regulation and NO metabolism, Cardiovascular disease, Renal disease, Diabetology Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0 to 270 pg/ml Limit of detection 0.8 pg/ml Applications plasma (EDTA) Sample requirements 200 µl/well Storage/Shipping 2–8 °C/Wet ice

RESISTIN Resistin, a product of the RSTN gene, is a peptide hormone belonging to the class of cysteine-rich secreted proteins. Resistin is an adipocytokine whose physiologic role has been the subject of much controversy regarding its involvement with obesity and type II diabetes mellitus (T2DM). Resistin was origi- nally found to be produced and released from adipose tissue to serve endocrine functions likely involved in insulin resistance. Further research has linked resistin to other physiological systems such as inflammation and energy homeostasis.

HUMAN RESISTIN ELISA

Cat. No. RD191016100 IVD CE R–S Other names RSTN, ADSF, FIZZ3, Adipose Tissue-Specific Secretory Factor Product category Energy metabolism and body weight regulation Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 1 to 50 ng/ml Limit of detection 0.012 ng/ml Applications serum, plasma Sample requirements 35 µl/well Storage/Shipping 2–8 °C/Wet ice

MOUSE RESISTIN ELISA

Cat. No. RD293016100R RUO Other names RSTN, ADSF, FIZZ3, Adipose Tissue-Specific Secretory Factor Product category Energy metabolism and body weight regulation, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 2 to 100 ng/ml Limit of detection 5 pg/ml Applications serum, plasma (EDTA, citrate), cell culture medium Sample requirements 5 µl/well Storage/Shipping 2–8 °C/Wet ice

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RAT RESISTIN ELISA

Cat. No. RD391016200R RUO Other names RSTN, ADSF, FIZZ3, Adipose Tissue-Specific Secretory Factor Product category Energy metabolism and body weight regulation, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.25 to 20 ng/ml Limit of detection 0.05 ng/ml Applications serum Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

RHEUMATOID FACTOR Rheumatoid factor (RF) is an antibody against the Fc portion of IgG, which is itself an antibody, IgM or IgA type; RF and IgG form immune complexes, which are part of the disease process of various rheumatological diseases. Rheumatoid factor (RF) blood test is performed in patients with suspected rheuma- toid arthritis.

MOUSE IgG RHEUMATOID FACTOR ELISA

Cat. No. RSHAKRRG101R RUO Other names RF-IgM, RF-IgG Product category Animal studies

Assay format Direct ELISA, HRP-labelled antibody IMMUNOASSAYS Calibration range 15.6 to 1 000 mU/ml Limit of detection 0.78 mU/ml Applications serum, plasma (EDTA, citrate) Sample requirements 1 μl/well Storage/Shipping 2–8 °C/Wet ice

MOUSE IgM RHEUMATOID FACTOR ELISA

Cat. No. RSHAKRRG111R RUO Other names RF-IgM, RF-IgG Product category Animal studies Assay format Direct ELISA, HRP-labelled antibody Calibration range 15.6 to 1 000 mU/ml Limit of detection 0.78 mU/ml Applications serum, plasma (EDTA, citrate) Sample requirements 1 μl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN S100A5 ELISA

Cat. No. RD191212200CS RUO Other names S100 calcium-binding protein A5, Protein S-100D Product category Oncology, Others Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.0625 to 2 ng/ml Limit of detection 0.02 ng/ml Applications serum, plasma Sample requirements 20 µl/well Storage/Shipping 2–8 °C/Wet ice

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HUMAN S100A6 ELISA (MULTISPECIES SPECIFICITY) S100A6, also known as calcyclin, is member of the S100 family of Ca2+-binding proteins. Similar to other members of this family, S100A6 contains two EF-hand motifs that bind kalcium ions. The S100A6 protein, similar to other S100 proteins, forms homodimers and each subunit binds two calcium ions. Ca2+-binding induces conformational changes in the molecule but these structural changes are modest when compared with other Ca2+-sensing proteins, such as calmodulin. S100A6 is most abundantly expressed in fibroblasts and epithelial cells and has also been found in some neurons, astrocytes, smooth muscle cells, cardiac myocytes, platelets and lymphocytes. S100A6 is predominantly a cytoplasmic protein. In the presence of calcium ions, S100A6 might also associ- ate with cell membranes, especially the plasma membrane and the nuclear envelope. Nuclear localization of S100A6 has also been reported. The precise biological function of S100A6 has not yet been described. It was originály suggested that S100A6 has a role in cell-cycle progression. This hypothesis was supported by the fact that S100A6 was found to be upregulated in multiple tumors. S100A6 also inhibits the interaction between the heat shock proteins (Hsp70 and Hsp90), which suggests a potential role for S100A6 in the cellular response to different stress factors. Physiological stimuli which increase S100A6 expression include platelet-derived grow factor (PDGF), epidermal growth factor (EGF), serum, retinoic acid, estrogen, palmitate, vasopressin and gastrin. S100A6 levels are also up-regulated upon stress conditions such as ischemia, mechanical force, irradiation and oxidative stress. In vivo studies have demonstrated that S100A6 protein levels are elevated in myocardial diseases and in many types of tumor cells.

Cat. No. RD191215200R RUO S100 calcium-binding protein A6, Calcyclin, Prolactin receptor-associated protein, PRA, Growth factor-inducible protein 2A9, Other names MLN 4, CACY Product category Immune Response, Infection and Inflammation, Neural tissue markers, Oncology, Others Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.125 to 4 ng/ml Limit of detection 0.014 ng/ml Applications serum, plasma (heparin), urine, cerebrospinal fluid, bronchoalveolar lavage, tissue extract Sample requirements Storage/Shipping 2–8 °C/Wet ice

HUMAN S100A11 ELISA (MULTISPECIES SPECIFICITY) S100A11 (S100C; calgizzarin) was first isolated from chicken gizzard smooth muscle. Human homologue was later identified in human colorectal cancer cells and in colorectal normal mucosa, with much higher expression in the cancer cells. S100A11 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. The polypeptide chain consists of 105 amino acid residues giving molecular weight of unmodified monomeric protein 11.74 kDa. Disulphide bridge linking two monomers in the dimer via Cys-11 residues was found in its structure. The protein can be phosphorylated on S some residues from which at least phosphorylation on Thr-10 causes significant structural changes. S100A11 binds to annexins A1 and A2, the DNA- dependent ATPase Rad54B, p53 and RAGE. It was proposed that up-regulated chondrocyte expression of S100A11 (as RAGE ligand) in OA cartilage and RAGE signaling through the p38 MAPK pathway promote inflammation-associated chondrocyte hypertrophy. RAGE signaling mediated by S100A11 thereby might have the potential to contribute to the progression of OA. S100A11 has also been shown to be secreted and to exert RAGE dependent signaling in human keratinocytes. S100A11 was found in many different human both normal and cancer tissues. S100A11 appears to play distinct roles depending on the tumour involved. In bladder carcinoma or renal carcinoma expression is related to tumour suppression however in prostate cancer, breast and pancreatic cancer S100A11 is thought to be a tumour promoter. S100A11 has been also indicated as one of potential biomarkers of infective endocarditis.

Cat. No. RD191220100R RUO S100 calcium-binding protein A11, Protein S100-C, Calgizzarin Metastatic lymph node gene 70 protein, MLN 70, S100A11, Other names MLN70, S100C Product category Cardiovascular disease, Oncology, Others Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.313 to 100 ng/ml Limit of detection 0.01 ng/ml Applications amniotic fluid, bronchoalveolar lavage, serum Sample requirements Storage/Shipping 2–8 °C/Wet ice

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HUMAN S100A12 ELISA The S100A12 (EN-RAGE, calgranulin) is a member of the S100 protein family, which, in humans, consists of twenty five EF-hand (alpha helix-loop-alpha helix), calcium-binding proteins, of which the vast majority is in homodimer, heterodimer or more complex form. The mature S100A12 consists of 91 amino acids (Mr 10,444 Da), is predominantly expressed and secreted by neutrophil granulocytes and at a lower extent, it was found in monocytes. Hofmann et al. (1999) reported that RAGE is a central cell surface receptor for S100A12, which they referred to as EN-RAGE (Extracellular Newly identified RAGE-binding protein), and related members of the S100/calgranulin superfamily. Interaction of EN-RAGE (S100A12) with cellular RAGE on endothelium, mononuclear phagocytes, and lymphocytes triggered cellular activation, with generation of key proinflammatory mediators. In murine models, blockade of EN-RAGE/RAGE quenched delayed-type hypersensitivity and inflammatory colitis by arresting activation of central signaling pathways and expression of inflammatory gene mediators. In regard to its inflammatory properties, S100A12 was already described as promising marker for many diseases in hu- man such as neurodegenerative diseases, atherosclerosis, cancerogenesis, osteoarthritis, familial mediterranean fever, idiopathic pulmonary fibrosis, and plasma S100A12 level is associated with cardiovascular disease in hemodialysis patients.

Cat. No. RD191221200R RUO S100 calcium-binding protein A12, Calgranulin-C, CAGC, CGRP, Neutrophil S100 protein, Calcium-binding protein in amniotic Other names fluid 1, CAAF1, p6, Extracellular newly identified, RAGE-binding protein, EN-RAGE Product category Oncology, Others Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range Limit of detection 0.02 ng/ml Applications amniotic fluid, bronchoalveolar lavage, serum, urine Sample requirements Storage/Shipping 2–8 °C/Wet ice

HUMAN S100B ELISA S100B, dimeric, acidic protein, a member of highly homologous Ca2+ binding proteins family, is expressed in vertebrates - in astrocytes, oligodendrocytes and Schwann cells. S100 proteins are involved in the inhibition of protein phosphorylation, inhibition of cytoskeletal constituent assembly, regulation of IMMUNOASSAYS Ca2+ homeostasis, stimulation of enzyme activities, and interaction with transcription factors. High (micromolar) concentrations of S100B are neurotoxic and can induct neurodegenerative disorders. The clinical values of S100B have been demon- strated in stroke, cerebral complications associated with cardiac arrest and in patients with severe as well as minor head injury. Patients with progressive melanoma disease have been also shown to have elevated serum levels of S100B.

Cat. No. RD192090100R RUO Product category Neural tissue damage markers, Oncology Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.05 to 2 ng/ml Limit of detection 15 pg/ml Applications serum, plasma (heparin), cerebrospinal fluid Sample requirements 25 µl/well Storage/Shipping 2–8 °C/Wet ice

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HUMAN S100G ELISA S100G (S100 calcium binding protein G, Calbindin 3 (CALB3), CaBP9K, CABP1) is a member of the S100 family of calcium-binding proteins. The gene encoding human S100G is located on the X-chromosome (Xq22) and consists of three exons and contains four Alu repeats. The S100G protein (molecular weight 9 kDa) is monomeric and contains two Ca2+ binding motifs, a classical C-terminal EF-hand with a canonical Ca2+ binding loop and an S100- specific N-terminal EF-hand with a modified Ca2+ binding loop called ‘‘pseudo EF-hand’’. S100G protein is present in many organs, cartilage, bone and certain teeth, such as the ameloblasts of incisors and molars. In addition, S100G mRNA is detected in the proximal small intestine, but not in human kidney, uterus or placenta (however, the protein is present in these tissues in other species). S100G is also present in mammalian intestinal epithelial cells (enterocytes). S100G mediates the transport of calcium across the enterocytes from the apical side, where entry is regulated by the calcium chan- nel TRPV6, to the basolateral side, where calcium pumps such as PMCA1 utilize intracellular adenosine triphosphate to pump calcium into the blood. The transport of calcium across the enterocyte cytoplasm appears to be rate-limiting for calcium absorption in the intestine; the presence of calbindin increases the amount of calcium crossing the cell without raising the free concentration. Expression of S100G, like that of calbindin-D28k, is stimulated by the active vitamin D metabolite, calcitriol although the precise mechanisms are still controversial. In mice that lack the receptor for vitamin D, S100G is reduced, but not absent. The members of the S100 family are multifunctional signaling proteins that influence with many cellular events. S100G appear to be involved in neurotrophic and/or neuroprotective processes, but the mechanisms of action are not completely understood. S100G has protective neurotrophic effects during brain development, and alterations in level may serve as an early, quantitative indicator of fetal brain damage in some biologi- cal fluids (eg, cord blood). Calcium-regulatory molecule S100G is dynamically expressed and regulated in the uterine endometrium during pregnancy and suggesting that regulation of calcium ion concentration may be critical for the establishment and maintenance of pregnancy in pigs.

Cat. No. RD191225200R RUO S100 calcium-binding protein G, Vitamin D-dependent calcium-binding protein intestinal, CABP, Calbindin-D9k, CABP9K, Other names CALB3, S100D Product category Cardiovascular disease, Oncology, Others Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 25 to 800 pg/ml Limit of detection 7.7 pg/ml Applications plasma, serum Sample requirements 5 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN SDMA ELISA SDMA is eliminated from the body exclusively by renal excretion; therefore SDMA plasma concentration is tightly related to renal function. Elevated SDMA

S levels may prospectively indicate future risk of cardiovascular disease and mortality independently of the level of renal impairment.

Cat. No. REA203/96 IVD CE Other names Symmetric Dimethylarginine Product category Blood pressure regulation and NO metabolism Assay format Competitive ELISA, Immobilized antigen Calibration range 0.08 to 3 µmol/l Limit of detection 0.05 μmol/l Applications serum, plasma (EDTA) Sample requirements 20 μl/well Storage/Shipping 2–8 °C/Wet ice

sE-SELECTIN E-selectin belongs to the selectin family of adhesion molecules. Together with LECAM-1 (L-selectin) and GMP-140 (P-selectin), E-selectin mediates the initial interactions of leukocytes and platelets with endothelial cells. E-selectin is expressed on cytokine-activated endothelial cells, and contributes to the adhesion of resting leukocytes to the endothelium. Determination of sE-selectin could provide more detailed insights into the pathological modifications during various diseases.

HUMAN sE-SELECTIN ELISA Cat. No. RBMS205R RUO Other names ELAM1, endothelial adhesion molecule 1, CD62E Product category Immune Response, Infection and inflammation, Cell adhesion proteins, Transplantation Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.8 to 50 ng/ml Limit of detection 0.33 ng/ml Applications serum, plasma, cell culture supernatant Sample requirements 20 µl/well Storage/Shipping 2–8 °C/Wet ice

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MONKEY sE-SELECTIN ELISA

Cat. No. RBMS649R RUO Other names Endothelial Leukocyte Adhesion Molecule-1, ELAM-1, Leukocyte endothelial cell adhesion molecule 2, LECAM2, CD62E antigen Product category Animal studies, Immune Response, Infection and inflammation, Cell adhesion proteins, Transplantation Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.94 to 60 U/ml Limit of detection 0.39 U/ml Applications baboon serum Sample requirements 20 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN sL-SELECTIN ELISA Determination of soluble/circulating L-selectin could provide more detailed insights into the pathological modifications during various diseases: - allergy: L-selectin expression is down-modulated on eosinophils recovered from bronchoalveolar lavage fluid after allergen provocation. - bronchoalveolar lavage (BAL): BAL transiently promotes PMN/monocyte activation and recruitment to the bronchoalveolar space. The cells respond with a complete shedding of L-selectin when they extravasate from the blood into the bronchoalveolar space. - deep venous thrombosis (DVT): A case can be made for the participation of PMN‘s in the initiation and propagation of venous thrombosis. Probably via L-selectin leukocytes adhere to areas of veins that serve as sites for initiation of thrombi. - HIV: patients suffering from HIV-infection showed markedly elevated levels of sL-selectin in serum. - insulin-dependent diabetes mellitus (IDDM): serum levels of L-selectin were found to be elevated in IDDM patients and in subjects at risk for developing IDDM. - Kawasaki Syndrome: sL-selectin levels seem to be less than those of normals. - malignant B-cell populations: B-cell chronic lymphocytic leukaemia, hairy cell leukaemia and mantle zone lymphoma are L-selectin positive.

- neonatal bacterial infection: in case of intra-uterine infection lymphocytes obtained from cord blood have a diminished L-selectin expression. This is IMMUNOASSAYS independent of gestational age, birth weight, umbilical artery pH, hematocrit, leukocyte count, absolute neutrophil count, CRP-level or maternal fever. - sepsis: patients suffering from sepsis showed markedly elevated levels of sL-selectin in serum. Vascular endothelial injury observed in overwhelming sep- sis may be caused by neutrophil-derived enzymes. Adherence to endothelium is a prerequisite for this process. Measurement of sL-selectin may provide further insights into the interrelationship between neutrophil activation and endothelial damage in gram-negative sepsis. - surgery: patients undergoing cardiopulmonary bypass surgery may develop an acute post-operative capillary leak, due to endothelial injury inflicted by adherent neutrophils. In those patients L-selectin is completely lost in a small but progressively increasing proportion of PMN‘s, which could be responsi- ble for the endothelial damage.

Cat. No. RBMS206R RUO Other names Leukocyte adhesion molecule 1, LAM-1, Leukocyte surface antigen Leu-8, Leukocyte-endothelial cell adhesion molecule 1, LECAM-1, Lymph node homing receptor, Lymphocyte adhesion molecule 1, CD62L Product category Cell adhesion proteins Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.39 to 25 ng/ml Limit of detection 0.19 ng/ml Applications serum, cell culture supernatant Sample requirements 50 µl/well (1:100 prediluted) Storage/Shipping 2–8 °C/Wet ice

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P-SELECTIN P-selectin belongs to the selectin family of adhesion molecules. P-selectin acts as a receptor that supports binding of leukocytes to activated platelets and endothelium. P-selectin-mediated adhesive interactions operate in conjunction with cell-cell interactions directed by related molecules and are likely to be important in both hemostatic and inflammatory processes. The physiological role of P-selectin may be the mediation of initial leukocyte adhesion to activated endothelium during acute inflammation. Soluble P-selectin is a potentially important molecule that may provide more detailed insight into pathological situations.

HUMAN sP-SELECTIN ELISA

Cat. No. RBMS219/4R RUO Other names Granule membrane protein 140, PADGEM, CD62P Product category Cell adhesion proteins Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.63 to 40 ng/ml Limit of detection 0.20 ng/ml Applications serum, plasma, cell culture supernatant Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

MONKEY sP-SELECTIN ELISA

Cat. No. RBMS650/4R RUO Other names Granule membrane protein 140, PADGEM, CD62P Product category Cell adhesion proteins, Animal studies Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.8 to 50 U/ml Limit of detection 1.3 U/ml Applications cell culture supernatant, baboon serum S Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN SECRETAGOGIN ELISA Secretagogin is a Ca-binding protein characterised by molecular weight of 32 kDa. Secretagogin is expressed in central nervous system, and it seems to be involved in several pathological conditions in the CNS, such as epilepsy or neurodegenerative disorders, for example Alzheimer´s disease. Recent study shown, that secretagogin is detectable in human serum after ischemic brain demage, under specific pathological condition associated with neuronal death and impairment of the blood-brain barrier. Additionally, its strong expression in insulin secreting cells, its influence on insulin expression might contribute to insuline homeostasis.

Cat. No. RD191120200R RUO Other names SCGN, SEGN, CALBL, Setagin Product category Diabetology, Neural tissue markers, Oncology Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 62.5 to 2000 pg/ml Limit of detection 11 pg/ml Applications serum, plasma (EDTA) Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

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HUMAN SEX HORMONE BINDING GLOBULIN ELISA Sex-hormone-binding globulin (SHBG) is a β-globulin that specifically binds steroid hormones. Its molecular weight is 86 kDa/mol. The major site of SHBG synthesis is thought to be the hepatocytes. Its production is regulated by androgen/estrogen balance, thyroid hormones, insulin and dietary factors, among others. SHBG is involved in the transport of sex steroids in plasma. Its concentration is a major factor regulating their distribution between protein-bound and free states. Determination of SHBG concentration is mainly of importance in the evaluation of mild disorders of androgen metabolism and it allows identification of women with hirsutism who are likely to respond to estrogen therapy. Testosterone/SHBG-ratios correlate well with both measured and calculated values for free testosterone, and help to discriminate between subjects with excessive androgen activity and normal individuals.

Cat. No. RCAN-SHBG-4010R RUO SHBG, Sex steroid-binding protein, Testis-specific androgen-binding protein, Testosterone-estradiol-binding globulin, Testoster- Other names one-estrogen-binding globulin Product category Reproduction, Steroid hormones Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 3.3 to 295 nmol/l Limit of detection 0.1 nmol/l Applications serum Sample requirements 20 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN SPERM-ANTIBODY ELISA

Cat. No. RIS0017R RUO Other names Anti-Spermatozoa Antibody, Anti-Sperm Antibody Product category Reproduction IMMUNOASSAYS Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 62 to 500 U/ml Limit of detection Applications serum Sample requirements 5 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN STEM CELL FACTOR RECEPTOR (CD117) ELISA Stem cell factor is a cytokine that binds to the c-Kit receptor (CD117). This cytokine plays an important role in hematopoiesis (formation of blood cells), spermatogenesis, and melanogenesis.

Cat. No. RGP005R RUO Other names SCFR, Proto-oncogene c-Kit, Tyrosine-protein kinase Kit Product category Cell surface proteins (sCD) Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.312 to 10 ng/ml Limit of detection < 0.095 ng/ml Applications serum, plasma, cell culture supernatant Sample requirements 100 µl/well Storage/Shipping 2-8 °C/ Wet ice

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SUPEROXIDE DISMUTASE Superoxide dismutase (SOD) is an antioxidant enzyme involved in the defense system against reactive oxygen species (ROS). SOD catalyzes the dismuta- tion reaction of superoxide radical anion (O2-) to hydrogen peroxide, which is then catalyzed to innocuous O2 and H2O by glutathione peroxidase and catalase. Several classes of SOD have been identified. : Cu/Zn SOD (SOD1) is localized in cytosol, Mn SOD (SOD2) in mitochondria, and ecSOD (SOD3) in extracellular space.

HUMAN SUPEROXIDE DISMUTASE 1 ELISA

Cat. No. RLF-EK0101R RUO Other names SOD1, Cu/Zn SOD Product category Oxidative stress Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0 to 800 pg/ml Limit of detection 12.5 pg/ml Applications serum, cell lysate, plasma Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN SUPEROXIDE DISMUTASE 2 ELISA

Cat. No. RLF-EK0104R RUO Other names SOD2, Mn SOD Product category Oxidative stress Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0 to 1600 pg/ml Limit of detection 25 pg/ml Applications serum, cell lysate, plasma

S Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN SUPEROXIDE DISMUTASE 3 ELISA

Cat. No. RLF-EK0107R RUO Other names SOD3 Product category Oxidative stress Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0 to 128 ng/ml Limit of detection 2 ng/ml Applications cell lysate Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

180 For more information please go to www.biovendor.com IMMUNOASSAYS

HUMAN SURFACTANT PROTEIN A ELISA Surfactant Protein A (SP-A) is assembled from six subunits containing two types of polypeptide chains; each subunit has one SP-A1 chain and two SP-A2 chains, which are each composed of 248 amino acid residues (35 kDa), held together by disulphide bonds. SP-A, the major protein component of the lung surfactant of mammals, belongs to the collectins’ family, due to its C-type lectin domain and the collagen-like N-terminal triple helix. Human SP-A is expressed mostly in alveolar type II cells and also in non-ciliated bronchial epithelial cells. Nevertheless, SP-A has been found in various biological fluids, such as bronchoalveolar lavage fluid, sputum, serum, amniotic fluid and vaginal lavage fluid. SP-A is considered to be one of important host defence com- ponents against respiratory allergens and pathogens. SP-A has been suggested to play an anti-inflammatory role but under some circumstances also pro- inflammatory roles in the lung. Changes in the SP-A production in the lung or its baseline concentrations in the blood might be associated with progression and/or mortality in some pulmonary diseases.

Cat. No. RD191139200R RUO Other names SP-A Product category Immune Response, Infection and Inflammation, Reproduction Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 1 to 50 ng/ml Limit of detection 0.16 ng/ml Applications amniotic fluid, bronchoalveolar lavage, plasma (citrate, heparin), serum Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN SURFACTANT PROTEIN D ELISA SP-D (three 43 kDa units), a member of the collagenous subfamily of glycoproteins and calcium-dependent lectins, is synthesized and secreted in the peripheral airway, by alveolar type II and Clara cells. In the lungs, SP-D participates in the innate response to inhaled microorganism and organic antigens. SP-D serum level is a disease marker in cystic fibrosis, acute interstitial pneumonias, bronchopulmonray dysplasia and alveolar proteinosis. IMMUNOASSAYS Cat. No. RD194059101 IVD CE Other names SP-D Product category Immune Response, Infection and Inflammation Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 1.56 to 100 ng/ml Limit of detection 0.01 ng/ml Applications serum, plasma, bronchoalveolar lavage, amniotic fluid Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN SYNDECAN-1 (CD138) ELISA The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. It is a useful marker for plasma cells,but only if the cells tested are already known to be derived from blood.

Cat. No. RGP009R RUO Product category Cell surface proteins (sCD), Oncology Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 8 to 256 ng/ml Limit of detection < 2.56 ng/ml Applications serum, plasma, cell culture supernatant Sample requirements 100 µl/well Storage/Shipping 2-8 °C/ Wet ice

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HUMAN t-PA ELISA t-PA is a serine protease which occurs in blood plasma, serum, other body fluids, tissues and conditioned media of certain cultured cells. It can convert the inactive proenzyme plasminogen to the active protease plasmin. t-PA is described as a factor correlating to the risk of development of cardiovascular disease in long-term dialysis patients.

Cat. No. RBMS258/2R RUO Other names Tissue-type plasminogen activator Product category Others Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 15.6 to 1000 pg/ml Limit of detection 6.4 pg/ml Applications serum, cell culture supernatant Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

TESTOSTERONE Testosterone is the most important male sex hormone, it is responsible for genital development, beard growth, muscle development and general male characteristics. The measurement of serum or plasma levels is an index of leydig cell function and high or low values correlate well with hypo or hyper gonadism. In females small amounts of testosterone are produced by the adrenals and ovaries. High levels of testosterone in females indicates excessive androgen production and are found in progressive hirsutism and virilization, Cushing’s syndrome and a deficiency in one or more of the specific enzymes required for normal steroid biosynthesis.

TESTOSTERONE ELISA

Cat. No. RCAN-TE-250R RUO Product category Steroid hormones Assay format Competitive ELISA, Immobilized antigen Calibration range 0.08 to 16 ng/ml T Limit of detection 0.022 ng/ml Applications serum Sample requirements 50 μl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN FREE TESTOSTERONE ELISA

Cat. No. RCAN-FTE-260R RUO Product category Steroid hormones Assay format Competitive ELISA, Immobilized antigen Calibration range 0.25 to 125 pg/ml Limit of detection 0.17 pg/ml Applications serum Sample requirements 25 µl/well Storage/Shipping 2–8 °C/Wet ice

MOUSE/RAT TESTOSTERONE ELISA

Cat. No. RTC001R RUO Product category Animal studies, Steroid hormones Assay format Competitive ELISA, Immobilized antigen Calibration range 0.1 to 25 ng/ml Limit of detection 0.066 ng/ml Applications serum, plasma Sample requirements 10 µl Storage/Shipping 2–8 °C/Wet ice

182 For more information please go to www.biovendor.com IMMUNOASSAYS

HUMAN sTfR ELISA TfR is the gateway for transferrin-bound-iron entering all body cells. The erythroid marrow cells account for 70 to 80 % of the total body TfR content. sTfr (85 kDa) is a circulating truncated form of the membrane receptor protein. The serum sTfR concentration reflects the total body mass of cellular transfer- rin receptor. Anaemias associated with enhanced erythropoiesis and iron deficiency result in an elevation in the sTfR values. The clinical use of the sTfR determination in in the differential diagnosis between iron deficiency anemia and the anemia of chronic disease.

Cat. No. RD194011100 IVD CE Other names Soluble Transferrin Receptor Product category Iron metabolism Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.05 to 2 µg/ml Limit of detection 2 ng/ml Applications serum, plasma Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

TGF-BETA1 TGF-beta belongs to a family of dimeric 25 kDa polypeptides that are ubiquitously distributed in tissues and synthesized by many different cells. TGF-β1 inhibits T- and B cell proliferation and inhibits maturation and activation of macrophages. It furthermore inhibits activity of natural killer cells and lym- phokine activated killer cells and blocks production of cytokines.

HUMAN TGF-BETA1 ELISA

Cat. No. RBMS249/4R RUO IMMUNOASSAYS Other names Transforming growth factor beta 1 Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 31.0 to 2000 ng/ml Limit of detection 8.6 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 40 µl/well (pretreated) Storage/Shipping 2–8 °C/Wet ice

MOUSE TGF-BETA1 ELISA

Cat. No. RBMS608/4R RUO Other names Transforming growth factor beta 1 Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 31.25 to 2000 ng/ml Limit of detection 12 pg/ml Applications serum, plasma (EDTA, citrate), cell culture supernatant Sample requirements 10-40 µl/well (pretreated) Storage/Shipping 2–8 °C/Wet ice

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RAT TGF-BETA1 ELISA

Cat. No. RBMS623/2R RUO Other names Transforming growth factor beta 1 Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 31.25 to 2000 pg/ml Limit of detection 12 pg/ml Applications serum, plasma (EDTA, citrate), cell culture supernatant Sample requirements 100 µl/well (pretreated) Storage/Shipping 2–8 °C/Wet ice

HUMAN TGF-BETA2 ELISA TGF-beta belongs to a family of dimeric 25 kDa polypeptides that are ubiquitously distributed in tissues and synthesized by many different cells. TGF-β2 is a potent cytokine which has been shown to modulate embryonic development, bone formation, mammary development, wound healing, hematopoiesis, cell cycle progression and the production of the extracellular matrix.

Cat. No. RBMS254R RUO Other names Transforming growth factor beta-2 Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 31.3 to 1000 pg/ml Limit of detection 6.6 pg/ml Applications serum, cell culture supernatant Sample requirements 100 µl/well (1:100 prediluted) Storage/Shipping 2–8 °C/Wet ice T HUMAN THIOREDOXIN 1 ELISA Thioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox- active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cysteine residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds. Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations. Specific protein disulfide targets for reduction by Trx include protein disulfide –isomerase (PDI) and a number of transcription factors such as p53, NFkB and AP-1 (T1–151). Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins.

Cat. No. RLF-EK0125R RUO Other names Trx Product category Oxidative stress Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.39 – 25 ng/ml Limit of detection 0.39 ng/ml Applications Buffer solution, Cell culture lysate Storage/Shipping 2–8 °C/Wet ice

184 For more information please go to www.biovendor.com IMMUNOASSAYS

HUMAN THIOREDOXIN REDUCTASE 1 ELISA The mammalian thioredoxin reductases(TrxRs) are a family of selenocysteine-containing pyridine nucleotide-disulfide oxido-reductases. Three different TrxR isoenzymes, TrxR1 as cytosolic, TrxR2 as mitochondrial, and TrxR3 as testis-specific thiol regulator are known. All the mammalian TrxRs are homologous to glutathione reductase with respect to primary structure including the conserved redox catalytic site (-Cys-Val-Asn-Val-Gly-Cys-) but distinctively with a C-terminal extension containing a catalytically active penultimate selenocysteine(SeCys)­ residue in the conserved sequence(-Gly-Cys-SeCys-Gly). TrxR is homodimeric protein in which each monomer includes an FAD prosthetic group, a NADPH binding site and a redox catalytic site. Electrons are transferred from NADPH via FAD and the active-site disulfide to C-terminal SeCys-containing redox center, which then reduces the substrate like thioredoxin. The mem- bers of TrxR family are 55–58 kDa in molecular size and composed of three isoforms including cytosolic TrxR1, mitochondrial TrxR2, and TrxR3, known as Trx and GSSG reductase(TGR). TrxR plays a key role in protection of cells against oxidative stress and redox-regulatory mechanism of transcription factors and various biological phenomena. Many tumor cells have elevated TrxR levels and TrxR has been shown to play a major role in drug resistance. Inhibition of TrxR and its related redox reactions may thus contribute to a successful single, combinatory or adjuvant cancer therapy. A great number of effective natural and synthetic TrxR inhibitors are now available possessing antitumor potential ranging from induction of oxidative stress to cell cycle arrest and apoptosis.

Cat. No. RLF-EK0122R RUO Other names TR1 Product category Oxidative stress Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0 to 25 ng/ml Limit of detection 0.39 ng/ml Applications serum, cell lysate, plasma Sample requirements 100 µl/well (1:100 prediluted) Storage/Shipping 2–8 °C/Wet ice

HUMAN THROMBOMODULIN (CD141) ELISA Thrombomodulin (CD141) is a 557 amino acid a glycosylated transmembrane protein and is a thrombin receptor located on endothelial cell surface. This surface glycoprotein forms a complex with thrombin that activates protein C, which, in turn, degrades clotting factors V and VIII. Thus, thrombomodulin IMMUNOASSAYS converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems.

Cat. No. RGP003R RUO Other names Cluster of differentiation 141, BDCA-3 Product category Cell surface proteins (sCD) Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.625 to 20 ng/ml Limit of detection < 0.38 ng/ml Applications serum, plasma, cell culture supernatant Sample requirements 100 µl/well Storage/Shipping 2-8 °C/ Wet ice

THYROID STIMULATING HORMONE Thyroid stimulating hormone (TSH) is a glycoprotein hormone secreted by the anterior pituitary gland. TSH has two subunits, namely α and β. The α subunit of TSH is similar to the α subunit found in the LH, FSH and hCG glycoprotein hormones. However, the β subunit is specific and differs from hormone to hormone. The thyroid hormones are secreted and produced by the thyroid gland. The production of thyroid hormones is under the regulation of TSH. Also, TSH acts as a stimulator of iodide transport and the gland itself is under the positive control of TSH. The concentrations of thyroid hormones control the secretion of TSH, therefore, a negative feedback exists. It is to be noted that the secretion of thyroid hormones are under the direct, positive effect of the sympathetic nervous system. The major protein component of the thyroid gland is thyroglobulin, a glycoprotein of which the secretion in the blood stream is stimulated by TSH. There- fore, TSH plays an important role in the proper function and development of the thyroid gland. It is recommended to assay both the glycoprotein hormone and the target organ hormones. For example, in primary hypothyroidism the serum level of thyroxine is low while the TSH level is high. In secondary hypothyroidism, both thyroxine and TSH are low. The TSH level is decreased in hyperthyroidism. Today, with all the sensitive assays available, if there were to be only one test to be prescribed for thyroid function, TSH would be the test. TSH determinations are also helpful to monitor patients who receive thyroxine replacement therapy.

HUMAN THYROID STIMULATING HORMONE ELISA

Cat. No. RCAN-TSH-4080R RUO Other names TSH, Thyrotropin Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.2 to 30 µIU/ml Limit of detection 0.1 µIU/ml Applications serum Sample requirements 50 µl Storage/Shipping 2-8 °C/ Wet ice [email protected] 185 IMMUNOASSAYS

RAT THYROID STIMULATING HORMONE ELISA

Cat. No. RTC007R RUO Other names TSH, Thyrotropin Product category Animal studies Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 2.5 to 80 ng/ml Limit of detection 0.1 ng/ml Applications serum Sample requirements 25 µl Storage/Shipping 2-8 °C/ Wet ice

THYROXINE Thyroxine (T4), the principal thyroid hormone, circulates in blood almost completely bound to carrier proteins. However, only the free (unbound) fraction of thyroxine is considered to be biologically active. The main carriers of thyroxine are thyroxine-binding globulin (TBG), pre-albumin and albumin. The measure- ment of free thyroxine (fT4) levels correlate better with the clinical status than total thyroxine levels.

HUMAN FREE THYROXINE ELISA

Cat. No. RCAN-FT4-4340R RUO Other names fT4 Product category Others Assay format Competitive ELISA, Immobilized antigen Calibration range 2 to 95 pg/ml Limit of detection 1 pg/ml Applications serum Sample requirements 25 µl/well T Storage/Shipping 2-8 °C/ Wet ice

HUMAN THYROXINE TOTAL ELISA

Cat. No. RCAN-T4-4240R RUO Other names T4 Product category Others Assay format Competitive ELISA, Immobilized antigen Calibration range 1 to 32 µg/dl Limit of detection 0.6 µg/dl Applications serum Sample requirements 20 µl/well Storage/Shipping 2-8 °C/ Wet ice

HUMAN TIE-2 ELISA TIE-2 was initially identified as a specific endothelial growth factor receptor that mediated several properties of endothelial cells under both physiologcal and pathological conditions. TIE-2 plays an important role in several vascular diseases, known as vascular malformation (e.g. venous malformation).

Cat. No. RBMS2042R RUO Other names Angiopoietin-1 receptor, Tyrosine-protein kinase receptor TEK Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.16 to 10.0 ng/ml Limit of detection 0.03 ng/ml Applications serum, plasma, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

186 For more information please go to www.biovendor.com IMMUNOASSAYS

HUMAN TIMP-1 ELISA This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types and may also have an anti-apoptotic function.

Cat. No. RBMS2018R RUO Other names Tissue inhibitor of metalloproteinases, EPA Product category Others Assay format Sandwich ELISA, 2nd HRP-labelled antibody Calibration range 39 to 2500 pg/ml Limit of detection 10.0 pg/ml Applications serum, plasma (EDTA, heparin), cell culture supernatant Sample requirements 20 µl/well (1:100 prediluted) Storage/Shipping 2–8 °C/Wet ice

TNF-ALPHA TNF-α (17.5 kDa, 157 amino acid) is a non-glycosylated protein that is a potent lymphoid factor, which exerts cytototic effects on a wide range of tumor cells and other target cells. It is secreted by macrophages, monocytes, neutrophils, T-cells, NK-cells following their stimulation by bycterial lipopolysaccha- rides. TNF-α has been suggested to play a pro-inflammatory role and has been detected in synovial fluid of patients with rheumatoid arthritis.

HUMAN TNF-ALPHA ELISA

Cat. No. RBMS223/4R RUO Other names Tumor necrosis factor alpha, Cachectin IMMUNOASSAYS Product category Cytokines, chemokines and related molecules, Energy metabolism and body weight regulation Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 7.8 to 500 pg/ml Limit of detection 2.3 pg/ml Applications serum, plasma, urine, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN TNF-ALPHA TOTAL ELISA

Cat. No. RBMS2034R RUO Other names Tumor necrosis factor alpha, Cachectin, DIF Product category Cytokines, chemokines and related molecules, Energy metabolism and body weight regulation Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 23 to 1 500 pg/ml Limit of detection 5.0 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

MONKEY TNF-ALPHA ELISA

Cat. No. RBMS654R RUO Other names Tumor necrosis factor alpha, Cachectin, DIF Product category Cytokines, chemokines and related molecules, Energy metabolism and body weight regulation, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 28.1 to 1800 U/ml Limit of detection 6.0 U/ml Applications baboon serum, cell culture supernatant, cynomolgus serum Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice [email protected] 187 IMMUNOASSAYS

MOUSE TNF-ALPHA ELISA

Cat. No. RBMS607/3R RUO Other names Tumor necrosis factor alpha, Cachectin, DIF Product category Cytokines, chemokines and related molecules, Energy metabolism and body weight regulation, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 31.3 to 2 000 pg/mL Limit of detection 3.7 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

RAT TNF-ALPHA ELISA

Cat. No. RBMS622R RUO Other names Tumor necrosis factor alpha, Cachectin Product category Animal studies, Cytokines, chemokines and related molecules, Energy metabolism and body weight regulation Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 39.1 to 2500 pg/ml Limit of detection 11 pg/ml Applications cell culture supernatant, serum Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN TNF-BETA ELISA TNF-beta is a potent mediator of inflammatory and immune responses. It belongs to the TNF family of ligands and signals through TNFR1 and TNFR2. TNF- beta is produced by activated T and B lymphocytes, and has similar activities to TNF-alpha. Like TNF-alpha, TNF-beta is involved in the regulation of various T biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. TNF-beta is secreted as a soluble polypeptide, but can form heterotrimers with lymphotoxin-beta, which effectively anchors the TNF-beta to the cell surface. TNF-beta is cytotoxic to a wide range of tumor cells.

Cat. No. RBMS202R RUO Other names Lymphotoxin-alpha, TNF superfamily member 1 Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 7.8 to 1000 pg/ml Limit of detection 4.6 pg/ml Applications serum, cell culture supernatant Sample requirements 100 µl/well Storage/Shipping 2–8 °C/Wet ice

188 For more information please go to www.biovendor.com IMMUNOASSAYS

TNF-R TNF alpha exerts many of its effects by binding, as a trimer, to either a 55 kDa cell membrane receptor termed TNFR-1 or a 75 kDa cell membrane receptor termed TNFR-2. Both these receptors belong to the so-called TNF receptor superfamily. Tumor Necrosis Factor (TNF) was originally discovered in sera of ani- mals and was found to cause hemorrhagic necrosis of some transplantable mouse and human tumors and to exhibit primarily cytotoxic activities against tumor but not normal cells in vitro. The TNF family consists of two proteins designated TNFα, also called cachectin, and TNFβ, also called lymphotoxin, which are pleiotropic cytokines that can mediate a wide variety of biological effects.

HUMAN sTNF-R (60 kDA) ELISA

Cat. No. RBMS203R RUO Other names Tumor necrosis factor receptor 1, TNF-R1, CD120a Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.08 to 5 ng/ml Limit of detection 0.05 ng/ml Applications serum, urine, plasma, cell culture supernatant Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN sTNF-R (80 kDA) ELISA

Cat. No. RBMS211R RUO Other names TNFR2, Tumor necrosis factor receptor 2, CD120b

Product category Cytokines, chemokines and related molecules IMMUNOASSAYS Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.16 to 10 ng/ml Limit of detection 0.10 ng/ml Applications serum, urine, plasma, cell culture supernatant Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

MONKEY sTNF-R I ELISA

Cat. No. RBMS653R RUO Other names TNFR1, Tumor necrosis factor receptor superfamily member 1A, p60, p55, CD120a antigen, TNFRSF1A Product category Animal studies, Cytokines, chemokines and related molecules Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.09 to 6 U/ml Limit of detection 0.05 U/ml Applications baboon serum Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice

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HUMAN TRAIL ELISA TRAIL is a member of the TNF family which mediates cell death in a wide variety of malignant cell lines and primary tumor cells. It induces two different signals: cell death mediated by caspases and gene induction mediated by NFkappaB. TRAIL, which is ubiquitously expressed, exhibits very complex signal- ling and tumor-selective induction of apoptosis. TRAIL is involved in lymphatic neoplastic disorders and thyroid diseases and in the treatment of cancer like melanoma.

Cat. No. RBMS2004R RUO Other names TNF-related apoptosis-inducing ligand Product category Oncology, Apoptosis Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 15.6 to 1000 pg/ml Limit of detection 5.0 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

TRAIL RECEPTOR Human Trail R1 (R2) is a TNF receptor , which is a receptor for Trail (APO2 ligand). Trail R1 and R2 are involved in apoptosis. In the Trail receptor family, Trail R1, but also Trail R2 transduce an apoptosis signal, whereas Trail R3 and Trail R4 antagonize TRAIL-induced apoptosis.

HUMAN TRAIL RECEPTOR 1 (CD261) ELISA

Cat. No. RGP022R RUO Other names Death receptor 4, DR4 Product category Apoptosis Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 31.25 to 1000 pg/ml

T Limit of detection < 8 pg/ml Applications serum, cell lysates ,cell culture supernatant Sample requirements 100 µl/well Storage/Shipping 2-8 °C/ Wet ice

HUMAN TRAIL RECEPTOR 2 (CD262) ELISA

Cat. No. RGP023R RUO Other names Death receptor 5, DR5, TRICK 2, Apo2 Product category Apoptosis Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 31.25 to 1000 pg/ml Limit of detection < 6 pg/ml Applications serum, cell lysates ,cell culture supernatant Sample requirements 100 µl/well Storage/Shipping 2-8 °C/ Wet ice

HUMAN TRAIL RECEPTOR 3 (CD263) ELISA

Cat. No. RGP024R RUO Other names DcR1, LIT, TRID Product category Apoptosis Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 312.5 to 10000 pg/ml Limit of detection < 147 pg/ml Applications serum, cell lysates Sample requirements 100 µl/well Storage/Shipping 2-8 °C/ Wet ice

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HUMAN TRAIL RECEPTOR 4 (CD264) ELISA

Cat. No. RGP025R RUO Other names DcR2, TRUNND Product category Apoptosis Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 312.5 to 10000 pg/ml Limit of detection < 64 pg/ml Applications serum, cell lysates Sample requirements 100 µl/well Storage/Shipping 2-8 °C/ Wet ice

RAT TRANSFERRIN ELISA Transferrin (around 80 kDa) is a blood plasma protein for iron ion delivery. It is a glycoprotein, which binds iron very tighly but reversibly. Transferrin is as- sociated with the immune system. It is found in the mucosa. A deficiency is associated with atransferrinemia.

Cat. No. RSCPRG091R RUO Product category Iron metabolism, Animal studies Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.63 to 20 ng/ml Applications serum, plasma, urine, faeces Sample requirements 100 μl/well Storage/Shipping 2–8 °C/Wet ice IMMUNOASSAYS

HUMAN TRAP 5 ASSAY TRAP 5 (35-37 kDA), the most abundant enzyme in osteoclasts, is expressed in certain differentiated cells of the mononuclear phagocyte system, particu- larly osteoclasts and alveolar macrophages, where it takes an active part in bone resorption process. High blood levels of TRAP 5 are usually associated with active bone remodelling. Specific determination of TRAP 5 activity can be essential for clinical assessment of bone metabolism.

Cat. No. RD197025000 IVD CE Other names TRACP 5, Tartrate Resistant Acid Phosphatase 5 Product category Bone and cartilage metabolism Assay format Immunocapture enzyme activity assay Calibration range 0.2 to 4 U/l Limit of detection 0.01 U/l Applications serum, plasma (EDTA) Sample requirements 25 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN TREFOIL FACTOR 1 ELISA Trefoil factor 1 (TFF1) is a small secreted protein belonging to the TFF protein family. A study examining people with Crohn's disease and inflammatory bow- el disease showed that TFF1 level in serum is increased during the inflammatory state. TFF1 is also highly expressed in the trachea and its level increases after administration of allergen, indicating thatTFF1 could be associated with asthma. Another study found that TFF1 levels are high in septic patients and that the level correlates with prognosis of the septic state. High levels of TFF1 in serum were also found in patients with prostate and other types of cancer (breast, colon and ovarian tumors) but its prognostic value has not yet been proved.

Cat. No. RD191158100R RUO Other names TFF1, pS2 protein, PNR-2 Product category Immune response, infection and inflammation, Energy metabolism and body weight regulation, Oncology, Sepsis Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.125 to 4 ng/ml Limit of detection 0.019 ng/ml Applications serum, plasma, bronchoalveolar lavage Sample requirements 40 µl/ well Storage/Shipping 2-8 °C/ Wet ice [email protected] 191 IMMUNOASSAYS

HUMAN TREFOIL FACTOR 2 ELISA Trefoil factor 2 (TFF2) is a small secreted protein belonging to the TFF protein family. A study examining people with Crohn´s disease and inflammatory bowel disease showed that TFF2 level in serum is increased during the inflammatory state. Another study found that TFF2 levels are high in septic patients and that the level correlates with prognosis of the septic state. High expression of TFF2 was also found in skeletal muscle, liver, heart, spleen, thymus, lymph nodes and bone marrow. The exact function of TFF2 has not yet been revealed, but there is an evidence that it is connected with modulation of im- mune response (TFF2 deficient mice revealed significant change in expression of several genes involved in MHC class I antigen presentation), allergy and asthma (upregulation of TFF2 by diverse antigens). High levels of TFF2 in serum were also found in patients with prostate and other types of cancer (breast, colon and ovarian tumors) but its prognostic value has not yet been proved.

Cat. No. RD191159100R RUO Other names TFF2, PSP, Pancreatic spasmolytic polypeptide Product category Immune response, infection and inflammation, Energy metabolism and body weight regulation, Oncology, Sepsis Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.25 to 10 ng/ml Limit of detection 0.044 ng/ml Applications serum, plasma, bronchoalveolar lavage Sample requirements 40 µl/ well Storage/Shipping 2-8 °C/ Wet ice

HUMAN TREFOIL FACTOR 3 ELISA Trefoil factor 3 (TFF3) belongs together with TFF1 and TFF2 to a small group of mucin-associated peptides. Over-expression of TFF3 occurs at the sites of damage of the gastrointestinal tract, e.g. peptic ulcer or inflammatory bowel disease. TFF3 was reported to be over-expressed also in patients with various neoplasms including intestinal, pancreatic and prostate carcinomas. On the contrary, its expression decreases in thyroid follicular carcinomas.

Cat. No. RD191160200R RUO Other names TFF3, Intestinal trefoil factor, hP1.B, hITF, Polypeptide P1.B, ITF, TFI Product category Energy metabolism and body weight regulation, Oncology, Renal disease, Sepsis Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 2.4 to 0.075 ng/ml T Limit of detection 0.007 ng/ml Applications serum, plasma, urine, bronchoalveolar lavage Sample requirements 25 µl/well Storage/Shipping 2–8 °C/Wet ice

TRIIODOTHYRONINE Triiodothyronine (T3) is a thyroid hormone found circulating in the bloodstream. T3 contains three iodine atoms and is produced largely through the extrathyroidal conversion of thyroxine (T4), the principal thyroid hormone with four iodine atoms. Most of the T3 that circulates in the blood is bound to carrier proteins such as TBG, pre-albumin and albumin. The free fraction of T3 (fT3), which represents only 0.25% of the total amount, is considered to be the physiological active fraction. Total T3 levels depend not only on thyroid status and the peripheral conversion of T4 to T3, but also on the concentration of thyroid hormone-binding proteins. Free T3 (fT3) on the other hand, is largely unaffected by variations in these carrier proteins which can occur under conditions such as pregnancy, estrogen therapy and the use of oral contraceptives. Therefore, free T3 typically reflects a patient’s actual thyroid status more reliably than total T3. Measurement of free T3 is generally recommended for patients with symptoms of hyperthyroidism as found in Graves' disease, toxic adenoma and toxic multinodular goiter.

HUMAN FREE TRIIODOTHYRONINE ELISA

Cat. No. RCAN-FT3-4230R RUO Other names fT3 Product category Others Assay format Competitive ELISA, Immobilized antigen Calibration range 1 to 40 pg/ml Limit of detection 0.3 pg/ml Applications serum Sample requirements 25 µl/well Storage/Shipping 2–8 °C/Wet ice

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HUMAN TRIIODOTHYRONINE TOTAL ELISA

Cat. No. RCAN-T3-4220R RUO Other names T3 Product category Others Assay format Competitive ELISA, Immobilized antigen Calibration range 0.2 to 10 ng/ml Limit of detection 0.16 ng/ml Applications serum Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN TROPONIN I ELISA Troponin I consists of 181–211 amino acid residues, and the cardiac isoform is larger due to the presence of an additional N-terminal peptide which has a biologically important function in the interactions of troponin I and troponin C. The main function of troponin I is the inhibition of actomyosin ATPase activity. Cardiac troponin I and T are sensitive biomarkers of myocardial injury and have become central to the diagnosis of myocardial infarction. They are elevated in many clinical syndromes associated with direct myocardial injury, myocardial ischemia, or ventricular strain. They are also released in a number of clinical situations in which thrombotic complications of coronary artery disease. These situations include conditions like pulmonary embolism, sepsis, myocarditis, and acute stroke.

Cat. No. RLF-EK0128R RUO Product category Cardiovascular disease Assay format Sandwich ELISA, Biotin-labelled antibody

Calibration range 0 to 25 ng/ml IMMUNOASSAYS Limit of detection 0.38 ng/ml Applications serum, plasma, cell lysate Storage/Shipping 2–8 °C/Wet ice

TSH RECEPTOR AUTOANTIBODY Hyperthyroidism in Graves’ disease is due to the presence of autoantibodies to TSHR and measurement of these autoantibodies can be useful in disease diagnosis and management.

HUMAN TSH RECEPTOR AUTOANTIBODY ELISA 2. GENERATION

Cat. No. RTRE/96/2AR RUO Other names TRAb Product category Autoimmunity Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 1 to 40 U/l Limit of detection 0.21 U/ml Applications serum Sample requirements 100 μl/well Storage/Shipping –20 °C

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HUMAN TSH RECEPTOR AUTOANTIBODY ELISA 3. GENERATION

Cat. No. RTRE/96/3AR RUO Other names TRAb Product category Autoimmunity Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.4 to 30 U/l Limit of detection 0.08 U/l Applications serum Sample requirements 100 μl/well Storage/Shipping –20 °C

UROCORTIN Urocortin is a novel predicted neuropeptide belongs to the corticotropin-releasing factor family. It consisting of 38 amino acid residues. Urocortin 2 is expressed in the mouse cardiomyocytes. Ucn2 treatment augmented heart rate, exhibited potent inotropic and lusitropic actions on the left ventricle, and induced a downward shift of the diastolic pressure-sample requirements relation. Urocortin 2 also reduced systemic arterial pressure. Ucn3 was expressed in pancreatic beta-cells and in a mouse beta cell line, MIN6. High potassium or high glucose could stimulate Ucn3 secretion from these cells.

MOUSE UROCORTIN 2 ELISA

Cat. No. RSCYK190R RUO Other names Ucn2, Stresscopin-Related Peptide Product category Animal studies Assay format Competitive ELISA, Immobilized antibody Calibration range 0.82 to 200 ng/ml Applications serum, plasma Sample requirements 20 μl/well Storage/Shipping 2–8 °C/Wet ice T–V

MOUSE/RAT UROCORTIN 3 ELISA

Cat. No. RSCYK200R RUO Other names Ucn3, Stresscopin, SCP Product category Animal studies Assay format Competitive ELISA, Immobilized antibody Calibration range 0.41 to 100 ng/ml Applications serum, plasma, brain tissue extracts Sample requirements 25 μl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN UROMODULIN ELISA Uromodulin is an 85-kDa glycoprotein that is produced in the thick ascending limb of Henle´s loop and early distal convoluted tubules of the nephron. Mutations in the uromodulin gene are associated with three autosomal dominant tubulo-interstitial nephropathies such as familial juvenile hyperuricemic nephropathy (FJHN), medullary cystic kidney disease (MCKD2) and glomerulocystic kidney disease (GCKD). These disorders are characterized by juvenile onset of hyperuricemia, gout and progressive renal failure.

Cat. No. RD191163200R RUO Other names Tamm-Horsfall urinary glycoprotein, THP, UMOD Product category Renal disease Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.5 to 32 ng/ml Limit of detection 0.12 ng/ml Applications serum, plasma, urine Sample requirements 10 μl/well Storage/Shipping 2-8 °C/ Wet ice

194 For more information please go to www.biovendor.com IMMUNOASSAYS

HUMAN sVAP-1 ELISA The mature VAP-1 molecule is a 170 kDa homodimeric glycoprotein that consists of two 90 kDa subunits held together by disulfide bonds. VAP-1 has a large extracellular domain, a single-pass transmembrane domain, and a short cytoplasmic tail. The molecule has abundant sialic acid decorations that are essential to its adhesive function, because VAP-1 is unable to mediate lymphocyte adhesion to desialylated vessels. The leukocyte ligand for VAP-1 is currently unknown. Induction of VAP-1 has been shown at sites of inflam-mation, such as in inflammatory bowel diseases and chronic dermatoses, where expression of VAP-1 is clearly increased. It is constitutively expressed on hepatic endothelium playing a critical role in regulation of T-cell recirculation to the liver. Strong expression of VAP-1 on tumor endothelium distinguishes human hepatocellular carcinomas from colorectal hepatic metastases.

Cat. No. RBMS259R RUO Other names Vascular adhesion protein 1, copper-containing 3 Product category Cell adhesion proteins Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 31.3 to 2000 pg/ml Limit of detection 19 pg/ml Applications serum, plasma (EDTA, heparin), amniotic fluid, cell culture supernatant Sample requirements 10 µl/well (1:100 prediluted) Storage/Shipping 2–8 °C/Wet ice

HUMAN VASPIN ELISA Vaspin is a member of the serine protease inhibitor family. Vaspin was found to be expressed in the visceral adipose tissues of OLETF rats, an animal model of metabolic syndrome. Vaspin is also found in serum, where its concentration is associated with obesity and impaired insulin sensitivity. Low concentrations of vaspin were found in lean subjects and in people with long-term physical training and serum vaspin was increased in obese subjects following weightloss caused by exercise. Determining vaspin levels could be useful when obesity, insulin sensitivity and other links with metabolic syndrome are studied. IMMUNOASSAYS Cat. No. RD191097200R RUO Other names Visceral adipose tissue-derived serpin A12 Product category Energy metabolism and body weight regulation, Reproduction, Diabetology Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.031 to 2 ng/ml Limit of detection 0.01 ng/ml Applications serum, plasma (EDTA, heparin) Sample requirements 80 μl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN sVCAM-1 ELISA VCAM-1 is a member of the immunoglobulin gene superfamily. It is present on tissue macrophages, dendritic cells, bone marrow fibroblasts, myoblasts and myotubes. Increased levels of sVCAM-1 can be detected in several diseases: cancer, autoimmune diseases, infections, inflammation and others.

Cat. No. RBMS232R RUO Other names Vascular cell adhesion protein 1, CD106 antigen Product category Cell adhesion proteins Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 3.15 to 100 ng/ml Limit of detection 0.6 ng/ml Applications serum, plasma, cell culture supernatant Sample requirements 100 µl/well (1:50 prediluted) Storage/Shipping 2–8 °C/Wet ice

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VE-CADHERIN VE-cadherin (about 130 kDa) belongs to the Cadherin adhesion molecules responsible for cellular interactions. VE-cadherin gene encodes a Ca2+- dependent cell adhesion molecule required for the organization of interendothelial junctions. This gene is expressed in endothelial cells.

HUMAN sVE-CADHERIN ELISA

Cat. No. RBMS253R RUO Other names Cadherin-5, Vascular endothelial-cadherin, 7B4 antigen, CD144 antigen Product category Cell adhesion proteins Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.16 to 10 ng/ml Limit of detection 0.15 ng/ml Applications serum, cell culture supernatant Sample requirements 20 µl/well Storage/Shipping 2–8/-20 °C

MONKEY sVE-CADHERIN ELISA

Cat. No. RBMS652R RUO Other names Cadherin-5, Vascular endothelial-cadherin, 7B4 antigen, CD144 antigen Product category Cell adhesion proteins, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.19 to 12.5 U/ml Limit of detection 0.10 U/ml Applications baboon serum Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice V

VEGF VEGF is characterized by its highly specific mitogenic activity in endothelial cells and its angiogenic effect observed in vitro and in vivo. The VEGF family consists of four isoforms (A-D). VEGF-A is considered the most important of these with respect to tumor angiogenesis. The splice variant isoforms VEGF121 and VEGF165 were found to be secreted by a wide spectrum of cell types, including smooth muscle cells, fibroblasts, epithelial cells, keratinocytes, macrophages, cardiac myocytes and various tumor cells. Inhibition of VEGF with a specific monoclonal antibody can suppress tumor growth in vivo.

HUMAN VEGF-A ELISA

Cat. No. RBMS277/2R RUO Other names Vascular endothelial growth factor A,VPF Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 15.6 to 1000 pg/ml Limit of detection 7.9 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

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MOUSE VEGF-A ELISA

Cat. No. RBMS619/2R RUO Other names Vascular endothelial growth factor A,VPF Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 62.5 to 4000 pg/ml Limit of detection 20.0 pg/ml Applications serum, plasma (EDTA), cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN VEGF-C ELISA

Cat. No. RBMS297/2R RUO Other names Vascular endothelial growth factor C, Flt4 ligand Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.23 to 15 ng/ml Limit of detection 0.057 ng/ml Applications serum, plasma, cell culture supernatant Sample requirements 20 µl/well Storage/Shipping 2–8 °C/Wet ice IMMUNOASSAYS

RAT VEGF-C ELISA

Cat. No. RBMS626/2R RUO Other names Vascular endothelial growth factor C, Flt4 ligand Product category Cytokines, chemokines and related molecules, Animal studies Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 47 to 3000 pg/ml Limit of detection 27 pg/ml Applications serum, plasma (heparin), cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

HUMAN sVEGF-R1/FLT-1 ELISA Soluble VEGF-R1 is a naturally occurring endogenous form of the VEGF-R1 and was originally found in the supernatant of human vascular endothelial cells. It is generated by differential splicing of the flt-1 gene. In vitro sVEGF-R1 is used to inhibit VEGF-A mediated signals in endothelial cells, and in vivo it can be used to block physiological angiogenesis in several organs (e.g. ovary or bones).

Cat. No. RBMS268/3R RUO Other names Tyrosine-protein kinase receptor FLT, FLT-1 Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.16 to 10 ng/ml Limit of detection 0.03 ng/ml Applications serum, cell culture supernatant Sample requirements 50 µl/well Storage/Shipping 2–8 °C/Wet ice

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HUMAN VEGF-R2/KDR ELISA VEGFR-2 is the major mediator of the mitogenic, angiogenic and permeability-enhancing effects of VEGF-A. Alternative splicing or proteolytic processing of VEGFR’s give rise to secreted variants of VEGFR-2, also called soluble VEGFR-2 (sVEGFR-2). Besides its putative role as a surrogate marker for tumour angiogenesis, naturally occurring sVEGFR-2 is a molecular regulator for VEGF and VEGFR signalling. Further investigations will reveal if sVEGFR-2 can arrest solid tumour angiogenesis and modulate metastasis.

Cat. No. RBMS2019R RUO Other names FLK1, Kinase insert domain receptor, CD309 Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 78 to 5 000 pg/ml Limit of detection 7.0 pg/ml Applications serum, plasma, cell culture supernatant Sample requirements 50 µl/ well Storage/Shipping 2-8 °C/ Wet ice

HUMAN VEGF-R3/FLT-4 ELISA VEGF-R3 is widely expressed in the early embryo but becomes restricted to lymphatic endothelia at later stages of development. It is likely that VEGF-R3 may be important for lymph angiogenesis.

Cat. No. RBMS2064R RUO Product category Cytokines, chemokines and related molecules Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.6 to 40 ng/ml Limit of detection 0.03 ng/ml Applications serum, plasma (citrate), cell culture supernatant Sample requirements 50 µl/ well Storage/Shipping 2-8 °C/ Wet ice V

HUMAN VILIP-1 ELISA VILIP-1 is a cytoplasmic protein of low molecular weight (approximately 22 kDa) consisting of 191 amino acid residues. It is found primarily in the brain, in nerve cells, but it also has a peripheral distribution in liver, lung, kidney, spleen, pancreas and colon. VILIP-1 has been identified as a potential biomarker for brain injury and several neurodegenerative diseases. VILIP-1-expressing cells appear to be vulnerable to neurotoxic insults. The protein is released into the cerebrospinal fluid (CSF), and can be used as a biomarker for stroke and Alzheimer’s disease. In Alzheimer’s disease, CSF levels of VILIP-1 were signifi- cantly higher than in healthy individuals and the protein associated with extracellular amyloid plaques and neurofibrillar tangles.

Cat. No. RD191119200R RUO Other names Visinin-like protein 1, Hippocalcin-like protein 3, HLP3, VLP-1, VSNL1, VISL1 Product category Neural tissue damage markers, Oncology Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 0.1 to 5 ng/ml Limit of detection 0.027 ng/ml Applications serum, plasma, cerebrospinal fluid, tissue extract Sample requirements 100 µl/well Storage/Shipping 2–8 °C/Wet ice

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VISFATIN Visfatin, also known as pre-B cell colony-enhancing factor (PBEF), is a cytokine that is highly expressed in visceral fat and was originally isolated as a secreted factor that synergizes with IL-7 and stem cell factors to promote the growth of B cell precursors. Visfatin homologs have been identified in carp, invertebrate mollusks , and bacteria, as well as in vertebrates, including humans and the mouse. It has been postulated to play a role in innate immunity. Visfatin exerts insulin-mimetic effects that are dose-dependent and quantitatively similar to those of insulin in stimulating muscle and adipocyte glucose transport, and in inhibiting hepatocyte glucose production. Intravenous injection of recombinant visfatin in mice decreased plasma glucose in a dose- dependent fashion. In keeping with its insulin-mimetic effects, visfatin was as effective as insulin in reducing hyperglycemia in insulin-deficient diabetic mice. Visfatin was also found to be bound to and activate insulin receptor, causing receptor phosphorylation and the activation of downstream signaling molecules. However, visfatin and insulin did not compete for binding to the insulin receptor, indicating that the two proteins were recognized by different re- gions of the receptor. Thus, visfatin might play a role in glucose homeostasis and dysregulation in biosynthesis or signal transduction, and might contribute to the pathogenesis of diabetes.

HUMAN VISFATIN (NAMPT) ELISA

Cat. No. RAG004R RUO Pre-B cell colony-enhancing factor, PBEF, Nicotinamide phosphoribosyltransferase, NAmPRTase, EC=2.4.2.12, Pre-B-cell colony- Other names enhancing factor 1, PBEF1, NAMPT Product category Energy metabolism and body weight regulation, Animal studies Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.125 to 8 ng/ml Limit of detection 30 pg/ml Applications Serum Storage/Shipping 2–8 °C/Wet ice

HUMAN VISFATIN (NAMPT) (INTRACELLULAR) ELISA IMMUNOASSAYS

Cat. No. RAG008R RUO Pre-B cell colony-enhancing factor, PBEF, Nicotinamide phosphoribosyltransferase, NAmPRTase, EC=2.4.2.12, Pre-B-cell colony- Other names enhancing factor 1, PBEF1, NAMPT Product category Energy metabolism and body weight regulation, Animal studies Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.063 to 16 ng/ml Limit of detection 30 pg/ml Applications cell lysate Sample requirements Storage/Shipping 2–8 °C/Wet ice

MOUSE/RAT VISFATIN (NAMPT) ELISA

Cat. No. RAG009R RUO Pre-B cell colony-enhancing factor, PBEF, Nicotinamide phosphoribosyltransferase, NAmPRTase, EC=2.4.2.12, Pre-B-cell colony- Other names enhancing factor 1, PBEF1, NAMPT Product category Energy metabolism and body weight regulation, Animal studies Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.5 to 32 ng/ml Limit of detection 50 pg/ml Applications serum Sample requirements Storage/Shipping 2–8 °C/Wet ice

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MOUSE/RAT VISFATIN (NAMPT) ELISA

Cat. No. RAG010R RUO Pre-B cell colony-enhancing factor, PBEF, Nicotinamide phosphoribosyltransferase, NAmPRTase, EC=2.4.2.12, Pre-B-cell colony- Other names enhancing factor 1, PBEF1, NAMPT Product category Energy metabolism and body weight regulation, Animal studies Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 0.5 to 32 ng/ml Limit of detection 50 pg/ml Applications cell lysate Sample requirements Storage/Shipping 2–8 °C/Wet ice

HUMAN ZINC-ALPHA-2-GLYCOPROTEIN ELISA Zinc-alpha-2-glycoprotein (ZAG) is a 41 kDa glycoprotein belonging to the major histocompatibility complex class I (MHC I) protein family. ZAG consists of single chain polypeptide that is widely distributed in body fluids and presented in various epithelia. It is also produced and secreted by mature adipocytes in both white and brown adipose tissue with autocrine effects on the reduction of adiposity in cachexia. Additionaly to cachexia, ZAG is involved in obesity, bladder and prostate cancer, frontotemporal dementia, regulation of melanin production by melanocytes etc.

Cat. No. RD191093100R RUO Other names ZA2G, ZAG, AZGP1 Product category Energy metabolism and body weight regulation, Oncology Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 3 to 100 ng/ml Limit of detection 0.673 ng/ml Applications serum, plasma Sample requirements 10 µl/well Storage/Shipping 2–8 °C/Wet ice V–Z

HUMAN ZINC TRANSPORTER 8 AUTOANTIBODY ELISA

Cat. No. RZnT8/96R RUO Other names ZnT8 Ab Product category Diabetology Assay format Sandwich ELISA, Biotin-labelled antibody Calibration range 10 to 2000 units/mL Limit of detection 1.2 units/mL Applications plasma (heparin, citrate), serum Sample requirements 25 μL Storage/Shipping 2–8 °C/Wet ice

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HUMAN ZYMOGEN GRANULE MEMBRANE PROTEIN 16 ELISA Zymogen granule membrane protein 16 (ZG16) is a 16 kDa protein first identified by immunoscreening of a rat pancreatic cDNA expression library with a polyspecific antiserum raised against purified zymogen granule membranes (ZGM). ZG16 displays sequence homology especially in the carbohydrate recognition domain to the plant lectin jacalin, which recognizes terminal galactose attached to N-acetylgalactosamine by a β1–3 linkage. According to its sequence homology with this lectin, ZG16 was considered a secretory lectin ZG16. Sequence analyses uncovered that ZG16 is highly conserved amongst mammals but also appears in many other species. Rat ZG16 was found to be highly expressed in pancreas, colon, and duodenum, where the protein was localized in the zymogen granule of pancreas. The previous reports indicated that rat ZG16 took part in the formation of zymogen granule by mediating the digested enzymes to the zymogen granule membrane in pancreatic acinar cells. Human ZG16 was shown to be highly expressed in adult liver and moderately expressed in intestine (jejunum, ileum) and colon. Moreover, ZG16 is also weakly expressed in pedunculus cerebellaris but not in other brain’s regions. Owing to the specific expression pattern in human liver, ZG16 was evaluated in hepatocellular carcinoma (HCC), a common cancer worldwide (it was found that human ZG16 was significantly down-regulated in HCC). ZG16 protein took part also in several secretions of glycoproteins (the secretion of human ZG16 would be affected when the synthesis of glycans was inhibited with inhibitor or without glucose in cell culture).

Cat. No. RD191229100R RUO Other names Zymogen granule protein 16, hZG16, Secretory lectin ZG16 , ZG16 Product category Oncology, Others Assay format Sandwich ELISA, HRP-labelled antibody Calibration range 1.5 to 30 ng/ml Limit of detection 0.101 ng/ml Applications serum, plasma Sample requirements 20 µl/well Storage/Shipping 2–8 °C/Wet ice IMMUNOASSAYS

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BATS

B ioVendor A nalytical T esting S ervice

 BioVendor provides complete assay services for the detection of selected protein markers in samples of human or animal origin.  The BioVendor Analytical Testing Service offers comprehensive sample analyses for analytes measured by our assays. BioVendor is a direct assay kit manufacturer, giving our staff a unique understanding of assay performance. Our assays are fully validated for clinical studies. We can also modify and validate our existing assays to other types of matrices (urine, breast milk, tissue biopsy extract, CSF, BALF, saliva, etc.).

SAMPLES • Detailed records of the handling of samples are maintained according to SOPs, including the following: delivery date, acknowledgement of receipt, storage conditions, number of samples, date of measurement, and evaluation of appearance. • Samples are stored at -80 °C from the time of receipt to 6 months beyond the date of the Final Report. • We require a minimum sample quantity of 0.25 ml. The transfer tube should be screw capped with an individual sample number or bar code and samples should be packed with dry ice. SERVICES

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DATA GENERATION BioVendor conducts all work confidentially, accurately, and in response to our clients’ needs and expectations. Results are communicated on a timely basis and in an easily understood format. Custom reports developed to meet our clients’ needs are available in Microsoft® Excel (including *.xls *.csv *.dbt and *.dif formats) and Microsoft® Word.

Over the course of the project, we use a single lot of the assay kit and generate and store both electronic data and printouts: 1. Measuring date, name of operator and supervisor. 2. Raw data (absorbance at 450 nm), each plate (run) will contain standards, Quality Control High, Quality Control Low all in doublet and 39 (or 40) samples in doublet determinations unless otherwise specified. Typically, any samples that read high off the standard curve will be prediluted and retested if the assay has proven linearity of sample dilution. 3. Calculated data: corresponding standards are used for standard curve construction (using four-parameter function) and calculation of analyte concentration in samples.

QUALITY ASSURANCE BioVendor’s Department of Quality Assurance ensures complete oversight of all projects. Over the course of a project, we monitor intra-assay and inter-assay performance by using Quality Control High and Quality Control Low on each plate (run). Results are presented as intra-assay and inter-assay coefficients of variation (CV) calculated according to the formula: Expected/Obtained and expressed as a %. These outputs are available in both the Analytical (Validation) and Final Report.

• Routine internal audits and inspections • Data audited for integrity and reliability • Security measures to ensure electronic data retrieval • Inspections to ensure compliance of protocols and laboratory SOPs • Access to reports is limited to authorized personnel • Use of serum based Quality Controls (High and Low) • Availability of Internal Quality Controls (IQC1, IQC2, IQC3, IQC4) in case of any need for referee measurements

REPORTING OF RESULTS 1. Analytical Report (=Validation Report) is available for each microplate and contains intra- and inter-assay CVs for Quality Controls 2. Testing Service Protocol contains the raw data (absorbance) and calculated data for Standards, Quality Controls and samples 3. Results Summary contains identifiers (sample numbers) and measured values 4. Final Report

ANALYSIS SCHEDULE The following schedule is arranged before testing.

Timeline – shipping: dd/mm/yy Timeline – analysis: dd/mm/yy – dd/mm/yy Timeline – data transfer: dd/mm/yy – dd/mm/yy Timeline – analytical report: dd/mm/yy – dd/mm/yy Disposal of samples: dd/mm/yy

PRICING The total price consists of the price of the kit plus the price of the service, 200 EUR ($250). Prices include all necessary assay reagents, sample preparation, labor, raw data generation, and final data compilation into an easy-to- interpret format. Prices may vary according to the assay performed. Additional charges may be applicable for customers that require specific validations for processes such as cross reactivity and verification of performance characteristics with samples.

Prices of the kits and more information about prices is available at www.biovendor.com.

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MULTIPLEX IMMUNOASSAYS

C ustom B io-Plex® M ultianalyte D etermination S ervice

 BioVendor provides Custom Bio-Plex® Multianalyte Determination Service using market leading multianalyte system providers such as Bio- Rad, R&D Systems, Merck Millipore and others. Save your personnel and laboratory capacities, time and money and get maximum analytical information out of minimum sample volume at a minimal expense on personnel, lab instrumentation and reagents.

 BioVendor enables you to quantitate up to 100 different analytes in a drop of sample, giving you the power to understand complex relationships among proteins in normal and disease states.

SAMPLES • Detailed records of the handling of samples are maintained according to SOPs, including the following: delivery date, acknowledgement of receipt, storage conditions, number of samples, date of measurement, and evaluation of appearance. • Samples are stored at -80°C from the time of receipt to 6 months beyond the date of the Final Report. • We require a minimum sample quantity of 0.150 ml. The transfer tube should be screw capped with an individual sample number or bar code and samples should be packed with dry ice. • Sample types ranging from serum, plasma, urine to BALF and CSF. SERVICES

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DATA GENERATION BioVendor conducts all work confidentially, accurately, and in response to our clients’ needs and expectations. Results are communicated on a timely basis and in an easily understood format. Custom reports developed to meet our clients’ needs are available in Microsoft® Excel and Microsoft® Word.

Over the course of the project, we use a single lot of the assay kit and generate and store both electronic data and printouts: 1. Raw data (MFI – median fluorescence intensity at 580 nm), each plate (run) will contain standards and Quality Control all in doublet and 39 (or 40) samples in doublet determinations unless otherwise specified. Typically, any samples that read high off the standard curve will be prediluted and retested if the assay has proven linearity of sample dilution. 2. Measuring date, name of operator and supervisor. 3. Calculated data: corresponding standards are used for standard curve construction (using five -parameter function) and calculation of analyte concentration in samples. Quality Assurance.

OUR EFFORTS ARE AIMED AT THE FOLLOWING TYPES OF APPLICATIONS: • Cytokine profiling • Diabetes marker profiling • Cancer biomarker profiling • Cell signaling pathway identification • Toxicity studies

The Bio-Plex® 200 system is a suspension array system which offers protein researchers a reliable multiplex assay solution that permits analysis of up to 100 biomolecules in a single sample.

1. Coupled Beads 2. Samples and detection Antibodies

0 0 0 10 min 40 min 40 min

12 3 1 3 1 3 1

2 2 2 28

57

99

A Bio-Plex® assay uses a selection of beads with different spectral Biotin-labeled detection antibodies are specific for secondary addresses, each coupled to antibodies against a different target. epitopes on each target.

3. Reporter 4. Assay

0 0 70 min 80 min

3 1 3 1

2 2 12 28 57 99

Fluorescently labeled streptavidin reporter binds to the biotin- In the Bio-Plex® array reader, a red classification laser and labeled detection antibodies. a green reporter laser illuminate individual beads to identify each bead�s spectral address and associated reporter signal.

206 For more information please go to www.biovendor.com SERVICES

QUALITY ASSURANCE The complete oversight of all projects is ensured by high internal standards of quality control. Over the course of a project, we monitor intra-assay and inter-assay performance by using Quality Controls on each plate (run). Results are presented as intra-assay and inter-assay coefficients of variation (CV) calculated according to the formula: Expected / Obtained and expressed as a %. These outputs are available in both the Analytical (Validation) and Final Report.

• Routine internal audits and inspections • Data audited for integrity and reliability • Security measures to ensure electronic data retrieval • Inspections to ensure compliance of protocols and laboratory SOPs • Access to reports is limited to authorized personnel • Use of serum based Quality Controls

REPORTING OF RESULTS 1. Analytical Report (=Validation Report) is available for each microplate and contains intra- and inter-assay CVs for Quality Controls 2. Testing Service Protocol contains the raw data (MFI) and calculated data for Standards, Quality Controls and samples 3. Results Summary contains identifiers (sample numbers) and measured values 4. Final Report

PRICING The total price depends on the number of selected analytes and samples. Please contact us for the price that includes all necessary assay reagents, sample preparation, labour, raw data generation, and final data compilation into an easy-to-interpret format. Additional charges may be applicable.

Prices of the kits and more information about prices is available at www.biovendor.com. SERVICES

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What you need to know at the beginning: • Available analytes are divided into groups according to the field of research • All analytes in the frame of one group can be measured at once • You can choose any combination of analytes within one group • Human, Mouse, Rat and Canine kits are available • Analytes from different groups will be measured in separate tests

How to approach designing of your multiplex assay? Consider which analytes from the following tables you would like to have measured and in what kind of species samples, the contact us via e-mail, phone, or you can order the service measurement through the assay builder on our web pages www.biovendor.com/bio-plex.

Acute Phase 1 Human Mouse Rat Diabetes Group 2 Human Mouse Rat

Ferritin ● ─ ─ FGF 19 ● ─ ─

Fibrinogen ● ─ ─ FGF 21 ● ─ ─

Procalcitonin ● ─ ─ Kidney Toxicity 1 Human Mouse Rat Canine Serum amyloid A ● ─ ─ Calbindin ● ─ ─ ─ Tissue plasminogen activator ● ─ ─ Clusterin ● ─ ● ●

Acute Phase 2 Human Mouse Rat GST-π ● ─ ─ ─

α-2-macroglobin ● ─ ─ IL-18 ● ─ ● ─

C-reactive protein (CRP) ● ─ ─ KIM-1 ● ─ ● ●

Haptoglobin ● ─ ─ MCP-1 ● ─ ● ●

Serum amyloid P ● ─ ─ NGAL ─ ─ ─ ●

Osteopontin ─ ─ ● ─ Adipokine Human Mouse Rat

Leptin ● ─ ─ Kidney Toxicity 2 Human Mouse Rat

AFABP ● ─ ─ Albumin ● ─ ─

ANGPTL-3 ● ─ ─ B2M ● ─ ●

ANGPTL-4 ● ─ ─ Calbindin ─ ─ ●

Cystatin C ● ─ ● Diabetes Group 1 Human Mouse Rat NGAL ● ─ ● C-peptide ● ─ ─ Osteopontin ● ─ ─ Ghrelin ● ● ● TFF3 ● ─ ─ GIP ● ● ─

GLP-1 ● ● ● Kidney Toxicity 3 Rat Canine

Glucagon ● ● ● Albumin ● ● Insulin ● ● ─ Pulmonary disease Human Mouse Rat Leptin ● ● ● Surfactant protein A ● ─ ─ PAI-1 ● ● ● Surfactant protein D ● ─ ─ Resistin ● ● ─ Clara Cell protein ● ─ ─ Visfatin ● ─ ─

Adiponectin ● ● ─

Adipsin ● ─ ─

208 For more information please go to www.biovendor.com SERVICES

Cancer Panel 1 Human Mouse Rat Cytokine Group 1 Human Mouse Rat

sEGFR ● ─ ─ IL-1α ─ ● ●

FGF-basic ● ─ ─ IL-1β ● ● ●

Follistatin ● ─ ─ IL-1ra ● ─ ─

G-CSF ● ─ ─ IL-2 ● ● ●

HGF ● ─ ─ IL-3 ─ ● ─

sHER-2/neu ● ─ ─ IL-4 ● ● ●

sIL-6Rα ● ─ ─ IL-5 ● ● ●

Leptin ● ─ ─ IL-6 ● ● ●

Osteopontin ● ─ ─ IL-7 ● ─ ─

PDGF-AB/BB ● ─ ─ IL-7A ─ ─ ●

PECAM-1 ● ─ ─ IL-8 ● ─ ─

Prolactin ● ─ ─ IL-9 ● ● ─

SCF ● ─ ─ IL-10 ● ● ●

sTIE-2 ● ─ ─ IL-12 (p40) ─ ● ●

sVEGFR-1 ● ─ ─ IL-12 (p70) ● ● ●

sVEGFR-2 ● ─ ─ IL-13 ● ● ●

IL-15 ● ─ ─ Cancer Panel 2 Human Mouse Rat IL-17A ● ● ● Angiopoietin-2 ● ─ ─ IL-18 ─ ─ ● sCD40L ● ─ ─ Basic FGF ● ─ ─ EGF ● ─ ─ Eotaxin ● ● ─ Endoglin ● ─ ─ EPO ─ ─ ● sFASL ● ─ ─ G-CSF ● ● ● HB-EGF ● ─ ─ GM-CSF ● ● ● IGFBP-1 ● ─ ─ GRO/KC ─ ─ ● IL-6 ● ─ ─ M-CSF ─ ─ ● IL-8 ● ─ ─ IFN-γ ● ● ● IL-18 ● ─ ─ IP-10 ● ─ ─ PAI-1 ● ─ ─ KC ─ ● ─ SERVICES PLGF ● ─ ─ MCP-1 (MCAF) ● ● ● TGF-α ● ─ ─ MIP-1α ● ● ● TNF-α ● ─ ─ MIP-1β ● ● ─ uPA ● ─ ─ MIP-2 ─ ─ ● VEGF-A ● ─ ─ MIP-3α ─ ─ ● VEGF-C ● ─ ─ PDGF-BB ● ─ ─ VEGF-D ● ─ ─ RANTES ● ● ●

TNF-α ● ● ●

VEGF ● ─ ●

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Th17 Cytokine Human Mouse Rat Cytokine Group 2 Human Mouse Rat

sCD40L ● ● ─ IL-1α ● ─ ─

IFN-γ ● ─ ─ IL-2Rα ● ─ ─

IL-1ß ● ─ ─ IL-3 ● ─ ─

IL-4 ● ─ ─ IL-12 (p40) ● ─ ─

IL-6 ● ─ ─ IL-15 ─ ● ─

IL-10 ● ─ ─ IL-16 ● ─ ─

IL-17A ● ─ ─ IL-18 ● ● ─

IL-17F ● ● ─ Basic FGF ─ ● ─

IL-21 ● ● ─ CTACK ● ─ ─

IL-22 ● ● ─ GRO-α ● ─ ─

IL-23 ● ─ ─ HGF ● ─ ─

IL-23p19 ─ ● ─ ICAM-1 ● ─ ─

IL-25 ● ● ─ IFN-α2 ● ─ ─

IL-27p28 ─ ● ─ LIF ● ● ─

IL-31 ● ● ─ MCP-3 ● ─ ─

IL-33 ● ● ─ M-CSF ● ● ─

ICAM-1 ─ ● ─ MIF ● ─ ─

MIP-3α ─ ● ─ MIG ● ● ─

TNF-α ● ─ ─ MIP-2 ─ ● ─

β-NGF ● ─ ─ Tumor growth factor Human Mouse Rat PDGF-BB ─ ● ─ TGF - beta1 ● ● ● SCF ● ─ ─ TGF - beta2 ● ● ● SCGF-β ● ─ ─ TGF - beta3 ● ● ● SDF-1α ● ─ ─

TNF-β ● ─ ─

TRAIL ● ─ ─

VCAM-1 ● ─ ─

VEGF ─ ● ─

210 For more information please go to www.biovendor.com BIOMEDICAL SPECIMEN BANK

BSB

B ioMedical S pecimen B ank

 Provides various types of biological samples along with corresponding panels of data including analytical parameters, anthropometric variables and clinical information for the diagnostic industry, assay manufacturers and researchers.

 Our expanding portfolio of panels covers both physiologic and diseased conditions.

Samples are stored at -150°C, supplied on dry ice as 0.105 ml serum, urine or other body fluid, assorted in 96 microplate-format boxes.

Below please find examples of panels we provide, as well as some examples of data related to them. For more information please go to www.biomedicalspecimenbank.com. BSB

[email protected] 211 BIOMEDICAL SPECIMEN BANK

ASSAY DEVELOPMENT AND VALIDATION PANELS

A1 Serum

• A1a Normal Healthy Individuals (sera from 48-230 men and 48-230 women – healthy blood donors) Data provided: Basic anthropometric data (race, sex, age, height, weight, BMI), basic biochemistry, blood count • A1b Matrix Effect Panel (12 healthy individuals, 6 men and 6 women, blood donors, presented as serum, EDTA plasma, citrate plasma and heparin plasma) Data provided: Basic anthropometric data (race, sex, age, height, weight, BMI), basic biochemistry • A1c Freeze-Thaw Panel (8 healthy individuals, 4 men and 4 women, blood donors, sera unthawed up to thawed and frozen 11 times) Data provided: Basic anthropometric data (race, sex, age, height, weight, BMI), basic biochemistry • A1d Temperature Stability Panel at room temperature (8 healthy individuals, 4 men and 4 women, blood donors, sera stored at room temperature for 0 to 24 hours, respectively) Data provided: Basic anthropometric data (race, sex, age, height, weight, BMI), basic biochemistry • A1e Temperature Stability Panel at 37°C (8 healthy individuals, 4 men and 4 women, blood donors, sera stored at 37°C for 0 to 24 hours, respectively) Data provided: Basic anthropometric data (race, sex, age, height, weight, BMI), basic biochemistry • A1f Temperature Stability Panel at 4°C (8 healthy individuals, 4 men and 4 women, blood donors, sera stored at room temperature for 0 to 24 days, respectively) Data provided: Basic anthropometric data (race, sex, age, height, weight, BMI), basic biochemistry • A1g Circadian Panel (8 healthy individuals, 4 men and 4 women, blood donors, sera taken every hour within 24 hours) Data provided: Basic anthropometric data (race, sex, age, height, weight, BMI), basic biochemistry • A1h Hemolytic/Lipemic/Icteric Serum Panel (3 x 32 individuals) Data provided: Basic anthropometric data (race, sex, age, height, weight, BMI), basic biochemistry

A2 Urine

• A2a Normal Healthy Individuals (urine from 48-230 men and 48-230 women – healthy blood donors) Data provided: Basic anthropometric data (race, sex, age, height, weight, BMI), basic biochemistry • A2b Freeze-Thaw Panel (8 healthy individuals, 4 men and 4 women, blood donors, urine unthawed up to thawed and frozen 11 times) Data provided: Basic anthropometric data (race, sex, age, height, weight, BMI), basic biochemistry • A2c Temperature Stability Panel at room temperature (8 healthy individuals, 4 men and 4 women, blood donors, urine stored at room temperature for 0 to 24 hours, respectively) Data provided: Basic anthropometric data (race, sex, age, height, weight, BMI), basic biochemistry • A2d Temperature Stability Panel at 37°C (8 healthy individuals, 4 men and 4 women, blood donors, urine stored at 37°C for 0 to 24 hours, respectively) Data provided: Basic anthropometric data (race, sex, age, height, weight, BMI), basic biochemistry • A2e Temperature Stability Panel at 4°C (8 healthy individuals, 4 men and 4 women, blood donors, urine stored at room temperature for 0 to 24 days, respectively) Data provided: Basic anthropometric data (race, sex, age, height, weight, BMI), basic biochemistry

A3 Seminal Plasma

A4 Cerebrospinal Fluid

A5 Synovial fluid

A6 Saliva

212 For more information please go to www.biomedicalspecimenbank.com BIOMEDICAL SPECIMEN BANK

PHYSIOLOGICAL PANELS

B1 Body Mass Index Panel (96 individuals, 4 individuals each of BMI 17-40) Data provided: Age, sex, weight, height, BMI, waist circumference, waist-to-hip ratio, basic biochemistry, blood count Data Provided on Request at extra Charge: Leptin, Soluble Leptin Receptor, Resisitin, Vaspin, Chemerin, Omentin, A-FABP, RBP-4, IL6, CRP, PAI, etc. Any additional parameter can be added as custom analysis/measurement. Please inquire with regard to availability and price.

B2 Age Panel (384 individuals of age 1-90 years, 2 males and 2 females of one age) Data provided: Age, sex, weight, height, BMI, basic biochemistry, blood count Any additional parameter can be added as custom analysis/measurement. Please inquire with regard to availability and price.

B3 Sex Panel (48 normal healthy males and 48 normal healthy females, age and BMI matched) Data provided: Age, sex, weight, height, BMI, basic biochemistry, blood count Any additional parameter can be added as custom analysis/measurement. Please inquire with regard to availability and price.

B4 Supine/Upright Panel

B5 Postprandial Panel

B6 Starvation Panel

B7 Exercise Panel

B8 Week of Pregnancy Panel

B9 Estrus/Menstrual Cycle Panel

B10 Newborn Panel

B11 Assayed Sera Panel

DISEASE STATE (PATHOLOGICAL) PANELS

C1 Energy metabolism/Metabolic Syndrome/Obesity

• C1a Obesity Panel (96-480 obese individuals) Data provided: Age, sex, weight, height, BMI, waist circumference, waist-to-hip ratio, basic biochemistry, blood count Data provided on request at extra charge: Leptin, Soluble Leptin Receptor, Adiponectin, Resistin, Vaspin, Chemerin, Omentin, A-FABP, RBP-4, IL6, CRP, PAI, etc. Any additional parameter can be added as custom analysis/measurement. Please inquire with regard to availability and price. • C1b Metabolic Syndrome Panel (96-480 individuals who meet the definition criteria of Metabolic Syndrome) Central obesity (defined as waist circumference with ethnicity-specific values) and any two of the following: • Raised triglycerides: > 150 mg/dl (1.7 mmol/l), or specific treatment for this lipid abnormality

• Reduced HDL cholesterol: < 40 mg/dl (1.03 mmol/l) in males, < 50 mg/dl (1.29 mmol/l) in females, or specific treatment for BSB this lipid abnormality • Raised blood pressure (BP): systolic BP > 130 or diastolic BP > 85 mm Hg, or treatment of previously diagnosed hypertension [email protected] 213 BIOMEDICAL SPECIMEN BANK

• Raised fasting plasma glucose (FPG): >100 mg/dl (5.6 mmol/l), or previously diagnosed type 2 diabetes • If FPG is > 5.6 mmol/l or 100 mg/dl, an oral glucose tolerance test is strongly recommended, but is not necessary to define presence of the syndrome • If BMI is > 30 kg/m², central obesity can be assumed and waist circumference does not need to be measured Data provided: Age, sex, weight, height, BMI, waist circumference, waist-to-hip ratio, basic biochemistry including all MS-related parameters, blood pressure at serum collection, blood pressure monitoring data/Holter (when available), information about comorbidities and corresponding therapies, blood count Data provided on request at extra charge: Leptin, Soluble Leptin Receptor, Adiponectin, Resistin, Vaspin, Chemerin, Omentin, A-FABP, RBP-4, IL6, CRP, PAI, Insulin, C-Peptide, HOMA-Index, HbA1C, Renin, Aldosterone, Apolipoproteins, etc. Any additional parameter can be added as custom analysis/measurement. Please inquire with regard to availability and price. • C1c Mental Anorexy (Anorexia Nervosa) (48 normal healthy males and 48 normal healthy females, age and BMI matched) Data provided: Age, sex, weight, height, BMI, basic biochemistry, blood count, information about each patient‘s clinical history including therapies, information about comorbidities and corresponding therapies, information about each patient‘s menstrual cycle. Data provided on request at extra charge: Leptin, Soluble Leptin Receptor, Adiponectin, Resistin, Vaspin, Chemerin, Omentin, A-FABP, RBP-4, IL6, CRP, PAI, etc., Hormone Profile (LH, FSF, Prolactin, Cortisol, Androstendiol, DHEAS, etc. Any additional parameter can be added as custom analysis/measurement. Please inquire with regard to availability and price. • C1d Weight Loss Panel (48-96 patients undergoing Sleeve Gastrectomy before and one week, one month, six months and a year thereafter, respectively)

C2 Diabetes

C3 Cardiovascular Disease

C4 Renal Disease

C5 Gastroenterology

C6 Neurology

C7 Pulmonary/Respiratory Disease

C8 Hepatology

C9 Cancer/Oncology

C10 Sepsis

C11 Trauma

C12 Immune Response

C13 Autoimmunity

C14 Infectious Diseases

C15 Reproduction

C16 Osteoporosis

214 For more information please go to www.biomedicalspecimenbank.com BIOMEDICAL SPECIMEN BANK

Materials (105 μl) are stored in tight Decapping can be done 2D Barcode screw-capped 2D-barcoded cryovials with automatically using a decapper or little dead volume at -150°C. Cryovials are manually using a special tool. placed in microtitre-plate format boxes for easy handling and automatic 2D bar code reading.

Materials are aliquoted by a robotic All processes creating the specimen Barcode reader error-free hands-off workstation. panels (aliquoting and sorting) are free of manual steps, thus excluding human error.

Materials are stored in ultra low freezers at Sample Management Software/ Panels are shipped on dry ice by -150°C Customized LIMS System priority door-to-door service BSB

[email protected] 215 216 INDEX

ANTI-HUMAN LIPOCALIN-TYPE PROSTAGLANDIN-D SYNTHASER------13 ANTI-HUMAN MIDKINE ------13 ANTI-HUMAN MYOSIN LIGHT CHAIN (CARDIAC) ------13 ANTIBODIES ANTI-HUMAN MYOSTATIN ------13 ANTI-HUMAN ACYLATION STIMULATING PROTEIN ------8 ANTI-HUMAN MYOSTATIN PROPEPTIDE ------13 ANTI-HUMAN ADIPOCYTE FABP ------8 ANTI-HUMAN MYOSTATIN PROPEPTIDE ------13 ANTI-HUMAN ADIPOCYTE FABP ------8 ANTI-HUMAN MYOSTATIN PROPEPTIDE ------13 ANTI-HUMAN ADIPONECTIN ------8 ANTI-HUMAN NESFATIN-1------13 ANTI-HUMAN ADIPONECTIN ------8 ANTI-HUMAN NEUROGLOBIN------13 ANTI-HUMAN ADIPONECTIN ------8 ANTI-HUMAN NEUROGLOBIN------13 ANTI-HUMAN ADIPONECTIN ------8 ANTI-HUMAN OMENTIN-1------14 ANTI-MURINE ADIPONECTIN ------8 ANTI-HUMAN OMENTIN-1------14 ANTI-PORCINE ADIPONECTIN ------8 ANTI-HUMAN OSTEOBLAST SPECIFIC FACTOR 1------14 ANTI-PORCINE ADIPONECTIN ------8 ANTI-HUMAN OSTEOBLAST SPECIFIC FACTOR 1------14 ANTI-HUMAN ADIPOPHILIN------8 ANTI-HUMAN OSTEOBLAST SPECIFIC FACTOR 2 ------14 ANTI-HUMAN ADIPOPHILIN------8 ANTI-HUMAN OSTEOBLAST SPECIFIC FACTOR 2 ------14 ANTI-HUMAN AGOUTI-RELATED PROTEIN ------8 ANTI-HUMAN OSTEOCRIN ------14 ANTI-HUMAN ALLOGRAFT INFLAMMATORY FACTOR-1------8 ANTI-HUMAN OSTEOPROTEGERIN------14 ANTI-HUMAN ANGIOPOIETIN-LIKE PROTEIN 3 ------8 ANTI-HUMAN OSTEOPROTEGERIN------14 ANTI-HUMAN ANGIOPOIETIN-LIKE PROTEIN 3 ------9 ANTI-HUMAN PEDF------14 ANTI-HUMAN ANGIOPOIETIN-LIKE PROTEIN 4 ------9 ANTI-HUMAN PEDF------14 ANTI-HUMAN ANGIOPOIETIN-LIKE PROTEIN 4 ------9 ANTI-HUMAN PROCATHEPSIN K ------14 ANTI-HUMAN ANGIOPOIETIN-LIKE PROTEIN 4 ------9 ANTI-HUMAN PROCATHEPSIN K ------14 ANTI-HUMAN ANGIOSTATIN------9 ANTI-HUMAN PROCATHEPSIN K ------14 ANTI-HUMAN APOLIPOPROTEIN D------9 ANTI-HUMAN PROSTATE-SPECIFIC GENE-1------15 ANTI-HUMAN ARGINASE-I (LIVER TYPE)------9 ANTI-HUMAN REGENERATING PROTEIN 1 alpha ------15 ANTI-HUMAN BETA-MICROSEMINOPROTEIN------9 ANTI-HUMAN RELM-beta ------15 ANTI-HUMAN BETA-MICROSEMINOPROTEIN------9 ANTI-HUMAN RESISTIN ------15 ANTI-HUMAN CARDIOTROPHIN-1------9 ANTI-HUMAN RESISTIN ------15 ANTI-HUMAN CARDIOTROPHIN-1------9 ANTI-RAT RESISTIN ------15 ANTI-HUMAN CARDIOTROPHIN-1------9 ANTI-HUMAN S100A6------15 ANTI-HUMAN CARTILAGE OLIGOMERIC MATRIX PROTEIN (COMP) ---- 9 ANTI-HUMAN S100A6------15 ANTI-HUMAN CARTILAGE OLIGOMERIC MATRIX PROTEIN (COMP) ---10 ANTI-HUMAN S100A8------15 ANTI-HUMAN CARTILAGE OLIGOMERIC MATRIX PROTEIN (COMP) ---10 ANTI-HUMAN S100A9------15 ANTI-HUMAN CATHEPSIN K ------10 ANTI-HUMAN S100A10 ------15 ANTI-HUMAN CLARA CELL PROTEIN ------10 ANTI-HUMAN S100A11------15 ANTI-HUMAN CLUSTERIN ------10 ANTI-HUMAN S100A13 ------15 ANTI-CANINE CLUSTERIN------10 ANTI-HUMAN S100G ------16 ANTI-CANINE CLUSTERIN------10 ANTI-HUMAN SECRETAGOGIN------16 ANTI-RAT CLUSTERIN ------10 ANTI-HUMAN SECRETAGOGIN------16 ANTI-HUMAN CXCL12------10 ANTI-RAT SECRETAGOGIN------16 ANTI-HUMAN CXCL12------10 ANTI-HUMAN sPLA2-IB ------16 ANTI-HUMAN CYSTATIN C ------10 ANTI-HUMAN sPLA2-IIA ------16 ANTI-HUMAN CYSTATIN C ------10 ANTI-HUMAN sPLA2-IID ------16 ANTI-HUMAN CYSTATIN C ------10 ANTI-HUMAN sPLA2-IIE ------16 ANTI-HUMAN CYSTATIN C ------10 ANTI-HUMAN sPLA2-X ------16 ANTI-CANINE CYSTATIN C------11 ANTI-HUMAN sPLA2-XII ------16 ANTI-CANINE CYSTATIN C------11 ANTI-HUMAN sRAGE------16 ANTI-MOUSE CYSTATIN C------11 ANTI-HUMAN sRANK ------16 ANTI-MOUSE CYSTATIN C------11 ANTI-HUMAN STANNIOCALCIN-1 ------16 ANTI-MOUSE CYSTATIN C------11 ANTI-HUMAN sTfR ------16 ANTI-HUMAN ENDOSTATIN ------11 ANTI-HUMAN THYROSTIMULIN BETA SUBUNIT------17 ANTI-HUMAN Ep-CAM ------11 ANTI-HUMAN THYROSTIMULIN BETA SUBUNIT------17 ANTI-HUMAN EPIDERMAL FABP------11 ANTI-HUMAN TRAP 5 ------17 ANTI-HUMAN EPIDERMAL FABP------11 ANIT-HUMAN TREFOIL FACTOR 1------17 ANTI-HUMAN FETUIN-A (AHSG)------11 ANIT-HUMAN TREFOIL FACTOR 1------17 ANTI-HUMAN FETUIN-A (AHSG)------11 ANTI-HUMAN TREFOIL FACTOR 2------17 ANTI-HUMAN FIBROBLAST GROWTH FACTOR 19------11 ANTI-HUMAN TREFOIL FACTOR 2------17 ANTI-HUMAN FIBROBLAST GROWTH FACTOR 19------11 ANTI-HUMAN TREFOIL FACTOR 3------17 ANTI-HUMAN FIBROBLAST GROWTH FACTOR 21------12 ANTI-HUMAN TREFOIL FACTOR 3------17 ANTI-HUMAN FIBROBLAST GROWTH FACTOR 21------12 ANTI-HUMAN UROMODULIN------17 ANTI-MOUSE FIBROBLAST GROWTH FACTOR 21------12 ANTI-HUMAN UROMODULIN------17 ANTI-HUMAN FIBROBLAST GROWTH FACTOR 23 ------12 ANTI-HUMAN VISININ LIKE PROTEIN 1------17 ANTI-HUMAN VIRUS HEPATITIS B PROTEIN X ------12 ANTI-HUMAN VISININ LIKE PROTEIN 1------17 ANTI-HUMAN HERSTATIN------12 ANTI-HUMAN ZINC-ALPHA-2-GLYCOPROTEIN ------17 ANTI-HUMAN HERSTATIN------12 ANTI-HUMAN ZINC-ALPHA-2-GLYCOPROTEIN ------18 ANTI-HUMAN HERSTATIN------12 ANTI-HUMAN ZYMOGEN GRANULE MEMBRANE PROTEIN 16------18 ANTI-HUMAN HERSTATIN------12 ANTI-HUMAN ZYMOGEN GRANULE MEMBRANE PROTEIN 16------18 ANTI-HUMAN HERSTATIN------12 ANTI-HUMAN INTERLEUKIN-33------12 ANTI-HUMAN INTERLEUKIN-33------12 ANTI-HUMAN LEPTIN ------12 ANTI-HUMAN LEPTIN ------12 ANTI-MOUSE LEPTIN ------12 PROTEINS ANTI-RAT LEPTIN ------12 HUMAN ADIPOCYTE FABP TAG FREE ------21 ANTI-HUMAN LEPTIN RECEPTOR ------13 HUMAN ADIPOCYTE FABP------21 ANTI-HUMAN LEPTIN RECEPTOR ------13 HUMAN ADIPONECTIN------21 ANTI-HUMAN LIPOCALIN-TYPE PROSTAGLANDIN-D SYNTHASER------13 HUMAN ADIPONECTIN------21

217 INDEX

HUMAN ADIPONECTIN TAG FREE------21 HUMAN FAM3B------34 HUMAN SERUM ADIPONECTIN------21 HUMAN FAM3C------34 HUMAN ADIPONECTIN (TRIMERIC FORM)------22 HUMAN FAM3D------35 HUMAN GLOBULAR ADIPONECTIN------22 HUMAN FATTY ACID BINDING PROTEIN 12------35 MOUSE ADIPONECTIN (TRIMERIC FORM)------22 HUMAN FETUIN-A (AHSG)------35 MOUSE ADIPONECTIN ------22 HUMAN FETUIN-B------35 PORCINE ADIPONECTIN ------22 MOUSE FIBROBLAST GROWTH FACTOR 15------35 HUMAN ADIPOPHILIN ------22 HUMAN FIBROBLAST GROWTH FACTOR 19------35 HUMAN ADROPIN------23 HUMAN FIBROBLAST GROWTH FACTOR 21------36 HUMAN AGOUTI–RELATED PROTEIN------23 HUMAN FIBROBLAST GROWTH FACTOR 21 TAG FREE------36 HUMAN ALLOGRAFT INFLAMMATORY FACTOR-1 ------23 MOUSE FIBROBLAST GROWTH FACTOR 21------36 HUMAN ALPHA-1-ACID GLYCOPROTEIN ------23 MOUSE FIBROBLAST GROWTH FACTOR 21 TAG FREE------36 HUMAN ALPHA-DYSTROGLYCAN N-TERMINAL DOMAIN------23 HUMAN FIBROBLAST GROWTH FACTOR 23 C-TERMINAL PEPTIDE----36 HUMAN ANGIOPOIETIN-LIKE PROTEIN 2------23 HUMAN FOLLISTATIN------36 HUMAN ANGIOPOIETIN-LIKE PROTEIN 3------24 HUMAN GALACTOSIDASE-BINDING SOLUBLE LECTIN 13------37 HUMAN ANGIOPOIETIN-LIKE PROTEIN 3------24 HUMAN GAMMA ENOLASE------37 HUMAN ANGIOPOIETIN-LIKE PROTEIN 4------24 HUMAN GANGLIOSIDE GM2 ACTIVATOR------37 HUMAN ANGIOPOIETIN-LIKE PROTEIN 4------24 HUMAN GASTROKINE-1------37 HUMAN ANGIOPOIETIN-LIKE PROTEIN 6------24 HUMAN GASTROKINE-2------37 HUMAN ANGIOTENSINOGEN------24 HUMAN GASTROTROPIN------37 HUMAN ANNEXIN A1------25 HUMAN GHRELIN ACYLATED (GHRELIN-28)------38 HUMAN ANNEXIN A2------25 HUMAN GLP-1/GLUCAGON-LIKE PEPTIDE-1------38 HUMAN ANNEXIN A2------25 HUMAN GLUCAGON-LIKE PEPTIDE-1 RECEPTOR ------38 HUMAN APOLIPOPROTEIN A5------25 HUMAN GP96 (TRA1)------38 HUMAN APOLIPOPROTEIN D------25 HUMAN GRANULYSIN------38 HUMAN APOLIPOPROTEIN D------25 HUMAN GROWTH DIFFERENTIATION FACTOR-3 ------38 HUMAN APOLIPOPROTEIN M------26 HUMAN GRP-78------39 HUMAN BETA-MICROSEMINOPROTEIN ------26 HUMAN HEART FABP------39 HUMAN BETATROPHIN------26 HUMAN HEAT SHOCK 10 kDa PROTEIN, MITOCHONDRIAL------39 HUMAN BILE SALT-ACTIVATED LIPASE------26 HUMAN HEAT SHOCK 70 kDa PROTEIN 1A/1B------39 HUMAN BRAIN FABP------26 VIRUS HEPATITIS B PROTEIN X------39 HUMAN CARDIOTROPHIN-1------26 HUMAN HERSTATIN TAG FREE------39 HUMAN CARTILAGE OLIGOMERIC MATRIX PROTEIN------27 HUMAN HIGH MOBILITY GROUP PROTEIN B1------40 HUMAN CARTILAGE OLIGOMERIC MATRIX PROTEIN------27 HUMAN HIV-1 PROTEASE------40 HUMAN CCL2 (MCP-1)------27 HUMAN HIV-2 PROTEASE------40 HUMAN CCL3 (MIP-1α)------27 HUMAN HSP90 CO-CHAPERONE CDC37------40 HUMAN CCL5 (RANTES) ------27 HUMAN INSULIN RECEPTOR------40 HUMAN CCL7 (MCP-3)------27 HUMAN INTERLEUKIN-6------40 HUMAN CCL7 (MCP-3) (BIOTINYLATED) ------28 HUMAN INTERLEUKIN-33------41 HUMAN CCL19 (MIP-3β) ------28 HUMAN INTESTINAL FABP ------41 HUMAN CCL27 (CTACK) ------28 HUMAN IRISIN------41 HUMAN CCL28 (MEC)------28 HUMAN KLOTHO------41 HUMAN CD5 ANTIGEN-LIKE ------28 HUMAN LACTOFERRIN------41 HUMAN CLARA CELL PROTEIN------28 HUMAN LACTOFERRIN------41 HUMAN CLAUDIN-4 ------29 HUMAN LECITHIN-CHOLESTEROL ACYLTRANSFERASE------42 HUMAN CLUSTERIN------29 HUMAN LECITHIN-CHOLESTEROL ACYLTRANSFERASE------42 HUMAN CLUSTERIN------29 HUMAN LEPTIN TAG FREE------42 CANINE CLUSTERIN------29 MOUSE LEPTIN TAG FREE------42 CANINE CLUSTERIN------29 RAT LEPTIN TAG FREE ------42 RAT CLUSTERIN------29 HUMAN SERUM LEUCINE-RICH ALPHA-2-GLYCOPROTEIN------42 HUMAN COLLECTRIN ------30 CANINE LEUCINE-RICH ALPHA-2-GLYCOPROTEIN------43 HUMAN CONNECTIVE TISSUE GROWTH FACTOR------30 HUMAN LIPOCALIN-2/NGAL------43 HUMAN CONNECTIVE TISSUE GROWTH FACTOR------30 HUMAN LIPOPROTEIN LIPASE------43 HUMAN CORNIFIN-B------30 HUMAN LIPOPROTEIN LIPASE------43 HUMAN CORTICOTROPIN-RELEASING FACTOR-BINDING ------30 HUMAN LIVER FABP------43 HUMAN CTRP1------30 HUMAN LIVER FABP TAG FREE------43 HUMAN CTRP2------31 PHOTINUS PYRALIS LUCIFERIN 4-MONOOXYGENASE------44 HUMAN CTRP3------31 HUMAN MAMMAGLOBIN A------44 HUMAN CTRP6------31 HUMAN MIDKINE------44 HUMAN CTRP7------31 HUMAN MYELIN FABP------44 HUMAN CTRP8------31 HUMAN MYOSTATIN------44 HUMAN CTRP9A ------31 HUMAN MYOSTATIN PROPEPTIDE TAG FREE------44 HUMAN CXCL8 (IL-8)------32 HUMAN NESFATIN-1------45 HUMAN CXCL12 (SDF-1α)------32 HUMAN NEUDESIN------45 HUMAN CXCL12 (SDF-1α) (BIOTINYLATED)------32 HUMAN NEURITIN------45 CANINE CYCLOPHILIN A------32 HUMAN NEUROGLOBIN TAG FREE------45 CANINE CYSTATIN C------32 HUMAN NEUROSERPIN------45 HUMAN CYSTATIN C------32 HUMAN NKG2D LIGAND 1------45 HUMAN CYSTATIN C------33 HUMAN NKG2D LIGAND 2------46 MOUSE CYSTATIN C------33 HUMAN NKG2D LIGAND 3------46 RAT CYSTATIN C------33 HUMAN OMENTIN------46 HUMAN CYSTEINE-RICH SECRETORY PROTEIN 1------33 HUMAN ONCOMODULIN-1------46 HUMAN CYTOKINE-LIKE PROTEIN 1------33 HUMAN OSTEOACTIVIN/GPNMB------46 HUMAN DECORIN------33 HUMAN OSTEOBLAST SPECIFIC FACTOR 1------46 HUMAN DIPEPTIDYL PEPTIDASE IV------34 HUMAN OSTEOBLAST SPECIFIC FACTOR 2------47 HUMAN ENPP1 PROTEIN------34 HUMAN OSTEOCRIN------47 HUMAN EPIDERMAL FABP TAG FREE------34 HUMAN OSTEOSTAT------47 HUMAN FAM3A------34 HUMAN PAP-I ------47

218 INDEX

HUMAN PARAOXONASE 1------47 HUMAN TREFOIL FACTOR 3------60 HUMAN PEDF------47 RAT TREFOIL FACTOR 3------60 HUMAN PEDF------48 HUMAN TRYPSIN-1------61 HUMAN PEPTIDASE INHIBITOR 16------48 HUMAN TUBULIN POLYMERIZATION-PROMOTING PROTEIN------61 HUMAN PEPTIDYL-PROLYL CIS-TRANS ISOMERASE F ------48 HUMAN TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 12 ----61 HUMAN PEPTIDYL-PROLYL CIS-TRANS ISOMERASE H------48 HUMAN ULBP5------61 HUMAN PEPTIDOGLYCAN RECOGNITION PROTEIN 1------48 CANINE UROMODULIN------61 HUMAN PHOSPHO1------48 FELINE UROMODULIN------61 HUMAN PLATELET GLYCOPROTEIN 4------49 HUMAN UROMODULIN------62 HUMAN PROCALCITONIN------49 PORCINE UROMODULIN------62 HUMAN PROGHRELIN------49 HUMAN VASPIN ------62 HUMAN PROGUANYLIN------49 HUMAN VISFATIN------62 HUMAN PROHIBITIN------49 HUMAN VISININ-LIKE PROTEIN 1------62 HUMAN PROLACTIN-INDUCIBLE PROTEIN------49 HUMAN WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 2------62 HUMAN PROLINE-RICH ACIDIC PROTEIN 1------50 HUMAN XYLOSYLTRANSFERASE 2------63 HUMAN PROSTAGLANDIN D SYNTHASE ------50 HUMAN ZINC-ALPHA-2-GLYCOPROTEIN------63 HUMAN PROSTATE-SPECIFIC ANTIGEN------50 HUMAN ZINC-ALPHA-2-GLYCOPROTEIN------63 HUMAN PROSTATE-SPECIFIC GENE-1 ------50 HUMAN ZYMOGEN GRANULE MEMBRANE PROTEIN 16 ------63 HUMAN PROTEIN DISULFIDE-ISOMERASE A3------50 HUMAN PROUROGUNAYLIN------50 HUMAN PYRUVATE KINASE M2------51 HUMAN REGENERATING PROTEIN 1 ALPHA------51 HUMAN REGENERATING PROTEIN 1 BETA ------51 HUMAN REGENERATING PROTEIN 4 ------51 IMMUNOASSAYS HUMAN REGUCALCIN------51 HUMAN 2 SCREEN ISLET CELL AUTOANTIBODY ELISA------67 MOUSE RELM-ALPHA------51 5α-ANDROSTANE-3α,17β-DIOL GLUCURONIDE ELISA------67 HUMAN RELM-BETA------52 8-OHDG------67 MOUSE RELM-GAMMA------52 HUMAN 8-OHdG CHECK ELISA (MULTISPECIES SPECIFICITY)------67 MOUSE RENIN RECEPTOR------52 HUMAN 8-OHdG CHECK (ULTRASENSITIVE) ELISA HUMAN RESISTIN------52 (MULTISPECIES SPECIFICITY)------67 HUMAN RESISTIN TAG FREE ------52 17α-HYDROXYPROGESTERONE ELISA------68 MOUSE RESISTIN------52 HUMAN 25-OH-VITAMIN D ELISA------68 RAT RESISTIN------53 HUMAN s90K/Mac-2BP ELISA------68 HUMAN RETINOL BINDING PROTEIN 4------53 HUMAN ACETYLCHOLINE RECEPTOR AUTOANTIBODY ELISA------69 HUMAN S100A1------53 ADIPOCYTE FATTY ACID BINDING PROTEIN (AFABP)------69 HUMAN S100A2------53 HUMAN ADIPOCYTE FABP ELISA------69 HUMAN S100A3------53 MOUSE ADIPOCYTE FABP ELISA------69 HUMAN S100A4------53 ADIPONECTIN------70 HUMAN S100A5 ------54 HUMAN ADIPONECTIN ELISA------70 HUMAN S100A6------54 HUMAN ADIPONECTIN ELISA, HIGH SENSITIVITY------70 HUMAN S100A7------54 MOUSE ADIPONECTIN ELISA------70 HUMAN S100A7A------54 PORCINE ADIPONECTIN ELISA------70 HUMAN S100A8------54 HUMAN ADIPONECTIN HMW ELISA ------71 HUMAN S100A9------54 MOUSE/RAT ADIPONECTIN HMW ELISA------71 HUMAN S100A10------55 ADMA------71 HUMAN S100A11------55 ADMA ELISA------71 HUMAN S100A12 ------55 HUMAN ADMA ELISA, HIGH SENSITIVITY------71 HUMAN S100A13------55 AGGRECAN ELISA------72 HUMAN S100A14------55 ALBUMIN (SERUM ALBUMIN)------72 HUMAN S100A16------55 BOVINE ALBUMIN ELISA------72 HUMAN S100G ------56 MOUSE ALBUMIN ELISA------72 HUMAN S100P ------56 RAT ALBUMIN ELISA------72 HUMAN SAP PROTEIN ------56 MOUSE ALBUMIN URINARY (S-TYPE) ELISA ------73 VIRUS SARS-CoV NUCLEOCAPSID PROTEIN------56 RAT ALBUMIN URINARY ASSAY------73 VIRUS SCLEROSTIN------56 RAT ALBUMIN URINARY (S-TYPE) ASSAY------73 HUMAN SECRETAGOGIN------56 ALDOSTERONE ELISA------73 RAT SECRETAGOGIN------57 HUMAN ALLOGRAFT INFLAMMATORY FACTOR 1 ELISA------74 HUMAN SECRETOGLOBIN 3A2------57 RAT ALPHA-1-ACID GLYCOPROTEIN ELISA------74 HUMAN SECRETOGLOBIN FAMILY 1D MEMBER 1------57 HUMAN ALPHA-1-ANTITRYPSIN IN STOOL ELISA------74 HUMAN SERGLYCIN------57 HUMAN ALPHA-FETOPROTEIN ELISA------75 HUMAN SEX HORMONE-BINDING GLOBULIN------57 HUMAN ALS ELISA------75 HUMAN sFRP-4------57 ANDROSTENEDIONE ELISA------75 HUMAN sPLA2-IB------58 ANGIOPOIETIN-LIKE PROTEIN 3------76 HUMAN sPLA2-IIA------58 HUMAN ANGIOPOIETIN-LIKE PROTEIN 3 ELISA------76 HUMAN sPLA2-IID------58 MOUSE/RAT ANGIOPOIETIN-LIKE PROTEIN 3 ELISA------76 HUMAN sPLA2-IIE------58 HUMAN ANGIOPOIETIN-LIKE PROTEIN 4 ELISA------76 HUMAN sPLA2-V------58 HUMAN ANGIOPOIETIN-LIKE PROTEIN 6 ELISA------77 HUMAN sPLA2-X------58 HUMAN ANGIOPOIETIN-LIKE PROTEIN 7 ELISA------77 HUMAN sPLA2-XII------59 HUMAN/RAT ANGIOTENSIN II ELISA------77 HUMAN sRAGE------59 HUMAN ANGIOTENSIN-CONVERTING ENZYME 2 ELISA------78 HUMAN sRAGE------59 ANNEXIN V------78 HUMAN STANNIOCALCIN-1------59 HUMAN ANNEXIN V ELISA------78 HUMAN STANNIOCALCIN-2------59 HUMAN ANTI-ANNEXIN V ELISA------78 HUMAN TESTIS FABP------59 MOUSE ANTI-dsDNA ELISA------79 HUMAN THYROSTIMULIN ALPHA SUBUNIT------60 HUMAN ANTI-IFN-ALPHA ELISA------79 HUMAN THYROSTIMULIN BETA SUBUNIT------60 HUMAN ANTI-IgA IgG ELISA------79 HUMAN TREFOIL FACTOR 1------60 KEYHOLE LIMPET HEMOCYANIN (KLH)------80 HUMAN TREFOIL FACTOR 2------60 RAT ANTI-KLH IgG ELISA------80

219 INDEX

RAT ANTI-KLH IgM ELISA------80 RAT CYSTATIN C ELISA------102 MOUSE ANTI-OVA-IgE ELISA------80 HUMAN CYTOCHROME c ELISA------102 MOUSE ANTI-OVA-IgG1 ELISA------80 DEHYDROEPIANDROSTERONE SULFATE ELISA------102 MOUSE ANTI-ssDNA ELISA------81 HUMAN DICKKOPF-RELATED PROTEIN 1 ELISA------103 HUMAN sAPO-1/FAS ELISA------81 DIHYDROTESTOSTERONE ELISA------103 HUMAN APOLIPOPROTEIN B-48 ELISA------81 MOUSE EOTAXIN ELISA------103 HUMAN APOLIPOPROTEIN D ELISA------82 HUMAN EPIDERMAL FABP ELISA------104 HUMAN APOLIPOPROTEIN H/BETA2-GP1 ELISA------82 HUMAN ERYTHYROPOIETIN ELISA------104 HUMAN APOLIPOPROTEIN M ELISA------82 ESTRADIOL ELISA------104 HUMAN APRIL ELISA------83 HUMAN FREE ESTRIOL ELISA------105 HUMAN AQUAPORIN-4 AUTOANTIBODY ELISA------83 ESTRONE ELISA------105 HUMAN ARGINASE LIVER TYPE ELISA------83 HUMAN sFAS LIGAND ELISA------105 HUMAN Bcl-2 ELISA------83 FERRITIN------106 BETA2-MICROGLOBULIN------84 HUMAN FERRITIN ELISA------106 HUMAN BETA2-MICROGLOBULIN ELISA------84 RAT FERRITIN ELISA------106 RAT BETA2-MICROGLOBULIN ELISA------84 HUMAN FETUIN-A (AHSG) ELISA------106 C-PEPTIDE------84 HUMAN FIBROBLAST GROWTH FACTOR-19 ELISA------107 HUMAN C-PEPTIDE ELISA------84 FIBROBLAST GROWTH FACTOR-21------107 MOUSE C-PEPTIDE (U-TYPE) ELISA------84 HUMAN FIBROBLAST GROWTH FACTOR-21 ELISA------107 RAT C-PEPTIDE (U-TYPE) ELISA------85 MOUSE/RAT FIBROBLAST GROWTH FACTOR-21 ELISA------107 C-REACTIVE PROTEIN------85 HUMAN FIBRONECTIN ELISA------108 CANINE C-REACTIVE PROTEIN ELISA, HIGH SENSITIVITY------85 HUMAN FOLLISTATIN ELISA------108 HUMAN C-REACTIVE PROTEIN ELISA------85 RAT FSH ELISA------108 HUMAN C-REACTIVE PROTEIN ELISA, HIGH SENSITIVITY------85 HUMAN GAD AUTOANTIBODY ELISA------109 MOUSE C-REACTIVE PROTEIN ELISA, HIGH SENSITIVITY------86 HUMAN GALECTIN-3 ELISA------109 RAT C-REACTIVE PROTEIN ELISA, HIGH SENSITIVITY------86 HUMAN GDF-15/MIC-1 ELISA------109 HUMAN CALCITONIN, HIGH SENSITIVITY ELISA------86 GHRELIN------110 HUMAN CARTILAGE OLIGOMERIC MATRIX PROTEIN ELISA------87 HUMAN GHRELIN ACYLATED ELISA------110 MOUSE CASPASE-1 ELISA------87 RAT GHRELIN ACYLATED ELISA------110 HUMAN CASPASE-8/FLICE ELISA------87 HUMAN GHRELIN UNACYLATED ELISA------110 HUMAN CASPASE-9 ELISA------88 RAT GHRELIN UNACYLATED ELISA------110 HUMAN CATHEPSIN L ELISA------88 HUMAN GLIAL FIBRILLARY ACIDIC PROTEIN ELISA------111 HUMAN sCD14 ELISA------88 RAT GLICENTIN ELISA------111 HUMAN sCD21 ELISA------89 HUMAN GLUCAGON ELISA (MULTISPECIES SPECIFICITY)------111 HUMAN sCD23 ELISA ------89 GLUCAGON-LIKE PEPTIDE-1------111 HUMAN sCD26 ELISA------89 HUMAN GLUCAGON-LIKE PEPTIDE-1 ELISA HUMAN sCD28 ELISA ------90 (MULTISPECIES SPECIFICITY)------112 HUMAN sCD30 ELISA------90 MOUSE/RAT GLUCAGON-LIKE PEPTIDE-1 (ACTIVE) ELISA------112 HUMAN sCD30L ELISA ------90 GLUCAGON-LIKE PEPTIDE-2 (GLP-2)------112 HUMAN sCD40 ELISA ------91 HUMAN GLUCAGON-LIKE PEPTIDE-2 ELISA------112 CD40L------91 MOUSE GLUCAGON-LIKE PEPTIDE-2 ELISA------112 HUMAN sCD40L ELISA------91 RAT GLUCAGON-LIKE PEPTIDE-2 ELISA------113 MOUSE sCD40L ELISA------91 HUMAN GLUTATHIONE PEROXIDASE 1 ELISA------113 HUMAN sCD44STD ELISA ------92 HUMAN GLUTATHIONE PEROXIDASE 1 (INTRACELLULAR) ELISA--- 113 HUMAN sCD44VAR (V5) ELISA------92 GM-CSF------113 HUMAN sCD44VAR (V6) ELISA------92 HUMAN GM-CSF ELISA------113 HUMAN sCD134 (OX40) ELISA------93 MOUSE GM-CSF ELISA------114 HUMAN sCD137/4-1BB ELISA------93 RAT GM-CSF ELISA------114 HUMAN sCD152/CTLA-4 ELISA------93 HUMAN GM-CSF RECEPTOR α CHAIN (CD116) ELISA------114 HUMAN CHEMERIN ELISA------94 GRANZYME------115 CHORIONIC GONADOTROPIN------94 HUMAN GRANZYME A ELISA------115 HUMAN CHORIONIC GONADOTROPIN ELISA------94 HUMAN GRANZYME B ELISA------115 HUMAN FREE BETA-CHORIONIC GONADOTROPIN ELISA------94 GROWTH HORMONE------115 HUMAN CHROMOGRANIN A ELISA------95 HUMAN GROWTH HORMONE ELISA------115 RAT CINC-1 ELISA------95 HUMAN GROWTH HORMONE SENSITIVE ELISA------116 HUMAN CLARA CELL PROTEIN ELISA------95 RAT GROWTH HORMONE ELISA------116 CLUSTERIN------96 RAT HEMOGLOBIN ELISA------116 CANINE CLUSTERIN ELISA------96 HUMAN sHER-2 ELISA------117 HUMAN CLUSTERIN ELISA------96 sHLA-G ELISA------117 RAT CLUSTERIN ELISA------96 HUMAN IA-2 AUTOANTIBODY ELISA------117 HUMAN CORTICOSTEROID-BINDING GLOBULIN ELISA------97 ICAM-1------118 CORTICOSTERONE------97 HUMAN sICAM-1 ELISA------118 HUMAN CORTICOSTERONE (MULTISPECIES SPECIFICITY) ELISA-----97 MONKEY sICAM-1 ELISA------118 MOUSE/RAT CORTICOSTERONE ELISA------97 HUMAN sICAM-2 ELISA------118 MOUSE/RAT CORTICOTROPIN RELEASING FACTOR ELISA, HUMAN sICAM-3 ELISA------119 SENSITIVE, EXTRACTION-FREE------98 HUMAN IFN-ALPHA ELISA------119 CORTISOL------98 IFN-GAMMA------119 CORTISOL ELISA------98 HUMAN IFN-GAMMA ELISA------119 HUMAN CORTISOL (SALIVA) ELISA------98 HUMAN IFN-GAMMA ELISA, HIGH SENSITIVITY------120 HUMAN CTRP1 ELISA ------99 MOUSE IFN-GAMMA ELISA------120 HUMAN CTRP3 ELISA------99 PIG IFN-GAMMA ELISA------120 HUMAN CTRP5 ELISA------100 RAT IFN-GAMMA ELISA------120 HUMAN CTRP9 ELISA------100 HUMAN IFN-OMEGA ELISA------121 HUMAN Cu/Zn SUPEROXIDE DISMUTASE ELISA------101 IGF-1------121 CYSTATIN C------101 HUMAN IGF-1 ELISA------121 CANINE CYSTATIN C ELISA ------101 MOUSE/RAT IGF-1 ELISA------121 HUMAN CYSTATIN C ELISA------101 HUMAN IGF-2 ELISA------121 MOUSE CYSTATIN C ELISA------102 IGFBP-1 ELISA------122

220 INDEX

HUMAN IGFBP-1 ELISA------122 MONKEY INTERLEUKIN-12 (p70) ELISA------138 HUMAN IGFBP-1 ELISA------122 MOUSE INTERLEUKIN-12 (p70) ELISA------139 IGFBP-2------122 MOUSE INTERLEUKIN-12 TOTAL (p40 + p70) ELISA------139 HUMAN IGFBP-2 ELISA------122 HUMAN INTERLEUKIN-12/INTERLEUKIN-23 p40 ELISA------139 MOUSE/RAT IGFBP-2 ELISA------123 INTERLEUKIN-13------140 IGFBP-3------123 HUMAN INTERLEUKIN-13 ELISA------140 HUMAN IGFBP-3 FUNCTIONAL ELISA------123 MOUSE INTERLEUKIN-13 ELISA------140 HUMAN IGFBP-3 TOTAL ELISA------123 HUMAN INTERLEUKIN-13 RECEPTOR SUBUNIT ALPHA-2 ELISA---- 140 MOUSE/RAT IGFBP-3 ELISA------123 HUMAN INTERLEUKIN-15 ELISA------140 HUMAN IMMUNOGLOBULIN A (SECRETORY) IN STOOL ELISA ----- 124 MOUSE INTERLEUKIN-15/INTERLEUKIN-15 RECEPTOR ELISA----- 141 IMMUNOGLOBULIN E------124 INTERLEUKIN-17------141 MOUSE IMMUNOGLOBULIN E ELISA------124 HUMAN INTERLEUKIN-17A ELISA------141 RAT IMMUNOGLOBULIN E ELISA------124 MOUSE INTERLEUKIN-17 ELISA------141 HUMAN IMMUNOGLOBULIN FREE LIGHT CHAINS ELISA------125 RAT INTERLEUKIN-17A ELISA------141 INSULIN------125 HUMAN INTERLEUKIN-17AF ELISA------142 CANINE INSULIN ELISA------125 HUMAN INTERLEUKIN-17F ELISA------142 HAMSTER INSULIN STANDARD------125 MOUSE INTERLEUKIN-17F ELISA------142 HUMAN INSULIN ELISA------125 PIG INTERLEUKIN-18 ELISA------142 HUMAN INSULIN ELISA (MULTISPECIES SPECIFICITY)------126 HUMAN INTERLEUKIN-21 ELISA------143 MOUSE INSULIN (H-TYPE) ELISA------126 INTERLEUKIN-22------143 MOUSE INSULIN (RTU) ELISA------126 HUMAN INTERLEUKIN-22 ELISA------143 MOUSE INSULIN (S-TYPE) ELISA------126 MOUSE INTERLEUKIN-22 ELISA------143 MOUSE INSULIN (TMB) ELISA------126 INTERLEUKIN-23------144 MOUSE INSULIN (U-TYPE) ELISA------127 HUMAN INTERLEUKIN-23 ELISA------144 PORCINE INSULIN ELISA------127 MOUSE INTERLEUKIN-23 ELISA------144 RAT INSULIN (H-TYPE) ELISA------127 HUMAN INTERLEUKIN-27 ELISA------144 RAT INSULIN (RTU) ELISA------127 HUMAN INTERLEUKIN-29 ELISA------145 RAT INSULIN (S-TYPE) ELISA------127 HUMAN INTERLEUKIN-31 ELISA------145 RAT INSULIN (TMB) ELISA------128 HUMAN INTERLEUKIN-33 ELISA------145 RAT INSULIN (U-E TYPE) ELISA------128 IP-10------146 INTERLEUKIN-1ALPHA (IL-1α)------128 HUMAN IP-10 ELISA------146 HUMAN INTERLEUKIN-1 ALPHA ELISA------128 MOUSE IP-10 ELISA------146 MOUSE INTERLEUKIN-1 ALPHA ELISA------128 IRISIN ELISA------146 RAT INTERLEUKIN-1 ALPHA ELISA------129 KIM-1------147 HUMAN INTERLEUKIN-1RA ELISA------129 HUMAN KIM-1 ELISA------147 INTERLEUKIN-1 BETA (IL-1β)------129 RAT KIM-1 ELISA------147 HUMAN INTERLEUKIN-1 BETA ELISA------129 HUMAN KL-6 ELISA------147 MONKEY INTERLEUKIN-1 BETA ELISA------129 HUMAN LECITHIN-CHOLESTEROL ACYLTRANSFERASE ELISA------148 MOUSE INTERLEUKIN-1 BETA ELISA------130 LEPTIN------148 RAT INTERLEUKIN-1 BETA ELISA------130 HUMAN LEPTIN ELISA------148 INTERLEUKIN-2------130 MOUSE/RAT LEPTIN ELISA------148 HUMAN INTERLEUKIN-2 ELISA------130 HUMAN LEPTIN RECEPTOR ELISA------149 HUMAN INTERLEUKIN-2 ELISA, HIGH SENSITIVITY------130 LUTEINIZING HORMONE (LH)------149 MONKEY INTERLEUKIN-2 ELISA------131 HUMAN LH ELISA------149 MOUSE INTERLEUKIN-2 ELISA------131 RAT LH ELISA (S-TYPE) ELISA, HIGH SENSITIVITY------150 RAT INTERLEUKIN-2 ELISA------131 HUMAN LIF ELISA------150 HUMAN sINTERLEUKIN-2 RECEPTOR ELISA------131 HUMAN LIPOCALIN-2/NGAL ELISA------150 INTERLEUKIN-4------132 HUMAN MATRIX METALLOPROTEINASE-3 ELISA------151 HUMAN INTERLEUKIN-4 ELISA------132 HUMAN MATRIX METALLOPROTEINASE-9 ELISA------151 HUMAN INTERLEUKIN-4 ELISA, HIGH SENSITIVITY------132 HUMAN MATRIX METALLOPROTEINASE-13 ELISA------151 MOUSE INTERLEUKIN-4 ELISA------132 HUMAN MICA ELISA------152 RAT INTERLEUKIN-4 ELISA------132 HUMAN MIDKINE ELISA------152 HUMAN INTERLEUKIN-4 RECEPTOR (CD124) ELISA------133 MONOCYTE CHEMOTACTIC PROTEIN-1------152 INTERLEUKIN-5------133 HUMAN MONOCYTE CHEMOTACTIC PROTEIN-1 ELISA------152 HUMAN INTERLEUKIN-5 ELISA------133 MOUSE MONOCYTE CHEMOTACTIC PROTEIN-1 ELISA------153 MOUSE INTERLEUKIN-5 ELISA------133 HUMAN MPO ELISA------153 INTERLEUKIN-6------134 HUMAN MxA PROTEIN ELISA------153 HUMAN INTERLEUKIN-6 ELISA------134 HUMAN NESFATIN-1 ELISA------153 HUMAN INTERLEUKIN-6 ELISA, HIGH SENSITIVITY------134 HUMAN/RAT NO SYNTHASE I ELISA------154 MONKEY INTERLEUKIN-6 ELISA------134 OBESTATIN------154 MOUSE INTERLEUKIN-6 ELISA------134 HUMAN OBESTATIN ELISA------154 RAT INTERLEUKIN-6 ELISA------135 MOUSE/RAT OBESTATIN ELISA------154 HUMAN INTERLEUKIN-6 RECEPTOR BETA (CD130) ELISA------135 HUMAN OMENTIN-1 ELISA------155 HUMAN sINTERLEUKIN-6 RECEPTOR ELISA------135 HUMAN OSTEOACTIVIN ELISA------155 HUMAN INTERLEUKIN-7 ELISA------135 HUMAN OSTEOCALCIN ELISA------155 INTERLEUKIN-8------136 HUMAN OSTEOPROTEGERIN ELISA------156 HUMAN INTERLEUKIN-8/NAP-1 ELISA------136 HUMAN p53 ELISA------156 MONKEY INTERLEUKIN-8 ELISA------136 HUMAN PAI-1 ELISA------156 HUMAN INTERLEUKIN-9 ELISA------136 HUMAN PANCTREATIC-DERIVED FACTOR ELISA------157 INTERLEUKIN-10------137 HUMAN PARATHYROID HORMONE ELISA------157 HUMAN INTERLEUKIN-10 ELISA------137 PECAM-1------158 HUMAN INTERLEUKIN-10 ELISA, HIGH SENSITIVITY------137 HUMAN sPECAM-1 ELISA------158 MONKEY INTERLEUKIN-10 ELISA------137 MONKEY sPECAM-1 ELISA------158 MOUSE INTERLEUKIN-10 ELISA------137 HUMAN PEDF ELISA------158 RAT INTERLEUKIN-10 ELISA------138 HUMAN PENTRAXIN 3 ELISA------159 INTERLEUKIN-12------138 PEPSINOGEN------159 HUMAN INTERLEUKIN-12 (p70) ELISA------138 HUMAN PEPSINOGEN I ELISA------159 HUMAN INTERLEUKIN-12 ELISA, HIGH SENSITIVITY------138 HUMAN PEPSINOGEN II ELISA------159

221 INDEX

HUMAN PERFORIN ELISA------160 TGF-BETA1------181 PERIOSTIN------160 HUMAN TGF-BETA1 ELISA------181 HUMAN PERIOSTIN ELISA------160 MOUSE TGF-BETA1 ELISA------181 MOUSE PERIOSTIN ELISA------160 RAT TGF-BETA1 ELISA------182 PEROXIREDOXIN------161 HUMAN TGF-BETA2 ELISA------182 HUMAN PEROXIREDOXIN 1 ELISA------161 HUMAN THIOREDOXIN 1 ELISA------182 HUMAN PEROXIREDOXIN 3 ELISA------161 HUMAN THIOREDOXIN REDUCTASE 1 ELISA------183 HUMAN PHOSPHORYLATED NEUROFILAMENT H ELISA------161 HUMAN THROMBOMODULIN (CD141) ELISA------183 HUMAN PLACENTAL LACTOGEN ELISA------162 THYROID STIMULATING HORMONE------183 HUMAN PMN ELASTASE ELISA------162 HUMAN THYROID STIMULATING HORMONE ELISA------183 PREGNENOLONE ELISA------162 RAT THYROID STIMULATING HORMONE ELISA------184 HUMAN PROCALCITONIN ELISA------163 THYROXINE------184 PROGESTERONE------163 HUMAN FREE THYROXINE ELISA------184 PROGESTERONE ELISA------163 HUMAN THYROXINE TOTAL ELISA------184 MOUSE/RAT PROGESTERONE ELISA------163 HUMAN TIE-2 ELISA------184 PROGRANULIN------164 HUMAN TIMP-1 ELISA------185 HUMAN PROGRANULIN ELISA------164 TNF-ALPHA------185 MOUSE PROGRANULIN ELISA------164 HUMAN TNF-ALPHA ELISA------185 RAT PROGRANULIN ELISA------164 HUMAN TNF-ALPHA TOTAL ELISA------185 HUMAN PROGUANYLIN ELISA------165 MONKEY TNF-ALPHA ELISA------185 HUMAN PROINSULIN INTACT ELISA------165 MOUSE TNF-ALPHA ELISA------186 PROLACTIN------165 RAT TNF-ALPHA ELISA------186 HUMAN PROLACTIN ELISA------165 HUMAN TNF-BETA ELISA------186 RAT PROLACTIN ELISA------166 TNF-R------187 HUMAN PRORENIN ELISA ------166 HUMAN sTNF-R (60 kDA) ELISA------187 HUMAN PROSTAGLANDIN D SYNTHASE (LIPOCALIN-TYPE) ELISA-----166 HUMAN sTNF-R (80kDA) ELISA------187 HUMAN PROSTATE SECRETORY PROTEIN 94 ELISA------167 MONKEY sTNF-R I ELISA------187 HUMAN PROUROGUANYLIN ELISA------167 HUMAN TRAIL ELISA------188 HUMAN sPSGL-1 ELISA------167 TRAIL RECEPTOR------188 PEPTIDE YY (PYY)------168 HUMAN TRAIL RECEPTOR 1 (CD261) ELISA------188 HUMAN PYY ELISA------168 HUMAN TRAIL RECEPTOR 2 (CD262) ELISA------188 RAT PYY ELISA------168 HUMAN TRAIL RECEPTOR 3 (CD263) ELISA------188 RAT QUALITY CONTROL SET (CORTICOSTERONE, PROLACTIN, HUMAN TRAIL RECEPTOR 4 (CD264) ELISA------189 TESTOSTERONE, TSH)------168 RAT TRANSFERRIN ELISA------189 HUMAN sRAGE ELISA------168 HUMAN TRAP 5 ASSAY------189 HUMAN sRANKL (TOTAL) ELISA (OSTEOPROTEGERIN LIGAND)----- 169 HUMAN TREFOIL FACTOR 1 ELISA------189 RBP4------169 HUMAN TREFOIL FACTOR 2 ELISA------190 HUMAN RBP4 ELISA------169 HUMAN TREFOIL FACTOR 3 ELISA------190 MOUSE/RAT RBP4 ELISA------169 TRIIODOTHYRONINE------190 HUMAN RENIN ELISA------170 HUMAN FREE TRIIODOTHYRONINE ELISA------190 RESISTIN------170 HUMAN TRIIODOTHYRONINE TOTAL ELISA------191 HUMAN RESISTIN ELISA------170 HUMAN TROPONIN I ELISA------191 MOUSE RESISTIN ELISA------170 TSH RECEPTOR AUTOANTIBODY------191 RAT RESISTIN ELISA------171 HUMAN TSH RECEPTOR AUTOANTIBODY ELISA 2. GENERATION---- 191 RHEUMATOID FACTOR------171 HUMAN TSH RECEPTOR AUTOANTIBODY ELISA 3. GENERATION---- 192 MOUSE IgG RHEUMATOID FACTOR ELISA------171 UROCORTIN------192 MOUSE IgM RHEUMATOID FACTOR ELISA------171 MOUSE UROCORTIN 2 ELISA------192 HUMAN S100A5 ELISA------171 MOUSE/RAT UROCORTIN 3 ELISA------192 HUMAN S100A6 ELISA (MULTISPECIES SPECIFICITY)------172 HUMAN UROMODULIN ELISA------192 HUMAN S100A11 ELISA (MULTISPECIES SPECIFICITY)------172 HUMAN sVAP-1 ELISA------193 HUMAN S100A12 ELISA------173 HUMAN VASPIN ELISA------193 HUMAN S100B ELISA------173 HUMAN sVCAM-1 ELISA------193 HUMAN S100G ELISA------174 VE-CADHERIN------194 HUMAN SDMA ELISA------174 HUMAN sVE-CADHERIN ELISA------194 sE-SELECTIN------174 MONKEY sVE-CADHERIN ELISA------194 HUMAN sE-SELECTIN ELISA------174 VEGF------194 MONKEY sE-SELECTIN ELISA------175 HUMAN VEGF-A ELISA------194 HUMAN sL-SELECTIN ELISA------175 MOUSE VEGF-A ELISA------195 P-SELECTIN------176 HUMAN VEGF-C ELISA------195 HUMAN sP-SELECTIN ELISA------176 RAT VEGF-C ELISA------195 MONKEY sP-SELECTIN ELISA ------176 HUMAN sVEGF-R1/FLT-1 ELISA------195 HUMAN SECRETAGOGIN ELISA------176 HUMAN VEGF-R2/KDR ELISA------196 HUMAN SEX HORMONE BINDING GLOBULIN ELISA------177 HUMAN VEGF-R3/FLT-4 ELISA------196 HUMAN SPERM-ANTIBODY ELISA------177 HUMAN VILIP-1 ELISA------196 HUMAN STEM CELL FACTOR RECEPTOR (CD117) ELISA------177 VISFATIN------197 SUPEROXIDE DISMUTASE------178 HUMAN VISFATIN (NAMPT) ELISA------197 HUMAN SUPEROXIDE DISMUTASE 1 ELISA------178 HUMAN VISFATIN (NAMPT) (INTRACELLULAR) ELISA------197 HUMAN SUPEROXIDE DISMUTASE 2 ELISA------178 MOUSE/RAT VISFATIN (NAMPT) ELISA------197 HUMAN SUPEROXIDE DISMUTASE 3 ELISA------178 MOUSE/RAT VISFATIN (NAMPT) ELISA------198 HUMAN SURFACTANT PROTEIN A ELISA------179 HUMAN ZINC-ALPHA-2-GLYCOPROTEIN ELISA------198 HUMAN SURFACTANT PROTEIN D ELISA------179 HUMAN ZINC TRANSPORTER 8 AUTOANTIBODY ELISA------198 HUMAN SYNDECAN-1 (CD138) ELISA------179 HUMAN ZYMOGEN GRANULE MEMBRANE PROTEIN 16 ELISA------199 HUMAN t-PA ELISA------180 TESTOSTERONE------180 TESTOSTERONE ELISA------180 HUMAN FREE TESTOSTERONE ELISA------180 MOUSE/RAT TESTOSTERONE ELISA------180 HUMAN sTfR ELISA------181

222

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