RESEARCH REPORT 2OO9-2O1O DIVISION OF HEALTH SCIENCES research report 2OO9-2O1O DIVISION OF HEALTH SCIENCES

Cover photo: Divisional winners of some of New Zealand’s most prestigious science awards in 2009 and 2010. From left to right: Professor Frank Griffin, Department of Microbiology and Immunology, 2010 Pickering Medal, Royal Society of New Zealand, Professor Warren Tate, Department of Biochemistry, 2010 Rutherford Medal, Royal Society of New Zealand, Professor Allan Herbison, Department of Physiology, 2009 Liley Medal, HRC. Professor Richie Poulton, Dunedin Multidisciplinary Health and Development Research Unit, 2010 Dame Joan Metge Medal, Royal Society of New Zealand, Absent: Professor Stephen Robertson, Department of Women’s and Children’s Health. 2010 Liley Medal, HRC.

Division of HEALTH SCIENCES 1 FROM THE PRO-VICE-CHANCELLOR

Tënä koutou kätoa. It is a great pleasure to present this report of the research activities of the Division of Health Sciences at the University of Otago for 2009-2010. The Division has an enviable reputation for research excellence and innovation and the achievements reported here reflect this. Our research helps to save lives and reduce suffering, and addresses health inequalities in New Zealand and around the world.

The Division has had another two very successful years, as measured by the award of competitive research grants, by publications in highly esteemed journals, and by awards for distinction in research. Our researchers secured over $136 million in external research grants in 2009 and 2010 – a considerable achievement in what has become an increasingly competitive funding environment. The number of research outputs has continued to increase annually with many articles appearing in the world’s most prestigious journals.

The Division is immensely proud of the number of prestigious national science awards bestowed upon its staff in recent times. In 2010, Professor Warren Tate from the Department of Biochemistry was awarded the country’s most prestigious science and technology honour, the Royal Society of New Zealand’s Rutherford Medal. Our researchers were also honoured with the Royal Society’s Pickering and Dame Joan Metge medals in 2010, as well as the Health Research Council’s Liley Medal in both 2009 and 2010. In 2010, the University awarded its own Distinguished Research Medal to Professor David Fergusson, who heads the Christchurch Health and Development Study.

The Division’s success can also be gauged by the increasing number of students attracted into its postgraduate programs. Especially pleasing is the marked increase in PhD enrolments in recent years. This trend not only reflects the high quality of the postgraduate programs we offer but also the excellent international reputations of our clinicians and academics, many of which are world leaders in their respective fields. As a Division, we have particular expertise in the fields of cancer genetics, mental health, neuroscience, infectious diseases, public health, Mäori health, cardiovascular disease, the pharmaceutical sciences, rehabilitation, diabetes and obesity, asthma, reproductive and structural biology, and oral health.

We also host a number of world-renowned research groups and centres including: the Centre for Neuroendocrinology, the Cardioendocrine Research Centre, the Cancer Genetics Laboratory, the Injury Prevention Research Unit, He Kainga Oranga/ the Housing and Health Research Programme, the Centre for International Health, the Webster Centre for Infectious Diseases, and the Dunedin Multidisciplinary Health and Development Research Unit. The innovative research undertaken by these groups and others underpins many advances in health policy and practice and the understanding of health and disease in New Zealand and beyond.

The depth and breadth of research expertise in the Division means that research informs our teaching across all aspects of health professional training. Our students are taught by academics and clinicians who are at the forefront of new knowledge, and who are closely integrated into the health workforce. A number of our researchers have successfully moved their research into commercial ventures and others have positive interactions with existing New Zealand businesses. In this manner, we believe that we are laying the foundations for the next generation of health research leaders in New Zealand.

I would like to thank all in the Division of Health Sciences for their valuable contributions to what has been an exciting period of growth and achievement. To those of you from outside of the Division reading this, I hope you find much of interest within these pages and I encourage you to contact us if you would like to know more.

Professor Peter Crampton Pro-Vice-Chancellor Division of Health Sciences University of Otago

2 RESEARCH REPORT 2009/2010 CONTENTS

FROM THE PRO-VICE CHANCELLOR 2 EXECUTIVE SUMMARY 5 NOTES ON HOW THESE DATA ARE PRESENTED 6 THE DIVISION AT A GLANCE 7 RESEARCH HIGHLIGHTS 2009-2010 9 COMMERCIALISATION 16 RESEARCH THEMES AND CENTRES 18 MÄORI HEALTH RESEARCH 26 SCHOOLS AND DEPARTMENTS 28 FACULTY OF DENTISTRY 28 Department of Oral Diagnostic and Surgical Sciences 28 Department of Oral Rehabilitation 30 Department of Oral Sciences 31 FACULTY OF MEDICINE 33 OTAGO SCHOOL OF MEDICAL SCIENCES 33 Department of Anatomy 33 Department of Biochemistry 37 Department of Microbiology and Immunology 41 Department of Pharmacology and Toxicology 44 Department of Physiology 46 DUNEDIN SCHOOL OF MEDICINE 50 Department of General Practice 50 Department of Medical and Surgical Sciences 51 Anaesthesia and Intensive Care 51 Bioethics 52 Medicine 53 Ophthalmology 55 Orthopaedic Surgery 55 Surgery 57 Department of Pathology 59 Department of Preventive and Social Medicine 61 Department of Psychological Medicine 64 Department of Women’s and Children’s Health 65 UNIVERSITY OF OTAGO, CHRISTCHURCH 67 Department of Anaesthesia 67 Department of Medicine 68 Department of Obstetrics and Gynaecology 71 Department of Orthopaedic Surgery and Musculoskeletal Medicine. 72 Department of Paediatrics 74 Department of Pathology 75 Department of Psychological Medicine 77 Department of Public Health and General Practice 79 Department of Radiology 80 Department of Surgery 81 Centre for Postgraduate Nursing Studies 82 UNIVERSITY OF OTAGO, WELLINGTON 84 Department of Medicine 84 Department of Obstetrics and Gynaecology 86 Department of Paediatrics and Child Health 86 Department of Pathology and Molecular Medicine 87 Department of Primary Health Care and General Practice 89 Department of Psychological Medicine 91 Department of Public Health 92 Department of Radiation Therapy 95 Department of Surgery and Anaesthesia 96

Division of HEALTH SCIENCES 3 SCHOOL OF PHARMACY 98 SCHOOL OF PHYSIOTHERAPY 100 COLLABORATIONS WITH EXTERNAL ORGANISATIONS 102 RESEARCH SUPPORT SERVICES 104 RESEARCH AND ENTERPRISE OFFICE 105 APPENDIX 1: PUBLICATIONS BY DEPARTMENT FOR 2009 – 2010 108 APPENDIX 2: DIVISIONAL STRUCTURE 272

Professor Barry Taylor is investigating the links between sleep patterns in infancy and obesity in childhood and adulthood.

4 RESEARCH REPORT 2009/2010 EXECUTIVE SUMMARY

• The Division of Health Sciences is a research intensive Division with the highest overall annual research income within the University.

• The Division incorporates three campuses (Dunedin, Christchurch and Wellington) and comprises the following Schools and Faculties:

Faculty of Dentistry Faculty of Medicine Otago School of Medical Sciences Dunedin School of Medicine University of Otago, Christchurch University of Otago, Wellington School of Pharmacy School of Physiotherapy

A chart showing the organisational structure of the Division is provided as Appendix 2.

• The University of Otago has established 14 Research Themes and 15 Research Centres for which the University is pre- eminent and to which it gives particular recognition and support. Researchers within the Division of Health Sciences are leaders of 9 of the Research Themes and 9 of the Research Centres.

• All Schools and Faculties have a strong research focus as evidenced by their successes in securing external income, their increasing numbers of postgraduate students, their high quality research outputs, and the many and varied honours and scholarships awarded to their staff and students.

• The Division strongly encourages and supports the dissemination and commercialisation of research results. Commercialisation activities include contract research, patents and licensing, and spin out companies.

• The Division has many diverse and valuable collaborations and affiliations with organisations external to the University of Otago. National and international connectivity and their associated benefits (e.g. co-funding opportunities, access to equipment, technologies and expertise) are viewed as crucial aspects of the Division’s research endeavours.

• The Division boasts extensive research support services including state-of-the-art research facilities and equipment, training opportunities, and staff expertise.

• The Division operates a Research Committee which is responsible for the dissemination of fellowships and funding as well as having a mentoring role for researchers. Research in the Division is further supported by the University’s Research and Enterprise Office which is the point of liaison between researchers and funding bodies.

Division of HEALTH SCIENCES 5 NOTES ON HOW THESE DATA ARE PRESENTED

This report contains information on the research activities of the Division of Health Sciences at the University of Otago, for the period 2009-2010.

The data contained within the report have been sourced from the University of Otago’s Research and Enterprise Database, from departmental websites, and from individual departments themselves. Every attempt has been made to ensure that this report is as complete and as accurate as possible, but given the diversity of activities and interests within the Division, there may be omissions or inaccuracies for which we apologise.

Things to note: • Research grants and contracts have been attributed to the home department of each principal investigator. Where there were multiple principal investigators on a given grant or contract it is acknowledged that this will duplicate the listing of a small number of grants in this report.

• In a number of cases grants/contracts straddled departments and it is unfortunate that this report is unable to give credit to co-investigators who, while not listed here, did nevertheless contribute to securing research funding.

• This report lists details of external grants that were newly approved in 2009 and 2010. A significant number of grants approved prior to 2009 were also active throughout some, or all, of this period. Specific details of these grants are not included in this report. Further information about grants approved prior to 2009 is available in the Division of Health Sciences Research Reports 2002-06 and 2007-08. http://healthsci.otago.ac.nz/research/reports.html

• Publications have been listed under the department of each author and co-author. This means that for these purposes specific publications may be listed more than once.

Other sources of information that may be of assistance to those interested in research within the Division of Health Sciences include:

The Division of Health Sciences research website: http://healthsci.otago.ac.nz/research/index.html

Research and Enterprise Office, University of Otago: www.otago.ac.nz/research/index.html

Research Office, University of Otago, Christchurch: www.otago.ac.nz/christchurch/research/researchoffice/

Research Office, University of Otago, Wellington: www.uow.otago.ac.nz/Research/office.html

Research Office, Dunedin School of Medicine http://dnmeds.otago.ac.nz/research

6 RESEARCH REPORT 2009/2010 THE DIVISION AT A GLANCE

External Research Income in $Million

Sources of External Research Grant Income Awarded 2009/2010

Research Outputs

2006 2007 2008 2009 2010

Journal Articles 1,122 1,278 1,362 1,348 1,591 All Publications 1985 1794 2,089 2,312 2,746

Division of HEALTH SCIENCES 7 University of Otago Scholarships Awarded

2006 2007 2008 2009 2010

PhD Scholarship 27 51 66 65 90* Masters Award 10 16 10 13 15

*The process for allocating scholarships changed in 2009 resulting in an unusually high number of scholarships being allocated in 2010. This anomaly will be rectified for 2011 onwards.

Staff and Student Information

2009 2010

Equivalent Full-time Students Total 5,293 5,595 Undergraduate 4,139 4,343 Postgraduate 1,154 1,252 PhD 409 430 Masters (Research) 145 156

Full-time Equivalent Staff Academic and Research Only Staff 773 799 General Staff 656 690 Total Staff 1,429 1,489 Staff Head Count 1,815 1,899

Headcount of PhD and Masters (by Research*) Students

*Masters by Research includes only Masters degrees where students undertake a significant research project and write a research thesis

8 RESEARCH REPORT 2009/2010 RESEARCH HIGHLIGHTS 2009-2010

Research Performance Indicators

~ External Research Income: The Division was awarded approximately $68 million per annum in 2009 and 2010.

~ Research Outputs: Our researchers published extensively with 2,312 research outputs in 2009 and 2,746 in 2010.

~ The University of Otago was placed first in the Nature Asia-Pacific publishing rankings for New Zealand institutions in 2010. Five of the nine papers published in the Nature journals were authored by researchers from this Division.

~ Health Research Council Funding Success: The University of Otago received more Health Research Council of New Zealand funding than any other institution in both 2009 and 2010. Divisional researchers received approximately 35% of the total funds allocated in the 2009 round and 40% in the 2010 round. The University of Otago received funding for three new Programmes in 2009 and two in 2010, all of which were awarded to researchers within the Division.

~ Marsden Funding Success: Once again the University of Otago was awarded the greatest percentage of the total national Marsden pool in both 2009 and 2010.

~ Foundation for Research Science and Technology. In 2009, the Division received renewed funding for two of its New Economy Research Fund programmes as well as securing a new project through the Antarctica portfolio.

~ Professorial Appointments: Ten professors were either newly appointed or promoted within the Division in 2009, and eleven in 2010.

Division of HEALTH SCIENCES 9 Research Outcomes

~ Warmer homes make healthier people Research on the links between cold, damp housing and poor health outcomes carried out by the He Kainga Oranga, Housing and Health Research Programme (University of Otago, Wellington) resulted in the inclusion of new targets in the 2007 New Zealand Energy Efficiency and Conservation Strategy. These targets include warm, dry homes, reducing energy costs, improving indoor air quality and reducing asthma by providing subsidies for the installation of insulation and heating for poorer households. In 2009, a government funded programme aiming to retrofit insulation into 188,500 older New Zealand homes commenced.

Professor Philippa Howden-Chapman is the Director of the He Kainga Oranga/Housing and Health Research Programme at the University of Otago, Wellington.

~ Lifecourse research Researchers from the two world leading longitudinal studies based in the Division, the Dunedin Multidisciplinary Health and Development Research Unit (DSM) and the Christchurch Health and Development Study (UOC) have guided policy development in various government departments. Examples include the development of both the New Zealand Suicide Prevention Strategy 2006–2016, and the Inter-Agency Plan for Conduct Disorder/Severe Antisocial Behaviour 2007-2012.

~ Drugs to combat HIV Professor Warren Tate and Dr Tony Cardno (Biochemistry, OSMS) have developed a drug-discovery screening assay to investigate a previously unexploited weakness in HIV biology. In partnership with the Walter and Eliza Hall Institute (WEHI) in Melbourne, they have been granted funding from the HRC to use the assay to screen for new HIV drug candidates, using the WEHI’s High Throughput Screening Facility. This may lead to potential new drugs to combat HIV-1 in patients.

~ Kidney research Two world first studies into kidney health and disease have been undertaken in the Division. Dr Alex McLellan (Department of Microbiology and Immunology, OSMS) and colleagues have developed a simple urine test to detect kidney transplant rejection. Detecting transplant rejection early on allows treatment with immunosuppressant drugs to prevent transplant loss. Professor Zoltan Endre from the Department of Medicine, UOC is a lead investigator on a study that has developed a blood test capable of detecting life threatening kidney injuries earlier and more reliably than currently available tests, once again allowing earlier treatment intervention. Further work is required before the tests can be introduced into clinical practice.

10 RESEARCH REPORT 2009/2010 Dr Alex McLellan from the Department of Microbiology and Immunology has developed a urine test to detect kidney transplant rejection.

~ Stroke recovery Dr Andrew Clarkson from the Department of Anatomy and co-researchers have developed a drug therapy which may help stroke patients regain lost movement in their arms and legs. The drug was administered to mice via a slow release pump over a six week period. Results showed a 50% gain in motor function in comparison to only a 10-15% increase with current therapy strategies. Further research and trials are needed to determine the full potential of the drug as well as its side-effects. Full findings were published in the prestigious journal Nature1

~ Breath testing for tuberculosis Professor Steve Chambers (Pathology, UOC) and Dr Mona Syhre have continued their work investigating a breath test for the diagnosis of tuberculosis. Professor Philip Hill (Preventive and Social Medicine, DSM) has joined the expert team to support clinical field work in Bundung, Indonesia. This project shows significant potential to advance the global fight against tuberculosis.

~ Control of fertility Investigators from the Centre for Neuroendocrinology have determined the way in which gonadotropin-releasing hormone neurons located in the brain act in unison to send out pulses of a hormone responsible for the cascade of events leading to ovulation and related processes2. The mode of communication of these cells had previously been unknown. The findings may aid the development of new therapies for some forms of infertility and could lead to new contraceptives.

~ Diabetes management Results from the Lifestyle Over and Above Drugs in Diabetes (LOADD) study carried out at the Edgar Centre for Diabetes Research may have major implications for diabetes management. The study has revealed that the provision of intensive dietary advice resulted in improved glycaemic control and weight loss in Type 2 diabetes patients. The ultimate aim of the research is to develop a programme of lifestyle interventions which could be put in place to assist with the management of diabetes in New Zealand.

1 Clarkson AN et al. (2010). Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke. Nature 468(7321): 305-9. 2 Campbell RE, Gaidamaka G, Han SK, Herbison AE. (2009). Dendro-dendritic bundling and shared synapses between gonadotropin-releasing hormone neurons. Proceedings of the National Academy of Sciences USA, 106: 10835–40.

Division of HEALTH SCIENCES 11 Professor Julian Crane (centre) with colleagues Dr Kristin Wickens and Robert Siebers of the Wellington Asthma Research Group, are focusing on the better management and underlying environmental causes of asthma and allergic diseases. ~ Asthma prevention It is well-known that synthetic bedding is associated with more asthma symptoms than feather bedding. One possible explanation for this has been offered by the Wellington Asthma Research Group based at the University of Otago, Wellington. The group has reported that synthetic bedding contains higher levels of fungal cell products than feather bedding in New Zealand homes3, providing further support for the promotion of feather bedding for prevention of asthma symptoms in known sufferers.

~ Infective endocarditis An international study led by Professor David Murdoch of the University of Otago, Christchurch is the largest ever carried out on infective endocarditis, and has shed new light on the presentation, etiology and outcome of the disease4. Findings are likely to lead to a revision of the way in which the disease is treated, with results showing that acute treatment measures such as early surgery are associated with a decreased mortality rate.

~ Divisional Research Forum The Division runs an annual Research Forum to showcase the cutting edge research being undertaken within its Schools. In 2009, the theme was ‘The Human Hive: Otago Researchers Working for a Healthy New Zealand’ and in 2010 it was ‘Pathways from Discovery to Delivery’.

Awards and Accolades

~ Professor Warren Tate from the Department of Biochemistry was awarded New Zealand’s premier science and technology honour, the 2010 Rutherford Medal from the Royal Society of New Zealand.

~ In 2010, Professor Frank Griffin from the Department of Microbiology and Immunology received the Royal Society of New Zealand’s Pickering Medal. This medal recognises excellence and innovation in the practical application of technology.

~ Professor Richie Poulton from the Dunedin Multidisciplinary Health and Development Research Unit was awarded the 2010 Dame Joan Metge Medal from the Royal Society of New Zealand. This award is given for excellence in social science research and in particular recognises those who have contributed to building beneficial relationships with research participants.

3 Heyes J, Siebers R, Parkes A, Pierse N, Crane J. (2009). Beta-(1,3)-glucan levels and its determinants in New Zealand bedrooms. Journal of Asthma 46(1):64-6. 4 Murdoch DR. et al. (2009). Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the International Collaboration on Endocarditis-Prospective Cohort Study. Archives of Internal Medicine 169(5):463-73.

12 RESEARCH REPORT 2009/2010 Professor Warren Tate from the Department of Biochemistry was the 2010 recipient of the prestigious Rutherford Medal from the Royal Society of New Zealand.

~ Divisional staff were honoured with the Health Research Council’s most prestigious award, the Liley Medal, in both 2009 and 2010. The award recognises an individual whose recent research has made an outstanding contribution to the health and medical sciences. The recipients were clinical geneticist Professor Stephen Robertson, (Women’s and Children’s Health, DSM) in 2010 and Professor Allan Herbison (Physiology, OSMS) in 2009.

~ In 2010, the University of Otago awarded its Distinguished Research Medal to Professor David Fergusson, who heads the Christchurch Health and Development Study.

~ Two of the Division’s staff were elected to Fellowships of the Royal Society of New Zealand: Professor Andy Mercer (Biochemistry) in 2009, and Professor Richie Poulton (The Dunedin Multidisciplinary Health and Development Research Unit) in 2010.

~ Carrying on a trend of first placings in recent years, Jui-Lin Fan from the Department of Physiology won the Masters Award at the MacDiarmid Young Scientist of the Year Awards for 2009.

Equipment and Facilities

~ PC3 Facility The Division has secured funding to construct a PC3 facility. This facility represents a significant advance as it will enable researchers to work directly on important human disease causing infections and pathogens. It is anticipated that this facility will facilitate work in virology, tuberculosis, and other pathogens being studied throughout the University.

~ Zebrafish Facility A world class Zebrafish Facility housed within the Department of Pathology, Dunedin School of Medicine, was officially opened in June 2009. The Director of the Facility is Dr Julia Horsfield. It hosts work being conducted by several high profile divisional research groups including those led by Dr Julia Horsfield, Professor Stephen Robertson and Professor Ian Morison, who are looking at cancer pathologies and serious human developmental diseases.

Division of HEALTH SCIENCES 13 ~ Centre for Neuroendocrinology The Division’s world leading Centre for Neuroendocrinology has new purpose built facilities to house its staff, including eight laboratories, office space and meeting rooms. The creation of a physical home for the Centre is a reflection of its incredible success in the eight years since its establishment in 2003. Since then, it has grown from a virtual centre with four laboratories involved into the largest cluster of neuroendocrinology researchers in the southern hemisphere. www.neuroendocrinology.otago.ac.nz/

~ Centre for Health Systems The Centre for Health Systems was launched in late 2010 and is housed within the Department of Social and Preventive Medicine. The Centre facilitates and promotes research into health system improvement at the University of Otago, and across the local and national health systems, as well as internationally. The Centre’s associates come from a range of University of Otago departments including those spanning our three campuses in Dunedin, Christchurch and Wellington, as well as the School of Business. It works closely with the Southern DHB and has links with a range of national and international research groups including the Commonwealth Fund, Boston University Health Policy Institute, and LSE Health.

Collaborations

~ New Zealand Genomics Limited This Divisional led consortium will provide a collaborative national infrastructure designed to accelerate New Zealand’s genomic research and technology. By providing access to a collection of highly sophisticated technologies, this infrastructure will bring together many scientists working on completely different life forms, enabling important experiments studying genetic variation and gene expression to be performed entirely within New Zealand. All New Zealand’s major universities and seven Crown Research Institutes have given their support to the infrastructure. The lead institutions are the University of Otago, AgResearch, Massey University and the University of Auckland. www.otago.ac.nz/nzgl/otago008100.html

From left: Professor Tony Reeve, Dr Rachel Elliot, Dr Mik Black, and Associate Professor Tony Merriman have taken a lead role in the establishment of New Zealand Genomics Limited.

~ Genetics Otago A new University of Otago Centre, Genetics Otago, was officially launched in July 2009. It consists of a network of genetics researchers from throughout the University and is dedicated to promoting and supporting research in all fields of genetics, within Otago and beyond. www.otago.ac.nz/genetics/

14 RESEARCH REPORT 2009/2010 ~ Centre for Bioengineering and Nanomedicine The Centre for Bioengineering and Nanomedicine was formed in late 2009. It unites bioengineering researchers at the University of Otago’s Dunedin and Christchurch campuses with partners at other Universities and from the commercial sector. The Centre aims to facilitate the commercial delivery of biomedical and scientific innovations for the benefit of New Zealand and the international community. Details of research being conducted at the Division’s two campuses can be found at: www.otago.ac.nz/bioengineering (Dunedin campus) http://bioengineering.ac.nz/ (Christchurch campus)

Publications in Nature Journals

~ The Division published thirteen papers in prestigious Nature journals in 2009 and 2010. The University of Otago was placed first in the Nature Asia-Pacific publishing rankings for New Zealand institutions in 2010. Five of the nine papers published in the Nature journals were authored by researchers from this Division.

Clarkson AN, Huang BS, MacIsaac SE, Mody I, and Carmichael, ST. (2010). Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke. Nature 468(7321): 305-9. Bahlo M, Booth DR, Broadley SA, et al. including Merriman T and Clarke G. (2009). Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. Nature Genetics 41(7): 824-U84. Calvo SE, Tucker EJ, Compton AG, et al. including Wiltshire, E. (2010). High-throughput, pooled sequencing identifies mutations in NUBPL and FOXRED1 in human complex I deficiency. Nature Genetics, 42(10): 851-858. Franke A, McGovern DPB, Barrett JC, et al. including Roberts R, Barclay M, and Gearry, R. (2010). Genome-wide meta- analysis increases to 71 the number of confirmed Crohn’s disease susceptibility loci. Nature Genetics, 42(12): 1118-1125. Gretarsdottir S, Baas AF, Thorleifsson G, et al. including van Rij AM, and Jones, GT. (2010). Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm. Nature Genetics: 42(8): 692-697. Gudbjartsson DF, Bjornsdottir US, Halapi E, et al. including van Rij AM. (2009). Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nature Genetics 41(3): 342-7. Hohmann-Marriott MF, Sousa AA, Azari AA, et al. (2009). Nanoscale 3D cellular imaging by axial scanning transmission electron tomography. Nature Methods, 6(10): 729-731. Jenkins ZA, van Kogelenberg M, Morgan T, et al. including Robertson SP. (2009). Germline mutations in WTX cause a sclerosing skeletal dysplasia but do not predispose to tumorigenesis. Nature Genetics 41(1): 95-100. Madsen LH, Tirichine L, Jurkiewicz A, et al. including Sullivan JT, and Ronson CW. (2010). The molecular network governing nodule organogenesis and infection in the model legume Lotus japonicus. Nature Communications, 1(1), 1-12. Rajabian T, Gavicherla B, Heisig M, et al. including Ireton K. (2009). The bacterial virulence factor InIC perturbs apical cell junctions and promotes cell-to-cell spread of Listeria. Nature Cell biology, 11(10): 1212-1218. Reversade B, Escande-Beillard N, Dimopoulou A, et al. including Robertson SP. (2009). Mutations in PYCR1 cause cutis laxa with progeroid features. Nature Genetics, 41(9), 1016-1021. The Australia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene), including Clarke G, Merriman M, and Merriman T. (2009). Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. Nature Genetics, 41(7), 824-828. Thorgeirsson TE, Gudbjartsson DF, Surakka I, et al. including Jones GT, and van Rij AM. (2010). Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behaviour. Nature Genetics, 42(5): 448-453. van Woerden GM, Hoebeek FE, Gao Z, et al. including Nagaraja RY. (2009). βCaMKII controls the direction of plasticity at parallel fiber-Purkinje cell synapses. Nature Neuroscience, 12(7): 823-825.

Division of HEALTH SCIENCES 15 COMMERCIALISATION

Partnering for Innovation

During 2009 and 2010, the Division led a University-wide programme funded by the TEC aimed at developing a culture of engagement with commercialisation within the staff and student body. This programme was a collaboration with the Universities of Canterbury and Lincoln and involved employing an Entrepreneur in Residence, to work with researchers to explore their ideas, move them along the commercialisation pipeline and help change the culture around commercialisation. Two cohorts of summer students were trained in intellectual property and market research and helped researchers to build business cases for their research. In addition, a seminar series showcased successful technology-based businesses to the involved researchers and created a forum for networking. This programme resulted in 22 intellectual property disclosures to the University’s Research and Enterprise Office and has led directly to one Ministry of Science and Innovation Technology Transfer Voucher being awarded in 2011.

Success Stories

• Immune Solutions Limited began development of its oral-delivery technology Liporale™ for use in human vaccines. Initial developments will be for an improved tuberculosis vaccine and a novel chlamydia vaccine. Immune Solutions’ product candidate Human Liporale™ – BCG vaccine is listed as one of the 21 next generation candidates on Stop TB Partnership’s global compilation of 2009 Tuberculosis Vaccine Candidates.

• Also in the tuberculosis field, Professor Steve Chambers (Pathology, Christchurch) and Dr Mona Syhre (now based in Germany) continued their work investigating a breath test for diagnosing tuberculosis. Professor Philip Hill (Preventive and Social Medicine) joined the expert team to support clinical field work in Bandung, Indonesia. The clinical results are being used to develop the breath test device. This project shows significant potential to advance the global fight against tuberculosis.

• HCN, the leading provider of clinical and practice-management software for Australia, has been selected by Otago Innovation Limited to distribute the TOXINZ (poison database) to hospitals and medical centres in Australia. This venture strengthens the reputation of the University of Otago’s National Poisons Centre and provides additional critical care options for Australian general practitioners and specialists. In 2010, two Australian State Governments and a number of hospitals in other states became paying subscribers.

• Professor Warren Tate and Dr Tony Cardno (Biochemistry) developed a drug-discovery screening assay to investigate a previously unexploited weakness in HIV biology and are seeking drugs to attack it. In partnership with the Walter and Eliza Hall Institute (WEHI) in Melbourne, they have been granted funding from the HRC through the International Investment Opportunities Fund, to screen for new HIV drug candidates. The WEHI’s High Throughput Screening facility is ideal for exploring the effectiveness of the assay and this may lead to a potential new drug to combat HIV-1. It is pleasing to report that the patented Otago technology has been successfully transferred to the WEHI and that screening is underway with initial results expected in early 2011.

• The 2009 Otago Innovation Proof of Concept grant attracted high-calibre applications. For the third successive year a Divisional staff member from the University of Otago, Christchurch won the award for research with commercial potential. The winner was Professor Steve Brennan from the Department of Pathology, with his anticoagulant drug candidate.

• Pacific Edge Ltd launched a new diagnostic and prognostic test for bladder cancer. CxBladder has been six years in development and determines whether a patient has superficial or invasive cancer. The test is based on research originally conducted with the Cancer Genetics Laboratory in the Department of Biochemistry. The company is establishing a laboratory in Dunedin for testing in New Zealand and Australia, and testing laboratories will be set up in Europe and the USA with local partners.

16 RESEARCH REPORT 2009/2010 RESEARCH THEMES AND CENTRES

Research Themes and Centres are areas of research and/or collaborative groups of researchers in which the University of Otago is pre-eminent and to which it gives particular recognition and support. Researchers within the Division of Health Sciences are leaders of a significant number of the University’s Research Themes and Centres. These are detailed below.

RESEARCH THEMES

Formulation and Delivery of Bioactives

Director: Professor Thomas Rades, School of Pharmacy

Website: http://pharmacy.otago.ac.nz/pages/research.html

Bioactive materials such as drugs, vaccine antigens, pesticides and nutrients cannot be administered in pure form but must be incorporated into biocompatible formulations which maintain the stability of the bioactive material and deliver it in a suitable way to achieve optimal beneficial effects while minimising unwanted side effects. Thus, the science of formulation and drug delivery has human, veterinary and agricultural applications. It combines physical chemistry, biology and materials science to investigate physico-chemical properties of bioactives, excipients and formulations and behaviours of bioactives and formulations in the biological environment in order to develop an underpinning science.

This science is the basis for design and manufacture of delivery systems with predictable behaviours. Work includes: chemical and physical stability of drugs; pharmaceutics of the solid state; colloidal systems for delivery of drugs and antigens; absorption of bioactives across biological membranes. These projects have fundamental, applied and developmental aspects.

Functional Genomics, Gene Expression and Proteomics

Director: Professor Warren Tate. Coordinator: Associate Professor John Cutfield. Department of Biochemistry, Otago School of Medical Sciences

Website: http://biochem.otago.ac.nz/university-of-otago-research-themes

The era of high throughput automated DNA sequencing and genome databases (genomics) has become an important landscape for biologists and, with it, have come new methods for identifying particular genes and their protein products (proteomics).

It is the expression of a set of genes in a particular cell type that defines the function of that cell. The pattern of gene expression can change (e.g. during development or as a result of mutation or disease) so that analysis of altered expression profiles provides fundamental information on basic biological processes. However, understanding how such changes come about requires knowledge of factors that control gene expression as well as the functions of the individual protein products. Assigning function to a protein depends strongly on knowing its precise composition and three-dimensional structure. Functional proteomics leads, in turn, to a deeper understanding of physiological processes.

Such genome-to-proteome studies rely on sophisticated technology now in place on the Otago campus that can be applied to the study of any tissue or organism. The facilities include state-of-the-art mass spectrometry and X-ray analysis for proteins, as well as a gene microarray suite, all of which have received generous support from the University. Underpinning these operations is the use of advanced methods in computational biology (bioinformatics). A number of proven investigators are embracing these new technologies with the common goal of understanding or manipulating gene expression. In addition to using common methodologies, members of this theme share a similar intellectual approach to the analysis of genes and proteins, despite the great diversity among the organisms they are studying.

Division of HEALTH SCIENCES 17 Immunological Basis of Disease and Protective Immunity (Immunet)

Director: Professor Margaret Baird: Department of Microbiology and Immunology, Otago School of Medical Sciences

Website: http://immunet.otago.ac.nz/

Understanding of the immune response underpins our understanding of infectious and autoimmune diseases. Cures for these diseases, as well as cancer and asthma, require knowledge of the immune response and how it can be manipulated. Basic and applied research is essential for both preserving and improving the health of people as well as economically important livestock. This is the only New Zealand university to teach a specific course in immunology from first year level to PhD, and one of the few in Australasia to do so.

Twenty two research groups in New Zealand are working on projects in relation to this theme. These include immunologists within the Malaghan Institute of Medical Research, Crown Research Institutes and industry. The nationwide organisation of immunologists, initiated and led by the Otago University Research Theme, is termed Immunet and its aims are to foster immunological research and the training of immunologists in New Zealand.

Research areas within this theme include those that focus on the development of novel or improved vaccines against infectious diseases and cancer, as well as projects that aim to gain a better understanding of autoimmune diseases and the role of the immune system in asthma.

Theme members have also gained experience in the testing of bioactive substances, from food and other natural products, for activity on the immune system. A number of productive research/industry collaborations have been established which have led to new patents and products. Personnel in this theme comprise postdoctoral researchers and senior scientists within the University’s Health Sciences and Sciences Divisions. Theme researchers have achieved international eminence and attract grant funding of more than $5 million per annum.

Oral Microbiology and Dental Health

Director: Dr Geoffrey Tompkins: Department of Oral Sciences, School of Dentistry

Website: http://dentistry.otago.ac.nz/research/oralmicro/index.html

Oral microbes cause discomfort, distress, or disease in a large proportion of the population. For example, tooth decay, which is caused by the bacteria present in dental plaque, is one of the most common human diseases, it is painful and it is costly to treat. Other microorganisms, such as periodontal pathogens and the yeast Candida albicans, are also present in the mouth and can give rise to oral diseases.

The research carried out under this theme aims to study the microorganisms responsible for a range of oral diseases, to understand how the diseases are caused, and to devise strategies for prevention.

Membership of the theme is drawn from five departments within the Division of Health Sciences on the Dunedin and Wellington campuses and includes 32 University staff and up to 30 postgraduate students and postdoctoral researchers. Theme members and collaborators have been awarded funding totalling more than $2 million over the last two years by a range of national and international funding bodies.

Theme members have long-term research collaborations with other national and international institutes. Current objectives include: • the extension of collaborative research activities of theme members • to increase the involvement of students in oral microbiology research • the development of interaction with the dental profession • the organisation of special symposia on oral microbiology to promote and develop the theme and to increase public awareness of the research

18 RESEARCH REPORT 2009/2010 Otago International Health Research Network

Director: Professor Philip Hill: Department of Preventive and Social Medicine, Dunedin School of Medicine

Website: http://dnmeds.otago.ac.nz/departments/psm/research/international_hlth/network/index.html

The Otago International Health Research Network, which is hosted by the Centre for International Health, fosters and builds on collaborative links across the University to contribute to the understanding and improvement of health in under-resourced countries.

The Otago International Health Research Network includes approximately 50 researchers and their students across the four divisions of the University. These researchers are conducting research across the world and are involved with major international health bodies such as WHO, CDC Atlanta and the Gates Foundation. The network administrator maintains an up-to-date list of their research activities, coordinates a regular newsletter and an annual conference, where a significant international speaker is hosted.

The major research goals of the Network are to: foster increased collaboration between researchers already doing health-related research in developing countries monitor international health funding opportunities facilitate the interaction between staff at the University of Otago and international health researchers from other countries by hosting pre-eminent international health researchers at the university for seminars and symposia identify new ways to develop the international health collaborations across the university

Oxidative Stress in Health and Disease

Director: Professor Christine Winterbourn: Department of Pathology, University of Otago Christchurch

Website: www.otago.ac.nz/christchurch/research/freeradical/index.html

Oxidative stress occurs when the production of damaging free radicals and other oxidative molecules exceeds the capacity of the body’s antioxidant defences to detoxify them. Oxidants also play an important positive role in the immune system. We live in an oxygen rich environment, and use oxygen to extract energy from food. As a corollary of this, oxygen radicals are released. The production and control of reactive oxidants, therefore, are integral life processes. However, these can be disrupted and oxidative stress contributes to many diseases including inflammation, autoimmune diseases, cancer, neurodegenerative diseases, heart attack and stroke.

The general objective of the theme is to understand the specific mechanisms of oxidative injury in these conditions and determine whether antioxidant intervention is protective.

Members of the theme are drawn from at least seven different departments, spread across three campuses, and include biochemists, clinicians and nutritionists. Current projects are investigating: • mechanisms of antioxidant defence • synthesis of targeted antioxidants • oxidative stress in premature infants • oxidative stress in cardiovascular disease • nutritional antioxidants • oxidative mechanisms of neurodegeneration, nitric oxide and mitochondrial function • host defence against infections • markers of neutrophil oxidation in inflammation • redox regulation of gene expression, cell signalling and apoptosis

Division of HEALTH SCIENCES 19 Rehabilitation and Disability

Director: Professor David Baxter, School of Physiotherapy

Website: www.rehabotago.net/

The Rehabilitation and Disability Research Theme represents a collaborative effort by researchers from diverse backgrounds. These researchers conduct high quality research that will enhance the effectiveness of rehabilitative care and optimise quality of life for persons with injury and disabilities, including those musculoskeletal, neurological, and chronic health conditions that may lead to impairment and/or disability.

Research is undertaken to improve the quality, effectiveness, and cost-effectiveness of patient care and outcomes. This includes investigations focusing on the prevention, reduction and resolution of disability, as well as quality of life for those affected by injury or disability, and the quality of life of their families and carers.

Work in this area is based upon applied research that utilises modern technology to maximise human performance, and facilitate the process of adaptation to disability; research that improves understanding of the determinants of adaptive human performance and disability within the context of impairment and/or disability; as well as investigations into the accessibility and effectiveness of patient/family education and community outreach programs.

Theme members and affiliated units and groups provide research training in a variety of specialties, including rehabilitation, neuroscience, neuropsychology, biomechanics, health care outcomes, rehabilitation engineering, and other related fields.

Due to the wide scope of our members’ specialties, from clinicians to academics, doctors, physiotherapists, health practitioners, and qualitative to quantitative researchers, we believe that a wealth of knowledge, understanding and ideas are being generated through current collaborations. In the last five years, key theme members have been awarded funding from the HRC, ACC, FRST and other funding agencies in the areas of injury, disability and rehabilitation. We are currently building on this success through increased national and international collaboration and extension into allied disciplines.

The Kidney in Health and Disease

Directors: Professor Rob Walker, Department of Medicine, Dunedin School of Medicine, Professor Zoltan Endre, Department of Medicine, University of Otago, Christchurch.

Website: http://kidney.otago.ac.nz/

The vision of this theme is to expand the Collaborative Network for Kidney Research, linking an understanding of the molecular and cellular physiology of kidney function to the clinical application of therapies that prevent kidney injury or the progression of kidney disease.

Specific long term objectives are: • to elucidate key mechanisms of renal epithelial and endothelial cell damage, following injury by different agents or mediators • to elucidate the genetic and cellular processes that lead to irreversible fibrosis or repair • to define new targets for intervention in the pathways leading to cell injury and death.

This knowledge will lead to more focused interventions that will reduce the rapidly increasing incidence of chronic kidney disease and the need for renal replacement therapy (dialysis and transplantation).

This theme involves researchers from the University’s medical schools in Christchurch and Dunedin and from departments in the wider University. The latter include the Departments of Physiology, Pathology, Pharmacology and Toxicology, and the Schools of Pharmacy and Physical Education. Strong links have been established between the researchers and nephrology colleagues at District Health Boards throughout New Zealand, as well as with other research institutions nationally and internationally. The leading researchers in this theme are all recognised internationally for their expertise. The theme is now one of the leading renal research consortiums in the Southern Hemisphere.

20 RESEARCH REPORT 2009/2010 Virology

Directors: Professors Vernon Ward and Andrew Mercer, Department of Microbiology and Immunology, Otago School of Medical Sciences

Website: http://mrna.otago.ac.nz/Virology/Virology.html

The Virology research team comprises several inter-connected groups located in the Divisions of Sciences and Health Sciences, and spread across the Dunedin and Christchurch campuses. Together, they have expertise in all areas of virology.

Current research activities of the groups encompass multiple projects in the areas of: • viruses and their role in cancer • use of viruses to deliver vaccines • structural virology • viruses as building blocks for nanomaterials • human and animal health virology • respiratory and gastrointestinal diseases • antiviral drugs • viral infections and their rapid diagnosis • vector-borne diseases: plagues past, present and future • invertebrate virology: biocontrol agents for insect pests • plant virology: threats to food security and conservation

The group has an exceptionally strong track record of publications, and collaborates internationally with research institutes in Canada, Germany, the Netherlands, Britain, the United States, Australia, Finland and Israel.

The Virology Theme has a strong commitment to supporting and training postgraduate students with more than 30 PhD and MSc students undertaking virology projects. Theme participants have won in excess of $11.5 million of funding for virology research from both national and international sources in recent years.

Memory: Mechanisms, Processes and Applications

Directors: Associate Professor David Bilkey, Dr Anthony Robins, Department of Psychology, University of Otago

Website: http://psy.otago.ac.nz//memory/

Although this theme is not led by a member of the Division of Health Sciences, Divisional staff have significant input into it. Please refer to the website above for further information.

Division of HEALTH SCIENCES 21 RESEARCH CENTRES

Cardioendocrine Research Centre

Director: Professor Mark Richards, Department of Medicine, University of Otago, Christchurch

Website: www.otago.ac.nz/christchurch/research/cardioendocrine/index.html

The Cardioendocrine Research Centre is expanding New Zealand’s capacity in cardiovascular research across the spectrum of basic and applied biomedical science to gain new knowledge of the processes determining the structure and function of the heart and blood vessels in health and disease. Common among all New Zealanders, heart disease is especially devastating to Maori and Pacific Islands people, and affects many people in mid-life, imposing a special national burden through health-care costs, loss of productivity and reduction in life expectancy.

The Centre’s mission is to advance basic and clinical research in circulating and tissue-based factors pertinent to the control of the circulation in both health and disease, with the aim of applying this new knowledge to the diagnosis, prognosis and therapy of human cardiovascular disease. It enhances the discovery of: • bio-molecules with pivotal roles in cardiovascular health and disease • gene variants associated with heart disease risk • pre-clinical assessment (isolated organ and intact animal studies) of the release and the actions of newly-discovered proteins and hormones in health and disease • disease-related changes in mechanical, chemical and electrical aspects of heart cells and tissue • prevalence of cardiovascular risk factors and established disease in Māori and non- Māori • clinical testing of new tests for diagnosis and prediction of clinical outcomes • trials of novel interventions in disorders such as heart failure

These studies are revealing the “signature” of heart disease in New Zealand and will facilitate effectively planned long-term responses, including new screening, diagnostic and therapeutic options to secure the cardiovascular health for the nation’s future. National contributions to economic transformation will accrue through the reduction of the financial and social burden of heart disease carried by New Zealanders, through the improved ability of New Zealand researchers to attract funds and through intellectual property brought to the market in diagnostic and therapeutic products.

Centre for Neuroendocrinology

Directors: Professor Allan Herbison, Department of Physiology, Otago School of Medical Sciences, Professor Dave Grattan, Department of Anatomy, Otago School of Medical Sciences

Website: www.otago.ac.nz/neuroendocrinology/

The Centre for Neuroendocrinology (CNE) comprises nine laboratories undertaking biomedical research aimed at unravelling the ways in which the endocrine and neural systems interact. The CNE is now the largest international cluster of neuroscientists focusing on how the brain controls reproduction.

Members of the CNE are leaders in cutting-edge neuroscience technologies, including the use of transgenic rodent models, and work in a integrative manner using molecular-, cellular- and systems-level approaches.

Studies extend from investigations into key neuronal cell types such as the gonadotropin-releasing hormone and oxytocin neurons, to research targeted at uncovering the multiple ways hormones such as prolactin and estrogen act back upon the brain to adapt its function to specific reproductive states. Other research in the CNE focuses on understanding the brain mechanisms controlling food intake, body fluid balance, and hormone responses to stress.

The overarching aim of research within the CNE is to bring forward fundamental biomedical insights that will enable the design of new therapies for use in the clinic.

22 RESEARCH REPORT 2009/2010 Centre for Translational Cancer Research

Director: Dr Parry Guilford: Department of Biochemistry, Otago School of Medical Sciences

The Centre for Translational Cancer Research aims to improve the outcome and well-being of cancer patients by directly addressing barriers to translational cancer research. These barriers include: • The long standing research emphasis on biological mechanisms ahead of clinical application • Difficulties in obtaining and utilising clinical samples and associated clinical data • Difficulties in implementing early experimental studies that test research development in the clinic

The Centre, which consists of cancer biologists, oncologists and surgeons, is addressing these goals through: improved communication and collaboration across disciplines within and beyond Otago; the provision of technical workshops and studentships; and the streamlined collection of informed consent, biological samples and clinical data.

Centre for Translational Research in Chronic Diseases

Director: Professor Jim Mann, Department of Medicine, Dunedin School of Medicine

Website: www.otago.ac.nz/ctrcd

The Centre for Translational Research in Chronic Diseases (CTRCD) provides expert skills and research training to tackle the need for changes in individuals’ behaviours and in the environments which currently promote ill-health.

Obesity is a major focus of research in the Centre as it is a leading preventable cause of many chronic diseases in New Zealand and worldwide. Diabetes, coronary heart disease, stroke and cancers at several important sites are all strongly associated with obesity, and the consequences of obesity for respiratory disease, bone-health, arthritis and mental health also demand action, and are areas of research interest within the Centre.

The Centre comprises multidisciplinary research groupings, including researchers from the University of Otago, Auckland University of Technology and Massey University. The Centre is closely related to the Edgar National Centre for Diabetes Research (http://www.otago.ac.nz/diabetes/) which is situated in the Department of Medicine, Dunedin School of Medicine.

Mental Health and Addiction Research Centre

Director: Professor Peter Joyce, Department of Psychological Medicine, University of Otago Christchurch

The Mental Health and Addiction Research Centre (MHARC) brings together the research activities of the Mental Health Clinical Research Unit (Director, Professor Peter Joyce), the National Addiction Centre (Director, Professor Doug Sellman) and the Gene Structure and Function Laboratory (Director, Associate Professor Martin Kennedy). Linked with the centre are two University Leading Thinkers projects in Pharmacogenomics and Bipolar Disorder.

The centre is actively involved in large-scale clinical trials in bipolar disorder, depression, bulimia, social anxiety disorder and alcohol dependence. In addition, the centre is actively involved in research on genetic markers of mood disorders, addictions and personality of subjects involved in clinical trials.

The centre is also involved in laboratory-based research on the molecular mechanisms of action of antidepressant drugs, the epigenetics of mental disorders and genetic polymorphism discovery in relationship to mental disorders.

Division of HEALTH SCIENCES 23 National Centre for Lifecourse Research (NCLR)

Co-Directors: Professor Richie Poulton, Dunedin Multidisciplinary Health and Development Research Unit, Department of Preventive and Social Medicine, Dunedin School of Medicine and Professor David Fergusson, Christchurch Health and Development Study, Department of Psychological Medicine, University of Otago, Christchurch

Website: www.lifecourse.ac.nz

The National Centre for Lifecourse Research (NCLR) is a new partnership driven by the University of Otago’s Dunedin Multidisciplinary Health and Development Research Study and the Christchurch Health and Development Study, studies that have been at the forefront of lifecourse research for almost four decades. It also involves research groups from AUT, Waikato and Victoria Universities, and the Crown Research Institute ESR, as well as a number of international partners.

It produces information and resources that feed directly into New Zealand policy and practice. Different end-user groups include policy-makers, health and science journalists, teachers, public health professionals, other researchers, funding bodies, NGO’s and the general public.

The longer term aim of the NCLR is to support and develop research that directly informs the changing needs of 21st century New Zealand society. Partner groups are already pioneering research into families, migration, and the health and development of Pacific Islanders. In the future, the NCLR will support intervention research informed by evidence from lifecourse studies.

Research Outputs: The Centre’s Outputs can be viewed at: http://www.lifecourse.ac.nz/outputs/

New Zealand Centre for Sustainable Cities

Director: Professor Philippa Howden-Chapman, Department of Public Health, University of Otago, Wellington

Website: http://sustainablecities.org.nz/

The New Zealand Centre for Sustainable Cities (CSC) has been set up to further develop collaborative research that contributes to the sustainable development of our cities. Over 87 per cent of our population live in urban environments, so we face a challenge to keep our cities sustainable and competitively attractive in international terms, and the people within them healthy and socially connected.

The CSC builds on a strong existing network of expertise. It is a partnership, led by the University of Otago, of six universities (Otago, Canterbury, Victoria, Massey, Waikato and Auckland) and three Crown Research Institutes (Landcare, NIWA and BRANZ). It is positioned to work with regional councils, territorial local authorities and national agencies, with national frameworks that can accelerate urban sustainability.

The Centre aims to work in partnerships to develop the tools to promote well-being and health in our cities through smarter economic development, safer and more sustainable housing, transport and energy systems, and enhanced urban design. The Centre is also seeking ways to support workforce development and increase the skills of those working on urban sustainability.

The research group is inter-disciplinary, and includes social scientists, public health specialists, physicists, geographers, engineers, economists, sociologists and Mäori researchers.

The Centre is planning to develop an innovative set of linked programmes that explore key factors for developing policies for sustainable cities. This will include a programme of knowledge exchange and synthesis about urban sustainability initiatives, and research to improve stakeholders’ access to relevant knowledge. The appraisal and measurement tools developed will enable sustainability choices and consequences to be made more explicit across sectors and jurisdictions. Fundamentally, this will be a programme of conceptual and empirical research on strategic urban sustainability questions that will provide a focus for future research and policy development.

24 RESEARCH REPORT 2009/2010 Sir John Walsh Research Institute

Director: Professor Jules Kieser, Faculty of Dentistry

Website: http://dentistry.otago.ac.nz/research/sjwri/index.html

The mission of the Sir John Walsh Research Institute is to advance research and increase knowledge for the improvement of oral health in New Zealand; support and represent the oral health research community in New Zealand; and facilitate the communication and application of our research findings for the benefit of oral and general health worldwide.

Because we cannot fund nor conduct research into every facet of dentistry we are focusing our attention on the following five important research programmes: • Biomechanics and oral implantology • Dental epidemiology and public health • Education research • Oral molecular and immunopathology • Molecular microbiology

The Institute also fosters and supports the Oral Microbiology and Dental Health Research Theme.

Webster Centre for Infectious Diseases

Director: Professor Kurt Krause: Department of Biochemistry, Otago School of Medical Sciences

Website: http://webstercentre.otago.ac.nz/Home.html

The Webster Centre for Infectious Diseases has as its mission the development of diagnostics, antimicrobials, and vaccines to address important problems caused by infectious diseases in New Zealand today. The need for this Centre stems from a worldwide resurgence in infectious diseases has created an environment in which new and emerging pathogens such as bird flu, SARS, and HIV are assuming prominence and pose a threat to people and also to native and domestic animals.

The Centre includes collaborations with scientists from four universities Professor Kurt Krause is a leading infectious disease specialist and the Director of the Webster Centre for and key Crown Research Institutes (ESR, IRL, and AgResearch). Infectious Diseases. As many infectious diseases are able to cross species between animals and humans, and as the protection of livestock is critical to the economic health of New Zealand, the Centre addresses problems in both human and animal health.

Historically, New Zealand has relied on therapies acquired offshore to address these threats, but advances in technology have made it feasible for New Zealand scientists to play a constructive role in protecting New Zealand citizens. The current international best practice for developing new therapies against infectious diseases is through interdisciplinary programme of scientists, involving biochemists and chemists, in collaboration with pharmacologists, microbiologists, immunologists, epidemiologists and clinicians. These groups are well-represented in the Centre, with members already collaborating with pharmaceutical companies to bring new therapies to the marketplace.

The Centre is fostering the development of a community that will fill a significant void in New Zealand’s front line of defence against infectious disease, ensuring not only the health of New Zealanders but leading to further development of a knowledge- based economy.

Brain Health and Repair Research Centre

Director: Professor Cliff Abraham, Department of Psychology, University of Otago

Website: http://psy.otago.ac.nz/staff/abraham.html

Although this Centre is not led by a member of the Division of Health Sciences, Divisional staff have significant input into the Centre. Please refer to the website above for further information.

Division of HEALTH SCIENCES 25 - - RANGAHAU HAUROA MAORI - MAORI HEALTH RESEARCH

There have been many positive developments in Mäori health research during the period of this report. In 2009, a new group of Mäori leaders from the Division’s seven schools was established to discuss and advise on issues relating to the development of Mäori at all levels within the University. Members of this group attended Te Toi Tauira mō te Matariki in 2009, a conference aimed at sharing best practice for developing Mäori in tertiary education.

In April 2010, the Division hosted its own Mäori Health Sciences Research Symposium, involving key researchers from the University of Auckland. Topics included research into Mäori student pathways and Mäori general practitioners. Later in 2010, the Pro-Vice-Chancellor, Professor Don Roberton created a new position and appointed Associate Professor Joanne Baxter as the Division’s first Associate Dean Mäori. This position oversees the development of a strategic plan for Māori research within the Division.

Areas of Research Research across the Division includes Mäori mental health, Mäori cardiovascular health, medical education in Hauora Mäori, inequalities in health and the reasons for it, indigenous health workforce issues, Mäori women’s and children’s health, Mäori oral health, gout, diabetes, physical activity and Mäori medicines and use of medicines.

Te Rop- u- Rangahau Hauora Maori- o Ngai- Tahu - Ngai- Tahu Maori- Health Research Centre, Dunedin School of Medicine

The Ngäi Tahu Mäori Health Research Unit was established in 1996 as a partnership between Te Runanga o Ngäi Tahu and the Dunedin School of Medicine at the University of Otago. The Unit has published numerous papers, articles and books on a number of aspects of hauora Mäori including hauora rangatahi (young peoples’ health); hauora wahine (Mäori womens’s health); Mäori and mental health; oranga niho (oral health) and Mäori and injury prevention.

The Unit currently has collaborative research projects with the Injury Prevention Research Unit, the Dunedin Multidisciplinary Health and Development Study and Raukura Hauora O Tainui. The Unit also assists other research groups with aspects of Mäori health research that may be part of their respective projects.

A 2010 highlight was the awarding by the HRC of $2 million to Associate Professor John Broughton, for a project aimed at improving the oral health of Mäori children by trialling an intervention in early childhood.

Website: www.otago.ac.nz/dsm/ngaitahu

Maori- and Indigenous Health Institute (MIHI) University of Otago, Christchurch

MIHI has had extensive experience in researching within Mäori communities. The Institute conducts research that assists with an understanding of Mäori health and works to develop strategies that promote Māori health gain. MIHI also has significant input into the medical curriculum. The Institute’s activities include: Contributing to the development and implementation of the undergraduate medical curriculum • Supervision and mentoring of Mäorii researchers and non-Mäori undertaking research alongside Mäori participants (this includes summer studentships, dissertations and theses). • Undertaking Mäori-focussed research, both university and community based • Collaborating with other groups and Departments within the School to develop and implement research • Working to support Iwi research development • Working with Mäori colleagues from other university-based health centres in research and teaching • Contributing to national Mäori health networks • Contributing to local and national health committees and working groups • International collaboration with indigenous health organisations from other countries

The Institute’s research interests include: the undergraduate medical curriculum; resilient indigenous health workforce networks; quality and health outcomes for Mäori; addiction and Mäori health; and cardiac disease in Mäori.

Website: www.otago.ac.nz/christchurch/research/mihi/

26 RESEARCH REPORT 2009/2010 Te Rop- u- Rangahau Hauora a Eru Pomare- - Eru Pomare- Maori- Health Research Centre University of Otago, Wellington

Te Röpü Rangahau Hauora a Eru Pömare strives to create a Kaupapa Mäori space committed to improving Mäori health outcomes and eliminating inequalities through quality science and ongoing theoretical development. It takes a rights-based approach consistent with the Treaty of Waitangi, and is engaged with community through a spectrum of influence from community development, policy advocacy, research dissemination and Mäori health.

Research outputs have been generated in the report period in the areas of cancer survival in indigenous peoples, access to services, health outcome statistics, and sleep research.

In 2010, the Centre received HRC funding for research into racism as a health determinant. There have also been other HRC successes for Mäori researchers at the University of Otago, Wellington outside of the centre.

Website: www.wnmeds.ac.nz/academic/dph/research/erupomare.html

Division of HEALTH SCIENCES 27 SCHOOLS AND DEPARTMENTS

FACULTY OF DENTISTRY

Sir John Walsh Research Institute

Director: Professor Jules Kieser. Email: [email protected]

The Sir John Walsh Research Institute within the Faculty of Dentistry provides a focus for dental research within the Faculty and also within New Zealand and the Pacific. Research carried out in the Institute underpins the teaching of dentistry, its

DENTISTRY clinical practice, and the identification of oral health related problems. The Institute draws together the research strengths within the three departments within the Faculty and groups these into five major research themes: • Biomechanics and oral implantology (including dental biomaterials, oral implantology, and forensic dentistry) • Dental epidemiology and public health • Dental education research • Molecular microbiology • Oral molecular and immunopathology

The Institute also fosters and supports the Oral Microbiology and Dental Health Research Theme.

Website: http://dentistry.otago.ac.nz/research/sjwri/index.html

DEPARTMENT OF ORAL DIAGNOSTIC AND SURGICAL SCIENCES

Head of Department: Professor Robert Love. Email: [email protected]

The Department of Oral Diagnostic and Surgical Sciences is organised into the disciplines of Oral and Maxillofacial Surgery, Oral Medicine, Oral Radiography, Oral Pathology, Special Needs Dentistry, Clinical Pharmacology and Sedation, and General Dental Practice. The main areas of research in the department are: • oral diseases and healing with particular interest in human and experimental epithelial hyperplasia, preneoplasia and neoplasia (that may lead to oral cancers) • endodontic microbiology and the molecular mechanisms involved in bacterial invasion of dentine • the development of endodontic medicinal agents for root canal disinfection and their effects on bacteria and tissues culture • clinical research in endodontics, dental implantology, oral and maxillofacial surgery, trauma, and prosthodontics.

Website: http://dentistry.otago.ac.nz/departments/odss.html

Major Areas of Research Strength

Endodontic microbiology The study and practice of endodontics is aimed at preventing and treating pulp and periapical disease. An understanding of the mechanisms of bacterial invasion of dentine and the root canal system is central to these aims. Bacterial infection of dentine has been recognised for over a century, but only recently has this research group identified the mechanisms involved in colonisation. This should lead to novel prophylactic and control treatments. Endodontic microbiological research has focused on the effect of nutritional stress on bacterial invasion of dentine, and identified that colonisation of dentinal tubules is dependent on an ideal nutritional environment, with nutritionally stressed bacterial cells losing their ability to invade.

Oral and maxillofacial surgery The discipline of Oral and Maxillofacial Surgery has a strong clinical research focus and is involved with collaborative research within the department, Faculty and externally. Particular areas of research interest include epidemiological studies of maxillofacial injuries, oral and maxillofacial pathology and general practitioner experiences in dealing with maxillofacial trauma. Clinical trials involving patients are also part of a wider research focus and current studies continue to progress which include third molar surgery, post-operative analgesics and dental implantology. A series of evidence based systematic reviews of selected aspects of maxillofacial trauma management is being developed. Expertise in ballistic and war injuries to the maxillofacial region has grown in the Associate Professor Anita Nolan is investigating department leading to a device being patented in the period. the link between oral lesions and Crohn’s disease

28 RESEARCH REPORT 2009/2010 Oral pathology Research interests in oral pathology involve immunohistochemical and PCR studies looking at the expression of various inflammatory processes in oral inflammatory lesions (e.g. periapical pathology, mucosal lichen planus) and oral malignancy (squamous cell carcinoma) in order to better understand the pathological processes involved. Investigation of expression of putative odontogenic-specific markers in odontogenic tumours and cysts is another research thread. We have recently begun a collaborative study with other groups within the University exploring the use of saliva as a diagnostic medium for the detection of human papilloma viruses. Epidemiological studies on pathology of the soft and hard tissues of the oral cavity and related structures show that the prevalence and distribution of oral pathological lesions in the New Zealand population is comparable to similar developed countries. A new focus on the linkages between oral health and autoimmune disease is being developed.

External Grants >$10,000 Awarded 2009-2010 DENTISTRY

Year PI Project Title Funder $ Approved* Approved

2010 Dr Kyoko Niimi Overcoming drench resistance FRST 923,392

2010 A/P Anita Nolan Can examining the mouth improve the New Zealand 34,000 management of Crohn’s Disease? Lottery Grants Board

2010 A/P Anita Nolan How should oral Crohn’s disease screening New Zealand 20,035 be undertaken? Dental Association

2010 Dr Hussaini Immune escape mechanisms in oral cancer Otago Medical 12,444 and lymph node metastases and their potential Research Foundation benefit in predicting clinical outcome

2010 A/P Alison Rich Immune escape mechanisms in oral cancer and New Zealand 12,274 lymph node metastases and their relationship to Dental Association clinical outcome

2009 A/P Alison Rich Endoplasmic stress, inflammation and periodontal New Zealand 14,810 disease: Unfolded protein response pathways Dental Association leading to the expression of nuclear factor KB

* GST exclusive

Postgraduate Students

Total Head Count 2009 2010

PhD 3 3 DClinDent 8 7 Masters† 2 1 † thesis or dissertation students only

Awards and Scholarships

Year Researcher Award/Scholarship

2009 Prof Robert Love Chair of the New Zealand Dental Council

Division of HEALTH SCIENCES 29 DEPARTMENT OF ORAL REHABILITATION

Head of Department: Professor Tom Kardos. Email: [email protected]

Research undertaken within the Department of Oral Rehabilitation covers a diverse range of topics related to dental education research, clinical cariology, endodontics, biomaterials, prosthodontics and dental technology. More specifically, research is directed at the prevention and treatment of dental disease, the repair and replacement of teeth and their associate structures affected by disease, trauma or wear, the restoration of form, function and appearance, mechanical testing and computer modelling of the behaviour of dental tissues and biomaterials.

DENTISTRY Website: http://dentistry.otago.ac.nz/departments/oralrehabilitation.html

Major Areas of Research Strength

Oral biomechanics and biomaterials Investigations focus on a range of mechanically mediated responses of dental materials and biological tissues, ranging from the influence of mechanical forces on the stresses developed in the mandible to the stresses and failure mechanics of restorations. This research has significant bearing on the design longevity and anticipated failure of implant-supported structures. Major inroads have been made into the understanding of the stresses developed in craniofacial structures as a consequence of biting forces. The use of CT-based images and computer modelling has enabled researchers to predict the mechanics of failure of complex dental restorative systems. This will lead to a more rational design and selection of materials for tooth restorations.

Oral implantology Clinical and laboratory-based research relating to implant dentures and single-tooth implants is conducted. The aim is to improve the oral health-related quality of life of the ageing population. The Department’s evidence-based treatment approach of reducing the delay between oral implant placement and loading with the prosthesis is internationally recognised. Current research aims to identify and quantify the pre-load stress developed on the peri-implant bone and prosthetic framework as a result of misfit using a recently developed mandible replica.

Oral Public Health There is a growing research focus in this area with an emphasis on caries prevention.

External Grants Awarded 2009-2010

Year PI Project Title Funder $ Approved* Approved

2010 Lara Friedlander The topographical and functional relationship of New Zealand 14,867 coronal dental pulp cells Dental Association Research Foundation

2010 Sunyoung Ma Ceramic implants supporting overdentures Kate Sheppard 2,500 Memorial Award Trust

* GST exclusive

Postgraduate Students

Total Head Count 2009 2010

PhD 6 6 DClinDent 16 14 Masters† 1 2 † thesis or dissertation students only

Awards and Scholarships

Year Researcher Award/Scholarship

2010 Mr John Boyens Fellowship of the International College of Dentists

2010 Dr Sunyoung Ma Kate Sheppard Memorial Award

30 RESEARCH REPORT 2009/2010 DEPARTMENT OF ORAL SCIENCES

Head of Department: Professor Richard Cannon. Email: [email protected]

Research conducted within the Department includes molecular microbiology, oral immunology, oral biology, dental anthropology, craniofacial growth, clinical dentistry, public health dentistry and teaching delivery. Molecular microbiology serves as the flagship of the Faculty’s research effort and is part of the University’s Oral Microbiology and Dental Health Research Theme.

Website: http://dentistry.otago.ac.nz/departments/oralsciences.html DENTISTRY Major Areas of Research Strength

Dental epidemiology and public health The Dental Epidemiology and Public Health Group investigates the oral health of populations, with particular attention given to the natural history of dental disease and health through childhood, adolescence and adulthood. Collaborations with two world-renowned projects are ongoing - the Dunedin Multidisciplinary Health and Development Study (a prospective observational study of a cohort of New Zealanders born in 1972-73) and the South Australian Dental Longitudinal Study (a prospective observational study of a cohort of older South Australians).

Forensic dentistry Areas of research interest include: the biomechanics of wounding; marine decomposition; and bite marks and personal identification. A key recent project has involved the bacteriological fingerprinting of bite marks, where the unique streptococci bacteria transferred by a bite may be used to identify offenders in sex crimes or child abuse. Another project of note is the development of various models which reliably replicate blunt trauma impact events. An interdivisional research project has been launched which is aimed at the admissibility of expert forensic evidence. The team consists of dental researchers and others from the Faculty of Law, the School of Pharmacy, and the Dunedin School of Medicine.

Molecular microbiology This research aims to study the microorganisms responsible for a range of oral diseases, to understand how the diseases are caused, and to devise strategies to prevent them. Investigations are underway into how periodontal bacteria acquire the haem they require for growth, as preventing this access may help prevent periodontal disease, and how bacteria colonise and invade dentinal tubules, which can lead to endodontic infections. DNA sequencing technology is being used to analyse the ‘metagenome’ associated with oral health and periodontal disease. Additional major areas of research include microbial adhesion and oral fungi that cause mucosal and systemic infections, antifungal drug resistance and antifungal drug discovery.

Oral immunopathology The main objective of this group is to explore the cellular and molecular basis of oral diseases, so as to improve their diagnosis and treatment. Three major themes include: (i) periodontal diseases, (ii) oral mucosal disease including oral squamous cell carcinoma, and (iii) tissue regeneration. In terms of periodontal disease the focus is on using the peripheral blood and salivary transcriptomes in the determination of susceptibility, the use of metagenomics to determine the oral microbiota and epigenetics to determine the influence of environmental factors such as smoking. The relationship with systemic diseases is also being investigated, as are the immunopathological mechanisms underpinning oral mucosal disease. In collaboration with the University of Queensland, the group is conducting a five-year longitudinal clinical study on the relationship between periodontal and cardiovascular diseases. This study has attracted over $3 million in funding in recent years.

External Grants > $15,000 Awarded 2009-2010

Year PI Project Title Funder $ Approved* Approved

2010 Dr Kyoko Niimi Overcoming drench resistance FRST 923,392

2010 Dr Brain Monk Multifunctional azoles: A triple whammy Royal Society of 730,435 designed to defeat drug resistance New Zealand Marsden

2010 Dr Warwick Duncan Comparison of SLA or SL active implants ITI Foundation 69,388 placed in the maxillary sinus with or without (subcontract) synthetic bone graft materials

2010 A/P Bernadette Hypomineralised enamel in molar-incisor New Zealand Dental 47,044 Drummond hypomineralisation Association Research Foundation

Division of HEALTH SCIENCES 31 2010 Prof Richard Cannon Tissue culture incubator for dental research New Zealand Dental 14,980 Association Research Foundation

2010 Prof Jules Kieser Treatment of dry mouth with microemulsions New Zealand Dental 14,956 Association Research Foundation

2009 Prof Murray Thomson Oral health to age 38 Health Research 1,005,527 Council of NZ DENTISTRY 2009 Prof Richard Cannon Targeting melanoma initiation and progression: Health Research Council 333,622 developing ABCB5 inhibitors of NZ – International Investment Opportunities Fund

2009 Prof Murray Thomson Trends of facial fractures in New Zealand Health Research Council 57,800 of NZ

2009 Alison Meldrum Improving the oral health of preschoolers – New Zealand Dental 20,971 implementation of a tool for oral health Association Research professionals Foundation

2009 Prof Jules Kieser Backspatter of blood from cranial gunshot ESR 17,000 wounds

2009 Prof Murray Thomson Microbial analysis of dental plaque samples in Otago Medical Research 15,185 the Dunedin Multidisciplinary Health and Foundation Development study

* GST exclusive

Postgraduate Students

Total Head Count 2009 2010

PhD 11 13

DClinDent 19 21

Masters† 3 3 † thesis or dissertation students only

Awards and Scholarships

Year Researcher Award/Scholarship

2010 Prof Jules Kieser Fellowship of the International College of Dentists

2010 Prof Murray Thomson H. Trendley Dean Memorial Reward, International Association for Dental Research

2010 A/P Mary Cullinan Fellowship of the International College of Dentists

2010 Prof Richard Cannon Sir John Walsh Research Institute Publication Award

2010 Prof Murray Thomson Sir John Walsh Research Award, for research over an extended period by a member of the Faculty of Dentistry

2009 Prof Murray Thomson Alan Docking Award for distinguished work in dental research

2009 Prof Murray Thomson Fellow of the Academy of Dentistry International

2009 A/P Bernadette Drummond Fellowship, New Zealand Dental Association

32 RESEARCH REPORT 2009/2010 FACULTY OF MEDICINE

OTAGO SCHOOL OF MEDICAL SCIENCES

DEPARTMENT OF ANATOMY

Head of Department: Professor Dave Grattan. Email: [email protected]

Research activity within the Department of Anatomy covers a wide range of topics including: neuroscience, reproductive biology, developmental biology, clinical and functional anatomy, biological anthropology, and cell biology. OSMS

The Department boasts a number of first-rate research facilities including gene sequencers, light microscopy facilities (including a laser capture micro-dissection system and a Zeiss inverted microscope), X-ray and ultrasound, dedicated image analysis suites, a plastination laboratory, and an extensive human skeletal remains collection. The Department also houses the Otago Centres for Electron Microscopy and Confocal Microscopy.

Website: http://anatomy.otago.ac.nz/

Major Areas of Research Strength

Neuroendocrinology Research focuses on the neuroendocrine functions of the hormone prolactin, and in particular, the role of prolactin in the neuroendocrine and neurobiological adaptations of the maternal brain. Specific interests include the control of appetite and body weight during pregnancy and obesity, plasticity in oxytocin neurons during late pregnancy and lactation, and the role of prolactin in changes in mood and behaviour in the post partum period. The link between nutrition and fertility is also being investigated.

Basal ganglia research Dysfunction of the basal ganglia contributes to disorders such as Parkinson’s disease, Huntington’s disease, attention-deficit hyperactivity disorder (ADHD) and schizophrenia. The Basal Ganglia Research Group is particularly interested in the functioning of the striatum, the region primarily involved in processing information that enters the basal ganglia from other brain areas. This region contains the vast majority of the brain’s neurochemical dopamine. Dopamine is released into the striatum by activity of cells that reside in a part of the midbrain known as the substantia nigra pars compacta (SNc). A better understanding of the normal functioning of cells in the striatum and in the SNc will pave the way to better treatments for disorders of the basal ganglia.

Sexual differentiation of the brain Men and women are differentially affected by most neurological diseases. Males are more likely to develop ADHD and motor neuron disease whereas anorexia nervosa is associated more with females. This group has found that a hormone active in the development of the sex organs in the male embryo, Mullerian inhibiting substance (MIS), is also present in the brain, creating a sex difference there too. MIS produces subtle differences in both the size and number of motor neurons between the two sexes, potentially explaining why men are more susceptible to motor neuron disease than females. Ongoing research will investigate how MIS also regulates other parts of the brain. It is hoped that this research could, in time, contribute to more effective treatments for some neurological disorders.

Clinical and functional anatomy There is an active research programme in clinical and functional anatomy in the department. Particular emphasis is placed on issues relevant to surgical and physiotherapy practice. Current areas of research include: the clinical anatomy of vascular structures, deep fasciae, the musculoskeletal system, and the head and neck region. Additional studies are focusing on the blood supply of the major duodenal papilla, the microstructure of the ileocaecal junction, and the complex anatomy of the cavernous sinus. Investigations into the morphological factors that contribute to dysphagia (difficulty swallowing) are also ongoing. A variety of techniques are utilised including: gross dissection, microdissection, E12 sheet plastination, SEM, TEM, confocal microscopy, corrosion casting; and MRV and Digital Subtracted Angiography.

Biological anthropology A particular area of research interest is the biological anthropology of prehistoric populations in Southeast Asia and the Pacific. This research uses skeletal remains from archaeological excavations as the primary source of data. Specific interests include health and disease as evidence of adaptation to the environment, with an emphasis on infant and child health and disease. An additional research focus is identifying the origins of Pacific peoples and their commensal plants and animals in order to better understand the settlement, history and prehistory of the Pacific and New Zealand.

Division of HEALTH SCIENCES 33 Other research The Department of Anatomy is a research-intensive department and has a number of other research strengths including: alcohol and brain development; bioethics; molecular embryology; schizophrenia; development of bone graft substitutes and composite surgical appliances; reproduction and genomics; skeletal muscle developmental biology; and molecular mechanisms of learning and memory.

External Grants > $50,000 Awarded 2009-2010

Year PI Project Title Funder $ Approved* Approved OSMS 2010 Prof Ian McLennan Drugs for frailty FRST 2,382,222

2010 A/P John Reynolds Improving brain function: a balancing act Royal Society of 1,000,000 New Zealand Marsden

2010 Dr Andrew Clarkson Sonic Hedgehog Facilitates Post-Stroke Axonal Health Research 880,407 Sprouting and Functional Recovery Council of NZ

2010 Dr Caroline Larsen Neurogenesis and postpartum anxiety Royal Society of 260,870 New Zealand Marsden Fast Start

2010 A/P Dorothy Oorschot Anatomy of the GABAergic synaptic Neurological Foundation 182,739 innervation to dopaminergic neurons in the of New Zealand circuitry of non-reward

2010 Dr Andrew Clarkson Defining the functional role of post-stroke New Zealand Lottery 100,000 brain excitability in repair Grants Board

2009 Dr Elspeth Gold Role of activin C in prostate disease Health Research 953,697 Council of NZ

2009 Prof Dave Grattan Mechanisms of hyperprolactinemia-induced Health Research 949,105 infertility Council of NZ

2009 A/P John Reynolds Dopamine and learning – it’s all in the timing Royal Society of 853,333 New Zealand Marsden

2009 Prof Neil Gemmell Investigating the genetic basis for and adaptive Royal Society of 773,333 significance of cryptic female choice in an New Zealand external fertiliser – the chinook salmon Marsden

2009 Dr Greg Anderson The link between nutrition and fertility Health Research 739,575 Council of NZ

2009 Prof Lisa Matisoo-Smith Redrawing the Polynesian Triangle: Did Polynesian Royal Society of 710,000 settlement extend to South America? New Zealand Marsden

2009 Dr Greg Anderson Sex steroids: new regulators of brain SOCS Royal Society of 653,333 New Zealand Marsden

2009 Dr Hallie Buckley Lapita diet and health in Vanuatu: Human Royal Society of 536,889 adaptation to a virgin island environment New Zealand Marsden

2009 Dr Andrew Clarkson Turning post-stroke cortical excitability: Health Research 500,000 implications for learning and memory Council of NZ

34 RESEARCH REPORT 2009/2010 2009 Dr Sian Halcrow Health and Social Change in Prehistoric Royal Society of 266,667 Southeast Asia New Zealand Marsden Fast Start

2009 Dr Janette Quennell Infertility, body fat and kisspeptin: making the Royal Society of 266,667 connections New Zealand Marsden Fast Start

2009 Dr Ping Liu Agmatine and age-related cognitive decline: Neurological 166,114 a microdialysis and EM study Foundation of

New Zealand OSMS

2009 Dr Shakila Rizwan Development of a new tool for treating Neurological 136,854 epilepsy: on-demand seizure prevention Foundation of New Zealand

2009 Prof Dave Grattan Role of PI3K on the hypothalamic regulation TEC (subcontract) 131,013 of energy homeostasis

2009 Dr Ming Zhang What limits spread of local anaesthetic in New Zealand 122,139 the neck? Lottery Grants Board

2009 Lisa Smith Correlating expression of dopamine receptors Neurological 105,483 with mechanisms of movement learning in single Foundation of neurons of the striatum New Zealand

2009 A/P Dorothy Oorschot Equipment purchase essential to the New Zealand 100,000 advancement of biomedical research Lottery Grants Board

2009 A/P John Reynolds Correlating expression of dopamine receptors Neurological 99,900 with mechanisms of movement learning in single Foundation of neurons of the striatum New Zealand

2009 Prof Jean Fleming Investigating the cell of origin of epithelial ovarian Genesis Oncology 74,319 cancer through BRCA1 knockdown Trust

2009 A/P Dorothy Oorschot Neuron and motor skill rescue after neonatal New Zealand 73,721 hypoxia-ischemia: Therapies Lottery Grants Board

* GST exclusive

Commercial Contracts

Year Approved Organisation

2009-10 AgResearch LabPLUS Auckland District Health Board Cawthron Institute CSIRO ESR Griffith University Lincoln University Massey University Waikato University Landcare Lanzatech New Zealand Forest Research Institute New Zealand Institute for Plant and Food Paua Industry Council Ltd

Division of HEALTH SCIENCES 35 Plant and Food Research University of Auckland University of Canterbury University of Sydney University of Wollongong ViaLactia Biosciences Victoria University

Total 1,160,748 OSMS Postgraduate Students

Total Head Count 2009 2010

PhD 37 39

Masters† 14 15

† thesis or dissertation students only

Awards and Scholarships

Year Researcher Award/Scholarship

2010 Dr John Reynolds Rutherford Discovery Fellowship, Royal Society of New Zealand

2010 A/P Nancy Tayles OSMS Excellence in Postgraduate Supervision Award

2010 Hayden McEwen Maurice Wilkins Centre Research Scholarship (PhD student)

2010 Lisa Smit Miller Scholarship, Neurological Foundation (MSc student)

2010 Tessa Sanders National Research Centre for Growth and Development Scholarship (PhD student)

2010 Stefan Prost Allan Wilson Centre Scholarship

2009 Priya Prasad Genesis Oncology Trust PhD Scholarship PhD student)

2009 Melissa Barry Miller Scholarship, Neurological Foundation (PhD student)

2009 Thomas McCowan TEC Bright Future Top Achiever Doctoral Scholarship (PhD student)

36 RESEARCH REPORT 2009/2010 DEPARTMENT OF BIOCHEMISTRY

Head of Department: Professor Kurt Krause. Email: [email protected]

Research in the Department is largely concerned with fundamental processes associated with a number of significant biomedical and biological problems: heart disease; cancer; diabetes, rheumatoid arthritis and gout; memory and neurological disease; pathogenic viruses, micro-organisms and fungi; flowering, senescence, photosynthesis, nitrogen utilization in plants, symbiosis; mammalian preimplantation, embryo development; cold adaptation; eukaryotic retroelements; developmental biology; body weight and cell signalling; molecular evolution; apoptosis; biodiversity. Extensive use is made of bioinformatics, microarray technology and proteomics tools. The Otago Genomics Facility, the Centre for Protein Research and the X-ray facility for protein structure determination are all located within the Department. Departmental staff are involved in New OSMS Zealand Genomics Ltd, a new entity supplying national infrastructure for fast through-put sequencing.

Website: http://biochem.otago.ac.nz/

Major Areas of Research Strength

Cancer genetics The Cancer Genetics Laboratory (CGL) is the hub for cancer genetics research within the department. Research interests are fourfold: Wilm’s tumour and genomic imprinting; stomach cancer; colorectal cancer; and leukaemia. The overall aim of the research is to elucidate the genetic events leading to cancer, in order to improve diagnostic methods and assist in the design of better therapies. The CGL has identified genetic and epigenetic mechanisms involved in the onset of Wilm’s tumour, which develops in the kidneys of young children. Researchers are investigating the nature of the environmental and genomic factors involved in childhood acute lymphoblastic leukaemia, with a particular emphasis on epigenetic mechanisms. Another project is concentrating on identifying the causes of stomach cancer, with an emphasis on the inherited form of the disease. A defective gene leading to familial stomach cancer was identified which enabled the screening of high risk Māori families to identify carriers who then undergo surveillance for early cancer detection.

Website: http://cancer.otago.ac.nz/

Functional genomics, gene expression and proteomics The era of automated DNA sequencing and genome databases (genomics) has arrived and with it have come new methods for identifying particular genes and their protein products (proteomics). It is the expression of a set of genes in a particular cell type which defines the function of that cell. The pattern of gene expression can change, for example during development, or as a result of mutation or disease, so that analysis of altered expression profiles provides fundamental information on basic biological processes. Understanding how such changes come about requires knowledge of factors that control gene expression as well as the functions of the individual protein products. Assigning function to an unknown protein depends on knowing its precise composition and 3-dimensional structure, as well as its interaction partner. Functional proteomics leads in turn to a deeper understanding of physiological processes.

Structural biology of infectious diseases There is a worldwide resurgence in infectious diseases which pose a threat to our population and to our native and domestic animals. Researchers are seeking to develop diagnostics, antimicrobials and vaccines to address important problems caused by such diseases. The molecular structures of proteins inside infectious viruses and microbes are being probed to seek out weaknesses that can be exploited. New drugs to combat these diseases can then be designed. Specific disease targets are tuberculosis, HIV/AIDS, streptococcal disease, poxviruses, Candida and MRSA. Research efforts have been bolstered by the recent creation of the Webster Centre for Infectious Diseases and by the establishment of a high-flux protein crystallography laboratory in the Department.

Autoimmune disease Research focuses on the underlying genetics of gout and rheumatoid arthritis, two common forms of autoimmune diseases. Large databases of DNA obtained from sufferers of autoimmune diseases are being used to identify causative genes. Researchers have confirmed that the gene PTPN22 is one of the factors that causes rheumatoid arthritis, only the second gene in the past 25 years to be universally accepted as a causative factor. The group has also developed microarray technology which has allowed a genome-wide scan to simultaneously test all genes for association with rheumatoid arthritis. This technology is being applied to other chronic conditions in order to uncover their pathogenesis, including abdominal aortic aneurysm, schizophrenia, gout and inflammatory bowel disease.

Other research The Department of Biochemistry is a very research-intensive department and has a number of other areas of research strength including: bioinformatics, bacterial molecular biology; evolution and development; plant biochemistry; proteomics; and heart disease. Many of these project areas are funded by the HRC, FRST or Marsden grants.

Division of HEALTH SCIENCES 37 External Grants > $50,000 Awarded 2009-2010

Year PI Project Title Funder $ Approved* Approved

2010 A/P CatherineDay Uncovering how inhibitor of apoptosis proteins Health Research 991,989 promote cell survival Council of NZ

2010 A/P Peter Dearden Constraining and buffering evolution: how do Royal Society of 728,696 complex gene networks evolve? New Zealand

OSMS Marsden

2010 Dr Anita Dunbier Estrogen receptors and genetic susceptibility to Health Research 500,000 breast cancer Council of NZ - Charles Hercus Research Fellowship

2010 Dr Parry Guilford Molecular diagnostic test for the prediction of Health Research 296,649 survival and drug response in ovarian cancer Council of NZ/A*STAR

2010 Dr Hohmann-Marriott Photosystem II - the enzyme that never sleeps Royal Society of 260,870 New Zealand Marsden Fast Start

2010 Dr Cushla McKinney Identification of immune-system genes associated Arthritis 103,983 with progression from hyperuricaemia to gout New Zealand

2010 Prof Iain Lamont Antibiotic resistance mechanisms of Cure Kids 103,035 Pseudomonas aeruginosa in cystic fibrosis

2010 Prof Iain Lamont Determining time of death by blood protein FRST 101,667 analysis

2010 Dr Cushla McKinney Identification of genes contributing to progression New Zealand 94,000 from hyperuricaemia to gout Lottery Grants Board

2009 Dr Stephanie Hughes The Transcription factor code: Maintaining Royal Society of 831,111 neuronal identity and function in the adult brain New Zealand Marsden

2009 Dr Craig Marshall Ecology, physiology and phylogeography of FRST 600,000 Antarctic terrestrial invertebrates

2009 Prof Warren Tate Drug delivery targeting novel step in Health Research 395,538 HIV-1 biology Council of NZ – International Investment Opportunities Fund

2009 A/P Iain Lamont Cracking the non-ribosomal code Royal Society of NZ 267,016

2009 Dr Miriam Sharpe A bright future: New Zealand glowworm FRST – Postdoctoral bioluminescence as a biotechnological tool Fellowship 267,000

2009 Dr Hohmann-Marriott Utilising nanowires to plug into New Zealand’s FRST – Postdoctoral 267,000 microbial solar cells Fellowship

2009 A/P Parry Guilford Epigenetic approaches to cancer prevention Royal Society of New 200,000 and therapy Zealand – James Cook Fellowship

2009 Dr Chris Brown In search of conserved mRNA localization and Human Frontier 165,837 anchoring mechanisms Science Programme

38 RESEARCH REPORT 2009/2010 2009 Prof Kurt Krause Broad spectrum antimicrobials targeting the National Institutes 237,599 D-Alanine pathway of Health (subcontract)

2009 Prof Tony Reeve How does the WTX tumour suppressor New Zealand 92,439 gene function? Lottery Grants Board

2009 A/P Russell Poulter Resolution of mitochondrial mixtures ESR 81,000

2009 Dr Mik Black Gene pairs as biomarkers for improved breast New Zealand 73,019

cancer prognosis prediction Breast Cancer OSMS Foundation

2009 Dr Stephanie Hughes Developing viral vector gene therapy for CLN5 Neurological 69,498 and CLN6 Batten disease in ovine models Foundation of NZ (subcontract)

2009 A/P Catherine Day Understanding the activity of IAP antagonists Genesis Oncology Trust 66,064

2009 Prof Anthony Reeve WTX: A puzzling tumour suppressor gene Cancer Society 50,000 of New Zealand

2009 A/P Russell Poulter Cyclotides: synthesis of a novel class of New Zealand bio-active cyclic peptides Lottery Grants Board 50,000

* GST exclusive

Commercial Contracts

Year Approved Organisation

2009-10 Abacusbio Ltd AgResearch Meat Livestock Australia New Zealand Antarctic Institute New Zealand Forest Research Institute NIWA Onegenetix Otago Innovation Ltd

Total 626,695

Postgraduate Students

Total Head Count 2009 2010

PhD 39 41

Masters† 18 9

† thesis or dissertation students only

Division of HEALTH SCIENCES 39 Awards and Scholarships

Year Researcher Award/Scholarship

2010 Prof Warren Tate Rutherford Medal, Royal Society of New Zealand

2010 A/P Catherine Day Life Technology Award, New Zealand Society of Biochemistry and Molecular Biology

2010 A/P Catherine Day OSMS Distinguished Researcher of the Year

OSMS 2010 A/P Peter Dearden OSMS Best Paper Award

2010 Dr Anita Dunbier Sir Charles Hercus Research Fellowship, Health Research Council

2010 Tony Zaharic OUSA Teacher of the Year

2010 Dr Miriam Sharpe FRST New Zealand Science and Technology Postdoctoral Fellowship

2009 A/P Parry Guilford James Cook Research Fellowship, Royal Society of New Zealand

2009 Rowan Herridge (PhD student) TEC Bright Future Top Achiever Doctoral Scholarship

2009 Prof Andy Mercer OSMS Distinguished Researcher of the Year

2009 Dr Liz Ledgerwood OSMS Best Paper Award

2009 Tracy Josephs Elmann Poole Travelling Scholarship (PhD student)

2009 Tony Zaharic OUSA Teacher of the Year

Associate Professor Catherine Day’s research explores how a number of proteins involved in apoptosis interact and how this knowledge can be then exploited for the development of improved therapeutics for diseases such as cancer

40 RESEARCH REPORT 2009/2010 DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY

Head of Department: Professor Frank Griffin. Email: [email protected]

The main research interests of staff in the Department of Microbiology and Immunology lie in the areas of agricultural microbiology, biotechnology, clinical microbiology and infectious diseases, food-borne pathogens, microbial genetics, immunology, bacteriophage molecular biology, innate immunity and vaccine technology. Research is carried out in the following key areas: antibiotic resistance in bacteria, clostridial genetics, dendritic cells and their function, environmental microbiology and bioremediation, insect viruses and the biological control of insect pests, intestinal microflora, milk products, mycobacterial diseases of animals, microbial genomics, nitrogen fixing bacteria and improving plant growth, streptococci and the biological control of streptococcal diseases, vaccine development and delivery systems, viruses and viral vaccines. OSMS

Website: http://micro.otago.ac.nz/

Major Areas of Research Strength

Viral technologies A principal goal of virus research is to characterise virus to host interactions. Many viruses are a threat because they express a plethora of factors that subvert, suppress and generally manipulate human defences against infection. Viral factors that have been discovered and characterised include a set of chemokine binding proteins, a cytokine, a new class of vascular endothelial growth factor, a potent apoptosis inhibitor, a cell cycle regulator and a family of proteins that exploit the cell’s ubiquitination machinery. These viral factors target critical elements of our defences, and their analysis gives important new insights into both viral pathogenesis and our own physiological processes. There is also the opportunity to exploit these novel viral factors as new therapeutics in the treatment of pathologies quite removed from virus infection, for example, non-healing wounds and inflammatory disorders.

Immunology An understanding of the immune response underpins studies of infectious and autoimmune diseases. Cures for these diseases, as well as cancer and asthma, require knowledge of the immune response and how it can be manipulated. Research focuses on the development of vaccines against cancer and infectious diseases such as Chlamydia, Johne’s Disease and tuberculosis. A major theme is the study of the cells and the molecules involved in antigen presentation during immune responses to allogeneic transplants. Research also seeks to understand the immunology of autoimmune inflammatory diseases and the role of the immune system in asthma and other allergies.

Disease in animals Research in the Disease Research Laboratory (DRL) targets immunity to mycobacterial infections in domestic livestock (sheep and deer) and wildlife (Cape buffalo). All facets of immunity to infection including improved diagnosis, vaccination and selection for heritable resistance are studied. Diagnostic tests developed by the Laboratory are used extensively for immune profiling of Mycobacterial diseases in ruminants. The main diseases being studied are Tuberculosis (TB) which is caused by Mycobacterium bovis and Johne’s disease (JD) which is caused by Mycobacterium paratuberculosis.

Gastrointestinal microbiology Complex communities of bacteria inhabit the bowels of animals and have important influences on health and disease. These communities are referred to as the gut microbiota. Research projects include the microbiology of inflammatory bowel diseases, the use of a unique colony of Lactobacillus-free mice in investigating the molecular foundations of gut autochthony using lactobacilli as model bacteria, engineering bowel communities by dietary manipulation, and the impact of bifidobacterial species on the activation of human dendritic cells with respect to atopic diseases.

Bacterial physiology Research in this area focuses on how bacteria function under different environments. The membrane proteins and signaling pathways involved in this adaptation and how they control the physiological response of a particular bacterium to environmental signals is a major theme. These studies utilise modern technologies (e.g. proteomics, transcriptomics, molecular biology and structural biology) to address important questions in bacterial adaptation to environment.

Division of HEALTH SCIENCES 41 External Grants > $50,000 Awarded 2009-2010

Year PI Project Title Funder $ Approved* Approved

2010 Prof Andy Mercer Human pathogenic viruses: Drug targets and Health Research 4,978,146 therapeutic potential Council of NZ

2010 Dr Keith Ireton Molecular mechanism of cell-cell spread of National Institutes 1,497,443 Listeria in polarized epithelial cells of Health

OSMS 2010 Dr Keith Ireton Molecular mechanism of spreading of microbial Royal Society of 682,609 pathogens: studies with the bacterium Listeria New Zealand monocytogenes Marsden

2010 Prof Frank Griffin Genes and markers: Molecular markers for Johne’s Consortium 150,000 resistance

2010 Prof Greg Cook Identification and characterisation of the Auckland University 133,000 regulatory system controlling oxygen utilisation in Mycobacterium tuberculosis in response to hypoxia

2010 A/P Alex McLellan Multicolour flow cytometer New Zealand Lottery 100,000 Grants Board

2010 Prof Vernon Ward Macrophage responses to norovirus infection New Zealand Lottery 90,000 Grants Board

2010 Prof Greg Cook ATP synthase inhibitors: new drugs in the fight New Zealand Lottery 81,000 against tuberculosis Grants Board

2010 Dr Keith Ireton Role of the human PI 3-kinase pathway in New Zealand Lottery 54,000 internalization of Listeria Grants Board

2010 Dr Peter Fineran Virulence gene control TEC Priming 52,000 Partnerships

2009 Prof Greg Cook What determines the size of the c ring in a Royal Society of 742,222 nanomolecular machine New Zealand Marsden

2009 Prof Greg Cook Why are hydrogenases found in the genomes Royal Society of 720,000 of aerobic bacteria? New Zealand Marsden

2009 Dr Peter Fineran Bacterial protection against phage infections: Royal Society of 669,333 converging themes in toxin-antitoxin and New Zealand abortive infection systems? Marsden

2009 Prof Greg Cook Molecular approaches to TB persistence Health Research 602,003 and pathogenesis Council of NZ (subcontract)

2009 A/P Alex McLellan A new role for T cell help in the immune Royal Society of 507,556 response New Zealand Marsden

2009 Prof Frank Griffin Novel molecular markers for identifying Johne’s Consortium 150,000 resistant phenotypes in red deer

42 RESEARCH REPORT 2009/2010 2009 Dr Ros Kemp T Cell mediated regulation of colorectal cancer Health Research 133,413 immune responses Council of NZ

2009 Prof Gerald Tannock Mechanisms of colitis induced by defined National Institutes 120,288 bacterial flora of Health (subcontract)

2009 Prof Vernon Ward How do viruses get inside protein crystals? Royal Society of 109,899 NZ Marsden (subcontract)

OSMS 2009 Dr Jimmy Leong Cancer-causing papillomaviruses: Genesis Oncology Trust 70,054 reprogramming of the immune response

* GST exclusive

Commercial Contracts

Year Approved Organisation

2009-10 AgResearch Fonterra Research Centre Ltd LactoPharma

Total 785,618

Postgraduate Students

Total Head Count 2009 2010

PhD 35 39

Masters† 9 6 † thesis or dissertation students only

Awards and Scholarships

Year Researcher Award/Scholarship

2010 Prof Frank Griffin Pickering Medal, Royal Society of New Zealand

2010 Dr Heather Brooks OSMS Distinguished Academic Teacher Award

2010 Htin Aung Maurice Wilkins Centre PhD Scholarship (PhD student)

2010 Mark Robinson Division of Health Sciences Exceptional PhD thesis (PhD student)

2010 Dr Michael Berney Swiss Society of Microbiology Encouragement Award

2010 Julia Prier Proudfoot Prestigious Scholarship in Experimental Science

2010 Prof Andy Mercer Chair in Viral Pathogenesis

2010 Prof Gerald Tannock Senior Researcher Award

2009 Prof Andy Mercer Senior Researcher Award

Division of HEALTH SCIENCES 43 2009 Prof Andy Mercer Fellow of the Royal Society of New Zealand

2009 Dr Sarah Young University of Otago Early Career Award for Distinction in Research

2009 Prof John Tagg Life Membership of the New Zealand Microbiological Society

2009 Dr Ros Kemp Health Research Council Emerging Researcher Award

2009 Sarah Saunderson Lotteries Health PhD Scholarship (PhD student) OSMS 2009 Matthew McNeil TEC Bright Future Top Achiever Doctoral Scholarship (PhD student)

DEPARTMENT OF PHARMACOLOGY AND TOXICOLOGY

Head of Department: Associate Professor Rhonda Rosengren. Email: [email protected]

The Department of Pharmacology and Toxicology engages in high quality, internationally-recognised research focused on the following themes: cellular and molecular neuropharmacology, neurodegeneration, neuroprotection and neurotoxicology: cardiovascular signalling and cardioprotection; cancer drug development, drug metabolism, drug treatment of chromic pain and vestibular pharmacology. State-of-the-art technologies, including in vivo disease models, are used to undertake integrative, cellular and molecular investigations aimed at understanding animal and human pathophysiology, and to delineate targets for novel drugs.

Website: http://phal.otago.ac.nz/

Major Areas of Research Strength

Disorders of the vestibular system Members of the Vestibular and Auditory Research Group are interested in the functional deficits observed in the CNS following damage to the inner ear. These deficits include balance disorders, loss of gaze holding ability, disruption of hearing including tinnitus, and of surprise to many people, cognitive dysfunction. Questions relating to these disorders are pursued in a human testing facility within the Department.

Cancer drug development Research focuses on the development of novel treatments for cancer. This includes using medicinal chemistry to design novel glutathione peroxide mimics and nitric oxide donors, which can be used to treat a variety of cancers. Synthetic chemistry is also used to design novel drugs to specifically target triple negative breast cancer, a highly aggressive form of breast cancer. Nanotechnology and tumor homing peptides are then used to specifically deliver the drug to the tumor.

Drug treatment of chronic pain Chronic pain is often caused by damage to the central nervous system, and can be very difficult to treat. Recent research has shown that this ‘neuropathic pain’ can be caused by inflammation within the central nervous system. The Department investigates the mechanisms underlying this process and how to alter them with new drugs, aiming to develop new and improved treatments for chronic pain.

44 RESEARCH REPORT 2009/2010 External Grants > $20,000 Awarded 2009-2010

Year PI Project Title Funder $ Approved* Approved

2010 Dr Yiwen Zheng Neurogenesis in the cochlear nucleus following Deafness Research 48,305 noise-induced tinnitus Foundation of New Zealand

2010 A/P Rhonda Rosengren The use of raloxifene as an adjuvant drug Otago Medical 28,767

treatment for estrogen receptor negative Research Foundation OSMS breast cancer

2010 Dr Greg Giles Photoactivated nitric oxide donor drugs as Otago Medical 25,665 anti-cancer agents Research Foundation 2010 Dr John Ashton Opioid-induced hyperalgesia and chronic Otago Medical 23,346 pain syndrome Research Foundation

2009 Prof Paul Smith Does stimulation of the vestibular inner ear Royal Society of 800,000 enhance memory? New Zealand Marsden

2009 A/P Rhonda Rosengren Synthetic cannabinoids for the treatment of Otago Medical 34,264 estrogen receptor negative breast cancer Research Foundation

2009 A/P David Clark Effect of statins on behaviour Otago Medical 25,000 Research Foundation

*GST exclusive

Commercial Contracts

Year Approved Organisation

2009-10 New Zealand Food Safety Authority Lincoln University

Total 214,596

Postgraduate Students

Total Head Count 2009 2010

PhD 17 14

Masters† 3 8 † thesis or dissertation students only

Awards and Scholarships

Year Researcher Award/Scholarship

2010 Shane Hellyer University of Otago Prestigious PhD Scholarship (PhD student)

2010 Courtney Breen Todd Foundation Award for Excellence (BSc Honours student)

2009 Chelsea Goulton TEC Bright Future Top Achiever Doctoral Scholarship (PhD student)

Division of HEALTH SCIENCES 45 DEPARTMENT OF PHYSIOLOGY

Head of Department: Associate Professor Pat Cragg. Email: [email protected]

The Department of Physiology is engaged in high quality, internationally-recognised physiological research focused on the three major themes of Cardiovascular and Respiratory Physiology, Cellular and Molecular Neuroscience, and Membrane and Ion Transport.

Members of the Department use state-of-the-art technologies, including transgenic mouse models, synchrotron radiation, and single molecule detection in living cells, to undertake integrative, cellular and molecular investigations aimed at understanding

OSMS animal and human physiology.

Website: http://phsl.otago.ac.nz/

Major Areas of Research Strength

Neuroendocrine control of reproduction Fertility is declining in western societies, including New Zealand. Major research being undertaken in the Department through the Centre for Neuroendocrinology is focused on understanding the ways in which the brain controls reproduction, including the onset of puberty, ovulation, birth and lactation. Recent research has shown that a newly-discovered protein that is essential for puberty, kisspeptin, also plays a critical role in the control of ovulation by mediating estrogen’s actions in the adult brain – a finding that may offer hope to the infertile. On-going work aims to determine how dysfunction of the brain circuits that regulate fertility might lead to polycystic ovarian syndrome, the leading cause of infertility in women. Other current research focuses on whether kisspeptin and another protein, prolactin, might be involved in preterm labour: these proteins also act in the brain to alter the secretion of the hormone, oxytocin, which controls uterine contractions at birth.

Website: http://www.neuroendocrinology.otago.ac.nz/

Neurological disorders and the control of movement Neurological disorders are an increasing health problem, particularly in an aging population. Unfortunately, many of these disorders, including those that impair movement and restrict mobility, are common, often poorly treated and get progressively worse over time. As a result they create a significant health burden for patients and carers alike. Research in the Department aims to address these problems by exploring the brain circuits and signals that initiate and refine movement and how these signals are transmitted via the spinal cord and muscles to engage movement. Recent research has identified how even a mild mis-timing of the signals from a brain region called the cerebellum causes significant loss of fine movement control. Our ultimate aim is to identify therapeutic targets, approaches and devices for the early and better treatment of Parkinson’s disease, ataxia (lack of coordination), sarcopenia (age-related muscle weakness), spinal injury, multiple sclerosis, epilepsy and Alzheimer’s disease.

Membrane and ion transport This theme centres around investigations into the mechanisms and regulation of solute and water movement across cell membranes and resultant pathologies. Current areas of interest include the regulation of epithelial ion channels and transporters by binding proteins, solutes and pharmacological agents; epithelial fluid and electrolyte transport in the intestine and the interaction of bacteria with the intestine; the role of calcium transport proteins in intracellular calcium signalling; and the control of sodium, potassium, urate and water handling by the kidney.

Cardiovascular and respiratory physiology Research is conducted into cardiovascular and respiratory control and disease processes such as atherosclerosis, heart failure, obesity, pulmonary hypertension, renal failure, rheumatoid arthritis and systemic hypertension. Specific areas of interest include: neural control of the heart and vasculature of the lungs, kidneys and skeletal muscle; inflammation; exercise and fatigue. Recent investigations have demonstrated that control of the cardiovascular system by the nervous system adversely changes in heart failure and pulmonary hypertension; and that the hormone gherlin has protective effects after a heart attack.

46 RESEARCH REPORT 2009/2010 External Grants > $50,000 Awarded 2009-2010

Year PI Project Title Funder $ Approved* Approved

2010 Dr Colin Brown Kisspeptin-oxytocin regulation of pregnancy: Health Research 709,665 implications for preterm delivery Council of NZ

2010 Dr Rebecca Campbell Primary cilia and the central regulation of Royal Society of 500,000 fertility New Zealand Marsden

OSMS 2010 Dr Peter Jones Physiological and pathological regulation of Royal Society of 266,667 the cardiac ryanodine receptor (RyR2) by New Zealand RyR2-interacting proteins Marsden Fast start

2010 Dr Andrew Bahn Translational control of urate transporters via Health Research 149,884 microRNAs Council of NZ

2010 Dr Paul Hessian An investigation of the molecular pathways that Arthritis 64,709 link smoking and rheumatoid inflammation New Zealand

2009 Prof Allan Herbison Neural regulation of fertility Health Research 3,242,207 Council of NZ

2009 Dr Ruth Empson The Transcription Factor Code: maintaining Royal Society of 831,111 neuronal identity and function in the adult brain New Zealand Marsden

2009 A/P Brian Hyland New pathways for new learning – probing a Royal Society of 782,223 novel brain circuit for associating environmental New Zealand Marsden stimuli with rewards

2009 Dr Colin Brown Hormonal regulation of bodyweight in Royal Society of 728,884 reproduction New Zealand Marsden

2009 A/P Grant Butt The development of possum specific toxins AgResearch 678,000

2009 Dr Louise Role of basal ganglia input on motor thalamus Neurological 191,442 Parr-Brownlie activity in Parkinson’s disease Foundation of New Zealand

2009 Dr Sam Lucas Towards new treatments for obstructive and National Heart 180,000 central sleep apnoea using HA exposure Foundation

2009 A/P Brain Hyland Role of dorsal raphe in regulating reward Neurological 170,000 prediction by midbrain dopamine neurons Foundation of New Zealand

2009 Prof Allan Herbison Metabolic targeting of GnRH neurons: European Commission 65,526 Molecular mechanisms and neuropeptide (subcontract) pathways

*GST exclusive

Commercial Contracts

Year Approved Organisation

2009-10 Boehringer-Ingelheim Pty Ltd Germany

Total 774,152

Division of HEALTH SCIENCES 47 Postgraduate Students

Total Head Count 2009 2010

PhD 32 39

Masters† 8 6 † thesis or dissertation students only

Awards and Scholarships OSMS

Year Researcher Award/Scholarship

2010 Prof Allan Herbison OSMS Excellence in Postgraduate Supervision Award

2010 Dr Daryl Schwenke OSMS Emerging Researcher of the Year Award

2010 Rob Porteous OSMS Research Support Staff Award

2010 Dr Jenny Clarkson Finalist, MacDiarmid Emerging Scientist Award

2010 Sue Deans University of Otago Award for Exceptional Performance by General Staff

2010 Dr Andrea Kwakowsky Postdoctoral Poster Prize, 7th International Congress of Neuroendocrinology, Rouen, France

2010 Dr Paul Hessian and ACR Notable Poster Award, American College of Rheumatology Annual Scientific Meeting, Marina Kazantseva Atlanta, USA (PhD student)

2010 Shel Hwa Yeo PhD Poster Prize, 7th International Congress of Neuroendocrinology, Rouen, France (PhD student)

2010 Dr Matt Bevin Best Lecturer Award, Medical Student’s Association; and one of the 10 Best Lecturers at the University, OUSA

2010 Dr Ruth Empson, Best Poster Price, Australasian Winter Conference on Brain Research Helena Huang, Yeri Kim (BBiomedSc student)

2010 Michel Herde Physiological Society of NZ Mary Bullivant Oral Presentation Prize, Medical Sciences Congress (PhD student)

2010 Natalie Joe Physiological Society of NZ Mary Bullivant Poster Presentation Prize, Medical Sciences (BSc(Hons) student) Congress

2010 Natalie Joe OSMS Dean’s Prize for the best summer research project 2009/2010 (BSc(Hons) student)

2009 Prof Allan Herbison Liley Medal, Health Research Council of New Zealand

2009 Jui-Lin (Mickey) Fan MacDiarmid Young Scientist of the Year Awards - Masters Award

2009 Dr Rebecca Campbell University of Otago Early Career Award for Distinction in Research

2009 Dr Rebecca Campbell FRST New Zealand Science and Technology Postdoctoral Fellowship – Bridge to Employment

2009 Dr Jenny Clarkson FRST New Zealand Science and Technology Postdoctoral Fellowship

2009 Dr Emma Coddington Grass Fellowship to carry out research at the Marine Biological Laboratories, Massachusetts, USA

48 RESEARCH REPORT 2009/2010 2009 Rosemary Brown Physiological Society of NZ John Hubbard Memorial Prize for Excellence in Studies towards (PhD student) a PhD

2009 Sue Deans OSMS Distinguished Research Support Staff Member Award

2009 Mike Gill Physiological Society of NZ Mary Bullivant Poster Award (PhD student)

2009 Zsombor Koszegi First prize, OMSRS PhD and MD Student Speaker Awards (PhD student) OSMS 2009 Heng-Jia (Tina) Liu OSMS Dean’s BBiomedSc Hons Price (BBiomedSc Hons student)

2009 Beth Mallard Prime Minister’s Scholarship (PhD student)

2009 Shel Hwa Yeo Physiological Society of NZ Mary Bullivant Oral Award (PhD student)

Division of HEALTH SCIENCES 49 DUNEDIN SCHOOL OF MEDICINE

DEPARTMENT OF GENERAL PRACTICE AND RURAL HEALTH

Head of Department: Associate Professor Jim Reid. Email: [email protected]

The Department houses the Royal New Zealand College of General Practitioners Otago Research Unit, a group of international standing and one that is renowned for its general practice research in health services, health policy, and a wide range of clinical areas. The Department also runs an extensive programme of clinical research in rural medicine, medical education and teaching about primary care research design and methods. DSM Website: www.otago.ac.nz/dsm/gp

Major Areas of Research Strength

Rural medicine Research incorporates issues of rural practice and service provision and includes: the role of the rural hospital generalist and in particular the interface with base hospital specialists; student attitudes to rural practice; rural hospital services; and rural hospital cardiology including pre hospital fibrinolysis and management of acute coronary syndromes in the rural setting.

Medical education This is a major theme with teaching staff actively conducting research into teaching and learning at undergraduate and postgraduate level. Areas of research interest include: the hidden curriculum in medical education; communities of clinical practice; socialisation in medical training; distance learning; professionalism in medicine; evaluation of medical courses and curricula; education and vocational training for rural hospital generalists; and reflective practice.

General practice research This is a broad research theme that encompasses clinical and professional topics within the discipline of general practice. Examples of specific areas of research include: childhood obesity; prison doctoring; immunisation; doctor/patient relationships; diabetes; health care fees and charges; and pharmacovigilance,

Primary healthcare Research encompasses broader issues around the provision of primary care and policy development and implementation. Research interests focus mainly on patient safety; primary care structure and infrastructure; workforce; and quality measures.

External Grants >$20,000 Awarded in 2009-2010

Year PI Project Title Funder $ Approved* Approved

2010 Dr Garry Nixon Impact of generalist clinician-performed Health Research 200,000 ultrasound and echocardiography in rural NZ Council of NZ

2009 A/P Susan Dovey A comparison of treatment modalities and New Zealand 62,727 outcomes of treatment for rural and urban Breast Cancer women in NZ who have been diagnosed with Foundation breast cancer

2009 Dr Katharine Wallis Regulating for Patient Safety in Primary Care Emily Johnston 55,263 Scholarship

2009 Dr Katharine Wallis Assessing and improving the safety culture in World Health Dunedin primary care practices Organisation 26,265

*GST exclusive

50 RESEARCH REPORT 2009/2010 Postgraduate Students

Total Head Count 2009 2010

PhD 2 2

Masters† 6 5 † thesis or dissertation students only

Awards and Scholarships DSM

Year Researcher Award/Scholarship

2010 Dr Garry Nixon Distinguished Fellowship, the Royal New Zealand College of General Practitioners

2010 Dr Katharine Wallis Emily Johnson Scholarship

2010 Dr Katharine Wallis Claude McCarthy Fellowship

2009 Dr Pat Farry Member of the New Zealand Order of Merit for services to rural medicine

2009 Dr Garry Nixon Peter Snow Memorial Award for rural health research and service, Rural General Practitioners Network

2009 Dr Katharine Wallis Emily Johnson Scholarship

DEPARTMENT OF MEDICAL AND SURGICAL SCIENCES

Head of Department: Professor Rob Walker. Email: [email protected]

The Department of Medical and Surgical Sciences was established in 1999 to facilitate multidisciplinary interactions between the six speciality sections in order to enhance teaching and research output. Up until the end of 2010, the six sections within the Department were: ~ Anaesthesia and Intensive Care ~ Bioethics Centre ~ Medicine ~ Ophthalmology ~ Orthopaedic Surgery ~ Surgery

In January 2011, the Department of Medical and Surgical Sciences was dissolved and its constituent sections were restructured. The sections of Anaesthesia and Intensive Care, Orthopaedic Surgery, and Surgery were combined to form the Department of Surgical Sciences. The Ophthalmology and Medicine sections were similarly amalgamated into the Department of Medicine. The Bioethics Centre became a stand alone unit within the Division of Health Sciences. The research activities of these sections and departments will be presented below as they stood in 2009-10.

ANAESTHESIA AND INTENSIVE CARE

Head of Section: Dr Geoff Laney. Email: [email protected]

Research activity in the Anaesthesia and Intensive Care Section relates mainly to clinical pharmacology of paracetamol, and evidence-based practice anaesthesia practice.

Website: www.otago.ac.nz/dsm/anaesthesia

Division of HEALTH SCIENCES 51 BIOETHICS CENTRE

Director of Centre: Professor Gareth Jones. Email: [email protected]

The wide range of research projects and activities of the Centre aims to examine the conventional and novel moral dilemmas arising from medical research, clinical settings, and advances brought about by life sciences and biotechnologies. Great efforts are focused on exploring previously rarely-chartered areas and innovative conceptual and methodological approaches. The Centre is committed to active engagements with social and public policy issues at local, national and international levels.

Website: http://healthsci.otago.ac.nz/bioethics/index.html DSM Major Areas of Research Strength

Reproductive ethics Ethical considerations in the use of reproductive technologies, and ethical issues arising from social policy in the area of reproduction: IVF, surrogacy, pre-implantation genetic diagnosis, one-child policy in China.

Human enhancement Human performance, behaviour and appearance can be increased beyond that which is normally expected. Enhancement like this is contrasted with therapy or conventional treatment. Examples are cognitive enhancement, enhancement in sport, and cosmetic surgery. Transhumanism represents extreme vistas, with its possibilities of vast life extension.

Philosophy and mental health Is there any such thing as mental disorder? If there is, what kind of thing is it? If coercion can sometimes be justified in psychiatry, what are the circumstances? Exploring the conceptual status of psychotic hallucinations and delusions, and whether psychiatry should be replaced by cognitive neuroscience.

Philosophy and medicine The relationship between biomedical science and clinical practice, and whether diseases be regarded realistically, pragmatically or as social constructs. The status of complementary and alternative medicine. What role should evidence-based medicine have in medical decision making?

Cross-cultural ethics Mäori perspectives on genetic biotechnologies and health care, the nature of indigenous knowledge, medical ethics in China, Confucian and Daoist perspectives on bioethics, Chinese voices on abortion, the ideology and ethics of China’s birth control program, the ethics of population engineering in the east and west, Japan’s wartime medical atrocities and international aftermath, the search for a transcultural bioethics.

Neuroethics The overlap between neuroscience and ethics creates problems involving neuroimaging and information use, moral aspects of personhood and brain changes that explain behaviour or affect a person’s identity, and the ethical importance of consciousness.

Postgraduate Students

Total Head Count 2009 2010

PhD 5 7

Masters† 6 5 † thesis or dissertation students only

52 RESEARCH REPORT 2009/2010 MEDICINE

Head of Section: Professor Rob Walker. Email: [email protected]

Collaborative research projects link the Section of Medicine with other departments in the Division, as well as other universities in New Zealand and around the world. Areas of particular research strength include: rheumatic diseases, gastroenterological diseases, endocrinology, kidney disease, diabetes research, bone fractures in children and obesity, cardiac disease, falls in the elderly, cancer and respiratory illnesses.

Website: www.otago.ac.nz/dsm/medicine DSM Major Areas of Research Strength

Diabetes research The Edgar National Centre for Diabetes Research (ENCDR) houses New Zealand’s foremost diabetes research team, involving a range of disciplines, including nutrition, epidemiology, health services research, Māori health, biostatistics, public health and social marketing. Research aims to reduce the incidence of diabetes and its complications by finding new ways to prevent and manage the disease. Studies attempt to address the problem of diabetes and obesity by education, support and the promotion of healthy lifestyles in both children and adults. The Centre for Translational Research in Chronic Diseases (CTRCD), which is affiliated to the ENCDR, is charged with the responsibility of evaluating the government’s public health approach to improving nutrition and physical activity and reducing obesity and its co-morbidities.

Website: www.otago.ac.nz/diabetes/

Respiratory disease The causes, treatment and prevention of asthma are the central foci of The Otago Respiratory Research Group. Key studies have revealed that not all asthmatics suffer from the same type of inflammation and not all will respond to commonly used inhaled steroid treatment. Studies are now being undertaken to identify alternative forms of treatment for this group. The group had previously revealed that long-term cannabis smoking is likely to produce similar adverse effects to tobacco smoking (chronic bronchitis, emphysema and lung cancer), and that the effects are noticeable even after smoking for a short time. In more recent times, a study has revealed that obesity can worsen the impact and severity of asthma.

Kidney disease Members of this group are dedicated to investigating innovative ways to prevent and treat kidney disease. The group’s expertise ranges from molecular and cellular-level investigations of kidney function, to applying therapies to prevent kidney injury or the progression of kidney disease. Efforts are underway to find new markers for early acute renal failure so it can be treated before irreversible damage or death occurs. Current research projects include: effects of lithium on renal function, therapeutic targets of polycystic kidney disease, dietary induced obesity and metabolic syndrome, clinical renal trials, renal function and high performance exercise, and progression of renal disease.

Rheumatology Research under this theme is varied. Major interest centres on the pathogenic pathways of rheumatoid arthritis. This research is attempting to determine the relationships of this classification to clinical outcomes, pathophysiologic pathways and treatment responses. The genetics of rheumatoid arthritis and gout is another area of strong research focus. A key project is “Genetics of Gout in Aotearoa” which is part of a $3.4m HRC programme grant led by Associate Professor Tony Merriman (Biochemistry, OSMS). Other areas of interest include ankylosing spondylitis, correlates of fatigue in chronic arthritis and scleroderma. With regard to the latter, researchers in the department contribute to EUSTAR - an international collaborative project to study the natural history of scleroderma.

External Grants > $20,000 Awarded in 2009-2010

Year PI Project Title Funder $ Approved* Approved

2010 Prof Rob Walker Dialysis outcomes in those aged 65 years Health Research 772,060 and over Council of NZ

2010 A/P Rachael Taylor Healthy Homework: A physical activity and Health Research 280,449 nutrition intervention for children Council of NZ (subcontract)

2010 Dr Chris Jackson Top Gear: Trial of preoperative therapy for Cancer Society of 55,000 gastric and esophagogastric junction New Zealand adenocarcinoma

Division of HEALTH SCIENCES 53 2010 Prof Rob Walker The BLOCADE Trial Health Research 41,506 Council of NZ (subcontract)

2010 Prof Rob Walker The impact of renal tubular function on drug Otago Medical 31,908 handling in the elderly Research Foundation

2009 A/P Rachael Taylor Screening, feedback and treatment of overweight Health Research 1,307,272 in 4-8 year old children Council of NZ

DSM 2009 A/P Rachael Taylor Improving school playgrounds to enhance Health Research 799,244 physical activity in children Council of NZ

2009 Dr Rachael McLean Sodium in NZ, intake, consumer perceptions Health Research 250,000 and implications for chronic disease Council of NZ

2009 A/P Patrick Manning The effect of thermally oxidised polyunsaturated National Heart 61,412 fat on postprandial glycaemia Foundation of NZ

2009 Prof Rob Walker The pivotal role of cAMP in renal tubular injury Kidney Health 32,035 New Zealand

2009 Prof Rob Walker Red blood cell survival in patients with chronic Otago Medical 26,287 kidney disease and on dialysis Research Foundation

*GST exclusive

Commercial Contracts

Year Approved Organisation

2009-10 Commonwealth of Australia Flinders Medical Centre New Zealand Food Safety Authority New Zealand Society for the Study of Diabetes Suturox Ltd

Total 319,508

Postgraduate Students

Total Head Count 2009 2010

PhD - 1

Masters† 12 11 † thesis or dissertation students only

Awards and Scholarships

Year Researcher Award/Scholarship

2010 A/P David Gerrard Lifetime Achievement Award, New Zealand Sport and Recreation Sector Awards

54 RESEARCH REPORT 2009/2010 OPHTHALMOLOGY

Head of Section: Professor Anthony Molteno. Email: [email protected]

The Ophthalmology Section has an active research focus. Major research areas include: the Otago Glaucoma Surgery Outcome Study, Internet based medical education, UV photography of the cornea, and long-term follow-up of orbital implants, diabetic retinopathy, and falls prevention in the visually impaired elderly in the Falls Prevention Study with the Department of Medicine.

Website: www.otago.ac.nz/dsm/ophthalmology

Major Areas of Research Strength DSM

Glaucoma Glaucoma is the number one cause of preventable blindness in New Zealand. The Otago Glaucoma Surgery Outcome Study is based in the department and is the world’s longest ongoing follow-up study into surgery for glaucoma. Approximately 1400 patients have been followed to determine outcomes following implant surgery or trabeculectomies at Dunedin Hospital since 1976. Aspects of the study have included: the development of an effective draining implant for previously severe or untreatable glaucoma; investigations into interactions between the glaucoma aqueous from the eye, the implant itself and the patient’s tissues; and the development of drug regimes for use with implants in conventional glaucoma surgery to improve results. The electronic database of operations in the Otago Glaucoma Surgery Outcome Study now provides data for studies aimed at defining the long-term results of glaucoma drainage surgery.

External Grants Awarded in 2009-2010

Year PI Project Title Funder $ Approved* Approved

2010 Prof Tony Molteno Glaucoma Surgery Outcomes Study Healthcare Otago 49,757 Charitable Trust

*GST exclusive

Postgraduate Students

Total Head Count 2009 2010

PhD - -

Masters† 3 3 † thesis or dissertation students only

ORTHOPAEDIC SURGERY

Head of Section: Associate Professor Jean-Claude Theis. Email: [email protected]

Research interests in the Orthopaedic Surgery Section include: orthopaedic surgery and joint replacement, spinal and scoliosis surgery, paediatric surgery, joint arthroplasty, hand and upper limb surgery, cartilage repair, and the development of bioabsorbable orthopaedic implants. There are also two commercially funded units within the Department, both of which have as their prime interests, the reactions of tissues to surgical implants.

Website: www.otago.ac.nz/dsm/orthopaedics

Major Areas of Research Strength

Paediatric surgery and screening The major research interests are ultrasound imaging of the neonatal hip and epidemiology and screening of developmental dysplasia of the hip (DDH or clicky hip). All babies born in New Zealand hospitals will undergo a physical examination to check for DDH, a disorder where the thigh bone can easily dislocate from the hip socket. However, DDH is a difficult diagnosis. An innovative screening programme involves scanning at risk babies with ultrasound imaging. This programme has dramatically reduced the number of children with DDH, and has also reduced the number of babies who are misdiagnosed with the disorder and treated unnecessarily.

Division of HEALTH SCIENCES 55 Joint repair and orthopaedic implants Researchers are studying the cellular mechanisms of joint injury and repair, with particular emphasis placed on the biology and function of articular cartilage in a joint. The ultimate goal is the engineering of new cartilage that could be inserted into a damaged joint to restore it to normal pain-free functioning. The development of bioabsorbable orthopaedic implants is an additional research theme. Types of implants under development include: an absorbable suture anchor for the attachment of soft tissue to bone; and absorbable interference screws for the fixation of bone-tendon-bone grafts in anterior cruciate ligament reconstruction.

External Grants > $20,000 Awarded in 2009-2010

DSM Year PI Project Title Funder $ Approved* Approved

2010 Dr Haxby Abbott Optimising cost-effectiveness in the Health Research 500,000 management of osteoarthritis Council of NZ

2010 A/P Tony Poole Fundamentally cilia: cellular cybernetics and Royal Society of 220,000 the primary cilium New Zealand – James Cook Research Fellowship

2010 A/P Tony Poole Cell and tissue bio-banking to study primary Otago Medical 35,000 cilia defects in a sheep model of Meckel-Gruber Research Foundation syndrome

2009 Prof Jean Claude Theis Dunedin Acute Back Pain Study New Zealand Lottery 27,836 Grants Board

*GST exclusive

Postgraduate Students

Total Head Count 2009 2010

PhD 1 2

Masters† - - † thesis or dissertation students only

Awards and Scholarships

Year Researcher Award/Scholarship

2010 Prof Jean-Claude Theis Officer of the New Zealand Order of Merit

2010 A/P Tony Poole James Cook Fellowship

2010 Dr Haxby Abbott Sir Charles Hercus Research Fellowship, Health Research Council of New Zealand

56 RESEARCH REPORT 2009/2010 SURGERY

Head of Section: Professor Andre van Rij. Email: [email protected]

The department of Surgery aims to excel in clinical teaching and training, the linking of basic science with clinical research and the development of the discipline in New Zealand and internationally. The Section of Surgery has three major research units: The Vascular Research Group, the Colorectal Translational Research Group, and the Otago Clinical Audit and Outcomes Research Group.

Website: www.otago.ac.nz/dsm/surgicalsciences DSM Major Areas of Research Strength

Vascular disease research The Vascular Research Group undertakes research in the fields of vascular biology, genetics and physiology. The group has a wide range of basic science and clinical skills, including molecular biology (genomics, transcriptomics and proteomics), immunohistopathology, cell culture and vascular physiology (ultrasonography). The group’s primary research interests are: ~ The genetic basis of different forms of vascular disease including abdominal aortic aneurysm, coronary artery disease, lower limb arterial disease, stroke and varicose veins. ~ Determining the early processes in the formation of atherosclerosis. ~ The identification of circulating markers of vascular susceptibility and/or post-interventional outcome. ~ Determining the pathophysiology of venous disease. Professor Andre van Rij (right) and Associate Professor Greg Jones lead the Vascular Research Group.

Researchers in this group have played a major role in a multi-national collaboration identifying a new genetic marker for increased risk of abdominal aortic aneurysm and other common diseases of the arteries and veins. This study has been published in the prestigious journal Nature Genetics5.

Website: http://dnmeds.otago.ac.nz/departments/surgery_sci/surgery/research/vascular.html

Colorectal translational research The Colorectal Translational Research Group was formed in 2010 to co-ordinate and strengthen existing strands of research into colorectal cancer and to promote the translation of laboratory discoveries into the clinical environment. It consists of a collaboration of researchers combining expertise from a broad range of disciplines, including surgery, medical oncology, molecular biology, bioinformatics, immunology and experimental biology. One of the Group’s core strengths is its clinical base; from which it procures tissue samples linked to clinical outcome data for laboratory-based research, and recruits patients into clinical trials.

The main research areas are: ~ Genetic and epigenetic factors in colorectal cancer ~ Prognostic tests for colorectal cancer ~ Immune response to colorectal cancer ~ Immunotherapy for colorectal cancer ~ Immune mechanisms in Crohn’s disease

Since its inception in 2010, the Group has procured funding to pursue its strategic goals, has extended its tissue bank and clinical database, and is initiating several new clinical trials: investigating the role of vitamin D in colorectal cancer and the management of acute appendicitis.

5 Gretarsdottir S, Baas AF, Thorleifsson G, et al. including van Rij AM, and Jones, GT. (2010). Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm. Nature Genetics: 42(8): 692-697.

Division of HEALTH SCIENCES 57 Clinical audit and outcomes research The Otago Clinical Audit and Outcomes Research Group promotes the development of clinical audit within the surgical profession and develops systems for evaluating longer term outcomes in clinical practice. The Unit has produced significant research focusing on the process of surgical audit including risk stratification in outcome assessment.

A key example of the Unit’s activities is the development of a successful national system for audit for vascular surgery. Data on 55,000+ patients is available in the audit database to assist peer-review, to answer enquiries from clinical management, to determine surgical workloads, to monitor training of registrars and to evaluate overall surgical performance.

Website: www.otago.ac.nz/ouaudit/ DSM External Grants > $20,000 Awarded in 2009-2010

Year PI Project Title Funder $ Approved* Approved

2010 A/P Magnus Thorn Surgery followed with immunotherapy Anderson Trust 53,250

2010 A/P Magnus Thorn Immunological mechanism and experimental HealthCare Otago 26,250 therapy Charitable Trust

2009 Prof John McCall Antigen presentation to T cells in human lymph Health Research 991,603 nodes Council of NZ

2009 Prof John McCall T cell mediated regulation of colorectal cancer Health Research 133,413 immune responses Council of NZ

2009 A/P Greg Jones Identifying circulating markers for abdominal New Zealand 50,000 aortic aneurysms Lottery Grants Board

2009 Mr Patrick Dawes Effect of a short post-operative course of oral Healthcare Otago 33,442 prednislone on post-operative morbidity Charitable Trust following tonsillectomy

2009 Prof John McCall Cirrhosis and beta-blockade Auckland Medical 25,000 Research Foundation

*GST exclusive

Postgraduate Students

Total Head Count 2009 2010

PhD 3 5

Masters† 1 2 † thesis or dissertation students only

Awards and Scholarships

Year Researcher Award/Scholarship

2010 Professor John McCall Research Development Investment Award, DSM

2009 Tina Chen Clinical Research Scholarship, DSM (PhD student)

2009 Helena Tsao Best Paper Award, New Zealand Vascular Society (PhD student)

58 RESEARCH REPORT 2009/2010 DEPARTMENT OF PATHOLOGY

Head of Department: Professor Ian Morison. Email: [email protected]

The department has a strong research culture with the major themes being cancer, developmental biology and molecular pathology. Much of the research is multidisciplinary in approach, is clinically relevant, and involves collaboration with clinical and scientific colleagues in other Departments within the School, University or elsewhere in New Zealand, as well as international links.

The Department houses a number of research groups: the Cell Transformation Group (PI: Braithwaite), Epigenetics and

Cancer (Morison), the Developmental Genetics and Pathology Group (Eccles), the Chromosome Structure and Development DSM Group (Horsfield), the Molecular Genetics Laboratory (Markie), the Immune Therapeutics group (Young), and the Molecular Pathology Group (Fitches).

Website: www.otago.ac.nz/dsm/pathology

Major Areas of Research Strength

Cancer research A major research theme in the Department is cancer research. The over-arching interest of the department is the identification, characterisation and functional analysis of genes that contribute to the development of cancer. This includes genes responsible for rare inherited predispositions to cancer, as well as genes that are defective in the more common sporadic forms of cancer. There is a strong focus on identifying suitable ‘markers’ for cancer diagnosis. These markers are useful in screening large populations, in detecting patients with cancer at an early stage, and in monitoring patients after treatment for recurrence. In addition, there is a focus on developing new therapies for treating cancer. Cancers that are being studied include colorectal, breast, and brain cancer, melanoma, leukaemia, lymphoma and myelodysplastic syndrome. A particular emphasis is also placed on the function of specific cancer genes, such as TP53, TES, MYCN, and YB-1 and in cancer vaccine development.

Developmental genetics Several research groups have a strong interest in developmental genetics. Research currently includes: Developmental biology of the kidney and urinary tract, and associated diseases. Cell survival and developmental mechanisms in cancer and identification of therapeutic targets for cancer treatment. The use of developmental models to determine the regulation and function of genes involved in both development and disease including: RAD21/MYCN, cell growth and breast cancer; PAX genes, embryonic development and cancer; TES, blood development and leukaemia; polycystic kidney disease genes; cohesin proteins and Cornelia de Lange syndrome.

Chromosome structure and epigenetics The architecture of normal chromosome during the cell cycle, and the modification of genes by epigenetic marks can also contribute to changes gene expression, animal development and cancer. Foci of research include: exploring the functions of the chromosomal glue, cohesin, in its switching of gene activity; the role of epigenetic modification in the development and function of the placenta; epigenetic silencing as a mechanism of leukaemia gene silencing and as a marker for cancer.

Zebrafish as a model of human disease Groups both within and the outside the Department make extensive use of the Otago Zebrafish Facility that is directed by Dr Julia Horsfield. Since there is high conservation of developmental genes throughout evolution, zebrafish provide an amenable vertebrate animal model. Zebrafish are being used to determine the function of cohesin, testin, YB-1 and many other proteins important in developmental disorders and cancer.

Website: www.otago.ac.nz/zebrafish

Genetics of human disease Several of the Department’s researchers have expertise in the discovery of the genetic contribution to human disease, such as genetic influences on bipolar disorder, gene mutations in polycystic disease, mutations in congenital malformation syndromes, and mutations in familial and acquired cancer.

Division of HEALTH SCIENCES 59 External Grants > $50,000 Awarded 2009-2010

Year PI Project Title Funder $ Approved* Approved

2010 Prof Antony Can isoforms of the p53 tumour suppressor Health Research 1,158,492 Braithwaite cause cancer? Council of NZ

2010 Dr Sarah Young The use of virus-like particles as vaccines and Health Research 391,707 therapies against cancer Council of NZ DSM 2010 Dr Julia Horsfield Oestrogen-dependent regulation of gene Health Research 275,444 expression by cohesin in breast cancer Council of NZ/A *STAR

2010 Prof Ian Morison Epigenomics of liver tumour induction and Health Research 253,849 progression: use of a zebrafish model Council of NZ/A *STAR

2010 Prof Antony YB-1 interacting partners in breast cancer Health Research 223,794 Braithwaite progression Council of NZ/A *STAR 2010 Dr Tania Slatter The role of p53 isoforms for increased cancer Health Research 150,000 susceptibility Council of NZ

2010 Dr Adele Woolley IncuCyte FLS Microscope System New Zealand Lottery 100,000 Grants Board

2010 Dr Julia Horsfield Oestrogen dependent regulation of gene Genesis Oncology 66,647 expression by cohesin in breast cancer Trust

2010 Dr Sarah Young The use of virus-like particles as vaccines and Genesis Oncology 45,454 therapies against cancer Trust

2009 Prof Ian Morison The epigenome of myelodysplastic syndrome Health Research 1,326,265 Council of NZ

2009 Prof Ian Morison TES: a terrific candidate gene for childhood Cancer Society 150,000 leukaemia of New Zealand

2009 Dr Aaron Jeffs Genome instability in melanoma New Zealand Lottery 116,328 Grants Board

2009 Prof Ian Morison Unravelling cancer genes in childhood Cure Kids 99,920 leukaemia: testing TES

2009 Dr Julia Horsfield A RADical view of cohesin function in New Zealand Lottery 95,866 human disease Grants Board

2009 Prof Ian Morison Enhanced multifunctional tissue processing New Zealand Lottery 50,598 Grants Board

*GST exclusive

Commercial Contracts

Year Approved Organisation

2009-10 Roche Products (NZ) Ltd

Total 190,000

60 RESEARCH REPORT 2009/2010 Postgraduate Students

Total Head Count 2009 2010

PhD 7 10

Masters† 6 6 † thesis or dissertation students only

Awards and Scholarships DSM

Year Researcher Award/Scholarship

2010 Dr Julia Horsfield Research Development Investment Award, DSM

DEPARTMENT OF PREVENTIVE AND SOCIAL MEDICINE

Head of Department: Professor Jennie Connor. Email: [email protected]

The Department of Preventive and Social Medicine constitutes one of the leading centres for public health research in Australasia. There are a number of major research groups within the Department including: the Injury Prevention Research Unit (IPRU), the Dunedin Multidisciplinary Health and Development Research Unit (DMHDRU), the Hugh Adam Cancer Epidemiology Unit (HACEU), the Ngäi Tahu Māori Health Research Unit, the AIDS Epidemiology Group, the Cancer Society Social and Behavioural Research Unit (SBRU), the Centre for International Health, and the Centre for Health Systems. The New Zealand Pharmacovigilance Centre (NZPC), and the National Poisons Centre (NPC) are also housed in the Department.

Website: www.otago.ac.nz/dsm/psm

Major Areas of Research Strength

Lifecourse research The Dunedin Multidisciplinary Health and Development Research Unit (DMHDRU) conducts the Dunedin longitudinal study, one of the most detailed studies of human health and development ever undertaken. A multidisciplinary, longitudinal study of 1,037 babies born in Dunedin during 1972/73, the Study members have been followed up since birth, at age three, then every two years to age 15, and at ages 18, 21, 26, and 32. Age 38 assessments were undertaken in 2010. For each follow-up phase, the Study members are brought to the Dunedin Unit where they undergo numerous assessments and measures of their health and development. The main research focus is human development over the lifecourse. Other studies run by DMHDRU include those of the parents of the original Study Members (Family Health History Study), parenting behaviours of Study Members (Parenting Study), and the 15-year-old children of Study Members (Dunedin Next Generation Study). The research will provide ground-breaking information across three generations of New Zealand families. Knowledge gleaned from the Study has influenced family, child and public health policies and practice nationally and internationally.

The Dunedin Multidisciplinary Health and Development Research Unit is also a founding partner in the National Centre for Lifecourse Research (http://www.lifecourse.ac.nz/home)

Website: http://dunedinstudy.otago.ac.nz/

Injury Prevention The goal of Injury Prevention Research Unit (IPRU) is to undertake research that will contribute to reducing the incidence, severity, and consequences of injury in New Zealand. The Unit’s staff work in a wide range of research areas such as unintentional and intentional injury, outcomes of injury, and injury prevention. Studies may be based on settings where injury occurs, such as in transport, sport and recreation and work, or on groups within the population who are at risk, such as children, young people, or older people. Injury surveillance, examination of cross cutting issues such as alcohol misuse, and the consequences of injury both disability and rehabilitation are also examined.

Website: www.otago.ac.nz/ipru/

Division of HEALTH SCIENCES 61 Cancer The Department has significant expertise in cancer research, with two research Centres dedicated to this field: the Hugh Adam Cancer Epidemiology Unit (HACEU) and the Cancer Society Social and Behavioural Research Unit (SBRU).

The focus of cancer epidemiology research of the department is the HACEU. The Unit is involved in several national and international studies of the prevention, causes, impact, burden and consequences of cancer as well as assessments of cancer incidence, mortality and survival in New Zealand. Recent research includes a nationwide study of prostate cancer, a national study of bowel cancer, and an investigation into the delay in the diagnosis of cancer in Pacific Island men.

The SBRU is the focus of research into social and behavioural aspects of cancer. To date, it has worked mainly in the priority

DSM areas identified for the primary prevention of cancer in New Zealand, that is tobacco control, healthy physical activity and nutrition, and ultraviolet radiation exposure. Studies also focus on the psycho-social-spiritual aspects of cancer and cancer control and health promotion.

Website: www.otago.ac.nz/sbrcg

International health The Centre for International Health is based in the Department. The Centre aims to make a significant contribution to the understanding, development and well-being of individuals and populations in developing countries. Research projects and collaborations are underway with other institutes in the Gambia, Indonesia, Samoa and Cambodia.

Website : http://dnmeds.otago.ac.nz/departments/psm/research/international_hlth/index.html

Hauora Mäori Rangahau hauora Mäori (Mäori health research) is an important part of the research portfolio of the Department. The goal of the Ngäi Tahu Mäori Health Research Unit is to contribute to the body of knowledge on Mäori health that will lead to positive health outcomes for Mäori and their whänau. The Unit collects, collates, interprets and publishes information, data and statistics on Mäori health issues. The major research focuses for the Unit are: hauora rangatahi (young people’s health); hauora wahine (Mäori women’s health), Mäori and mental health, oranga niho (dental health) and Mäori and injury prevention.

AIDS epidemiology The AIDS Epidemiology Group has been responsible for national surveillance of AIDS and HIV infection in New Zealand since 1989. The aims of the Group are to monitor the epidemic of HIV/AIDS in New Zealand through ongoing surveillance; to develop, and when appropriate to apply, new methods of monitoring and evaluation; and to contribute to the wider knowledge of HIV infection and AIDS.

Health systems The Centre for Health Systems facilitates and promotes research into health system improvement at the University of Otago, and across the local and national health systems, as well as internationally. The Centre’s associates come from a range of University of Otago departments including those spanning our three campuses in Dunedin, Christchurch and Wellington, as well as the School of Business. It works closely with the Southern DHB and has links with a range of national and international research groups including the Commonwealth Fund, Boston University Health Policy Institute, and London School of Economics (Health and Social Care).

Other research The Department of Preventive and Social Medicine is a research-intensive department and has a number of other areas of research strength including: poisons research; pharmacovigilance; environmental health; epidemiology of infectious diseases; health policy and economics; occupational health; and alcohol-related harm.

External Grants > $50,000 Awarded 2009-2010

Year PI Project Title Funder $ Approved Approved*

2010 Dr Dorothy Begg Preventing injury and reducing subsequent Health Research 4,353,633 disability outcomes Council of NZ – Programme

2010 Dr Peter Saxton Estimating unrecognised HIV infection in a Health Research 149,999 community sample of homosexual men Council of NZ

62 RESEARCH REPORT 2009/2010 2010 Prof Philip Hill A randomised control trial comparing 9 months’ Canadian Institues 162,900 Isonizaid to 4 months’ Rimfampin for latent of Health Research tuberculosis infection (subcontract)

2010 Dr Patricia Priest Knowledge, attitudes and practices in Family Health Research 110,510 Planning for Fijian women living in Fiji and NZ Council of NZ

2010 Prof Philip Hill Infertility in Samoa and its relationship to New Zealand 50,000 chlamydial infection International Aid & Development Agency

DSM 2009 Prof Richie Poulton The Dunedin Multidisciplinary Study of aging Council of NZ – 4,568,389 and risk for chronic disease Programme

2009 Prof Richie Poulton Psychiatric and social predictors of poor Health Research 2,595,046 cardiovascular health Council of NZ

2009 A/P John Broughton Disease burden and health inequalities arising Health Research 2,352,328 from chronic dental disease in indigenous Council of NZ children

2009 A/P Nigel Dickson Sexual reproductive health at age 38 in the Health Research 967,816 Dunedin cohort Council of NZ

2009 A/P Colin Cryer NZIPS Case Definition Review Health Research 85,000 Council of NZ

2009 Dr Mary Jane Sneyd Development of a New Zealand-specific risk Genesis Oncology 65,993 assessment tool for melanoma Trust

2009 Dr Rebbecca Lilley Feasibility of a national study of worker’s Health Research 65,966 exposure to health and safety risks Council of NZ – Feasibility study

* GST exclusive

Commercial Contracts

Year Approved Organisation

2009-10 ACC Alcohol Advisory Council of New Zealand Auckland Uniservices Ltd Cancer Society ESR EuroQol Group Fonterra Ltd Foundation for Youth Development Mental Health Foundation of New Zealand Ministry of Health Otago Community Hospice Road Safety Trust The War Pensions Advisory Board University of Newcastle

Total 5,262,768

Division of HEALTH SCIENCES 63 Postgraduate Students

Total Head Count 2009 2010

PhD 18 16

Masters† 6 6 † thesis or dissertation students only

Awards and Scholarships DSM

Year Researcher Award/Scholarship

2010 Prof Richie Poulton Dame Joan Metge Medal, Royal Society of New Zealand

2010 Prof Richie Poulton Elected to Royal Society of New Zealand

2010 Dr Robin Gauld First Prize, Health and Social Care category, British Medical Association book awards for The New Health Policy

2010 Dr Sarah Derrett Fulbright-Harkness New Zealand Fellowship

2010 Dr Lianne Parkin Ig Nobel Physics Prize

2010 Dr Patricia Priest Ig Nobel Physics Prize

2010 Sheila Williams Ig Nobel Physics Prize

2009 Emma Wyeth Te Amorangi National Mäori Academic Excellence Award

DEPARTMENT OF PSYCHOLOGICAL MEDICINE

Head of Department: Professor Paul Glue. Email: [email protected]

The Department of Psychological Medicine consists of the two main units of Clinical Psychiatry and Behavioural Science. Both units are involved in a variety of clinically relevant research areas, with the main themes being mental health epidemiology, public health, and psychopharmacology. Specific research areas include including self-harm and suicide, substance misuse and addictions, primary care interventions, communication and consultation skills, cognitive processes, behavioural aspects of physical health, child abuse, exploration of developmentally appropriate techniques for gathering information from children, child therapies, creation of evidence-based reviews, psychopharmacology and development of novel therapeutics.

In 2010, Professor Paul Glue was a co-investigator on a $2.4 million dollar grant from FRST to assess the effect of Mullerian Inhibitory Substance on frailty.

Website: www.otago.ac.nz/dsm/psychmed

Postgraduate Students

Total Head Count 2009 2010

PhD 6 8

Masters† 4 1 † thesis or dissertation students only

64 RESEARCH REPORT 2009/2010 DEPARTMENT OF WOMEN’S AND CHILDREN’S HEALTH

Head of Department: Professor Barry Taylor. Email: [email protected]

The Department of Women’s and Children’s Health comprises the Section of Obstetrics and Gynaecology and the Section of Paediatrics.

The Section of Obstetrics and Gynaecology has a strong research focus, specifically, reproduction and infertility, urogynaecology, urinary incontinence, contraception, menopause, obesity and weight management in pregnancy, placental pathology and management of high-risk pregnancy. Staff members are involved with the Cochrane Incontinence Review Group. DSM Website: http://dnmeds.otago.ac.nz/departments/womens/obstetrics/index.html

Areas of particular research strength in the Section of Paediatrics include sudden infant death syndrome, asthma, sleep related breathing disorders, the National Mortality Review for Children, genetics of congenital malformations, and ethics and clinical genetics. The Department is also home to the New Zealand Paediatric Surveillance Unit.

Website: www.otago.ac.nz/dsm/wch

Major Areas of Research Strength

Clinical genetics Congenital birth defects affect one in every 30 children born in New Zealand and many aspects of their genesis remain a mystery. The prime thrust of clinical genetics research is the identification of the genetic determinants of congenital birth defects in children. Disorders under investigation include: the otopalatodigital syndrome spectrum disorders; the Larsen syndrome-atelosteogenesis spectrum; periventricular nodular heterotopia; osteopathia striata congenita; and De Barsy syndrome. In addition, the characterisation of new disease genes is a priority. The ethical consequences of the application of genetic information in the clinical arena are also of interest.

Website: www.otago.ac.nz/dsm/clinicalgeneticsgroup

Sleep related breathing disorders Research into breathing disorders during sleep evolved from a long interest in understanding normal and abnormal breathing during sleep in infancy (when the focus was on infants having apparent life threatening events). It has become increasingly clear that in both adults and children disordered sleep can affect daytime attention span and learning. Studies are currently looking at sleep and breathing in children with ADHD as there is a suggestion that up to 25% of these children may have disordered sleep breathing.

Childhood obesity Becoming overweight is one of the biggest threats to health in the twenty first century in many countries including New Zealand. Growth in early childhood sets the pattern for future growth. What babies eat, how they play and how well they sleep may all be important in how fast babies put on weight. The Prevention of Overweight in Infancy study is a three year Health Research Council funded study designed to work out whether extra information and support for families can improve eating and activity, encourage better sleep for babies and parents, reduce post-natal depression, improve a family’s well-being and reduces the rate of excessive weight gain during infancy.

Incontinence The Cochrane Incontinence Group provides a major focus for this research theme within the Department. The goal of the group is to prepare systematic reviews of the effectiveness of interventions for incontinence, including prevention, treatment and rehabilitation, concentrating on randomised controlled trials. Other incontinence research within the department falls within the framework of clinical rehabilitation, with a specific interest in the management of adult urinary incontinence. One recent project investigated the effectiveness of non-surgical treatments for women with stress incontinence. An additional project is a mixed methods study investigating women’s beliefs about bladder control and to what extent this might contribute to their views of treatment for urinary incontinence.

Division of HEALTH SCIENCES 65 External Grants > $50,000 Awarded 2009-2010

Year PI Project Title Funder $ Approved* Approved

2010 Prof Barry Taylor Safer sleeping environments: Evaluation of a new Health Research 1,199,740 option for New Zealand babies Council of NZ

2010 Prof Stephen Developing a genetic approach to enhance Cure Kids 103,400 Robertson bone healing

DSM 2009 Prof Stephen The two faces of WTX in human development Royal Society of 746,667 Robertson New Zealand Marsden

2009 Dr Pamela Jackson RV3 Rotovirus Vaccine: A Phase 2 clinical trial Health Research 459,000 for a human neonatal rotavirus vaccine for the Council of NZ – global community International Investment Opportunities Fund

2009 Prof Stephen Genomic and proteomic approaches to study Cure Kids 210,000 Robertson malformations in children

* GST exclusive

Commercial Contracts

Year Approved Organisation

2009-10 ACC Mid Central District Health Board Ministry of Health Paediatric Society of New Zealand Nelson Marlborough District Health Board Southern District Health Board Whanganui District Health Board

Total 2,592,099

Postgraduate Students

Total Head Count 2009 2010

PhD 5 7

Masters† 1 1 † thesis or dissertation students only

Awards and Scholarships

Year Researcher Award/Scholarship

2010 Prof Stephen Liley Medal, Health Research Council of New Zealand Robertson

2009 Prof Barry Taylor Montgomery Spencer Memorial Oration Award, Royal Australasian College of Physicians

66 RESEARCH REPORT 2009/2010 UNIVERSITY OF OTAGO, CHRISTCHURCH

DEPARTMENT OF ANAESTHESIA

Head of Department: Professor Edward Shipton. Email: [email protected]

The Department of Anaesthesia has a small but active research programme. Recent areas of interest include volatile anaesthetic uptake and distribution; acute and chronic pain, and model-based therapies.

Website: www.otago.ac.nz/christchurch/departments/anaesthesia/index.htm UOC Major Areas of Research Strength

Anaesthetic uptake and distribution The research is diversified, although realistically collaborative research assumes greater importance in a small Department. Part of the research has been on anaesthetic monitoring particularly with the predictive use of computer modelling. A computer programme has been developed to model volatile anaesthetic uptake and distribution. The relationship between calculated effect-site volatile anaesthetic levels and awakening from anaesthesia has been studied. The safe delivery of anaesthesia has also been examined in patients with mitochondrial myopathies and prolonged QT syndromes.

Pain An ongoing area of interest is persistent pain and its management. Research focuses on complex regional pain syndrome (CRPS), post surgical neuropathic pain and chronic pain. The predictors and risk factors in the development of persistent acute postoperative pain have been looked at as well. The psychosocial adjustment and physical health of children living with mothers with chronic pain has been explored. The role of parenting as a mediator has been probed. Novel methods of perioperative pain relief have been developed particularly in the paediatric population with the intranasal route and with the use of analgesic drops. The comparison of usual surgical advice versus a non-aggravating six-month gym-based exercise rehabilitation program post-lumbar discectomy with three years of accumulated data has been researched as well. Two ongoing studies are the effect of pre-emptive gabapentin on chronic neuropathic pain following inguinal hernia repair, and the efficacy and safety of bisphosphonates in CRPS.

Intensive Care There is collaboration of work on effect site concentrations of volatile and intravenous anaesthetic agents with bioengineering at Canterbury University. There is potential for feedback loops for target-controlled infusions to be tested in clinical anaesthesia and in pain medicine. There is active collaborative research in model-based therapeutics in the application of physiological modelling and computation. This occurs in the following areas, namely: Tight Glycaemic Control and Specialised Insulin and Nutrition Tables; Metabolic Markers of Critical Illness; Optimising Mechanical Ventilation; Cardiovascular Modelling; and Control Agitation Sensing and Optimising Sedation Delivery.

External Grants Awarded 2009-2010

Year PI Project Title Funder $ Approved* Approved

2010 Dr Geoffrey Shaw Realising the benefits of tight glycemic control FRST Top Achiever 275,000 in critical care Post-Doctoral Grant

2009 Dr Geoffrey Shaw Next generation monitoring and diagnostics FRST International 606,000 Investment Opportunities Fund

2009 Dr Geoffrey Shaw Next generation monitoring and diagnostics FRST (subcontract) 28,500

* GST exclusive

Postgraduate Students

Total Head Count 2009 2010

PhD 1 1

Masters† - 1 † thesis or dissertation students only

Division of HEALTH SCIENCES 67 DEPARTMENT OF MEDICINE

Head of Department: Associate Professor Lutz Beckert. Email: [email protected]

The Department of Medicine has diverse research interests and hosts a number of very productive research groups. Areas of research include cardioendocrinology, respiratory research, renal disease, clinical pharmacology, neurology, rheumatology; and healthcare of the elderly.

Website: www.otago.ac.nz/christchurch/departments/medicine/index.html

UOC Major Areas of Research Strength

Cardioendocrine research Cardioendocrine research is undertaken by members of the Christchurch Cardioendocrine Research Group (CCERG). Research is aimed at defining those plasma neurohormonal measurements, cardiac imaging features, and genotypes which provide the best diagnostic, prognostic and therapeutic potential for detection and management of heart failure. The Group is also involved in a community heart study to assess the proportion of Māori living with undiagnosed heart disease, diabetes, hypertension, high cholesterol or other significant cardiovascular disease risk factors. The work of the CCERG has provided a large bank of practical knowledge that is used by cardiologists to monitor the prognosis and treatment of patients who have suffered heart attacks. The Group’s world leading research on natriuretic peptides has contributed to several clinical trials on their use.

Website: www.otago.ac.nz/christchurch/research/cardioendocrine/index.html

Kidney disease Research is directed towards investigating innovative ways to prevent and treat kidney disease. Expertise ranges from molecular and cellular-level investigations of kidney function, to applying therapies to prevent kidney injury or the progression of kidney disease. The aim is to better understand the mechanisms of insult to the kidney, so as to allow earlier detection and better treatment. Efforts are underway to find new markers for early acute renal failure so it can be treated before irreversible damage or death occurs. Current research projects include: pathophysiology and early detection of acute renal failure; roles of apoptosis, growth factors, cell survival genes, nitric oxide and free radicals in acute renal failure; clinical renal trials, and progression of renal disease.

Clinical pharmacology The clinical application of pharmacology knowledge is the focus of the Clinical Pharmacology Research Group. This Group includes staff from the Clinical Pharmacology Department at Christchurch Hospital, the Drug Information Service and the Drug Utilisation Review Service. Current research interests include: pharmacogenetics; drug metabolism in the elderly; drug use in pregnancy and lactation; antibiotic dosing regimens – especially for the aminoglycosides; phase III drug trials of gastroenterology drugs; provision of drug information; adverse drug reactions; and thiopurine drugs.

Website: www.otago.ac.nz/christchurch/research/clinicalpharmacology/index.html

External Grants > $50,000 Awarded 2009-2010

Year PI Project Title Funder $ Approved* Approved

2010 A/P Chris Charles Sympathoinhibitory hormone Urocortin 2: Health Research 1,057,693 Beneficial effects in cardiac injury? Council of NZ

2010 Dr Anna Pilbrow Blood relations: finding circulating biomarkers Health Research 500,000 for inherited heart disease Council of NZ – Sir Charles Hercus Research Fellowship

2010 Dr John Pickering Critically ill with a failing kidney: How can we Marsden – Faststart 306,666 predict what happens next?

2010 Dr Jeffrey Ngu Autoimmune liver diseases in NZ Population- Health Research 250,000 based epidemiology, genetics and therapeutics Council of NZ

2010 Dr Wandy Chan Novel Management and Monitoring of Heart National Heart 240,000 Failure Foundation of NZ

2010 Dr Toni Pitcher Magnetic Resonance Imaging of Anxiety in Neurological Parkinson’s 179,899 Disease Foundation of New Zealand

68 RESEARCH REPORT 2009/2010

2010 A/P Richard Troughton The PEOPLE Study National Heart 163,016 Foundation of NZ

2010 Dr Maithri Siriwardena NHF Clinical Research Fellowship National Heart 160,000 Foundation of NZ

2010 Dr Lisa Stamp Effect of vitamin C on serum urate in patients Health Research 149,780 with gout Council of NZ

2010 Dr Leigh Ellmers Uroguanylin: Prognostic/therapeutic potential National Heart 148,962 UOC in cardiovascular disease Foundation of NZ

2010 Dr Barry Palmer The VEGF system and survival in heart patients National Heart 140,864 Foundation of NZ

2010 Dr Lisa Stamp Folate supplementation in RA patients Arthritis 97,294 receiving methotrexate – are we impairing New Zealand the efficacy of MTX?

2010 A/P Richard Gearry Evaluation of novel biomarkers in inflammatory Canterbury Medical 86,615 bowel disease (IBD) Research Foundation

2010 Dr Anthony Rahman Venous thromboembolism in cancer patients The Royal Australasian 60,000 treated with chemotherapy College of Physicians

2009 Dr Tim Prickett Studies on the cardio-protective effects of Health Research 646,169 CNP agonists Council of NZ

2009 Dr Chris Pemberton Sending a signal? Ghrelin peptides in acute Health Research 643,363 cardiac ischemia Council of NZ

2009 A/P Miriam Rademaker Implantable devices: Improved monitoring of Health Research 589,776 heart failure and tacharrythmia Council of NZ

2009 Dr Nicola Scott Metabolic syndrome: from mice to men Health Research 147,220 Council of NZ

2009 Dr Katrina Ellis Circulating biomarkers for risk profiling of New Zealand Lottery 97,417 cardiovascular disease Grants Board

2009 Dr Anna Pilbrow Molecular mechanisms underlying genetic New Zealand Lottery 95,260 susceptibility for heart disease Grants Board

2009 Dr Leigh Ellmers Effect of chronic Urocortin-2 treatment after National Heart 92,595 experimental myocardial infarction Foundation of NZ

2009 Dr Sally Aldous Cardiac markers in acute coronary syndromes National Heart 80,000 Foundation of NZ

2009 Dr Leigh Ellmers The role of superfoods on the development National Heart 78,000 and management of the metabolic syndrome Foundation of NZ

2009 Dr Steadman Autoimmune liver disease in Canterbury Canterbury Medical 77,500 Research Foundation

2009 Dr Michael MacAskill Can advanced MRI and saccade parameters Canterbury Medical 74,350 faithfully measure progression in Parkinson’s Research Foundation disease?

2009 Dr Toni Pitcher Biomarkers of Parkinson’s disease New Zealand Lottery 72,165 Grants Board

* GST exclusive

Division of HEALTH SCIENCES 69 Commercial Contracts

Year Approved Organisation

2009-10 Alere Inc Critical Care Diagnostics George Clinical Pty Ltd New Zealand Pharmaceuticals Ltd Quintiles Pty Ltd

UOC Total 1,116,645

Postgraduate Students

Total Head Count 2009 2010

PhD 17 21

Masters† 2 5 † thesis or dissertation students only

Awards and Scholarships

Year Researcher Award/Scholarship

2010 A/P Richard Gearry University of Otago Early Career Award for Distinction in Research

2010 Dr Anna Pilbrow Sir Charles Hercus Research Fellowship, Health Research Council of New Zealand

2010 Tracey Melzer Health Sciences Career Development Postdoctoral Fellowship (PhD student)

2010 Michael Annear University of Otago Prestigious PhD Scholarship (PhD student)

2009 A/P Bridget Robinson Companion of the Queen’s Service Order (QSO) for services to medicine

2009 Dr Lisa Stamp University of Otago Early Career Award for Distinction in Research

70 RESEARCH REPORT 2009/2010 DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY

Head of Department: Associate Professor Peter Sykes. Email: [email protected]

The Department of Obstetrics and Gynaecology has a number of established research projects in progress which are funded from a variety of sources. The main themes are gynaecological cancer; reproductive steroids in cardiovascular disease; endocrine regulation of reproduction; and maternal and fetal medicine.

Staff are members of a number of advisory bodies, serve on a variety of grant assessing committees including the HRC, are guest editors of international journals, present invited talks at international conferences and peer review journal submissions and grant applications. UOC

Website: www.otago.ac.nz/christchurch/departments/obgyn/index.html

Major Areas of Research Strength

Gynaecological cancer and precancer The department is closely affiliated with the regional gynaecological cancer service as well as local colposcopy and pathology services. Such collaborative links permit bench to bedside research. The department takes part in, and leads, international multicentre clinical trials, local clinical trials, retrospective clinical studies and commercial research.

Cell and protein regulation The Laboratory for Cell and Protein Regulation is interested in characterising the communities of chemical factors that make up physiological systems and to describe the dynamic interactions that occur. The main research themes are gynaecological cancers, endocrine regulation of reproduction, female fertility, and assessment of fetal welfare. The research is undertaken in collaboration with other scientists both locally and internationally in basic science and clinical areas. There have been long- standing interactions with the Schools of Biological Sciences and Engineering at the University of Canterbury. The latter has matured to the level where we were awarded a Marsden Grant in the last round.

Website: www.otago.ac.nz/christchurch/research/cellproteinregulation/index.html

Maternal and fetal medicine Research covers both maternal and fetal health and outcomes. One area of research interest is database development. Ongoing data is collected for the (i) Fetal Medicine Clinical Unit which reviews women with complicated fetal problems or those at risk for them, and the (ii) Maternal Medical Clinic where women with underlying medical problems attend. This enables both audit and follow up of specific cases. Investigations into preeclampsia are underway. These focus on prediction of outcome (for mother and neonate), and assessment of proteinuria as a screening/diagnostic test. Researchers also participate in a variety of multicentre clinical trials.

Website: www.otago.ac.nz/christchurch/research/maternalfetalhealth/index.html

External Grants > $10,000 Awarded 2009-2010

Year PI Project Title Funder $ Approved* Approved

2010 A/P John Evans Intersection of nanoscience and biology MacDiarmid Institute 43,625

2010 A/P Peter Sykes Can dietary supplementation augment Robert McLelland Trust 22,195 anti-angiogenic therapy in ovarian cancer?

2010 A/P Peter Sykes Two years partial funding for a Gynaecology Genesis Oncology Trust 17,504 Cancer Research Nurse

2010 A/P Peter Sykes A prospective audit of sentinel node biopsy of Robert McClelland Trust 11,782 vulval carcinoma in Australia and New Zealand

2009 Dr Ruth Hughes Control of hypertension in pregnancy study: Canadian Institutes 68,468 CHIPS of Health Research (subcontract)

2009 A/P Peter Sykes Characterising specific cell compartments of Maurice and Phyllis 20,000 the fertile endometrium by gene and protein Paykel Trust expression

* GST exclusive

Division of HEALTH SCIENCES 71 Commercial Contracts

Year Approved Organisation

2009-10 Canterbury District Health Board GlaxoSmithKline, Australia University of Canterbury

Total 553,910 UOC Postgraduate Students

Total Head Count 2009 2010

PhD 2 2

Masters† - - † thesis or dissertation students only

Awards and Scholarships

Year Researcher Award/Scholarship

2010 Dr Mary Olliver Outstanding Teaching Award, University of Otago, Christchurch

DEPARTMENT OF ORTHOPAEDIC SURGERY AND MUSCULOSKELETAL MEDICINE

Head of Department: Associate Professor Gary Hooper. Email: [email protected]

The Department of Orthopaedic Surgery and Musculoskeletal Medicine is unique in New Zealand in that both the Academic and Service Departments are combined so that the surgical and medical components of musculoskeletal diseases and injuries come under the roof of one department.

Website: www.otago.ac.nz/christchurch/departments/orthomsm/index.html

Major Areas of Research Strength

Tissue engineering Tissue engineering strategies which aim to combine a patient’s own cells, biodegradable scaffolds and growth factors may offer considerable advantages over current surgical interventions used to repair or regenerate damaged tissues following trauma or disease. This is the focus of the Christchurch Regenerative Medicine and Tissue Engineering Group (CReATE). Areas of particular research interest include: orthopaedic biomechanics - total joint replacement and medical device design; tissue engineering and regeneration of cartilage, bone and neural/spinal cord; advanced scaffold design and bio-manufacturing; biomaterials engineering; dynamic mechanical analysis of porous materials; and novel metal alloys for bone interfacing implants.

Prospective clinical outcome studies Studies underway are mainly long term prospective outcome studies on various types of total joint replacements. In addition the department is responsible for the National Joint Replacement Register. The Register was established by the New Zealand Orthopaedic Association to record technical information about total hip and knee surgery performed in New Zealand. As of September 2004 there are now over 52,000 procedures registered. These include primary and revision hips, knees, ankles, elbows and shoulders.

Reconstructive upper limb surgery for tetraplegia Reconstructive surgery for tetraplegia has been carried out at the Spinal Injuries Unit at Burwood Hospital since 1982. The Unit is now one of the leaders in the world, not only for the surgery itself but also for outcome studies including the development of new surgical procedures. An active research programme includes studies into: changes in tendon length during postsurgical rehabilitation; development of a device for accurate measurement of joint torque; patterns of shoulder motion; and wheelchair kinematics.

72 RESEARCH REPORT 2009/2010 External Grants > $10,000 Awarded 2009-2010

Year PI Project Title Funder $ Approved* Approved

2009 Dr Geoff Rodgers Acoustic emission monitoring following total FRST – Postdoctoral 265,168 joint replacement surgery Fellowship

2009 Dr Tim Woodfield Alternative cartilage engineering strategies AO Foundation 157,480

UOC 2009 Dr Tim Woodfield Cartilage Tissue Engineering: Better Tissues New Zealand Lottery 73,258 with Smarter Scaffolds Grants Board

2009 Dr Tim Woodfield Cartilage tissue engineering via smarter scaffolds Wishbone Trust of NZ 30,000

* GST exclusive

Postgraduate Students

Total Head Count 2009 2010

PhD - 2

Masters† 1 - † thesis or dissertation students only

Awards and Scholarships

Year Researcher Award/Scholarship

2010 Dr Iain Bell Barrie Tait Prize for Academic Achievement (PGDipMSM student)

2010 Dr Tin Chak Hong Barrie Tait Prize for Clinical Excellence (PGDipMSM student)

Dr Tim Woodfield specialises in tissue engineering and regenerative medicine and is attempting to find a solution to regenerating human knee cartilage

Division of HEALTH SCIENCES 73 DEPARTMENT OF PAEDIATRICS

Head of Department: Associate Professor Andrew Day. Email: [email protected]

The Department of Paediatrics has an active research programme. Long-established research interests include paediatric urology especially reflux, community child health, sudden infant death syndrome, and neonatal research. More recently the Department has developed research interests in free radicals, respiratory medicine, gastroenterology and cancer genetics.

Website: www.otago.ac.nz/christchurch/departments/paediatrics/index.html

UOC Major Areas of Research Strength

Neonatology The Cure Kids Chair in Paediatric Research is held in the Department by Professor Brian Darlow. Research interests concern the care of newborn, sick and premature babies, including trying to identify the causes of health problems associated with premature birth and ways to prevent them. Follow-up studies of the health outcomes of extremely premature infants are also carried out. A specific interest is free radical disease in the newborn.

Childhood cancer The Children’s Cancer Research Group is working on a variety of projects, from the basic biology of cancer in children, to the complex long-term effects of its treatment. Researchers are interested in the biology and genetics of childhood solid tumours. Current projects involve investigating the molecular genetics of neuroblastomas and hepatoblastomas using microarray gene expression technology, tissue arrays and protein analysis. More specifically, projects are underway to investigate the role of histone methylation and DNA methylation in both neuroblastoma and hepatoblastoma, and the role of the sonic hedgehog developmental pathway in paediatric solid tumours.

Website: www.otago.ac.nz/christchurch/research/childrenscancer/index.html

Gastrointestinal disorders A new focus is being developed on host:pathogen interactions within the gastrointestinal tract, with particular emphasis on inflammatory bowel syndrome (IBD) and Crohn’s disease.

External Grants > $10,000 Awarded 2009-2010

Year PI Project Title Funder $ Approved* Approved

2010 Dr Jody Porter Gastrointestinal manifestations of type one Freemasons Grand 57,648 diabetes in children Lodge of New Zealand

2009 A/P Andrew Day Epithelial defensins in inflammatory bowel disease Canterbury Medical 62,756 Research Foundation

* GST exclusive

Postgraduate Students

Total Head Count 2009 2010

PhD 1 2

Masters† - 1 † thesis or dissertation students only

Awards and Scholarships

Year Researcher Award/Scholarship

2010 Prof Brian Darlow Gold Medal for excellence in research, UOC

74 RESEARCH REPORT 2009/2010 DEPARTMENT OF PATHOLOGY

Head of Department: Professor David Murdoch. Email: [email protected]

The Department of Pathology is one of the largest and most research intensive departments at the University of Otago, Christchurch. Research groups within the Department include: the Free Radical Research Group (FRRG); the Cancer Genetics Research Group; the Gene Structure and Function Laboratory; the Angiogenesis and Cancer Research Group (ACRG); the Christchurch Haematology Research Group; the Inflammation Research Group, the Liver Sieve Research Group; the Christchurch Microbiology Research Group; and the Breath Research Group. The Department also hosts the Carney Centre for Pharmacogenetics. UOC Website: www.otago.ac.nz/christchurch/departments/pathology/index.html

Major Areas of Research Strength

Free radical research Free radical research, carried out in the Free Radical Research Group (FRRG) is one of the Department’s major research interests. The FRRG consists of biochemists and cell biologists undertaking a range of interrelated research projects on aspects of oxidative stress and antioxidant action. Current areas of research include: oxidant production by neutrophils, with emphasis on the enzymology of myeloperoxidase; the molecular and cellular reactions of the neutrophil oxidant, hypochlorous acid; mechanisms and consequences of thiol protein oxidation; redox regulation of cell signaling; oxidative stress and apoptosis; radical scavenging mechanisms and reactions of superoxide radicals. The group has an active programme of developing biomarker assays for specific oxidants and applying them to investigating oxidative injury in disease. Collaborative clinical projects include investigations of the role of oxidants in lung disease and brain injury in premature infants, cystic fibrosis, inflammatory conditions such as asthma, gout and sepsis; and gastrointestinal diseases.

Website: www.otago.ac.nz/christchurch/research/freeradical/index.html

Cancer research Cancer research in the Department is undertaken by two groups.

The Cancer Genetics Research Group: the focus of research is the cytogenetic and molecular genetic basis of human cancer. The aims of the Group are to: identify new gene alterations which are relevant to the cause and/or progression of cancer; to develop a better understanding of the molecular mechanisms that determine gene rearrangements in cancer cells; and to actively translate current research knowledge in these fields to clinical diagnosis.

Website: www.otago.ac.nz/christchurch/research/cancergenetics/index.html

The Angiogenesis and Cancer Research Group: this Group is investigating the biology of human tumours with a focus on the molecular regulation of blood (angiogenesis) and lymphatic vessel formation (lymphangiogenesis) and function during human tumour growth and metastasis. Specific research interests include: expression and regulation of angiogenic factors in human cancers; effects of the tumour microenvironment on tumour angiogenesis; targeting tumour endothelium; links between cancer, inflammation, and thrombosis; ethnicity and cancer biology; metabolism, insulin resistance and chronic low- grade inflammation in cancer biology; and skin cancers in immune-suppressed renal transplant recipients.

Website: www.otago.ac.nz/christchurch/research/acrg/index.html

Gene structure and function Much of the current research centres on the areas of psychiatric genetics and pharmacogenetics (the impact of genetic variation on responses to drugs) and is carried out within the Gene Structure and Function Laboratory. The laboratory’s psychiatric genetics research is a collaboration with Professor Peter Joyce in the Department of Psychological Medicine. Expertise includes gene structure and expression analysis, polymorphism detection (via DHPLC), development and application of genotyping assays, tissue culture including the manipulation of mouse embryonic stem cells, proteomics, microarray analysis, and rodent genetics.

Website: www.otago.ac.nz/christchurch/research/genestructure/index.html

Inflammation The Inflammation Research Group has an active research programme on the molecular pharmacology and molecular pathology of various inflammatory conditions such as acute pancreatitis, polymicrobial sepsis and burns with the long-term goal of developing clinically effective therapeutic approaches.

Website: www.otago.ac.nz/christchurch/research/inflammation/

Division of HEALTH SCIENCES 75 Infection Infectious diseases research is carried out by several clinicians and scientists within the department, and is based both locally and overseas. Current interests include the epidemiology and microbiology of respiratory tract and bloodstream infections, the role of vitamin D in infection, and the development of new diagnostics for infectious diseases. The latter includes analysis of potential biomarkers in breath.

External Grants > $50,000 Awarded 2009-2010

Year PI Project Title Funder $ Approved* Approved UOC 2010 Prof Steve Chambers Clinical trial of a novel breath test for biomarkers Health Research 593,993 of pulmonary tuberculosis Council of NZ

2010 Dr Peter Nagy Roles of hydrogen sulfide in inflammation Health Research 150,000 Council of NZ

2010 Prof Martin Kennedy The CHALICE Project: Shared equipment for New Zealand Lottery 105,500 sample biobanking Grants Board

2010 Dr Sarah Gunningham Ang-1/IL-29 as markers of cancer in patients with New Zealand Lottery 85,500 venous thromboembolism Grants Board

2010 Prof Christine Tuning within cardiac excitation-contraction National Research 96,000 Winterbourn coupling and nitrosative/oxidative effects Centre for Growth and Development

2010 Dr Amy Scott-Thomas Improving the 2-AA breath test for Ps. New Zealand Lottery 72,000 aeruginosa detection Grants Board

2010 Prof Madhav Bhatia Hydrogen sulfide in acute pancreatitis : A novel New Zealand Lottery 58,500 mediator of inflammation Grants Board

2010 Dr Logan Walker Role of germ-line DNA copy number variants in New Zealand Lottery 58,500 breast cancer risk and development Grants Board

2010 Dr Gabi Dachs Chemotherapy response in an obese mouse Canterbury Medical 56,922 model with colorectal cancer Research Foundation

2009 Prof Christine Oxidative stress in health and disease Health Research 2,215,010 Winterbourn Council of NZ

2009 Prof David Murdoch Effect of vitamin D supplementation on upper Health Research 1,719,632 respiratory infections in adults Council of NZ

2009 A/P Christine Morris Navigating structural complexity in the human Cancer Society of 200,210 leukaemia genome New Zealand

2009 Prof Christine Tuning with cardiac excitation-contraction National Research 96,000 Winterbourn coupling and nitrosative/oxidative effects Centre for Growth and Development

2009 Dr Margreet Vissers Effective vitamin C delivery to tissues by dietary Zespri Group Ltd 81,900 intervention with kiwifruit

2009 Dr Amy Scott-Thomas The development of a non-invasive breath test Child Health Research 75,665 to detect Pseudomona aeruginosa infections in Foundation children suffering from cystic fibrosis

2009 Prof David Murdoch PERCH (Pneumonia etiology research for child Bill and Melinda Gates 75,306 health) Foundation (subcontract)

2009 Dr Gabi Dachs Chemotherapy response in an obese mouse Genesis Oncology Trust 54,349 model with colorectal cancer

2009 Dr Margreet Vissers The effect of hypoxia and vitamin C deficiency Canterbury Medical 52,748 on immune cell function Research Foundation

* GST exclusive 76 RESEARCH REPORT 2009/2010 Commercial Contracts

Year Approved Organisation

2009-10 BioCell Corporation Ltd Syft Ltd Zespri International Ltd

Total 1,230,501 UOC Postgraduate Students

Total Head Count 2009 2010

PhD 16 12

Masters† 3 2 † thesis or dissertation students only

Awards and Scholarships

Year Researcher Award/Scholarship

2010 Professor Steve Chambers Gold Medal for excellence in research, UOC

2010 Dr Margreet Vissers Gold Medal for excellence in research, UOC

2009 A/P Bridget Robinson Companion of the Queen’s Service Order (QSO) for services to medicine

DEPARTMENT OF PSYCHOLOGICAL MEDICINE

Head of Department: Professor Roger Mulder. Email: [email protected]

The Department of Psychological Medicine is one of the largest Departments at the University of Otago, Christchurch and has a very active research programme. The Department hosts a number of research groups including: the Christchurch Health and Development Study (CHDS); The Canterbury Suicide Project; The Mental Health Clinical Research Unit (MHCRU); and The National Addiction Centre (NAC).

Website: www.otago.ac.nz/christchurch/departments/psychmed/

Major Areas of Research Strength

Lifecourse research The Christchurch Health and Development Study (CHDS) has been in existence for more thirty years. During this time it has followed the health, education and life progress of a group of 1,265 children born in the Christchurch urban region during mid 1977. This cohort has now been studied from infancy into childhood, adolescence and adulthood. Research projects in this study span a wide range of disciplines including psychology, psychiatry, epidemiology, paediatrics, health economics and sociology.

Website: www.otago.ac.nz/christchurch/research/healthdevelopment/index.html

Mental health research The Mental Health Clinical Research Unit (MHCRU) is involved in studies on depression, bipolar affective disorder, bulimia nervosa, anorexia nervosa, and the psychological effects of the Christchurch earthquakes. Current studies include a psychotherapy treatment trial in depression, a psychotherapy trial in people with bipolar disorder, a comparison of three psychotherapies for binge eating, and a study on the genetics of depression and personality.

Website: www.otago.ac.nz/christchurch/research/mentalhealthclinicalresearch/index.html

Division of HEALTH SCIENCES 77 Addiction research The National Addiction Centre (NAC) is dedicated to developing and promoting effective interventions for people with alcohol, drug and addiction related problems in Aotearoa New Zealand. Ongoing research projects include: ZonnicTM and Patch (ZAP) Smoking Cessation Study; Treatment Evaluation of Alcohol and Mood (TEAM) Study; Moana House Evaluation Project; Youth Retention Study; Odyssey Youth Outcome Study; The Effectiveness of Naltrexone in Reducing the Craving of People with Pathological Gambling; Resilience in Indigenous Health Networks; Development of Māori AOD Services and Workforce in Aotearoa New Zealand.

Website: www.otago.ac.nz/nationaladdictioncentre/

UOC External Grants > $10,000 Awarded 2009-2010

Year PI Project Title Funder $ Approved* Approved

2010 Dr Joseph Boden Alcohol and antisocial behaviour: Findings in Health Research 868,766 two birth cohorts Council of NZ

2010 Dr Maree Inder Patient perceptions of factors influencing Canterbury Medical 99,943 medication non-adherence in bipolar disorder Research Foundation

2010 Jennifer Reid Sick to death: Mäori access to quality health care Health Research 78,550 in Christchurch Council of NZ

2010 Prof Doug Sellman Abstinence in the treatment of obesity New Zealand Lottery 67,500 Grants Board

2010 Dr David Carlyle A clinical trial of mentalization based New Zealand Lottery 37,500 psychotherapy for the treatment of borderline Grants Board personality disorder

2009 Dr Virginia McIntosh Psychotherapeutic factors and outcome of New Zealand Lottery 85,700 anorexia nervosa Grants Board

2009 Dr Sheree Gibb TXT Rx: A pilot study of SMS messaging for Canterbury Medical 54,613 suicide prevention Research Foundation

2009 Dr Ria Schroder Abstinence vs moderation in Obesity Treatment: National Heart 14,500 Client perceptions of what works Foundation

* GST exclusive

Postgraduate Students

Total Head Count 2009 2010

PhD 9 11

Masters† 6 9 † thesis or dissertation students only

Awards and Scholarships

Year Researcher Award/Scholarship

2010 Professor David Fergusson Distinguished Research Medal, University of Otago

2010 Professor Roger Mulder Gold Medal for Excellence in Research, University of Otago

2010 Dr Lois Surgenor Genesis Oncology Professional Development Grant

78 RESEARCH REPORT 2009/2010 DEPARTMENT OF PUBLIC HEALTH AND GENERAL PRACTICE

Head of Department: Professor Les Toop. Email: [email protected]

The joint department is unique in New Zealand in that it brings together Public Health and General Practice/Primary Care teaching and research groups.

Website: www.otago.ac.nz/christchurch/departments/phgp/index.html

Major Areas of Research Strength UOC General practice research The Christchurch General Practice Research Group is involved in research into many areas of primary health care in New Zealand. The Group focuses on clinical research, where the results can be directly translated into clinical practice. The two central research themes underpinning this are rational use of medicines and innovative models of primary care.

Website: www.otago.ac.nz/christchurch/research/generalpractice/index.html

Public health research Public health is the study and practice of preventing disease, prolonging life and promoting the health of the population through the organised efforts of society. Research by the Public Health Research Group is carried out in the following areas: epidemiology, including colorectal cancer control in New Zealand; influenza; health services; health policy; health determinants; and methodological advances.

Website: www.otago.ac.nz/christchurch/research/publichealth/index.html

External Grants Awarded 2009-2010

Year PI Project Title Funder $ Approved* Approved

2009 Dr Phil Hider Improving health systems performance University of 568,654 enhancing hospital outcomes Auckland

2009 Dr Claire Dowson Cognitive and behavioural functioning with Canterbury Medical 66,206 long term antidepressant use Research Foundation

* GST exclusive

Postgraduate Students

Total Head Count 2009 2010

PhD 7 5

Masters† 7 12 † thesis or dissertation students only

Awards and Scholarships

Year Researcher Award/Scholarship

2009 Dr Ian Sheerin Fullbright Travel Award

2009 Dr Cheryl Brunton Named the Public Health Champion for 2009 by the Public Health Association of New Zealand

Division of HEALTH SCIENCES 79 DEPARTMENT OF RADIOLOGY

Head of Department: Professor Tim Buckenham. Email: [email protected]

The Department of Radiology has a small but active research programme. Recent research projects include: the development of a national thoracic aortic stent database to collect and assess data from all implants performed in New Zealand; the development of new detectors that have applications in medical imaging; and bioengineering and nanomedicine.

Website: www.chmeds.ac.nz/departments/radiology/index.htm

UOC Major Areas of Research Strength

Bioengineering and nanomedicine Researchers in the department are involved in the University of Otago Centre for Bioengineering and Nanomedicine which was formed in late 2009. The Centre aims to facilitate the commercial delivery of biomedical and scientific innovations for the benefit of New Zealand and the international community. Research within the Centre at UOC is currently focused on imaging techniques, regenerative medicine and tissue engineering.

Website: www.otago.ac.nz/bioengineering/ouc

Aneurysm repair Research seeks to evaluate the safety and efficacy of new devices and techniques in interventional radiology.

External Grants Awarded 2009-2010

Year PI Project Title Funder $ Approved* Approved

2010 Prof Tim Buckenham Characterisation of atherosclerotic plaques National Heart 134,134 using multispectral CT (MARS) Foundation of NZ

2010 Dr Nigel Anderson MARS – Camera with six Medpix ASICS and New Zealand Lottery 100,000 CdTe hexer detector Grants Board

Postgraduate Students

Total Head Count 2009 2010

PhD - 3

Masters† - - † thesis or dissertation students only

Awards and Scholarships

Year Researcher Award/Scholarship

2010 Dr Mike Hurrell Best 5th Year Consultant Teacher, UOC

2010 Dr Anthony Butler Travel Award, Ministry of Research Science & Technology

80 RESEARCH REPORT 2009/2010 DEPARTMENT OF SURGERY

Head of Department: Professor Frank Frizelle. Email: [email protected]

Major research interests in the Department of Surgery include emergency medicine; ophthalmology; otolaryngology; general, oral and maxillofacial, paediatric, vascular, endovascular and transplant surgery; and urology. Another focus is in the Developmental Genetics Research Group, working in collaboration with Paediatrics.

Website: www.otago.ac.nz/christchurch/departments/surgery/index.html

Major Areas of Research Strength UOC

Helicobacter pylori A range of projects relating to Helicobacter infection in humans are being carried out by the Helicobacter Research Group. Current research centres on the gastric pathogen, Helicobacter pylori and the role that small outer membrane vesicles shed from the bacterial surface play in the development of Helicobacter pylori-associated disease, including gastric cancer. Investigations into the use of common foods to ameliorate Helicobacter pylori-associated gastric inflammation are ongoing. The link between the presence of Helicobacter pylori and inflammatory bowel disease, a precursor for colon cancer is also being studied. Investigations of Mycobacterium avium subsp. paratuberculosis in the aetiology and pathogenesis of Crohn’s disease are also underway.

External Grants > $10,000 Awarded 2009-2010

Year PI Project Title Funder $ Approved* Approved

2010 Dr Jacqui Keenan Camplylobacter: another piece in the Crohn’s New Zealand Lottery 31,207 disease puzzle? Grants Board

2009 Prof Gary Hooper Trans Tasman upper limb fellowship Synthes NZ Ltd 30,000

2009 Dr Jacqui Keenan Adding a 3rd dimension to models for Robert McClelland Trust 17,452 colorectal and pancreatic cancer

* GST exclusive

Postgraduate Students

Total Head Count 2009 2010

PhD 2 2

Masters† 2 3

† thesis or dissertation students only

Awards and Scholarships

Year Researcher Award/Scholarship

2010 Dr Geoffrey Rodgers FRST New Zealand Science and Technology Postdoctoral Fellowship

Division of HEALTH SCIENCES 81 CENTRE FOR POSTGRADUATE NURSING STUDIES

Director of Centre: Dr Lisa Whitehead. Email: [email protected]

The Centre for Postgraduate Nursing Studies is actively involved in research around advancing nursing practice and improving health outcomes for patients nationally and internationally. While there is a nursing emphasis in much of the Centre’s research, studies may not be exclusively focused on nursing.

Website: www.otago.ac.nz/christchurch/departments/nursing/index.html

UOC Major Areas of Research Strength

Management of long-term conditions The focus of this research theme is the development of evidence-based healthcare to minimise the impact of chronic health needs on people’s lives. Research explores symptom experience, risk assessment, preventative care and symptom control issues, with particular emphasis on the enhancement of patient self-management strategies. This programme aims to develop and evaluate care strategies for chronically ill people, such as patient/ client empowerment, treatment adherence, quality of life enhancement, and factors influencing the effectiveness of nursing models of service delivery. The study of chronic health needs encompasses a broad spectrum of disease and age groups to include children, families and older people.

Service delivery and health Research centres around the comparative safety, effectiveness, cost-effectiveness and acceptability of methods of providing health and social care intended to improve outcomes or experience for patients or clients. This group seeks to inform and evaluate the impact of health policy through empirical research and the synthesis of research evidence. Researchers assess innovative approaches to learning and education both to support practitioners and to develop practice in health and social care.

External Grants Awarded 2009-2010

Year PI Project Title Funder $ Approved* Approved

2009 Dr Lisa Whitehead Rhetoric and reality of self-care in New Zealand: Tertiary Education 108,000 patient, professional and policy perspectives Commission STAR programme

2009 Dr Lisa Whitehead Reducing the burden of familial Tertiary Education 97,500 hypercholesterolemia: A mixed method Commission STAR approach programme

2009 Dr Lisa Whitehead Improving diabetes self-management: A Tertiary Education 80,489 randomised controlled trial Commission STAR programme

2009 Dr Lauretta Muir Reducing the burden of familial National Heart 14,070 hypercholesterolemia: Developing a New Foundation of NZ Zealand model of care

* GST exclusive

Postgraduate Students

Total Head Count 2009 2010

PhD 7 10

Masters† 24 30 † thesis or dissertation students only

82 RESEARCH REPORT 2009/2010 Awards and Scholarships

Year Researcher Award/Scholarship

2010 Dr Patricia Maybee Outstanding Research Abstract Award, American Academy of Nurse Practitioners

2010 Dr Mary Jo Gagan Outstanding Research Abstract Award, American Academy of Nurse Practitioners

2009 Virginia Jones STAR PhD Scholarship, TEC

2009 Mandie Wilkinson STAR PhD scholarship, TEC UOC

Division of HEALTH SCIENCES 83 UNIVERSITY OF OTAGO, WELLINGTON

DEPARTMENT OF MEDICINE

Head of Department: Associate Professor Stewart Mann. Email: [email protected]

The Department of Medicine is active in many areas of medical research including disease mechanisms, new treatments and clinical trials of treatments. The Department includes three major research groups which are reflected in the major areas of research strength detailed below. Other academic staff in the department also participate in research appropriate to their subspecialty individually or in collaboration with other departments or outside bodies. UOW Website: www.uow.otago.ac.nz/academic/Med/index.html

Major Areas of Research Strength

Rehabilitation Research into the process and outcomes of rehabilitation is conducted at the Rehabilitation, Teaching and Research Unit (RTRU). Research is aimed at improving the quality of life of people with disabilities in New Zealand. Specific interests include continence, chronic pain, lower back pain, multiple sclerosis, rheumatic disorders, schizophrenia, stroke, spinal cord injury and Parkinson’s Disease.

Website: www.uow.otago.ac.nz/academic/Med/Rehab/index.html

Asthma The Wellington Asthma Research Group’s (WARG’s) research programme covers clinical, biomedical and public health aspects of asthma research, including studies to understand the causes of asthma, the factors that determine severity, and the development of strategies for prevention and improved management. In recent times, a key study by the Group has shown that use of a probiotic supplement significantly reduces the rate of childhood eczema in infants under two. Another study revealed that synthetic bedding contains higher levels of fungal cell products than feather bedding, providing a possible explanation for the higher rates of asthma symptoms associated with use of feather bedding in New Zealand homes. The group collaborates locally with the Housing and Health research programme in the Department of Public Health and internationally with UCLA Berkeley on studies of hydrogen sulphide exposure and health.

Website: www.uow.otago.ac.nz/academic/Med/warg/index.html

Sleep disorders Sleep research is the focus of WellSleep, a sleep investigation centre which provides diagnostic and treatment for a variety of different sleep disorders including sleep apnoea, nocturnal hypoventilation, periodic limb movements during sleep, narcolepsy, and parasomnias. The centre also conducts research into a variety of sleep disorders. Recent research topics include: the effects of warm air humidification on nasal CPAP compliance in obstructive sleep apnoea; a pilot study of the impact of sleep disorders in road traffic accidents; the effectiveness of a mandibular advancement splint in treating mild obstructive sleep apnoea and snoring; polysomnographic studies of sleep and respiration effects of position in pre-term infants.

Website: www.uow.otago.ac.nz/academic/Med/Wellsleep/index.html

84 RESEARCH REPORT 2009/2010 External Grants > $30,000 Awarded 2009-2010

Year PI Project Title Funder $ Approved* Approved

2010 Dr Tristam Ingham Whiti te Ra: Bronchiolitis disparities among Health Research 1,146,720 Mäori and Pacific children Council of NZ

2010 Dr Jeremy Krebs Integrated secondary specialist service in Health Research 191,555 primary care team diabetes management Council of NZ

UOW 2010 Prof Julian Crane RCT of regular paracetamol in mild to Health Research 65,336 moderate asthma Council of NZ (subcontract)

2009 Prof Julian Crane H2S Absorption in Rotorua – Extension National Institutes of 176,533 Health (subcontract)

2009 Prof Julian Crane Nicotine inhaler plus patch in smoking cessation Health Research 1,353,244 Council of NZ

2009 Prof Julian Crane Zonnic (oral nicotine) and nicotine patch in Health Research 1,116,305 smoking cessation Council of NZ

2009 Dr Kristin Wickens 6 year follow-up of the effects of probiotics on Health Research 986,764 development of allergic disease Council of NZ

2009 Prof Julian Crane H2S Absorption in Rotorua National Institutes of 434,385 Health (subcontract)

2009 Prof Julian Crane RCT of regular Paracetamol in mild to Medical Research 65,336 moderate asthma Institute of New Zealand

2009 Dr Angela Campbell The effects of ethnicity on compliance to New Zealand Lottery 46,826 CPAP treatment Grants Board

2009 Dr Bernadette Jones He Kura Aro Huango: How are primary schools Asthma and Respiratory 35,974 responding to the needs of Mäori children Foundation of with asthma? New Zealand 35,974

* GST exclusive

Commercial Contracts

Year Approved Organisation

2009-10 ACC Auckland Uniservices Dynamic Controls Hutt Valley District Health Board New Zealand Honey Specialties Ltd P3 Research Pharmacy Guild of New Zealand Rex Medical Ltd Synlait Milk Ltd Waikato District Health Board

Total 964,832

Division of HEALTH SCIENCES 85 Postgraduate Students

Total Head Count 2009 2010

PhD 17 16

Masters† 16 13 † thesis or dissertation students only

Awards and Scholarships UOW

Year Researcher Award/Scholarship

2010 Professor Richard Beasley Deputy Chair, Health Research Council of NZ

2010 Professor Richard Beasley Asian Pacific Society of Respirology Woolcock Research Medal

DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY

Head of Department: Professor Kevin Pringle. Email: [email protected]

Research interests in the Department of Obstetrics and Gynaecology are varied and include renal dysphagia, hydronephrosis, prenatal diagnosis and therapy, endometriosis, incontinence following delivery, perinatal outcomes following caesarean section, fertility, assisted reproductive techniques, perinatal pathology, and sudden infant death syndrome.

Website: www.uow.otago.ac.nz/academic/OandG/index.html

DEPARTMENT OF PAEDIATRICS AND CHILD HEALTH

Head of Department: Dr Thorsten Stanley Email: [email protected]

The members of the Department of Paediatrics and Child Health are committed to conducting high quality research into common and important childhood diseases and to ensure the knowledge gained is translated into improved adolescent and child health outcomes. Current research focuses on paediatric infectious disease, cystic fibrosis, bronchiectasis, vascular complications of diabetes, hypoglycaemia, childhood epilepsy, respiratory control in newborn babies and preterm infants, sexual assault, childhood asthma, eczema and allergy, and the effect of pre- and probiotics on the development of these disorders.

Website: www.wnmeds.ac.nz/academic/paediatrics/index.html

Major Areas of Research Strength

Epilepsy The epilepsies are a common group of disorders. A significant proportion of them are inherited and due to genetic factors. The Wellington Epilepsy Research Group is undertaking research aimed at further delineation of the clinical features and genetics of epilepsies found in families, and identifying genes for these epilepsies. Finding new epilepsy syndromes and the genes responsible for these will allow more accurate diagnosis and prognosis, and lead to novel improved therapies.

Sleep and breathing The department is collaborating with colleagues in the Department of Surgery and Anaesthesia on research into measures of respiratory variability and cardiorespiratory interactions in infants and children. There are also collaborations with Massey University on research into actigraphy measures of sleep in children at various ages.

Diabetes Research in this area examines the origins of vascular disease in children with diabetes, with the aim of developing new strategies to prevent development or progression of vascular complications of diabetes from an early stage. It also involves risk factors and treatment of hypoglycaemia in diabetes.

86 RESEARCH REPORT 2009/2010 Allergy and Asthma Studies recently completed or ongoing include the long term benefits of perinatal and early childhood supplementation with probiotics on the subsequent development of eczema, asthma rhinitis and atopy; the role of indoor mould cold and damp in asthma; the value of exhaled nitric oxide in the management of asthma and desensitisation; the importance of endotoxin on atopic sensitisation; gut permeability in early childhood eczema; the mechanisms by which probiotics and prebiotics alter atopic sensitisation; the benefits of different materials on infantile eczema; the role of housing conditions and vitamin D status on the development of bronchiolitis. There are strong research links with the Wellington Asthma Research Group and the Housing and Health Research Programme.

External Grants Awarded 2009-2010 UOW Year PI Project Title Funder $ Approved* Approved

2010 Dr Lynette Sadleir Defining the genetic determinants for epilepsy Health Research 1,158,831 Council of NZ

2009 Dr Lynette Sadleir Epilepsy genetics Child Health Research 99,871 Foundation

* GST exclusive

Postgraduate Students

Total Head Count 2009 2010

PhD - 1

Masters† - - † thesis or dissertation students only

DEPARTMENT OF PATHOLOGY AND MOLECULAR MEDICINE

Acting Head of Department: Dr Michael Humble. Email: [email protected]

The Department of Pathology and Molecular Medicine is a multidisciplinary unit in which the subdisciplines of haematology, microbiology, chemical pathology, anatomical pathology and molecular pathology are represented. Current research activities within the Department focus on the causes and behaviour of various cancers with a specific emphasis on breast, cervix, kidney, prostrate and bladder malignancy. Dental research and urogenital pathology are also areas of research interest.

Website: http://www.wnmeds.ac.nz/academic/pathology/index.html

Major Areas of Research Strength

Dental research The Dental Research Unit has an extensive research programme investigating dental mineralisation, causes of tooth decay and oral microbiology. Studies to date include plaque growth and development, regulation of plaque pH, urea metabolism, plaque mineralisation by calcium phosphates, enamel demineralisation and fluoride effects, antiplaque agents, and the biodiversity and ecology of dental plaque bacterial communities. The Unit houses a novel computer-controlled ‘multiplaque artificial mouth’. This allows the development of realistic plaque microcosm biofilm model systems.

Urogenital pathology Research activities are focussed on the classification, diagnosis, molecular biology, growth kinetics and outcome prediction for adult and childhood renal tumours. Other areas of research are: the pathogenesis and spread of bladder cancer; the pathenogenesis, diagnosis and behaviour of testicular tumours and prostate cancer; and progeria kidney.

Molecular pathology The Wakefield Biomedical Research Unit moved to the department from Wakefield Hospital in 2009. It has a strong research focus on the molecular basis of the spread of colorectal cancer and the fundamental cause of insulin resistance, type 2 diabetes and obesity.

Division of HEALTH SCIENCES 87 Prostate cancer research The Prostate Cancer Trials Unit is a research unit within the department participating in international and local clinical trials to treat prostate cancer. Research activities are focussed on the classification, in particular the Gleason categories, diagnosis and effective treatment of prostate cancer.

External Grants > 10,000 Awarded 2009-2010

Year PI Project Title Funder $ Approved* Approved

UOW 2010 Prof David Lamb RADAR Prostate Cancer Trial Cancer Society of 455,120 New Zealand

2010 Dr Richard Stubbs Pilot study of gastric bypass to resolve Lottery Health 97,500 type 2 diabetes

2010 Dr Richard Stubbs Epigenetics and Obesity ESR, Porirua 30,000

2010 Dr Mark Hayes Isolation and identification of gut derived proteins Wellington Medical 29,940 and peptides post gastric bypass surgery Research Foundation

2009 Dr Jonathan Foo Clinical Training Research Fellowship Health Research Council 255,930 New Zealand

2009 Dr Richard Stubbs Contribution to colorectal cancer programme Wakefield Health Ltd 200,000

2009 Dr Chandra Kirana Protein biomarkers for predicting colorectal Lottery Grant Board, 116,000 cancer spread Postdoctoral Award

2009 Dr Richard Stubbs Role of p53’s transactivation domain in tumour Genesis Oncology Trust 57,270 suppression – a proteomic study

2009 Dr Mark Hayes Decodon Delta 2D gel analysis software. Lottery Health Research 25,078 Equipment grant

2009 Dr Chandra Kirana Protein biomarkers for predicting colorectal Wellington Medical 18,899 cancer spread Research Foundation

2009 A/P Chris Sissons Microbial analysis of dental plaque samples in Otago Medical Research 15,185 the Dunedin Multidisciplinary Health and Foundation Developmental Study

2009 Hongjun Shi Measurement and evaluation of six potential Cancer Society of 15,000 novel serum biomarkers for colorectal cancer New Zealand, Wellington Division

2009 Dr Chandra Kirana Protein biomarkers for predicting colorectal Cancer Society of 11,941 cancer spread New Zealand, Wellington Division

* GST exclusive

Commercial Contracts

Year Approved Organisation

2009-10 National University of Singapore

Total 63,722

88 RESEARCH REPORT 2009/2010 Postgraduate Students

Total Head Count 2009 2010

PhD 5 5

Masters† 1 1 † thesis or dissertation students only

Awards and Scholarships UOW

Year Researcher Award/Scholarship

2010 A/P John Carter Member of the New Zealand Order of Merit (MNZM) for services to medicine

2010 Prof Brett Delahunt Wellington Medical Research Foundation’s 50th Jubilee Medal

2010 Prof Brett Delahunt Fellow of the Faculty of Science of the Royal College of Pathologists of Australasia

2010 Prof Brett Delahunt Appointed Medical Board Professor, Royal Prince Alfred Hospital, Sydney

2010 Dr St John Wakefield Fellow of the Faculty of Science of the Royal College of Pathologists of Australasia

2010 Dr Jonathan Foo Richard Stewart Fellowship

2009 Prof Brett Delahunt Gold Medal as Distinguished Fellow of the Royal College of Pathologists of Australasia in recognition of lifetime achievement in pathology research

2009 Prof Brett Delahunt Distinguished Service Medal of the New Zealand Society of Pathologists for an outstanding contribution to the advancement of Pathology both nationally and internationally

2009 Dr Erin Mahoney, Best Paper in the New Zealand Dental Journal David Morrison

DEPARTMENT OF PRIMARY HEALTH CARE AND GENERAL PRACTICE

Head of Department: Dr Sue Pullon. Email: [email protected]

The interdisciplinary research undertaken within the Department informs practitioners and consumers, patients and policy makers about many aspects of health and health care.

Website: www.wnmeds.ac.nz/academic/gp/index.html

Major Areas of Research Strength

Women’s health Many diseases including osteoporosis, depression, breast cancer, menopause and Alzheimer’s disease differentially affect women. The Women’s Health Research Centre (WHRC) works collaboratively, both internationally and locally, to explore important health challenges for New Zealand women. Key areas of research focus include: mid-life health, diabetes and heart disease, health and well being for young pregnant women, and sexual reproductive health. Research is conducted within a kura kaupapa framework. Other areas of interest include: osteoporosis, contraception, fertility, unplanned pregnancy, maternity and health of the newborn.

Website: www.wnmeds.ac.nz/academic/gp/whrc/index.html

Division of HEALTH SCIENCES 89 Communication in health care Communication in health care research is the domain of the Applied Research on Communication on Health (ARCH) Group, with a particular focus on effective health professional to patient communication. Major studies to date include the Interaction Study: Exploring Clinical Decision-Making when Rationing is Explicit (2003- 2005); Tracking Health Care Interactions: Patient- Professional Communication; and Understanding Diabetes Management- Tracking Communication in Primary Care (2008-2010). Members of the ARCH core group have been collecting and analysing video recordings of naturally occurring interactions between health practitioners and patients since 2003. These have now been permanently archived along with various related data in the ARCH Corpus, a searchable digitised collection of health care interactions and related data for use in interaction analysis, the first data set of its kind in New Zealand.

UOW Website: www.wnmeds.ac.nz/academic/gp/research/index.html

Mental health The Department has a longstanding involvement in mental health care research. Academics from the Department in collaboration with the Department of Psychological Medicine were responsible for producing the landmark Mental Health in General Practice (MaGPie) study which described the prevalence, form, course and outcome of common mental disorders in New Zealand general practices. The Department has also been responsible, together with colleagues from Psychological Medicine, for the evaluation of the Ministry of Health funded programme of Primary Mental Health Initiatives, the development of toolkits for primary mental health care and the production of an ultra-brief psychological intervention for consultation use. The Department is currently involved in two randomised controlled trials in mental health care, the first of light and exercise therapy in dementia and the second of anti-depressant cessation in general practice. A member of the Department is also working with a WHO panel involved in the mental health component of the revised international classification of disease ( ICD-11).

Health services research A variety of projects and studies in health services research have been completed and include: the evaluation of Mid Central District Health Board mobile nursing service; Pathways Study; Primary Health Care Nurse Education Nelson Bays Primary Health Care Report; utilisation of primary health care: analysis of routinely collected data (HURA); performance indicators in primary care, and the capacity of routine primary care to manage pandemic influenza.

Addictive and lifestyle research The Taboo (Tackling Obesity) study builds on earlier work undertaken by the ARCH group (above). A study on families living with addiction has just been completed, and an investigation into addictive behaviour education for medical students is in progress.

External Grants > $30,000 Awarded 2009-2010

Year PI Project Title Funder $ Approved* Approved

2010 Dr Beverley Lawton Addressing barriers to care for young pregnant Health Research 1,199,936 Mäori women and their infants Council of NZ

2010 Dr Thomas Love Capacity of routine primary care to manage Health Research 249,800 pandemic influenza Council of NZ

2010 Dr Wei Zhang Exploring Access to Breast Cancer Services by New Zealand Lottery 63,000 Chinese Women Grants Board

2009 Dr Beverley Lawton Wahine hauora: Reducing barriers to care for Health Research 1,179,945 pregnant mums and whanau Council of NZ

2009 Dr Sally Rose Towards prevention of rapid repeat abortion New Zealand Lottery 103,690 among at-risk women Grants Board

2009 Dr Wei Zhang Chinese women’s use of and New Zealand Lottery 83,207 attitudes towards contraception Grants Board

2009 Prof Tony Dowell Traumatic brain injury burden in New Zealand: Health Research 60,995 A population-based incidence and outcomes Council of NZ study (subcontract)

* GST exclusive

90 RESEARCH REPORT 2009/2010 Commercial Contracts

Year Approved Organisation

2009-10 Medical Council of New Zealand Wairarapa District Health Board

Total 20,000

Postgraduate Students UOW

Total Head Count 2009 2010

PhD 2 2

Masters† 4 5 † thesis or dissertation students only

DEPARTMENT OF PSYCHOLOGICAL MEDICINE

Head of Department: Professor Pete Ellis. Email: [email protected]

The Department of Psychological Medicine’s research programme is configured around several themes relevant to mental health practice in the New Zealand setting, including: ~ mental health service delivery and evaluation, including in primary care ~ the interface between psychological and physical health ~ social psychiatry ~ psychiatric epidemiology ~ suicide ~ education in the clinical professions.

Website: www.uow.otago.ac.nz/academic/psych/index.html

Major Areas of Research Strength

Psychiatric disorders These studies include epidemiology, schizophrenia and sleep disorders. This stream includes the epidemiological work of Dr Kate Scott in connection to Te Rau Hinengaro, The New Zealand Mental Health Survey, part of the WHO World Mental Health Surveys studies on schizophrenia and sleep disorders.

Interventional therapies Research activity here ranges from psychopharmacological to cognitive-behavioural therapies and includes work with consumers and government agencies.

External Grants Awarded 2009-2010

Year PI Project Title Funder $ Approved* Approved

2009 Dr Kate Scott Double disability: mental disorders and Health Research 154,575 co-morbid physical conditions Council of New Zealand

2009 Prof Pete Ellis Outcome of suicide prevention in a youth New Zealand Lottery 33,778 welfare population Grants Board

2009 Fiona Mathieson Mäori adaption of a brief intervention for Oakley Mental Health 10,000 common mental health syndromes in Research Foundation primary care

* GST exclusive

Division of HEALTH SCIENCES 91 Postgraduate Students

Total Head Count 2009 2010

PhD 3 1

Masters† - - † thesis or dissertation students only UOW DEPARTMENT OF PUBLIC HEALTH

Head of Department: Professor Richard Edwards. Email: [email protected]

For a number of years the main focus of the Department’s research work has been monitoring, understanding and mitigating inequalities in health. The Department also has research strengths in the areas of housing and health, sustainable cities, health promotion and policy in relation to tobacco, nutrition and obesity, health services research, Māori health, cancer control and screening, infectious diseases and health impact assessment.

Website: www.wnmeds.ac.nz/academic/dph/index.html

Major Areas of Research Strength

Housing and health He Kainga Oranga, the Housing and Health Research Programme, seeks to examine and elucidate the links between housing and health. The aim is to identify and then evaluate housing-related interventions to improve individual, family and community health. Examples of current studies include Warm Homes for Elder New Zealanders; Measuring Homelessness; the Tokelau Extended Family Housing Study; Healthy Housing Index; Latent Tuberculosis Infection; and the Health of Occupants of Mouldy Environments.

Website: www.healthyhousing.org.nz/

Sustainable cities In 2008, the New Zealand Centre for Sustainable Cities was established by members of the He Kainga Oranga programme. The Centre is dedicated to providing the research base for innovative solutions to the economic, social, environmental and cultural development of New Professor Tony Blakely (Left) and Dr Kristie Carter are investigating Zealand’s urban centres. ethnic and socio-economic disparities and trends in mortality and health in New Zealand. Website: http://sustainablecities.org.nz/

Health inequalities research The Health Inequalities Research Programme (HIRP) is an HRC funded programme established in July 2005 to explore, explain and provide solutions for systematic health inequalities in New Zealand. There are eight projects within the HIRP programme: CancerTrends; Differential Colon Cancer Survival by Ethnicity in New Zealand; Neighbourhoods and Health; the New Zealand Census-Mortality Study; Social Indicators (NZDep, NZiDep); SoFIE-Health; SoFIE-Primary Care; and Unequal Treatment – the Role of Health Services.

Website: www.wnmeds.ac.nz/academic/dph/research/HIRP/index.html

Health services research and prioritisation Health services research covers the spectrum from prevention to palliation. A major study is the HRC funded Burden of Disease Epidemiology, Equity and Cost-Effectiveness (BODE3) study. The aim of this study is to build capacity and academic rigour in New Zealand in the estimation of disease burden, cost-effectiveness and equity impacts of proposed interventions, and undertake a range of such assessments. The projects within BODE3 are: ~ the Aotearoa Burden of Cancer and Comparative Benefit Assessment study (ABC-CBA) ~ the NZ-Assessing Cost-effectiveness – Prevention (NZ-ACE) study

Website: www.wnmeds.ac.nz/academic/dph/research/bode/bode_index.html

92 RESEARCH REPORT 2009/2010 Mäori health The focal point for Mäori health research in the department is Te Röpü Rangahau Hauora a Eru Pömare. The goals of the Centre are to promote and foster health research by, and for, Mäori and to provide an environment in which Mäori can be trained in a variety of research techniques. Health disparities and unequal treatment between Mäori and non-Mäori are the foundation of the Centre’s research. Current research themes include breast cancer screening, cancer incidence and statistics, ethnicity, health effects of involuntary job loss, oral health, and access to health services.

Website: www.wnmeds.ac.nz/academic/dph/research/Mäori/index.html

Health promotion and policy research

The Health Promotion and Policy Research Unit (HePPRU) is the hub for policy-oriented research into tobacco, food and UOW obesity within the department. Current major research themes include: the development, implementation and evaluation of policy interventions for tobacco control in order to achieve a tobacco free NZ (Tupeka Kore Aotearoa); and investigations into policy-relevant issues in nutrition and food policy such as food marketing in sport settings and Pacific perspectives on promoting children’s healthy eating.

Website: www.wnmeds.ac.nz/academic/dph/research/heppru/index.html

Cancer control and screening This is a growing area of research interest within the department. Examples of current projects include investigations into: the role of comorbidity and unequal treatment among Mäori with cancer (C3 project); colon cancer screening feasibility in New Zealand; cancer outcomes among mental health service users, and modelling of future services and costs for screening, treatment and follow-up for people with colon cancer in New Zealand. There is also collaborative work underway on cervical cancer, and Vitamin D and cancer.

Website: www.wnmeds.ac.nz/academic/dph/research/CCSRG/CCSRG_index.html

Social psychiatry and mental health The purpose of the Social Psychiatry and Mental Health (SoPop) Group is to contribute to knowledge, policy, and services by conducting research and teaching in the areas of mental health, mental illness, and suicide prevention. The group takes the perspective that understanding mental health and mental illness cannot be achieved without acknowledging the social context. In 2009, over $5 million in funding was received from the Ministry of Health for a Multilevel Intervention Suicide Prevention trial (MISP).

Website: www.wnmeds.ac.nz/academic/dph/research/socialpsychiatry/index.html

External Grants > $50,000 Awarded 2009-2010

Year PI Project Title Funder $ Approved* Approved

2010 Prof Tony Blakely Burden of Disease Epidemiology, Equity and Health Research 4,996,275 Cost-Effectiveness Programme (BODE3) Council of NZ

2010 Dr Diana Sarfati C3 study: Effect of comorbidity on care and Health Research 1,171,238 cancer survival inequalities Council of NZ

2010 Dr Ricci Harris Racism as a health determinant: implications for Health Research 600,032 Mäori health and inequalities Council of NZ

2010 Silke Kuehl The suicide and serious harm risk of “Mixed Health Research 250,000 Presenters” to emergency departments Council of NZ – Clinical Research Training Fellowship

2010 Dr Ruth Cunningham Health outcomes for mental health service Health Research 250,000 users- exploring the case of cancer Council of NZ – Clinical Research Training Fellowship

2010 A/P Michael Baker Ethnic and socioeconomic differences in Health Research 229,323 pandemic influenza infection in New Zealand Council of NZ

Division of HEALTH SCIENCES 93 2010 Dr Louise Signal SPEND trial: Strategic pricing – effects on Health Research 140,259 nutrition and disease Council of NZ (subcontract)

2010 Dr Janet McDonald The process and experience of family carers Health Research 113,450 managing nursing procedures at home Council of NZ

2010 Dr Melissa McLeod Towards understanding seclusion and restraint Te Pou 99,177 of Mäori

UOW 2009 Prof Sunny Collings MISP – Multilevel intervention Suicide Ministry of Health 5,013,815 prevention trial

2009 Prof Philippa He Kainga Organga / Community Healthy Health Research 2,966,584 Howden-Chapman Housing Intervention Research Programme Council of NZ

2009 Prof Sunny Collings The Nature and extent of informal coercion in Health Research 1,884,065 community mental health in New Zealand Council of NZ

2009 Dr Louise Signal Is junk food promoted through sport? Health Research 501,490 Council of NZ

2009 Dr Karlo Mila-Schaaf Developing a Pacific mental health intervention: Health Research 362,310 What is therapeutic? Council of NZ

2009 Moira Smith Attitudes of children and adults to the food Health Research 227,425 environment in organised sport Council of NZ – Clinical Research Training Fellowship

2009 Caroline Shaw Quantifying the health effects of climate change Health Research 227,227 mitigation policies in NZ Council of NZ – Clinical Research Training Fellowship

* GST exclusive

Commercial Contracts

Year Approved Organisation

2009-10 Capital and Coast District Health Board Katoa Ltd Ministry of Health Ministry of Social Development Ministry of Transport MOTU Economic and Public Policy Research Trust Quigley and Watts Ltd Te Atawhai o Te Ao Terralink

Total 1,038,124

Postgraduate Students

Total Head Count 2009 2010

PhD 22 28

Masters† 11 6 † thesis or dissertation students only

94 RESEARCH REPORT 2009/2010 Awards and Scholarships

Year Researcher Award/Scholarship

2010 Dr Ruth Cunningham HRC Clinical Research Training Fellowship (PhD student)

2010 Dr Silke Kuehl HRC Clinical Research Training Fellowship (PhD student)

2009 Prof Philippa Companion of the Queen’s Service Order for services to public health UOW Howden-Chapman

2009 Prof Philippa Public Interest Award, New Zealand Psychological Society Howden-Chapman

2009 Caroline Shaw HRC Clinical Research Training Fellowship (PhD student)

2009 Moira Smith HRC Clinical Research Training Fellowship (PhD student)

2009 Kate Amore TEC Bright Future Top Achiever Doctoral Scholarship (PhD student)

DEPARTMENT OF RADIATION THERAPY

Head of Department: Ms Karen Coleman. Email: [email protected]

Website: www.uow.otago.ac.nz/academic/radiationtherapy/index.html

Major Areas of Research Strength

Cancer biology Cancer research is being undertaken in conjunction with the Malaghan Institute of Medical Research and the Peter MacCallum Cancer Institute in Melbourne, Australia. The focus is on highly glycolytic cancers that are very aggressive and resistant to radiation and chemotherapies. Research currently focuses on understanding the mechanism of action of radiation resistance and on exploring ways of overcoming resistance.

Clinical trials A number of clinical trials for treatment of side effects of radiation treatment are ongoing and include: use of Mepilex dressings for radiation-induced skin reactions in women treated for breast cancer; manuka honey for radiation-induced oral mucositis in patients treated for head and neck cancer. Possible future trials include cranberries for radiation induced cystitis, and probiotics for radiation-induced diarrhoea.

Psycho-oncology Psycho-oncology is the investigation into the psychosocial impact of cancer and its treatments, and is undertaken in areas with particular relevance to the radiation therapy profession. One study has investigated the effect that treating cancer patients has on radiation therapy students.

Cancer Support Services The benefit of support and education services to cancer patients and their supporters has been clearly demonstrated in other countries. In New Zealand these services are being provided by the Cancer Society but they do not always enjoy the support of health professionals resulting in poor referral rates. A series of formal evaluations of one support and education programme run by the Cancer Society of New Zealand aim to ascertain whether this programme meets the needs of cancer patients and their support people and determine whether health providers can be confident in referring patients to this programme.

Division of HEALTH SCIENCES 95 External Grants > $5,000 Awarded 2009-2010

Year PI Project Title Funder $ Approved* Approved

2010 Mr Paul Kane Cancer Society facilitators – Are we Cancer Society of 5,000 facilitating them? New Zealand

2009 Dr Patries Herst The effect of Mepilex Lite dressings on the Healthcare Otago 20,320 management on radiation induced skin reactions Charitable Trust

UOW 2009 Dr Patries Herst The effect of Mepilex Lite dressings on the Cancer Society of 12,250 management on radiation induced skin reactions New Zealand

* GST exclusive

Commercial Contracts

Year Approved Organisation

2009-10 Ministry of Science and Innovation

Total 26,000

DEPARTMENT OF SURGERY AND ANAESTHESIA

Head of Department: Associate Professor Duncan Galletly. Email: [email protected]

The Department of Surgery and Anaesthesia is involved in a range of research fields including surgery, anaesthesia, resuscitation, emergency medicine and cardio-respiratory physiology.

Website: www.wnmeds.ac.nz/academic/dos/index.html

Major Areas of Research Strength

Circulation control (PI S. Tzeng) ~ Baroreflex regulation of blood pressure ~ Cerebral blood flow regulation ~ Sympathetic neurovascular control of vasomotor function

Ventricular rhythm disturbances (PI P. Larsen) ~ ECG based risk stratification for ventricular tachyarrhythmias ~ Characteristics of ventricular fibrillation ~ Utilisation of implantable cardioverter defibrillators

Prehospital emergency care (PI A. Swain) ~ Does a dual fire service and paramedic response improve survival from community cardiac arrest ~ Is survival from community cardiac arrest linked to socioeconomic status or location in the Wellington area ~ Extended care paramedics – do they reduce hospital emergency attendances ~ Extended care paramedics – a randomised controlled trial of ECP care versus standard paramedic care ~ Extended care paramedics – what do the patients think and what is the clinical outcome of ECP care

96 RESEARCH REPORT 2009/2010 External Grants > $5,000 Awarded 2009-2010

Year PI Project Title Funder $ Approved* Approved

2010 Dr Shieak Tzeng Influence of tobacco smoking on dynamic Health Research 500,000 cerebral autoregulation Council of NZ – Charles Hercus Research Fellowship

2009 Dr Shieak Tzeng Autonomic modulation of pulmonary gas Health Research 145,854 UOW exchange efficiency Council of NZ

2009 Grant Cave Investigation of lipid emulsions in toxicology New Zealand Lottery 38,595 and neonatal jaundice Grants Board

2009 Dr Andrew Swain Do emergency care paramedics reduce Wellington Medical 13,000 hospital emergency attendances? Research Foundation

* GST exclusive

Postgraduate Students

Total Head Count 2009 2010

PhD 5 6

Masters† 1 2 † thesis or dissertation students only

Awards and Scholarships

Year Researcher Award/Scholarship

2010 Dr Shieak Tzeng Sir Charles Hercus Research Fellowship, Health Research Council of New Zealand

2009 Dr Shieak Tzeng AMP Scholarship

Division of HEALTH SCIENCES 97 SCHOOL OF PHARMACY

Dean: Professor Stephen Duffull. Email: [email protected]

The School of Pharmacy has a very active research programme, the aim of which is ‘optimisation of drug therapy’.

Website: http://pharmacy.otago.ac.nz/index.html

Major Areas of Research Strength

PHARMACY Fundamental drug research Research in this area includes drug discovery, drug metabolism and drug action to extend the range of drugs available and to provide a scientific basis for the quality use of medicines and bioactive substances. Specific areas of research include: computational methods encompassing rational, structure and analogue based drug design techniques, QSAR, drug target identification and lead optimisation; preclinical assessment of new chemical entities including small molecular weight and polypeptide bioactives; development of analytical methods for drugs in formulations and body fluids; studies on drugs of abuse aimed at harm minimisation and for application in forensic toxicology; and pharmacokinetic and toxicity studies on synthetic bioactives and those extracted from natural sources.

Drug formulation and delivery Bioactive materials such as drugs, vaccine antigens, pesticides and nutrients cannot be administered in their pure form, but must be incorporated into biocompatible formulations which maintain their stability and deliver them in a way that achieves optimal beneficial effects while minimising unwanted side effects. This field has important human, veterinary and agricultural applications. Research in Formulation and Delivery of Bioactives has been designated a Research Theme by the University of Otago.

Clinical pharmacy Clinical pharmacy is the area of pharmacy concerned with patient care and the optimisation of medicine use in order to promote health and wellness, and prevent disease. Research in this area includes biopharmaceutical, pharmacokinetic and pharmacodynamic strategies to optimise drug therapy in patients; consideration of adverse or toxic events to minimise harm; the study of special populations; and optimal use of medicines.

Social Pharmacy The underlying theme of this research is to improve access to, and the use of, medicines. Several projects explore medicines use in the community, a number of which involve using large datasets to examine medicines use by gender, age, ethnicity and socio-economic status. Other projects look at the extent of medicines wastage in the community and lay people’s understanding and use of medicines. Staff members have an interest in pharmacy practice in developing countries. Recent projects investigate the quality of medicines in South Africa, and other staff members have carried out research in the South Pacific. The evaluation of pharmaceutical policy is also an important theme in the group’s work.

External Grants > $10,000 Awarded 2009-2010

Year PI Project Title Funder $ Approved* Approved

2010 Prof Pauline Norris Access to pharmacy services: investigating New Zealand 11,105 changes over time in the number and location Pharmacy Education of pharmacies and Research Foundation

2010 Prof Steve Duffull A comparison of two dose individualisation New Zealand 10,926 methods for warfarin therapy Pharmacy Education and Research Foundation

2010 Dr Joel Tyndall New azoles for emerging fungal pathogens Otago Medical 10,600 Research Foundation

2010 Prof Stephen Duffull The impact of renal tubular function on drug Laurenson Award 31,908 handling in the elderly

2009 Prof Thomas Rades Effects of the fatty acid, lauric acid, on energy National Health and 260,000 intake and gut motor and hormonal function in Medical Research health and obesity Council (Australia)

98 RESEARCH REPORT 2009/2010 2009 Prof Ian Tucker Investigations into the transport and metabolism New Zealand Lottery 78,839 of drugs Grants Board

2009 Dr June Tordoff Community pharmacy services to older people Pharmacy Guild of 29,450 in the community New Zealand

2009 Dr Anja Graf Investigation of colloidal formulations as sustained Otago Medical 15,692 release vaccines Research Foundation

2009 Dr Natalie Medlicott Neonatal infusions – what’s the dose? New Zealand 12,078

Pharmacy Education PHARMACY and Research Foundation

2009 Dr Joel Tyndall Validating essential enzymes as targets for new Maurice and Phyllis 12,000 broad spectrum antifungal compounds Paykel Trust

2009 Dr Arlene McDowell Preformulation of Puha for an antioxidant Laurenson Award 11,990 nutritional supplement

2009 A/P Paul Fawcett Stereoselectivity of transporters of ketotifen New Zealand 10,828 and norketotifen at the blood brain barrier Pharmacy Education and Research Foundation

* GST exclusive

Commercial Contracts

Year Approved Organisation

2009-10 Boehringer-Ingelheim Pty Ltd Germany Bioneer A/S Denmark Douglas Pharmaceuticals Glenmark Pharmaceuticals SA Switzerland Innate Therapeutics Ltd Intervet Shering Plough Animal Health Mastitis Research Centre Ltd Ministry of Science and Innovation Pepsico Inc Roche Switzerland Taranaki District Health Board TB Alliance Zenith Technology Corp Ltd

Total 1,378,491

Postgraduate Students

Total Head Count 2009 2010

PhD 42 46

Masters† - 1 † thesis or dissertation students only

Division of HEALTH SCIENCES 99 SCHOOL OF PHYSIOTHERAPY

Dean: Professor David Baxter. Email: [email protected]

Research and knowledge transfer are integral parts of the School’s activities, and these areas continue to develop rapidly. The School has active research programmes in a variety of rehabilitation related areas, which are managed through the New Zealand Centre for Physiotherapy Research. Current research interests are varied and include lower back pain, neurorehabilitation, rehabilitation in multiple sclerosis, physiological and clinical effects of electrophysical agents.

Website: http://physio.otago.ac.nz PHYSIOTHERAPY Major Areas of Research Strength

REAL (Rehabilitative Exercise and Activity for Life Neurological Research Group) Research focuses on physiotherapy interventions and measurement that enhances participation in daily life for populations with neurological dysfunction and older adults. Current research areas include fall intervention programmes for a number of different cohorts, exercise interventions for those with multiple sclerosis and Parkinson’s disease, and measuring and enhancing physical activity. A current clinical study is investigating the potential of aqua aerobics to improve the risk of falls and physical function in older adults with lower extremity osteoarthritis.

Website: http://physio.otago.ac.nz/res/groups/real.html

AMOCK (Advancement of Musculoskeletal, Occupational Health and Clinical Knowledge Research Group This theme involves a diverse range of research projects in the areas of rural ergonomics, biomechanical studies, activity monitoring, low level laser therapy, thoraco-lumbar postures, osteoarthritis interventions/treatments and more. A major theme is rural ergonomics, an important research area in New Zealand where large numbers of workers are employed in the rural sector. Recently completed projects include a study into spinal injuries in farmers caused by exposure to vibrations from extended use of quad bikes, and a study examining the forces exerted on the spines of shearers including an investigation into the beneficial effects of using back harnesses.

Website: http://physio.otago.ac.nz/res/groups/amock.html

SPEX (Sport and Exercise Research Group) Research focuses on injury mechanisms, injury screening and prevention, and rehabilitation strategies for sport and exercise injuries. An additional area of interest is the use of exercise to promote health and a healthy lifestyle across the entire lifespan. Currently, researchers are developing a pre-hospital sideline assessment tool for use by sports physiotherapists to screen for concussion. Also ongoing is a study into whether musculoskeletal screening can predict injury in elite athletes.

Website: http://physio.otago.ac.nz/res/groups/spex.html

External Grants > $10,000 Awarded 2009-2010

Year PI Project Title Funder $ Approved* Approved

2010 Dr Karen Peebles National Heart Foundation Fellowship National Heart 180,000 Foundation of NZ

2010 Dr Allan Carman RSscan foot pressure measurement for balance New Zealand Lottery 30,631 and neurological research Grants Board

2010 Dr Hilda Mulligan Access to recreation to enable a physically active Burwood Academy 25,000 lifestyle for individuals with physical disability of Independent Living

2010 Dr Leigh Hale Body composition, balance, strength and falls Physiotherapy 16,000 in older adults with Parkinson’s disease New Zealand

2009 Dr Gill Johnson Spinal posture, mobility and low back pain Sport and Recreation 23,607 incidence in female junior rowers New Zealand (SPARC)

* GST exclusive

100 RESEARCH REPORT 2009/2010 Commercial Contracts

Year Approved Organisation

2009-10 ACC Seperex Nutritional Ltd

Total 45,704

Postgraduate Students PHYSIOTHERAPY Total Head Count 2009 2010

PhD 22 23

Masters† 9 11 † thesis or dissertation students only

Awards and Scholarships

Year Researcher Award/Scholarship

2010 Dr Margot Skinner Life Membership to the New Zealand Society of Physiotherapists

Division of HEALTH SCIENCES 101 COLLABORATIONS WITH EXTERNAL ORGANISATIONS

The Division has many diverse collaborations and affiliations with organisations external to the University of Otago. A selection is provided below.

• Centre for Bioengineering and Nanomedicine This centre is an initiative that has been supported by the TEC’s Priorities for Focus fund. The centre brings together researchers from across the Division’s campuses together with researchers from the Division of Sciences who have interests in imaging, biomaterials, tissue engineering, medical devices and process engineering in pharmacy. Since its establishment in 2010 the centre has already forged a number of external linkages with industry and has hosted a number of workshops with local stakeholders including CRIs and business. The centre has two hubs: ~ Dunedin: http://bioengineering.ac.nz/ ~ Christchurch http://bioengineering.ac.nz/OUC

• New Zealand Genomics Limited: www.otago.ac.nz/nzgl/otago008100.html This Divisionally led consortium was formally established in 2010 and is providing a collaborative national infrastructure in high throughput sequencing designed to accelerate New Zealand’s genomic research. Dr Tony Lough, with a PhD in Biochemistry from Otago and an MBA from Auckland, was appointed as the first CEO. All New Zealand’s major universities and seven Crown Research Institutes have given their support to the infrastructure. The lead institutions are the University of Otago, AgResearch, Massey University and the University of Auckland.

• Partnering for Innovation: In 2000 and 2010, a Divisional initiative funded by the TEC’s Encouraging and Supporting Innovation Fund, was launched to help facilitate development and translation of research to support and grow new science based industries. This University-wide programme was run in conjunction with the Universities of Canterbury and Lincoln and has resulted in significant collaboration towards these goals.

Other Relationships

• Other significant relationships exist with: ~ Faculty of Medical and Health Sciences, University of Auckland ~ Ngäi Tahu and other Iwi ~ District Health Boards, especially the Sothern DHB, Canterbury, Capital Coast, and Hutt Valley

~ Government Departments: - Ministry of Health - Ministry for Social Development - Ministry for Science and Innovation - Department of Corrections - ACC - New Zealand Trade and Enterprise

~ Crown Research Institutes where the Division holds a FRST subcontract: - AgResearch - Cawthorn Institute - ESR, Environmental Science and Research - IRL, Industrial Research Limited - NIWA, National Institute of Water and Atmospheric Research - Plant and Food New Zealand

• Centres of Research Excellence: Divisional staff are listed as Principal or Associate Investigators in the following national Centres of Research Excellence: ~ National Research Centre for Growth and Development (Auckland University) - Professor Ian Morison, DSM - Professor Christine Winterbourn, UOC - Associate Professor Mark Hampton, UOC - Associate Professor Peter Dearden, OSMS - Dr Elizabeth Duncan, OSMS

102 RESEARCH REPORT 2009/2010 ~ Maurice Wilkins Centre for Molecular Biodiscovery (Auckland University) - Dr Mik Black, OSMS - Professor Gregory Cook, OSMS - Associate Professor John Cutfield, OSMS - Associate Professor Catherine Day, OSMS - Professor Mike Eccles, DSM - Professor Dave Grattan, OSMS - Dr Mark Hampton, UOC - Dr Sarah Hook, Pharmacy - Professor Kurt Krause, OSMS - Professor Andrew Mercer, OSMS - Professor Thomas Rades, Pharmacy - Dr Joel Tyndall, Pharmacy - Dr Sarah Young, DSM

~ The MacDiarmid Institute for Advanced Materials and Nanotechnology (Canterbury and Victoria Universities) - Associate Professor John Evans, UOC

• International connectivity It is impossible to track accurately all collaborations with organisations and countries as most members of staff have numerous national and international connections. The USA, EU, South-East Asia, Japan and Australia account for the majority of international Divisional collaborations.

• William Evans Fellowships The Division hosted ten international researchers on William Evans Fellowships during 2009-10.

Division of HEALTH SCIENCES 103 RESEARCH SUPPORT SERVICES

The Division hosts the following research support services:

Anatomy Museum and Human Skeletal Collection The W.D. Trotter Anatomy Museum in the Department of Anatomy and Structural Biology was established in 1874 and holds a large collection of anatomical specimens and models, many of which date back to the late 1800s. The Museum also holds many osteological specimens and an extensive collection of normal and abnormal radiographs.

The Department has a well-equipped plastination laboratory which provides many of the new material for the Museum’s collections. A number of plastination techniques are undertaken including the silicone technique for plastinated prosections, E12 for transparent body slices, and P35 for thin brain slices.

The Department’s anthropological collection of human skeletal material is the largest in New Zealand. Postgraduate students and staff from any department in the University may apply for research-based access to the Museum and skeletal collections. http://anatomy.otago.ac.nz

Biomechanics Laboratory The cutting-edge Motion Analysis [Motion Analysis Corporation, Santa Rosa, CA] system in the Biomechanics Laboratory provides clinicians, researchers, coaches and industry with an accurate description of how a person moves during sporting, workplace or everyday activities. Force plates provide information on external ground reaction forces while electromyography provides information in the temporal sequencing of muscle activity in the generation of movement. This equipment can capture data on motion, ground reaction forces and the electrical activity of underlying muscles. http://physio.otago.ac.nz// facilities/biomech/equipment.html

Biostatistical and Bioinformatics Services The Division and Schools provide professional Biostatistical Services that are available across the three campuses. Individual arrangements for accessing the services exist in each School.

Bioinformatics expertise and advice is available through the Department of Biochemistry, especially those problems pertaining to microarray data (contact: Dr Mik Black [email protected]). From 2011, additional services will be available from NZGL, see below.

Centre for Protein Research The Centre for Protein Research is a facility strongly supported by the Departments of Biochemistry and Microbiology and Immunology but available to all researchers within the University of Otago. It combines both a service facility and a user laboratory that supports research projects largely within the Division of Health Sciences. The centre also provide service analyses for external institutes.

The facility is equipped with contemporary technologies for protein and proteome analyses such as MALDI tandem Time of Flight and ESI-coupled LTQ-Orbitrap mass spectrometry, different HPLC-systems for peptide and protein separation and large scale 2-D gel electrophoresis. http://biochem.otago.ac.nz/cpr/home.html

Histology Unit The Division houses the Pathology Anatomy Histology Unit (PAHU). The Unit provides histology services for University researchers as well as outside companies. It also offers diagnostic dental services for the country. The Unit undertakes processing, cutting and staining of all types of tissue. Routine staining, immunoperoxidase and fluorescent techniques are all catered for. Qualified Medical Laboratory Scientists are available to advise on all aspects of histology and to instruct users in either staining techniques or use of equipment. Equipment available for use includes: a cryostat, an embedding machine, a microtome, staining machines and a light microscope.

Contact: Mandy Fisher, Department of Pathology [email protected] Lynda Horne, School of Dentistry [email protected]

Laser Capture Microdissection Laser Capture Microdissection (LCM) is a method for isolating pure cells of interest from specific microscopic regions of tissue sections. Isolated cells can be used for downstream reactions such as RNA extraction for gene analysis, or protein extraction and analysis.

Primary contact person: Andrew McNaughton, ext 7308, B01g LFB. For online bookings: http://ocem.otago.ac.nz/Confocal/IndexConfocal.html

104 RESEARCH REPORT 2009/2010 New Zealand Genomics Limited (NZGL) Several of the country’s universities and Crown Research Institutes are pooling their resources in a collaborative national infrastructure designed to accelerate New Zealand’s genomic research and technology. Otago has led this initiative. From 2011, as part of the transition to a single genomics service facility on the Dunedin campus, the GS-FLX sequencing service offered by the University of Otago High Throughput DNA Sequencing Unit has ceased. A new service has now commenced as part of (NZGL). The Otago Genomics microarray facility will also transfer its activities to this new company in 2011. www.otago.ac.nz/nzgl

Otago Centres for Electron and Confocal Microscopy The Otago Centre for Electron Microscopy (OCEM) is well-equipped for all conventional electron microscopy applications. The Centre specialises in a range of cryopreparation techniques (both transmission electron microscopy and scanning electron microscopy) and immunocytochemical techniques.

There are two transmission electron microscopes, a Phillips CM 100TM and a Phillips 410LS TEM. The scanning electron microscopes are a JEOL 6700f field emission scanning electron microscope and a Cambridge S360 conventional SEM. The JEOL 6700f is fitted with an Alto 2500 high resolution cryostage for working with frozen hydrated specimens, and an elemental analysis (EDS) system.

The Otago Centre for Confocal Microscopy (OCCM) works in close association with the OCEM. It has two Zeiss LSM 510 confocal laser scanning microscopes: one configured for fixed, slide mounted material, the other for live cell investigations. Both are also capable of phase contrast, DIC, brightfield and fluorescence microscopy. There is an Olympus AX70 research grade microscope: configured for brightfield, phase contrast, darkfield and fluorescence microscopy. It is fitted with a Spot RT 5 megapixel camera and associated software for digital image capture

In addition, there is an Olympus FV1000 confocal laser scanning microscope which is configured to extend the range of experimental procedures, particularly those in the shorter excitation range. The Centre also has a UMIS, nano-indenter system which augments hard tissue morphology data by quantifying its physical attributes, and a SkyScan 7200 high resolution micro CT scanner. http://ocem.otago.ac.nz/

Otago Flow Cytometry Facility The Flow Cytometry (FACS) Facility provides the University of Otago with fluorescent cell analysis and sorting, magnetic bead separation and fluorescent protein detection technology. The facility is situated in two locations on the campus. Two analysers and the fluorescent and magnetic bead based cell sorters, are housed within the Department of Microbiology and Immunology. The other analyser is housed within the Wellcome Institute. In addition the facility offers a Bioplex machine that allows researchers to simultaneously analyse multiple analytes, such as cytokines, within biological samples. These can be used for the analysis of complex cell suspensions: (blood cells, bacterial communities, disaggregated tumours, cell cycle analysis).

Contact Dr Alex McLellan: [email protected]

Protein Crystallography Facility Professor Krause serves as the Director of the protein crystallography facility within the Division. The facility consists of three large temperature controlled rooms. One is devoted to crystallisation and contains a new MosquitoTM crystallisation robot. The second room contains computer control and modelling facilities. The third room contains a MicroMax007HF with an R-axis IV++ area detector. It is equipped with both chromium and copper anodes and separate optics. Chromium radiation is used for single wavelength anomalous diffraction (SAD) determination of protein structures, mitigating in most cases the need to visit a synchrotron. This approach has been effective for proteins with 2% or more S or Se containing residues. The flux of this machine is roughly equivalent to the protein crystallography beamline at the LSU- CAMD synchrotron facility in Baton Rouge, La. Cryo-cooling is carried out using a Rigaku X-stream 2000 cooling system. The University is also part of a consortium that will have regular access to the protein beamlines at the Australia National Synchrotron in Melbourne. Beamlines there will be optimised for MAD structure determination and native data collection.

Researchers interested in pursuing a protein crystal structure determination should email Professor Krause at: [email protected]

Real Time PCR Real time PCR is available at a number of sites throughout the Division, including the Department of Pathology at the Dunedin School of Medicine, the Otago School of Medical Sciences, the Sir John Walsh Research Institute in Dentistry, and at University of Otago, Christchurch

Division of HEALTH SCIENCES 105 DIVISIONAL SUPPORT FOR RESEARCH

The Division has a Research Committee, consisting of the Associate Deans of Research from each School plus other representatives. This Committee meets four or more times annually and controls an annual budget which provides:

• Postdoctoral Fellowships • PhD conference travel funding • An annual Divisional Research Forum • Mentoring for targeted grant applications • Review of applications • Oversight of PBRF Evidence Portfolio preparation • Research workshops • Other support as decided

The Committee is Chaired by the Division’s Associate Dean for Research, Professor Warren Tate. The Division employs Dr Michele Coleman as its Research and Development Manager and Dr Kerry Galvin to support research.

For further information please contact: [email protected]

106 RESEARCH REPORT 2009/2010 UNIVERSITY OF OTAGO RESEARCH AND ENTERPRISE OFFICE

The Research and Enterprise Office deals with research funding and assists researchers in gaining funding from the application/proposal stage right through to contracting and reporting stages. Research and Enterprise staff provide the liaison between the funding bodies, industry or businesses and staff at the University. The Research and Enterprise Office deal with a range of activities including: ~ Research grants, proposals and contracts (externally funded travel and equipment grants) ~ Fellowships ~ University of Otago Research Grants ~ Technology transfer ~ Intellectual property protection (including patents and trademarks) ~ Material transfer agreements

Under the auspices of the Research and Enterprise Office, research in the Division of Health Sciences is supported by a number of Research Advisors and Administrators, and additional staff at the University of Otago, Christchurch and Wellington.

Staff with Health Sciences Responsibilities:

Christine Groves, Research Advisor University of Otago, Wellington [email protected]

Virginia Irvine, Research Manager University of Otago, Christchurch [email protected]

Karen Chaney, Research Advisor University of Otago, Christchurch [email protected]

Dayle Matthews, Manager Health Research Office, Dunedin School of Medicine [email protected]

Ali Cameron, Research Advisor Health Research Office, Dunedin School of Medicine [email protected]

Dr Edwin Meijerink, Research Advisor Health Research Office, Dunedin School of Medicine [email protected]

Ruth Sharpe, Clinical Research Advisor Health Research Office, Dunedin School of Medicine [email protected]

Dr Natalie Harfoot, Research Advisor (Health Sciences) Research and Enterprise Office, Dunedin [email protected]

Dr Eric Lord, Research Advisor (Health Sciences) Research and Enterprise Office, Dunedin [email protected]

David Grimmett, Enterprise Manager [email protected]

Ruth Appleby, Enterprise Manager [email protected]

Division of HEALTH SCIENCES 107 APPENDIX 1: PUBLICATIONS BY DEPARTMENT 2009 - 2010

FACULTY OF DENTISTRY DEPARTMENT OF ORAL DIAGNOSTIC AND SURGICAL SCIENCES

Chapter in Book - Research Love, R. M. (2009). Mircrobiology of caries and dentinal tubule infection. In A. F. Fouad (Ed.), Endodontic Microbiology (pp. 22-39). Ames, IA: Wiley-Blackwell.

Journal - Research Article Alsabeeha, N. H. M., De Silva, R. K., Thomson, W. M., & Payne, A. G. T. (2010). Primary stability measurements of single implants in the midline of the edentulous mandible for overdentures. Clinical Oral Implants Research, 21, 563-566. doi: 10.1111/j.1600-0501.2009.01890.x Alsabeeha, N. H. M., Payne, A. G. T., De Silva, R. K., & Thomson, W. M. (2010). Mandibular single-implant overdentures: Preliminary results of a randomised-control trial on early loading with different implant diameters and attachment systems. Clinical Oral Implants Research, Advance Online Publication. doi: 10.1111/j.1600-0501.2010.02004.x Alsabeeha, N., Payne, A. G. T., De Silva, R. K., & Swain, M. V. (2009). Mandibular single-implant overdentures: A review with surgical and prosthodontic perspectives of a novel approach. Clinical Oral Implants Research, 20(4), 356-365. doi: 10.1111/j.1600-0501.2008.01666.x Atieh, M. A., Payne, A. G. T., Duncan, W. J., de Silva, R. K., & Cullinan, M. P. (2010). Immediate placement or immediate restoration/loading of single implants for molar tooth replacement: A systematic review and meta-analysis. International Journal of Oral and Maxillofacial Implants, 25(2), 401-415. Ayers, K. M. S., Thomson, W. M., Newton, J. T., Morgaine, K. C., & Rich, A. M. (2009). Self-reported occupational health of general dental practitioners. Occupational Medicine, 59(3), 142-148. doi: 10.1093/occmed/kqp004 Becconsall-Ryan, K., Tong, D., & Love, R. (2010). Radiolucent inflammatory jaw lesions: A twenty-year analysis. International Endodontic Journal, 43, 859-865. doi: 10.1111/j.1365-2591.2010.01751.x Campbell, D. I., Kuzmanovic, D., & DeSilva, R. K. (2010). Bimaxillary osteotomy in a young, edentulous patient with LADD syndrome. Journal of Oral and Maxillofacial Surgery, 68(7), 1685-1690. doi: 10.1016/j.joms.2009.07.095 Desai, S. V., Love, R. M., Rich, A. M., & Seymour, G. J. (2010). Antigen recognition and presentation in periapical tissues: A role for TLR expressing cells? International Endodontic Journal, Advance Online Publication. doi: 10.1111/j.1365- 2591.2010.01817.x Friedlander, L. T., Cullinan, M. P., & Love, R. M. (2009). Dental stem cells and their potential role in apexogenesis and apexification. International Endodontic Journal, 42(11), 955-962. doi: 10.1111/j.1365-2591.2009.01622.x Kaur, J., Hay, K. D., Macdonald, H., & Rich, A. M. (2009). Retrospective audit of the use of the Marx Protocol for prophylactic hyperbaric oxygen therapy in managing patients requiring dental extractions following radiotherapy to the head and neck. New Zealand Dental Journal, 105(2), 47-50. Kuzmanovic, D., & Lyons, K. M. (2009). Tooth shade selection using a colorimetric instrument compared with that using a conventional shade guide. New Zealand Dental Journal, 105(4), 131-134. Love, R. M., & Firth, N. (2009). Histopathological profile of surgically removed persistent periapical radiolucent lesions of endodontic origin. International Endodontic Journal, 42(3), 198-202. doi: 10.1111/j.1365-2591.2008.01500.x Naidoo, R. J., De Silva, H. L., & Tong, D. C. (2009). Full frontal: Considerations in a 16-year-old rugby player with a frontal sinus fracture. New Zealand Dental Journal, 105(2), 51-55. Ng, L. K., Rich, A. M., Hussaini, H. M., Thomson, W. M., Fisher, A., Horne, L., & Seymour, G. J. (2010). Toll-like receptor 2 is present in the microenvironment of oral squamous cell carcinoma. British Journal of Cancer, Advance Online Publication. doi: 10.1038/sj.bjc.6606057 Niimi, M., Firth, N. A., & Cannon, R. D. (2010). Antifungal drug resistance of oral fungi. Odontology, 98(1), 15-25. doi: 10.1007/s10266-009-0118-3 Nolan, A., Badminton, J., Maguire, J., & Seymour, R. A. (2009). The efficacy of topical hyaluronic acid in the management of oral lichen planus. Journal of Oral Pathology & Medicine, 38, 299-303. doi: 10.1111/j.1600-0714.2008.00739.x Reith, D., Medlicott, N. J., Kumara De Silva, R., Yang, L., Hickling, J., & Zacharias, M. (2009). Simultaneous modelling of the Michaelis-Menten kinetics of paracetamol sulphation and glucuronidation. Clinical and Experimental Pharmacology and Physiology, 36(1), 35-42. doi: 10.1111/j.1440-1681.2008.05029.x Rosdy, N. M. M. N. M., Firth, N. A., & Rich, A. M. (2010). Calibre-persistent labial artery: Often misdiagnosed as a mucocoele. International Journal of Oral and Maxillofacial Surgery, Advance Online Publication. doi: 10.1016/j.ijom.2010.05.003 Tong, D. C., Kumar, R. R., Kok, S., De Silva, R. K., & Thomson, W. M. (2010). Patterns of maxillofacial fracture presentation in Dunedin from 2000 to 2005. New Zealand Dental Journal, 106(1), 16-19. Tong, D., Dawson, J., & Love, R. (2010). Factors affecting oral health status in an elderly military veteran population in New Zealand. Journal of Military Veterans’ Health, 18(3), 12-17. Verma, P., & Love, R. M. (2010). A Micro CT study of the mesiobuccal root canal morphology of the maxillary first molar tooth. International Endodontic Journal, Advance Online Publication. doi: 10.1111/j.1365-2591.2010.01800.x Willis, D. H. R., Tong, D. C., Thomson, W. M., & Love, R. M. (2010). Maxillofacial trauma and the GDP: Speciality recognition and patterns of referral. New Zealand Dental Journal, 106(3), 97-102.

108 RESEARCH REPORT 2009/2010 Zhang, N., Upritchard, J. E., Holland, B. R., Fenton, L. E., Ferguson, M. M., Cannon, R. D., & Schmid, J. (2009). Distribution of mutations distinguishing the most prevalent disease-causing Candida albicans genotype from other genotypes. Infection, Genetics & Evolution, 9(4), 493-500. doi: 10.1016/j.meegid.2009.01.007 Zhou, J., Paul, A., Bennani, V., Thomson, W. M., & Firth, N. (2010). New Zealand dental practitioners’ experience of patient allergies to dental alloys used for prosthodontics. New Zealand Dental Journal, 106(2), 55-60.

Journal - Research Other Nolan, A. (2009). [Commentary on the article Interventions for prevention and treatment of herpes simplex virus in cancer patients]. Evidence Based Dentistry, 10(4), 116-117. doi: 10.1038/sj.ebd.6400689

FACULTY OF DENTISTRY DEPARTMENT OF ORAL REHABILITATION

Chapter in Book - Research Cannon, R. D., Lyons, K. M., Chong, K., & Holmes, A. R. (2010). Adhesion of yeast and bacteria to oral surfaces. In G. J. Seymour, M. P. Cullinan & N. C. K. Heng (Eds.), Oral Biology (pp. 103-124). New York: Springer. doi: 10.1007/978-1- 60761-820-1_8

Chapter in Book - Other Chandler, N. P. (2010). Root canal filling. In B. S. Chong (Ed.), Harty’s endodontics in clinical practice (6th ed.). (pp. 131-157). Edinburgh, UK: Churchill Livingstone. doi: 10.1016/B978-0-7020-3156-4.00012-7

Journal - Research Article Abduo, J., Bennani, V., Waddell, J. N., Lyons, K., & Swain, M. (2010). Assessing the fit of implant fixed prostheses: A critical review. International Journal of Oral & Maxillofacial Implants, 25(3), 506-515. Abduo, J., Lyons, K., & Swain, M. (2010). Fit of zirconia fixed partial denture: A systematic review. Journal of Oral Rehabilitation, 37(11), 866-876. doi: 10.1111/j.1365-2842.2010.02113.x Al-Amleh, B., Lyons, K., & Swain, M. (2010). Clinical trials in zirconia: A systematic review. Journal of Oral Rehabilitation, 37(8), 641-652. doi: 10.1111/j.1365-2842.2010.02094.x Al-Ani, A., Bennani, V., Chandler, N. P., Lyons, K. M., & Thomson, W. M. (2010). New Zealand dentists’ use of gingival retraction techniques for fixed prosthodontics and implants. New Zealand Dental Journal, 106(3), 92-96. Allsobrook, O. F. L., Leichter, J., Holborow, D., & Swain, M. (2009). Descriptive study of the longevity of dental implant surgery drills. Clinical Implant Dentistry and Related Research, Advance Online Publication. doi: 10.1111/j.1708- 8208.2009.00205.x Alsabeeha, N., Atieh, M., Swain, M. V., & Payne, A. G. T. (2010). Attachment systems for mandibular single-implant overdentures: An in vitro retention force investigation on different designs. International Journal of Prosthodontics, 23(2), 160-166. Alsabeeha, N. H. M., De Silva, R. K., Thomson, W. M., & Payne, A. G. T. (2010). Primary stability measurements of single implants in the midline of the edentulous mandible for overdentures. Clinical Oral Implants Research, 21, 563-566. doi: 10.1111/j.1600-0501.2009.01890.x Alsabeeha, N. H. M., Payne, A. G. T., De Silva, R. K., & Thomson, W. M. (2010). Mandibular single-implant overdentures: Preliminary results of a randomised-control trial on early loading with different implant diameters and attachment systems. Clinical Oral Implants Research, Advance Online Publication. doi: 10.1111/j.1600-0501.2010.02004.x Alsabeeha, N., Payne, A. G. T., De Silva, R. K., & Swain, M. V. (2009). Mandibular single-implant overdentures: A review with surgical and prosthodontic perspectives of a novel approach. Clinical Oral Implants Research, 20(4), 356-365. doi: 10.1111/j.1600-0501.2008.01666.x Al-Zubeidi, M. I., Alsabeeha, N. H. M., Thomson, W. M., & Payne, A. G. T. (2010). Patient satisfaction and dissatisfaction with mandibular two-implant overdentures using different attachment systems: 5-year outcomes. Clinical Implant Dentistry and Related Research, Advance Online Publication. doi: 10.1111/j.1708-8208.2010.00306.x Ang, S. F., Bortel, E. L., Swain, M. V., Klocke, A., & Schneider, G. A. (2010). Size-dependent elastic/inelastic behavior of enamel over millimeter and nanometer length scales. Biomaterials, 31(7), 1955-1963. doi: 10.1016/j.biomaterials.2009.11.045 Atieh, M. A. H., Payne, A. G. T., & Duncan, W. J. (2009). Immediate loading with single implant crowns: A systematic review and meta-analysis. International Journal of Prosthodontics, 22(4), 378-387. Atieh, M. A., Ibrahim, H. M., & Atieh, A. H. (2010). Platform switching for marginal bone preservation around dental implants: A systematic review and meta-analysis. Journal of Periodontology, 81(10), 1350-1366. doi: 10.1902/ jop.2010.100232 Atieh, M. A., Payne, A. G. T., Duncan, W. J., & Cullinan, M. P. (2009). Immediate restoration/loading of immediately placed single implants: Is it an effective bimodal approach? Clinical Oral Implants Research, 20(7), 645-659. doi: 10.1111/j.1600- 0501.2009.01725.x Atieh, M. A., Payne, A. G. T., Duncan, W. J., de Silva, R. K., & Cullinan, M. P. (2010). Immediate placement or immediate restoration/loading of single implants for molar tooth replacement: A systematic review and meta-analysis. International Journal of Oral and Maxillofacial Implants, 25(2), 401-415.

Division of HEALTH SCIENCES 109 Bennani, V., & Shahmiri, R. (2009). A simple method to transfer the selected path of insertion of a removable partial denture intraorally. Journal of Prosthetic Dentistry, 101(1), 73-74. doi: 10.1016/S0022-3913(08)60295-4 Chandler, N. P., Pitt Ford, T. R., & Monteith, B. D. (2010). Effect of restorations on pulpal blood flow in molars measured by laser doppler flowmetry. International Endodontic Journal, 43(1), 41-46. doi: 10.1111/j.1365-2591.2009.01630.x Desai, S., & Chandler, N. (2009). Calcium hydroxide-based root canal sealers: A review. Journal of Endodontics, 35(4), 475-480. doi: 10.1016/j.joen.2008.11.026 Desai, S., & Chandler, N. (2009). The restoration of permanent immature anterior teeth, root filled using MTA: A review. Journal of Dentistry, 37(9), 652-657. doi: 10.1016/j.jdent.2009.05.026 Desai, S. V., Love, R. M., Rich, A. M., & Seymour, G. J. (2010). Antigen recognition and presentation in periapical tissues: A role for TLR expressing cells? International Endodontic Journal, Advance Online Publication. doi: 10.1111/j.1365- 2591.2010.01817.x Dias, G. J., Mahoney, P., Swain, M., Kelly, R. J., Smith, R. A., & Ali, M. A. (2010). Keratin-hydroxyapatite composites: Biocompatibility, osseointegration, and physical properties in an ovine model. Journal of Biomedical Materials Research: Part A, Advance Online Publication. doi: 10.1002/jbm.a.32908 Farah, R. A., Monk, B. C., Swain, M. V., & Drummond, B. K. (2010). Protein content of molar-incisor hypomineralisation enamel. Journal of Dentistry, 38, 591-596. doi: 10.1016/j.jdent.2010.04.012 Farah, R. A., Swain, M. V., Drummond, B. K., Cook, R., & Atieh, M. (2010). Mineral density of hypomineralised enamel. Journal of Dentistry, 38(1), 50-58. doi: 10.1016/j.jdent.2009.09.002 Farah, R., Drummond, B. K., Swain, M., & Williams, S. (2010). Linking the clinical presentation of molar-incisor hypomineralisation to its mineral density. International Journal of Paediatric Dentistry, 20(5), 353-360. doi: 10.1111/j.1365- 263X.2010.01061.x Field, C., Ichim, I., Swain, M. V., Chan, E., Darendeliler, M. A., Li, W., & Li, Q. (2009). Mechanical responses to orthodontic loading: A 3-dimensional finite element multi-tooth model. American Journal of Orthodontics and Dentofacial Orthopedics, 135(2), 174-181. doi: 10.1016/j.ajodo.2007.03.032 Foster Page, L. A. (2009). Retrospective audit of Taranaki children undergoing dental care under general anaesthetic from 2001 to 2005. New Zealand Dental Journal, 105(1), 9-13. Friedlander, L. T., Cullinan, M. P., & Love, R. M. (2009). Dental stem cells and their potential role in apexogenesis and apexification. International Endodontic Journal, 42(11), 955-962. doi: 10.1111/j.1365-2591.2009.01622.x Gowda, S., Thomson, W. M., Foster Page, L. A., & Croucher, N. A. (2009). What difference does using bitewing radiographs make to epidemiological estimates of dental caries prevalence and severity in a young adolescent population with high caries experience? Caries Research, 43(6), 436-441. doi: 10.1159/000252977 Guidoni, G. M., He, L. E., Schöberl, T., Jäger, I., Dehm, G., & Swain, M. V. (2009). Influence of the indenter tip geometry and environment on the indentation modulus of enamel. Journal of Materials Research, 24(3), 616-625. doi: 10.1557/ jmr.2009.0110 Guidoni, G. M., Swain, M. V., & Jäger, I. (2009). Wear behaviour of dental enamel at the nanoscale with a sharp and blunt indenter tip. Wear, 266(1-2), 60-68. doi: 10.1016/j.wear.2008.05.007 Guidoni, G., Swain, M., & Jäger, I. (2010). Nano-scale sliding contact deformation behaviour of enamel under wet and dry conditions. Journal of Materials Science: Materials in Medicine, 21(4), 1195-1203. doi: 10.1007/s10856-010-3988-6 He, L-H., Jansen van Vuuren, L., Planitz, N., & Swain, M. V. (2010). A micro-mechanical evaluation of the effects of die hardener on die stone. Dental Materials Journal, 29(4), 433-437. doi: 10.4012/dmj.2009-094 He, L-H., Purton, D. G., & Swain, M. V. (2010). A suitable base material for composite resin restorations: Zinc oxide eugenol. Journal of Dentistry, 38, 290-295. doi: 10.1016/j.jdent.2009.11.009 He, L-H., & Swain, M. V. (2009). Enamel: A functionally graded natural coating. Journal of Dentistry, 37, 596-603. doi: 10.1016/j.jdent.2009.03.019 He, L-H., Xu, Y., & Purton, D. G. (2010). In vitro demineralisation of the cervical region of human teeth. Archives of Oral Biology, Advance Online Publication. doi: 10.1016/j.archoralbio.2010.11.009 Huang, T. T. Y., He, L-H., Darendeliler, M. A., & Swain, M. V. (2010). Correlation of mineral density and elastic modulus of natural enamel white spot lesions using x-ray micro-tomography and nano-indentation. Acta Biomaterialia, Advance Online Publication. doi: 10.1016/j.actbio.2010.06.028 Jörn, D., Waddell, J. N., & Swain, M. V. (2010). The influence of opaque application methods on the bond strength and final shade of PFM restorations. Journal of Dentistry, 38S(Suppl. 2), e143-e149. doi: 10.1016/j.jdent.2010.08.016 Kennedy, D., Kieser, J., Bolter, C., Swain, M., Singh, B., & Waddell, J. N. (2010). Tongue pressure patterns during water swallowing. Dysphagia, 25, 11-19. doi: 10.1007/s00455-009-9223-2 Kuzmanovic, D., & Lyons, K. M. (2009). Tooth shade selection using a colorimetric instrument compared with that using a conventional shade guide. New Zealand Dental Journal, 105(4), 131-134. Ma, S., & Payne, A. G. T. (2010). Marginal bone loss with mandibular two-implant overdentures using different loading protocols: A systematic literature review. International Journal of Prosthodontics, 23(2), 117-126. Ma, S., Tawse-Smith, A., Thomson, W. M., & Payne, A. G. T. (2010). Marginal bone loss with mandibular two-implant overdentures using different loading protocols and attachment systems: 10-year outcomes. International Journal of Prosthodontics, 23(4), 321-332. Mencík,ˇ J., He, L. H., & Nemecek,ˇ ˇ J. (2010). Characterization of viscoelastic-plastic properties of solid polymers by instrumented indentation. Polymer Testing, Advance Online Publication. doi: 10.1016/j.polymertesting.2010.11.006

110 RESEARCH REPORT 2009/2010 Mencik,ˇ J., He, L. H., & Swain, M. V. (2009). Determination of viscoelastic-plastic material parameters of biomaterials by instrumented indentation. Journal of the Mechanical Behavior of Biomedical Materials, 2(4), 318-325. doi: 10.1016/j. jmbbm.2008.09.002 Park, C., Swain, M., & Duncan, W. (2010). Micro-computerised tomography optimisation for the measurement of bone mineral density around titanium dental implants. Journal of Biomechanical Science and Engineering, 5(1), 2-10. doi: 10.1299/jbse.5.2 Payne, A., Walton, J., Alsabeeha, N., Worthington, H. V., & Esposito, M. (2009). Interventions for replacing missing teeth: Attachment systems for implant overdentures in edentulous jaws. Cochrane Database of Systematic Reviews, 4, CD008001. doi: 10.1002/14651858.CD008001 Purton, D. G., Chandler, N. P., Monteith, B. D., & Qualtrough, A. J. (2009). A novel instrument to determine pulp proximity. European Journal of Prosthodontics and Restorative Dentistry, 17(1), 30-34. doi: 10.1922/EJPRD_761Purton05 Radford, G., Kieser, J., Bernal, V., Waddell, J. N., & Forrest, A. (2009). Biomechanical approach to human bitemark reconstruction. Journal of Forensic Odonto-Stomatology, 27(1), 33-36. Rose, D., Quick, A., Swain, M., & Herbison, P. (2009). Moment-to-force characteristics of preactivated nickel-titanium and titanium-molybdenum alloy symmetrical T-loops. American Journal of Orthodontics and Dentofacial Orthopedics, 135(6), 757-763. doi: 10.1016/j.ajodo.2007.06.015 Röhrle, O., Waddell, J. N., Foster, K. D., Saini, H., & Pullan, A. J. (2009). Using a motion-capture system to record dynamic articulation for application in CAD/CAM software. Journal of Prosthodontics, 18(8), 703-710. doi: 10.1111/j.1532- 849X.2009.00510.x Saini, H., Waddell, J. N., Pullan, A. J., & Röhrle, O. (2009). Automatically generating subject-specific functional tooth surfaces using virtual mastication. Annals of Biomedical Engineering, 37(8), 1646-1653. doi: 10.1007/s10439-009-9725-y Scherrer, S. S., Cesar, P. F., & Swain, M. V. (2010). Direct comparison of the bond strength results of the different test methods: A critical literature review. Dental Materials, 26(2), e78-e93. doi: 10.1016/j.dental.2009.12.002 Schwass, D. R., Swain, M. V., Purton, D. G., & Leichter, J. W. (2009). A system of calibrating microtomography for use in Caries Research. Caries Research, 43(4), 314-321. doi: 10.1159/000226230 Shahmiri, R. A., & Atieh, M. A. (2010). Mandibular Kennedy Class 1 implant-tooth-borne removable partial denture: A systematic review. Journal of Oral Rehabilitation, 37(3), 225-234. doi: 10.1111/j.1365-2842.2009.02044.x Swain, M. V. (2009). Unstable cracking (chipping) of veneering porcelain on all-ceramic dental crowns and fixed partial dentures. Acta Biomaterialia, 5(5), 1668-1677. doi: 10.1016/j.actbio.2008.12.016 Traebert, J., de Lacerda, J. T., Thomson, W. M., Foster Page, L., & Locker, D. (2010). Differential item functioning in a

Brazilian-Portuguese version of the Child Perceptions Questionnaire (CPQ11-14). Community Dentistry and Oral Epidemiology, 38(2), 129-135. doi: 10.1111/j.1600-0528.2009.00525.x Traebert, J., Foster Page, L. A., Thomson, W. M., & Locker, D. (2010). Differential item functioning related to ethnicity in an oral health-related quality of life measure. International Journal of Paediatric Dentistry, 20(6), 435-441. doi: 10.1111/j.1365-263X.2010.01066.x Violich, D. R., & Chandler, N. P. (2010). The smear layer in endodontics: A review. International Endodontic Journal, 43(1), 2-15. doi: 10.1111/j.1365-2591.2009.01627.x Waddell, J. N., Girvan, L., Aarts, J. M., Wu, W., & Swain, M. V. (2010). Elemental composition of imported porcelain-fused-to- metal crowns: A pilot study. New Zealand Dental Journal, 106(2), 50-54. Waddell, J. N., Payne, A. G. T., & Kieser, J. A. (2010). Scanning electron microscopy observations of failures of implant overdenture bars: A case series report. Clinical Implant Dentistry and Related Research, 12(1), 26-38. doi: 10.1111/j.1708- 8208.2008.00127.x Zhou, J., Paul, A., Bennani, V., Thomson, W. M., & Firth, N. (2010). New Zealand dental practitioners’ experience of patient allergies to dental alloys used for prosthodontics. New Zealand Dental Journal, 106(2), 55-60. Zou, W., Gao, J., Jones, A. S., Hunter, N., & Swain, M. V. (2009). Characterization of a novel calibration method for mineral density determination of dentine by X-ray micro-tomography. Analyst, 134, 72-79. doi: 10.1039/b806884d

Journal - Research Other Bennani, V., Schwass, D., & Chandler, N. (2009). Gingival retraction: Author’s response [Letter]. Journal of the American Dental Association, 140(2), 143-144. Purton, D. (2009). Most cited: Number 6: A comparison of the heat production and mechanical efficiency of diamond instruments, stones, and burs at 3,000 and 60,000 r.p.m. New Zealand Dental Journal, 105(3), 101-102. Siddiqi, A., Payne, A. G. T., & Zafar, S. (2009). Bisphosphonate-induced osteonecrosis of the jaw: A medical enigma? Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics, 108(3), e1-e8. doi: 10.1016/j.tripleo.2009.04.027 Zioupos, P., Cook, R. B., & Hutchinson, J. R. (2009). More thoughts on the relationship between apparent and material densities in bone [Letter to the editor]. Journal of Biomechanics, 42(6), 794-795. doi: 10.1016/j.jbiomech.2009.01.014

Division of HEALTH SCIENCES 111 FACULTY OF DENTISTRY DEPARTMENT OF ORAL SCIENCES

Edited Book - Research Seymour, G. J., Cullinan, M. P., & Heng, N. C. K. (Eds.). (2010). Oral Biology. New York: Springer, 360p.

Chapter in Book - Research Aziz, A., Parmar, D., McNaughton, A., & Tompkins, G. R. (2010). Bacterial viability determination in a dentinal tubule infection model by confocal laser scanning microscopy. In G. J. Seymour, M. P. Cullinan & N. C. K. Heng (Eds.), Oral Biology (pp. 141-150). New York: Springer. doi: 10.1007/978-1-60761-820-1_10 Butson, R., Cook, J. M., & Kardos, R. (2009). The oral health e-portfolio: A three-year project. In J. Zubizarreta (Ed.), The learning portfolio: Reflective practice for improving student learning (2nd ed.). (pp. 97-108). San Francisco, CA: Jossey-Bass. Cannon, R. D., Lyons, K. M., Chong, K., & Holmes, A. R. (2010). Adhesion of yeast and bacteria to oral surfaces. In G. J. Seymour, M. P. Cullinan & N. C. K. Heng (Eds.), Oral Biology (pp. 103-124). New York: Springer. doi: 10.1007/978-1- 60761-820-1_8 Chou, P., & Milne, T. J. (2010). Real-time PCR focused-gene array profiling of gingival and periodontal ligament fibroblasts. In G. J. Seymour, M. P. Cullinan & N. C. K. Heng (Eds.), Oral Biology (pp. 373-383). New York: Springer. doi: 10.1007/978-1- 60761-820-1_23 Heng, N. C. K., & Stanton, J-A. L. (2010). Oral bacterial genome sequencing using the high-throughput Roche Genome Sequencer FLX System. In G. J. Seymour, M. P. Cullinan & N. C. K. Heng (Eds.), Oral Biology (pp. 197-218). New York: Springer. doi: 10.1007/978-1-60761-820-1_14 Kieser, J. A., Tkatchenko, T., Dean, M. C., Jones, M. E. H., Duncan, W., & Nelson, N. J. (2009). Microstructure of dental hard tissues and bone in the tuatara dentary, Sphenodon punctatus (Diapsida: Lepidosauria: Rhynchocephalia). In T. Koppe, G. Meyer, & K. W. Alt (Eds.), Comparative dental morphology: Frontiers of Oral Biology (Vol. 13) (pp. 80-85). Basel, Switzerland: Karger. doi: 10.1159/000242396 Lamping, E., & Cannon, R. D. (2010). Use of a yeast-based membrane protein expression technology to overexpress drug resistance efflux pumps. In G. J. Seymour, M. P. Cullinan & N. C. K. Heng (Eds.), Oral Biology (pp. 219-250). New York: Springer. doi: 10.1007/978-1-60761-820-1_15 Lang, N. P., Cullinan, M. P., Holborow, D. W., & Heitz-Mayfield, L. J. A. (2010). Examiner training: Standardization and calibration in periodontal studies. In W. V. Giannobile, B. A. Burt & R. J. Genco (Eds.), Clinical reseach in oral health (pp. 159-176). Ames, IA: Blackwell. Michelotti, A., & Farella, M. (2010). Malocclusion and body posture. In D. Manfredini (Ed.), Current concepts on temporomandibular disorders (pp. 283-293). London: Quintessence. Palla, S., & Farella, M. (2010). Masticatory muscle pain. In S. Mense & R. D. Gerwin (Eds.), Muscle pain: Diagnosis and treatment (pp. 193-228). New York: Springer.

Journal - Research Article Al-Ani, A., Bennani, V., Chandler, N. P., Lyons, K. M., & Thomson, W. M. (2010). New Zealand dentists’ use of gingival retraction techniques for fixed prosthodontics and implants. New Zealand Dental Journal, 106(3), 92-96. Allsobrook, O. F. L., Leichter, J., Holborow, D., & Swain, M. (2009). Descriptive study of the longevity of dental implant surgery drills. Clinical Implant Dentistry and Related Research, Advance Online Publication. doi: 10.1111/j.1708- 8208.2009.00205.x Alsabeeha, N. H. M., De Silva, R. K., Thomson, W. M., & Payne, A. G. T. (2010). Primary stability measurements of single implants in the midline of the edentulous mandible for overdentures. Clinical Oral Implants Research, 21, 563-566. doi: 10.1111/j.1600-0501.2009.01890.x Alsabeeha, N. H. M., Payne, A. G. T., De Silva, R. K., & Thomson, W. M. (2010). Mandibular single-implant overdentures: Preliminary results of a randomised-control trial on early loading with different implant diameters and attachment systems. Clinical Oral Implants Research, Advance Online Publication. doi: 10.1111/j.1600-0501.2010.02004.x Al-Zubeidi, M. I., Alsabeeha, N. H. M., Thomson, W. M., & Payne, A. G. T. (2010). Patient satisfaction and dissatisfaction with mandibular two-implant overdentures using different attachment systems: 5-year outcomes. Clinical Implant Dentistry and Related Research, Advance Online Publication. doi: 10.1111/j.1708-8208.2010.00306.x Armitage, G. C., & Cullinan, M. P. (2010). Comparison of the clinical features of chronic and aggressive periodontitis. Periodontology 2000, 53(1), 12-27. doi: 10.1111/j.1600-0757.2010.00353.x Armitage, G. C., Cullinan, M. P., & Seymour, G. J. (2010). Comparative biology of chronic and aggressive periodontitis: Introduction. Periodontology 2000, 53(1), 7-11. doi: 10.1111/j.1600-0757.2010.00359.x Arroll, B., Dhar, D., & Cullinan, M. (2010). Relationship of root canal treatment to C-reactive protein as an inflammatory marker for cardiovascular disease. Journal of Primary Health Care, 2(1), 11-15. Atieh, M. A. H., Payne, A. G. T., & Duncan, W. J. (2009). Immediate loading with single implant crowns: A systematic review and meta-analysis. International Journal of Prosthodontics, 22(4), 378-387. Atieh, M. A., Payne, A. G. T., Duncan, W. J., & Cullinan, M. P. (2009). Immediate restoration/loading of immediately placed single implants: Is it an effective bimodal approach? Clinical Oral Implants Research, 20(7), 645-659. doi: 10.1111/j.1600- 0501.2009.01725.x

112 RESEARCH REPORT 2009/2010 Atieh, M. A., Payne, A. G. T., Duncan, W. J., de Silva, R. K., & Cullinan, M. P. (2010). Immediate placement or immediate restoration/loading of single implants for molar tooth replacement: A systematic review and meta-analysis. International Journal of Oral and Maxillofacial Implants, 25(2), 401-415. Ayers, K. M. S., Thomson, W. M., Newton, J. T., Morgaine, K. C., & Rich, A. M. (2009). Self-reported occupational health of general dental practitioners. Occupational Medicine, 59(3), 142-148. doi: 10.1093/occmed/kqp004 Blinkhorn, A., Bartold, P. M., Cullinan, M. P., Madden, T., Marshall, R. I., Raphael, S. L., & Seymour, G. J. (2009). Is there a role for triclosan/copolymer toothpaste in the management of periodontal disease? British Dental Journal, 207(3), 117-125. doi: 10.1038/sj.bdj.2009.669 Bohnstedt, S., Cullinan, M. P., Ford, P. J., Palmer, J. E., Leishman, S. J., Westerman, B., Marshall, R. I., West, M. J., & Seymour, G. J. (2010). High antibody levels to P. gingivalis in cardiovascular disease. Journal of Dental Research, 89(9), 938-942. doi: 10.1177/0022034510370817 Cannon, R. D., Lamping, E., Holmes, A. R., Niimi, K., Baret, P. V., Keniya, M. V., Tanabe, K., Niimi, M., Goffeau, A., & Monk, B. C. (2009). Efflux-mediated antifungal drug resistance. Clinical Microbiology Reviews, 22(2), 291-321. doi: 10.1128/ cmr.00051-08 Coates, D. E., Kardos, T. B., Moffat, S. M., & Kardos, R. L. (2009). Dental therapists and dental hygienists educated for the New Zealand environment. Journal of Dental Education, 73(8), 1001-1008. Crocombe, L. A., Broadbent, J. M., Thomson, W. M., Brennan, D. S., Slade, G. D., & Poulton, R. (2010). Dental visiting trajectory patterns and their antecedents. Journal of Public Health Dentistry, Advance Online Publication. doi: 10.1111/j.1752-7325.2010.00196.x Cullinan, M. P., Ford, P. J., & Seymour, G. J. (2009). Periodontal disease and systemic health: Current status. Australian Dental Journal, 54(Suppl. 1), S62-S69. doi: 10.1111/j.1834-7819.2009.01144.x Daroux, F. Y., Carr, D. J., Kieser, J., Niven, B. E., & Taylor, M. C. (2010). Effect of laundering on blunt force impact damage in fabrics. Forensic Science International, 197, 21-29. doi: 10.1016/j.forsciint.2009.12.016 Dennison, J., Batra, A., & Herbison, P. (2009). The maxillary artery and the lateral pterygoid muscle: The New Zealand story. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 108(5), e26-e29. doi: 10.1016/j. tripleo.2009.07.029 Dickson, G. C., Poulter, R., Maas, E. W., Probert, P. K., & Kieser, J. A. (2010). Marine bacterial succession as a potential indicator of postmortem submersion interval. Forensic Science International, Advance Online Publication. doi: 10.1016/j. forsciint.2010.10.016 Fairhall, T. J., Thomson, M. W., Kieser, J. A., Broughton, J. R., Cullinan, M. P., & Seymour, G. J. (2009). Home or away? Differences between home- and clinic-based dental examinations for older people. Gerodontology, 26(3), 179-186. doi: 10.1111/j.1741-2358.2008.00263.x Farah, R. A., Monk, B. C., Swain, M. V., & Drummond, B. K. (2010). Protein content of molar-incisor hypomineralisation enamel. Journal of Dentistry, 38, 591-596. doi: 10.1016/j.jdent.2010.04.012 Farah, R. A., Swain, M. V., Drummond, B. K., Cook, R., & Atieh, M. (2010). Mineral density of hypomineralised enamel. Journal of Dentistry, 38(1), 50-58. doi: 10.1016/j.jdent.2009.09.002 Farah, R., Drummond, B. K., Swain, M., & Williams, S. (2010). Linking the clinical presentation of molar-incisor hypomineralisation to its mineral density. International Journal of Paediatric Dentistry, 20(5), 353-360. doi: 10.1111/j.1365- 263X.2010.01061.x Farella, M., Palla, S., & Gallo, L. M. (2009). Time-frequency analysis of rhythmic masticatory muscle activity. Muscle & Nerve, 39, 828-836. doi: 10.1002/mus.21262 Farella, M., Palumbo, A., Milani, S., Avecone, S., Gallo, L. M., & Michelotti, A. (2009). Synergist coactivation and substitution pattern of the human masseter and temporalis muscles during sustained static contractions. Clinical Neurophysiology, 120(1), 190-197. doi: 10.1016/j.clinph.2008.10.004 Farella, M., Soneda, K., Vilmann, A., Thomsen, C. E., & Bakke, M. (2010). Jaw muscle soreness after tooth-clenching depends on force level. Journal of Dental Research, 89(7), 717-721. doi: 10.1177/0022034510365448 Field, C., Ichim, I., Swain, M. V., Chan, E., Darendeliler, M. A., Li, W., & Li, Q. (2009). Mechanical responses to orthodontic loading: A 3-dimensional finite element multi-tooth model. American Journal of Orthodontics and Dentofacial Orthopedics, 135(2), 174-181. doi: 10.1016/j.ajodo.2007.03.032 Filoche, S. K., Cornford, E., Gaude, W., Wong, M., Heasman, P., & Thomson, W. M. (2010). Smoking, chronic periodontitis and smoking cessation support: Reviewing the role of dental professionals. New Zealand Dental Journal, 106(2), 74-77. Ford, P. J., Raphael, S. L., Cullinan, M. P., Jenkins, A. J., West, M. J., & Seymour, G. J. (2010). Why should a doctor be interested in oral disease? Expert Review of Cardiovascular Therapy, 8(10), 1483-1493. doi: 10.1586/erc.10.109 Friedlander, L. T., Cullinan, M. P., & Love, R. M. (2009). Dental stem cells and their potential role in apexogenesis and apexification. International Endodontic Journal, 42(11), 955-962. doi: 10.1111/j.1365-2591.2009.01622.x Gale, C., Hannah, A., Swain, N., Gray, A., Coverdale, J., & Oud, N. (2009). Patient aggression perceived by community support workers. Australasian Psychiatry, 17(6), 497-501. doi: 10.1080/10398560903287516 Gowda, S., Thomson, W. M., Foster Page, L. A., & Croucher, N. A. (2009). What difference does using bitewing radiographs make to epidemiological estimates of dental caries prevalence and severity in a young adolescent population with high caries experience? Caries Research, 43(6), 436-441. doi: 10.1159/000252977 Gregory, J., Thomson, W. M., Broughton, J. R., Cullinan, M. P., Seymour, G. J., Kieser, J. A., Donaghy, M-A., & Shearer, D. M. (2010). Experiences and perceptions of oral health and oral health care among a sample of older New Zealanders. Gerodontology, Advance Online Publication. doi: 10.1111/j.1741-2358.2010.00402.x

Division of HEALTH SCIENCES 113 Hannah, A., Lim, B. T., & Ayers, K. M. (2009). Emotional intelligence and clinical interview performance of dental students. Journal of Dental Education, 73(9), 1107-1117. Hashim, R., Williams, S. M., & Thomson, W. M. (2009). Diet and caries experience among preschool children in Ajman, United Arab Emirates. European Journal of Oral Sciences, 117(6), 734-740. doi: 10.1111/j.1600-0722.2009.00688.x Hashim, R., Williams, S. M., Thomson, W. M., & Awad, M. A. (2010). Caries prevalence and intra-oral pattern among young children in Ajman. Community Dental Health, 27(2), 109-113. doi: 10.1922/CDH_2428Hashim05 Ivnitski-Steele, I., Holmes, A. R., Lamping, E., Monk, B. C., Cannon, R. D., & Sklar, L. A. (2009). Identification of Nile red as a fluorescent substrate of the Candida albicans ATP-binding cassette transporters Cdr1p and Cdr2p and the major facilitator superfamily transporter Mdr1p. Analytical Biochemistry, 394(1), 87-91. doi: 10.1016/j.ab.2009.07.001 Kardos, R. L., Cook, J. M., Butson, R. J., & Kardos, T. B. (2009). The development of an ePortfolio for life-long reflective learning and auditable professional certification. European Journal of Dental Education, 13(3), 135-141. doi: 10.1111/j.1600-0579.2008.00551.x Kemp, S. E., Carr, D. J., Kieser, J., Niven, B. E., & Taylor, M. C. (2009). Forensic evidence in apparel fabrics due to stab events. Forensic Science International, 191(1-3), 86-96. doi: 10.1016/j.forsciint.2009.06.013 Kennedy, D., Kieser, J., Bolter, C., Swain, M., Singh, B., & Waddell, J. N. (2010). Tongue pressure patterns during water swallowing. Dysphagia, 25, 11-19. doi: 10.1007/s00455-009-9223-2 Lamping, E., Baret, P. V., Holmes, A. R., Monk, B. C., Goffeau, A., & Cannon, R. D. (2010). Fungal PDR transporters: Phylogeny, topology, motifs and function. Fungal Genetics and Biology, 47(2), 127-142. doi: 10.1016/j.fgb.2009.10.007 Lamping, E., Ranchod, A., Nakamura, K., Tyndall, J. D. A., Niimi, K., Holmes, A. R., Niimi, M., & Cannon, R. D. (2009). Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. Antimicrobial Agents and Chemotherapy, 53(2), 354-369. doi: 10.1128/AAC.01095-08 Ma, S., Tawse-Smith, A., Thomson, W. M., & Payne, A. G. T. (2010). Marginal bone loss with mandibular two-implant overdentures using different loading protocols and attachment systems: 10-year outcomes. International Journal of Prosthodontics, 23(4), 321-332. Milne, T. J., Ichim, I., Patel, B., McNaughton, A., & Meikle, M. C. (2009). Induction of osteopenia during experimental tooth movement in the rat: Alveolar bone remodelling and the mechanostat theory. European Journal of Orthodontics, 31(3), 221-231. doi: 10.1093/ejo/cjp032 Moffat, S. M., Coates, D. E., & Meldrum, A. M. (2009). New Zealand’s changing oral health workforce. A dental practioner’s guide to dual-trained dental therapists/dental hygienists. New Zealand Dental Journal, 105(2), 57-61. Mohamed, A. R., Thomson, W. M., & Mackay, T. D. (2010). An epidemiological comparison of Dean’s index and the Developmental Defects of Enamel (DDE) index. Journal of Public Health Dentistry, 70(4), 344-347. doi: 10.1111/j.1752- 7325.2010.00186.x Ng, L. K., Rich, A. M., Hussaini, H. M., Thomson, W. M., Fisher, A., Horne, L., & Seymour, G. J. (2010). Toll-like receptor 2 is present in the microenvironment of oral squamous cell carcinoma. British Journal of Cancer, Advance Online Publication. doi: 10.1038/sj.bjc.6606057 Niimi, K., Monk, B. C., Hirai, A., Hatakenaka, K., Umeyama, T., Lamping, E., ..., Cannon, R. D., & Niimi, M. (2010). Clinically significant micafungin resistance in Candida albicans involves modification of a glucan synthase catalytic subunit GSC1 (FKS1) allele followed by loss of heterozygosity. Journal of Antimicrobial Chemotherapy, 65, 842-852. doi: 10.1093/jac/ dkq073 Niimi, K., & Niimi, M. (2009). The mechanisms of resistance to echinocandin class of antifungal drugs [Article in Japanese]. Nippon Ishinkin Gakkai Zasshi [Japanese Journal of Medical Mycology], 50(2), 57-66. Niimi, M. (2010). Characterization of the multi-drug efflux systems of pathogenic fungi using functional hyperexpression in Saccharomyces cerevisiae. Nippon Ishinkin Gakkai Zasshi, 51(2), 79-86. Niimi, M., Firth, N. A., & Cannon, R. D. (2010). Antifungal drug resistance of oral fungi. Odontology, 98(1), 15-25. doi: 10.1007/s10266-009-0118-3 Ohlrich, E. J., Cullinan, M. P., & Seymour, G. J. (2009). The immunopathogenesis of periodontal disease. Australian Dental Journal, 54(Suppl. 1), S2-S10. doi: 10.1111/j.1834-7819.2009.01139.x Paduano, S., Iodice, G., Farella, M., Silva, R., & Michelotti, A. (2009). Orthodontic treatment and management of limited mouth opening and oral lesions in a patient with congenital insensitivity to pain: Case report. Journal of Oral Rehabilitation, 36(1), 71-78. doi: 10.1111/j.1365-2842.2008.01887.x Park, C., Swain, M., & Duncan, W. (2010). Micro-computerised tomography optimisation for the measurement of bone mineral density around titanium dental implants. Journal of Biomechanical Science and Engineering, 5(1), 2-10. doi: 10.1299/jbse.5.2 Parker, E. J., Jamieson, L. M., Broughton, J., Albino, J., Lawrence, H. P., & Roberts-Thomson, K. (2010). The oral health of indigenous children: A review of four nations. Journal of Paediatrics and Child Health, 46(9), 483-486. doi: 10.1111/j.1440- 1754.2010.01847.x Pearce, M. S., Thomson, W. M., Walls, A. W. G., & Steele, J. G. (2009). Lifecourse socio-economic mobility and oral health in middle age. Journal of Dental Research, 88(10), 938-941. doi: 10.1177/0022034509344524 Petracci, E., Farella, M., Galeone, C., Albano, A., Ferraroni, M., & Decarli, A. (2009). Survival analysis with clustered observations of orthodontic brackets. Statistics in Medicine, 28(28), 3483-3491. doi: 10.1002/sim.3641 Power, D. A., Cordiner, S. J., Kieser, J. A., Tompkins, G. R., & Horswell, J. (2010). PCR-based detection of salivary bacteria as a marker of expirated blood. Science and Justice, 50(2), 59-63. doi: 10.1016/j.scijus.2009.04.006

114 RESEARCH REPORT 2009/2010 Rodrigues, E., Chong, K., Holmes, A. R., Cannon, R. D., Ruske, D. R., & Dawes, P. J. D. (2009). An in-vitro device for the assessment of biofilm mediated voice prosthesis damage: How we do it. Clinical Otolaryngology, 34(5), 481-484. doi: 10.1111/j.1749-4486.2009.01996.x Rose, D., Quick, A., Swain, M., & Herbison, P. (2009). Moment-to-force characteristics of preactivated nickel-titanium and titanium-molybdenum alloy symmetrical T-loops. American Journal of Orthodontics and Dentofacial Orthopedics, 135(6), 757-763. doi: 10.1016/j.ajodo.2007.06.015 Schätzle, M., Faddy, M. J., Cullinan, M. P., Seymour, G. J., Lang, N. P., Bürgin, W., Ånerud, Å., Boysen, H., & Löe, H. (2009). The clinical course of chronic periodontitis: V. Predictive factors in periodontal disease. Journal of Clinical Periodontology, 36(5), 365-371. doi: 10.1111/j.1600-051X.2009.01391.x Schwass, D. R., Swain, M. V., Purton, D. G., & Leichter, J. W. (2009). A system of calibrating microtomography for use in Caries Research. Caries Research, 43(4), 314-321. doi: 10.1159/000226230 Shearer, D. (2010). Most cited: Number 9. The prevalence of dental caries in 12- and 13-year old new zealand children in 1977 and 1982. New Zealand Dental Journal, 106(2), 78-80. Shearer, D. M., & Thomson, W. M. (2010). Intergenerational continuity in oral health: A review. Community Dentistry and Oral Epidemiology, 38, 479-486. doi: 10.1111/j.1600-0528.2010.00560.x Smith, M., Seymour, G. J., & Cullinan, M. P. (2010). Histopathological features of chronic and aggressive periodontitis. Periodontology 2000, 53(1), 45-54. doi: 10.1111/j.1600-0757.2010.00354.x Sussex, P. V., Thomson, W. M., & Fitzgerald, R. P. (2010). Understanding the ‘epidemic’ of complete tooth loss among older New Zealanders. Gerodontology, 27(2), 85-95. doi: 10.1111/j.1741-2358.2009.00306.x Swe, P. M., Heng, N. C. K., Cook, G. M., Tagg, J. R., & Jack, R. W. (2010). Identification of Dysl, the immunity factor of the streptococcal bacteriocin dysgalacticin. Applied and Environmental Microbiology, 76(23), 7885-7889. doi: 10.1128/ AEM.01707-10 Thomson, W. M., Broadbent, J. M., Locker, D., & Poulton, R. (2009). Trajectories of dental anxiety in a birth cohort. Community Dentistry and Oral Epidemiology, 37(3), 209-219. doi: 10.1111/j.1600-0528.2009.00473.x Thomson, W. M., Williams, S. M., Broadbent, J. M., Poulton, R., & Locker, D. (2010). Long-term dental visiting patterns and adult oral health. Journal of Dental Research, 89(3), 307-311. doi: 10.1177/0022034509356779 Tong, D. C., Kumar, R. R., Kok, S., De Silva, R. K., & Thomson, W. M. (2010). Patterns of maxillofacial fracture presentation in Dunedin from 2000 to 2005. New Zealand Dental Journal, 106(1), 16-19. Tordoff, J., Simonsen, K., Thomson, W. M., & Norris, P. T. (2010). ²It’s just routine.²: A qualitative study of medicine-taking amongst older people in New Zealand. Pharmacy World & Science, 32, 154-161. doi: 10.1007/s11096-009-9361-5 Traebert, J., de Lacerda, J. T., Thomson, W. M., Foster Page, L., & Locker, D. (2010). Differential item functioning in a

Brazilian-Portuguese version of the Child Perceptions Questionnaire (CPQ11-14). Community Dentistry and Oral Epidemiology, 38(2), 129-135. doi: 10.1111/j.1600-0528.2009.00525.x Traebert, J., Foster Page, L. A., Thomson, W. M., & Locker, D. (2010). Differential item functioning related to ethnicity in an oral health-related quality of life measure. International Journal of Paediatric Dentistry, 20(6), 435-441. doi: 10.1111/j.1365-263X.2010.01066.x Visscher, C. M., Naeije, M., De Laat, A., ..., Farella, M., & Lobbezoo, F. (2009). Diagnostic accuracy of temporomandibular disorder pain tests: A multicenter study. Journal of Orofacial Pain, 23(2), 108-114. Waddell, J. N., Payne, A. G. T., & Kieser, J. A. (2010). Scanning electron microscopy observations of failures of implant overdenture bars: A case series report. Clinical Implant Dentistry and Related Research, 12(1), 26-38. doi: 10.1111/j.1708- 8208.2008.00127.x Welch, C. L., Thomson, W. M., & Kennedy, R. (2010). ACC claims for sports-related dental trauma from 1999 to 2008: A retrospective analysis. New Zealand Dental Journal, 106(4), 137-142. Wescombe, P. A., Heng, N. C. K., Burton, J. P., Chilcott, C. N., & Tagg, J. R. (2009). Streptococcal bacteriocins and the case for Streptococcus salivarius as model oral probiotics. Future Microbiology, 4(7), 819-835. doi: 10.2217/fmb.09.61 Wescombe, P. A., Heng, N. C. K., Burton, J. P., & Tagg, J. R. (2010). Something old and something Probiotics and Antimicrobial Proteins, 2(1), 37-45. doi: 10.1007/s12602-009-9026-7 Willis, D. H. R., Tong, D. C., Thomson, W. M., & Love, R. M. (2010). Maxillofacial trauma and the GDP: Speciality recognition and patterns of referral. New Zealand Dental Journal, 106(3), 97-102. Zhang, N., Cannon, R. D., Holland, B. R., Patchett, M. L., & Schmid, J. (2010). Impact of genetic background on allele selection in a highly mutable Candida albicans gene, PNG2. PLoS ONE, 5(3), e9614. doi: 10.1371/journal.pone.0009614 Zhang, N., Upritchard, J. E., Holland, B. R., Fenton, L. E., Ferguson, M. M., Cannon, R. D., & Schmid, J. (2009). Distribution of mutations distinguishing the most prevalent disease-causing Candida albicans genotype from other genotypes. Infection, Genetics & Evolution, 9(4), 493-500. doi: 10.1016/j.meegid.2009.01.007 Zhou, J., Paul, A., Bennani, V., Thomson, W. M., & Firth, N. (2010). New Zealand dental practitioners’ experience of patient allergies to dental alloys used for prosthodontics. New Zealand Dental Journal, 106(2), 55-60.

Journal - Research Other Bennani, V., Schwass, D., & Chandler, N. (2009). Gingival retraction: Author’s response [Letter]. Journal of the American Dental Association, 140(2), 143-144. Coop, C., Fitzgerald, A., Whyman, R. A., Lethaby, A., Beatson, E., Caddie, C., Drummond, B. K., ..., & Thomson, W. M. (2009). Summary of guidance for the use of fluorides. New Zealand Dental Journal, 105(4), 135-137.

Division of HEALTH SCIENCES 115 Cullinan, M. P. (2010). Commentary on Cochrane Review: Treatment of periodontal disease for glycaemic control in people with diabetes. Australian Dental Journal, 55, 473-474. Kardos, T. (2009). Most cited: Number 7: Effect of fluoride and of soil trace elements on the morphology of the permanent molars in man [Comment]. New Zealand Dental Journal, 105(4), 138-139. O’Shea, C., Quick, A., Johnson, G., Carman, A., & Herbison, P. (2010). The effect of a Clark twin block on mandibular motion: A case report. Australian Orthodontic Journal, 26(2), 189-194. Rodrigues, E., Chong, K., Holmes, A. R., Cannon, R. D., Ruske, D. R., & Dawes, P. J. D. (2009). An in-vitro device for the assessment of biofilm mediated voice prosthesis damage: How we do it [Letter to the editor]. Clinical Otolaryngology, 34(5), 481-484. doi: 10.1111/j.1749-4486.2009.01996.x Seymour, G. J., Ford, P. J., Cullinan, M. P., Leishman, S., West, M. J., & Yamazaki, K. (2009). Infection or inflammation: The link between periodontal and cardiovascular diseases [Editorial]. Future Cardiology, 5(1), 5-9. doi: 10.2217/14796678.5.1.5

Working Paper; Discussion Paper; Technical Report Cryer, C., Lovelock, K., Lilley, R., Davidson, P., Davie, G., Samaranayaka, A., McBride, D., Milosavljevic, S., & Morgaine, K. (2009). Effective occupational health interventions in agriculture: Report of a survey of risk factors and exposures on farms [IPRU Report No. ORO76]. Dunedin, New Zealand: Injury Prevention Research Unit, Department of Preventive and Social Medicine, University of Otago. (pp. 1-169). Lilley, R., Cryer, C., Lovelock, K., Davidson, P., McBride, D., Milosavljevic, S., & Morgaine, K. (2009). Effective occupational health interventions in agriculture: An international literature review of primary interventions designed to reduce injury and disease in agriculture [IPRU Report No. ORO75]. Dunedin, New Zealand: Injury Prevention Research Unit, Department of Preventive and Social Medicine, University of Otago. (pp. 1-68).

Journal Editor Armitage, G. C., Cullinan, M. P., & Seymour, G. J. (Eds.). (2010). Periodontology 2000, 53.

Otago School of Medical Sciences Department of Anatomy

Authored Book - Research Jones, D. G., & Whitaker, M. I. (2009). Speaking for the dead: The human body in biology and medicine (2nd ed.). Farnham, UK: Ashgate, 296p.

Authored Book - Other Stringer, M. D. (2009). Eponyms in surgery and anatomy of the liver, bile ducts and pancreas. London: Royal Society of Medicine Press, 208p.

Edited Book - Research Elford, R. J., & Jones, D. G. (Eds.). (2009). A tangled web: Medicine and theology in dialogue (Vol. 1). Oxford, UK: Peter Lang, 288p. Jones, D. G., & Elford, R. J. (Eds.). (2010). A glass darkly: Medicine and theology in further dialogue. Bern, Switzerland: Peter Lang, 246p.

Chapter in Book - Research Aziz, A., Parmar, D., McNaughton, A., & Tompkins, G. R. (2010). Bacterial viability determination in a dentinal tubule infection model by confocal laser scanning microscopy. In G. J. Seymour, M. P. Cullinan & N. C. K. Heng (Eds.), Oral Biology (pp. 141-150). New York: Springer. doi: 10.1007/978-1-60761-820-1_10 Godbole, P. P., & Stringer, M. D. (2010). Patent processus vaginalis. In J. P. Gearhart, R. C. Rink, & P. D. E. Mouriquand (Eds.), Pediatric urology (2nd ed.). (pp. 577-584). PA: Saunders. Grattan, D. R., & Bridges, R. S. (2009). Prolactin actions in the brain. In D. W. Pfaff, A. P. Arnold, A. M. Etgen, S. E. Fahrbach,& R. T. Rubin (Eds.), Hormones, brain and behavior (Vol. 4) (2nd ed.). (pp. 2471-2503). San Diego, CA: Academic Press. Heng, N. C. K., & Stanton, J-A. L. (2010). Oral bacterial genome sequencing using the high-throughput Roche Genome Sequencer FLX System. In G. J. Seymour, M. P. Cullinan & N. C. K. Heng (Eds.), Oral Biology (pp. 197-218). New York: Springer. doi: 10.1007/978-1-60761-820-1_14 Jones, D. G. (2009). Enhancement: Is baseless speculation misleading theologians and bioethicists? In R. J. Elford & D. G. Jones (Eds.), A tangled web: Medicine and theology in dialogue (pp. 123-142). Oxford, UK: Peter Lang. Jones, D. G. (2009). Introduction. In R. J. Elford & D. G. Jones (Eds.), A tangled web: Medicine and theology in dialogue (pp. 9-16). Oxford, UK: Peter Lang. Jones, D. G. (2009). Is PGD a form of eugenics? In R. J. Elford & D. G. Jones (Eds.), A tangled web: Medicine and theology in dialogue (pp. 143-161). Oxford, UK: Peter Lang. Jones, D. G. (2009). Regulatory procedures. In R. J. Elford & D. G. Jones (Eds.), A tangled web: Medicine and theology in dialogue (pp. 201-219). Oxford, UK: Peter Lang.

116 RESEARCH REPORT 2009/2010 Jones, D. G. (2009). The human body: An anatomist’s journey from death to life. In R. J. Elford & D. G. Jones (Eds.), A tangled web: Medicine and theology in dialogue (pp. 105-121). Oxford, UK: Peter Lang. Jones, D. G. (2010). Conclusion: The necessity of dialogue. In D. G. Jones & R. J. Elford (Eds.), A glass darkly: Medicine and theology in further dialogue (pp. 211-238). Bern, Switzerland: Peter Lang. Jones, D. G. (2010). The biomedical technologies: Prospects and challenges. In D. G. Jones & R. J. Elford (Eds.), A glass darkly: Medicine and theology in further dialogue (pp. 9-32). Bern, Switzerland: Peter Lang. Jones, D. G., & Whitaker, M. I. (2009). In vitro fertilization and the embryonic revolution. In R. Luppicini & R. Adell (Eds.), Handbook of research on technoethics (Vol. II) (pp. 609-622). Hersey, PA: Information Science Reference. Jones, D. G., & Whitaker, M. I. (2009). Scientific fraud: The demise of idealistic science. In R. J. Elford & D. G. Jones (Eds.), A tangled web: Medicine and theology in dialogue (pp. 89-104). Oxford, UK: Peter Lang. Larsen, C. M., & Grattan, D. R. (2010). Exposure to female pheromones during pregnancy causes postpartum anxiety in mice. In G. Litwack (Ed.), Pheromones: Vitamins & Hormones (Vol. 83) (pp. 137-149). Amsterdam: Academic Press. doi: 10.1016/ S0083-6729(10)83005-5 Leitch, B., & Pitman, R. M. (2009). Neuromodulation of mechanosensory input to the insect CNS. In A. Kamkin & I. Kiseleva (Eds.), Mechanosensitivity of the nervous system (Vol. 2) (pp. 145-170). Amsterdam: Springer. Matisoo-Smith, E. (2009). Pigs and Goats. In R. G. Gillespie & D. A. Clague (Eds.), Encyclopedia of Islands (pp. 741-743). Berkeley, CA: University of California Press. Oorschot, D. E. (2010). Cell types in the different nuclei of the basal ganglia. In H. Steiner & K. Y. Tseng (Eds.), Handbook of basal ganglia structure and function (pp. 63-74). London: Academic Press. Overton, P. G., & Clements, K. M. (2010). Does collicular hyper-responsivity underlie increased distractibility in attention deficit hyperactivity disorder? In A. M. Columbus (Ed.), Advances in psychology research (Vol. 67) . Nova Science. Plenz, D., & Wickens, J. R. (2010). The striatal skeleton: Medium spiny projection neurons and their lateral connections. In H. Steiner & K. Y. Tseng (Eds.), Handbook of basal ganglia structure and function (pp. 99-112). London: Academic Press. Redgrave, P., Coizet, V., & Reynolds, J. (2010). Phasic dopamine signaling and basal ganglia function. In H. Steiner & K. Y. Tseng (Eds.), Handbook of basal ganglia structure and function (pp. 549-559). London: Academic Press. Stringer, M. D. (2009). Liver abscess in children. In D. K. Gupta, S. Sharma, & R. G. Azizkhan (Eds.), Pediatric surgery: Diagnosis and management (Vol. 2) (pp. 925-935). New Delhi, India: Jaypee Brothers Medical Publishers. Stringer, M. D. (2009). Liver resections and allograft preparation. In D. K. Gupta, S. Sharma, & R. G. Azizkhan (Eds.), Pediatric surgery: Diagnosis and management (Vol. 2) (pp. 949-968). New Delhi, India: Jaypee Brothers Medical Publishers. Wickens, J. R., & Arbuthnott, G. W. (2010). Gating of cortical input to the striatum. In H. Steiner & K. Y. Tseng (Eds.), Handbook of basal ganglia structure and function (pp. 341-351). London: Academic Press.

Chapter in Book - Other Jones, G. (2009). Borderlands. In R. J. Berry (Ed.), Real scientists: Real faith (pp. 58-71). Oxford, UK: Monarch Books. Nicholson, H., & Assinder, S. (2009). Male gametogenesis. In S. Fleming & S. Cooke (Eds.), Textbook of assisted reproduction for scientists in reproductive technology (pp. 3-29). Freemantle, Australia: Vivid Publishing. Stringer, M. D. (2009). Intestinal malrotation. In P. Puri & M. Höllwarth (Eds.), Pediatric surgery: Diagnosis and management (pp. 393-403). Berlin, Germany: Springer-Verlag. Stringer, M. D. (2009). Portal hypertension. In P. Puri & M. Höllwarth (Eds.), Pediatric surgery: Diagnosis and management (pp. 561-570). Berlin, Germany: Springer-Verlag.

Journal - Research Article Abdelkrim, J., Byrom, A. E., & Gemmell, N. J. (2010). Fine-scale genetic structure of mainland invasive Rattus rattus populations: Implications for restoration of forested conservation areas in New Zealand. Conservation Genetics, 11(5), 1953-1964. doi: 10.1007/s10592-010-0085-9 Abdelkrim, J., Pascal, M., & Samadi, S. (2009). Genetic structure and functioning of alien ship rat populations from a Corsican micro-insular complex. Biological Invasions, 11, 473-482. doi: 10.1007/s10530-008-9263-9 Abdelkrim, J., Robertson, B. C., Stanton, J-A. L., & Gemmell, N. J. (2009). Fast, cost-effective development of species-specific microsatellite markers by genomic sequencing. BioTechniques, 46(3), 185-192. doi: 10.2144/000113084 Addison, D. J., & Matisoo-Smith, E. (2010). Rethinking Polynesians origins: A West-Polynesia Triple-I model. Archaeology In Oceania, 45(1), 1-12. Ahmadi, O., de L Nicholson, M., Gould, M. L., Mitchell, A., & Stringer, M. D. (2010). Interstitial cells of Cajal are present in human extrahepatic bile ducts. Journal of Gastroenterology and Hepatology, 25(2), 277-285. doi: 10.1111/j.1440- 1746.2009.05980.x Alizai, N. K., Richards, E. M., & Stringer, M. D. (2010). Is cholecystectomy really an indication for concomitant splenectomy in mild hereditary spherocytosis? Archives of Disease in Childhood, 95(8), 596-599. doi: 10.1136/adc.2009.178228 Anderson, G. M., Relf, H-L., Rizwan, M. Z., & Evans, J. J. (2009). Central and peripheral effects of RFamide-related peptide-3 on luteinizing hormone and prolactin secretion in rats. Endocrinology, 150(4), 1834-1840. doi: 10.1210/en.2008-1359 Asano, Y., Koishi, K., Frugier, T., & McLennan, I. S. (2009). Mice with disrupted TGFb signaling have normal cerebella development, but exhibit facial dysmorphogenesis and strain-dependent deficits in their body wall. Cellular and Molecular Neurobiology, 29(5), 621-633. doi: 10.1007/s10571-009-9354-x Assinder, S. J., Stanton, J-A. L., & Prasad, P. D. (2009). Transgelin: An actin-binding protein and tumour suppressor. International Journal of Biochemistry and Cell Biology, 41(3), 482-486. doi: 10.1016/j.biocel.2008.02.011

Division of HEALTH SCIENCES 117 Becker, I., Baxter, G. D., & Woodley, S. J. (2010). The vastus lateralis muscle: An anatomical investigation. Clinical Anatomy, 23, 575-585. doi: 10.1002/ca.20974 Becker, I., Woodley, S. J., & Baxter, G. D. (2009). Gross morphology of the vastus lateralis muscle: An anatomical review. Clinical Anatomy, 22(4), 436-450. doi: 10.1002/ca.20792 Becker, I., Woodley, S. J., & Stringer, M. D. (2010). The adult human pubic symphysis: A systematic review. Journal of Anatomy, 217, 475-487. doi: 10.1111/j.1469-7580.2010.01300.x Bentley, R. A., Cox, K., Tayles, N., Higham, C., Macpherson, C., Nowell, G., Cooper, M., & Hayes, T. E. F. (2009). Community diversity at Ban Lum Khao, Thailand: Isotopic evidence from the skeletons. Asian Perspectives, 48(1), 79-97.

Bergin, D. H., & Liu, P. (2010). Agmatine protects against b-amyloid25-35-induced memory impairments in the rat. Neuroscience, 169, 794-811. doi: 10.1016/j.neuroscience.2010.05.004 Bishop, J. R., Burniston, M. T., Barnfield, M. C., Stringer, M. D., Prasad, R., Davison, S. M., Rajwal, S., & McClean, P. (2009). Renal function evaluated by measured GFR during follow-up in pediatric liver transplant recipients. Pediatric Transplantation, 13(1), 96-103. doi: 10.1111/j.1399-3046.2008.00999.x Brown, R. S. E., Kokay, I. C., Herbison, A. E., & Grattan, D. R. (2010). Distribution of prolactin-responsive neurons in the mouse forebrain. Journal of Comparative Neurology, 518(1), 92-102. doi: 10.1002/cne.22208 Buckley, H. R., Tayles, N., Halcrow, S. E., Robb, K., & Fyfe, R. (2010). The people of Wairau Bar: A re-examination. Journal of Pacific Archaeology, 1(2), 1-20. Buschiazzo, E., & Gemmell, N. J. (2009). Evolutionary and phylogenetic significance of platypus microsatellites conserved in mammalian and other vertebrate genomes. Australian Journal of Zoology, 57(3-4), 175-184. doi: 10.1071/zo09038 Carr, D. J., Cruthers, N. M., Girvan, E., & Gould, K. S. (2009). Variation in epicuticular wax morphology on Phormium tenax leaves as a possible indicator of cultivar identification. New Zealand Journal of Botany, 47(2), 149-153. Caudron, A. K., Negro, S. S., Fowler, M., Boren, L., Poncin, P., Robertson, B. C., & Gemmell, N. J. (2009). Alternative mating tactics in the New Zealand fur seal (Arctocephalus forsteri): When non-territorial males are successful too. Australian Journal of Zoology, 57(6), 409-421. doi: 10.1071/ZO09024 Chung, T-Y., Peplow, P. V., & Baxter, G. D. (2010). Laser photobiomodulation of wound healing in diabetic and non- diabetic mice: Effects in splinted and unsplinted wounds. Photomedicine and Laser Surgery, 28(2), 251-261. doi: 10.1089/ pho.2009.2493 Chung, T-Y., Peplow, P. V., & Baxter, G. D. (2010). Laser photobiostimulation of wound healing: Defining a dose response for splinted wounds in diabetic mice. Lasers in Surgery and Medicine, 42(9), 656-664. doi: 10.1002/lsm.20981 Chung, T-Y., Peplow, P. V., & Baxter, G. D. (2010). Testing photobiomodulatory effects of laser irradiation on wound healing: Development of an improved model for dressing wounds in mice. Photomedicine and Laser Surgery, 28(5), 589-596. doi: 10.1089/pho.2009.2641 Claasen, A. M., Guévremont, D., Mason-Parker, S. E., Bourne, K., Tate, W. P., Abraham, W. C., & Williams, J. M. (2009). Secreted amyloid precursor protein-a upregulates synaptic protein synthesis by a protein kinase G-dependent mechanism. Neuroscience Letters, 460, 92-96. doi: 10.1016/j.neulet.2009.05.040 Clay, C., Gleeson, D., Howitt, R., Lawrence, H., Abdelkrim, J., & Gemmell, N. (2010). Characterisation of microsatellite markers for the primitive New Zealand frog, Leiopelma hochstetteri. Conservation Genetics Resources, 2(1), 301-303. doi: 10.1007/s12686-010-9211-8 Clements, K. M., & Wainwright, P. E. (2010). Swim stress increases hippocampal Zif268 expression in the spontaneously hypertensive rat. Brain Research Bulletin, 82, 259-263. doi: 10.1016/j.brainresbull.2010.05.002 Conley, D., Hurst, P. R., & Stringer, M. D. (2010). An investigation of human jejunal and ileal arteries. Anatatomical Science International, 85(1), 23-30. doi: 10.1007/s12565-009-0047-9 Connelly, W. M., Schulz, J. M., Lees, G., & Reynolds, J. N. J. (2010). Differential short-term plasticity at convergent inhibitory synapses to the substantia nigra pars reticulata. Journal of Neuroscience, 30(44), 14854-14861. doi: 10.1523/ JNEUROSCI.3895-10.2010 Constantin, S., Jasoni, C. L., Wadas, B., & Herbison, A. E. (2010). g-aminobutyric acid and glutamate differentially regulate intracellular calcium concentrations in mouse gonadotropin-releasing hormone neurons. Endocrinology, 151(1), 262-270. doi: 10.1210/en.2009-0817 Cornwall, J., Deries, M., & Duxson, M. (2010). Morphology of the lumbar transversospinal muscles examined in a mouse bearing a muscle fiber-specific nuclear marker. Anatatomical Record, 293(12), 2107-2113. doi: 10.1002/ar.21265 Cowan, D. C., Cowan, J. O., Palmay, R., Williamson, A., & Taylor, D. R. (2010). Effects of steroid therapy on inflammatory cell subtypes in asthma. Thorax, 65(5), 384-390. doi: 10.1136/thx.2009.126722 Cowan, D. C., Cowan, J. O., Palmay, R., Williamson, A., & Taylor, D. R. (2010). Simvastatin in the treatment of asthma: Lack of steroid-sparing effect. Thorax, 65(10), 891-896. doi: 10.1136/thx.2010.138990 Cowan, D. C., Hewitt, R. S., Cowan, J. O., Palmay, R., Williamson, A., Lucas, S. J. E., Murrell, C. J., Thomas, K. N., & Taylor, D. R. (2010). Exercise-induced wheeze: Fraction of exhaled nitric oxide-directed management. Respirology, 15, 683-690. doi: 10.1111/j.1440-1843.2010.01740.x Cowin, P. A., Gold, E., Aleksova, J., O’Bryan, M. K., Foster, P. M. D., Scott, H. S., & Risbridger, G. P. (2010). Vinclozolin exposure in utero induces postpubertal prostatitis and reduces sperm production via a reversible hormone-regulated mechanism. Endocrinology, 151(2), 783-792. doi: 10.1210/en.2009-0982 Dejean, C., Hyland, B., & Arbuthnott, G. (2009). Cortical effects of subthalamic stimulation correlate with behavioral recovery from dopamine antagonist induced akinesia. Cerebral Cortex, 19(5), 1055-1063. doi: 10.1093/cercor/bhn149

118 RESEARCH REPORT 2009/2010 Dennison, J., Batra, A., & Herbison, P. (2009). The maxillary artery and the lateral pterygoid muscle: The New Zealand story. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 108(5), e26-e29. doi: 10.1016/j. tripleo.2009.07.029 Dennison, K. J. (2009). Fused atlantic posterior arch hypoplasia - Rachischisis? Journal of Forensic Odonto-Stomatology, 27, 75-80. Deries, M., Schweitzer, R., & Duxson, M. J. (2010). Developmental fate of the mammalian myotome. Developmental Dynamics, Advance Online Publication. doi: 10.1002/dvdy.22425 Dias, G. J., Mahoney, P., Swain, M., Kelly, R. J., Smith, R. A., & Ali, M. A. (2010). Keratin-hydroxyapatite composites: Biocompatibility, osseointegration, and physical properties in an ovine model. Journal of Biomedical Materials Research: Part A, Advance Online Publication. doi: 10.1002/jbm.a.32908 Dias, G. J., Peplow, P. V., McLaughlin, A., Teixeira, F., & Kelly, R. J. (2010). Biocompatibility and osseointegration of reconstituted keratin in an ovine model. Journal of Biomedical Materials Research, 92A(2), 513-520. doi: 10.1002/ jbm.a.32394 Douglas, S. A., & Bunn, S. J. (2009). Interferon-a signalling in bovine adrenal chromaffin cells: Involvement of signal- transducer and activator of transcription 1 and 2, extracellular signal-regulated protein kinases 1/2 and serine 31 phosphorylation of tyrosine hydroxylase. Journal of Neuroendocrinology, 21(3), 200-207. doi: 10.1111/j.1365- 2826.2009.01821.x Douglas, S. A., Sreenivasan, D., Carman, F. H., & Bunn, S. J. (2010). Cytokine interactions with adrenal medullary chromaffin cells. Cellular and Molecular Neurobiology, Advance Online Publication. doi: 10.1007/s10571-010-9593-x Ducret, E., Anderson, G. M., & Herbison, A. E. (2009). RFamide-related peptide-3, a mammalian gonadotropin-inhibitory hormone ortholog, regulates gonadotropin-releasing hormone neuron firing in the mouse. Endocrinology, 150(6), 2799- 2804. doi: 10.1210/en.2008-1623 Fiorini, Z., & Jasoni, C. L. (2010). A novel developmental role for Kisspeptin in the growth of GnRH neurites to the median eminence in the mouse. Journal of Neuroendocrinology, Advance Online Publication. doi: 10.1111/j.1365- 2826.2010.02059.x Fleming, J. S., McQuillan, H. J., Millier, M. J., & Sellar, G. C. (2009). Expression of ovarian tumour suppressor OPCML in the female CD-1 mouse reproductive tract. Reproduction, 137(4), 721-726. doi: 10.1530/rep-08-0511 Fong, S. W., McLennan, I. S., McIntyre, A., Reid, J., Shennan, K. I. J., & Bewick, G. S. (2010). TGF-b2 alters the characteristics of the neuromuscular junction by regulating presynaptic quantal size. PNAS, 107(30), 13515-13519. doi: 10.1073/ pnas.1001695107 Fouquet, A., Ficetola, G. F., Haigh, A., & Gemmell, N. (2010). Using ecological niche modelling to infer past, present and future environmental suitability for Leiopelma hochstetteri, an endangered New Zealand native frog. Biological Conservation, 143, 1375-1384. doi: 10.1016/j.biocon.2010.03.012 Fouquet, A., Green, D. M., Waldman, B., Bowsher, J. H., McBride, K. P., & Gemmell, N. J. (2010). Phylogeography of Leiopelma hochstetteri reveals strong genetic structure and suggests new conservation priorities. Conservation Genetics, 11(3), 907- 919. doi: 10.1007/s10592-009-9935-8 Ghosh, A., Ali, M. A., & Dias, G. J. (2009). Effect of cross-linking on microstructure and physical performance of casein protein. Biomacromolecules, 10(7), 1681-1688. doi: 10.1021/bm801341x Ghosh, A., Ali, M. A., Selvanesan, L., & Dias, G. J. (2010). Structure-function characteristics of the biomaterials based on milk- derived proteins. International Journal of Biological Macromolecules, 46, 404-411. doi: 10.1016/j.ijbiomac.2010.02.011 Giger, T., Khaitovich, P., Somel, M., Lorenc, A., Lizano, E., Harris, L. W., et al, & Ryan, M. (2010). Evolution of neuronal and endothelial transcriptomes in primates. Genome Biology and Evolution, 2(1), 284-292. doi: 10.1093/gbe/evq018 Gold, E., Jetly, N., O’Bryan, M. K., Meachem, S., Srinivasan, D., et al. (2009). Activin C antagonizes activin A in vitro and overexpression leads to pathologies in vivo. American Journal of Pathology, 174(1), 184-195. doi: 10.2353/ ajpath.2009.080296 Goldstien, S. J., Gemmell, N. J., & Schiel, D. R. (2009). Colonisation and connectivity by intertidal limpets among New Zealand, Chatham and Sub-Antarctic Islands. I. Genetic connections. Marine Ecology Progress Series, 388, 111-119. doi: 10.3354/meps08046 Goldstien, S. J., Schiel, D. R., & Gemmell, N. J. (2010). Regional connectivity and coastal expansion: Differentiating pre-border and post-border vectors for the invasive tunicate Styela clava. Molecular Ecology, 19(5), 874-885. doi: 10.1111/j.1365- 294X.2010.04527.x Gould, M. L., Williams, G., & Nicholson, H. D. (2010). Changes in caveolae, caveolin, and polymerase 1 and transcript release factor (PTRF) expression in prostate cancer progression. Prostate, Advance Online Publication. doi: 10.1002/pros.21195 Gupta, N., Zhang, H., & Liu, P. (2009). Behavioral and neurochemical effects of acute putrescine depletion by difluoromethylornithine in rats. Neuroscience, 161(3), 691-706. doi: 10.1016/j.nueroscience.2009.03.075 Halcrow, S. E., & Tayles, N. (2010). Talon cusp in a deciduous lateral incisor from prehistoric Southeast Asia. International Journal of Osteoarchaeology, 20(2), 240-247. doi: 10.1002/oa.1020 Halcrow, S. E., & Tayles, N. (2010). The archaeological infant in biological and social context: A response to Mike Lally and Traci Ardren 2008. Little artefacts: Rethinking the constitution of the archaeological infant Childhood in the Past 1, 62-77. Childhood in the Past, 3, 123-130. Hale, L., Miller, R., Barach, A., Skinner, M., & Gray, A. (2009). Motor Control Test responses to balance perturbations in adults with an intellectual disability. Journal of Intellectual & Developmental Disability, 34(1), 81-86.

Division of HEALTH SCIENCES 119 Hale, S. J. M., Mirjalili, S. A., & Stringer, M. D. (2010). Inconsistencies in surface anatomy: The need for an evidence-based reappraisal. Clinical Anatomy, Advance Online Publication. doi: 10.1002/ca.21044 Hamodeh, S., Eicke, D., Napper, R. M. A., Harvey, R. J., & Sultan, F. (2010). Population based quantification of dendrites: Evidence for the lack of microtubule-associate protein 2a,b in Purkinje cell spiny dendrites. Neuroscience, 170(4), 1004- 1014. doi: 10.1016/j.neuroscience.2010.08.021 Han, H., Deng, X., Fong, A. H., & Zhang, M. (2010). Dural entrance of the bridging vein in the middle cranial fossa: A novel classification of the cerebral veins for preoperative planning. Neurosurgery, 67(3), 9-15. doi: 10.1227/01. neu.0000381683.27324.14 Hayes, S., Valentin, F., Buckley, H., Spriggs, M., & Bedford, S. (2009). Faces of the Teouma Lapita people: Art, accuracy and facial approximation. Leonardo, 42(3), 284-285. Horn, T., Robertson, B. C., & Gemmell, N. J. (2010). The use of telomere length in ecology and evolutionary biology. Heredity, 105(6), 497-506. doi: 10.1038/hdy.2010.113 Horsburgh, K. A., & Rhines, A. (2010). Genetic characterization of an archaeological sheep assemblage from South Africa’s Western Cape. Journal Of Archaeological Science, 37(11), 2906-2910. doi: 10.1016/j.jas.2010.06.035 Howden, B. P., Seemann, T., Harrison, P. F., McEvoy, C. R., Stanton, J-A. L., Rand, C. J., Mason, C. W., et al. (2010). Complete genome sequence of Staphylococcus aureus strain JKD6008, a ST239 clone of methicillin-resistant Staphylococcus aureus with intermediate level vancomycin resistance. Journal of Bacteriology, Advance Online Publication. doi: 10.1128/JB.00951- 10 Jasoni, C. L., Porteous, R. W., & Herbison, A. E. (2009). Anatomical location of mature GnRH neurons corresponds with their birthdate in the developing mouse. Developmental Dynamics, 238(3), 524-531. Jasoni, C. L., Romanà, N., Constantin, S., Lee, K., & Herbison, A. E. (2010). Calcium dynamics in gonadotropin-releasing hormone neurons. Frontiers in Neuroendocrinology, 31, 259-269. doi: 10.1016/j.yfrne.2010.05.005 Johnson, S. L., & Brockmann, H. J. (2010). Costs of multiple mates: An experimental study in horseshoe crabs. Animal Behaviour, 80(5), 773-782. doi: 10.1016/j.anbehav.2010.07.019 Jones, D. G. (2009). Gauging public opinion towards the reproductive technologies. Kötuitui, 4, 221-224. Retrieved from http://www.royalsociety.org.nz/Site/publish/Journals/kotuitui/default.aspx Jones, D. G. (2010). Peering into people’s brains: Neuroscience’s intrusion into our inner sanctum. Perspectives on Science & Christian Faith, 62(2), 122-132. Jones, D. G., King, M. R., & Whitaker, M. I. (2009). Who gets born? How did New Zealand’s Bioethics Council arrive at its recommendations? [Viewpoint]. New Zealand Medical Journal, 122(1294). Retrieved from http://www.nzma.org.nz/ journal/122-1294/3585/ Jones, D. G., & Whitaker, M. I. (2009). Engaging with plastination and the Body Worlds phenomenon: A cultural and intellectual challenge for anatomists. Clinical Anatomy, 22(6), 770-776. doi: 10.1002/ca.20824 Jones, D. G., & Whitaker, M. I. (2009). Finding a context for discussing human life-extension. American Journal of Bioethics, 9(12), 77-79. doi: 10.1080/15265160903318376 Kennard, J. T. T., Guévremont, D., Mason-Parker, S. E., Abraham, W. C., & Williams, J. M. (2009). Increased expression, but not postsynaptic localisation, of ionotropic glutamate receptors during the late-phase of long-term potentiation in the dentate gyrus in vivo. Neuropharmacology, 56(1), 66-72. doi: 10.1016/j.neuropharm.2008.07.044 Kinaston, R. L., Buckley, H. R., Halcrow, S. E., Spriggs, M. J. T., Bedford, S., Neal, K., & Gray, A. (2009). Investigating foetal and perinatal mortality in prehistoric skeletal samples: A case study from a 3000-year-old Pacific Island cemetery site. Journal Of Archaeological Science, 36(12), 2780-2787. doi: 10.1016/j.jas.2009.09.004 Kirkland, N. T., Birbilis, N., Walker, J., Woodfield, T., Dias, G. J., & Staiger, M. P. (2010). In-vitro dissolution of magnesium- calcium binary alloys: Clarifying the unique role of calcium additions in bioresorbable magnesium implant alloys. Journal of Biomedical Materials Research B: Applied Biomaterials, 95B(1), 91-100. doi: 10.1002/jbm.b.31687 Knapp, M., Finstermeier, K., Horn, S., Stiller, M., & Hofreiter, M. (2010). Multiplex-PCR: Neue PCR-technologien für alte DNA [Multiplex-PCR: New PCR technologies for ancient DNA]. Biospektrum, 5, 531-535. Knapp, M., & Hofreiter, M. (2010). Next generation sequencing of ancient DNA: Requirements, strategies and persectives. Genes, 1(2), 227-243. doi: 10.3390/genes1020227 Knapp, M., Rohland, N., Weinstock, J., Baryshnikov, G., Sher, A., et al. (2009). First DNA sequences from Asian cave bear fossils reveal deep divergences and complex phylogeographic patterns. Molecular Ecology, 18, 1225-1238. doi: 10.1111/j.1365- 294X.2009.04088.x Knowles, P. J., Douglas, S. A., & Bunn, S. J. (2010). Nicotinic stimulation of catecholamine synthesis and tyrosine hydroxylase phosphorylation in cervine adrenal medullary chromaffin cells. Journal of Neuroendocrinology, Advance Online Publication. doi: 10.1111/j.1365-2826.2010.02100.x Koch, C., Augustine, R. A., Steger, J., ..., Anderson, G. M., Grattan, D. R., & Tups, A. (2010). Leptin rapidly improves glucose homeostasis in obese mice by increasing hypothalamic insulin sensitivity. Journal of Neuroscience, 30(48), 16180-16187. doi: 10.1523/JNEUROSCI.3202-10.2010 Ladyman, S. R., Augustine, R. A., & Grattan, D. R. (2010). Hormone interactions regulating energy balance during pregnancy. Journal of Neuroendocrinology, 22, 805-817. doi: 10.1111/j.1365-2826.2010.02017.x Ladyman, S. R., Tups, A., Augustine, R. A., Swahn-Azavedo, A., Kokay, I. C., & Grattan, D. R. (2009). Loss of hypothalamic response to leptin during pregnancy associated with development of melanocortin resistance. Journal of Neuroendocrinology, 21(5), 449-456. doi: 10.1111/j.1365-2826.2009.01862.x

120 RESEARCH REPORT 2009/2010 Ladyman, S. R., & Woodside, B. (2009). Regulation of maternal food intake and mother-pup interactions by the Y5 receptor. Physiology & Behavior, 97, 91-97. doi: 10.1016/j.physbeh.2009.02.008 Larsen, C. M., & Grattan, D. R. (2010). Prolactin-induced mitogenesis in the subventricular zone of the maternal brain during early pregnancy is essential for normal postpartum behavioral responses in the mother. Endocrinology, 151, 3805-3814. doi: 10.1210/en.2009-1385 Leitch, B., Shevtsova, O., Guévremont, D., & Williams, J. (2009). Loss of calcium channels in the cerebellum of the ataxic and epileptic stargazer mutant mouse. Brain Research, 1279, 156-167. doi: 10.1016/j.brainres.2009.04.051 Leitch, B., Shevtsova, O., & Kerr, J. R. (2009). Selective reduction in synaptic proteins involved in vesicle docking and signalling at synapses in the ataxic mutant mouse Stargazer. The Journal of Comparative Neurology, 512(1), 52-73. doi: 10.1002/ cne.21890 Leitch, B., Shevtsova, O., Reusck, K., Bergin, D. H., & Liu, P. (2010). Spatial learning-induced increase in agmatine levels at hippocampal CA1 synapses. Synapse, Advance Online Publication. doi: 10.1002/syn.20828 Leitch, B., Szostek, A., Lin, R., & Shevtsova, O. (2009). Subcellular distribution of L-type calcium channel subtypes in rat hippocampal neurons. Neuroscience, 164(2), 641-657. doi: 10.1016/j.neuroscience.2009.08.006 Leunissen, J., & Yi, H. (2009). Self-pressurized rapid freezing (SPRF): A novel cryofixation method for specimen preparation in electron microsopy. Journal of Microscopy, 235(1), 25-35. Li, C., Gao, Z., Yang, F., Martin, S. K., Haines, S. R., Deng, X., Schofield, J., & Stanton, J-A. L. (2009). Development of a nude mouse model for the study of antlerogenesis: Mechanism of tissue interactions and ossification pathway. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 312B(2), 118-135. doi: 10.1002/jez.b.21252 Liew, C. W., Sun, H., Hunter, T., & Day, C. L. (2010). RING domain dimerization is essential for RN4 function. Biochemical Journal, 431(1), 23-29. doi: 10.1042/BJ20100957 Liu, P., & Bergin, D. H. (2009). Differential effects of i.c.v. mcroinfusion of agmatine on spatial working and reference memory in the rat. Neuroscience, 159(3), 951-961. doi: 10.1016/j.neuroscience.2009.01.039 Liu, P., & Collie, N. D. (2009). Behavioral effects of agmatine in naive rats are task- and delay-dependent. Neuroscience, 163(1), 82-96. doi: 10.1016/j.neuroscience.2009.05.061 Liu, P., Jing, Y., Collie, N. D., Chary, S., & Zhang, H. (2009). Memory-related changes in l-citrulline and agmatine in the rat brain. Hippocampus, 19(7), 597-602. doi: 10.1002/hipo.20561 Liu, P., Jing, Y., & Zhang, H. (2009). Age-related changes in arginine and its metabolites in memory-associated brain structures. Neuroscience, 164(2), 611-628. doi: 10.1016/j.neuroscience.2009.08.029 Liu, P., Zhang, H., Devaraj, R., Ganesalingam, G., & Smith, P. F. (2010). A multivariate analysis of the effects of aging on glutamate, GABA and arginine metabolites in the rat vestibular nucleus. Hearing Research, 269(1-2), 122-133. doi: 10.1016/j.heares.2010.06.019 Matisoo-Smith, E. (2009). The commensal model for human settlement of the Pacific 10 years on: What can we say and where to now? Journal of Island and Coastal Archaeology, 4(2), 151-163. doi: 10.1080/15564890903155273 Matisoo-Smith, E., Hingston, M., Summerhayes, G., Robins, J., Ross, H. A., & Hendy, M. (2009). On the rat trail in Near Oceania: Applying the commensal model to the question of the Lapita colonization. Pacific Science, 63(4), 465-475. Matisoo-Smith, E., & Ramirez, J-M. (2010). Human skeletal evidence of Polynesian presence in South America? Metric analyses of six crania from Mocha Island, Chile. Journal of Pacific Archaeology, 1(2), 76-88. Matisoo-Smith, E., & Robins, J. (2009). Mitochondrial DNA evidence for the spread of Pacific rats through Oceania. Biological Invasions, 11, 1521-1527. doi: 10.1007/s10530-008-9404-1 McClea, K., & Stringer, M. D. (2010). The profile of body donors at the Otago School of Medical Sciences: Has it changed? New Zealand Medical Journal, 123(1312). Retrieved from http://www.nzma.org.nz/journal/archive.shtml McGrath, C., Nicholson, H., & Hurst, P. (2009). Le long ligament sacro-iliaque postérieur: étude histologique de ses rapports dans la région sacro-iliaque postérieure [The long posterior sacroiliac ligament: An histological study of morphological relations in the posterior sacroiliac region]. Revue du Rhumatisme, 76(1), 62-66. doi: 10.1016/j.rhum.2008.02.022 McGrath, C., Nicholson, H., & Hurst, P. (2009). The long posterior sacroiliac ligament: A histological study of morphological relations in the posterior sacroiliac region. Joint Bone Spine, 76(1), 57-62. doi: 10.1016/j.jbspin.2008.02.015 McGrath, M. C. (2010). Composite sacroiliac joint pain provocation tests: A question of clinical significance. International Journal of Osteopathic Medicine, 13(1), 24-30. doi: 10.1016/j.ijosm.2009.06.002 McGrath, M. C., & Stringer, M. D. (2010). Bony landmarks in the sacral region: The posterior superior iliac spine and the second dorsal sacral foramina: A potential guide for sonography. Surgical and Radiologic Anatomy, Advance Online Publication. doi: 10.1007/s00276-010-0735-0 Miller, R. (2009). Mechanisms of action of antipsychotic drugs of different classes, refractoriness to therapeutic effects of classical neuroleptics, and individual variation in sensitivity to their actions: PART I. Current Neuropharmacology, 7(4), 302-314. doi: 10.2174/157015909790031229 Miller, R. (2009). Mechanisms of action of antipsychotic drugs of different classes, refractoriness to therapeutic effects of classical neuroleptics, and individual variation in sensitivity to their actions: PART II. Current Neuropharmacology, 7(4), 315-330. doi: 10.2174/157015909790031184 Miller, S. D., Russell, J. C., MacInnes, H. E., Abdelkrim, J., & Fewster, R. M. (2010). Multiple paternity in wild populations of invasive Rattus species. New Zealand Journal of Ecology, Advance Online Publication. Milne, T. J., Ichim, I., Patel, B., McNaughton, A., & Meikle, M. C. (2009). Induction of osteopenia during experimental tooth movement in the rat: Alveolar bone remodelling and the mechanostat theory. European Journal of Orthodontics, 31(3), 221-231. doi: 10.1093/ejo/cjp032

Division of HEALTH SCIENCES 121 Mishra, P., & Stringer, M. D. (2010). Sciatic nerve injury from intramuscular injection: A persistent and global problem. International Journal of Clinical Practice, 64(11), 1573-1579. doi: 10.1111/j.1742-1241.2009.02177.x Moore, A. E., Jeffery, R., Gray, A., & Stringer, M. D. (2010). An anatomical ultrasound study of the long posterior sacro-iliac ligament. Clinical Anatomy, Advance Online Publication. doi: 10.1002/ca.21039 Negro, S. S., Caudron, A. K., Dubois, M., Delahaut, P., & Gemmell, N. J. (2010). Correlation between male social status, testosterone levels, and parasitism in a dimorphic polygynous mammal. PLoS ONE, 5(9), e12507. doi: 10.1371/journal. pone.0012507 Nerad, L., Liu, P., & Bilkey, D. K. (2009). Bilateral NMDA lesions centered on the postrhinal cortex have minimal effects on hippocampal place cell firing. Hippocampus, 19(3), 221-227. doi: 10.1002/hipo.20517 Oskam, C. L., Premachandra, I. M., & Dias, G. J. (2010). Bizygomatic breadth determination in damaged skulls. International Journal of Osteoarchaeology, 20(5), 540-548. doi: 10.1002/oa.1087

Oswald, M. J., Oorschot, D. E., Schulz, J. M., Lipski, J., & Reynolds, J. N. J. (2009). IH current generates the afterhyperpolarisation following activation of subthreshold cortical synaptic inputs to striatal cholinergic interneurons. Journal of Physiology, 587(24), 5879-5897. doi: 10.1113/jphysiol.2009.177600 Peplow, P. V., Chung, T-Y., & Baxter, G. D. (2010). Laser photobiomodulation of proliferation of cells in culture: A review of human and animal studies. Photomedicine and Laser Surgery, 28(Suppl. 1), S3-S40. doi: 10.1089/pho.2010.2771 Peplow, P. V., Chung, T-Y., & Baxter, G. D. (2010). Laser photobiomodulation of wound healing: A review of experimental studies in mouse and rat animal models. Photomedicine and Laser Surgery, 28(3), 291-325. doi: 10.1089/pho.2008.2446 Peplow, P. V., Dias, G. J., Teixeira, F., & Kelly, R. J. (2009). Tissue reaction to matrices of reconstituted keratin polymer implanted subcutaneously in sheep. Journal of Biomedical Materials Research, 89A(1), 255-265. doi: 10.1002/jbm.a.32038 Petrone, L., Easingwood, R., Barker, M. F., & McQuillan, A. J. (2010). In situ ATR-IR spectroscopic and electron microscopic analyses of settlement secretions of Undaria pinnatifida kelp spores. Journal of the Royal Society Interface, Advance Online Publication. doi: 10.1098/rsif.2010.0316 Petrone, L., Ragg, N. L. C., Girvan, L., & McQuillan, A. J. (2009). Scanning electron microscopy and energy dispersive x-ray microanalysis of Perna canaliculus mussel larvae adhesive secretion. The Journal of Adhesion, 85(2/3), 78-96. doi: 10.1080/00218460902782055 Prasad, P. D., Stanton, J-A. L., & Assinder, S. J. (2010). Expression of the actin-associated protein transgelin (SM22) is decreased in prostate cancer. Cell and Tissue Research, 339(2), 337-347. doi: 10.1007/s00441-009-0902-y Prasetyo, R., Farmer, P., McLennan, I., Southwell, B., & Hutson, J. (2009). Mullerian-inhibiting substance deficiency in transgenic mice interferes with postnatal germ cell development: Clues for understanding infertility in cryptorchidism. Journal of Pediatric Surgery, 44(12), 2335-2338. doi: 10.1016/j.jpedsurg.2009.07.058 Prost, S., Knapp, M., Flemmig, J., Hufthammer, A. K., et al. (2010). A phantom extinction? New insights into extinction dynamics of the Don-hare Lepus tanaiticus. Journal of Evolutionary Biology, 23(9), 2022-2029. doi: 10.1111/j.1420- 9101.2010.02062.x Prost, S., Smirnov, N., Fedorov, V. B., ..., Knapp, M., & Hofreiter, M. (2010). Influence of climate warming on arctic mammals? New insights from ancient DNA studies of the collared lemming Dicrostonyx torquatus. PLoS ONE, 5(5), e10447. doi: 10.1371/journal.pone.0010447 Quennell, J. H., Mulligan, A. C., Tups, A., Liu, X., Phipps, S. J., Kemp, C. J., Herbison, A. E., Grattan, D. R., & Anderson, G. M. (2009). Leptin indirectly regulates gonadotropin-releasing hormone neuronal function. Endocrinology, 150(6), 2805-2812. doi: 10.1210/en.2008-1693 Quennell, J. H., Rizwan, M. Z., Relf, H-L., & Anderson, G. M. (2010). Developmental and steroidogenic effects on the gene expression of RFRP and its receptor in the rat brain and pituitary gland. Journal of Neuroendocrinology, 22, 309-316. doi: 10.1111/j.1365-2826.2010.01963.x Radford, G., Kieser, J., Bernal, V., Waddell, J. N., & Forrest, A. (2009). Biomechanical approach to human bitemark reconstruction. Journal of Forensic Odonto-Stomatology, 27(1), 33-36. Rae-Whitcombe, S. M., Kennedy, D., Voyles, M., & Thompson, M. P. (2010). Regulation of the promoter region of the human adiponutrin/PNPLA3 gene by glucose and insulin. Biochemical and Biophysical Research Communications, 402(4), 767-772. doi: 10.1016/j.bbrc.2010.10.106 Rambaud, M., Combroux, I., Haury, J., Moret, J., Machon, N., Zavodna, M., & Pavoine, S. (2009). Relationships between channelization structures, environmental characteristics, and plant commmunities in four French streams in the Seine- Normandy catchment. Journal of the North American Benthological Society, 28(3), 596-610. doi: 10.1899/08-139.1 Rizwan, M. Z., Porteous, R., Herbison, A. E., & Anderson, G. M. (2009). Cells expressing RFamide-related peptide-1/3, the mammalian gonadotropin-inhibitory hormone orthologs, are not hypophysiotropic neuroendocrine neurons in the rat. Endocrinology, 150(3), 1413-1420. doi: 10.1210/en.2008-1287 Rosengrave, P., Montgomerie, R., Metcalf, V. J., McBride, K., & Gemmell, N. J. (2009). Sperm traits in Chinook salmon depend upon activation medium: Implications for studies of sperm competition in fishes. Canadian Journal of Zoology, 87(10), 920-927. doi: 10.1093/hmg/ddp442 Rosengrave, P., Taylor, H., Montgomerie, R., Metcalf, V., McBride, K., & Gemmell, N. J. (2009). Chemical composition of seminal and ovarian fluids of chinook salmon (Oncorhynchus tshawtscha) and their effects on sperm motility traits. Comparative Biochemistry and Physiology, Part A, 152, 123-129. doi: 10.1016/j.cbpa.2008.09.009 Rouet, V., Bogorad, R. L., Kayser, C., ..., Grattan, D. R., et al. (2010). Local prolactin is a target to prevent expansion of basal/ stem cells in prostate tumors. Proceedings of the National Academy of Sciences of the United States of America, 107(34), 15199-15204. doi: 10.1073/pnas.0911651107

122 RESEARCH REPORT 2009/2010 Russell, J. C., Abdelkrim, J., & Fewster, R. M. (2009). Early colonisation population structure of a Norway rat island invasion. Biological Invasions, 11, 1557-1567. doi: 10.1007/s10530-008-9406-z Russell, J. C., Mackay, J. W. B., & Abdelkrim, J. (2009). Insular pest control within a metapopulation context. Biological Conservation, 142(7), 1404-1410. doi: 10.1016/j.biocon.2009.01.032 Ryan, M. M., Mason-Parker, S. E., Tate, W. P., Abraham, W. C., & Williams, J. M. (2010). Rapidly induced gene networks following induction of long-term potentiation at perforant path synapses in vitro. Hippocampus, Advance Online Publication. doi: 10.1002/hipo.20770 Ryan, M. M., Morris, G., Bourne, K., Mockett, B. G., Abraham, W. C., Tate, W. P., & Williams, J. M. (2009). Regulation of gene expression by sAPPa and RER derivative in differentiated neuroblastoma cells. Alzheimer’s and Dementia, 5(4, Suppl. 1), P421. doi: 10.1016/j.jalz.2009.04.938 Salah Kamel, K., Beckert, L. E., & Stringer, M. D. (2009). Novel insights into the elastic and muscular components of the human trachea. Clinical Anatomy, 22(6), 689-697. doi: 10.1002/ca.20841 Salah Kamel, K., Lau, G., & Stringer, M. D. (2009). In vivo and in vitro morphometry of the human trachea. Clinical Anatomy, 22(5), 571-579. doi: 10.1002/ca.20815 Schulz, J. M., Redgrave, P., Mehring, C., Aertsen, A., Clements, K. M., Wickens, J. R., & Reynolds, J. N. J. (2009). Short-latency activation of striatal spiny neurons via subcortical visual pathways. Journal of Neuroscience, 29(19), 6336-6347. doi: 10.1523/jneurosci.4815-08.2009 Scott, R. M., & Buckley, H. R. (2010). Biocultural interpretations of trauma in two prehistoric Pacific Island populations from Papua New Guinea and the Solomon Islands. American Journal of Physical Anthropology, 142(4), 509-518. doi: 10.1002/ ajpa.21250 Scott, R. M., Buckley, H. R., Spriggs, M., Valentin, F., & Bedford, S. (2010). Identification of the first reported Lapita cremation in the Pacific Islands using archaeological, forensic and contemporary burning evidence. Journal Of Archaeological Science, 37(5), 901-909. doi: 10.1016/j.jas.2009.11.020 Shaw, B., Buckley, H., Summerhayes, G., Anson, D., Garling, S., Valentin, F., Mandui, H., Stirling, C., & Reid, M. (2010). Migration and mobility at the Late Lapita site of Reber-Rakival (SAC), Watom Island using isotope and trace element analysis: A new insight into Lapita interaction in the Bismarck Archipelago. Journal Of Archaeological Science, 37(3), 605- 613. doi: 10.1016/j.jas.2009.10.025 Shaw, B. J., Summerhayes, G. R., Buckley, H. R., & Baker, J. A. (2009). The use of strontium isotopes as an indicator of migration in human and pig Lapita populations in the Bismarck Archipelago, Papua New Guinea. Journal of Archaeological Science, 36(4), 1079-1091. doi: 10.1016/j.jas.2008.12.010 Sheard, P. W., Bewick, G. S., Woolley, A. G., Shaw, J., Fisher, L., Fong, S. W., & Duxson, M. J. (2010). Investigation of neuromuscular abnormalities in neurotrophin-3-deficient mice. European Journal of Neuroscience, 31(1), 29-41. doi: 10.1111/j.1460-9568.2009.07032.x Sizemore, R. J., Reynolds, J. N. J., & Oorschot, D. E. (2010). Number and type of synapses on the distal dendrite of a rat striatal cholinergic interneuron: A quantitative, ultrastructural study. Journal of Anatomy, 217, 223-235. doi: 10.1111/j.1469- 7580.2010.01264.x Smith, A. M., & Girvan, E. (2010). Understanding a bimineralic bryozoan: Skeletal structure and carbonate mineralogy of Odontionella cyclops (Foveolariidae: Cheilostomata: Bryozoa) in New Zealand. Palaeogeography, Palaeoclimatology, Palaeoecology, 289(1-4), 113-122. doi: 10.1016/j.palaeo.2010.02.022 Soal, S., Pollard, M., Burland, G., Lissaman, R., Wafer, M., & Stringer, M. D. (2010). Rapid ultrathin slice plastination of embalmed specimens with minimal tissue loss. Clinical Anatomy, 23, 539-544. doi: 10.1002/ca.20972 Staiger, M. P., Kolbeinsson, I., Kirkland, N., Nguyen, T., Dias, G., & Woodfield, T. B. F. (2010). Synthesis of topologically- ordered open-cell porous magnesium. Materials Letters, Advance Online Publication. doi: 10.1016/j.matlet.2010.08.049 Steeves, T. E., Maloney, R. F., Hale, M. L., Tylianakis, J. M., & Gemmell, N. J. (2010). Genetic analyses reveal hybridization but no hybrid swarm in one of the world’s rarest birds. Molecular Ecology, 19(23), 5090-5100. doi: 10.1111/j.1365- 294X.2010.04895.x Stiller, M., Baryshnikov, G., Bocherens, H., d’Anglade, A. G., Hilpert, B., ..., & Knapp, M. (2010). Withering away: 25,000 years of genetic decline preceded cave bear extinction. Molecular Biology and Evolution, 27(5), 975-978. doi: 10.1093/molbev/ msq083 Stiller, M., Knapp, M., Stenzel, U., Hofreiter, M., & Meyer, M. (2009). Direct multiplex sequencing (DMPS): A novel method for targeted high-throughput sequencing of ancient and highly degraded DNA. Genome Research, 19, 1843-1848. doi: 10.1101/gr.095760.109 Stringer, M. D., & Ahmadi, O. (2009). Famous discoveries by medical students. ANZ Journal of Surgery, 79, 901-908. Summerhayes, G., Matisoo-Smith, E., Mandui, H., Allen, J., Specht, J., Hogg, N., & McPherson, S. (2010). Tamuarawai (EQS): An Early Lapita site on Emirau, New Ireland, PNG. Journal of Pacific Archaeology, 1(2), 62-75. Sutherland, K. R., Alsop, B., McNaughton, N., Hyland, B. I., Tripp, G., & Wickens, J. R. (2009). Sensitivity to delay of reinforcement in two animal models of attention deficit hyperactivity disorder (ADHD). Behavioural Brain Research, 205(2), 372-376. doi: 10.1016/j.bbr.2009.07.011 Szawka, R. E., Ribeiro, A. B., Leite, C. M., Helena, C. V. V., Franci, C. R., Anderson, G. M., Hoffman, G. E., & Anselmo-Franci, J. A. (2010). Kisspeptin regulates prolactin release through hypothalamic dopaminergic neurons. Endocrinology, 151, 3247- 3257. doi: 10.1210/en.2009-1414 Tahir, N., Ramsden, W. H., & Stringer, M. D. (2009). Tracheobronchial anatomy and the distribution of inhaled foreign bodies in children. European Journal of Pediatrics, 168(3), 289-295. doi: 10.1007/s00431-008-0751-9

Division of HEALTH SCIENCES 123 Tayles, N., Domett, K., & Halcrow, S. (2009). Can dental caries be interpreted as evidence of farming? The Asian experience. Frontiers of Oral Biology, 13, 162-166. doi: 10.1159/000242411 Taylor, D. R., Palmay, R., Cowan, J. O., & Herbison, G. P. (2010). Long term performance characteristics of an electrochemical nitric oxide analyser. Respiratory Medicine, Advance Online Publication. doi: 10.1016/j.rmed.2010.09.001 Tenorio, G., Connor, S. A., Guévremont, D., Abraham, W. C., Williams, J., O’Dell, T. J., & Nguyen, P. V. (2010). ‘Silent’ priming of translation-dependent LTP by b-adrenergic receptors involves phosphorylation and recruitment of AMPA receptors. Learning and Memory, 17(12), 627-638. doi: 10.1101/lm.1974510 Thoresen, M., Hobbs, C. E., Wood, T., Chakkarapani, E., & Dingley, J. (2009). Cooling combined with immediate or delayed xenon inhalation provides equivalent long-term neuroprotection after neonatal hypoxia-ischemia. Journal of Cerebral Blood Flow and Metabolism, 29, 707-714. doi: 10.1038/jcbfm.2008.163 Thu, D. C. V., Oorschot, D. E., Tippett, L. J., Nana, A. L., Hogg, V. M., Synek, B. J., et al. (2010). Cell loss in the motor and cingulate cortex correlates with symptomatology in Huntington’s disease. Brain, 133(4), 1094-1110. doi: 10.1093/brain/ awq047 Tups, A., Anderson, G. M., Rizwan, M., Augustine, R. A., Chaussade, C., Shepherd, P. R., & Grattan, D. R. (2010). Both p110a and p110b isoforms of phosphatidylinositol 3-OH-kinase are required for insulin signalling in the hypothalamus. Journal of Neuroendocrinology, 22(6), 534-542. doi: 10.1111/j.1365-2826.2010.01975.x Valentin, F., Bedford, S., Buckley, H. R., & Spriggs, M. (2010). Lapita burial practices: Evidence for complex body and bone treatment at the Teouma Cemetery, Vanuatu, Southwest Pacific. Journal of Island and Coastal Archaeology, 5(2), 212-235. doi: 10.1080/15564891003648092 Valentin, F., Buckley, H. R., Herrscher, E., Kinaston, R., Bedford, S., Spriggs, M., Hawkins, S., & Neal, K. (2010). Lapita subsistence strategies and food consumption patterns in the community of Teouma (Efate, Vanuatu). Journal Of Archaeological Science, 37, 1820-1829. doi: 10.1016/j.jas.2010.01.039 Valentin, F., Spriggs, M., Bedford, S., & Buckley, H. (2009). Une analyse diachronique des pratiques funéraires préhistoriques du centre du Vanuatu. Journal de la Société des Océanistes, 128, 39-52. Vanpé, C., Buschiazzo, E., Abdelkrim, J., Morrow, G., Nicol, S. C., & Gemmell, N. J. (2009). Development of microsatellite markers for the short-beaked echidna using three different approaches. Australian Journal of Zoology, 57(3-4), 219-224. doi: 10.1071/zo09033 Waddell, J. N., Girvan, L., Aarts, J. M., Wu, W., & Swain, M. V. (2010). Elemental composition of imported porcelain-fused-to- metal crowns: A pilot study. New Zealand Dental Journal, 106(2), 50-54. Walker, R., Spronken-Smith, R., Bond, C., McDonald, F., Reynolds, J., & McMartin, A. (2010). The impact of curriculum change on health sciences first year students’ approaches to learning. Instructional Science, 38(6), 707-722. doi: 10.1007/ s11251-009-9092-y Wang, P-Y., Protheroe, A., Clarkson, A. N., Imhoff, F., Koishi, K., & McLennan, I. S. (2009). Müllerian inhibiting substance contributes to sex-linked biases in the brain and behavior. PNAS, 106(17), 7203-7208. doi: 10.1073/pnas.0902253106 Wasterlain, S. N., & Dias, G. J. (2009). Amelogenesis imperfecta in an early 20th century population from central Portugal. International Journal of Osteoarchaeology, 19(3), 424-435. doi: 10.1002/oa.972 White, D. J., & Gemmell, N. J. (2009). Can indirect tests detect a known recombination event in human mtDNZ? Molecular Biology and Evolution, 26(7), 1435-1439. doi: 10.1093/molbev/msp073 Willis, A., & Tayles, N. (2009). Field anthropology: Application to burial contexts in prehistoric Southeast Asia. Journal Of Archaeological Science, 36(2), 547-554. doi: 10.1016/j.jas.2008.10.010 Wilson, M. T., Barry, M., Reynolds, J. N. J., Crump, W. P., Steyn-Ross, D. A., Steyn-Ross, M. L., & Sleigh, J. W. (2010). An analysis of the transitions between down and up states of the cortical slow oscillation under urethane anaesthesia. Journal of Biological Physics, 36(3), 245-259. doi: 10.1007/s10867-009-9180-x Wittmann, W., Schunk, E., Rosskothen, I., Gaburro, S., Singewald, N., Herzog, H., & Schwarzer, C. (2009). Prodynorphin-derived peptides are critical modulators of anxiety and regulate neurochemistry and corticosterone. Neuropsychopharmacology, 34(3), 775-785. doi: 10.1038/npp.2008.142 Yang, J. J., Larsen, C. M., Grattan, D. R., & Erskine, M. S. (2009). Mating-induced neuroendocrine responses during pseudopregnancy in the female mouse. Journal of Neuroendocrinology, 21(1), 30-39. doi: 10.1111/j.1365-2826.2008.01803.x Young, A. G., McQuillan, A. J., & Green, D. P. (2009). In situ IR spectroscopic studies of the avidin-biotin bioconjugation reaction on CdS particle films. Langmuir, 25(13), 7416-7423. doi: 10.1021/la900350s Zavodna, M., Bottin, L., Lambourdiere, J., & Machon, N. (2009). Development and characterization of microsatellite markers for Arenaria grandiflora L. (Caryophyllaceae). Molecular Ecology Resources, 9, 628-630. Zhang, J., & Stringer, M. D. (2010). Ophthalmic and facial veins are not valveless. Clinical and Experimental Ophthalmology, 38(5), 502-510. doi: 10.1111/j.1442-9071.2010.02325.x Zheng, Y., Begum, S., Zhang, C., Fleming, K., Masumura, C., Zhang, M., Smith, P., & Darlington, C. (2010). Increased BrdU incorporation reflecting DNA repair, neuronal de-differentiation or possible neurogenesis in the adult cochlear nucleus following bilateral cochlear lesions in the rat. Experimental Brain Research, Advance Online Publication. doi: 10.1007/ s00221-010-2491-0 Zheng, Y., Vagal, S., Zhu, X-X., de Waele, C., Smith, P. F., Wang, G., Zhang, M., & Darlington, C. L. (2010). The effects of the Chinese herbal medicine EMF01 on salicylate-induced tinnitus in rats. Journal of Ethnopharmacology, 128, 545-548. doi: 10.1016/j.jep.2010.01.053

124 RESEARCH REPORT 2009/2010 Journal - Research Other Clarkson, A. N., & Carmichael, S. T. (2009). Cortical excitability and post-stroke recovery. Biochemical Society Transactions, 37(6), 1412-1414. doi: 10.1042/BST0371412 Jones, D. G., & Whitaker, M. I. (2009). Religious traditions and embryo science [Commentary]. American Journal of Bioethics, 9(11), 41-43. doi: 10.1080/15265160903197697 Jones, D. G., & Whitaker, M. I. (2010). Cadavers, plastinates, and mummies [Letter to the editor]. Clinical Anatomy, 23(1), 125- 126. doi: 10.1002/ca.20894 McGrath, C., Nicholson, H., & Hurst, P. (2010). Branch blockade of the dorsal sacral rami [Letter to the editor]. Pain Medicine, 11(2), 281-282. doi: 10.1111/j.1526-4637.2009.00780.x Pollard, M., Soal, S., & Stringer, M. D. (2010). Reply: General considerations regarding the thin slice plastination technique [Letter to the editor]. Clinical Anatomy, 23, 737-738. doi: 10.1002/ca.21012 Stringer, M. D., & Becker, I. (2010). Colombo and the clitoris. European Journal of Obstetrics & Gynecology and Reproductive Biology, 151, 130-133. doi: 10.1016/j.ejogrb.2010.04.007

Journal - Professional & Other Non-Research Articles Al-Shaqsi, S., & Stringer, M. D. (2010). Focused assessment sonography for trauma: A fast overview of FAST: An ultrasound technique to assess patients with trauma. Student BMJ, 18, c1540. doi: 10.1136/sbmj.c1540 Becker, I., Woodley, S. J., & Baxter, G. D. (2009). Response to “The beginning of the evidence-based morphology” [Letter to the editor]. Clinical Anatomy, 22(7), 854. doi: 10.1002/ca.20858 Cornwall, J. (2010). [Review of the book Functional anatomy of the spine]. New Zealand Journal of Physiotherapy, 38(2), 81. Cornwall, J., & Stringer, M. D. (2009). The wider importance of cadavers: Educational and research diversity from a body bequest program. Anatomical Sciences Education, 2(5), 234-237. doi: 10.1002/ase.103 Grattan, D. (2009). Editorial. Journal of Neuroendocrinology, 21(1), 1. doi: 10.1111/j.1365-2826.2008.01808.x Grattan, D. R. (2010). [Editorial]. Journal of Neuroendocrinology, 22, 629. doi: 10.1111/j.1365-2826.2010.02036.x Jones, D. G. (2009). [Review of the book Sacred cells? Why Christians should support stem cell research]. Perspectives on Science and Christian Faith, 61(4), 261-262. Jones, D. G. (2009). [Review of the book The big questions in science and religion]. Theological Book Review, 21(2), 10. Jones, D. G. (2009). [Review of the book The cell’s design: How chemistry reveals the Creator’s artistry]. Theological Book Review, 21(1), 14-15. Jones, D. G. (2009). [Review of the book The sanctity of human life]. Theological Book Review, 21(2), 93-94. Jones, G. (2010). Heavenly bodies: The future of surgical enhancement. Third Way, (September), 13. Miller, R. (2009). [Review of the book Doctoring the mind: Why psychiatric treatments fail]. Psychological Medicine, 40(2), 347- 501. doi: 10.1017/S0033291709991681 Miller, R. (2009). [Review of the book Schizophrenia: The positive perspective: Explorations at the outer reaches of human experience]. Psychological Medicine, 39(6), 1047-1048. doi: 10.1017/S0033291709005212 Stringer, M. (2009). [Review of the book Speaking for the dead: The human body in biology and medicine. (2nd edition)]. New Zealand Medical Journal, 122(1296). Retrieved from http://www.nzma.org.nz/journal/122-1296/3653/

Otago School of Medical Sciences Department of Biochemistry

Chapter in Book - Research Day, R. C. (2010). Laser microdissection of paraffin-embedded plant tissues for transcript profiling. In L. Hennig & C. Köhler (Eds.), Plant development biology: Methods and protocols (pp. 321-346). New York: Spinger. doi: 10.1007/978-1-60761-765- 5_22 Dearden, P. K., Duncan, E. J., & Wilson, M. J. (2010). The honeybee Apis mellifera. Emerging model organisms: A laboratory manual (Vol. 2) (pp. 223-246). Cold Spring Harbor, NY: Cold Spring Harbor Press. Eaton-Rye, J. (2010). Construction of gene interruptions and gene deletions in the cyanobacterium Synechocystis sp. strain PCC 6803. In R. Carpentier (Ed.), Photosynthesis Research Protocols (2nd ed.). (pp. 295-312). NY: Springer. doi: 10.1007/978-1-60761-925-3 von Zychlinski, A., & Gruissem, W. (2009). Preparation and analysis of plastid proteomes by 2DE. In D. Sheehan & R. Tyther (Eds.), Two-dimensional electrophoresis protocols (Vol. 519) (pp. 205-220). Totowa, NJ: Humana Press. doi: 10.1007/978-1- 59745-281-6_13

Journal - Research Article Anjomshoaa, A., Nasri, S., Humar, B., McCall, J. L., Chatterjee, A., Yoon, H-S., McNoe, L., Black, M. A., & Reeve, A. E. (2009). Slow proliferation as a biological feature of colorectal cancer metastasis. British Journal of Cancer, 101(5), 822-828. doi: 10.1038/sj.bjc.6605229 Ariazi, E. A., Brailoiu, E., Yerrum, S., ..., Black, M. A., et al. (2010). The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells. Cancer Research, 70(3), 1184-1194. doi: 10.1158/0008-5472. CAN-09-3068

Division of HEALTH SCIENCES 125 Baek, J. h., Zheng, Y., Darlington, C. L., & Smith, P. (2010). Evidence that spatial memory deficits following bilateral vestibular deafferentation in rats are probably permanent. Neurobiology of Learning and Memory, 94(3), 402-413. doi: 10.1016/j. nlm.2010.08.007

Baek, J. H., Zheng, Y., Darlington, C. L., & Smith, P. F. (2010). Cannabinoid CB1 receptor expression and affinity in the rat hippocampus following bilateral vestibular deafferentation. Neuroscience Letters, Advance Online Publication. doi: 10.1016/j.neulet.2010.10.050 Bentley, R. W., Cleynen, I., Gearry, R. B., Barclay, M. L., Rutgeerts, P., Merriman, T. R., Ferrante, M., Roberts, R. L., & Vermeire, S. (2010). Evidence that glioma-associated oncogene homolog 1 is not a universal risk gene for inflammatory bowel disease in Caucasians. Genes & Immunity, Advance Online Publication. doi: 10.1038/gene.2010.15 Bentley, R. W., Pearson, J., Gearry, R. B., Barclay, M. L., McKinney, C., Merriman, T. R., & Roberts, R. L. (2010). Association of higher DEFB4 genomic copy number with Crohn’s disease. American Journal of Gastroenterology, 105(2), 354-359. doi: 10.1038/ajg.2009.582 Bernhardt, H. S., & Tate, W. P. (2010). The transition from noncoded to coded protein synthesis: Did coding mRNAs arise from stability-enhancing binding partners to tRNA? Biology Direct, 5, 16. doi: 10.1186/1745-6150-5-16 Bird, S. D., Walker, R. J., & Legge, M. (2009). l-Cysteine improves survival and growth of mesothelial cells after freezing. Cell Biology International, 33(11), 1155-1164. doi: 10.1016/j.cellbi.2009.08.003 Bishop, P. J., Speare, R., Poulter, R., Butler, M., Speare, B. J., Hyatt, A., Olsen, V., & Haigh, A. (2009). Elimination of the amphibian chytrid fungus Batrachochytrium dendrobatidis by Archey’s frog leiopelma archeyi. Diseases of Aquatic Organisms, 84(1), 9-15. doi: 10.3354/dao02028 Bokor, A. A. M., van Kan, J. A. L., & Poulter, R. T. M. (2010). Sexual mating of Botrytis cinerea illustrates prp8 intein heg activity. Fungal Genetics and Biology, 47(4), 392-398. doi: 10.1016/j.fgb.2010.01.003 Bouwer, A. L., Netter, P., Kemp, R. A., & McLellan, A. D. (2010). A defined serum-free medium useful for monitoring anti- melanoma responses induced by dendritic cell immunotherapy. Journal of Immunological Methods, 352, 178-181. doi: 10.1016/j.jim.2009.11.001 Brace, R. J., Sorrenson, B., Sviridov, D., & McCormick, S. P. A. (2010). A gel-based method for purification of apolipoprotein A-I from small volumes of plasma. Journal of Lipid Research, Advance Online Publication. doi: 10.1194/jlr.D008300 Broom, J. E. S., Nelson, W. A., Farr, T. J., Phillips, L., & Clayton, M. (2010). Relationships of the Porphyra (Bangiales, Rhodophyta) flora of the Falkland Islands: A molecular survey using rbcL and nSSU sequence data. Australian Systematic Botany, 23(1), 27-37. doi: 10.1071/sb09033 Burut-Archanai, S., Incharoensakdi, A., & Eaton-Rye, J. J. (2009). The extended N-terminal region of SphS is required for detection of external phosphate levels in Synechocystis sp. PCC 6803. Biochemical and Biophysical Research Communications, 378(3), 383-388. doi: 10.1016/j.bbrc.2008.11.012 Cardno, T. S., Poole, E. S., Mathew, S. F., Graves, R., & Tate, W. P. (2009). A homogeneous cell-based bicistronic fluorescence assay for high-throughput identification of drugs that perturb viral gene recoding and read-through of nonsense stop codons. RNA, 15(8), 1614-1621. doi: 10.1261/rna.1586709 Chee Liew, L., Hecht, V., Laurie, R. E., Knowles, C. L., Vander Schoor, J. K., Macknight, R. C., & Weller, J. L. (2009). DIE NEUTRALIS and LATE BLOOMER 1 contribute to regulation of the pea circadian clock. Plant Cell, 21(10), 3198-3211. doi: 10.1105/tpc.109.067223 Chen, C., Krause, K., & Pettitt, B. M. (2009). Advantage of being a dimer for Serratia marcescens endonuclease. Journal of Physical Chemistry B, 113(2), 511-521. doi: 10.1021/jp8057838 Claasen, A. M., Guévremont, D., Mason-Parker, S. E., Bourne, K., Tate, W. P., Abraham, W. C., & Williams, J. M. (2009). Secreted amyloid precursor protein-a upregulates synaptic protein synthesis by a protein kinase G-dependent mechanism. Neuroscience Letters, 460, 92-96. doi: 10.1016/j.neulet.2009.05.040 Clarke, S. M., Cristescu, S. M., Miersch, O., Harren, F. J. M., Wasternack, C., & Muir, L. A. J. (2009). Jasmonates act with salicylic acid to confer basal thermotolerance in Arabidopsis thaliana. New Phytologist, 182(1), 175-187. doi: 10.1111/j.1469-8137.2008.02735.x Couñago, R. M., Davlieva, M., Strych, U., Hill, R. E., & Krause, K. L. (2009). Biochemical and structural characterization of alanine racemase from Bacillus anthracis (ames). BMC Structural Biology, 9, 53. doi: 10.1186/1472-6807-9-53 Couñago, R. M., Fleming, S. B., Mercer, A. A., & Krause, K. L. (2010). Crystallization and preliminary X-ray analysis of the chemokine-binding protein from orf virus (Poxviridae). Acta Crystallographica, F66, 819-823. doi: 10.1107/ S1744309110018166 Crump, R. J., Fitzgerald, R. P., & Legge, M. (2010). ‘Going-to-have-cancerness’: A study of living with increased risk of BRCA1 and BRCA2 mutations for six South Island women. Journal of Primary Health Care, 2(4), 311-317. Dalbeth, N., & Merriman, T. (2009). Crystal ball gazing: New therapeutic targets for hyperuricaemia and gout. Rheumatology, 48(3), 222-226. doi: 10.1093/rheumatology/ken460 Day, R. C., Mueller, S., & Macknight, R. C. (2009). Identification of cytoskeleton-associated genes expressed during arabidopsis syncytial endosperm development. Plant Signalling and Behavior, 4(9), 883-886. Dearden, P. K., Duncan, E. J., & Wilson, M. J. (2009). Fixation and storage of honeybee (Apis mellifera) tissues. Cold Spring Harbor Protocols, 4(6). doi: 10.1101/pdb.prot5224 Dearden, P. K., Duncan, E. J., & Wilson, M. J. (2009). Immunohistochemistry on honeybee (Apis mellifera) embryos. Cold Spring Harbor Protocols, 4(6), 15596095. doi: 10.1101/pdb.prot5227 Dearden, P. K., Duncan, E. J., & Wilson, M. J. (2009). In situ hybridization of sectioned honeybee (Apis mellifera) tissues. Cold Spring Harbor Protocols, 4(6). doi: 10.1101/pdb.prot5226

126 RESEARCH REPORT 2009/2010 Dearden, P. K., Duncan, E. J., & Wilson, M. J. (2009). Rna interference (RNAi) in honeybee (Apis mellifera) embryos. Cold Spring Harbor Protocols, 4(6). doi: 10.1101/pdb.prot5228 Dearden, P. K., Duncan, E. J., & Wilson, M. J. (2009). The honeybee Apis mellifera. Cold Spring Harbor Protocols, 4(6). doi: 10.1101/pdb.emo123 Dearden, P. K., Duncan, E. J., & Wilson, M. J. (2009). Whole-mount in situ hybridization of honeybee (Apis mellifera) tissues. Cold Spring Harbor Protocols, 4(6). doi: 10.1101/pdb.prot5225 Dewson, G., Kratina, T., Czabotar, P., Day, C. L., Adams, J. M., & Kluck, R. M. (2009). Bak activation for apoptosis involves oligomerization of dimers via their a6 helices. Molecular Cell, 36(4), 696-703. doi: 10.1016/j.molcel.2009.11.008 Dickson, G. C., Poulter, R., Maas, E. W., Probert, P. K., & Kieser, J. A. (2010). Marine bacterial succession as a potential indicator of postmortem submersion interval. Forensic Science International, Advance Online Publication. doi: 10.1016/j. forsciint.2010.10.016 Donaldson, A. E., Walker, N. K., Lamont, I. L., Cordiner, S. J., & Taylor, M. C. (2010). Characterising the dynamics of expirated bloodstain pattern formation using high-speed digital video imaging. International Journal of Legal Medicine, Advance Online Publication. doi: 10.1007/s00414-010-0498-5 Donaldson, A., Taylor, M. C., Cordiner, S. J., & Lamont, I. L. (2010). Using oral microbial DNA analysis to identify expirated bloodspatter. International Journal of Legal Medicine, Advance Online Publication. doi: 10.1007/s00414-010-0426-8 Dong, C., Poulter, R. T., & Han, J. S. (2009). Line-like retrotransposition in Saccharomyces cerevisiae. Genetics, 181(1), 301-311. Duncan, E. J., & Dearden, P. K. (2010). Evolution of a genomic regulatory domain: The role of gene co-option and gene duplication in the enhancer of split complex. Genome Research, 20, 917-928. doi: 10.1101/gr.104794.109 Ehimen, E. A., Sun, Z. F., Carrington, C. G., Birch, E. J., & Eaton-Rye, J. J. (2010). Anaerobic digestion of microalgae residues resulting from the biodiesel production process. Applied Energy, Advance Online Publication. doi: 10.1016/j. apenergy.2010.10.020 Empson, R. M., Turner, P. R., Nagaraja, R. Y., Beesley, P. W., & Knöpfel, T. (2010). Reduced expression of the Ca2+ transporter protein PMCA2 slows Ca2+ dynamics in mouse cerebellar Purkinje neurons and alters the precision of motor coordination. Journal of Physiology, 588(6), 907-922. doi: 10.1113/jphysiol.2009.182196 Feltham, R., Moulin, M., Vince, J. E., ..., Day, C. L., Vaux, D. L., & Silke, J. (2010). Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding. Journal of Biological Chemistry, 285(23), 17525-17536. doi: 10.1074/ jbc.M109.087635 Fenby, N., Pu, H., Pennell, R., Praekelt, U., Day, R., & Scott, R. (2010). An uncoupling screen for autonomous embryo mutants in Arabidopsis thaliana. Sexual Plant Reproduction, Advance Online Publication. doi: 10.1007/s00497-010-0142-z Fitzgerald, R. C., Hardwick, R., Huntsman, D., Carneiro, F., Guilford, P., Blair, V., et al. (2010). Hereditary diffuse gastric cancer: Updated consensus guidelines for clinical management and directions for future research. Journal of Medical Genetics, 47(7), 436-444. doi: 10.1136/jmg.2009.074237 Fukuzawa, R., Anaka, M. R., Weeks, R. J., Morison, I. M., & Reeve, A. E. (2009). Canonical WNT signalling determines lineage specificity in Wilms tumour. Oncogene, 28(8), 1063-1075. doi: 10.1038/onc.2008.455 Fukuzawa, R., Holman, S. K., Chow, C. W., Savarirayan, R., Reeve, A. E., & Robertson, S. P. (2010). WTX mutations can occur both early and late in the pathogenesis of Wilms tumour. Journal of Medical Genetics, Advance Online Publication. doi: 10.1136/jmg.2010.080663 Garside, M. L., Turner, P. R., Austen, B., Strehler, E. E., Beesley, P. W., & Empson, R. M. (2009). Molecular interactions of the plasma membrane calcium ATPase 2 at pre- and post-synaptic sites in rat cerebellum. Neuroscience, 162(2), 383-395. doi: 10.1016/j.neuroscience.2009.04.059 Gerardo, N. M., Altincicek, B., Anselme, C., Atamian, H., Barribeau, S. M., de Vos, M., Duncan, E. J., et al. (2010). Immunity and other defenses in pea aphids, Acyrthosiphon pisum. Genome Biology, 11(2), R21. doi: 10.1186/gb-2010-11-2-r21 Ghosh, A., Ali, M. A., Selvanesan, L., & Dias, G. J. (2010). Structure-function characteristics of the biomaterials based on milk- derived proteins. 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Ulva, Umbraulva and Gemina: Genetic survey of New Zealand taxa reveals diversity and introduced species. European Journal of Phycology, 44(2), 143-154. doi: 10.1080/09670260802422477 Hohmann-Marriott, M. F., & Roberson, R. W. (2009). Exploring photosynthesis by electron tomography. Photosynthesis Research, 102(2-3), 177-188. doi: 10.1007/s11120-009-9452-0 Hohmann-Marriott, M. F., Sousa, A. A., Azari, A. A., Glushakova, S., Zhang, G., Zimmerberg, J., & Leapman, R. D. (2009). Nanoscale 3D cellular imaging by axial scanning transmission electron tomography. Nature Methods, 6(10), 729-731. doi: 10.1038/nmeth.1367 Hohmann-Marriott, M. F., Takizawa, K., Eaton-Rye, J. J., Mets, L., & Minagawa, J. (2010). The redox state of the plastoquinone pool directly modulates minimum chlorophyll fluorescence yield in Chlamydomonas reinhardtii. FEBS Letters, 584, 1021- 1026. doi: 10.1016/j.febslet.2010.01.052

Division of HEALTH SCIENCES 127 Hollis-Moffatt, J. E., Chen-Xu, M., Topless, R., Dalbeth, N., Gow, P. J., Harrison, A. A., Highton, J., Jones, P. B. B., Nissen, M., Smith, M. D., van Rij, A., Jones, G. T., Stamp, L. K., & Merriman, T. R. (2010). Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: Confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance. Arthritis Research & Therapy, 12(3), R116. doi: 10.1186/ar3053 Hollis-Moffatt, J. E., Merriman, M. E., Rodger, R. A., Rowley, K. A., Chapman, P. T., Dalbeth, N., Gow, P. J., Harrison, A. A., Highton, J., Jones, P. B. B., O’Donnell, J. L., Stamp, L. K., & Merriman, T. R. (2009). Evidence for association of an interleukin 23 receptor variant independent of the R381Q variant with rheumatoid arthritis. Annals of the Rheumatic Diseases, 68(8), 1340-1344. doi: 10.1136/ard.2008.090142 Hollis-Moffatt, J. E., Rowley, K. A., Phipps-Green, A. J., Merriman, M. E., Dalbeth, N., Gow, P., Harrison, A. A., Highton, J., Jones, P. B. B., Stamp, L. K., Harrison, P., Wordsworth, B. P., & Merriman, T. R. (2009). The ITGAV rs3738919 variant and susceptibility to rheumatoid arthritis in four Caucasian sample sets. Arthritis Research & Therapy, 11, R152. doi: 10.1186/ ar2828 Hollis-Moffatt, J. E., Xu, X., Dalbeth, N., Merriman, M. E., Topless, R., Waddell, C., Gow, P. J., Harrison, A. A., Highton, J., Jones, P. B. B., Stamp, L. K., & Merriman, T. R. (2009). Role of the urate transporter SLC2A9 gene in susceptibility to gout in New Zealand Mäori, Pacific Island, and Caucasian case-control sample sets. Arthritis and Rheumatism, 60(11), 3485- 3492. doi: 10.1002/art.24938 Hueber, P-A., Fukuzawa, R., Elkares, R., Chu, L., Blumentkrantz, M., He, S-J., Anaka, M. R., Reeve, A. E., Eccles, M. R., Jabado, N., Iglesias, D., & Goodyer, P. R. (2009). PAX3 is expressed in the stromal compartment of the developing kidney and in Wilms tumors with myogenic phenotype. Pediatric and Developmental Pathology, 12(5), 347-354. doi: 10.2350/08-05- 0466.1 Humar, B., Blair, V., Charlton, A., More, H., Martin, I., & Guilford, P. (2009). E-cadherin deficiency initiates gastric signet-ring cell carcinoma in mice and man. Cancer Research, 69(5), 2050-2056. International Aphid Genomics Consortium, including Smith, J., Wilson, M., Dearden, P., & Duncan, E. J. (2010). Genome sequence of the pea aphid Acyrthosiphon pisum. PLoS Biology, 8(2), e1000313. doi: 10.1371/journal.pbio.1000313 Isely, N., Lamare, M., Marshall, C., & Barker, M. (2009). Expression of the DNA repair enzyme, photolyase, in developmental tissues and larvae, and in response to ambient UV-R in the Antarctic sea urchin Sterechinus neumayeri. Photochemistry and Photobiology, 85(5), 1168-1176. doi: 10.1111/j.1751-1097.2009.00566.x Jackson, A. P., Gamble, J. A., Yeomans, T., ..., Poulter, R. T., et al. (2009). Comparative genomics of the fungal pathogens Candida dubliniensis and Candida albicans. Genome Research, 19(12), 2231-2244. doi: 10.1101/gr.097501.109 Jackson, S. A., Fagerlund, R. D., Wilbanks, S. M., & Eaton-Rye, J. J. (2010). Crystal structure of PsbQ from Synechocystis sp. PCC 6803 at 1.8 Å: Implications for binding and function in cyanobacterial photosystem II. Biochemistry, 49(13), 2765- 2767. doi: 10.1021/bi100217h Jacobs, G. H., Chen, A., Stevens, S. G., Stockwell, P. A., Black, M. A., Tate, W. P., & Brown, C. M. (2009). Transterm: A database to aid the analysis of regulatory sequences in mRNAs. Nucleic Acids Research, 37(Database issue), D72-D76. doi: 10.1093/ nar/gkn763 Jenkins, Z. A., van Kogelenberg, M., Morgan, T., Jeffs, A., Fukuzawa, R., Pearl, E., ..., & Robertson, S. P. (2009). Germline mutations in WTX cause a sclerosing skeletal dysplasia but do not predispose to tumorigenesis. Nature Genetics, 41(1), 95-100. doi: 10.1038/ng.270 Johnston, P. A., Timmerman-Vaughan, G., Farnden, K. J. F., & Pickering, R. (2009). Marker development and characterisation of Hordeum bulbosum introgression lines: A resource for barley improvement. Theoretical & Applied Genetics, 118(8), 1429-1437. Jones, L. M., & Legge, M. (2009). Biochemical markers of bone activity in active and sedentary spinal cord injured men. New Zealand Journal of Medical Laboratory Science, 63(2), 40-43. Jones, L. M., Meredith-Jones, K., & Legge, M. (2009). The effect of water-based exercise on glucose and insulin response in overweight women: A pilot study. Journal of Women’s Health, 18(10), 1653-1659. doi: 10.1089/jwh.2008.1147 Jones, L. M., Waters, D. L., & Legge, M. (2009). Walking speed at self-selected exercise pace is lower but energy cost higher in older versus younger women. Journal of Physical Activity and Health, 6(3), 327-332. Kafka, A. P., Kleffmann, T., Rades, T., & McDowell, A. (2009). Histidine residues in the peptide d-Lys6-GnRH: Potential for copolymerization in polymeric nanoparticles. Molecular Pharmaceutics, 6(5), 1483-1491. doi: 10.1021/mp900043e Kafka, A. P., Kleffmann, T., Rades, T., & McDowell, A. (2010). Characterization of peptide polymer interactions in poly(alkylcyanoacrylate) nanoparticles: A mass spectrometric approach. Current Drug Delivery, 7(3), 208-215. Kafka, A. P., Kleffmann, T., Rades, T., & McDowell, A. (2010). The application of MALDI TOF MS in biopharmaceutical research. International Journal of Pharmaceutics, Advance Online Publication. doi: 10.1016/j.ijpharm.2010.12.010 Kawai, H., Uwai, S., Hanyuda, T., Nakamura, K., Shimada, S., Broom, J., Nelson, W., & Viard, F. (2009). Origin and dynamics of the introduced populations of Undaria pinnatifida (Phaeophyceae) and detection of introduced populations of Ulva spp. (Ulvophyceae) by the analyses using molecular markers. Japanese Journal of Ecology, 59(2), 145-152. Kho, E. M., McCowan, L. M. E., North, R. A., Roberts, C. T., Chan, E., Black, M. A., Taylor, R. S., Dekker, G. A., & on behalf of the SCOPE Consortium (2009). Duration of sexual relationship and its effect on preeclampsia and small for gestational age perinatal outcome. Journal of Reproductive Immunology, 82(1), 66-73. doi: 10.1016/j.jri.2009.04.011 Kikuchi, N., Arai, S., Yoshida, G., Shin, J-A., Broom, J. E., et al. (2010). Porphyra migitae sp. nov. (Bangiales, Rhodophyta) from Japan. Phycologia, 49(4), 345-354. doi: 10.2216/09-82.1

128 RESEARCH REPORT 2009/2010 Kleffmann, T., Jongkees, S. A. K., Fairweather, G., Wilbanks, S. M., & Jameson, G. N. L. (2009). Mass-spectrometric characterization of two posttranslational modifications of cysteine dioxygenase. Journal of Biological Inorganic Chemistry, 14, 913-921. doi: 10.1007/s00775-009-0504-x Lamont, I. L., Konings, A. F., & Reid, D. W. (2009). Iron acquisition by Pseudomonas aeruginosa in the lungs of patients with cystic fibrosis. Biometals, 22(1), 53-60. doi: 10.1007/s10534-008-9197-9 Ledgerwood, E. C., & Morison, I. M. (2009). Targeting the apoptosome for cancer therapy. Clinical Cancer Research, 15(2), 420-424. doi: 10.1158/1078-0432.CCR-08-1172 Legge, M., Jones, L. M., & McLeod, B. J. (2010). Energy substrate utilization in the common brushtailed possum (Trichosurus vulpecula) using intravenous tolerance tests. Comparative Biochemistry and Physiology, Part B, Advance Online Publication. doi: 10.1016/j.cbpb.2010.10.007 Liew, C. W., Sun, H., Hunter, T., & Day, C. L. (2010). RING domain dimerization is essential for RN4 function. Biochemical Journal, 431(1), 23-29. doi: 10.1042/BJ20100957 Lu, A-T., Salpeter, S. R., Reeve, A. E., Eschrich, S., Johnston, P. G., Barrier, A. J., Bertucci, F., Buckley, N. S., et al. (2009). Gene expression profiles as predictors of poor outcomes in stage II colorectal cancer: A systematic review and meta-analysis. Clinical Colorectal Cancer, 8(4), 207-214. doi: 10.3816/CCC.2009.n.035 Mabbitt, P. D., Rautureau, G. J. P., Day, C. L., Wilbanks, S. M., Eaton-Rye, J. J., & Hinds, M. G. (2009). Solution structure of Psb27 from cyanobacterial photosystem II. Biochemistry, 48(37), 8771-8773. doi: 10.1021/bi901309c Mace, P. D., Shirley, S., & Day, C. L. (2010). Assembling the building blocks: Structure and function of inhibitor of apoptosis proteins. Cell Death and Differentiation, 17, 46-53. doi: 10.1038/cdd.2009.45 Mace, P. D., Smits, C., Vaux, D. L., Silke, J., & Day, C. L. (2010). Asymmetric recruitment of cIAPs by TRAF2. Journal of Molecular Biology, 400, 8-15. doi: 10.1016/j.jmb.2010.04.055 Mai, P. L., Friedlander, M., Tucker, K., ..., Guilford, P., et al. (2010). The International Testicular Cancer Linkage Consortium: A clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred. Urologic Oncology, 28(5), 492-499. doi: 10.1016/j.urolonc.2008.10.004 Ma, L-J., Ibrahim, A. S., Skory, C., Grabherr, M. G., Burger, G., Butler, M., ..., Poulter, R., et al. (2009). Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a whole-genome duplication. PLoS Genetics, 5(7), e1000549. doi: 10.1371/ journal.pgen.1000549 Manning, J. A., Shalini, S., Risk, J. M., Day, C. L., & Kumar, S. (2010). A direct interaction with NEDD1 regulates g-tubulin recruitment to the centrosome. PLoS ONE, 5(3), e9618. doi: 10.1371/journal.pone.0009618 Margueron, R., Justin, N., Ohno, K., Sharpe, M. L., Son, J., et al. (2009). Role of the polycomb protein EED in the propagation of repressive histone marks. Nature, 431, 762-767. doi: 10.1038/nature08398 McKinney, C., Fanciulli, M., Merriman, M. E., Phipps-Green, A., ..., Harrison, A. A., Highton, J., Jones, P. B., Stamp, L. K., ..., & Merriman, T. R. (2010). Association of variation in Fcg receptor 3B gene copy number with rheumatoid arthritis in Caucasian samples. Annals of the Rheumatic Diseases, 69, 1711-1716. doi: 10.1136/ard.2009.123588 McMillan, D. G. G., Velasquez, I., Nunn, B. L., Goodlett, D. R., Hunter, K. A., Lamont, I., Sander, S. G., & Cook, G. M. (2010). Acquisition of iron by alkaliphilic Bacillus species. Applied and Environmental Microbiology, 76(20), 6955-6961. doi: 10.1128/AEM.01393-10 Meredith-Jones, K., Legge, M., & Jones, L. M. (2009). Circuit based deep water running improves cardiovascular fitness, strength and abdominal obesity in older, overweight women: Aquatic exercise intervention in older adults. Medicina Sportiva, 13(1), 5-12. doi: 10.2478/v10036-009-0002-9 Merriman, T. R. (2009). Type 1 diabetes, the A1 milk hypothesis and vitamin D deficiency. Diabetes Research and Clinical Practice, 83(2), 149-156. doi: 10.1016/j.diabres.2008.11.010 Merriman, T. R., & Dalbeth, N. (2010). The genetic basis of hyperuricaemia and gout [Bases génétiques de l’hyperuricémie et de la goutte]. Revue du Rhumatisme Monographies, Advance Online Publication. doi: 10.1016/j.monrhu.2010.06.006 Merriman, T. R., & Dalbeth, N. (2010). The genetic basis of hyperuricaemia and gout. Joint Bone Spine, Advance Online Publication. doi: 10.1016/j.jbspin.2010.02.027 Mettrick, K. A., & Lamont, I. L. (2009). Different roles for anti-sigma factors in siderophore signalling pathways of Pseudomonas aeruginosa. Molecular Microbiology, 74(5), 1257-1271. doi: 10.1111/j.1365-2958.2009.06932.x Milev, M. P., Brown, C. M., & Mouland, A. J. (2010). Live cell visualization of the interactions between HIV-1 Gag and the cellular RNA-binding protein Staufen1. Retrovirology, 7, 41. doi: 10.1186/1742-4690-7-41 Miller, C., Davlieva, M., Wilson, C., White, K. I., Couñago, R., et al. (2010). Experimental evolution of adenylate kinase reveals contrasting strategies toward protein thermostability. Biophysical Journal, 99(3), 887-896. doi: 10.1016/j.bpj.2010.04.076 Nakatani, Y., Lamont, I. L., & Cutfield, J. F. (2010). Discovery and characterisation of a distinctive exo-1,3/1,4-b-glucanase from the marine bacterium Pseudoalteromonas sp. BB1. Applied and Environmental Microbiology, Advance Online Publication. doi: 10.1128/AEM.00758-10 Nasri, S., Anjomshoaa, A., Song, S., Guilford, P., McNoe, L., Black, M., Phillips, V., Reeve, A., & Humar, B. (2010). Oligonucleotide array outperforms SNP array on formalin-fixed paraffin-embedded clinical samples. Cancer Genetics and Cytogenetics, 198(1), 1-6. doi: 10.1016/j.cancergencyto.2009.12.002 Nelson, W. A., & Broom, J. E. S. (2010). The identity of Porphyra columbina (Bangiales, Rhodophyta) originally described from the New Zealand subantarctic islands. Australian Systematic Botany, 23(1), 16-26. doi: 10.1071/sb09032 Nordang, G. B. N., Viken, M. K., Hollis-Moffatt, J. E., Merriman, T. R., Førre, Ø. T., Helgetveit, K., Kvien, T. K., & Lie, B. A. (2009). Association analysis of the interleukin 17A gene in caucasian rheumatoid arthritis patients from Norway and New Zealand. Rheumatology, 48(4), 367-370. doi: 10.1093/rheumatology/ken512

Division of HEALTH SCIENCES 129 Panjaworayan, N., Payungporn, S., Poovorawan, Y., & Brown, C. M. (2010). Identification of an effective siRNA target site and functional regulatory elements, within the hepatitis B virus posttranscriptional regulatory element. Virology Journal, 7, 216. doi: 10.1186/1743-422x-7-216 Patrick, W. M., Nakatani, Y., Cutfield, S. M., Sharpe, M. L., Ramsay, R. J., & Cutfield, J. F. (2010). Carbohydrate binding sites in Candida albicans exo-b-1,3-glucanase and the role of the Phe-Phe ‘clamp’ at the active site entrance. FEBS Journal, 277, 4549-4561. doi: 10.1111/j.1742-4658.2010.07869.x Pearce, S. H. S., & Merriman, T. R. (2009). Genetics of type 1 diabetes and autoimmune thyroid disease. Endocrinology and Metabolism Clinics of North America, 38(2), 289-301. doi: 10.1016/j.ecl.2009.01.012 Pedersen, T. X., McCormick, S. P., Tsimikas, S., Bro, S., & Nielsen, L. B. (2010). Lipoprotein(a) accelerates atherosclerosis in uremic mice. 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Rapid uptake of lipophilic triphenylphosphonium cations by mitochondria in vivo following intravenous injection: Implications for mitochondria-specific therapies and probes. Biochimica et Biophysica Acta, 1800(9), 1009-1017. doi: 10.1016/j.bbagen.2010.06.001 Prime, T. A., Blaikie, F. H., Evans, C., ..., Smith, R. A. J., & Murphy, M. P. (2009). A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury. PNAS, 106(26), 10764-10769. doi: 10.1073/pnas.0903250106 Rae-Whitcombe, S. M., Kennedy, D., Voyles, M., & Thompson, M. P. (2010). Regulation of the promoter region of the human adiponutrin/PNPLA3 gene by glucose and insulin. Biochemical and Biophysical Research Communications, 402(4), 767-772. doi: 10.1016/j.bbrc.2010.10.106 Ramsay, J. P., Sullivan, J. T., Jambari, N., Ortori, C. A., Heeb, S., Williams, P., Barrett, D. A., Lamont, I. L., & Ronson, C. W. (2009). A LuxRI-family regulatory system controls excision and transfer of the Mesorhizobium loti strain R7A symbiosis island by activating expression of two conserved hypothetical genes. Molecular Microbiology, 73(6), 1141-1155. doi: 10.1111/j.1365-2958.2009.06843.x Rautureau, G. J. P., Day, C. L., & Hinds, M. G. (2010). Intrinsically disordered proteins in Bcl-2 regulated apoptosis. International Journal of Molecular Sciences, 11(4), 1808-1824. doi: 10.3390/ijms11041808 Rautureau, G. J. P., Day, C. L., & Hinds, M. G. (2010). The structure of Boo/Diva reveals a divergent Bcl-2 protein. Proteins: Structure Function and Bioinformatics, 78(9), 2181-2186. doi: 10.1002/prot.22728 Reid, D. W., Anderson, G. J., & Lamont, I. L. (2009). Role of lung iron in determining the bacterial and host struggle in cystic fibrosis. American Journal of Physiology: Lung Cellular and Molecular Physiology, 297(5), L795-L802. doi: 10.1152/ ajplung.00132.2009 Rhodes, B., Merriman, M. E., Harrison, A., Nissen, M. J., Smith, M., Stamp, L., Steer, S., Merriman, T. R., & Vyse, T. J. (2010). A genetic association study of serum acute-phase C-reactive protein levels in rheumatoid arthritis: Implications for clinical interpretation. PLoS Medicine, 7(9), e1000341. doi: 10.1371/journal.pmed.1000341 Rhodes, J. M., Bentley, F. K., Print, C. G., Dorsett, D., Misulovin, Z., Dickinson, E. J., Crosier, K. E., Crosier, P. S., & Horsfield, J. A. (2010). Positive regulation of c-Myc by cohesin is direct, and evolutionarily conserved. Developmental Biology, 344, 637-649. doi: 10.1016/j.ydbio.2010.05.493 Risk, J. M., Day, C. L., & Macknight, R. C. (2009). Reevaluation of abscisic acid-binding assays shows that G-Protein-Coupled Receptor2 does not bind abscisic acid. Plant Physiology, 150(1), 6-11. Risk, J. M., Laurie, R. E., Macknight, R. C., & Day, C. L. (2010). FRIGIDA and related proteins have a conserved central domain and family specific N- and C- terminal regions that are functionally important. Plant Molecular Biology, 73, 493-505. doi: 10.1007/s11103-010-9635-2 Roberts, R. L., Topless, R. K. G., Phipps-Green, A. J., Gearry, R. B., Barclay, M. L., & Merriman, T. R. (2010). Evidence of interaction of CARD8 rs2043211 with NALP3 rs35829419 in Crohn’s disease. Genes and Immunity, 11, 351-356. doi: 10.1038/gene.2010.11 Romanel, E. A. C., Schrago, C. G., Couñago, R. M., Russo, C. A. M., & Alves-Ferreira, M. (2009). Evolution of the B3 DNA binding superfamily: New insights into REM family gene diversification. PLoS ONE, 4(6), e5791. doi: 10.1371/journal. pone.0005791 Russell, L. K., Hurd, C. L., Nelson, W. A., & Broom, J. E. (2009). An examination of Pachymenia and Aeodes (Halymeniaceae, Rhodophyta) in New Zealand and the transfer of two species of Aeodes in South Africa to Pachymenia. Journal of Phycology, 45, 1389-1399. doi: 10.1111/j.1529-8817.2009.00761.x Ryan, M. M., Mason-Parker, S. E., Tate, W. P., Abraham, W. C., & Williams, J. M. (2010). Rapidly induced gene networks following induction of long-term potentiation at perforant path synapses in vitro. Hippocampus, Advance Online Publication. doi: 10.1002/hipo.20770 Ryan, M. M., Morris, G., Bourne, K., Mockett, B. G., Abraham, W. C., Tate, W. P., & Williams, J. M. (2009). Regulation of gene expression by sAPPa and RER derivative in differentiated neuroblastoma cells. Alzheimer’s and Dementia, 5(4, Suppl. 1), P421. doi: 10.1016/j.jalz.2009.04.938

130 RESEARCH REPORT 2009/2010 Schalk, I. J., Lamont, I. L., & Cobessi, D. (2009). Structure-function relationships in the bifunctional ferrisiderophore FpvA receptor from Pseudomonas aeruginosa. Biometals, 22(4), 671-678. doi: 10.1007/s10534-008-9203-2 Sharp, C. F., Gardiner, S. J., Jensen, B. P., Roberts, R. L., Troughton, R. W., Lainchbury, J. G., & Begg, E. J. (2009). CYP2D6 genotype and its relationship with metoprolol dose, concentrations and effect in patients with systolic heart failure. Pharmacogenomics Journal, 9(3), 175-184. doi: 10.1038/tpj.2009.9 Shigenobu, S., Bickel, R. D., Brisson, J. A., Butts, T., Chang, C-C., Christiaens, O., Davis, G. K., Duncan, E. J., ..., Smith, J., ..., Wilson, M. J., Dearden, P. K., & Stern, D. L. (2010). Comprehensive survey of developmental genes in the pea aphid, Acyrthosiphon pisum: Frequent lineage-specific duplications and losses of developmental genes. Insect Molecular Biology, 19, 47-62. doi: 10.1111/j.1365-2583.2009.00944.x Shirley, M., & Lamont, I. L. (2009). Role of TonB1 in pyoverdine-mediated signaling in Pseudomonas aeruginosa. Journal of Bacteriology, 191(18), 5634-5640. doi: 10.1128/JB.00742-09 Siakkou, E., Wilbanks, S. M., & Jameson, G. N. L. (2010). Simplified cysteine dioxygenase activity assay allows simultaneous quantitation of both substrate and product. Analytical Biochemistry, 405(1), 127-131. doi: 10.1016/j.ab.2010.06.013 Simms, L. A., Doecke, J. D., Roberts, R. L., ..., Barclay, M. L., Gearry, R. B., Merriman, T. R., Montgomery, G. W., & Radford- Smith, G. L. (2010). KCNN4 gene variant is associated with ileal Crohn’s disease in the Australian and New Zealand population. American Journal of Gastroenterology, Advance Online Publication. doi: 10.1038/ajg.2010.161 Simpson, G. G., Laurie, R. E., Dijkwel, P. P., Quesada, V., Stockwell, P. A., Dean, C., & Macknight, R. C. (2010). Noncanonical translation initiation of the Arabidopsis flowering time and alternative polyadenylation regulator FCA. Plant Cell, 22(11), 3764-3777. doi: 10.1105/tpc.110.077990 Siriwardena, M., Kleffmann, T., Ruygrok, P., Cameron, V. A., Yandle, T. G., Nicholls, M. G., Richards, A. M., & Pemberton, C. J. (2010). B-type natriuretic peptide signal peptide circulates in human blood. Evaluation as a potential biomarker of cardiac ischemia. Circulation, 122, 255-264. doi: 10.1161/CIRCULATIONAHA.109.909937 Smith, J. M., Cridge, A. G., & Dearden, P. K. (2010). Germ cell specification and ovary structure in the rotifer Brachionus plicatilis. EvoDevo, 1, 5. doi: 10.1186/2041-9139-1-5 Smith, K. F., Acosta, H., Broom, J. E., & Rhodes, L. L. (2010). Identification of non-indigenous marine macroalgae from New Zealand aquaria outlets. New Zealand Journal of Marine and Freshwater Research, 44(1), 29-37. doi: 10.1080/00288331003641679 Sowerby, S. J., & Petersen, G. B. (2009). A proposition for single molecule DNA sequencing through a nanopore entropie trap. International Journal of Nanotechnology, 6(3-4), 398-407. doi: 10.1504/IJNT.2009.022928 Specht, D., Wu, S-b., Turner, P., Dearden, P., Koentgen, F., Wolfrum, U., Maw, M., Brandstätter, J. H., & tom Dieck, S. (2009). Effects of presynaptic mutations on a postsynaptic Cacna1s calcium channel colocalized with mGluR6 at mouse photoreceptor ribbon synapses. Investigative Ophthalmology & Visual Science, 50(2), 505-515. doi: 10.1167/iovs.08-2758 Stamp, L. K., Chapman, P. T., O’Donnell, J. L., Zhang, M., James, J., Frampton, C., Barclay, M. L., Kennedy, M. A., & Roberts, R. L. (2010). Polymorphisms within the folate pathway predict folate concentrations but are not associated with disease activity in rheumatoid arthritis patients on methotrexate. Pharmacogenetics and Genomics, 20(6), 367-376. doi: 10.1097/ FPC.0b013e3283398a71 Stuart, E. C., Jarvis, R. M., & Rosengren, R. J. (2010). In vitro mechanism of action for the cytotoxicity elicited by the combination of epigallocatechin gallate and raloxifene in MDA-MB-231 cells. Oncology Reports, 24(3), 779-785. doi: 10.3892/or_00000921 The Australia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene), including Clarke, G., McCallum, R., Merriman, M., Merriman, T., & Mason, D. (2009). Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. Nature Genetics, 41(7), 824-828. doi: 10.1038/ng.396 Thompson, M. P., & Trayhum, P. (2009). Effect of salicylate on the expression of adipokines and glucose transporters in human adipocytes is modulated by hypoxia. Hormone and Metabolic Research, 41(8), 649-652. doi: 10.1055/s-0029- 1214388 Tian, P., & Legge, M. (2010). Cryosolvent interaction with cellular actin using 3T3-LI cells as a model system. Cryobiology, Advance Online Publication. doi: 10.1016/j.cryobiol.2010.09.008 Ting, Y. T., Coates, T. P., Marti, H. P., Dunn, A. C., Parker, R. M., Pickering, J. W., Jack, R. W., Kemp, R. A., Walker, R. J., & McLellan, A. D. (2010). Urinary soluble HLA-DR is a potential biomarker for acute renal transplant rejection. Transplantation, 89(9), 1071-1078. doi: 10.1097/TP.0b013e3181d15492 Trnka, J., Blaikie, F. H., Logan, A., Smith, R. A. J., & Murphy, M. P. (2009). Antioxidant properties of MitoTEMPOL and its hydroxylamine. Free Radical Research, 43(1), 4-12. doi: 10.1080/10715760802582183 Vince, J. E., Pantaki, D., Feltham, R., Mace, P. D., ..., Day, C. L., Vaux, D. L., & Silke, J. (2009). TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (TNF) to efficiently activate NF-kB and to prevent TNF-induced apoptosis. Journal of Biological Chemistry, 284(51), 35906-35915. doi: 10.1074/jbc.M109.072256 Wang, Y-T., von Zychlinski, A., & McCormick, S. P. A. (2009). Dimyristoylphosphotidylcholine induces conformational changes in apoB that lowers lipoprotein(a). Journal of Lipid Research, 50(5), 846-853. doi: 10.1194/jlr.M800428-JLR200 Wan Taib, W. R., Smyth, D. J., Merriman, M. E., Dalbeth, N., Gow, P. J., Harrison, A. A., Highton, J., Jones, P. B. B., Stamp, L., Steer, S., Todd, J. A., & Merriman, T. R. (2010). The PTPN22 locus and rheumatoid arthritis: No evidence for an effect on risk independent of Arg620Trp. PLoS ONE, 5(10), e13544. doi: 10.1371/journal.pone.0013544 Weeks, R. J., Kees, U. R., Song, S., & Morison, I. M. (2010). Silencing of TESTIN by dense biallelic promoter methylation is the most common molecular event in childhood acute lymphoblastic leukaemia. Molecular Cancer, 9, 163. doi: 10.1186/1476- 4598-9-163

Division of HEALTH SCIENCES 131 Weersma, R. K., Crusius, J. B. A., Roberts, R. L., Koeleman, B. P. C., Palomino-Morales, R., Wolfkamp, S., Hollis-Moffatt, J. E., ..., Gearry, R. B., Barclay, M. L., ..., Merriman, T. R., et al. (2010). Association of FcgR2a, but not FcgR3a, with inflammatory bowel diseases across three Caucasian populations. Inflammatory Bowel Diseases, 16(12), 2080-2089. doi: 10.1002/ibd.21342 Westphal, D., Ledgerwood, E. C., Tyndall, J. D. A., Hibma, M. H., Ueda, N., Fleming, S. B., & Mercer, A. A. (2009). The orf virus inhibitor of apoptosis functions in a Bcl-2-like manner, binding and neutralizing a set of BH3-only proteins and active Bax. Apoptosis, 14(11), 1317-1330. doi: 10.1007/s10495-009-0403-1 Wharton, D. A., & Marshall, C. J. (2009). How do terrestrial Antarctic organisms survive in their harsh environment? Journal of Biology, 8, 39. doi: 10.1186/jbiol142 Wharton, D. A., Pow, B., Kristensen, M., Ramløv, H., & Marshall, C. J. (2009). Ice-active proteins and cryoprotectants from the New Zealand alpine cockroach, Celatoblatta quinquemaculata. Journal of Insect Physiology, 55(1), 27-31. doi: 10.1016/j. jinsphys.2008.09.007 Wharton, D. A., Selvanesan, L., & Marshall, C. J. (2010). Ice-active proteins from New Zealand snow tussocks, Chionochloa macra and c. Rigida. CryoLetters, 31(3), 239-248. Wilson, M. J., & Dearden, P. K. (2009). Tailless patterning functions are conserved in the honeybee even in the absence of Torso signaling. Developmental Biology, 335(1), 276-287. doi: 10.1016/j.ydbio.2009.09.002 Wilson, M. J., Havler, M., & Dearden, P. K. (2010). Giant, Krüppel, and caudal act as gap genes with extensive roles in patterning the honeybee embryo. Developmental Biology, 339(1), 200-211. doi: 10.1016/j.ydbio.2009.12.015 Wilson, M. J., McKelvey, B. H., van der Heide, S., & Dearden, P. K. (2010). Notch signaling does not regulate segmentation in the honeybee, Apis mellifera. Development Genes and Evolution, 220(7-8), 179-190. doi: 10.1111/j.1365-2826.2010.02100.x Wu, S. H., Black, M. A., North, R. A., Atkinson, K. R., & Rodrigo, A. G. (2009). A statistical model to identify differentially expressed proteins in 2D PAGE gels. PLoS Computational Biology, 5(9), e1000509. doi: 10.1371/journal.pcbi.1000509 Yeterian, E., Martin, L. W., Guillon, L., Journet, L., Lamont, I. L., & Schalk, I. J. (2010). Synthesis of the siderophore pyoverdine in Pseudomonas aeruginosa involves a periplasmic maturation. Amino Acids, 38(5), 1447-1459. doi: 10.1007/s00726-009- 0358-0 Yeterian, E., Martin, L. W., Lamont, I. L., & Schalk, I. J. (2010). An efflux pump is required for siderophore recycling by Pseudomonas aeruginosa. Environmental Microbiology Reports, 2(3), 412-418. doi: 10.1111/j.1758-2229.2009.00115.x Young, D. J., Edgar, C. D., Murphy, J., Fredebohm, J., Poole, E. S., & Tate, W. (2010). Bioinformatic, structural, and functional analyses support release factor-like MTRF1 as a protein able to decode nonstandard stop codons beginning with adenine in vertebrate mitochondria. RNA, 16(6), 1146-1155. doi: 10.1261/rna.1970310 Young, D. J., Edgar, C. D., Poole, E. S., & Tate, W. P. (2010). The codon specificity of eubacterial release factors is determined by the sequence and size of the recognition loop. RNA, 16, 1623-1633. doi: 10.1261/rna.2117010 Zou, D., Yoon, H-S., Anjomshoaa, A., Perez, D., Fukuzawa, R., Guilford, P., & Humar, B. (2009). Increased levels of active c-Src distinguish invasive from in situ lobular lesions. Breast Cancer Research, 11(4), R45. doi: 10.1186/bcr2332 Zou, D., Yoon, H-S., Perez, D., Weeks, R. J., Guilford, P., & Humar, B. (2009). Epigenetic silencing in non-neoplastic epithelia identifies E-cadherin (CDH1) as a target for chemoprevention of lobular neoplasia. Journal of Pathology, 218(2), 265-272. doi: 10.1002/path.2541

Journal - Research Other Hollis-Moffatt, J. E., Gearry, R. B., Barclay, M. L., Merriman, T. R., & Roberts, R. L. (2010). Consolidation of evidence for association of the KIAA1109-TENR-IL2-IL21 rs6822844 variant with Crohn’s disease [Letter]. American Journal of Gastroenterology, 105(5), 1204-1205. doi: 10.1038/ajg.2010.34 Humar, B., & Guilford, P. (2009). Hereditary diffuse gastric cancer: A manifestation of lost cell polarity. Cancer Science, 100(7), 1151-1157. doi: 10.1111/j.1349-7006.2009.01163.x Jones, G. T., Deng, M., Hammond-Tooke, G. D., McCormick, S. P. A., & van Rij, A. M. (2009). Increased plasma lipoprotein(a) found in large-artery atherosclerotic, but not small-artery occlusive, stroke [Letter to the editor]. Clinical Chemistry, 55(10), 1888-1890. doi: 10.1373/clinchem.2009.126771 Phipps-Green, A. J., Topless, R. K. G., Merriman, M. E., Dalbeth, N., Gow, P. J., Harrison, A. A., Highton, J., Jones, P. B. B., Stamp, L. K., Harrison, P., Wordsworth, B. P., & Merriman, T. R. (2009). No evidence for association of the systemic lupus erythematosus-associated ITGAM variant, R77H, with rheumatoid arthritis in the Caucasian population [Letter to the editor]. Rheumatology, 48(12), 1614-1615. doi: 10.1093/rheumatology/kep254 Roberts, R. L., Gearry, R. B., & Barclay, M. L. (2010). Allopurinol—thiopurine combination therapy in inflammatory bowel disease: Are there genetic clues to this puzzle? [Editorial]. Pharmacogenomics, 11(11), 1505-1508. doi: 10.2217/pgs.10.143 Roberts, R. L., Zhang, M., Marinaki, A. M., & Stamp, L. K. (2010). Does genetic variability in aldehyde oxidase and molybdenum cofactor sulfurase predict nonresponse to allopurinol? [Letter to the editors]. Alimentary Pharmacology & Therapeutics, 32(2), 310-311. doi: 10.1111/j.1365-2036.2010.04349.x Schultz, M., Roberts, R. L., & Butt, A. G. (2010). Understanding probiotic treatment strategies in inflammatory bowel disease, with a special emphasis on the intestinal barrier. European Gastroenterology & Hepatology Review, 6(1), 58-65.

Journal - Professional & Other Non-Research Articles Reid, D. W., O’May, C., Kirov, S. M., Roddam, L., Lamont, I. L., & Sanderson, K. (2009). Iron chelation directed against biofilms as an adjunct to conventional antibiotics [Letter to the editor]. American Journal of Physiology-Lung Cellular and Molecular Physiology, 296(5), L857-L858. doi: 10.1152/ajplung.00058.2009

132 RESEARCH REPORT 2009/2010 Reid, D. W., O’May, C., Roddam, L. F., & Lamont, I. L. (2009). Chelated iron as an anti-Pseudomonas aeruginosa biofilm therapeutic strategy. Journal of Applied Microbiology, 106(3), 1058. doi: 10.1111/j.1365-2672.2008.03955.x Roberts, R. L., Merriman, T. R., & Upton, J. D. (2010). High frequency of MCM6 lactose intolerance genotype in Polynesian People [Letter to the editor]. Alimentary Pharmacology and Therapeutics, 32(6), 828-829. doi: 10.1111/j.1365- 2036.2010.04398.x Wilson, N., Baker, M., Jennings, L., Murdoch, D., Krause, K., Edwards, R., Roberts, M., Pearce, N., Douwes, J., Johnston, D., & Rice, G. (2009). A design fault in New Zealand’s health research funding system exposed by pandemic influenza [Letter]. New Zealand Medical Journal, 122(1304). Retrieved from http://www.nzma.org.nz/journal/122-1304/3839/

Software Stockwell, P. A. (2009). SSEdit: Single (Short) Sequence Editor: For MacOS X. Dunedin, New Zealand: Biochemistry Department, University of Otago.

Data Bank Entry Nakatani, Y. Nalder, T. D., Tannock, G. W., Cutfield, J. F., Jack, R. W. & Carne, A. (2010, July). Crystal structure of a prokaryotic beta-1,3-1,4-glucanase (lichenase) derived from a mouse hindgut metagenome. RCSB Protein Databank entry.

Awarded PhD Thesis Young, D. J. (2009). The recognition of stop codons by the decoding release factors. Dunedin, New Zealand: University of Otago, 235p.

Otago School of Medical Sciences Department of Microbiology and Immunology

Chapter in Book - Research Cook, G. M., Berney, M., Gebhard, S., Heinemann, M., Cox, R. A., Danilchanka, O., & Niederweis, M. (2009). Physiology of mycobacteria. In R. K. Poole (Ed.), Advances in microbial physiology (Vol. 55) (pp. 83-183). London: Elsevier. doi: 10.1016/ s0065-2911(09)05502-7 Fineran, P. C., Petty, N. K., & Salmond, G. P. C. (2009). Transduction: Host DNA transfer by bacteriophages. In M. Schaechter (Ed.), Encyclopedia of microbiology (Vol. 3) (3rd ed.). (pp. 666-679). Oxford, UK: Elsevier. Gopal, P., & Tannock, G. W. (2010). Single and multiple probiotic organisms in therapy of disease. In M. H. Floch & A. S. Kim (Eds.), Probiotics: A clinical guide (pp. 121-130). Thorofare, NJ: SLACK. Stoitzner, P., Romani, N., McLellan, A. D., Tripp, C. H., & Ebner, S. (2010). Isolation of skin dentritic cells from mouse and man. In S. H. Naik (Ed.), Dendritic cell protocols: Methods in Molecular Biology (Vol. 595) (2nd ed.). (pp. 235-248). Totowa, NJ: Humana Press. doi: 10.1007/978-1-60761-421-0_16 Tannock, G. W. (2009). Microbial succession and gut health: Probiotics. In L-A. Jaykus, H. H. Wang & L. S. Schlesinger (Eds.), Food-borne microbes: Shaping the host ecosystem (pp. 63-80). Washington, DC: ASM Press. Tannock, G. W. (2009). The microbiota of humans. In B. Henderson, M. A. Curtis, R. M. Seymour & N. Donos (Eds.), Periodontal medicine and systems biology (pp. 129-138). Chichester, UK: Blackwell. Tannock, G. W. (2009). What pediatricians need to know about the analysis of the gut microbiota. In S. Michail & P. M. Sherman (Eds.), Probiotics in pediatric medicine (pp. 17-28). Totowa, NJ: Human Press. doi: 10.1007/978-1-60327-289-6 Tannock, G. W. (2010). Analysis of bifidobacterial populations in bowel ecology studies. In B. Mayo & D. van Sinderen (Eds.), Bifidobacteria: Genomics and molecular aspects (pp. 1-16). Norfolk, UK: Caister Academic Press. Ward, V. K., Cooke, B. D., & Strive, T. (2010). Rabbit haemorrhagic disease virus and other lagoviruses. In G. S. Hansman, X. J. Jiang, & K. Y. Green (Eds.), Caliciviruses: Molecular and Cellular Virology (pp. 223-246). Norfolk, UK: Caister Academic Press. Williams, T., & Ward, V. K. (2010). Iridoviruses. In S. Asgari & K. N. Johnson (Eds.), Insect virology (pp. 123-151). Norfolk, UK: Caister Academic.

Journal - Research Article Al-Mahrous, M., Sandiford, S. K., Tagg, J. R., & Upton, M. (2010). Purification and characterization of a novel delta-lysin variant that inhibits Staphylococcus aureus and has limited hemolytic activity. Peptides, 31(9), 1661-1668. doi: 10.1016/j. peptides.2010.06.006 Berney, M., & Cook, G. M. (2010). Unique flexibility in energy metabolism allows mycobacteria to combat starvation and hypoxia. PLoS ONE, 5(1), e8614. doi: 10.1371/journal.pone.0008614 Blower, T. R., Fineran, P. C., Johnson, M. J., Toth, I. K., Humphreys, D. P., & Salmond, G. P. C. (2009). Mutagenesis and functional characterization of the RNA and protein components of the toxIN abortive infection and toxin-antitoxin locus of Erwinia. Journal of Bacteriology, 191(19), 6029-6039. doi: 10.1128/JB.00720-09 Bouwer, A. L., Netter, P., Kemp, R. A., & McLellan, A. D. (2010). A defined serum-free medium useful for monitoring anti- melanoma responses induced by dendritic cell immunotherapy. Journal of Immunological Methods, 352, 178-181. doi: 10.1016/j.jim.2009.11.001

Division of HEALTH SCIENCES 133 Bowden, T., Coupar, B. E., Babiuk, S. L., ..., Ueda, N., et al. (2009). Detection of antibodies specific for sheeppox and goatpox viruses using recombinant capripoxvirus antigens in an indirect enzyme-linked immunosorbent assay. Journal of Virological Methods, 161(1), 19-29. doi: 10.1016/j.jviromet.2009.04.031 Buchan, G. S., Lee, R., Wilson, M., Slobbe, L., Buddle, B. M., & Young, S. L. (2010). Strains of Mycobacterium avium differentially activate human dendritic cells. Immunology and Cell Biology, 88(1), 95-98. doi: 10.1038/icb.2009.51 Buddle, B. M., Wilson, T., Denis, M., Greenwald, R., Esfandiari, J., Lyashchenko, K. P., Liggett, S., & Mackintosh, C. G. (2010). Sensitivity, specificity and confounding factors of novel serological tests used for the rapid diagnosis of bovine tuberculosis in farmed red deer (Cervus elaphus). Clinical and Vaccine Immunology, 17(4), 626-630. doi: 10.1128/CVI.00010-10 Burton, J. P., Chilcott, C. N., Wescombe, P. A., & Tagg, J. R. (2010). Extended safety data for the oral cavity probiotic Streptococcus salivarius K12. Probiotics and Antimicrobial Proteins, 2(3), 135-144. doi: 10.1007/s12602-010-9045-4 Carter, P. E., McTavish, S. M., Brooks, H. J. L., Campbell, D., Collins-Emerson, J. M., Midwinter, A. C., & French, N. P. (2009). Novel clonal complexes with an unknown animal reservoir dominate Campylobacter jejuni isolates from river water in New Zealand. Applied and Environmental Microbiology, 75(19), 6038-6046. doi: 10.1128/aem.01039-09 Chang, S-J., Hsiao, J-C., Sonnberg, S., Chiang, C-T., Yang, M-H., Tzou, D-L., Mercer, A. A., & Chang, W. (2009). Poxvirus host range protein CP77 contains an F-box-like domain that is necessary to suppress NF-kB activation by tumor necrosis factor alpha but is independent of its host range function. Journal of Virology, 83(9), 4140-4152. doi: 10.1128/jvi.01835-08 Clark, R. G., Griffin, J. F. T., & Mackintosh, C. G. (2010). Johne’s disease caused by Mycobacterium avium subsp. paratuberculusis infection in red deer (Cervus elaphus): An histopathologidal grading system, and comparison of paucibacillary and multibacillary disease. New Zealand Veterinary Journal, 58(2), 90-97. Coulibaly, F., Chiu, E., Gutmann, S., ..., Ward, V. K., et al. (2009). The atomic structure of baculovirus polyhedra reveals the independent emergence of infectious crystals in DNA and RNA viruses. PNAS, 106(52), 22205-22210. doi: 10.1073/ pnas.0910686106 Couñago, R. M., Fleming, S. B., Mercer, A. A., & Krause, K. L. (2010). Crystallization and preliminary X-ray analysis of the chemokine-binding protein from orf virus (Poxviridae). Acta Crystallographica, F66, 819-823. doi: 10.1107/ S1744309110018166 Daly, K. M., Upton, M., Sandiford, S. K., ..., Jack, R. W., Tagg, J. R., et al. (2010). Production of the Bsa lantibiotic by community-acquired Staphylococcus aureus strains. Journal of Bacteriology, 192(4), 1131-1142. doi: 10.1128/JB.01375-09 Deane, D., Ueda, N., Wise, L. M., Wood, A. R., Percival, A., Jepson, C., Inglis, N. F., Fleming, S. B., Mercer, A. A., & McInnes, C. J. (2009). Conservation and variation of the parapoxvirus GM-CSF-inhibitory factor (GIF) proteins. Journal of General Virology, 90, 970-977. doi: 10.1099/vir.0.006692-0 Dekker, J. W., Wickens, K., Black, P. C., Stanley, T. V., Mitchell, E. A., Fitzharris, P., Tannock, G. W., Purdie, G., & Crane, J. (2009). Safety aspects of probiotic bacterial strains Lactobacillus rhamnosus HN001 and Bifidobacterium animalis subsp. lactis HN019 in human infants aged 0-2 years. International Dairy Journal, 19(3), 149-154. doi: 10.1016/j. idairyj.2008.10.004 Dobson, B. J., Mackintosh, C. G., & Griffin, J. F. T. (2010). Development of the thymus and Peyer’s patches in the first year of life in red deer (Cervus elaphus). Veterinary Immunology and Immunopathology, 137, 93-98. doi: 10.1016/j. vetimm.2010.04.014 Erickson, A. H. L., Wise, A., Fleming, S., Baird, M., Lateef, Z., Molinaro, A., Teboh-Ewungkem, M., & de Pillis, L. (2009). A preliminary mathematical model of skin dendritic cell trafficking and induction of T cell imunity. Discrete and Continuous Dynamical Systems: Series B, 12(2), 323-336. doi: 10.3934/dcdsb.2009.12.323 Fineran, P. C., Blower, T. R., Foulds, I. J., Humphreys, D. P., Lilley, K. S., & Salmond, G. P. C. (2009). The phage abortive infection system, toxIN, functions as a protein-RNA toxin-antitoxin pair. PNAS, 106(3), 894-899. doi: 10.1073/ pnas.0808832106 Gargis, A. S., O’Rourke, A-L. D., Sloan, G. L., & Simmonds, R. S. (2009). Prevalence and acquisition of the genes for zoocin A and zoocin A resistance in Streptococcus equi subsp. zooepidemicus. Journal of Molecular Evolution, 68(5), 498-505. doi: 10.1007/s00239-009-9221-x Gargis, S. R., Gargis, A. S., Heath, H. E., Heath, L. S., LeBlanc, P. A., Senn, M. M., Berger-Bächi, B., Simmonds, R. S., & Sloan, G. L. (2009). Zif, the zoocin A immunity factor, is a FemABX-like immunity protein with a novel mode of action. Applied and Environmental Microbiology, 75(19), 6205-6210. doi: 10.1128/aem.01011-09 Gargis, S. R., Heath, H. E., Heath, L. S., LeBlanc, P. A., Simmonds, R. S., Abbott, B. N., Timkovich, R., & Sloan, G. L. (2009). Use of 4-sulfophenyl isothiocyanate labeling and mass spectrometry to determine the site of action of the streptococcolytic peptidoglycan hydrolase zoocin A. Applied and Environmental Microbiology, 75(1), 72-77. doi: 10.1128/AEM.01647-08 Gargis, S. R., Heath, H. E., LeBlanc, P. A., Dekker, L., Simmonds, R. S., & Sloan, G. L. (2010). Inhibition of the activity of both domains of lysostaphin through peptidoglycan modification by the lysostaphin immunity protein. Applied and Environmental Microbiology, 76(20), 6944-6946. doi: 10.1128/AEM.01066-10 Gargis, S. R., Heath, H. E., LeBlanc, P. A., Dekker, L., Simmonds, R. S., & Sloan, G. L. (2010). Inhibition of the activity of both domains of lysostaphin through peptidoglycan modification by the lysostaphin immunity protein. Applied and Environmental Microbiology, 76(20), 6944-6946. doi: 10.1128/AEM.01066-10 Gatehouse, H. S., Poulton, J., Markwick, N. P., Gatehouse, L. N., Ward, V. K., Young, V. L., Luo, Z., Schaffer, R., & Christeller, J. T. (2009). Changes in gene expression in the permissive larval host lightbrown apple moth (Epiphyas postvittana, Tortricidae) in response to EppoNPV (Baculoviridae) infection. Insect Molecular Biology, 18(5), 635-648. doi: 10.1111/j.1365-2583.2009.00904.x

134 RESEARCH REPORT 2009/2010 Gavicherla, B., Ritchey, L., Gianfelice, A., Kolokoltsov, A. A., Davey, R. A., & Ireton, K. (2010). Critical role for the host GTPase- activating protein ARAP2 in InIB-mediated entry of Listeria monocytogenes. Infection and Immunity, 78(11), 4532-4541. doi: 10.1128/IAI.00802-10 Gebhard, S., Ekanayaka, N., & Cook, G. M. (2009). The low-affinity phosphate transporter PitA is dispensable for in vitro growth of Mycobacterium smegmatis. Respiratory Research, 10. doi: 10.1186/1471-2180-9-254 Gebhard, S., Gaballa, A., Helmann, J. D., & Cook, G. M. (2009). Direct stimulus perception and transcription activation by a membrane-bound DNA binding protein. Molecular Microbiology, 73(3), 482-491. doi: 10.1111/j.1365-2958.2009.06787.x Gillan, S., Hughes, A. D., O’Brien, R., & Griffin, J. F. T. (2010). Ovine immune parameters following immunisation against Mycobacterium avium ssp. paratuberculosis using a lipid-based live cell vaccine. Veterinary Immunology and Immunopathology, 137(1-2), 109-119. doi: 10.1016/j.vetimm.2010.04.020 Gillan, S., O’Brien, R., Hughes, A. D., & Griffin, J. F. T. (2010). Identification of immune parameters to differentiate disease states among sheep infected with Mycobacterium avium subsp paratuberculosis. Clinical and Vaccine Immunology, 17(1), 108-117. doi: 10.1128/CVI.00359-09 Gordon, S., Teichmann, E., Young, K., Finnie, K., Rades, T., & Hook, S. (2010). In vitro and in vivo investigation of thermosensitive chitosan hydrogels containing silica nanoparticles for vaccine delivery. European Journal of Pharmaceutical Sciences, Advance Online Publication. doi: 10.1016/j.ejps.2010.07.004 Griffin, J. F. T., Hughes, A. D., Liggett, S., Farquhar, P. A., Mackintosh, C. G., & Bakker, D. (2009). Efficacy of novel lipid- formulated whole bacterial cell vaccines against Mycobacterium avium subsp. paratuberculosis in sheep. Vaccine, 27(6), 911-918. doi: 10.1016/j.vaccine.2008.11.053 Gristwood, T., Fineran, P. C., Everson, L., Williamson, N. R., & Salmond, G. P. (2009). The PhoBR two-component system regulates antibiotic biosynthesis in Serratia in response to phosphate. BMC Microbiology, 9, 112. doi: 10.1186/1471-2180- 9-112 Gristwood, T., McNeil, M., Clulow, J., Salmond, G. P. C., & Fineran, P. C. (2010). PigS and PigP regulate prodigiosin biosynthesis in Serratia via differential control of divergent operons, which include predicted transporters of sulfur- containing molecules. Journal of Bacteriology, Advance Online Publication. doi: 10.1128/JB.00352-10 Hautaniemi, M., Ueda, N., Tuimala, J., Mercer, A. A., Lahdenperä, J., & McInnes, C. J. (2010). The genome of pseudocowpoxvirus: Comparison of a reindeer isolate and a reference strain. Journal of General Virology, 91(6), 1560-1576. doi: 10.1099/vir.0.018374-0 Hibma, M. H., Real, N. C., Wiles, A., Dobson-Le, D., Dix, B. R., Wynford-Thomas, D., Braithwaite, A. W., & Royds, J. A. (2009). Increased apoptosis and reduced replication efficiency of the E3 region-modified dl309 adenovirus in cancer cells. Virus Research, 145(1), 112-120. doi: 10.1016/j.virusres.2009.06.016 Hümpel, A., Gebhard, S., Cook, G. M., & Berney, M. (2010). The SigF regulon in Mycobacterium smegmatis reveals roles in adaptation to stationary phase, heat and oxidative stress. Journal of Bacteriology, 192(10), 2491-2502. doi: 10.1128/ JB.00035-10 Ireton, K. (2010). Anthrax toxins: Roadblocks for exocytic trafficking. Developmental Cell, 19(5), 643-644. doi: 10.1016/j. devcel.2010.10.019 Jeffs, A. R., Glover, A. C., Slobbe, L. J., Wang, L., He, S., Hazlett, J. A., Awasthi, A., Woolley, A. G., Marshall, E. S., Joseph, W. R., Print, C. G., Baguley, B. C., & Eccles, M. R. (2009). A gene expression signature of invasive potential in metastatic melanoma cells. PLoS ONE, 4(12), e8461. doi: 10.1371/journal.pone.0008461 Jenks, K., Stebbings, S., Burton, J., Schultz, M., Herbison, G. P., & Highton, J. (2010). Probiotic therapy for the treatment of spondyloarthritis: A randomized controlled trial. Journal of Rheumatology, Advance Online Publication. doi: 10.3899/ jrheum.100193 Jones, R. J., Wiklund, E., Zagorec, M., & Tagg, J. R. (2010). Evaluation of stored lamb bio-preserved using a three-strain cocktail of Lactobacillus sakei. Meat Science, Advance Online Publication. doi: 10.1016/j.meatsci.2010.07.023 Jones, R. J., Zagorec, M., Brightwell, G., & Tagg, J. R. (2009). Inhibition by Lactobacillus sakei of other species in the flora of vacuum packaged raw meats during prolonged storage. Food Microbiology, 26(8), 876-881. doi: 10.1016/j.fm.2009.06.003 Katpally, U., Voss, N. R., Cavazza, T., Taube, S., Rubin, J. R., Young, V. L., Stuckey, J., Ward, V. K., et al. (2010). High-resolution cryo-electron microscopy structures of murine norovirus 1 and rabbit hemorrhagic disease virus reveal marked flexibility in the receptor binding domains. Journal of Virology, 84(11), 5836-5841. doi: 10.1128/JVI.00314-10 Kemp, R. A., Pearson, C. F., Cornish, G. H., & Seddon, B. P. (2010). Evidence of STAT5-dependent and -independent routes to CD8 memory formation and a preferential role for IL-7 over IL-15 in STAT5 activation. Immunology and Cell Biology, 88, 213-219. doi: 10.1038/icb.2009.95 Lateef, Z., Baird, M. A., Wise, L. M., Mercer, A. A., & Fleming, S. B. (2009). Orf virus-encoded chemokine-binding protein is a potent inhibitor of inflammatory monocyte recruitment in a mouse skin model. Journal of General Virology, 90(6), 1477- 1482. doi: 10.1099/vir.0.009589-0 Lateef, Z., Baird, M. A., Wise, L. M., Young, S., Mercer, A. A., & Fleming, S. B. (2010). The chemokine binding protein encoded by the poxvirus orf virus inhibits recruitment of dendritic cells to sites of skin inflammation and migration to peripheral lymph nodes. Cellular Microbiology, 12(5), 665-676. doi: 10.1111/j.1462-5822.2009.01425.x Lee, H. J., Orlovich, D. A., Tagg, J. R., & Fawcett, J. P. (2009). Detection and specific enumeration of multi-strain probiotics in the lumen contents and mucus layers of the rat intestine after oral administration. Probiotics and Antimicrobial Proteins, 1(2), 113-120. doi: 10.1007/s12602-009-9019-6 Leong, C-M. (Jimmy), Doorbar, J., Nindl, I., Yoon, H-S., & Hibma, M. H. (2010). Deregulation of E-cadherin by human papillomavirus is not confined to high-risk, cancer-causing types. British Journal of Dermatology, 163(6), 1253-1263. doi: 10.1111/j.1365-2133.2010.09968.x

Division of HEALTH SCIENCES 135 Leong, C-M. (Jimmy), Doorbar, J., Nindl, I., Yoon, H-S., & Hibma, M. H. (2010). Loss of epidermal Langerhans cells occurs in human papillomavirus a, g, and m but not b genus infections. Journal of Investigative Dermatology, 130(2), 472-480. doi: 10.1038/jid.2009.266 Lim, K. H., Brooks, H., McDougal, R., Burton, J., Devenish, C., & De Silva, T. (2010). Is there a correlation between bacterial vaginosis and preterm labour in women in the Otago region of New Zealand? Australian and New Zealand Journal of Obstetrics and Gynaecology, 50(3), 226-229. doi: 10.1111/j.1479-828X.2010.01149.x Livingston, M., Loach, D., Wilson, M., Tannock, G. W., & Baird, M. (2010). Gut commensal Lactobacillus reuteri 100-23 stimulates an immunoregulatory response. Immunology and Cell Biology, 88(1), 99-102. doi: 10.1038/icb.2009.71 Maas, E. W., & Brooks, H. J. L. (2010). Is photosynthesis a requirement for paralytic shellfish toxin production in the dinoflagellate Alexandrium minutum algal-bacterial consortium. Journal of Applied Phycology, 22, 293-296. doi: 10.1007/ s10811-009-9458-1 Mackintosh, C. G., Clark, R. G., Thompson, B., Tolentino, B., Griffin, F. F. T., & de Lisle, G. W. (2010). Age susceptibility of red deer (Cervus elaphus) to paratuberculosis. Veterinary Microbiology, 143(2-4), 255-261. doi: 10.1016/j.vetmic.2009.11.014 Madsen, L. H., Tirichine, L., Jurkiewicz, A., Sullivan, J. T., ..., Ronson, C. W., et al. (2010). The molecular network governing nodule organogenesis and infection in the model legume Lotus japonicus. Nature Communications, 1. doi: 10.1038/ ncomms1009 Markwick, N. P., Glare, T. R., Hauxwell, C., Li, Z., Poulton, J., Ward, J. M., Young, V. L., & Ward, V. K. (2010). The infectivity and host range of Orgyia anartoides nucleopolyhedrovirus. Journal of Applied Entomology, 134(1), 61-71. doi: 10.1111/j.1439-0418.2009.01443.x

Matthies, D., Preiss, L., Klyszejko, A. L., Muller, D. J., Cook, G. M., Vonck, J., & Meier, T. (2009). The c13 ring from a thermoalkaliphilic ATP synthase reveals an extended diameter due to a special structural region. Journal of Molecular Biology, 388(3), 611-618. doi: 10.1016/j.jmb.2009.03.052 McMillan, D. G. G., Keis, S., Berney, M., & Cook, G. M. (2009). Nonfermentative thermoalkaliphilic growth is restricted to alkaline environments. Applied and Environmental Microbiology, 75(24), 7649-7654. doi: 10.1128/AEM.01639-09 McMillan, D. G. G., Velasquez, I., Nunn, B. L., Goodlett, D. R., Hunter, K. A., Lamont, I., Sander, S. G., & Cook, G. M. (2010). Acquisition of iron by alkaliphilic Bacillus species. Applied and Environmental Microbiology, 76(20), 6955-6961. doi: 10.1128/AEM.01393-10 Mesbah, N. M., Cook, G. M., & Wiegel, J. (2009). The halophilic alkalithermophile Natranaerobius thermophilus adapts to multiple environmental extremes using a large repertoire of Na+(K+)/H+ antiporters. Molecular Microbiology, 74(2), 270- 281. doi: 10.1111/j.1365-2958.2009.06845.x Mo, M., Fleming, S. B., & Mercer, A. A. (2009). Cell cycle deregulation by a poxvirus partial mimic of anaphase-promoting complex subunit 11. PNAS, 106(46), 19527-19532. doi: 10.1073/pnas.0905893106 Mo, M., Fleming, S. B., & Mercer, A. A. (2010). Orf virus cell cycle regulator, PACR, competes with subunit 11 of the anaphase promoting complex for incorporation into the complex. Journal of General Virology, 91, 3010-3015. doi: 10.1099/ vir.0.026054-0 Moran, J. P., Walter, J., Tannock, G. W., Tonkonogy, S. L., & Sartor, R. B. (2009). Bifidobacterium animalis causes extensive duodenitis and mild colonic inflammation in monoassociated interleukin-10-deficient mice. Inflammatory Bowel Diseases, 15(7), 1022-1031. doi: 10.1002/ibd.20900 Noisangiam, R., Nuntagij, A., Pongsilp, N., Boonkerd, N., Denduangboripant, J., Ronson, C., & Teaumroong, N. (2010). Heavy metal tolerant Metalliresistens boonkerdii gen. nov., sp. nov., a new genus in the family Bradyrhizobiaceae isolated from soil in Thailand. Systematic and Applied Microbiology, Advance Online Publication. doi: 10.1016/j.syapm.2010.06.002 Ott, T., Sullivan, J., James, E. K., Flemetakis, E., Günther, C., Gibon, Y., Ronson, C., & Udvardi, M. (2009). Absence of symbiotic leghemoglobins alters bacteroid and plant cell differentiation during development of Lotus japonicus root nodules. Molecular Plant-Microbe Interactions, 22(7), 800-808. doi: 10.1094/MPMI-22-7-0800 Pieterse, M. C., Eisenberg, S. W., Folmer, G. E., Liggett, S., Griffin, J. F., et al. (2010). Evidence of Mycobacterium avium subsp. Paratuberculosis infection in Dutch farmed red deer. Tijdschrift Voor Diergeneeskunde, 135(23), 886-890. Ramsay, J. P., Sullivan, J. T., Jambari, N., Ortori, C. A., Heeb, S., Williams, P., Barrett, D. A., Lamont, I. L., & Ronson, C. W. (2009). A LuxRI-family regulatory system controls excision and transfer of the Mesorhizobium loti strain R7A symbiosis island by activating expression of two conserved hypothetical genes. Molecular Microbiology, 73(6), 1141-1155. doi: 10.1111/j.1365-2958.2009.06843.x Robinson, M. W., O’Brien, R., Mackintosh, C. G., & Griffin, J. F. T. (2010). Peripheral blood mononuclear cell population changes associated with age and Mycobacterium avium subspecies paratuberculosis infection in red deer (Cervus elaphus). Veterinary Immunology and Immunopathology, 136(3-4), 211-218. doi: 10.1016/j.vetimm.2010.03.009 Robson, J., McKenzie, J. L., Cursons, R., Cook, G. M., & Arcus, V. L. (2009). The vapBC operon from Mycobacterium smegmatis is an autoregulated toxin-antitoxin module that controls growth via inhibition of translation. Journal of Molecular Biology, 390, 353-367. doi: 10.1016/j.jmb.2009.05.006 Rodpothong, P., Sullivan, J. T., Songsrirote, K., Sumpton, D., Cheung, K. W. J-T., Thomas-Oates, J., Radutoiu, S., Stougaard, J., & Ronson, C. W. (2009). Nodulation gene mutants of Mesorhizobium loti R7A—nodZ and nolL mutants have host-specific phenotypes on Lotus spp. Molecular Plant-Microbe Interactions, 22(12), 1546-1554. doi: 10.1094/MPMI-22-12-1546 Rose, S. B., Lawton, B. A., Lanumata, T., Hibma, M., & Baker, M. G. (2010). HPV/cervical cancer vaccination: Parental preferences on age, place and information needs. Journal of Primary Health Care, 2(3), 190-198. Shepherd, M., Sanguinetti, G., Cook, G. M., & Poole, R. K. (2010). Compensations for diminished terminal oxidase activity in Escherichia coli: Cytochrome bd-II-mediated respiration and glutamate metabolism. Journal of Biological Chemistry, 285(24), 18464-18472. doi: 10.1074/jbc.M110.118448

136 RESEARCH REPORT 2009/2010 Slatter, T. L., Ganesan, P., Holzhauer, C., Mehta, R., Rubio, C., Williams, G., Wilson, M., Royds, J. A., Baird, M. A., & Braithwaite, A. W. (2010). p53-mediated apoptosis prevents the accumulation of progenitor B cells and B-cell tumors. Cell Death and Differentiation, 17, 540-550. doi: 10.1038/cdd.2009.136 Sonnberg, S., Fleming, S. B., & Mercer, A. A. (2009). A truncated two-a-helix F-box present in poxvirus ankyrin-repeat proteins is sufficient for binding the SCF1 ubiquitin ligase complex. Journal of General Virology, 90, 1224-1228. doi: 10.1099/vir.0.009324-0 Stebbings, S. M., Taylor, C., Tannock, G. W., Baird, A. A., & Highton, J. (2009). The immune response to autologous bacteroides in ankylosing spondylitis is characterized by reduced interleukin 10 production. Journal of Rheumatology, 36(4), 797-800. doi: 10.3899/jrheum.080964 Swe, P. M., Cook, G. M., Tagg, J. R., & Jack, R. W. (2009). Mode of action of dysgalacticin: A large heat-labile bacteriocin. Journal of Antimicrobial Chemotherapy, 63(4), 679-686. doi: 10.1093/jac/dkn552 Swe, P. M., Heng, N. C. K., Cook, G. M., Tagg, J. R., & Jack, R. W. (2010). Identification of Dysl, the immunity factor of the streptococcal bacteriocin dysgalacticin. Applied and Environmental Microbiology, 76(23), 7885-7889. doi: 10.1128/ AEM.01707-10 Tagg, J. R. (2009). Streptococcal bacteriocin-like inhibitory substances: Some personal insights into the bacteriocin-like activities produced by streptococci good and bad. Probiotics and Antimicrobial Proteins, 1(1), 60-66. doi: 10.1007/s12602- 008-9002-7 Tan, J. L., Ueda, N., Mercer, A. A., & Fleming, S. B. (2009). Investigation of orf virus structure and morphogenesis using recombinants expressing FLAG-tagged envelope structural proteins: Evidence for wrapped virus particles and egress from infected cells. Journal of General Virology, 90(3), 614-625. doi: 10.1099/vir.0.005488-0 Tannock, G., Munro, K., Taylor, C., Lawley, B., Young, W., Byrne, B., Emery, J., & Louie, T. (2010). A new macrocyclic antibiotic, Fidaxomicin (OPT-80), causes less alteration to the bowel microbiota of Clostridium difficile-infected patients than does vancomycin. Microbiology, Advance Online Publication. doi: 10.1099/mic.0.042010-0 Tannock, G. W. (2010). The bowel microbiota and inflammatory bowel diseases. International Journal of Inflammation, 954051. doi: 10.4061/2010/954051 Tannock, G. W., Tiong, I. S., Priest, P., Munro, K., Taylor, C., & Schultz, M. (2010). Testing probiotic strain Escherichia coli Nissle 1917 (MutaflorÒ) for ability to reduce carriage of multi-drug resistant E. coli by elderly residents of long term care facilities. Journal of Medical Microbiology, Advance Online Publication. doi: 10.1099/jmm.0.025874-0 Taylor, M., Navarro-Garcia, F., Huerta, J., ..., Ireton, K., et al. (2010). Hsp90 is required for transfer of the cholera toxin A1 subunit from the endoplasmic reticulum to the cytosol. Journal of Biological Chemistry, 285(41), 31261-31267. doi: 10.1074/jbc.M110.148981 Temme, S., Eis-Hübinger, A. M., McLellan, A. D., & Koch, N. (2010). The herpes simplex virus-1 encoded glycoprotein B diverts HLA-DR into the exosome pathway. Journal of Immunology, 184(1), 236-243. doi: 10.4049/jimmunol.0902192 Thanawastien, A., Montor, W. R., LaBaer, J., Mekalanos, J. J., & Yoon, S. S. (2009). Vibrio cholerae proteome-wide screen for immunostimulatory proteins identifies phosphatidylserine decarboxylase as a novel toll-like receptor 4 agonist. PLoS Pathogens, 5(8), e1000556. doi: 10.1371/journal.ppat.1000556 Ting, Y. T., Coates, T. P., Marti, H. P., Dunn, A. C., Parker, R. M., Pickering, J. W., Jack, R. W., Kemp, R. A., Walker, R. J., & McLellan, A. D. (2010). Urinary soluble HLA-DR is a potential biomarker for acute renal transplant rejection. Transplantation, 89(9), 1071-1078. doi: 10.1097/TP.0b013e3181d15492 Ting, Y. T., Temme, S., Koch, N., & McLellan, A. D. (2009). A new monoclonal antibody recognizing a linear determinant on the HLA-DRa chain N-terminus. Hybridoma, 28(6), 423-429. doi: 10.1089/hyb.2009.0050 Wescombe, P. A., Heng, N. C. K., Burton, J. P., Chilcott, C. N., & Tagg, J. R. (2009). Streptococcal bacteriocins and the case for Streptococcus salivarius as model oral probiotics. Future Microbiology, 4(7), 819-835. doi: 10.2217/fmb.09.61 Wescombe, P. A., Heng, N. C. K., Burton, J. P., & Tagg, J. R. (2010). Something old and something new: An update on the amazing repertoire of bacteriocins produced by Streptococcus salivarius. Probiotics and Antimicrobial Proteins, 2(1), 37-45. doi: 10.1007/s12602-009-9026-7 Westphal, D., Ledgerwood, E. C., Tyndall, J. D. A., Hibma, M. H., Ueda, N., Fleming, S. B., & Mercer, A. A. (2009). The orf virus inhibitor of apoptosis functions in a Bcl-2-like manner, binding and neutralizing a set of BH3-only proteins and active Bax. Apoptosis, 14(11), 1317-1330. doi: 10.1007/s10495-009-0403-1 Wolf, D., Kalamorz, F., Wecke, T., Juszczak, A., Mäder, U., et al. (2010). In-depth profiling of the LiaR response of Bacillus subtilis. Journal of Bacteriology, 192(18), 4680-4693. doi: 10.1128/JB.00543-10 Young, S. L., Slobbe, L. J., Peacey, M., Gilbert, S. C., Buddle, B. M., de Lisle, G. W., & Buchan, G. S. (2010). Immunogenicity and protective efficacy of mycobacterial DNA vaccines incorporating plasmid-encoded cytokines against Mycobacterium bovis. Immunology & Cell Biology, 88(6), 651-657. doi: 10.1038/icb.2010.25 Young, V. L., Sneddon, K. M. B., & Ward, V. K. (2010). Establishment of a neonate cell line from Epiphyas postvittana (Walker) (Lepidoptera: Tortricidae) that supports replication of E. postvittana nucleopolyhedrovirus. Journal of Invertebrate Pathology, 104, 147-149. doi: 10.1016/j.jip.2010.02.004 Zeddam, J-L., Gordon, K. H. J., Lauber, C., Felipe Alves, C. A., Luke, B. T., Hanzlik, T. N., Ward, V. K., & Gorbalenya, A. E. (2010). Euprosterna elaeasa virus genome sequence and evolution of the Tetraviridae family: Emergence of bipartite genomes and conservation of the VPg signal with the dsRNA Birnaviridae family. Virology, 397(1), 145-154. doi: 10.1016/j. virol.2009.10.042

Division of HEALTH SCIENCES 137 Journal - Research Other McLellan, A. D. (2009). Exosome release by primary B cells. Critical Reviews in Immunology, 29(3), 203-217. McLellan, A. D. (2009). Monoclonal antibody 1C4.6 against the HLA DRa N-terminus. Hybridoma, 28(6), 468. doi: 10.1089/ hyb.2009.0062.MAb Mo, M., Fleming, S. B., & Mercer, A. A. (2010). Changing pace: Viral mimicry of an anaphase promoting complex subunit [Editorial]. Cell Cycle, 9(4), 632-633.

Data Bank Entry Nakatani, Y. Nalder, T. D., Tannock, G. W., Cutfield, J. F., Jack, R. W. & Carne, A. (2010, July). Crystal structure of a prokaryotic beta-1,3-1,4-glucanase (lichenase) derived from a mouse hindgut metagenome. RCSB Protein Databank entry.

Otago School of Medical Sciences Department of Pharmacology and Toxicology

Chapter in Book - Research Darlington, C. L., Zheng, Y., & Smith, P. F. (2009). Herbal medicinal products for tinnitus: Perspectives and evaluation. In P. Houghton & P. K. Mukherjee (Eds.), Evaluation of herbal medicinal products (pp. 314-321). London: Pharmaceutical Press. Giles, G. I. (2009). Redox-controlled transcription factors and gene expression. In C. Jacob & P. G. Winyard (Eds.), Redox signaling and regulation in biology and medicine (pp. 245-270). Weinheim, Germany: Wiley-VCH. Kerr, D. S. (2009). Domoic acid neurotoxicity. In M. D. Biner, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience (pp. 990-995). Berlin, Germany: Springer. Rosengren, R. J. (2009). Utility of epigallocatechin gallate in the treatment and prevention of breast cancer: Molecular mechanisms for tumor suppression. In H. McKinley & M. Jamieson (Eds.), Handbook of green tea and health research (pp. 301-323). New York: Nova. Smith, P. F., Darlington, C. L., & Zheng, Y. (2009). Cognitive deficits following complete bilateral loss of vestibular function and their relationship to the hippocampus. In A. Lindqvist & G. Nyman (Eds.), Dizziness: Vertigo, disequilibrium and lightheadedness . New York: Nova Science.

Journal - Research Article Alexander, A., Smith, P. F., & Rosengren, R. J. (2009). Cannabinoids in the treatment of cancer. Cancer Letters, 285(1), 6-12. doi: 10.1016/j.canlet.2009.04.005 Baek, J. h., Zheng, Y., Darlington, C. L., & Smith, P. (2010). Evidence that spatial memory deficits following bilateral vestibular deafferentation in rats are probably permanent. Neurobiology of Learning and Memory, 94(3), 402-413. doi: 10.1016/j. nlm.2010.08.007

Baek, J. H., Zheng, Y., Darlington, C. L., & Smith, P. F. (2010). Cannabinoid CB1 receptor expression and affinity in the rat hippocampus following bilateral vestibular deafferentation. Neuroscience Letters, Advance Online Publication. doi: 10.1016/j.neulet.2010.10.050 Chindo, B. A., Anuka, J. A., McNeil, L., ..., Connelly, W. K., Lees, G., et al. (2009). Anticonvulsant properties of saponins from Ficus platyphylla stem bark. Brain Research Bulletin, 78(6), 276-282. doi: 10.1016/j.brainresbull.2008.12.005 Connelly, W. M., & Baggott, M. J. (2009). Role of endocannabinoids in 5-HT2 receptor-mediated effects. Journal of Neurophysiology, 101(1), 5-7. doi: 10.1152/jn.91054.2008 Connelly, W. M., & Lees, G. (2010). Modulation and function of the autaptic connections of layer V fast spiking interneurons in the rat neocortex. Journal of Physiology, 588(12), 2047-2063. doi: 10.1113/jphysiol.2009.185199 Connelly, W. M., Schulz, J. M., Lees, G., & Reynolds, J. N. J. (2010). Differential short-term plasticity at convergent inhibitory synapses to the substantia nigra pars reticulata. Journal of Neuroscience, 30(44), 14854-14861. doi: 10.1523/ JNEUROSCI.3895-10.2010 Connelly, W. M., Shenton, F. C., Lethbridge, N., Leurs, R., Waldvogel, H. J., Faull, R. L. M., Lees, G., & Chazot, P. L. (2009).

The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS. British Journal of Pharmacology, 157(1), 55-63. doi: 10.1111/j.1476-5381.2009.00227.x Darlington, C. L., Goddard, M., Zheng, Y., & Smith, P. F. (2009). Anxiety-related behavior and biogenic amine pathways in the rat following bilateral vestibular lesions. Annals of the New York Academy of Sciences, 1164(1), 134-139. doi: 10.1111/j.1749- 6632.2008.03725.x Fraser, A., Haines, S. R., Stuart, E. C., Scandlyn, M. J., Alexander, A., Somers-Edgar, T. J., & Rosengren, R. J. (2010). Deer velvet supplementation decreases the grade and metastasis of azoxymethane-induced colon cancer in the male rat. Food and Chemical Toxicology, 48, 1288-1292. doi: 10.1016/j.fct.2010.02.024 Goddard, M., Smith, P. F., & Ashton, J. C. (2010). Behavioural effects of co-administration of D9-tetrahydrocannabinol with fluoxetine in rats. Pharmacology, 86(2), 125-128. doi: 10.1159/000317059 Goulton, C. S., Patten, A. R., Kerr, J. R., & Kerr, D. S. (2010). Pharmacological preconditioning with GYKI 52466: A prophylactic approach to neuroprotection. Frontiers in Neuroscience, 4, 54. doi: 10.3389/fnins.2010.00054 Graham, E. S., Ashton, J. C., & Glass, M. (2009). Cannabinoid receptors: A brief history and ‘What’s hot’. Frontiers in Bioscience, 14, 944-957. doi: 10.2741/3288

138 RESEARCH REPORT 2009/2010 ha Baek, J., Zheng, Y., Darlington, C. L., & Smith, P. F. (2009). The CB1 receptor agonist, WIN 55,212-2, dose-dependently disrupts object recognition memory in adult rats. Neuroscience Letters, 464(1), 71-73. doi: 10.1016/j.neulet.2009.08.008 Imlach, W. L., Finch, S. C., Dunlop, J., & Dalziel, J. E. (2009). Structural determinants of lolitrems for inhibition of BK large conductance Ca2+-activated K+ channels. European Journal of Pharmacology, 605(1-3), 36-45. doi: 10.1016/j. ejphar.2008.12.031 Imlach, W. L., Finch, S. C., Miller, J. H., Meredith, A. L., & Dalziel, J. E. (2010). A role for BK channels in heart rate regulation in rodents. PLoS ONE, 5(1), e8698. doi: 10.1371/journal.pone.0008698 Lees, G., & Shipton, E. (2009). Voltage-gated sodium channels in nociception and their potential as targets for new drugs in treatment of chronic neuropathic pain. Current Anaesthesia and Critical Care, 20(5-6), 204-208. doi: 10.1016/j. cacc.2009.06.002 Liu, P., Zhang, H., Devaraj, R., Ganesalingam, G., & Smith, P. F. (2010). A multivariate analysis of the effects of aging on glutamate, GABA and arginine metabolites in the rat vestibular nucleus. Hearing Research, 269(1-2), 122-133. doi: 10.1016/j.heares.2010.06.019 Rivers, J. R., & Ashton, J. C. (2010). The development of cannabinoid CBII receptor agonists for the treatment of central neuropathies. Central Nervous System Agents in Medicinal Chemistry, 10(1), 47-64. doi: 10.2174/187152410790780145 Sawant, P. M., Mountfort, D. O., & Kerr, D. S. (2010). Spectral analysis of electrocorticographic activity during pharmacological preconditioning and seizure induction by intrahippocampal domoic acid. Hippocampus, 20(8), 994- 1002. doi: 10.1002/hipo.20698 Sawant, P. M., Tyndall, J. D. A., Holland, P. T., Peake, B. M., Mountfort, D. O., & Kerr, D. S. (2010). In vivo seizure induction and affinity studies of domoic acid and isodomoic acids-D, -E and -F. Neuropharmacology, 59, 129-138. doi: 10.1016/j. neuropharm.2010.03.019 Smith, P. F. (2010). New approaches in the management of spasticity in multiple sclerosis patients: Role of cannabinoids. Therapeutics and Clinical Risk Management, 6, 59-63. Smith, P. F., Brandt, T., Strupp, M., Darlington, C. L., & Zheng, Y. (2009). Balance before reason in rats and humans. Annals of the New York Academy of Sciences, 1164(1), 127-133. doi: 10.1111/j.1749-6632.2008.03726.x Smith, P. F., & Darlington, C. L. (2010). A possible explanation for dizziness following SSRI discontinuation. Acta Oto- Laryngologica, 130, 981-983. doi: 10.3109/00016481003602082

Somers-Edgar, T. J., & Rosengren, R. J. (2009). Coenzyme Q0 induces apoptosis and modulates the cell cycle in estrogen receptor negative breast cancer cells. Anti-Cancer Drugs, 20(1), 33-40. doi: 10.1097/CAD.0b013e328314b5c5 Stuart, E. C., Jarvis, R. M., & Rosengren, R. J. (2010). In vitro mechanism of action for the cytotoxicity elicited by the combination of epigallocatechin gallate and raloxifene in MDA-MB-231 cells. Oncology Reports, 24(3), 779-785. doi: 10.3892/or_00000921 Sutherland, B. A., Rahman, R. M. A., Clarkson, A. N., Shaw, O. M., Nair, S. M., & Appleton, I. (2009). Cerebral heme oxygenase 1 and 2 spatial distribution is modulated following injury from hypoxia-ischemia and middle cerebral artery occlusion in rats. Neuroscience Research, 65(4), 326-334. doi: 10.1016/j.neures.2009.08.007 van Rensburg, R., Errington, D. R., Ennaceur, A., Lees, G., Obrenovitch, T. P., & Chazot, P. L. (2009). A new model for the study of high-K+-induced preconditioning in cultured neurones: Role of N-methyl-d-aspartate and a7-nicotinic acetylcholine receptors. Journal of Neuroscience Methods, 177(2), 311-316. doi: 10.1016/j.jneumeth.2008.10.012 Yadav, B., Taurin, S., Rosengren, R. J., Schumacher, M., Diederich, M., Somers-Edgar, T. J., & Larsen, L. (2010). Synthesis and cytotoxic potential of heterocyclic cyclohexanone analogues of curcumin. Bioorganic & Medicinal Chemistry, 18(18), 6701-6707. doi: 10.1016/j.bmc.2010.07.063 Zheng, Y., Balabhadrapatruni, S., Masumura, C., Munro, O., Darlington, C. L., & Smith, P. F. (2009). Bilateral vestibular deafferentation causes deficits in a 5-choice serial reaction time task in rats. Behavioural Brain Research, 203, 113-117. doi: 10.1016/j.bbr.2009.04.027 Zheng, Y., Begum, S., Zhang, C., Fleming, K., Masumura, C., Zhang, M., Smith, P., & Darlington, C. (2010). Increased BrdU incorporation reflecting DNA repair, neuronal de-differentiation or possible neurogenesis in the adult cochlear nucleus following bilateral cochlear lesions in the rat. Experimental Brain Research, Advance Online Publication. doi: 10.1007/ s00221-010-2491-0 Zheng, Y., Goddard, M., Darlington, C. L., & Smith, P. F. (2009). Long-term deficits on a foraging task after bilateral vestibular deafferentation in rats. Hippocampus, 19(5), 480-486. doi: 10.1002/hipo.20533 Zheng, Y., Mason-Parker, B., Logan, B., Darlington, C. L., Smith, P. F., & Abraham, W. C. (2010). Hippocampal synaptic transmission and LTP in vivo are intact following bilateral vestibular deafferentation in the rat. Hippocampus, 20(4), 461- 468. doi: 10.1002/hipo.20645 Zheng, Y., Masumura, C., Chung, P., Darlington, C. L., & Smith, P. F. (2010). Cell proliferation and survival in the vestibular nucleus following bilateral vestibular deafferentation in the adult rat. Neuroscience Letters, 468(1), 85-88. doi: 10.1016/j. neulet.2009.10.070 Zheng, Y., Stiles, L., Hamilton, E., Smith, P. F., & Darlington, C. L. (2010). The effects of the synthetic cannabinoid receptor agonists, WIN55,212-2 and CP55,940, on salicylate-induced tinnitus in rats. Hearing Research, 268(1-2), 145-150. doi: 10.1016/j.heares.2010.05.015 Zheng, Y., Vagal, S., Zhu, X-X., de Waele, C., Smith, P. F., Wang, G., Zhang, M., & Darlington, C. L. (2010). The effects of the Chinese herbal medicine EMF01 on salicylate-induced tinnitus in rats. Journal of Ethnopharmacology, 128, 545-548. doi: 10.1016/j.jep.2010.01.053

Division of HEALTH SCIENCES 139 Journal - Research Other Brownjohn, P. W., & Ashton, J. C. (2009). Novel targets in pain research: The case for CB2 receptors as a biorational pain target. Current Anaesthesia and Critical Care, 20(5-6), 198-203. doi: 10.1016/j.cacc.2009.07.014 Clark, D. (2010). [Review of the book Expecting the worst: A publication from the Uppsala Monitoring Centre]. Drug Safety, Advance Online Publication. Clark, D. (2010). [Review of the book The dawn of drug safety]. Drug Safety, 33(9), 801-802. Lees, G. (2009). Chronic issues: Intractable pain and appraising drug safety post-launch [Forward]. Current Anaesthesia and Critical Care, 20(5-6), 195-197. doi: 10.1016/j.cacc.2009.06.001 Smith, P. F., Darlington, C. L., & Zheng, Y. (2010). Move it or lose it: Is stimulation of the vestibular system necessary for normal spatial memory? Hippocampus, 20, 36-43. doi: 10.1002/hipo.20588 Smith, P. F., Geddes, L. H., Baek, J-H., Darlington, C. L., & Zheng, Y. (2010). Modulation of memory by vestibular lesions and galvanic vestibular stimulation. Frontiers in Neurology, 1, 141. doi: 10.3389/fneur.2010.00141

Otago School of Medical Sciences Department of Physiology

Chapter in Book - Research Roome, C. J., & Empson, R. M. (2010). Assessment of the contribution of the plasma membrane calcium ATPase, PMCA, calcium transporter to synapse function using patch clamp electrophysiology and fast calcium imaging. In Q. Yan (Ed.), Membrane transporters in drug discovery and development: Methods and Protocols [Vol. 637] (pp. 343-360). New York: Springer Science+Business Media. doi: 10.1007/978-1-60761-700-6_19

Journal - Research Article Ábrahám, I. M., Köszegi, Z., Tolod-Kemp, E., & Szegö É. M. (2009). Action of estrogen on survival of basal forebrain cholinergic neurons: Promoting amelioration. Psychoneuroendocrinology, 34, S104-S112. doi: 10.1016/j. psyneuen.2009.05.024 Ádori, M., Kiss, E., Barad, Z., ..., Ábrahám, I., et al. (2010). Estrogen augments the T cell-dependent but not the T-independent immune response. Cellular and Molecular Life Sciences, 67, 1661-1674. doi: 10.1007/s00018-010-0270-5

Ainslie, P. N., & Duffin, J. (2009). Integration of cerebrovascular CO2 reactivity and chemoreflex control of breathing: Mechanisms of regulation, measurement, and interpretation. American Journal of Physiology: Regulatory Integrative and Comparative Physiology, 296(5), R1473-R1495. doi: 10.1152/ajpregu.91008.2008 Al-Salami, H., Butt, G., Tucker, I., Fawcett, P. J., Golocorbin-Kon, S., Mikov, I., & Mikov, M. (2009). Gliclazide reduces MKC intestinal transport in healthy but not diabetic rats. European Journal of Drug Metabolism and Pharmacokinetics, 34(1), 43-50. Bailey, D. M., Evans, K. A., James, P. E., ..., Ainslie, P. N., et al. (2009). Altered free radical metabolism in acute mountain sickness: Implications for dynamic cerebral autoregulation and blood-brain barrier function. Journal of Physiology, 587(1), 73-85. doi: 10.1113/jphysiol.2008.159855 Bartolo, R. C., Harfoot, N., Gill, M., Demmers, K., McLeod, B., & Butt, A. G. (2009). Electrogenic Cl— secretion does not occur in the ileum of the Australian common brushtail possum, Trichosurus vulpecula, due to low levels of expression of the NaK2CL cotransporter, NKCC1. Journal of Comparative Physiology B, 179(8), 997-1010. doi: 10.1007/s00360-009-0379-8 - Bartolo, R. C., Harfoot, N., Gill, M., McLeod, B. J., & Butt, A. G. (2009). Secretagogues stimulate electrogenic HCO3 secretion + - in the ileum of the brushtail possum, Trichosurus vulpecula: Evidence for the role of a Na /HCO3 cotransporter. Journal of Experimental Biology, 212, 2645-2655. doi: 10.1242/jeb.028928 Bhattarai, J. P., Kaszás, A., Park, S. A., Yin, H., Park, S. J., Herbison, A. E., Han, S. K., & Ábrahám, I. (2010). Somatostatin inhibition of gonadotropin-releasing hormone neurons in female and male mice. Endocrinology, 151(7), 3258-3266. doi: 10.1210/en.2010-0148 Bolter, C. P., & Turner, M. J. (2009). Tertiapin-Q removes a large and rapidly acting component of vagal slowing of the guinea- pig cardiac pacemaker. Autonomic Neuroscience, 150, 76-81. doi: 10.1016/j.autneu.2009.05.244 Bouwman, R. A., Vreden, M. J. A., Hamdani, N., Wassenaar, L. E. J., Smeding, L., Loer, S., Stienen, G. J. M., & Lamberts, R. R. (2010). Effect of bupivacaine on sevoflurane-induced preconditioning in isolated rat hearts. European Journal of Pharmacology, 647(1-3), 132-138. doi: 10.1016/j.ejphar.2010.08.014 Brown, R. S. E., Kokay, I. C., Herbison, A. E., & Grattan, D. R. (2010). Distribution of prolactin-responsive neurons in the mouse forebrain. Journal of Comparative Neurology, 518(1), 92-102. doi: 10.1002/cne.22208 Burgess, K. R., Fan, J-L., Peebles, K., Thomas, K., Lucas, S., Lucas, R., Dawson, A., Swart, M., Shepherd, K., & Ainslie, P. (2010). Exacerbation of obstructive sleep apnea by oral indomethacin. Chest, 137(3), 707-710. doi: 10.1378/chest.09-1329 Butler-Munro, C., Coddington, E. J., Shirley, C. H., & Heyward, P. M. (2010). Lithium modulates cortical excitability in vitro. Brain Research, 1352, 50-60. doi: 10.1016/j.brainres.2010.07.021 Campbell, R. E., Gaidamaka, G., Han, S-K., & Herbison, A. E. (2009). Dendro-dendritic bundling and shared synapses between gonadotropin-releasing hormone neurons. PNAS, 106(26), 10835-10840. doi: 10.1073/pnas.0903463106 Campbell, R. E., & Suter, K. J. (2010). Redefining the gonadotrophin-releasing hormone neurone dendrite. Journal of Neuroendocrinology, 22, 650-658. doi: 10.1111/j.1365-2826.2010.02032.x

140 RESEARCH REPORT 2009/2010 Campos, Y., Qiu, X., Zanoteli, E., Moshiach, S., Vergani, N., Bongiovanni, A., Harris, A. J., & d’Azzo, A. (2010). Ozz-E3 ubiquitin ligase targets sarcomeric embryonic myosin heavy chain during muscle development. PLoS ONE, 5(3), e9866. doi: 10.1371/journal.pone.0009866 Chao, P-C., & Hamilton, K. L. (2009). Genistein stimulates electrogenic Cl- secretion via phosphodiesterase modulation in the mouse jejunum. American Journal of Physiology: Cell Physiology, 297(3), C688-C698. doi: 10.1152/ajpcell.00152.2009 Clarkson, J., Boon, W. C., Simpson, E. R., & Herbison, A. E. (2009). Postnatal development of an estradiol-kisspeptin positive feedback mechanism implicated in puberty onset. Endocrinology, 150(7), 3214-3220. doi: 10.1210/en.2008-1733 Clarkson, J., d’Anglemont de Tassigny, X., Colledge, W. H., Caraty, A., & Herbison, A. E. (2009). Distribution of kisspeptin neurones in the adult female mouse brain. Journal of Neuroendocrinology, 21(8), 673-682. Clarkson, J., Han, S-K., Liu, X., Lee, K., & Herbison, A. E. (2010). Neurobiological mechanisms underlying kisspeptin activation of gonadotropin-releasing hormone (GnRH) neurons at puberty. Molecular and Cellular Endocrinology, 324, 45-50. doi: 10.1016/j.mce.2010.01.026 Clarkson, J., & Herbison, A. E. (2009). Oestrogen, kisspeptin, GPR54 and the pre-ovulatory luteinising hormone surge. Journal of Neuroendocrinology, 21(4), 305-311. doi: 10.1111/j.1365-2826.2009.01835.x Condliffe, S. B., Corradini, I., Pozzi, D., Verderio, C., & Matteoli, M. (2010). Endogenous SNAP-25 regulates native voltage- gated calcium channels in glutamatergic neurons. Journal of Biological Chemistry, 285(32), 24968-24976. doi: 10.1074/jbc. M110.145813 Constantin, S., Caligioni, C. S., Stojilkovic, S., & Wray, S. (2009). Kisspeptin-10 facilitates a plasma membrane-driven calcium oscillator in gonadotropin-releasing hormone-1 neurons. Endocrinology, 150(3), 1353-1360. doi: 10.1210/en.2008-1199 Constantin, S., Caraty, A., Wray, S., & Duittoz, A. H. (2009). Development of gonadotropin-releasing hormone-1 secretion in mouse nasal explants. Endocrinology, 150(7), 3221-3227. doi: 10.1210/en.2008-1711 Constantin, S., Jasoni, C. L., Wadas, B., & Herbison, A. E. (2010). g-aminobutyric acid and glutamate differentially regulate intracellular calcium concentrations in mouse gonadotropin-releasing hormone neurons. Endocrinology, 151(1), 262-270. doi: 10.1210/en.2009-0817 Constantin, S., Klenke, U., & Wray, S. (2010). The calcium oscillator of GnRH-1 neurons is developmentally regulated. Endocrinology, 151(8), 3863-3873. doi: 10.1210/en.2010-0118 Cowan, D. C., Hewitt, R. S., Cowan, J. O., Palmay, R., Williamson, A., Lucas, S. J. E., Murrell, C. J., Thomas, K. N., & Taylor, D. R. (2010). Exercise-induced wheeze: Fraction of exhaled nitric oxide-directed management. Respirology, 15, 683-690. doi: 10.1111/j.1440-1843.2010.01740.x Dejean, C., Hyland, B., & Arbuthnott, G. (2009). Cortical effects of subthalamic stimulation correlate with behavioral recovery from dopamine antagonist induced akinesia. Cerebral Cortex, 19(5), 1055-1063. doi: 10.1093/cercor/bhn149 Demmers, K., Carter, D., Fan, S., Mao, P., Maqbool, N. J., McLeod, B. J., Bartolo, R. C., & Butt, A. G. (2010). Molecular and functional characterization of the cystic fibrosis transmembrane conductance regulator from the Australian common brushtail possum, Trichosurus vulpecula. Journal of Comparative Physiology B, 180(4), 545-561. doi: 10.1007/s00360-009- 0433-6 Ducret, E., Anderson, G. M., & Herbison, A. E. (2009). RFamide-related peptide-3, a mammalian gonadotropin-inhibitory hormone ortholog, regulates gonadotropin-releasing hormone neuron firing in the mouse. Endocrinology, 150(6), 2799- 2804. doi: 10.1210/en.2008-1623 Ducret, E., Gaidamaka, G., & Herbison, A. E. (2010). Electrical and morphological characteristics of anteroventral periventricular nucleus kisspeptin and other neurons in the female mouse. Endocrinology, 151, 2223-2232. doi: 10.1210/ en.2009-1480 Egaña, M., Reilly, H., & Green, S. (2010). Effect of elastic-band-based resistance training on leg blood flow in elderly women. Applied Physiology Nutrition and Metabolism, 35(6), 763-772. doi: 10.1139/h10-071 Egaña, M., Ryan, K., Warmington, S. A., & Green, S. (2010). Effect of body tilt angle on fatigue and EMG activities in lower limbs during cycling. European Journal of Applied Physiology, 108(4), 649-656. doi: 10.1007/s00421-009-1254-8 Empson, R. M., Akemann, W., & Knöpfel, T. (2010). The role of the calcium transporter protein plasma membrane calcium ATPase PMCA2 in cerebellar Purkinje neuron function. Functional Neurology, 25(3), 153-163. Empson, R. M., & Knöpfel, T. (2010). Functional integration of calcium regulatory mechanisms at Purkinje neuron synapses. Cerebellum, Advance Online Publication. doi: 10.1007/s12311-010-0185-6 Empson, R. M., Turner, P. R., Nagaraja, R. Y., Beesley, P. W., & Knöpfel, T. (2010). Reduced expression of the Ca2+ transporter protein PMCA2 slows Ca2+ dynamics in mouse cerebellar Purkinje neurons and alters the precision of motor coordination. Journal of Physiology, 588(6), 907-922. doi: 10.1113/jphysiol.2009.182196 Fan, J-L., Burgess, K. R., Basnyat, R., Thomas, K. N., Peebles, K. C., Lucas, S. J., Lucas, R. A., Donnelly, J., Cotter, J. D., & Ainslie,

P. N. (2010). Influence of high altitude on cerebrovascular responsiveness to CO2. Journal of Physiology, 588(3), 539-549. doi: 10.1113/jphysiol.2009.184051 Fan, J-L., Burgess, K. R., Thomas, K. N., Peebles, K. C., Lucas, S. J. E., Lucas, R. A. I., Cotter, J. D., & Ainslie, P. N. (2010). Influence of indomethacin on the ventilatory and cerebrovascular responsiveness to hypoxia. European Journal of Applied Physiology and Occupational Physiology, Advance Online Publication. doi: 10.1007/s00421-010-1679-0 Fan, J-L., Burgess, K. R., Thomas, K. N., Peebles, K. C., Lucas, S. J. E., Lucas, R. A. I., Cotter, J. D., & Ainslie, P. N. (2010).

Influence of indomethacin on ventilatory and cerebrovascular responsiveness to CO2 and breathing stability: The

influence of PCO2 gradients. American Journal of Physiology Regulatory Integrative and Comparative Physiology, 298, 1648- 1658. doi: 10.1152/ajpregu.00721.2009 Galvin, S. D., Celi, L. A., Thomas, K. N., Clendon, T. R., Galvin, I. F., Bunton, R. W., & Ainslie, P. N. (2010). Effects of age and coronary artery disease on cerebrovascular reactivity to carbon dioxide in humans. Anaesthesia and Intensive Care, 38(4), 710-717.

Division of HEALTH SCIENCES 141 García-Galiano, D., Navarro, V. M., Roa, J., Ruiz-Pino, F., Sánchez-Garrido, M. A., et al. (2010). The anorexigenic neuropeptide, Nesfatin-1, is indispensable for normal puberty onset in the female rat. Journal of Neuroscience, 30(23), 7783-7792. doi: 10.1523/JNEUROSCI.5828-09.2010 Garside, M. L., Turner, P. R., Austen, B., Strehler, E. E., Beesley, P. W., & Empson, R. M. (2009). Molecular interactions of the plasma membrane calcium ATPase 2 at pre- and post-synaptic sites in rat cerebellum. Neuroscience, 162(2), 383-395. doi: 10.1016/j.neuroscience.2009.04.059 Green, S., Smith, N. A., & Kerr, G. K. (2010). Electromyographic activity in lower limb muscles is temporally associated with the slow phase of oxygen uptake during cycling. Scandinavian Journal of Medicine & Science in Sports, 20(2), 310-319. doi: 10.1111/j.1600-0838.2009.00893.x Hale, L. A., Nukada, H., Du Plessis, L. J., & Peebles, K. C. (2009). Clinical screening of autonomic dysfunction in multiple sclerosis. Physiotherapy Research International, 14(1), 42-55. doi: 10.1002/pri.416 Han, S-K., Lee, K., Bhattarai, J. P., & Herbison, A. E. (2010). Gonadotrophin-releasing hormone (GnRH) exerts stimulatory effects on GnRH neurones in intact adult male and female mice. Journal of Neuroendocrinology, 22(3), 188-195. doi: 10.1111/j.1365-2826.2009.01950.x Han, S. Y., Wilson, S. J., & Bolter, C. P. (2010). Tertiapin-Q removes a mechanosensitive component of muscarinic control of the sinoatrial pacemaker in the rat. Clinical and Experimental Pharmacology and Physiology, 37, 900-904. doi: 10.1111/j.1440-1681.2010.05408.x Han, T. H., Lee, K., Park, J. B., Ahn, D., Park, J-H., Kim, D-Y., et al. (2010). Reduction in synaptic GABA release contributes to target-selective elevation of PVN neuronal activity in rats with myocardial infarction. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 299(1), R129-R139. doi: 10.1152/ajpregu.00391.2009 Herbison, A. E. (2009). Rapid actions of oestrogen on gonadotropin-releasing hormone neurons: From fantasy to physiology? Journal of Physiology, 587(21), 5025-5030. doi: 10.1113/jphysiol.2009.179838 Herbison, A. E., d’Anglemont de Tassigny, X., Doran, J., & Colledge, W. H. (2010). Distribution and postnatal development of Gpr54 gene expression in mouse brain and gonadotropin-releasing hormone neurons. Endocrinology, 151(1), 312-321. doi: 10.1210/en.2009-0552 Heyward, P. M. (2010). A brain slice bath for physiology and compound microscopy, with dual-sided perifusion. Journal of Microscopy, 240(3), 207-215. doi: 10.1111/j.1365-2818.2010.03382.x Igelstrom, K. M., Herbison, A. E., & Hyland, B. I. (2010). Enhanced c-Fos expression in superior colliculus, paraventricular thalamus and septum during learning of cue-reward association. Neuroscience, Advance Online Publication. doi: 10.1016/j. neuroscience.2010.04.018 Iremonger, K. J., Benediktsson, A. M., & Bains, J. S. (2010). Glutamatergic synaptic transmission in neuroendocrine cells: Basic principles and mechanisms of plasticity. Frontiers in Neuroendocrinology, 31(3), 296-306. doi: 10.1016/j.yfrne.2010.03.002 Iremonger, K. J., Constantin, S., Liu, X., & Herbison, A. E. (2010). Glutamate regulation of GnRH neuron excitability. Brain Research, Advance Online Publication. doi: 10.1016/j.brainres.2010.08.071 Jasoni, C. L., Porteous, R. W., & Herbison, A. E. (2009). Anatomical location of mature GnRH neurons corresponds with their birthdate in the developing mouse. Developmental Dynamics, 238(3), 524-531. Jasoni, C. L., Romanà, N., Constantin, S., Lee, K., & Herbison, A. E. (2010). Calcium dynamics in gonadotropin-releasing hormone neurons. Frontiers in Neuroendocrinology, 31, 259-269. doi: 10.1016/j.yfrne.2010.05.005 Jensen, T. P., Buckby, L. E., & Empson, R. M. (2009). Reduced expression of the “fast” calcium transporter PMCA2a during homeostatic plasticity. Molecular and Cellular Neuroscience, 41(3), 364-372. doi: 10.1016/j.mcn.2009.04.011 Jiang, D., Jones, P. P., Davis, D. R., Gow, R., Green, M. S., Birnie, D. H., et al. (2010). Characterization of a novel mutation in the cardiac ryanodine receptor that results in catecholaminergic polymorphic ventricular tachycardia. Channels, 4(4), 12666. doi: 10.4161/chan.4.4.12666 Kennedy, D., Kieser, J., Bolter, C., Swain, M., Singh, B., & Waddell, J. N. (2010). Tongue pressure patterns during water swallowing. Dysphagia, 25, 11-19. doi: 10.1007/s00455-009-9223-2 Ke, Y., Butt, A. G., Swart, M., Liu, Y-f., & McDonald, F. J. (2010). COMMD1 down-regulates the epithelial sodium channel through Nedd4-2. American Journal of Physiology - Renal Physiology, 298, F1445-F1456. doi: 10.1152/ajprenal.00257.2009 Kishimoto, I., Tokudome, T., Schwenke, D. O., Takeshi, S., Hosoda, H., Nagaya, N., & Kangawa, K. (2009). Therapeutic potential of ghrelin in cardiac diseases. Expert Review of Endocrinology & Metabolism, 4(3), 283-289. Klenke, U., Constantin, S., & Wray, S. (2010). Neuropeptide Y directly inhibits neuronal activity in a subpopulation of gonadotropin-releasing hormone-1 neurons via Y1 receptors. Endocrinology, 151(6), 2736-2746. doi: 10.1210/en.2009-1198 Lee, K., Duan, W., Sneyd, J., & Herbison, A. E. (2010). Two slow calcium-activated afterhyperpolarization currents control burst firing dynamics in gonadotropin-releasing hormone neurons. Journal of Neuroscience, 30(18), 6214-6224. doi: 10.1523/JNEUROSCI.6156-09.2010

Lee, K., Porteous, R., Campbell, R. E., Lüscher, B., & Herbison, A. E. (2010). Knockdown of GABAa receptor signaling in GnRH neurons has minimal effects upon fertility. Endocrinology, 151(9), 4428-4436. doi: 10.1210/en.2010-0314 Lewis, N. C. S., Atkinson, G., Lucas, S. J. E., Grant, E. J. M., Jones, H., Tzeng, Y. C., Horsman, H., & Ainslie, P. N. (2010). Diurnal variation in time to presyncope and associated circulatory changes during a controlled orthostatic challenge. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 68(1), R55-R61. doi: 10.1152/ajpregu.00030.2010 Lucas, R. A. I., Ainslie, P. N., Fan, J-L., Wilson, L. C., Thomas, K. N., & Cotter, J. D. (2010). Skin cooling aids cerebrovascular function more effectively under severe than moderate heat stress. European Journal of Applied Physiology and Occupational Physiology, 109, 101-108. doi: 10.1007/s00421-009-1298-9

142 RESEARCH REPORT 2009/2010 Lucas, S. J. E., Tzeng, Y. C., Galvin, S. D., Thomas, K. N., Ogoh, S., & Ainslie, P. N. (2010). Influence of changes in blood pressure on cerebral perfusion and oxygenation. Hypertension, 55, 698-705. doi: 10.1161/ HYPERTENSIONAHA.109.146290 Mabuchi, A., Wake, K., Marlini, M., Watanabe, H., & Wheatley, A. M. (2009). Protection by glycyrrhizin against warm ischemia-reperfusion-induced cellular injury and derangement of the microcirculatory blood flow in the rat liver. Microcirculation, 16(4), 364-376. doi: 10.1080/10739680902796917 MacAnaney, O., Malone, J., Warmington, S., O’Shea, D., Green, S., & Egaña, M. (2010). Cardiac output is not related to the

slowed O2 uptake kinetics in type 2 diabetes. Medicine and Science in Sports and Exercise, Advance Online Publication. doi: 10.1249/MSS.0b013e3182061cdb Matteoli, M., Pozzi, D., Grumelli, C., Condliffe, S. B., Frassoni, C., Harkany, T., & Verderio, C. (2009). The synaptic split of SNAP-25: Different roles in glutamatergic and GABAergic neurons? Neuroscience, 158, 223-230. doi: 10.1016/j. neuroscience.2008.03.014 McKelvey, K. J., Highton, J., & Hessian, P. A. (2010). Cell-specific expression of TLR9 isoforms in inflammation. Journal of Autoimmunity, Advance Online Publication. doi: 10.1016/j.jaut.2010.11.001 Merry, T. L., Ainslie, P. N., & Cotter, J. D. (2010). Effects of aerobic fitness on hypohydration-induced physiological strain and exercise impairment. Acta Physiologica, 198(2), 179-190. doi: 10.1111/j.1748-1716.2009.02051.x Mufti, R. E., Brett, S. E., Tran, C. H. T., ..., Jones, P. P., Chen, S. R. W., & Welsh, D. G. (2010). Intravascular pressure augments cerebral arterial constriction by inducing voltage-insensitive Ca2+ waves. Journal of Physiology, 588(20), 3983-4005. doi: 10.1113/jphysiol.2010.193300 Murrell, C. J., Cotter, J. D., George, K. P., Shave, R., Wilson, L. C., Thomas, K. N., Williams, M. J. A., Lowe, T., & Ainslie, P. N. (2009). Influence of age on syncope following prolonged exercise: Differential responses but similar orthostatic intolerance. Journal of Physiology, 587(24), 5959-5969. doi: 10.1113/jphysiol.2009.179549 Murrell, C. J., Cotter, J. D., George, K., Shave, R., Wilson, L., Thomas, K., Williams, M. J. A., & Ainslie, P. N. (2010). Cardiorespiratory and cerebrovascular responses to head-up tilt I: Influence of age and training status. Experimental Gerontology, Advance Online Publication. doi: 10.1016/j.exger.2010.06.005 Murrell, C. J., Cotter, J. D., George, K., Shave, R., Wilson, L., Thomas, K., Williams, M. J. A., & Ainslie, P. N. (2010). Cardiorespiratory and cerebrovascular responses to head-up tilt II: Influence of age, training status and acute exercise. Experimental Gerontology, Advance Online Publication. doi: 10.1016/j.exger.2010.06.004 Murrell, C. J., Cotter, J. D., George, K., Shave, R., Wilson, L., Thomas, K., Williams, M. J. A., & Ainslie, P. N. (2010). Syncope is unrelated to supine and postural hypotension following prolonged exercise. European Journal of Applied Physiology and Occupational Physiology, Advance Online Publication. doi: 10.1007/s00421-010-1671-8 Ogoh, S., & Ainslie, P. N. (2009). Regulatory mechanisms of cerebral blood flow during exercise: New concepts. Exercise and Sport Sciences Reviews, 37(3), 123-129. doi: 10.1097/JES.0b013e3181aa64d7 Ogoh, S., Ainslie, P. N., & Miyamoto, T. (2009). Onset responses of ventilation and cerebral blood flow to hypercapnia in humans: Rest and exercise. Journal of Applied Physiology, 106(3), 880-886. doi: 10.1152/japplphysiol.91292.2008 Ogoh, S., Tzeng, Y-C., Lucas, S. J. E., Galvin, S. D., & Ainslie, P. N. (2010). Influence of baroreflex-mediated tachycardia on the regulation of dynamic cerebral perfusion during acute hypotension in humans. Journal of Physiology, 588(2), 365-371. doi: 10.1113/jphysiol.2009.180844 Oxborough, D., Batterham, A. M., Shave, R., Artis, N., Birch, K. M., Whyte, G., Ainslie, P. N., & George, K. P. (2009). Interpretation of two-dimensional and tissue Doppler-derived strain (e) and strain rate data: Is there a need to normalize for individual variability in left ventricular morphology? European Journal of Echocardiography, 10(5), 677-682. doi: 10.1093/ejechocard/jep037 Parr-Brownlie, L., Poloskey, S. L., Bergstrom, D. A., & Walters, J. R. (2009). Parafascicular thalamic nucleus activity in a rat model of Parkinson’s disease. Experimental Neurology, 217(2), 269-281. doi: 10.1016/j.expneurol.2009.02.010 Pearson, J. T., Schwenke, D. O., Jenkins, M. J., Edgley, A. J., Sonobe, T., et al. (2010). Benefits of synchrotron microangiography for dynamic studies of smooth muscle and endothelial roles in the pathophysiology of vascular disease. AIP Conference Proceedings, 1266(1), 84-88. doi: 10.1063/1.3478204 Peng, T., Rowley, A. B., Ainslie, P. N., Poulin, M. J., & Payne, S. J. (2010). Wavelet phase synchronization analysis of cerebral blood flow autoregulation. IEEE Transactions on Biomedical Engineering, 57(4), 960-968. doi: 10.1109/TBME.2009.2024265 Perez, D., Rudland, J. R., Wilson, H., Roberton, G., Gerrard, D., & Wheatley, A. (2009). The revised ‘Early Learning in Medicine’ curriculum at the University of Otago: Focusing on students, patients, and community. New Zealand Medical Journal, 122(1292). Retrieved from http://www.nzma.org.nz/journal/122-1292/3540/ Quennell, J. H., Mulligan, A. C., Tups, A., Liu, X., Phipps, S. J., Kemp, C. J., Herbison, A. E., Grattan, D. R., & Anderson, G. M. (2009). Leptin indirectly regulates gonadotropin-releasing hormone neuronal function. Endocrinology, 150(6), 2805-2812. doi: 10.1210/en.2008-1693 Rizwan, M. Z., Porteous, R., Herbison, A. E., & Anderson, G. M. (2009). Cells expressing RFamide-related peptide-1/3, the mammalian gonadotropin-inhibitory hormone orthologs, are not hypophysiotropic neuroendocrine neurons in the rat. Endocrinology, 150(3), 1413-1420. doi: 10.1210/en.2008-1287 Roa, J., García-Galiano, D., Castellano, J. M., Gayton, F., Pinilla, L., & Tena-Sempere, M. (2010). Metabolic control of puberty onset: New players, new mechanisms. Molecular and Cellular Endocrinology, 324, 87-94. doi: 10.1016/j.mce.2009.12.018 Roa, J., & Tena-Sempere, M. (2010). Energy balance and puberty onset: Emerging role of central mTOR signaling. Trends in Endocrinology and Metabolism, 21(9), 519-528. doi: 10.1016/j.tem.2010.05.003 Ruan, M., & Brown, C. H. (2009). Feedback inhibition of action potential discharge by endogenous adenosine enhancement of the medium afterhyperpolarization. Journal of Physiology, 587(Pt 5), 1043-1056.

Division of HEALTH SCIENCES 143 Russold, M. F., Ramnarine, I., Ashley, Z., Sutherland, H., Salmons, S., & Jarvis, J. C. (2010). Practical and effective stomal sphincter creation: Evaluation in pigs. Diseases of the Colon & Rectum, 53(4), 467-474. doi: 10.1007/ DCR.0b013e3181bdbe91 Sárvári, M., Szegő, É. M., Barabás, K., Jávor, A., Tóth, S., Kovács, Z., & Ábrahám, I. M. (2009). Genistein induces phosphorylation of cAMP response element-binding protein in neonatal hypothalamus In Vivo. Journal of Neuroendocrinology, 21(12), 1024-1028. doi: 10.1111/j.1365-2826.2009.01925.x Schep, L. J., Temple, W. A., Butt, G. A., & Beasley, M. D. (2009). Ricin as a weapon of mass terror: Separating fact from fiction. Environment International, 35(8), 1267-1271. doi: 10.1016/j.envint.2009.08.004 Schultz, M., & Butt, G. (2010). E. coli Nissle 1917 in the treatment of inflammatory bowel disease. Practical Gastroenterology, 34(3), 11-19. Schwenke, D. O., Pearson, J. T., Kangawa, K., Cragg, P. A., & Shirai, M. (2010). Exogenous ghrelin accentuates the acute hypoxic ventilatory response after two weeks of chronic hypoxia in conscious rats. Acta Physiologica, Advance Online Publication. doi: 10.1111/j.1748-1716.2010.02142.x Schwenke, D. O., Pearson, J. T., Shimochi, A., Kangawa, K., Tsuchimochi, H., Umetani, K., Shirai, M., & Cragg, P. A. (2009). Changes in pulmonary blood flow distribution in monocrotaline compared with hypoxia-induced models of pulmonary hypertension: Assessed using synchrotron radiation. Journal of Hypertension, 27(7), 1410-1419. doi: 10.1097/ HJH.0b013e32832af6a1 Scott, V., Bishop, V. R., Leng, G., & Brown, C. H. (2009). Dehydration-induced modulation of k-opioid inhibition of vasopressin neurone activity. Journal of Physiology, 587(23), 5679-5689. doi: 10.1113/jphysiol.2009.180232 Scott, V., & Brown, C. H. (2010). State-dependent plasticity in vasopressin neurones: Dehydration-induced changes inactivity patterning. Journal of Neuroendocrinology, 22(5), 343-354. doi: 10.1111/j.1365-2826.2010.01961.x Sheard, P. W., Bewick, G. S., Woolley, A. G., Shaw, J., Fisher, L., Fong, S. W., & Duxson, M. J. (2010). Investigation of neuromuscular abnormalities in neurotrophin-3-deficient mice. European Journal of Neuroscience, 31(1), 29-41. doi: 10.1111/j.1460-9568.2009.07032.x Shirai, M., Schwenke, D. O., Eppel, G. A., Evans, R. G., Edgley, A. J., Tsuchimochi, H., Umetani, K., & Pearson, J. T. (2009). Synchrotron-based angiography for investigation of the regulation of vasomotor function in the microcirculation in vivo. Clinical and Experimental Pharmacology and Physiology, 36(1), 107-116. doi: 10.1111/j.1440-1681.2008.05073.x Shirley, C. H., Coddington, E. J., & Heyward, P. M. (2010). All-or-none population bursts temporally constrain surround inhibition between mouse olfactory glomeruli. Brain Research Bulletin, 81(4-5), 406-415. doi: 10.1016/j. brainresbull.2009.10.022 Stamp, L. K., Easson, A., Pettersson, L., Highton, J., & Hessian, P. A. (2009). Monocyte derived interleukin (IL)-23 is an important determinant of synovial IL-17A expression in rheumatoid arthritis. Journal of Rheumatology, 36(11), 2403- 2408. doi: 10.3899/jrheum.081304 Sutherland, K. R., Alsop, B., McNaughton, N., Hyland, B. I., Tripp, G., & Wickens, J. R. (2009). Sensitivity to delay of reinforcement in two animal models of attention deficit hyperactivity disorder (ADHD). Behavioural Brain Research, 205(2), 372-376. doi: 10.1016/j.bbr.2009.07.011 Sutherland, W. H. F., de Jong, S. A., Hessian, P. A., & Williams, M. J. A. (2010). Ingestion of native and thermally oxidized polyunsaturated fats acutely increases circulating numbers of endothelial microparticles. Metabolism, 59(3), 446-453. doi: 10.1016/j.metabol.2009.07.033 Thomas, K. N., Burgess, K. R., Basnyat, R., Lucas, S. J. E., Cotter, J. D., Fan, J-L., Peebles, K. C., Lucas, R. A. I., & Ainslie, P. N. (2010). Initial orthostatic hypotension at high altitude. High Altitude Medicine & Biology, 11(2), 163-167. doi: 10.1089/ ham.2009.1056 Thomas, K. N., Cotter, J. D., Galvin, S. D., Williams, M. J. A., Willie, C. K., & Ainslie, P. N. (2009). Initial orthostatic hypotension is unrelated to orthostatic tolerance in healthy young subjects. Journal of Applied Physiology, 107(2), 506-517. doi: 10.1152/japplphysiol.91650.2008 Tzeng, Y-C., Lucas, S. J. E., Atkinson, G., Willie, C. K., & Ainslie, P. N. (2010). Fundamental relationships between arterial baroreflex sensitivity and dynamic cerebral autoregulation in humans. Journal of Applied Physiology, 108, 1162-1168. doi: 10.1152/japplphysiol.01390.2009 Tzeng, Y. C., Sin, P. Y. W., Lucas, S. J. E., & Ainslie, P. N. (2009). Respiratory modulation of cardio-vagal baroreflex sensitivity. Journal of Applied Physiology, 107, 718-724. doi: 10.1152/japplphysiol.00548.2009 Tzeng, Y-C., Willie, C. K., Atkinson, G., Lucas, S. J. E., Wong, A., & Ainslie, P. N. (2010). Cerebrovascular regulation during transient hypotension and hypertension in humans. Hypertension, 56, 268-273. doi: 10.1161/ HYPERTENSIONAHA.110.152066 van Woerden, G. M., Hoebeek, F. E., Gao, Z., Nagaraja, R. Y., Hoogenraad, C. C., Kushner, S. A., et al. (2009). bCaMKII controls the direction of plasticity at parallel fiber-Purkinje cell synapses. Nature Neuroscience, 12(7), 823-825. doi: 10.1038/ nn.2329 Walker, R., Spronken-Smith, R., Bond, C., McDonald, F., Reynolds, J., & McMartin, A. (2010). The impact of curriculum change on health sciences first year students’ approaches to learning. Instructional Science, 38(6), 707-722. doi: 10.1007/ s11251-009-9092-y Wiemuth, D., Lott, J. S., Ly, K., Ke, Y., Teesdale-Spittle, P. H., Snyder, P. M., & McDonald, F. J. (2010). Interaction of Serum- and Glucocorticoid regulated Kinase 1 (SGK1) with the WW-domains of NeDD4-2 is required for epithelial sodium channel regulation. PLoS ONE, 5(8), e12163. doi: 10.1371/journal.pone.0012163

144 RESEARCH REPORT 2009/2010 Williams, K., Gregson, W., Robertson, C., Datson, N., Whyte, G., Murrell, C., Wilson, L., Ainslie, P., et al. (2009). Alterations in left ventricular function and cardiac biomarkers as a consequence of repetitive endurance cycling. European Journal of Sport Science, 9(2), 97-105. doi: 10.1080/17461390902763391 Wilson, L. C., Cotter, J. D., Fan, J-L., Lucas, R. A. I., Thomas, K. N., & Ainslie, P. N. (2010). Cerebrovascular reactivity and dynamic autoregulation in tetraplegia. American Journal of Physiology Regulatory Integrative and Comparative Physiology, 298, R1035-R1042. doi: 10.1152/ajpregu.00815.2009 Wilson, M., O’Hanlon, R., Basavarajaiah, S., George, K., Green, D., Ainslie, P., ..., Murrell, C., et al. (2010). Cardiovascular function and the veteran athlete. European Journal of Applied Physiology, 110, 459-478. doi: 10.1007/s00421-010-1534-3 Wu, Y. -N., Chen, J-J. J., Zhang, L-Q., & Hyland, B. I. (2009). Regulation of hind-limb tone by adenosine A2A receptor in rats. Neuroscience, 159(4), 1408-1413. doi: 10.1016/j.neuroscience.2009.01.068 Zanoteli, E., van de Vlekkert, D., Bonten, E. J., ..., Harris, A. J., Ghersi, G., & d’Azzo, A. (2010). Muscle degeneration in neuraminidase 1-deficient mice results from infiltration of the muscle fibers by expanded connective tissue. Biochimica et Biophysica Acta (BBA): Molecular Basis of Disease, 1802, 659-672. doi: 10.1016/j.bbadis.2010.04.002

Journal - Research Other Ainslie, P. N. (2009). Cardiorespiratory fitness: A simple, cheap and nonpharmacological means to prevent stroke? [Letter to the editor]. Stroke, 40(1), E7. doi: 10.1161/strokeaha.108.534321 Ainslie, P. N. (2009). Have a safe night: Intimate protection against cerebral hyperperfusion during REM sleep [Invited editorial]. Journal of Applied Physiology, 106(4), 1031-1033. doi: 10.1152/japplphysiol.00091.2009 Ainslie, P. N., Willie, C. K., & Tzeng, Y. C. (2009). Role of SNA in the pathophysiology of cardiovascular collapse during syncope: Muscle vs. Brain [Letter]. Journal of Physiology, 587(23), 5795-5796. doi: 10.1113/jphysiol.2009.182667 Lucas, S. J. E., Tzeng, Y. C., & Ainslie, P. N. (2010). Response to The cerebrovascular pressure-flow relationship: A simple concept but a complex phenomenon [Letter]. Hypertension, 56, e3. doi: 10.1161/HYPERTENSIONAHA.110.153312 Piet, R., & Manzoni, O. J. (2010). Prime time for stress [News and views]. Nature Neuroscience, 13(10), 1156-1158. doi: 10.1038/nn1010-1156 Schultz, M., Roberts, R. L., & Butt, A. G. (2010). Understanding probiotic treatment strategies in inflammatory bowel disease, with a special emphasis on the intestinal barrier. European Gastroenterology & Hepatology Review, 6(1), 58-65. Tzeng, S. Y. C., Sin, P. Y. W., & Ainslie, P. N. (2009). Sinus arrhythmia and baroreflex sensitivity: Intimate relationship or separate identities? [Letter to the editor]. Journal of Applied Physiology, 106(5), 1745-1746.

Journal - Professional & Other Non-Research Articles Brown, C. H., Oiso, Y., & Ueta, Y. (2010). Vasopressin and oxytocin: Focus in the post-genomic era [Editorial]. Journal of Neuroendocrinology, 22, 317. doi: 10.1111/j.1365-2826.2010.01985.x Lucas, S. (2009). The ageing musculoskeletal system: Human and Exercise Physiology KCL 09 Themed Meeting [Conference report]. Physiology News, 75, 9.

Intellectual Property Turney, S., & Sheard, P. W. (2009). System and methods for thick specimen imaging using a microscope-based tissue sectioning device. (WO/2009/048524).

Dunedin School of Medicine DEAN’S DEPARTMENT

Chapter in Book - Research Gerrard, D. F. (2009). Playing foreign policy games: States, drugs and other Olympian vices. In S. J. Jackson & S. Haigh (Eds.), Sport and foreign policy in a globalizing world (pp. 111-118). London: Routledge.

Journal - Research Article Avenell, A., Gillespie, W. J., Gillespie, L. D., & O’Connell, D. (2009). Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis. Cochrane Database of Systematic Reviews, 2, CD000227. doi: 10.1002/14651858.CD000227.pub3 Cleland, J. A., Abbott, J. H., Kidd, M. O., Stockwell, S., Cheney, S., Gerrard, D. F., & Flynn, T. W. (2009). Manual physical therapy and exercise versus electrophysical agents and exercise in the management of plantar heel pain: A multicenter randomized clinical trial. Journal of Orthopaedic and Sports Physical Therapy, 39(8), 573-585. doi: 10.2519/jospt.2009.3036 Dockerty, J. D. (2009). Epidemiology of childhood leukemia in New Zealand: Studies of infectious hypotheses. Blood Cells, Molecules, and Diseases, 42(2), 113-116. doi: 10.1016/j.bcmd.2008.10.008 Farry, P., Adams, J., Walters, L., Worley, P., & Dovey, S. (2010). Development of the Rural Immersion Programme for 5th-year medical students at the University of Otago. New Zealand Medical Journal, 123(1323). Retrieved from http://www.nzma. org.nz/journal/123-1323/4356/ Gane, E. J., Weilert, F., Orr, D. W., ..., Frampton, C. M., Taylor, K. M., Smith, R. A. J., & Murphy, M. P. (2010). The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients. Liver International, 30(7), 1019-1026. doi: 10.1111/j.1478-3231.2010.02250.x

Division of HEALTH SCIENCES 145 Gillespie, L. D., Robertson, M. C., Gillespie, W. J., Lamb, S. E., Gates, S., Cumming, R. G., & Rowe, B. H. (2009). Interventions for preventing falls in older people living in the community. Cochrane Database of Systematic Reviews, (2), CD007146. doi: 10.1002/14651858.CD007146.pub2 Herbison, P., Hay-Smith, J., & Gillespie, W. J. (2010). Meta-analyses of small numbers of trials often agree with longer-term results. Journal of Clinical Epidemiology, Advance Online Publication. doi: 10.1016/j.jclinepi.2010.02.017 McKimm, J., Sheehan, D., Poole, P., Barrow, M., Dockerty, J., Wilkinson, T. J., & Wearn, A. (2010). Interprofessional learning in medical education in New Zealand. New Zealand Medical Journal, 123(1320). Retrieved from http://www.nzma.org.nz/ journal/archive.php Mountjoy, M., Junge, A., Alonso, J. M., Engebretsen, L., Dragan, I., Gerrard, D., et al. (2010). Sports injuries and illnesses in the 2009 FINA World Championships (Aquatics). British Journal of Sports Medicine, 44(7), 522-527. doi: 10.1136/ bjsm.2010.071720 Oldham, J. M., Osepchook, C. C., Jeanplong, F., ..., Gerrard, D. F., et al. (2009). The decrease in mature myostatin protein in male skeletal muscle is developmentally regulated by growth hormone. Journal of Physiology, 587(3), 669-677. doi: 10.1113/jphysiol.2008.161521 Perez, D., Rudland, J. R., Wilson, H., Roberton, G., Gerrard, D., & Wheatley, A. (2009). The revised ‘Early Learning in Medicine’ curriculum at the University of Otago: Focusing on students, patients, and community. New Zealand Medical Journal, 122(1292). Retrieved from http://www.nzma.org.nz/journal/122-1292/3540/ Taylor, R. W., Murdoch, L., Carter, P., Gerrard, D. F., Williams, S. M., & Taylor, B. J. (2009). Longitudinal study of physical activity and inactivity in preschoolers: The FLAME study. Medicine and Science in Sports and Exercise, 41(1), 96-102.

Dunedin School of Medicine Department of General Practice

Chapter in Book - Research MacLeod, R., & Egan, T. (2009). Transformative palliative care education. In J. Mezirow & E. W. Taylor (Eds.), Transformative learning in practice: Insights from community, workplace, and higher education (pp. 111-121). San Francisco, CA: Jossey- Bass.

Journal - Research Article Blattner, K., Nixon, G., Dovey, S., Jaye, C., & Wigglesworth, J. (2010). Changes in clinical practice and patient disposition following the introduction of point-of-care testing in a rural hospital. Health Policy, 96, 7-12. doi: 10.1016/j. healthpol.2009.12.002 Blattner, K., Nixon, G., Jaye, C., & Dovey, S. (2010). Introducing point-of-care testing into a rural hospital setting: Thematic analysis of interviews with providers. Journal of Primary Health Care, 2(1), 54-60. Buetow, S., Kiata, L., Liew, T., Kenealy, T., Dovey, S., & Elwyn, G. (2009). Patient error: A preliminary taxonomy. Annals of Family Medicine, 7(3), 223-231. doi: 10.1370/afm.941 Buetow, S., Kiata, L., Liew, T., Kenealy, T., Dovey, S., & Elwyn, G. (2010). Approaches to reducing the most important patient errors in primary health-care: Patient and professional perspectives. Health & Social Care in the Community, 18(3), 296- 303. doi: 10.1111/j.1365-2524.2009.00904.x Cunningham, W., & Cookson, T. (2009). Addressing stress related impairment in doctors: A survey of providers’ and doctors’ experience of a funded counselling service in New Zealand. New Zealand Medical Journal, 122(1300). Retrieved from http://www.nzma.org.nz/journal/122-1300/3727/ Dovey, S., Tilyard, M., Cunningham, W., & Williamson, M. (2010). Public and private funding of general practice services for children and adolescents in New Zealand. Health Policy, Advance Online Publication. doi: 10.1016/j.healthpol.2010.09.003 Egnew, T. R., & Wilson, H. J. (2010). Faculty and medical students’ perceptions of teaching and learning about the doctor- patient relationship. Patient Education and Counseling, 79, 199-206. doi: 10.1016/j.pec.2009.08.012 Farry, P., Adams, J., Walters, L., Worley, P., & Dovey, S. (2010). Development of the Rural Immersion Programme for 5th-year medical students at the University of Otago. New Zealand Medical Journal, 123(1323). Retrieved from http://www.nzma. org.nz/journal/123-1323/4356/ Jaye, C., Egan, T., & Smith-Han, K. (2010). Communities of clinical practice and normalising technologies of self: Learning to fit in on the surgical ward. Anthropology & Medicine, 17(1), 59-73. doi: 10.1080/13648470903569388 Jaye, C., Egan, T., Smith-Han, K., & Thompson-Fawcett, M. (2009). Teaching and learning in the hospital ward. New Zealand Medical Journal, 122(1304). Retrieved from http://www.nzma.org.nz/journal/archive.shtml Jaye, C., & Fitzgerald, R. (2010). Embodying occupational overuse syndrome. Health, Advance Online Publication. doi: 10.1177/1363459310376298 Jaye, C., & Fitzgerald, R. (2010). The lived political economy of occupational overuse syndrome among New Zealand workers. Sociology of Health & Illness, 32(7), 1010-1025. doi: 10.1111/j.1467-9566.2010.01259.x Lau, Y., & Jaye, C. (2009). The ‘obligation’ to screen and its effect on autonomy. Journal of Bioethical Inquiry, 6(4), 495-505. doi: 10.1007/s11673-009-9188-8 Leitch, S., & Dovey, S. (2010). Review of registration requirements for new part-time doctors in New Zealand, Australia, the United Kingdom, Ireland and Canada. Journal of Primary Health Care, 2(4), 273-280.

146 RESEARCH REPORT 2009/2010 Liberty, K. A., Pattemore, P., Reid, J., & Tarren-Sweeney, M. (2010). Beginning school with asthma independently predicts low achievement in a prospective cohort of children. Chest, 138(6), 1349-1355. doi: 10.1378/chest.10-0543 McKechnie, R., MacLeod, R., & Jaye, C. (2010). Palliative care for people with non-malignant conditions in a New Zealand community. Progress in Palliative Care, 18(5), 275-280. doi: 10.1179/096992610X12775428636863 Perez, D., Rudland, J. R., Wilson, H., Roberton, G., Gerrard, D., & Wheatley, A. (2009). The revised ‘Early Learning in Medicine’ curriculum at the University of Otago: Focusing on students, patients, and community. New Zealand Medical Journal, 122(1292). Retrieved from http://www.nzma.org.nz/journal/122-1292/3540/ Plumridge, E., Goodyear-Smith, F., & Ross, J. (2009). Nurse and parent partnership during children’s vaccinations: A conversation analysis. Journal of Advanced Nursing, 65(6), 1187-1194. doi: 10.1111/j.1365-2648.2009.04999.x Runciman, W. B., Baker, G. R., Michael, P., Dovey, S., Lilford, R. J., Jensen, N., et al. (2010). Tracing the foundations of a conceptual framework for a patient safety ontology. Quality and Safety in Health Care, Advance Online Publication. doi: 10.1136/qshc.2009.035147 Selak, V., Rafter, N., Parag, V., Tomlin, A., Vander Hoorn, S., Dovey, S., & Rodgers, A. (2009). Cardiovascular treatment gaps: Closing, but slowly. New Zealand Medical Journal, 122(1293). Retrieved from http://www.nzma.org.nz/ journal/122-1293/3565/ Slaughter, R. J., Beasley, D. M. G., Lambie, B. S., & Schep, L. J. (2009). New Zealand’s venomous creatures. New Zealand Medical Journal, 122(1290). Retrieved from http://www.nzma.org.nz/journal/122-1290/3494/ Taylor, R. W., Brown, D., ..., Rose, E. A., Taylor, B. J., Meredith-Jones, K., Treacy, L., Ross, J., & Williams, S. M. (2010). Motivational interviewing for screening and feedback and encouraging lifestyle changes to reduce relative weight in 4-8 year old children: Design of the MInT study. BMC Public Health, 10, 271. doi: 10.1186/1471-2458-10-271 Williamson, M., Gormley, A., Dovey, S., & Farry, P. (2010). Rural hospitals in New Zealand: Results from a survey. New Zealand Medical Journal, 123(1315). Retrieved from http://www.nzma.org.nz/journal/archive.shtml

Journal - Research Other Bagg, W., ..., Reid, J. J., Rudland, J., Tweed, M. J., & Wilkinson, T. J. (2010). Setting up new learning environments in regional and rural areas. New Zealand Medical Journal, 123(1312). Retrieved from http://www.nzma.org.nz/journal/123-1312/4061/ Egan, T., & Jaye, C. (2009). Communities of clinical practice: The social organization of clinical learning. Health, 13(1), 107- 125. doi: 10.1177/1363459308097363 Reid, J. (2009). Hypertension and advice from natural health food stores [Editorial]. New Zealand Medical Journal, 122(1293). Retrieved from http://www.nzma.org.nz/journal/122-1293/3563/ Storr, E. (2009). View from the edge [Essay]. Journal of Primary Health Care, 1(2), 155-156. Sweet, G. S., & Wilson, H. J. (2010). A patient’s experience of ward rounds [Reflective practice]. Patient Education and Counseling, Advance Online Publication. doi: 10.1016/j.pec.2010.08.016 Wearn, A., Wilson, H., Hawken, S. J., Child, S., & Mitchell, C. J. (2010). In search of professionalism: Implications for medical education. New Zealand Medical Journal, 123(1314). Retrieved from http://www.nzma.org.nz/journal/123-1314/4116/ content.pdf

Journal - Professional & Other Non-Research Articles Reid, J. (2009). Sore throat in New Zealand [Editorial]. New Zealand Medical Journal, 122(1301). Retrieved from http://www. nzma.org.nz/journal/122-1301/ Reid, J. (2010). [Review of the book Mosby’s dictionary of medicine, nursing, and health professions: 2nd Australian and New Zealand edition]. New Zealand Medical Journal, 123(1320). Retrieved from http://www.nzma.org.nz/ journal/123-1320/4283/content.pdf Reid, J. (2010). [Review of the book The complete nMRCGP study guide (3rd edition)]. New Zealand Medical Journal, 123(1320). Retrieved from http://www.nzma.org.nz/journal/123-1320/4277/content.pdf Wallis, K. (2009). Uncertainty, fear and whistling happy tunes. Journal of Primary Health Care, 1(1), 71-73.

Commissioned Report for External Body Dowell, A. C., Garrett, S., Collings, S., McBain, L., McKinlay, E., & Stanley, J. (2009). Evaluation of the Primary Mental Health Initiatives: Summary report. Wellington, New Zealand: University of Otago and the Ministry of Health, 80p. Makeham, M., Dovey, S., Runciman, W., & Larizgoitia, I. (2009). Methods and measures used in primary care patient safety research: Results of a literature review. Commissioned by World Health Organization. WHO, 49p.

Working Paper; Discussion Paper; Technical Report Egan, R., McKechnie, R., Jopson, J., Herbison, P., & Richards, R. (2010). Factors influencing referrals to cancer support services in New Zealand. Dunedin, New Zealand: CSNZ Social & Behavioural Research Unit, University of Otago. (pp. 1-74).

Division of HEALTH SCIENCES 147 Dunedin School of Medicine Anaesthesia and Intensive Care Section

Journal - Research Article Endre, Z. H., Walker, R. J., Pickering, J. W., Shaw, G. M., Frampton, C. M., Henderson, S. J., Hutchinson, R., Mehrtens, J. E., Robinson, J. M., Schollum, J. B. W., Westhuyzen, J., Celi, L. A., McGinley, R. J., Campbell, I. J., & George, P. M. (2010). Early intervention with erythropoietin does not affect the outcome of acute kidney injury (the EARLYARF trial). Kidney International, 77, 1020-1030. doi: 10.1038/ki.2010.25 Galvin, S. D., Celi, L. A., Thomas, K. N., Clendon, T. R., Galvin, I. F., Bunton, R. W., & Ainslie, P. N. (2010). Effects of age and coronary artery disease on cerebrovascular reactivity to carbon dioxide in humans. Anaesthesia and Intensive Care, 38(4), 710-717. Reith, D., Medlicott, N. J., Kumara De Silva, R., Yang, L., Hickling, J., & Zacharias, M. (2009). Simultaneous modelling of the Michaelis-Menten kinetics of paracetamol sulphation and glucuronidation. Clinical and Experimental Pharmacology and Physiology, 36(1), 35-42. doi: 10.1111/j.1440-1681.2008.05029.x

Dunedin School of Medicine Bioethics Centre

Authored Book - Research Gillett, G. (2009). The mind and its discontent (2nd ed.). Oxford University Press, 432p. Jones, D. G., & Whitaker, M. I. (2009). Speaking for the dead: The human body in biology and medicine (2nd ed.). Farnham, UK: Ashgate, 296p.

Edited Book - Research Elford, R. J., & Jones, D. G. (Eds.). (2009). A tangled web: Medicine and theology in dialogue (Vol. 1). Oxford, UK: Peter Lang, 288p. Jones, D. G., & Elford, R. J. (Eds.). (2010). A glass darkly: Medicine and theology in further dialogue. Bern, Switzerland: Peter Lang, 246p. Nie, J-B., Guo, N., Selden, M., & Kleinman, A. (Eds.). (2010). Japan’s wartime medical atrocities: Comparative inquiries in science, history, and ethics. London and New York: Routledge, 254p.

Chapter in Book - Research Evans, D. (2009). Article 5: Autonomy and individual responsibility. In H. A. M. J. ten Have & M. S. Jean (Eds.), The UNESCO Universal Declaration on Bioethics and Human Rights: Background, principles and application (pp. 111-122). Paris: UNESCO. Evans, D. (2009). Autonomie et responsabilite individuelle [French translation of Article 5: Autonomy and individual responsibility]. In H. A. M. J. ten Have & M. S. Jean (Eds.), UNESCO: la Déclaration universelle sur la bioéthique et les droits de l’homme: Histoire, principes et application [French translation of the UNESCO Universal Declaration on Bioethics and Human Rights] . Paris: UNESCO. Gillett, G. (2010). Intentional action, moral responsibility and psychopaths. In L. Malatesti & J. McMillan (Eds.), Responsibility and psychopathy: Interfacing law, psychiatry and philosophy . New York: Oxford University Press. Guo, N., & Nie, J-B. (2010). Annotated bibliography: Primary sources and secondary literature in Japanese, Chinese and English. In J-B. Nie, N. Guo, M. Selden, & A. Kleinman (Eds.), Japan’s wartime medical atrocities: Comparative inquiries in science, history, and ethics (pp. 205-231). London and New York: Routledge. Harrigan, M., & Gillett, G. (2009). Hunting good will in the wilderness. In D. O’Connor & B. Purves (Eds.), Decision-making, personhood and dementia: Exploring the interface (pp. 47-57). London: Jessica Kingsley. Jones, D. G. (2009). Enhancement: Is baseless speculation misleading theologians and bioethicists? In R. J. Elford & D. G. Jones (Eds.), A tangled web: Medicine and theology in dialogue (pp. 123-142). Oxford, UK: Peter Lang. Jones, D. G. (2009). Introduction. In R. J. Elford & D. G. Jones (Eds.), A tangled web: Medicine and theology in dialogue (pp. 9-16). Oxford, UK: Peter Lang. Jones, D. G. (2009). Is PGD a form of eugenics? In R. J. Elford & D. G. Jones (Eds.), A tangled web: Medicine and theology in dialogue (pp. 143-161). Oxford, UK: Peter Lang. Jones, D. G. (2009). Regulatory procedures. In R. J. Elford & D. G. Jones (Eds.), A tangled web: Medicine and theology in dialogue (pp. 201-219). Oxford, UK: Peter Lang. Jones, D. G. (2009). The human body: An anatomist’s journey from death to life. In R. J. Elford & D. G. Jones (Eds.), A tangled web: Medicine and theology in dialogue (pp. 105-121). Oxford, UK: Peter Lang. Jones, D. G. (2010). Conclusion: The necessity of dialogue. In D. G. Jones & R. J. Elford (Eds.), A glass darkly: Medicine and theology in further dialogue (pp. 211-238). Bern, Switzerland: Peter Lang. Jones, D. G. (2010). The biomedical technologies: Prospects and challenges. In D. G. Jones & R. J. Elford (Eds.), A glass darkly: Medicine and theology in further dialogue (pp. 9-32). Bern, Switzerland: Peter Lang. Jones, D. G., & Whitaker, M. I. (2009). In vitro fertilization and the embryonic revolution. In R. Luppicini & R. Adell (Eds.), Handbook of research on technoethics (Vol. II) (pp. 609-622). Hersey, PA: Information Science Reference.

148 RESEARCH REPORT 2009/2010 Jones, D. G., & Whitaker, M. I. (2009). Scientific fraud: The demise of idealistic science. In R. J. Elford & D. G. Jones (Eds.), A tangled web: Medicine and theology in dialogue (pp. 89-104). Oxford, UK: Peter Lang. Kleinman, A., Nie, J-B., & Selden, M. (2010). Introduction: Medical atrocities, history and ethics. In J-B. Nie, N. Guo, M. Selden, & A. Kleinman (Eds.), Japan’s wartime medical atrocities: Comparative inquiries in science, history, and ethics (pp. 1-20). London and New York: Routledge. Nie, J-B. (2009). Medical ethics through the life cycle in China. In R. B. Baker & L. B. McCullough (Eds.), The Cambridge world history of medical ethics (pp. 126-131). Cambridge University Press. Nie, J-B. (2009). Radical disagreements of Chinese views on fetal life and implications for bioethics. In K-T. Ip (Ed.), The bioethics of regenerative medicine (pp. 63-73). New York: Springer. Nie, J-B. (2009). The discourses of practitioners in China. In R. B. Baker & L. B. McCullough (Eds.), The Cambridge world history of medical ethics (pp. 335-344). Cambridge University Press. Nie, J-B. (2010). China’s birth control program through feminist lenses. In J. L. Scully, L. E. Baldwin-Ragaven, & P. Fitzpatrick (Eds.), Feminist bioethics: At the center, on the margins (pp. 257-277). Baltimore, MD: Johns Hopkins University Press. Nie, J-B. (2010). On the alter of nationalism and the nation-state: Japan’s wartime medical atrocities, the American cover-up, and postwar Chinese responses. In J-B. Nie, N. Guo, M. Selden, & A. Kleinman (Eds.), Japan’s wartime medical atrocities: Comparative inquiries in science, history, and ethics (pp. 123-138). London and New York: Routledge. Nie, J-B., Tsuchiya, T., & Li, L. (2009). Japanese doctors’ experimentation, 1932-1945, and medical ethics. In R. B. Baker & L. B. McCullough (Eds.), The Cambridge world history of medical ethics (pp. 589-594). Cambridge University Press.

Chapter in Book - Other Anderson, L., & Ellis, E. (2009). Ethics, practice regulation and physiotherapy. In J. Higgs, M. Smith, G. Webb, M. Skinner, & A. Croker (Eds.), Contexts of physiotherapy practice (pp. 177-188). Sydney, Australia: Churchill Livingstone. Anderson, L., & Pelvin, B. (2010). Ethical frameworks for practice. In S. Pairman, S. Tracy, C. Thorogood, & J. Pincombe (Eds.), Midwifery: Preparation for practice (2nd ed.). (pp. 283-297). Chatswood, Australia: Elsevier. Jones, G. (2009). Borderlands. In R. J. Berry (Ed.), Real scientists: Real faith (pp. 58-71). Oxford, UK: Monarch Books.

Journal - Research Article Anderson, L. C. (2009). Writing a new code of ethics for sports physicians: Principles and challenges. British Journal of Sports Medicine. doi: 10.1136/bjsm.2008.051086 Anderson, L. C., & Pickering, N. J. (2010). The student code: Ethical and professional expectations of medical students at the University of Otago. New Zealand Medical Journal, 123(1318). Retrieved from http://www.nzma.org.nz/ journal/123-1318/4216/ Collyns, O., Gillett, G., & Darlow, B. (2009). Overlap of premature birth and permissible abortion. Journal of Medical Ethics, 35(6), 343-347. doi: 10.1136/jme.2008.028928 Gillett, G. (2009). Indigenous knowledges: Circumspection, metaphysics, and scientific ontologies. Sites, 6(1), 97-115. Gillett, G. (2009). Intention, autonomy, and brain events. Bioethics, 23(6), 330-339. doi: 10.1111/j.1467-8519.2009.01726.x Gillett, G. (2009). The evolution of the human soul. Colloquium, 41(2), 165-180. Gillett, G. (2009). The layering of the psyche: Philosophy, psychiatry, and difference. Journal of Mind and Behavior, 30(4), 205-228. Gillett, G. R. (2009). The subjective brain, identity, and neuroethics. American Journal of Bioethics, 9(9), 5-13. doi: 10.1080/15265160903090058 Gillett, G. R., Honeybul, S., Ho, K. M., & Lind, C. R. P. (2010). Neurotrauma and the RUB: Where tragedy meets ethics and science. Journal of Medical Ethics, 36, 727-730. doi: 10.1136/jme.2010.037424 Gillett, G., & Saville-Cook, D. (2010). Too much information? Journal of Primary Health Care, 2(2), 165-167. Harland, T., Tidswell, T., Everett, D., Hale, L., & Pickering, N. (2010). Neoliberalism and the academic as critic and conscience of society. Teaching in Higher Education, 15(1), 85-96. doi: 10.1080/13562510903487917 Honeybul, S., Ho, K. M., Lind, C. R. P., Corcoran, T., & Gillett, G. R. (2009). The retrospective application of a prediction model to patients who have had a decompressive craniectomy for trauma. Journal of Neurotrauma, 26(12), 2179-2183. doi: 10.1089/neu.2009.0989 Honeybul, S., Ho, K. M., Lind, C. R. P., & Gillett, G. R. (2010). Decompressive craniectomy for neurotrauma: The limitations of applying an outcome prediction model. Acta Neurochirurgica, Advance Online Publication. doi: 10.1007/s00701-010- 0626-5 Honeybul, S., Ho, K. M., Lind, C. R. P., & Gillett, G. R. (2010). Observed versus predicted outcome for decompressive craniectomy: A population-based study. Journal of Neurotrauma, 27(7), 1225-1232. doi: 10.1089/neu.2010.1316 Jones, D. G. (2009). Gauging public opinion towards the reproductive technologies. Kötuitui, 4, 221-224. Retrieved from http://www.royalsociety.org.nz/Site/publish/Journals/kotuitui/default.aspx Jones, D. G. (2010). Peering into people’s brains: Neuroscience’s intrusion into our inner sanctum. Perspectives on Science & Christian Faith, 62(2), 122-132. Jones, D. G., King, M. R., & Whitaker, M. I. (2009). Who gets born? How did New Zealand’s Bioethics Council arrive at its recommendations? [Viewpoint]. New Zealand Medical Journal, 122(1294). Retrieved from http://www.nzma.org.nz/ journal/122-1294/3585/ Jones, D. G., & Whitaker, M. I. (2009). Engaging with plastination and the Body Worlds phenomenon: A cultural and intellectual challenge for anatomists. Clinical Anatomy, 22(6), 770-776. doi: 10.1002/ca.20824

Division of HEALTH SCIENCES 149 Jones, D. G., & Whitaker, M. I. (2009). Finding a context for discussing human life-extension. American Journal of Bioethics, 9(12), 77-79. doi: 10.1080/15265160903318376 Lau, Y., & Jaye, C. (2009). The ‘obligation’ to screen and its effect on autonomy. Journal of Bioethical Inquiry, 6(4), 495-505. doi: 10.1007/s11673-009-9188-8 Nie, J-B. (2010). Limits of state intervention in sex-selective abortion: The case of China. Culture, Health & Sexuality, 12(2), 205-219. doi: 10.1080/13691050903108431 Pickering, N. (2010). Who’s a quack? Bioethical Inquiry, 7(1), 43-52. doi: 10.1007/s11673-010-9211-0 Walsh, B. H. (2010). The spatialisation of disease: Foucualt and Evidence-based Medicine (EBM). Journal of Bioethical Inquiry, 7, 31-42. doi: 10.1007/s11673-010-9216-8.

Journal - Research Other Evans, D. M. (2009). [Response to Republication: In that case]. Journal of Bioethical Inquiry, 6(1), 145-146. doi: 10.1007/ s11673-008-9128-z Evans, K. L., & Steslow, K. (2010). [Review of the book A rest from reason: Wittgenstein, Drury, and the difference between madness and religion]. Philosophy, 85(332), 245-258. doi: 10.1017/s0031819110000070 Gillett, G. (2009). When two are born as one: The ethics of separating conjoined twins. Journal of Law and Medicine, 17(2), 184-189. Gillett, G. (2009). Whose best interests? Advance directives and clinical discretion. Journal of Law and Medicine, 16(5), 751- 758. Gillett, G. (2010). [Response to In that case: Transformations]. Journal of Bioethical Inquiry, 7, 271-272. doi: 10.1007/s11673- 010-9232-8 Gillett, G. (2010). Problematizing biomedicine. Journal of Bioethical Inquiry, 7(1), 9-12. doi: 10.1007/s11673-010-9217-7 Gillett, G. (2010). The multiaxial, multi-layered reality that is mental disorder. Association for the Advancement of Philosophy and Psychiatry Bulletin, 17(1), 5-7. Gillett, G. R. (2009). Responses to open peer commentaries on ²The subjective brain, identity, and neuroethics². American Journal of Bioethics, 9(9), W1-W4. doi: Gillett, G., & Saville-Cook, D. (2010). Regulation of biomedical products. Journal of Law and Medicine, 17(5), 701-707. Jones, D. G., & Whitaker, M. I. (2009). Religious traditions and embryo science [Commentary]. American Journal of Bioethics, 9(11), 41-43. doi: 10.1080/15265160903197697 Jones, D. G., & Whitaker, M. I. (2010). Cadavers, plastinates, and mummies [Letter to the editor]. Clinical Anatomy, 23(1), 125- 126. doi: 10.1002/ca.20894 Pickering, N. (2009). Absence of significant dissent should be sufficient for deceased organ procurement in New Zealand [Commentary]. Australian and New Zealand Journal of Public Health, 33(5), 454-456. doi: 10.1111/j.1753- 6405.2009.00428.x

Journal - Professional & Other Non-Research Articles Gillett, G. (2009). [Review of the books The moral demands of memory and Talking cures and placebo effects]. Journal of Applied Philosophy, 26(4), 420-422. doi: 10.1111/j.1468-5930.2009.00464.x Jones, D. G. (2009). [Review of the book Sacred cells? Why Christians should support stem cell research]. Perspectives on Science and Christian Faith, 61(4), 261-262. Jones, D. G. (2009). [Review of the book The big questions in science and religion]. Theological Book Review, 21(2), 10. Jones, D. G. (2009). [Review of the book The cell’s design: How chemistry reveals the Creator’s artistry]. Theological Book Review, 21(1), 14-15. Jones, D. G. (2009). [Review of the book The sanctity of human life]. Theological Book Review, 21(2), 93-94. Jones, G. (2010). Heavenly bodies: The future of surgical enhancement. Third Way, (September), 13. Pickering, N. (2010). Inducements, autonomy and justice. HRC Ethics Notes, (April), 1-3. Retrieved from http://www.hrc.govt. nz/assets/pdfs/publications/Ethics%20Notes%20Mar10.pdf

Dunedin School of Medicine Medicine Section

Journal - Research Article Abbott, J. H., Robertson, M. C., McKenzie, J. E., Baxter, G. D., Theis, J-C., Campbell, A. J., & the MOA Trial Team (2009). Exercise therapy, manual therapy, or both, for osteoarthritis of the hip or knee: A factorial randomised controlled trial protocol. Trials, 10(11). doi: 10.1186/1745-6215-10-11 Ahmadi, O., de L Nicholson, M., Gould, M. L., Mitchell, A., & Stringer, M. D. (2010). Interstitial cells of Cajal are present in human extrahepatic bile ducts. Journal of Gastroenterology and Hepatology, 25(2), 277-285. doi: 10.1111/j.1440- 1746.2009.05980.x Avouac, J., Walker, U., Tyndall, A., Kahan, A., Matucci-Cerrinic, M., Allanore, Y., EUSTAR, including Stebbings, S., & Stamp, L. (2010). Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis: Results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database. Journal of Rheumatology, 37(7), 1488-1501. doi: 10.3899/jrheum.091165

150 RESEARCH REPORT 2009/2010 Barnes, P. J., Dweik, R. A., Gelb, A. F., ..., Silkoff, P. E., Taylor, D. R., & Zamel, N. (2010). Exhaled nitric oxide in pulmonary diseases: A comprehensive review. Chest, 138(3), 682-692. doi: 10.1378/chest.09-2090 Bird, S. D., Walker, R. J., & Legge, M. (2009). l-Cysteine improves survival and growth of mesothelial cells after freezing. Cell Biology International, 33(11), 1155-1164. doi: 10.1016/j.cellbi.2009.08.003 Bracewell, L. M., Campbell, D. I., Faure, P. R., Giblin, E. R., Morris, T. A., Satterthwaite, L. B., Simmers, C. D. A., Ulrich, C. M., & Holmes, J. D. (2010). Sickness presenteeism in a New Zealand hospital. New Zealand Medical Journal, 123(1314). Retrieved from http://www.nzmj.org/journal/123-1314/ Buchner, D. M., & Campbell, A. J. (2010). Inactivity as a risk factor for activity-related injuries. American Journal of Preventive Medicine, 39(1), 102-103. doi: 10.1016/j.amepre.2010.04.001 Cameron, I. D., Murray, G. R., Gillespie, L. D., Robertson, M. C., Hill, K. D., Cumming, R. G., & Kerse, N. (2010). Interventions for preventing falls in older people in nursing care facilities and hospitals. Cochrane Database of Systematic Reviews, (1), CD005465. doi: 10.1002/14651858.CD005465.pub2 Campbell, A. J., & Robertson, M. C. (2010). Comprehensive approach to fall prevention on a national level: New Z79ealand. Clinics in Geriatric Medicine, 26(4), 719-731. doi: 10.1016/j.cger.2010.06.004 Chang, A. Y., Marsh, S., Smith, N., & Neill, A. (2010). Long-term community non-invasive ventilation. Internal Medicine Journal, 40(11), 764-771. doi: 10.1111/j.1445-5994.2010.02171.x Chase, J. G., Andreassen, S., Pielmeier, U., Hann, C. E., McAuley, K. A., & Mann, J. I. (2009). A glucose-insulin pharmacodynamic surface modeling validation and comparison of metabolic system models. Biomedical Signal Processing and Control, 4(4), 355-363. doi: 10.1016/j.bspc.2009.04.002 Chase, J. G., Mayntzhusen, K., Docherty, P. D., Andreassen, S., McAuley, K. A., Lotz, T. F., & Hann, C. E. (2010). A three- compartment model of the C-peptide-insulin dynamic during the DIST test. Mathematical Biosciences, Advance Online Publication. doi: 10.1016/j.mbs.2010.09.001 Chua, S., Levine, R. A., Yosefy, C., Handschumacher, M. D., Chu, J., Qureshi, A., et al. (2009). Assessment of right ventricular function by real-time three-dimensional echocardiography improves accuracy and decreases interobserver variability compared with conventional two-dimensional views. European Journal of Echocardiography, 10(5), 619-624. doi: 10.1093/ ejechocard/jep013 Chu, J. W., Wong, C-K., Chambers, J., Vant Wout, J., Herbison, P., & Tang, E. W. (2010). Aspirin resistance determined from a bed-side test in patients suspected to have acute coronary syndrome portends a worse 6 months outcome. QJM, 103, 405- 412. doi: 10.1093/qjmed/hcq038 Clark-Grill, M. (2010). When listening to the people: Lessons from complementary and alternative medicine (CAM) for bioethics. Journal of Bioethical Inquiry, 7, 71-81. doi: 10.1007/s11673-010-9218-6 Coppell, K. J., Anderson, K., Williams, S. M., Lamb, C., Farmer, V. L., & Mann, J. I. (2010). The quality of diabetes care: A comparison between patients enrolled and not enrolled on a regional diabetes register. Primary Care Diabetes, Advance Online Publication. doi: 10.1016/j.pcd.2010.10.005 Coppell, K. J., Kataoka, M., Williams, S. M., Chisholm, A. W., Vorgers, S. M., & Mann, J. I. (2010). Nutritional intervention in patients with type 2 diabetes who are hyperglycaemic despite optimised drug treatment: Lifestyle over and above drugs in diabetes (LOADD) study: Randomised controlled trial. BMJ, 341, c3337. doi: 10.1136/bmj.c3337 Coppell, K. J., Tipene-Leach, D. C., Pahau, H. L. R., Williams, S. M., Abel, S., Iles, M., Harre Hindmarsh, J., & Mann, J. I. (2009). Two-year results from a community-wide diabetes prevention intervention in a high risk indigenous community: The Ngati and Healthy Project. Diabetes Research and Clinical Practice, 85(2), 220-227. doi: 10.1016/j.diabres.2009.05.009 Cowan, D. C., Cowan, J. O., Palmay, R. D., Williamson, A., & Taylor, D. R. (2010). The effects of steroid therapy on inflammatory cell subtypes in asthma. Thorax, 65, 384-390. doi: 10.1136/thx.2009.126722 Cowan, D. C., Cowan, J. O., Palmay, R., Williamson, A., & Taylor, D. R. (2010). Effects of steroid therapy on inflammatory cell subtypes in asthma. Thorax, 65(5), 384-390. doi: 10.1136/thx.2009.126722 Cowan, D. C., Cowan, J. O., Palmay, R., Williamson, A., & Taylor, D. R. (2010). Simvastatin in the treatment of asthma: Lack of steroid-sparing effect. Thorax, 65(10), 891-896. doi: 10.1136/thx.2010.138990 Cowan, D. C., Hewitt, R. S., Cowan, J. O., Palmay, R., Williamson, A., Lucas, S. J. E., Murrell, C. J., Thomas, K. N., & Taylor, D. R. (2010). Exercise-induced wheeze: Fraction of exhaled nitric oxide-directed management. Respirology, 15, 683-690. doi: 10.1111/j.1440-1843.2010.01740.x Dale, K. S., Mann, J. I., McAuley, K. A., Williams, S. M., & Farmer, V. L. (2009). Sustainability of lifestyle changes following an intensive lifestyle intervention in insulin resistant adults: Follow-up at 2-years. Asia Pacific Journal of Clinical Nutrition, 18(1), 114-120. Dale, K. S., McAuley, K. A., Taylor, R. W., Williams, S. M., Farmer, V. L., Hansen, P., Vorgers, S. M., Chisholm, A. W., & Mann, J. I. (2009). Determining optimal approaches for weight maintenance: A randomized controlled trial. CMAJ, 180(10), E39-E46. doi: 10.1503/cmaj.080974 Davis, J. C., Marra, C. A., Robertson, M. C., Khan, K. M., Najafzadeh, M., Ashe, M., & Liu-Ambrose, T. (2010). Economic evaluation of dose-response resistance training in older women: A cost-effectiveness and cost-utility analysis. Osteoporosis International, Advance Online Publication. doi: 10.1007/s00198-010-1356-5 Davis, J. C., Robertson, M. C., Ashe, M. C., Liu-Ambrose, T., Khan, K. M., & Marra, C. A. (2010). Does a home-based strength and balance programme in people aged ³80 years provide the best value for money to prevent falls? A systematic review of economic evaluations of falls prevention interventions. British Journal of Sports Medicine, 44(2), 80-89. doi: 10.1136/ bjsm.2008.060988

Division of HEALTH SCIENCES 151 Davis, J. C., Robertson, M. C., Ashe, M. C., Liu-Ambrose, T., Khan, K. M., & Marra, C. A. (2010). International comparison of cost of falls in older adults living in the community: A systematic review. Osteoporosis International, 21, 1295-1306. doi: 10.1007/s00198-009-1162-0 Derraik, J. G. B., Slaney, D. P., Nye, E. R., & Weinstein, P. (2010). Chikungunya virus: A novel and potentially serious threat to New Zealand and the South Pacific Islands. American Journal of Tropical Medicine and Hygiene, 83(4), 755-759. doi: 10.4269/ajtmh.2010.10-0123 Derrett, S., Darmody, M., Williams, S., Rutherford, M., Schollum, J., & Walker, R. (2010). Older peoples’ satisfaction with home-based dialysis. Nephrology, 15(4), 464-470. doi: 10.1111/j.1440-1797.2010.01286.x Docherty, P. D., Chase, J. G., Lotz, T. F., Hann, C. E., Shaw, G. M., Berkeley, J. E., TeMorenga, L., Mann, J. I., & McAuley, K. (2010). Independent cohort cross-validation of the real-time DISTq estimation of insulin sensitivity. Computer Methods and Programs in Biomedicine, Advance Online Publication. doi: 10.1016/j.cmpb.2010.08.002 Dummer, J. F., Epton, M. J., Cowan, J. O., Cook, J. M., Condliffe, R., Landhuis, C. E., Smith, A. D., & Taylor, D. R. (2009). Predicting corticosteroid response in chronic obstructive pulmonary disease using exhaled nitric oxide. American Journal of Respiratory and Critical Care Medicine, 180(9), 846-852. doi: 10.1164/rccm.200905-0685OC Ellis, C., Devlin, G., Elliott, J., Matsis, P., Williams, M., Gamble, G., Hamer, A., Richards, M., et al. (2010). ACS patients in New Zealand experience significant delays to access cardiac investigations and revascularisation treatment especially when admitted to non-interventional centres: Results of the second comprehensive national audit of ACS patients. New Zealand Medical Journal, 123(1319). Retrieved from http://www.nzma.org.nz/journal/archive.php Endre, Z. H., Walker, R. J., Pickering, J. W., Shaw, G. M., Frampton, C. M., Henderson, S. J., Hutchinson, R., Mehrtens, J. E., Robinson, J. M., Schollum, J. B. W., Westhuyzen, J., Celi, L. A., McGinley, R. J., Campbell, I. J., & George, P. M. (2010). Early intervention with erythropoietin does not affect the outcome of acute kidney injury (the EARLYARF trial). Kidney International, 77, 1020-1030. doi: 10.1038/ki.2010.25 Fitches, A. C., Yousem, S., Cieply, K., Stebbings, S., Highton, J., & Hung, N. A. (2010). PCR detectable Y chromosome-specific DNA but no intact Y chromosome-bearing cells in polymyositis biopsies of two women with male offspring. Pathology, 42(2), 160-164. doi: 10.3109/00313020903494953 Galvin, S. D., Celi, L. A., Thomas, K. N., Clendon, T. R., Galvin, I. F., Bunton, R. W., & Ainslie, P. N. (2010). Effects of age and coronary artery disease on cerebrovascular reactivity to carbon dioxide in humans. Anaesthesia and Intensive Care, 38(4), 710-717. Garrett, J., Chen, B., & Taylor, D. R. (2009). A survey of respiratory and sleep services in New Zealand undertaken by the Thoracic Society of Australia and New Zealand (TSANZ). New Zealand Medical Journal, 122(1289). Retrieved from http:// www.nzma.org.nz/journal/122-1289/3456/ Gillespie, L. D., Robertson, M. C., Gillespie, W. J., Lamb, S. E., Gates, S., Cumming, R. G., & Rowe, B. H. (2009). Interventions for preventing falls in older people living in the community. Cochrane Database of Systematic Reviews, (2), CD007146. doi: 10.1002/14651858.CD007146.pub2 Gillett, W. R., & Jones, D. (2009). Chronic pelvic pain in women: Role of the nervous system. Expert Review of Obstetrics & Gynecology, 4(2), 149-163. doi: 10.1586/17474108.4.2.149 Girasis, C., Onuma, Y., Wong, C-K., Kukreja, N., van Domburg, R., & Serruys, P. (2009). Long-term outcome after the V stenting technique in de novo bifurcation lesions using drug-eluting stents. EuroIntervention, 5(2), 197-205. Goulding, A., Taylor, R. W., Grant, A. M., Jones, S., Taylor, B. J., & Williams, S. (2009). Relationships of appendicular LMI and total body LMI to bone mass and physical activity levels in a birth cohort of New Zealand five-year olds. Bone, 45, 455- 459. doi: 10.1016/j.bone.2009.05.007 Goulding, A., Taylor, R. W., Grant, A. M., Parnell, W. R., Wilson, N., Wilson, N. C., & Williams, S. M. (2010). Waist-to-height ratios in relation to BMI z-scores in three ethnic groups from a representative sample of New Zealand children aged 5-14 years. International Journal of Obesity, 34, 1188-1190. doi: 10.1038/ijo.2009.278 Gretarsdottir, S., Baas, A. F., Thorleifsson, G., Holm, H., den Heijer, M., de Vries, J-P. P. M., Kranendonk, S. E., Zeebregts, C. J. A. M., van Sterkenburg, S. M., Geelkerken, R. H., van Rij, A. M., Williams, M. J. A., ..., Jones, G. T., et al. (2010). Genome- wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm. Nature Genetics, Advance Online Publication. doi: 10.1038/ng.622 Gudbjartsson, D. F., Bjornsdottir, U. S., Halapi, E., ..., Williams, M. J. A., van Rij, A. M., Jones, G. T., et al. (2009). Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nature Genetics, 41(3), 342-347. doi: 10.1038/ng.323 Hale, L. A., Nukada, H., Du Plessis, L. J., & Peebles, K. C. (2009). Clinical screening of autonomic dysfunction in multiple sclerosis. Physiotherapy Research International, 14(1), 42-55. doi: 10.1002/pri.416 Hammond-Tooke, G. D., Goei, J., du Plessis, L. J., & Franz, E. A. (2010). Concussion causes transient dysfunction in cortical inhibitory networks but not the corpus callosum. Journal of Clinical Neuroscience, 17(3), 315-319. doi: 10.1016/j. jocn.2009.06.026 Hancox, R. J., Poulton, R., Ely, M., Welch, D., Taylor, D. R., McLachlan, C. R., Greene, J. M., Moffitt, T. E., Caspi, A., & Sears, M. R. (2010). Effects of cannabis on lung function: A population-based cohort study. European Respiratory Journal, 35(1), 42-47. doi: 10.1183/09031936.00065009 Hancox, R. J., Poulton, R., Greene, J. M., McLachlan, C. R., Pearce, M. S., & Sears, M. R. (2009). Associations between birth weight, early childhood weight gain and adult lung function. Thorax, 64(3), 228-232.

152 RESEARCH REPORT 2009/2010 Hancox, R. J., Poulton, R., Welch, D., Olova, N., McLachlan, C. R., Greene, J. M., Sears, M. R., Caspi, A., Moffitt, T. E., Robertson, S. P., & Braithwaite, A. W. (2009). Accelerated decline in lung function in cigarette smokers is associated with TP53/MDM2 polymorphisms. Human Genetics, 126(4), 559-565. doi: 10.1007/s00439-009-0704-z Han, H., Deng, X., Fong, A. H., & Zhang, M. (2010). Dural entrance of the bridging vein in the middle cranial fossa: A novel classification of the cerebral veins for preoperative planning. Neurosurgery, 67(3), 9-15. doi: 10.1227/01. neu.0000381683.27324.14 Harkins, C., Hammond-Tooke, G., & Faed, J. (2009). Intravenous immunoglobulin therapy for neurological disorders. New Zealand Medical Journal, 122(1305). Retrieved from http://www.nzma.org.nz/journal/122-1305/3850/ Hewitt, R. S., Modrich, C. M., Cowan, J. O., Herbison, G. P., & Taylor, D. R. (2009). Outcomes using exhaled nitric oxide measurements as an adjunct to primary care asthma management. Primary Care Respiratory Journal, 18(4), 320-327. doi: 10.4104/pcrj.2009.00060 Heydon, E. E., Thomson, C. D., Mann, J., Williams, S. M., Skeaff, S. A., Sherpa, K. T., & Heydon, J. L. (2009). Iodine status in a Sherpa community in a village of the Khumbu region of Nepal. Public Health Nutrition, 12(9), 1431-1436. Hollis-Moffatt, J. E., Chen-Xu, M., Topless, R., Dalbeth, N., Gow, P. J., Harrison, A. A., Highton, J., Jones, P. B. B., Nissen, M., Smith, M. D., van Rij, A., Jones, G. T., Stamp, L. K., & Merriman, T. R. (2010). Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: Confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance. Arthritis Research & Therapy, 12(3), R116. doi: 10.1186/ar3053 Hollis-Moffatt, J. E., Merriman, M. E., Rodger, R. A., Rowley, K. A., Chapman, P. T., Dalbeth, N., Gow, P. J., Harrison, A. A., Highton, J., Jones, P. B. B., O’Donnell, J. L., Stamp, L. K., & Merriman, T. R. (2009). Evidence for association of an interleukin 23 receptor variant independent of the R381Q variant with rheumatoid arthritis. Annals of the Rheumatic Diseases, 68(8), 1340-1344. doi: 10.1136/ard.2008.090142 Hollis-Moffatt, J. E., Rowley, K. A., Phipps-Green, A. J., Merriman, M. E., Dalbeth, N., Gow, P., Harrison, A. A., Highton, J., Jones, P. B. B., Stamp, L. K., Harrison, P., Wordsworth, B. P., & Merriman, T. R. (2009). The ITGAV rs3738919 variant and susceptibility to rheumatoid arthritis in four Caucasian sample sets. Arthritis Research & Therapy, 11, R152. doi: 10.1186/ ar2828 Hollis-Moffatt, J. E., Xu, X., Dalbeth, N., Merriman, M. E., Topless, R., Waddell, C., Gow, P. J., Harrison, A. A., Highton, J., Jones, P. B. B., Stamp, L. K., & Merriman, T. R. (2009). Role of the urate transporter SLC2A9 gene in susceptibility to gout in New Zealand Mäori, Pacific Island, and Caucasian case-control sample sets. Arthritis and Rheumatism, 60(11), 3485- 3492. doi: 10.1002/art.24938 Jackson, C., Sirohi, B., Cunningham, D., Horwich, A., Thomas, K., & Wotherspoon, A. (2010). Lymphocyte-predominant Hodgkin lymphoma-clinical features and treatment outcomes from a 30-year experience. Annals of Oncology, 21(10), 2061-2068. doi: 10.1093/annonc/mdq063 Jenks, K., Meikle, G., Gray, A., & Stebbings, S. (2009). Osteitis condensans ilii: A significant association with sacroiliac joint tenderness in women. International Journal of Rheumatic Diseases, 12(1), 39-43. doi: 10.1111/j.1756-185X.2009.01378.x Jenks, K., Stebbings, S., Burton, J., Schultz, M., Herbison, G. P., & Highton, J. (2010). Probiotic therapy for the treatment of spondyloarthritis: A randomized controlled trial. Journal of Rheumatology, Advance Online Publication. doi: 10.3899/ jrheum.100193 Jenks, K., Treharne, G. J., Garcia, J., & Stebbings, S. (2010). The Ankylosing Spondylitis Quality of Life Questionnaire: Validation in a New Zealand cohort. International Journal of Rheumatic Diseases, 13(4), 361-366. doi: 10.1111/j.1756- 185X.2010.01554.x Jones, G. T., Tarr, G. P., Phillips, L. V., Wilkins, G. T., van Rij, A. M., & Williams, M. J. A. (2009). Active matrix metalloproteinases 3 and 9 are independently associated with coronary artery in-stent restenosis. Atherosclerosis, 207(2), 603-607. doi: 10.1016/j.atherosclerosis.2009.05.036 Kanzaki, M., Tsuchihara, T., McMorran, D., Taylor, P., & Hammond-Tooke, G. D. (2010). A rat model of Urtica ferox neuropathy. Neurotoxicology, Advance Online Publication. doi: 10.1016/j.neuro.2010.07.004 Kazani, S., Ware, J. H., Drazen, J. M., Taylor, D. R., & Sears, M. R. (2010). The safety of long-acting beta-agonists: More evidence is needed: Pro/con debate. Respirology, 15(6), 881-886. doi: 10.1111/j.1440-1843.2010.01800.x Kostikas, K., Papaioannou, A. I., Tanou, K., ..., Taylor, D. R., et al. (2010). Exhaled NO and exhaled breath condensate pH in the evaluation of asthma control. Respiratory Medicine, Advance Online Publication. doi: 10.1016/j.rmed.2010.10.015 Langley, J., Samaranayaka, A., Davie, G., & Campbell, A. J. (2010). Age, cohort and period effects on hip fracture incidence: Analysis and predictions from New Zealand data 1974-2007. Osteoporosis International, Advance Online Publication. doi: 10.1007/s00198-010-1205-6 Lee, H. J., Waller, R. D., Stebbings, S., Highton, J., Orlovich, D. A., Schmierer, D., & Fawcett, J. P. (2010). The effects of an orally administered probiotic on sulfasalazine metabolism in individuals with rheumatoid arthritis: A preliminary study. International Journal of Rheumatic Diseases, 13(1), 48-54. doi: 10.1111/j.1756-185X.2009.01449.x MacDonald, J., Sohn, S., & Ellis, P. (2010). Privacy, professionalism and Facebook: A dilemma for young doctors. Medical Education, 44(8), 805-813. doi: 10.1111/j.1365-2923.2010.03720.x Mandhane, P. J., Sears, M. R., Poulton, R., Greene, J. M., Lou, W. Y. W., Taylor, D. R., & Hancox, R. J. (2009). Cats and dogs and the risk of atopy in childhood and adulthood. Journal of Allergy and Clinical Immunology, 124(4), 745-750. doi: 10.1016/j. jaci.2009.06.038 McAuley, K. A., Taylor, R. W., Farmer, V. L., Hansen, P., Williams, S. M., Booker, C. S., & Mann, J. I. (2010). Economic evaluation of a community-based obesity prevention program in children: The APPLE project. Obesity, 18(1), 131-136. doi: 10.1038/oby.2009.148

Division of HEALTH SCIENCES 153 McKelvey, K. J., Highton, J., & Hessian, P. A. (2010). Cell-specific expression of TLR9 isoforms in inflammation. Journal of Autoimmunity, Advance Online Publication. doi: 10.1016/j.jaut.2010.11.001 McKinney, C., Fanciulli, M., Merriman, M. E., Phipps-Green, A., ..., Harrison, A. A., Highton, J., Jones, P. B., Stamp, L. K., ..., & Merriman, T. R. (2010). Association of variation in Fcg receptor 3B gene copy number with rheumatoid arthritis in Caucasian samples. Annals of the Rheumatic Diseases, 69, 1711-1716. doi: 10.1136/ard.2009.123588 McLean, R., & Connor, J. (2009). Alcohol and injury: A survey in primary care settings. New Zealand Medical Journal, 122(1303). Retrieved from http://www.nzma.org.nz/journal/122-1303/3798/ McLean, R. M., Hoek, J. A., Buckley, S., ..., Johnston, M., Mann, J. I., et al. (2009). ²Healthy Eating - Healthy Action²: Evaluating New Zealand’s obesity prevention strategy. BMC Public Health, 9, 452. doi: 10.1186/1471-2458-9-452 Murrell, C. J., Cotter, J. D., George, K. P., Shave, R., Wilson, L. C., Thomas, K. N., Williams, M. J. A., Lowe, T., & Ainslie, P. N. (2009). Influence of age on syncope following prolonged exercise: Differential responses but similar orthostatic intolerance. Journal of Physiology, 587(24), 5959-5969. doi: 10.1113/jphysiol.2009.179549 Murrell, C. J., Cotter, J. D., George, K., Shave, R., Wilson, L., Thomas, K., Williams, M. J. A., & Ainslie, P. N. (2010). Cardiorespiratory and cerebrovascular responses to head-up tilt II: Influence of age, training status and acute exercise. Experimental Gerontology, Advance Online Publication. doi: 10.1016/j.exger.2010.06.004 Murrell, C. J., Cotter, J. D., George, K., Shave, R., Wilson, L., Thomas, K., Williams, M. J. A., & Ainslie, P. N. (2010). Cardiorespiratory and cerebrovascular responses to head-up tilt I: Influence of age and training status. Experimental Gerontology, Advance Online Publication. doi: 10.1016/j.exger.2010.06.005 Murrell, C. J., Cotter, J. D., George, K., Shave, R., Wilson, L., Thomas, K., Williams, M. J. A., & Ainslie, P. N. (2010). Syncope is unrelated to supine and postural hypotension following prolonged exercise. European Journal of Applied Physiology and Occupational Physiology, Advance Online Publication. doi: 10.1007/s00421-010-1671-8 Nejat, M., Pickering, J. W., Walker, R. J., & Endre, Z. H. (2010). Rapid detection of acute kidney injury by plasma cystatin C in the intensive care unit. Nephrology, Dialysis, Transplantation, 25, 3283-3289. doi: 10.1093/ndt/gfq176 Nejat, M., Pickering, J. W., Walker, R. J., Westhuyzen, J., Shaw, G. M., Frampton, C. M., & Endre, Z. H. (2010). Urinary cystatin C is diagnostic of acute kidney injury and sepsis, and predicts mortality in the intensive care unit. Critical Care, 14(3), R85. doi: 10.1186/cc9014 Nielsen, G., Taylor, R., Williams, S., & Mann, J. (2010). Permanent play facilities in school playgrounds as a determinant of children’s activity. Journal of Physical Activity and Health, 7(4), 490-496. Nukada, H., McMorran, A. D., Baba, M., Ogasawara, S., & Yagihashi, S. (2010). Increased susceptibility to ischemia and macrophage activation in STZ-diabetic rat nerve. Brain Research, Advance Online Publication. doi: 10.1016/j. brainres.2010.11.084 Osborne, H. (2010). Stop injecting corticosteroid into patients with tennis elbow, they are much more likely to get better by themselves! Journal of Science and Medicine in Sport, 13(4), 380-381. doi: 10.1016/j.jsams.2009.09.009 Perez, D., Rudland, J. R., Wilson, H., Roberton, G., Gerrard, D., & Wheatley, A. (2009). The revised ‘Early Learning in Medicine’ curriculum at the University of Otago: Focusing on students, patients, and community. New Zealand Medical Journal, 122(1292). Retrieved from http://www.nzma.org.nz/journal/122-1292/3540/ Perry, W. R. G., & Wilkinson, T. J. (2010). Taking the pulse: Medical student workforce intentions and the impact of debt. New Zealand Medical Journal, 123(1318). Retrieved from http://www.nzma.org.nz/journal/archive.php Phipps-Green, A. J., Hollis-Moffatt, J. E., Dalbeth, N., Merriman, M. E., Topless, R., Gow, P. J., Harrison, A. A., Highton, J., Jones, P. B. B., Stamp, L. K., & Merriman, T. R. (2010). A strong role for the ABCG2 gene in susceptibility to gout in New Zealand Pacific Island and Caucasian, but not Mäori, case and control sample sets. Human Molecular Genetics, 19(24), 4813-4819. doi: 10.1093/hmg/ddq412 Reddel, H. K., Taylor, D. R., Bateman, E. D., Boulet, L-P., Boushey, H. A., Busse, W. W., Casale, T. B., et al. (2009). An official American Thoracic Society/European Respiratory Society statement: Asthma control and exacerbations: Standardising endpoints for clinical asthma trials and clinical practice. American Journal of Respiratory and Critical Care Medicine, 180(1), 59-99. doi: 10.1164/rccm.200801-060ST Salah Kamel, K., Lau, G., & Stringer, M. D. (2009). In vivo and in vitro morphometry of the human trachea. Clinical Anatomy, 22(5), 571-579. doi: 10.1002/ca.20815 Sandrini, A., Taylor, D. R., Thomas, P. S., & Yates, D. H. (2010). Fractional exhaled nitric oxide in asthma: An update. Respirology, 15(1), 57-70. doi: 10.1111/j.1440-1843.2009.01616.x Schneiders, A. G., Sullivan, S. J., Gray, A. R., Hammond-Tooke, G. D., & McCrory, P. R. (2010). Normative values for three clinical measures of motor performance used in the neurological assessment of sports concussion. Journal of Science and Medicine in Sport, 13(2), 196-201. doi: 10.1016/j.jsams.2009.05.004 Schultz, M., & Butt, G. (2010). E. coli Nissle 1917 in the treatment of inflammatory bowel disease. Practical Gastroenterology, 34(3), 11-19. Schultz, M., Davidson, A., Donald, S., Targonska, B., Turnbull, A., Weggery, S. E., Livingstone, V., & Dockerty, J. D. (2009). Gastroenterology service in a teaching hospital in rural New Zealand, 1991-2003. World Journal of Gastroenterology, 15(5), 583-590. doi: 10.3748/wjg.15.583 Schultz, M., Gearry, R., Walmsley, R., Day, A. S., Fraser, A., Wyeth, J., Barclay, M., Clover, G., & Whiteside, C. (2010). New Zealand Society of Gastroenterology statement on the use of biological therapy in inflammatory bowel disease. New Zealand Medical Journal, 123(1314). Retrieved from http://www.nzma.org.nz/journal/archive.php Sehgal, P., Sopoaga, F., & Beresford, R. (2009). Bridging the gap: Strategies to promote the recruitment and retention of Pacific Islanders into the health professions. New Zealand Medical Students Journal, 9, 5-8.

154 RESEARCH REPORT 2009/2010 Smith, A. D., Cowan, J. O., & Taylor, D. R. (2009). Exhaled nitric oxide levels in asthma: Personal best versus reference values. Journal of Allergy and Clinical Immunology, 124(4), 714-718. doi: 10.1016/j.jaci.2009.07.020 Stamp, L. K., Easson, A., Pettersson, L., Highton, J., & Hessian, P. A. (2009). Monocyte derived interleukin (IL)-23 is an important determinant of synovial IL-17A expression in rheumatoid arthritis. Journal of Rheumatology, 36(11), 2403- 2408. doi: 10.3899/jrheum.081304 Stebbings, S., Herbison, P., Doyle, T. C. A., Treharne, G. J., & Highton, J. (2010). A comparison of fatigue correlates in rheumatoid arthritis and osteoarthritis: Disparity in associations with disability, anxiety and sleep disturbance. Rheumatology, 49(2), 361-367. doi: 10.1093/rheumatology/kep367 Stebbings, S. M., Taylor, C., Tannock, G. W., Baird, A. A., & Highton, J. (2009). The immune response to autologous bacteroides in ankylosing spondylitis is characterized by reduced interleukin 10 production. Journal of Rheumatology, 36(4), 797-800. doi: 10.3899/jrheum.080964 Stebbings, S., & Treharne, G. J. (2010). Fatigue in rheumatic disease: An overview. International Journal of Clinical Rheumatology, 5(4), 487-502. doi: 10.2217/ijr.10.30 Sutherland, T. J. T., Sears, M. R., McLachlan, C. R., Poulton, R., & Hancox, R. J. (2009). Leptin, adiponectin, and asthma: Findings from a population-based cohort study. Annals of Allergy, Asthma and Immunology, 103(2), 101-107. Sutherland, W. H. F., de Jong, S. A., Hessian, P. A., & Williams, M. J. A. (2010). Ingestion of native and thermally oxidized polyunsaturated fats acutely increases circulating numbers of endothelial microparticles. Metabolism, 59(3), 446-453. doi: 10.1016/j.metabol.2009.07.033 Tannock, G. W., Tiong, I. S., Priest, P., Munro, K., Taylor, C., & Schultz, M. (2010). Testing probiotic strain Escherichia coli Nissle 1917 (Mutaflor®) for ability to reduce carriage of multi-drug resistant E. coli by elderly residents of long term care facilities. Journal of Medical Microbiology, Advance Online Publication. doi: 10.1099/jmm.0.025874-0 Tarawhiti, L., Waters, D., Goulding, A., Jones, L., & Hale, L. (2009). Sarcopenic-obesity with polypharmacy is associated with gait and balance disturbances in older adults. New Zealand Medical Student Journal, 9, 19-25. Taub, C. C., Stoler, J. M., Perez-Sanz, T., Chu, J., Isselbacher, E. M., Picard, M. H., & Weyman, A. E. (2009). Mitral valve prolapse in Marfan Syndrome: An old topic revisited. Echocardiography, 26(4), 357-364. doi: 10.1111/j.1540- 8175.2008.00825.x Taylor, D. R. (2009). Risk assessment in asthma and COPD: A potential role for biomarkers? Thorax, 64(3), 261-264. Taylor, D. R., Palmay, R., Cowan, J. O., & Herbison, G. P. (2010). Long term performance characteristics of an electrochemical nitric oxide analyser. Respiratory Medicine, Advance Online Publication. doi: 10.1016/j.rmed.2010.09.001 Taylor, R. W., Brooking, L., Williams, S. M., Manning, P. J., Sutherland, W. H., Coppell, K. J., Tipene-Leach, D., Dale, K. S., McAuley, K. A., & Mann, J. I. (2010). Body mass index and waist circumference cutoffs to define obesity in indigenous New Zealanders. American Journal of Clinical Nutrition, 92, 390-397. doi: 10.3945/ajcn.2010.29317 Taylor, R. W., Grant, A. M., Williams, S. M., & Goulding, A. (2010). Sex differences in regional body fat distribution from pre- to postpuberty. Obesity, 18(7), 1410-1416. doi: 10.1038/oby.2009.399 Taylor, R. W., Williams, S. M., Grant, A. M., Taylor, B. J., & Goulding, A. (2010). Predictive ability of waist-to-height in relation to adiposity in children is not improved with age and sex-specific values. Obesity, Advance Online Publication. doi: 10.1038/oby.2010.217 Thamrin, C., Stern, G., Strippoli, M-P. F., Kuehni, C. E., Suki, B., Taylor, D. R., & Frey, U. (2009). Fluctuation analysis of

lung function as a predictor of long-term response to b2agonists. European Respiratory Journal, 33(3), 486-493. doi: 10.1183/09031936.00106208 Thamrin, C., Taylor, D. R., Jones, S. L., Suki, B., & Frey, U. (2010). Variability of lung function predicts loss of asthma control following withdrawal of inhaled corticosteroid treatment. Thorax, 65(5), 403-408. doi: 10.1136/thx.2009.129668 Thomas, K. N., Cotter, J. D., Galvin, S. D., Williams, M. J. A., Willie, C. K., & Ainslie, P. N. (2009). Initial orthostatic hypotension is unrelated to orthostatic tolerance in healthy young subjects. Journal of Applied Physiology, 107(2), 506-517. doi: 10.1152/japplphysiol.91650.2008 Thomas, K. N., Galvin, S. D., Williams, M. J. A., Willie, C. K., & Ainslie, P. N. (2010). Identical pattern of cerebral hypoperfusion during different types of syncope. Journal of Human Hypertension, 24(7), 458-466. doi: 10.1038/ jhh.2009.93 Ting, Y. T., Coates, T. P., Marti, H. P., Dunn, A. C., Parker, R. M., Pickering, J. W., Jack, R. W., Kemp, R. A., Walker, R. J., & McLellan, A. D. (2010). Urinary soluble HLA-DR is a potential biomarker for acute renal transplant rejection. Transplantation, 89(9), 1071-1078. doi: 10.1097/TP.0b013e3181d15492 Todd, A. S., MacGinley, R. J., Schollum, J. B. W., Johnson, R. J., Williams, S. M., Sutherland, W. H. F., Mann, J. I., & Walker, R. J. (2010). Dietary salt loading impairs arterial vascular reactivity. American Journal of Clinical Nutrition, 91(3), 557-564. doi: 10.3945/ajcn.2009.28645 Tordoff, J. M., Bagge, M. L., Gray, A. R., Campbell, A. J., & Norris, P. T. (2010). Medicine-taking practices in community- dwelling people aged ³75 years in New Zealand. Age and Ageing, 39(5), 574-580. doi: 10.1093/ageing/afq069 van Dalen, C. J., Aldridge, R. E., Chan, T., Senthilmohan, R., Hancox, R. J., Cowan, J. O., Taylor, D. R., Town, G. I., & Kettle, A. J. (2009). Bromotyrosines in sputum proteins and treatment effects of terbutaline and budesonide in asthma. Annals of Allergy Asthma & Immunology, 103(4), 348-353. Wan Taib, W. R., Smyth, D. J., Merriman, M. E., Dalbeth, N., Gow, P. J., Harrison, A. A., Highton, J., Jones, P. B. B., Stamp, L., Steer, S., Todd, J. A., & Merriman, T. R. (2010). The PTPN22 locus and rheumatoid arthritis: No evidence for an effect on risk independent of Arg620Trp. PLoS ONE, 5(10), e13544. doi: 10.1371/journal.pone.0013544

Division of HEALTH SCIENCES 155 Waters, D. L., Hale, L., Grant, A. M., Herbison, P., & Goulding, A. (2010). Osteoporosis and gait and balance disturbances in older sarcopenic obese New Zealanders. Osteoporosis International, 21(2), 351-357. doi: 10.1007/s00198-009-0947-5 Williams, S. M., & Goulding, A. (2009). Patterns of gowth associated with the timing of adiposity rebound. Obesity, 17(2), 335-341. doi: 10.1038/oby.2008.547 Wong, C-K., Gao, W., Stewart, R. A., Benatar, J., French, J. K., et al. (2010). aVR ST elevation: An important but neglected sign in ST elevation acute myocardial infarction. European Heart Journal, 31, 1845-1853. doi: 10.1093/eurheartj/ehq161

Wong, C-K., Gao, W., Stewart, R. A., French, J. K., Aylward, P. E., et al. (2010). Prognostic value of lead V1 ST elevation during acute inferior myocardial infarction. Circulation, 122(5), 463-469. doi: 10.1161/circulationaha.109.924068 Wong, C-K., Gao, W., Stewart, R. A. H., French, J. K., Aylward, P. E. G., & White, H. D. (2009). Relationship of QRS duration at baseline and changes over 60 min after fibrinolysis to 30-day mortality with different locations of ST elevation myocardial infarction: Results from the Hirulog and Early Reperfusion or Occlusion-2 trial. Heart, 95(4), 276-282. doi: 10.1136/ hrt.2008.146365 Wong, C-K., Leon de la Barra, S., & Herbison, P. (2010). Does ST resolution achieved via different reperfusion strategies (fibrinolysis vs percutaneous coronary intervention) have different prognostic meaning in ST-elevation myocardial infarction? A systematic review. American Heart Journal, 160(5), 842-848.e2. doi: 10.1016/j.ahj.2010.06.050 Wong, C-K., Tang, E. W., & Herbison, P. (2009). Prognostic interactions between statins and in-hospital revascularisation on the outcome of acute coronary syndrome. Heart, Lung & Circulation, 18(4), 262-265. doi: 10.1016/j.hlc.2008.12.001 Wong, C-K., Tang, E. W., & Herbison, P. (2009). The use of different evidence-based medications and 5-year survival after an acute coronary syndrome: An observational study. International Journal of Cardiology, 132(2), 197-202. doi: 10.1016/j. ijcard.2007.11.005 Yagihashi, S., Mizukami, H., Ogasawara, S., Yamagishi, S-I., Nukada, H., et al. (2010). The role of the polyol pathway in acute kidney injury caused by hindlimb ischaemia in mice. Journal of Pathology, 220(5), 530-541. doi: 10.1002/path.2671 Yoga, R., Theis, J-C., Walton, M., & Sutherland, W. (2009). Interleukin-6 as an early marker for fat embolism. Journal of Orthopaedic Surgery and Research, 4. doi: 10.1186/1749-799X-4-18 Zou, D., Yoon, H-S., Anjomshoaa, A., Perez, D., Fukuzawa, R., Guilford, P., & Humar, B. (2009). Increased levels of active c-Src distinguish invasive from in situ lobular lesions. Breast Cancer Research, 11(4), R45. doi: 10.1186/bcr2332 Zou, D., Yoon, H-S., Perez, D., Weeks, R. J., Guilford, P., & Humar, B. (2009). Epigenetic silencing in non-neoplastic epithelia identifies E-cadherin (CDH1) as a target for chemoprevention of lobular neoplasia. Journal of Pathology, 218(2), 265-272. doi: 10.1002/path.2541

Journal - Research Other Al-Sallami, H., Jordan, S., Ferguson, R., Medlicott, N. J., Schollum, J., & Duffull, S. B. (2010). Current enoxaparin dosing guidelines have dubious credibility [Viewpoint]. New Zealand Medical Journal, 123(1313). Retrieved from http://www. nzma.org.nz/journal/archive.shtml Campbell, A. J., & Robertson, M. C. (2009). Not a retreat, but advancing on numerous fronts [Letter to the editor]. Journal of the American Geriatrics Society, 57(3), 565-566. doi: 10.1111/j.1532-5415.2009.02154.x Campbell, A. J., Sanderson, G., & Robertson, M. C. (2010). Poor vision and falls [Editorial]. BMJ, 340(7760), 1313-1314. doi: 10.1136/bmj.c2456 Cummings, J. H., Mann, J. I., Nishida, C., & Vorster, H. H. (2009). Dietary fibre: An agreed definition [Comment]. Lancet, 373(9661), 365-366. Derraik, J. G. B., Slaney, D., Nye, E. R., & Weinstein, P. (2009). Vector-borne disease prevention: The need for a joint South Pacific approach. New Zealand Medical Journal, 122(1299). Retrieved from http://www.nzma.org.nz/ journal/122-1299/3707/ Galvin, S., Chen, V., Bunton, R., & Doyle, T. (2010). Sutureless pericardial patch augmentation for impending left ventricular free wall rupture [Case report]. Interactive Cardiovascular and Thoracic Surgery, 10, 341-343. doi: 10.1510/ icvts.2009.217125 Galvin, S. D., Sampangi, N. R., Wilson, B. K. J., & Samalia, K. P. (2010). Periurethral abscess: An unusual source of sepsis. ANZ Journal of Surgery, 80(9), 653-654. Galvin, S. D., Wademan, B., Chu, J., & Bunton, R. W. (2010). Benign metastasizing leiomyoma: A rare metastatic lesion in the right ventricle [Case report]. Annals of Thoracic Surgery, 89(1), 279-281. doi: 10.1016/j.athoracsur.2009.06.050 Jones, G. T., Deng, M., Hammond-Tooke, G. D., McCormick, S. P. A., & van Rij, A. M. (2009). Increased plasma lipoprotein(a) found in large-artery atherosclerotic, but not small-artery occlusive, stroke [Letter to the editor]. Clinical Chemistry, 55(10), 1888-1890. doi: 10.1373/clinchem.2009.126771 Kong, V., Beckert, L., & Awunor-Renner, C. (2009). A case of beta lactam-induced visual hallucination. New Zealand Medical Journal, 122(1298). Retrieved from http://www.nzma.org.nz/journal/122-1298/3689/content.pdf Mann, J. (2009). Intakes of fruit juices and sugar-sweetened beverages and risk of type 2 diabetes [Commentary]. International Diabetes Monitor, 21(5), 193-195. Mann, J., & Nye, E. R. (2009). Fad diets in Sweden, of all places [Comment]. Lancet, 374(9692), 767-769. Phipps-Green, A. J., Topless, R. K. G., Merriman, M. E., Dalbeth, N., Gow, P. J., Harrison, A. A., Highton, J., Jones, P. B. B., Stamp, L. K., Harrison, P., Wordsworth, B. P., & Merriman, T. R. (2009). No evidence for association of the systemic lupus erythematosus-associated ITGAM variant, R77H, with rheumatoid arthritis in the Caucasian population [Letter to the editor]. Rheumatology, 48(12), 1614-1615. doi: 10.1093/rheumatology/kep254

156 RESEARCH REPORT 2009/2010 Schultz, M., Roberts, R. L., & Butt, A. G. (2010). Understanding probiotic treatment strategies in inflammatory bowel disease, with a special emphasis on the intestinal barrier. European Gastroenterology & Hepatology Review, 6(1), 58-65. Tan, E., Young, D., McLaren, B., & Wright, A. (2010). Early-stage testicular cancer: A rare association with dermatomyositis [Case report]. Australasian Journal of Dermatology, 51(2), 139-141. doi: 10.1111/j.1440-0960.2009.00617.x Taylor, D. R. (2009). The b-agonist saga and its clinical relevance: On and on it goes [Clinical Commentary]. American Journal of Respiratory and Critical Care Medicine, 179(11), 976-978. doi: 10.1164/rccm.200901-0055CC Taylor, D. R. (2010). An eye to the future: Exhaled nitric oxide as a predictor of clinical outcomes in asthma [Editorial]. European Respiratory Journal, 35(6), 1200-1202. doi: 10.1183/09031936.00003310 Taylor, D. R., & Cowan, D. C. (2010). Assessing airway inflammation. Thorax, Advance Online Publication. doi: 10.1136/ thx.2009.132985 Tipene-Leach, D. (2010). Sudden infant death and co-sleeping: A better message [Letter]. New Zealand Medical Journal, 123(1309). Retrieved from http://www.nzma.org.nz/journal/123-1309/3998/content.pdf Walker, R. (2010). The composition of peritoneal dialysis solutions: Tinkering or significant changes? [Commentary]. Peritoneal Dialysis International, 30(6), 600-601. doi: 10.3747/pdi.2010.00076 Williams, S. M., & Goulding, A. (2009). Early adiposity rebound is an important predictor of later obesity [Letter to the editor]. Obesity, 17(7), 1310. doi: 10.1038/oby.2009.104 Wong, C-K. (2010). Usefulness of leads V7, V8, and V9 ST elevation to diagnose isolated posterior myocardial infarction [Letter to the editor]. International Journal of Cardiology, Advance Online Publication. doi: 10.1016/j.ijcard.2010.10.137

Journal - Professional & Other Non-Research Articles Booker, C. (2010). The accelerator hypothesis: Insulin resistance as the central cause of type 1 and type 2 diabetes [Letter to the editor]. International Journal of Obesity, 34(1), 210-211. doi: 10.1038/ijo.2009.190 Campbell, A. J. (2009). Assertive screening: Health checks prior to exercise programmes in older people [Editorial]. British Journal of Sports Medicine, 43(1), 5. doi: 10.1136/bjsm.2008.053587 Chalcroft, S. C. W. (2010). Assigning ¢frailty¢ [Letter to the editor]. Age and Ageing, 39(3), 405. Dummer, J. F., & Taylor, D. R. (2010). Defining the role of exhaled nitric oxide measurements in COPD [Editorial]. Respirology, 15, 385-386. doi: 10.1111/j.1440-1843.2010.01730.x Taylor, D. R. (2009). Exhaled nitric oxide: Still alive, not laid to rest. American Journal of Respiratory and Critical Care Medicine, 179(2), 88-89. doi: 10.1164/rccm.200810-1605ED Taylor, D. R., & Bush, A. (2009). Clinical use of exhaled nitric oxide measurements [Correspondence]. Lancet, 373(9661), 382. doi: 10.1016/S0140-6736(09)60134-3 Taylor, D. R., & Dummer, J. (2010). Exhaled nitric oxide and COPD [Letter]. European Respiratory Journal, 36(3), 692. doi: 10.1183/09031936.00058310 Taylor, D. R., & Reddel, H. K. (2009). [Authors response to the letter To the editors]. European Respiratory Journal, 33(3), 706. doi: 10.1183/09031936.00173008

Dunedin School of Medicine Ophthalmology Section

Chapter in Book - Research Thompson, A. M., Bevin, T. H., & Molteno, A. C. B. (2009). Surgical technique 1 (Molteno Glaucoma Implant). In T. M. Shaarawy, M. B. Sherwood, R. A. Hitchings, & J. G. Crowston (Eds.), Glaucoma: Surgical management (Vol. 2) (pp. 403- 416). Edinburgh, UK: Saunders.

Journal - Research Article Brian, G., du Toit, R., Ramke, J., & Palagyi, A. (2010). Monitoring and evaluation of refractive error and presbyopia for Vision 2020. Clinical & Experimental Ophthalmology, 38(3), 249-254. doi: 10.1111/j.1442-9071.2010.02210.x Brian, G., du Toit, R., Ramke, J., & Szetu, J. (2010). Population-based study of self-reported ocular trauma in Fiji. Clinical & Experimental Ophthalmology, Advance Online Publication. doi: 10.1111/j.1442-9071.2010.02476.x Brian, G., Fischer-Harder, K., Sikivou, B., Qalo Qoqonokana, M., Szetu, J., & Ramke, J. (2010). Diabetic eye disease among adults in Fiji with self-reported diabetes. Clinical and Experimental Ophthalmology, Advance Online Publication. doi: 10.1111/j.1442-9071.2010.02361.x Brian, G., Ramke, J., Maher, L., Page, A., & Szetu, J. (2010). The prevalence of diabetes among adults aged 40 years and over in Fiji. New Zealand Medical Journal, 123(1327). Retrieved from http://www.nzma.org.nz/journal/123-1327/4468/content.pdf Brian, G., Ramke, J., Szetu, J., & Qalo Qoqonokana, M. (2010). Cataract and its surgery in Fiji. Clinical & Experimental Ophthalmology, Advance Online Publication. doi: 10.1111/j.1442-9071.2010.02477.x Derrett, S., Bevin, T. H., Herbison, P., & Paul, C. (2009). Access to elective surgery in New Zealand: Considering equity and the private and public mix. International Journal of Health Planning and Management, 24(2), 147-160. doi: 10.1002/hpm.978 Gale, J., Wells, A. P., & Wilson, G. (2009). Effects of exercise on ocular physiology and disease. Survey of Ophthalmology, 54(3), 349-355. doi: 10.1016/j.survophthal.2009.02.005

Division of HEALTH SCIENCES 157 Johnston, N. R., & Sanderson, G. (2010). Orbital infection in New Zealand: Increased incidence due to socioeconomic deprivation and ethnicity. New Zealand Medical Journal, 123(1320). Retrieved from http://www.nzma.org.nz/journal/ archive.php Kuo, H-K., Kuo, M-T., Tiong, I-S., Wu, P-C., Chen, Y-J., & Chen, C-H. (2010). Visual acuity as measured with Landolt C chart and Early Treatment of Diabetic Retinopathy Study (ETDRS) chart. Graefe’s Archive for Clinical and Experimental Ophthalmology, Advance Online Publication. doi: 10.1007/s00417-010-1461-3 McCluskey, P., Molteno, A., Wakefield, D., & Di Girolamo, N. (2009). Otago Glaucoma Surgery Outcome Study: The pattern of expression of MMPs and TIMPs in bleb capsules surrounding Molteno implants. Investigative Ophthalmology & Visual Science, 50(5), 2161-2164. doi: 10.1167/iovs.08-2063 Memon, S., & Wilson, G. A. (2009). Bilateral inferior visual field defects from a childhood near-drowning. New Zealand Medical Journal, 122(1290). Retrieved from http://www.nzma.org.nz/journal/122-1290/ Molteno, A. C. B., Thompson, A. M., Bevin, T. H., & Dempster, A. G. (2009). Otago Glaucoma Surgery Outcome Study: Tissue matrix breakdown by apoptotic cells in capsules surrounding Molteno implants. Investigative Ophthalmology & Visual Science, 50(3), 1187-1197. doi: 10.1167/iovs.07-1424 Oliver, G. F., Wilson, G. A., & Everts, R. J. (2009). Acute infective conjunctivitis: Evidence review and management advice for New Zealand practitioners. New Zealand Medical Journal, 122(1298). Retrieved from http://www.nzma.org.nz/ journal/122-1298/ Palagyi, A., Brian, G., & Ramke, J. (2010). Training and using mid-level eye care workers: Early lessons from Timor-Leste. Clinical and Experimental Ophthalmology, 38(8), 805-811. doi: 10.1111/j.1442-9071.2010.02338.x Pick, Z. S., & Wilson, G. A. (2009). Tapioca melanoma of the iris. Clinical and Experimental Optometry, 92(2), 154-156. doi: 10.1111/j.1444-0938.2008.00344.x Pradhan, M. A., Ng, Y., Strickland, A., George, P. M., Raizis, A., Warrington, J., & Vincent, A. L. (2010). Role of genetic testing in retinoblastoma management at a tertiary referral centre. Clinical and Experimental Ophthalmology, 38, 231-236. doi: 10.1111/j.1442-9071.2010.02239.x Pradhan, M., Hayes, I., & Vincent, A. (2009). An audit of genetic testing in diagnosis of inherited retinal disorders: A prerequisite for gene-specific intervention. Clinical and Experimental Ophthalmology, 37, 703-711. doi: 10.1111/j.1442- 9071.2009.02129.x Qalo Qoqonokana, M., Brian, G., Ramke, J., Garcia, J., & Szetu, J. (2010). Diabetic retinopathy in a hospital eye clinic population in Honiara, Solomon Islands. Clinical and Experimental Ophthalmology, Advance Online Publication. doi: 10.1111/j.1442-9071.2010.02356.x Rahman, A. M. A., Madge, S. N., Billing, K., Anderson, P. J., Leibovitch, I., Selva, D., & David, D. (2009). Craniofacial fibrous dysplasia: Clinical characteristics and long-term outcomes. Eye, 23(12), 2175-2181. doi: 10.1038/eye.2009.6 Tannock, G. W., Tiong, I. S., Priest, P., Munro, K., Taylor, C., & Schultz, M. (2010). Testing probiotic strain Escherichia coli Nissle 1917 (MutaflorÒ) for ability to reduce carriage of multi-drug resistant E. coli by elderly residents of long term care facilities. Journal of Medical Microbiology, Advance Online Publication. doi: 10.1099/jmm.0.025874-0 Vincent, A. L., Markie, D. M., De Karolyi, B., Wheeldon, C. E., & Patel, D. V. (2009). Exclusion of known corneal dystrophy genes in an autosomal dominant pedigree of a unique anterior membrane corneal dystrophy. Molecular Vision, 15(182), 1700-1708. Vincent, A. L., Niederer, R. L., Richards, A., Karolyi, B., Patel, D. V., & McGhee, C. N. J. (2009). Phenotypic characterisation and ZEB1 mutational analysis in posterior polymorphous corneal dystrophy in a New Zealand population. Molecular Vision, 15, 2544-2553. Retrieved from http://www.molvis.org/molvis/v15/a273

Journal - Research Other Campbell, A. J., Sanderson, G., & Robertson, M. C. (2010). Poor vision and falls [Editorial]. BMJ, 340(7760), 1313-1314. doi: 10.1136/bmj.c2456 Downie, A. C., Mackey, D. A., & Vote, B. J. (2009). Isolated corneal opacification and microphthalmia: A suspected warfarin embryopathy [Letter to the editor]. Clinical and Experimental Ophthalmology, 37, 624-625. doi: 10.1111/j.1442- 9071.2009.02072.x Pradhan, M., Hart, R., & Vincent, A. (2009). Concordance of congenital ptosis in monozygotic twins. Clinical and Experimental Ophthalmology, 37(7), 747-748. doi: 10.1111/j.1442-9071.2009.02123.x Sheck, L. H. N., Field, A. P., McRobbie, H., & Wilson, G. A. (2009). Helping patients to quit smoking in the busy optometric practice [Guest Editorial]. Clinical and Experimental Optometry, 92(2), 75-77. doi: 10.1111/j.1444-0938.2009.00348.x

Journal - Professional & Other Non-Research Articles Molteno, A. C. B., & Bevin, T. H. (2009). [Response to the letter Are failure rates of primary trabeculectomy really increasing?]. Clinical and Experimental Ophthalmology, 37(4), 423-424.

158 RESEARCH REPORT 2009/2010 Dunedin School of Medicine Orthopaedic Surgery Section

Journal - Research Article Abbott, J. H., Robertson, M. C., McKenzie, J. E., Baxter, G. D., Theis, J-C., Campbell, A. J., & the MOA Trial Team (2009). Exercise therapy, manual therapy, or both, for osteoarthritis of the hip or knee: A factorial randomised controlled trial protocol. Trials, 10(11). doi: 10.1186/1745-6215-10-11 Aghayev, E., Beck, A., Staub, L. P., Dietrich, D., Melloh, M., Orljanski, W., & Röder, C. (2010). Simultaneous bilateral hip replacement reveals superior outcome and fewer complications than two-stage procedures: A prospective study including 1819 patients and 5801 follow-ups from a total joint replacement registry. BMC Musculoskeletal Disorders, 11, 245. Retrieved from http://www.biomedcentral.com/1471-2474/11/245 Avenell, A., Gillespie, W. J., Gillespie, L. D., & O’Connell, D. (2009). Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis. Cochrane Database of Systematic Reviews, 2, CD000227. doi: 10.1002/14651858.CD000227.pub3 Barz, T., Melloh, M., Staub, L., Lord, S. J., Lange, J., Röder, C., Theis, J-C., & Merk, H. R. (2010). Nerve root sedimentation sign: Evaluation of a new radiological sign in lumbar spinal stenosis. Spine, 35(8), 892-897. doi: 10.1097/BRS.0b013e3181c7cf4b Cameron, I. D., Murray, G. R., Gillespie, L. D., Robertson, M. C., Hill, K. D., Cumming, R. G., & Kerse, N. (2010). Interventions for preventing falls in older people in nursing care facilities and hospitals. Cochrane Database of Systematic Reviews, (1), CD005465. doi: 10.1002/14651858.CD005465.pub2 Gabel, C. P., Melloh, M., Yelland, M., Burkett, B., & Roiko, A. (2010). Predictive ability of a modified Örebro Musculoskeletal Pain Questionnaire in an acute/subacute low back pain working population. European Spine Journal, Advance Online Publication. doi: 10.1007/s00586-010-1509-4 Gabel, C. P., Michener, L. A., Melloh, M., & Burkett, B. (2010). Modification of the upper limb functional index to a three- point response improves clinimetric properties. Journal of Hand Therapy, 23(1), 41-52. doi: 10.1016/j.jht.2009.09.007 Gabel, C. P., Yelland, M., Melloh, M., & Burkett, B. (2009). A modified QuickDASH-9 provides a valid outcome instrument for upper limb function. BMC Musculoskeletal Disorders, 10, 161. doi: 10.1186/1471-2474-10-161 Gillespie, L. D., Robertson, M. C., Gillespie, W. J., Lamb, S. E., Gates, S., Cumming, R. G., & Rowe, B. H. (2009). Interventions for preventing falls in older people living in the community. Cochrane Database of Systematic Reviews, (2), CD007146. doi: 10.1002/14651858.CD007146.pub2 Gwynne-Jones, D. P., Garneti, N., Wainwright, C., Matheson, J. A., & King, R. (2009). The Morscher Press Fit acetabular component: A nine- to 13- year review. Journal of Bone & Joint Surgery (Br), 91-B(7), 859-864. doi: 10.1302/0301-620X.91B7.22013 Hendrick, P., Milosavljevic, S., Bell, M. L., Hale, L., Hurley, D. A., McDonough, S. M., Melloh, M., & Baxter, G. D. (2009). Does physical activity change predict functional recovery in low back pain? Protocol for a prospective cohort study. BMC Musculoskeletal Disorders, 10, 136. doi: 10.1186/1471-2474-10-136 Kessler, J. T., Melloh, M., Zweig, T., Aghayev, E., & Röder, C. (2010). Development of a documentation instrument for the conservative treatment of spinal disorders in the International Spine Registry, Spine Tango. European Spine Journal, Advance Online Publication. doi: 10.1007/s00586-010-1474-y Knight, M. M., McGlashan, S. R., Garcia, M., Jensen, C. G., & Poole, C. A. (2009). Articular chondrocytes express connexin 43 hemichannels and P2 receptors: A putative mechanoreceptor complex involving the primary cilium? Journal of Anatomy, 214(2), 275-283. doi: 10.1111/j.1469-7580.2008.01021.x McGlashan, S. R., Knight, M. M., Chowdhury, T. T., Joshi, P., Jensen, C. G., Kennedy, S., & Poole, C. A. (2010). Mechanical loading modulates chondrocyte primary cilia incidence and length. Cell Biology International, 34(5), 441-446. doi: 10.1042/cbi20090094 Melloh, M., Elfering, A., Egli Presland, C., Roeder, C., Barz, T., Rolli Salathé, C., Tamcan, O., Mueller, U., & Theis, J. C. (2009). Identification of prognostic factors for chronicity in patients with low back pain: A review of screening instruments. International Orthopaedics, 33(2), 301-313. doi: 10.1007/s00264-008-0707-8 Patton, A., Bourne, J., & Theis, J-C. (2010). Patterns of lower limb fractures sustained during snowsports in Otago, New Zealand. New Zealand Medical Journal, 123(1316). Retrieved from http://www.nzma.org.nz/journal/123-1316/4160/ content.pdf Röder, C., Staub, L., Dietrich, D., Zweig, T., Melloh, M., & Aebi, M. (2009). Benchmarking with Spine Tango: Potentials and pitfalls. European Spine Journal, 18(Suppl. 3), S305-S311. doi: 10.1007/s00586-009-0943-7 Taylor, F., Sims, M., Theis, J-C., & Herbison, G. P. (2009). Interventions for treating acute elbow dislocations in adults. Cochrane Database of Systematic Reviews, (3), CD007908. doi: 10.1002/14651858.CD007908 Yoga, R., Theis, J-C., Walton, M., & Sutherland, W. (2009). Interleukin-6 as an early marker for fat embolism. Journal of Orthopaedic Surgery and Research, 4. doi: 10.1186/1749-799X-4-18 Zweig, T., Mannion, A. F., Grob, D., Melloh, M., Munting, E., Tuschel, A., Aebi, M., & Röder, C. (2009). How to Tango: A manual for implementing Spine Tango. European Spine Journal, 18(Suppl. 3), S312-S320. doi: 10.1007/s00586-009-1074-x

Division of HEALTH SCIENCES 159 Journal - Research Other Barz, T., Staub, L. P., Melloh, M., & Lord, S. J. (2010). In response [Letter]. Spine, 35(24), E1360. doi: 10.1097/ BRS.0b013e318200486e Gabel, C. P., Melloh, M., Michener, L. A., & Burkett, B. (2010). Clinimetric evaluation of measurement tools used in hand therapy to assess activity and participation [Letter to the editor]. Journal of Hand Therapy, 23(1), 83-84. doi: 10.1016/j. jht.2009.09.003 Locker, J., & Carstens, A. (2010). High-pressure injection of silica-based paint into a finger [Clinical correspondence]. New Zealand Medical Journal, 123(1316). Retrieved from http://www.nzma.org.nz/journal/123-1316/4161/content.pdf

Journal - Professional & Other Non-Research Articles Gabel, C. P., Melloh, M., & Burkett, B. (2009). Factor analysis findings for the NDI [Letter to the editor-in-chief]. Journal of Orthopaedic and Sports Physical Therapy, 39(11), 828-829. Gabel, C. P., Melloh, M., Michener, L. A., & Burkett, B. (2010). Did one measure fare better? [Letter to the editor]. Journal of Hand Therapy, 23(1), 83-84. doi: 10.1016/j.jht.2009.09.003

Working Paper; Discussion Paper; Technical Report Röder, C., Neukamp, M., Perler, G., Melloh, M., Zweig, T., Munting, E., & Aebi, M. (2010). SPINE TANGO Report: International 2009. Berne, Switzerland: MEMcenter Press. (pp. 1-47). Retrieved from http://www.eurospine.org/cm_data/ Spine_Tango_Report_2009-16.pdf Zweig, T., Aghayev, E., Melloh, M., Röder, C., & Aebi, M. (2009). SPINE TANGO Report: International 2006-2008. Berne, Switzerland: MEMcenter Press. (pp. 1-40). Retrieved from http://www.eurospine.org/cm_data/Spine_Tango_Report_Intl_ Print2.pdf

Dunedin School of Medicine Surgery Section

Authored Book - Other Australian and New Zealand working Party on the Management and Prevention of Venous Thromboembolism, & including van Rij, A. (2010). Prevention of venous thromboembolism: Best practice guidelines for Australia and New Zealand (5th ed.). Baulkham Hills, Australia: Health Education & Management Innovations.

Journal - Research Article Beshay, N., van Rij, A. M., & Woodfield, J. C. (2009). A meta-analysis of randomized, controlled trials assessing the prophylactic use of ceftriaxone: A study of wound, chest, and urinary infections. World Journal of Surgery, 33(12), 2538- 2550. doi: 10.1007/s00268-009-0158-4 Chan, E. C., Jones, G. T., Dusting, G. J., Datla, S. R., & Jiang, F. (2009). Prevention of aortic elastic lamina defects by losartan in apolipoprotein E-deficient mouse. Clinical and Experimental Pharmacology and Physiology, 36(9), 919-924. doi: 10.1111/j.1440-1681.2009.05169.x Dawes, P. J. D., & Al-Qudah, M. (2009). Tympanomastoidectomy: Planned second-look tympanotomy. Journal of Otolaryngology - Head and Neck Surgery, 38(3), 311-317. Dawes, P. J. D., & Welch, D. (2010). Childhood hearing and its relationship with tinnitus at thirty-two years of age. Annals of Otology, Rhinology and Laryngology, 119(10), 672-676. Fan, J-L., Burgess, K. R., Basnyat, R., Thomas, K. N., Peebles, K. C., Lucas, S. J., Lucas, R. A., Donnelly, J., Cotter, J. D., & Ainslie,

P. N. (2010). Influence of high altitude on cerebrovascular responsiveness to CO2. Journal of Physiology, 588(3), 539-549. doi: 10.1113/jphysiol.2009.184051 Galvin, S. D., Celi, L. A., Thomas, K. N., Clendon, T. R., Galvin, I. F., Bunton, R. W., & Ainslie, P. N. (2010). Effects of age and coronary artery disease on cerebrovascular reactivity to carbon dioxide in humans. Anaesthesia and Intensive Care, 38(4), 710-717. Galvin, S. D., Letts, J. A., & Sampangi, N. R. (2009). Magnetic resonance imaging of partial segmental priapism (segmental thrombosis of corpus cavernosum). Urology, 73(2), 275-276. doi: 10.1016/j.urology.2008.06.040 Golledge, J., Clancy, P., Jones, G. T., Cooper, M., Palmer, L. J., van Rij, A. M., & Norman, P. E. (2009). Possible association between genetic polymorphisms in transforming growth factor b receptors, serum transforming growth factor b1 concentration and abdominal aortic aneurysm. British Journal of Surgery, 96(6), 628-632. doi: 10.1002/bjs.6633 Gretarsdottir, S., Baas, A. F., Thorleifsson, G., Holm, H., den Heijer, M., de Vries, J-P. P. M., Kranendonk, S. E., Zeebregts, C. J. A. M., van Sterkenburg, S. M., Geelkerken, R. H., van Rij, A. M., Williams, M. J. A., ..., Jones, G. T., et al. (2010). Genome- wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm. Nature Genetics, Advance Online Publication. doi: 10.1038/ng.622 Gudbjartsson, D. F., Bjornsdottir, U. S., Halapi, E., ..., Williams, M. J. A., van Rij, A. M., Jones, G. T., et al. (2009). Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nature Genetics, 41(3), 342-347. doi: 10.1038/ng.323

160 RESEARCH REPORT 2009/2010 Hollis-Moffatt, J. E., Chen-Xu, M., Topless, R., Dalbeth, N., Gow, P. J., Harrison, A. A., Highton, J., Jones, P. B. B., Nissen, M., Smith, M. D., van Rij, A., Jones, G. T., Stamp, L. K., & Merriman, T. R. (2010). Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: Confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance. Arthritis Research & Therapy, 12(3), R116. doi: 10.1186/ar3053 Jaye, C., Egan, T., Smith-Han, K., & Thompson-Fawcett, M. (2009). Teaching and learning in the hospital ward. New Zealand Medical Journal, 122(1304). Retrieved from http://www.nzma.org.nz/journal/archive.shtml Jones, G. T., Grant, M. W., Thomson, I. A., Hill, B. G., & van Rij, A. M. (2009). Characterization of a porcine model of chronic superficial varicose veins. Journal of Vascular Surgery, 49(6), 1554-1561. doi: 10.1016/j.jvs.2009.01.070 Jones, G. T., Tarr, G. P., Phillips, L. V., Wilkins, G. T., van Rij, A. M., & Williams, M. J. A. (2009). Active matrix metalloproteinases 3 and 9 are independently associated with coronary artery in-stent restenosis. Atherosclerosis, 207(2), 603-607. doi: 10.1016/j.atherosclerosis.2009.05.036 Jones, V. S., McCall, J. L., Thomas, G., Stormon, M., & Shun, A. (2010). Reverse portal flow after liver transplantation: Ominous or acceptable? Pediatric Transplantation, 14(4), E34-E37. doi: 10.1111/j.1399-3046.2008.01121.x Lucas, S. J. E., Tzeng, Y. C., Galvin, S. D., Thomas, K. N., Ogoh, S., & Ainslie, P. N. (2010). Influence of changes in blood pressure on cerebral perfusion and oxygenation. Hypertension, 55, 698-705. doi: 10.1161/ HYPERTENSIONAHA.109.146290 Mathur, S., Plank, L. D., McCall, J. L., Shapkov, P., McIlroy, K., Gillanders, L. K., et al. (2010). Randomized controlled trial of preoperative oral carbohydrate treatment in major abdominal surgery. British Journal of Surgery, 97, 485-494. doi: 10.1002/bjs.7026 Michelsen, H. B., Thompson-Fawcett, M., Lundby, L., Krogh, K., Laurberg, S., & Buntzen, S. (2010). Six years of experience with sacral nerve stimulation for fecal incontinence. Diseases of the Colon & Rectum, 53(4), 414-421. doi: 10.1007/ DCR.0b013e3181ca7dc2 Murrell, C. J., Cotter, J. D., George, K. P., Shave, R., Wilson, L. C., Thomas, K. N., Williams, M. J. A., Lowe, T., & Ainslie, P. N. (2009). Influence of age on syncope following prolonged exercise: Differential responses but similar orthostatic intolerance. Journal of Physiology, 587(24), 5959-5969. doi: 10.1113/jphysiol.2009.179549 Murrell, C. J., Cotter, J. D., George, K., Shave, R., Wilson, L., Thomas, K., Williams, M. J. A., & Ainslie, P. N. (2010). Syncope is unrelated to supine and postural hypotension following prolonged exercise. European Journal of Applied Physiology and Occupational Physiology, Advance Online Publication. doi: 10.1007/s00421-010-1671-8 Nasri, S., Anjomshoaa, A., Song, S., Guilford, P., McNoe, L., Black, M., Phillips, V., Reeve, A., & Humar, B. (2010). Oligonucleotide array outperforms SNP array on formalin-fixed paraffin-embedded clinical samples. Cancer Genetics and Cytogenetics, 198(1), 1-6. doi: 10.1016/j.cancergencyto.2009.12.002 Ogoh, S., Tzeng, Y-C., Lucas, S. J. E., Galvin, S. D., & Ainslie, P. N. (2010). Influence of baroreflex-mediated tachycardia on the regulation of dynamic cerebral perfusion during acute hypotension in humans. Journal of Physiology, 588(2), 365-371. doi: 10.1113/jphysiol.2009.180844 Rodrigues, E., Chong, K., Holmes, A. R., Cannon, R. D., Ruske, D. R., & Dawes, P. J. D. (2009). An in-vitro device for the assessment of biofilm mediated voice prosthesis damage: How we do it. Clinical Otolaryngology, 34(5), 481-484. doi: 10.1111/j.1749-4486.2009.01996.x Sherif, A., Hasan, M. N., Marits, P., Karlsson, M., Winqvist, O., & Thörn, M. (2010). Feasibility of T-cell-based adoptive immunotherapy in the first 12 patients with advanced urothelial urinary bladder cancer: Preliminary data on a new immunologic treatment based on the sentinel node concept. European Urology, 58(1), 105-111. doi: 10.1016/j. eururo.2009.09.026 Tarr, G. P., Glue, P., & Herbison, P. (2010). Comparative efficacy and acceptability of mood stabilizer and second generation antipsychotic monotherapy for acute mania: A systematic review and meta-analysis. Journal of Affective Disorders, Advance Online Publication. doi: 10.1016/j.jad.2010.11.009 Thomas, K. N., Burgess, K. R., Basnyat, R., Lucas, S. J. E., Cotter, J. D., Fan, J-L., Peebles, K. C., Lucas, R. A. I., & Ainslie, P. N. (2010). Initial orthostatic hypotension at high altitude. High Altitude Medicine & Biology, 11(2), 163-167. doi: 10.1089/ ham.2009.1056 Thomas, K. N., Cotter, J. D., Galvin, S. D., Williams, M. J. A., Willie, C. K., & Ainslie, P. N. (2009). Initial orthostatic hypotension is unrelated to orthostatic tolerance in healthy young subjects. Journal of Applied Physiology, 107(2), 506-517. doi: 10.1152/japplphysiol.91650.2008 Thomas, K. N., Galvin, S. D., Williams, M. J. A., Willie, C. K., & Ainslie, P. N. (2010). Identical pattern of cerebral hypoperfusion during different types of syncope. Journal of Human Hypertension, 24(7), 458-466. doi: 10.1038/ jhh.2009.93 Thompson, A. R., Cooper, J. A., Jones, G. T., Drenos, F., van Bockxmeer, F. M., Biros, E., Walker, P. J., van Rij, A. M., et al. (2010). Assessment of the association between genetic polymorphisms in transforming growth factor beta, and its binding protein (LTBP), and the presence, and expansion, of Abdominal Aortic Aneurysm. Atherosclerosis, 209, 367-373. doi: 10.1016/j.atherosclerosis.2009.09.073 Thomson, I. A., Goh, F., Livingstone, V., & van Rij, A. M. (2009). How safe is open abdominal aortic aneurysm surgery for octogenarians in New Zealand? ANZ Journal of Surgery, 79(5), 344-347. doi: 10.1111/j.1445-2197.2009.04886.x Thorgeirsson, T. E., Gudbjartsson, D. F., Surakka, I., Vink, J. M., ..., Jones, G. T., van Rij, A. M., et al. (2010). Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nature Genetics, 42(5), 448-453. doi: 10.1038/ng.573 Yan, S-L., & Thompson-Fawcett, M. (2009). NOTES: New dimension of minimally invasive surgery. ANZ Journal of Surgery, 79(5), 337-343. doi: 10.1111/j.1445-2197.2009.04885.x

Division of HEALTH SCIENCES 161 Journal - Research Other Galvin, S., Chen, V., Bunton, R., & Doyle, T. (2010). Sutureless pericardial patch augmentation for impending left ventricular free wall rupture [Case report]. Interactive Cardiovascular and Thoracic Surgery, 10, 341-343. doi: 10.1510/ icvts.2009.217125 Galvin, S. D., Sampangi, N. R., Wilson, B. K. J., & Samalia, K. P. (2010). Periurethral abscess: An unusual source of sepsis. ANZ Journal of Surgery, 80(9), 653-654. Galvin, S. D., Wademan, B., Chu, J., & Bunton, R. W. (2010). Benign metastasizing leiomyoma: A rare metastatic lesion in the right ventricle [Case report]. Annals of Thoracic Surgery, 89(1), 279-281. doi: 10.1016/j.athoracsur.2009.06.050 Hanney, R. M., Hill, A. G., LeMaire, S. A., van Rij, A., & Windsor, J. A. (2009). Developing academic surgeons: The focus of a new course. ANZ Journal of Surgery, 79(12), 872-875. Jones, G. T., Deng, M., Hammond-Tooke, G. D., McCormick, S. P. A., & van Rij, A. M. (2009). Increased plasma lipoprotein(a) found in large-artery atherosclerotic, but not small-artery occlusive, stroke [Letter to the editor]. Clinical Chemistry, 55(10), 1888-1890. doi: 10.1373/clinchem.2009.126771 Jones, G. T., & van Rij, A. M. (2009). Regarding ‘Identification of a genetic variant associated with abdominal aortic aneurysms on chromosome 3p12.3 by genome wide association’ [Letter to the editor]. Journal of Vascular Surgery, 50(5), 1246-1247. doi: 10.1016/j.jvs.2009.07.098 McCall, J., & Connor, J. (2010). Systematic reviews in public health research [Editorial]. Australian and New Zealand Journal of Public Health, 34(4), 343-344. doi: 10.1111/j.1753-6405.2009.00562.x Rodrigues, E., Chong, K., Holmes, A. R., Cannon, R. D., Ruske, D. R., & Dawes, P. J. D. (2009). An in-vitro device for the assessment of biofilm mediated voice prosthesis damage: How we do it [Letter to the editor]. Clinical Otolaryngology, 34(5), 481-484. doi: 10.1111/j.1749-4486.2009.01996.x van Rij, A. M. (2009). Building the surgical workforce through our medical schools [Editorial]. ANZ Journal of Surgery, 79(4), 217-218. doi: 10.1111/j.1445-2197.2009.04844.x

Dunedin School of Medicine Department of Pathology

Journal - Research Article Anjomshoaa, A., Nasri, S., Humar, B., McCall, J. L., Chatterjee, A., Yoon, H-S., McNoe, L., Black, M. A., & Reeve, A. E. (2009). Slow proliferation as a biological feature of colorectal cancer metastasis. British Journal of Cancer, 101(5), 822-828. doi: 10.1038/sj.bjc.6605229 Bell, C. G., Finer, S., Lindgren, C. M., ..., Morison, I. M., et al. (2010). Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO Type 2 diabetes and obesity susceptibility locus. PLoS ONE, 5(11), e14040. doi: 10.1371/journal.pone.0014040 Cohen, S. B., Ma, W., Valova, V. A., Algie, M., Harfoot, R., Woolley, A. G., Robinson, P. J., & Braithwaite, A. W. (2010). Genotoxic stress-induced nuclear localization of oncoprotein YB-1 in the absence of proteolytic processing. Oncogene, 29, 403-410. doi: 10.1038/onc.2009.321 Dias, G. J., Peplow, P. V., McLaughlin, A., Teixeira, F., & Kelly, R. J. (2010). Biocompatibility and osseointegration of reconstituted keratin in an ovine model. Journal of Biomedical Materials Research, 92A(2), 513-520. doi: 10.1002/ jbm.a.32394 Fitches, A. C., Yousem, S., Cieply, K., Stebbings, S., Highton, J., & Hung, N. A. (2010). PCR detectable Y chromosome-specific DNA but no intact Y chromosome-bearing cells in polymyositis biopsies of two women with male offspring. Pathology, 42(2), 160-164. doi: 10.3109/00313020903494953 Fukuzawa, R., Anaka, M. R., Weeks, R. J., Morison, I. M., & Reeve, A. E. (2009). Canonical WNT signalling determines lineage specificity in Wilms tumour. Oncogene, 28(8), 1063-1075. doi: 10.1038/onc.2008.455 Gould, M. L., Williams, G., & Nicholson, H. D. (2010). Changes in caveolae, caveolin, and polymerase 1 and transcript release factor (PTRF) expression in prostate cancer progression. Prostate, Advance Online Publication. doi: 10.1002/pros.21195 Hancox, R. J., Poulton, R., Welch, D., Olova, N., McLachlan, C. R., Greene, J. M., Sears, M. R., Caspi, A., Moffitt, T. E., Robertson, S. P., & Braithwaite, A. W. (2009). Accelerated decline in lung function in cigarette smokers is associated with TP53/MDM2 polymorphisms. Human Genetics, 126(4), 559-565. doi: 10.1007/s00439-009-0704-z Harkins, C., Hammond-Tooke, G., & Faed, J. (2009). Intravenous immunoglobulin therapy for neurological disorders. New Zealand Medical Journal, 122(1305). Retrieved from http://www.nzma.org.nz/journal/122-1305/3850/ Hibma, M. H., Real, N. C., Wiles, A., Dobson-Le, D., Dix, B. R., Wynford-Thomas, D., Braithwaite, A. W., & Royds, J. A. (2009). Increased apoptosis and reduced replication efficiency of the E3 region-modified dl309 adenovirus in cancer cells. Virus Research, 145(1), 112-120. doi: 10.1016/j.virusres.2009.06.016 Hueber, P-A., Fukuzawa, R., Elkares, R., Chu, L., Blumentkrantz, M., He, S-J., Anaka, M. R., Reeve, A. E., Eccles, M. R., Jabado, N., Iglesias, D., & Goodyer, P. R. (2009). PAX3 is expressed in the stromal compartment of the developing kidney and in Wilms tumors with myogenic phenotype. Pediatric and Developmental Pathology, 12(5), 347-354. doi: 10.2350/08-05-0466.1 Huschtscha, L., Moore, J. D., Noble, J. R., Campbell, H. G., Royds, J. A., Braithwaite, A. W., & Reddel, R. R. (2009). Normal human mammary epithelial cells proliferate rapidly in the presence of elevated levels of the tumor suppressors p53 and p21WAF1/CIP1. Journal of Cell Science, 122(16), 2989-2995. doi: 10.1242/jcs.044107

162 RESEARCH REPORT 2009/2010 Jeffs, A. R., Glover, A. C., Slobbe, L. J., Wang, L., He, S., Hazlett, J. A., Awasthi, A., Woolley, A. G., Marshall, E. S., Joseph, W. R., Print, C. G., Baguley, B. C., & Eccles, M. R. (2009). A gene expression signature of invasive potential in metastatic melanoma cells. PLoS ONE, 4(12), e8461. doi: 10.1371/journal.pone.0008461 Jenkins, Z. A., van Kogelenberg, M., Morgan, T., Jeffs, A., Fukuzawa, R., Pearl, E., ..., & Robertson, S. P. (2009). Germline mutations in WTX cause a sclerosing skeletal dysplasia but do not predispose to tumorigenesis. Nature Genetics, 41(1), 95-100. doi: 10.1038/ng.270 Jiang, W. Q., Zhong, Z-H., Nguyen, A., Henson, J. D., Toouli, C. D., Braithwaite, A. W., & Reddel, R. (2009). Induction of alternative lengthening of telomeres-associated PML bodies by p53/p21 requires HP1 proteins. Journal of Cell Biology, 185(5), 797-810. doi: 10.1083/jcb.200810084 Joshi, S., Perera, S., Gilbert, J., ..., Braithwaite, A. W., et al. (2010). The dynamin inhibitors MiTMAB and OcTMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells. Molecular Cancer Therapeutics, 9(7), 1995-2006. doi: 10.1158/1535-7163.MCT-10-0161 Kirana, C., Ward, T., Jordan, T. W., Rawson, P., Royds, J., Shi, H. J., Stubbs, R., & Hood, K. (2009). Compatibility of toluidine blue with laser microdissection and saturation labeling DIGE. Proteomics, 9(2), 485-490. doi: 10.1002/pmic.200800197 Ledgerwood, E. C., & Morison, I. M. (2009). Targeting the apoptosome for cancer therapy. Clinical Cancer Research, 15(2), 420-424. doi: 10.1158/1078-0432.CCR-08-1172 Leong, C-M. (Jimmy), Doorbar, J., Nindl, I., Yoon, H-S., & Hibma, M. H. (2010). Deregulation of E-cadherin by human papillomavirus is not confined to high-risk, cancer-causing types. British Journal of Dermatology, 163(6), 1253-1263. doi: 10.1111/j.1365-2133.2010.09968.x Leong, C-M. (Jimmy), Doorbar, J., Nindl, I., Yoon, H-S., & Hibma, M. H. (2010). Loss of epidermal Langerhans cells occurs in human papillomavirus a, g, and m but not b genus infections. Journal of Investigative Dermatology, 130(2), 472-480. doi: 10.1038/jid.2009.266 Macartney-Coxson, D. P., Hood, K. A., Shi, H-j., Ward, T., Wiles, A. K., ..., Royds, J. A., et al. (2009). Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein level. BMC Cancer, 8(187). Retrieved from http://www.biomedcentral.com/1471-2407/8/187 McDonald, K. L., McDonnell, J., Muntoni, A., Henson, J. D., Hegi, M. E., ..., & Royds, J. A. (2010). Presence of alternative lengthening of telomeres mechanism in patients with glioblastoma identifies a less aggressive tumor type with longer survival. Journal of Neuropathology and Experimental Neurology, 69(7), 729-736. doi: 10.1097/NEN.0b013e3181e576cf Mönnich, M., Banks, S., Eccles, M., Dickinson, E., & Horsfield, J. (2009). Expression of cohesin and condensin genes during zebrafish development supports a non-proliferative role for cohesin. Gene Expression Patterns, 9(8), 586-594. doi: 10.1016/j.gep.2009.08.004 Mönnich, M., Hess, I., Wiest, W., Bachrati, C., Hickson, I. D., et al. (2010). Developing T lymphocytes are uniquely sensitive to a lack of topoisomerase III alpha. European Journal of Immunology, 40(9), 2379-2384. doi: 10.1002/eji.201040634 Peplow, P. V., Dias, G. J., Teixeira, F., & Kelly, R. J. (2009). Tissue reaction to matrices of reconstituted keratin polymer implanted subcutaneously in sheep. Journal of Biomedical Materials Research, 89A(1), 255-265. doi: 10.1002/jbm.a.32038 Reversade, B., Escande-Beillard, N., Dimopoulou, A., ..., Markie, D., Gray, M., Robertson, S., et al. (2009). Mutations in PYCR1 cause cutis laxa with progeroid features. Nature Genetics, 41(9), 1016-1021. doi: 10.1038/ng.413 Rhodes, J. M., Bentley, F. K., Print, C. G., Dorsett, D., Misulovin, Z., Dickinson, E. J., Crosier, K. E., Crosier, P. S., & Horsfield, J. A. (2010). Positive regulation of c-Myc by cohesin is direct, and evolutionarily conserved. Developmental Biology, 344, 637-649. doi: 10.1016/j.ydbio.2010.05.493 Sheard, P. W., Bewick, G. S., Woolley, A. G., Shaw, J., Fisher, L., Fong, S. W., & Duxson, M. J. (2010). Investigation of neuromuscular abnormalities in neurotrophin-3-deficient mice. European Journal of Neuroscience, 31(1), 29-41. doi: 10.1111/j.1460-9568.2009.07032.x Slatter, T., Gifford-Garner, J., Wiles, A., Tan, X., Chen, Y-J., MacFarlane, M., Sullivan, M., Royds, J., & Hung, N. (2010). Pilocytic astrocytomas have telomere-associated promyelocytic leukemia bodies without alternatively lengthened telomeres. American Journal of Pathology, 177(6), 2694-2700. doi: 10.2353/ajpath.2010.100468 Slatter, T. L., Ganesan, P., Holzhauer, C., Mehta, R., Rubio, C., Williams, G., Wilson, M., Royds, J. A., Baird, M. A., & Braithwaite, A. W. (2010). p53-mediated apoptosis prevents the accumulation of progenitor B cells and B-cell tumors. Cell Death and Differentiation, 17, 540-550. doi: 10.1038/cdd.2009.136 Vincent, A. L., Markie, D. M., De Karolyi, B., Wheeldon, C. E., & Patel, D. V. (2009). Exclusion of known corneal dystrophy genes in an autosomal dominant pedigree of a unique anterior membrane corneal dystrophy. Molecular Vision, 15(182), 1700-1708. Weeks, R. J., Kees, U. R., Song, S., & Morison, I. M. (2010). Silencing of TESTIN by dense biallelic promoter methylation is the most common molecular event in childhood acute lymphoblastic leukaemia. Molecular Cancer, 9, 163. doi: 10.1186/1476- 4598-9-163 Zou, D., Yoon, H-S., Anjomshoaa, A., Perez, D., Fukuzawa, R., Guilford, P., & Humar, B. (2009). Increased levels of active c-Src distinguish invasive from in situ lobular lesions. Breast Cancer Research, 11(4), R45. doi: 10.1186/bcr2332 Zou, D., Yoon, H-S., Perez, D., Weeks, R. J., Guilford, P., & Humar, B. (2009). Epigenetic silencing in non-neoplastic epithelia identifies E-cadherin (CDH1) as a target for chemoprevention of lobular neoplasia. Journal of Pathology, 218(2), 265-272. doi: 10.1002/path.2541

Division of HEALTH SCIENCES 163 Journal - Research Other He, S., Yoon, H-S., Suh, B-J., & Eccles, M. R. (2010). PAX3 is extensively expressed in benign and malignant tissues of the melanocytic lineage in humans [Letter]. Journal of Investigative Dermatology, 130, 1465-1468. doi: 10.1038/jid.2009.434 Sherwin, C. M. T., Svahn, S., Van Der Linden, A., Broadbent, R. S., Medlicott, N. J., & Reith, D. M. (2009). Individualised dosing of amikacin in neonates: A pharmacokinetic/pharmacodynamic analysis. European Journal of Clinical Pharmacology, 65(7), 705-713. doi: 10.1007/s00228-009-0637-4

Dunedin School of Medicine Department of Preventive and Social Medicine

Authored Book - Research Gauld, R. (2009). Revolving doors: New Zealand’s health reforms: The continuing saga (2nd ed.). Wellington, New Zealand: Health Services Research Centre, Institute of Policy Studies, 259p. Gauld, R. (2009). The new health policy. Maidenhead, UK: Open University Press, 201p. Hale, B., Barrett, P., & Gauld, R. (2010). The age of supported independence: Voices of in-home care. Dordrecht, The Netherlands: Springer, 131p.

Edited Book - Other Signal, L., Egan, R., & Cook, L. (Eds.). (2009). Reviews of health promotion practice in Aotearoa New Zealand 2007-2008. Auckland, New Zealand: Health Promotion Forum of New Zealand & Health Promotion and Policy Unit, University of Otago, 138p.

Chapter in Book - Research Davis, P., Lin, V., & Gauld, R. (2009). Public health in Australia and New Zealand. In R. Beaglehole & R. Bonita (Eds.), Global public health: A new era (2nd ed.). (pp. 225-247). Oxford University Press. Gauld, R. (2009). ‘E-government’: Is it the next big public sector trend? In S. F. Goldfinch, & J. L. Wallis (Eds.), International handbook of public management reform (pp. 105-120). Cheltenham, UK: Edward Elgar. Gauld, R. (2009). Health and health care in post-industrial society. In J. Powell & J. Hendricks (Eds.), The welfare state in post- industrial society: A global perspective (pp. 125-140). Dordrecht, The Netherlands: Springer. Hoek, J., & McLean, R. (2010). Changing food environment and obesity: An overview. In J. Pearce & K. Witten (Eds.), Geographies of obesity: Environmental understandings of the obesity epidemic (pp. 57-78). Farnham, UK: Ashgate.

Journal - Research Article Abbott, J. H., Robertson, M. C., McKenzie, J. E., Baxter, G. D., Theis, J-C., Campbell, A. J., & the MOA Trial Team (2009). Exercise therapy, manual therapy, or both, for osteoarthritis of the hip or knee: A factorial randomised controlled trial protocol. Trials, 10(11). doi: 10.1186/1745-6215-10-11 Adetifa, I. M. O., Ota, M. O. C., Jeffries, D. J., Hammond, A., ..., & Hill, P. C. (2010). Commercial interferon gamma release assays compared to the tuberculin skin test for diagnosis of latent Mycobacterium tuberculosis infection in childhood contacts in The Gambia. Pediatric Infectious Disease Journal, 29(5), 439-443. doi: 10.1097/INF.0b013e3181cb45da Aiello, A. E., Coulborn, R. M., Aragon, T. G., Baker, M. G., Burrus, B. B., Cowling, B., Duncan, A., ..., Priest, P., et al. (2010). Research findings from nonpharmaceutical intervention studies for pandemic influenza and current gaps in the research. American Journal of Infection Control, 38(4), 251-258. doi: 10.1016/j.ajic.2009.12.007 Alber, S. A., & Weiss, R. E. (2009). A model selection approach to analysis of variance and covariance. Statistics in Medicine, 28, 1821-1840. doi: 10.1002/sim.3595 Al-Shaqsi, S. Z. K. (2010). Response time as a sole performance indicator in EMS: Pitfalls and solutions. Open Access Emergency Medicine, 2, 1-6. Aylward, L. L., Bodner, K. M., Collins, J. J., Wilken, M., McBride, D., et al. (2010). TCDD exposure estimation for workers at a New Zealand 2,4,5-T manufacturing facility based on serum sampling data. Journal of Exposure Science & Environmental Epidemiology, 20(5), 417-426. doi: 10.1038/jes.2009.31 Beasley, M., Fisher, P., O’Connor, C., & Eason, C. (2009). Sodium fluoroacetate (1080): Assessment of occupational exposures and selection of a provisional biological exposure index. New Zealand Medical Journal, 122(1302). Retrieved from http:// www.nzma.org.nz/journal/122-1302/3771/ Beatty, S., Stevens, W., Stevens, G., Kolbe, J., & Cox, B. (2009). Lung cancer patients in New Zealand initially present to secondary care through the emergency department rather than by referral to a respiratory specialist. New Zealand Medical Journal, 122(1294). Retrieved from http://www.nzma.org.nz/journal/122-1294/3584 Begg, D., Langley, J., Brookland, R., McDowell, A., Ameratunga, S., & Broughton, J. (2009). The opinions of newly licensed drivers in New Zealand on the minimum car driver licensing age and reasons for getting a licence. New Zealand Medical Journal, 122(1306). Retrieved from http://www.nzma.org.nz/journal/122-1306/3880/ Begg, D., Langley, J., Broughton, J., Brookland, R., Ameratunga, S., & McDowell, A. (2009). New Zealand drivers study: A follow-up study of newly licensed drivers. Injury Prevention, 15(4), e2. doi: 10.1136/ip.2009.021998

164 RESEARCH REPORT 2009/2010 Bell, M. L., van Roode, T., Dickson, N. P., Jiang, Z-J., & Paul, C. (2010). Consistency and reliability of self-reported lifetime number of heterosexual partners by gender and age in a cohort study. Sexually Transmitted Diseases, 37(7), 425-431. doi: 10.1097/OLQ.0b013e3181d13ed8 Black, G. F., Thiel, B. A., Ota, M. O., ..., Hill, P. C., et al. (2009). Immunogenicity of novel DosR regulon-encoded candidate antigens of Mycobacterium tuberculosis in three high-burden populations in Africa. Clinical and Vaccine Immunology, 16(8), 1203-1212. doi: 10.1128/CVI.00111-09

Boulet, L-P., Hancox, R. J., & Fitch, K. D. (2010). Exercise and asthma: b2-agonists and the competitive athlete. Breathe, 7(1), 65-71. doi: 10.1183/18106838.0701.064 Bracewell, L. M., Campbell, D. I., Faure, P. R., Giblin, E. R., Morris, T. A., Satterthwaite, L. B., Simmers, C. D. A., Ulrich, C. M., & Holmes, J. D. (2010). Sickness presenteeism in a New Zealand hospital. New Zealand Medical Journal, 123(1314). Retrieved from http://www.nzmj.org/journal/123-1314/ Bradbury, K. E., Skeaff, C. M., Green, T. J., Gray, A. R., & Crowe, F. L. (2010). Serum fatty acids myristic acid and linoleic acid are better predictors of serum cholesterol concentrations when measured as molecular percentages rather than as absolute concentrations. American Journal of Clinical Nutrition, 91, 398-405. doi: 10.3945/ajcn.2009.28159 Bradshaw, A. J., Horwath, C. C., Katzer, L., & Gray, A. (2010). Non-dieting group interventions for overweight and obese women: What predicts non-completion and does completion improve outcomes? Public Health Nutrition, 13(10), 1622- 1628. doi: 10.1017/S1368980009992977 Broughton, J. (2010). An oral health intervention for the Mäori Indigenous population of New Zealand: Oranga niho Mäori (Mäori oral health) as a component of the undergraduate dental curriculum in New Zealand. International Dental Journal, 60(3), 223-228. doi: 10.1922/IDJ_2567Broughton06 Buckingham, K. J., & Devlin, N. J. (2009). A note on the nature of utility in time and health and implications for cost utility analysis. Social Science and Medicine, 68(2), 362-367. doi: 10.1016/j.socscimed.2008.09.048 Burns, C. J., Collins, J. J., Humphry, N., Bodner, K. M., Aylward, L. L., & McBride, D. (2010). Correlates of serum dioxin to self- reported exposure factors. Environmental Research, 110(2), 131-136. doi: 10.1016/j.envres.2009.11.003 Bussey, M. D., Bell, M. L., & Milosavljevic, S. (2009). The influence of hip abduction and external rotation on sacroiliac motion. Manual Therapy, 14(5), 520-525. doi: 10.1016/j.math.2008.08.009 Bussey, M. D., Milosavljevic, S., & Bell, M. L. (2009). Sex differences in the pattern of innominate motion during passive hip abduction and external rotation. Manual Therapy, 14(5), 514-519. doi: 10.1016/j.math.2008.09.004 Cameron, S. L., McLay-Cooke, R. T., Brown, R. C., Gray, A. R., & Fairbairn, K. A. (2010). Increased blood pH but not performance with sodium bicarbonate supplementation in elite rugby union players. International Journal of Sport Nutrition and Exercise Metabolism, 20(4), 307-321. Cao, J., Lee, J. J., & Alber, S. (2009). Comparison of Bayesian sample size criteria: ACC, ALC, and WOC. Journal of Statistical Planning and Inference, 139, 4111-4122. doi: 10.1016/j.jspi.2009.05.041 Capstick, S., Norris, P., Sopoaga, F., & Tobata, W. (2009). Relationships between health and culture in Polynesia: A review. Social Science and Medicine, 68(7), 1341-1348. doi: 10.1016/j.socscimed.2009.01.002 Chu, J. W., Wong, C-K., Chambers, J., Vant Wout, J., Herbison, P., & Tang, E. W. (2010). Aspirin resistance determined from a bed-side test in patients suspected to have acute coronary syndrome portends a worse 6 months outcome. QJM, 103, 405- 412. doi: 10.1093/qjmed/hcq038 Clarke, J. F., van Rumste, M. M. E., Farquhar, C. M., Johnson, N. P., Mol, B. W. J., & Herbison, P. (2010). Measuring outcomes in fertility trials: Can we rely on clinical pregnancy rates? Fertility and Sterility, 94(5), 1647-1651. doi: 10.1016/j. fertnstert.2009.11.018 Collins, J. J., Wilken, M., McBride, D., Humphry, N. F., Herbison, P., Burns, C. J., & Bodner, K. (2009). Serum concentrations of chlorinated dibenzo-p-dioxins and dibenzofurans among former New Zealand trichlorophenol workers. Chemosphere, 76(11), 1550-1556. doi: 10.1016/j.chemosphere.2009.05.037 Connor, J., Gray, A., & Kypri, K. (2010). Drinking history, current drinking and problematic sexual experiences among university students. Australian and New Zealand Journal of Public Health, 34(5), 487-494. doi: 10.1111/j.1753- 6405.2010.00595.x Connor, J. L., Kypri, K., Bell, M. L., & Cousins, K. (2010). Alcohol outlet density, levels of drinking and alcohol-related harm in New Zealand: A national study. Journal of Epidemiology and Community Health, Advance Online Publication. doi: 10.1136/ jech.2009.104935 Coppell, K. J., Anderson, K., Williams, S. M., Lamb, C., Farmer, V. L., & Mann, J. I. (2010). The quality of diabetes care: A comparison between patients enrolled and not enrolled on a regional diabetes register. Primary Care Diabetes, Advance Online Publication. doi: 10.1016/j.pcd.2010.10.005 Coppell, K. J., Kataoka, M., Williams, S. M., Chisholm, A. W., Vorgers, S. M., & Mann, J. I. (2010). Nutritional intervention in patients with type 2 diabetes who are hyperglycaemic despite optimised drug treatment: Lifestyle over and above drugs in diabetes (LOADD) study: Randomised controlled trial. BMJ, 341, c3337. doi: 10.1136/bmj.c3337 Coppell, K. J., Tipene-Leach, D. C., Pahau, H. L. R., Williams, S. M., Abel, S., Iles, M., Harre Hindmarsh, J., & Mann, J. I. (2009). Two-year results from a community-wide diabetes prevention intervention in a high risk indigenous community: The Ngati and Healthy Project. Diabetes Research and Clinical Practice, 85(2), 220-227. doi: 10.1016/j.diabres.2009.05.009 Cousins, K., Connor, J. L., & Kypri, K. (2010). Reducing alcohol-related harm and social disorder in a university community: A framework for evaluation. Injury Prevention, 16(5), e1-e6. doi: 10.1136/ip.2010.027961

Division of HEALTH SCIENCES 165 Cox, B., Ballard-Barbash, R., Broeders, M., Dowling, E., Malila, N., Shumak, R., Taplin, S., Buist, D., & Miglioretti, D. (2010). Recording of hormone therapy and breast density in breast screening programs: Summary and recommendations of the International Cancer Screening Network. Breast Cancer Research and Treatment, Advance Online Publication. doi: 10.1007/s10549-010-0893-0 Cox, B., Richardson, A., Graham, P., Gislefoss, R. E., Jellum, E., & Rollag, H. (2010). Breast cancer, cytomegalovirus and Epstein-Barr virus: A nested case-control study. British Journal of Cancer, 102, 1665-1669. doi: 10.1038/sj.bjc.6605675 Crocombe, L. A., Broadbent, J. M., Thomson, W. M., Brennan, D. S., Slade, G. D., & Poulton, R. (2010). Dental visiting trajectory patterns and their antecedents. Journal of Public Health Dentistry, Advance Online Publication. doi: 10.1111/j.1752-7325.2010.00196.x Cross, A. J., Heath, A-L. M., Ferguson, E. L., Gray, A. R., & Szymlek-Gay, E. A. (2009). Rates of common communicable illnesses in non-anaemic 12-24 month old South Island, New Zealand children. New Zealand Medical Journal, 122(1290). Retrieved from http://www.nzma.org.nz/journal/122-1290/3489/ Cunningham, R., Carter, K., Connor, J., & Fawcett, J. (2010). Does health status matter for the risk of injury? New Zealand Medical Journal, 123(1327). Retrieved from http://www.nzma.org.nz/journal/123-1327/4479/ Dale, K. S., Mann, J. I., McAuley, K. A., Williams, S. M., & Farmer, V. L. (2009). Sustainability of lifestyle changes following an intensive lifestyle intervention in insulin resistant adults: Follow-up at 2-years. Asia Pacific Journal of Clinical Nutrition, 18(1), 114-120. Dale, K. S., McAuley, K. A., Taylor, R. W., Williams, S. M., Farmer, V. L., Hansen, P., Vorgers, S. M., Chisholm, A. W., & Mann, J. I. (2009). Determining optimal approaches for weight maintenance: A randomized controlled trial. CMAJ, 180(10), E39-E46. doi: 10.1503/cmaj.080974 Danese, A., Moffitt, T. E., Harrington, H., Milne, B. J., Polanczyk, G., Pariante, C. M., Poulton, R., & Caspi, A. (2009). Adverse childhood experiences and adult risk factors for age-related disease: Depression, inflammation, and clustering of metabolic risk markers. Archives of Pediatrics and Adolescent Medicine, 163(12), 1135-1143. Davidson, P. L., Wilson, S. J., Chalmers, D. J., Wilson, B. D., & McBride, D. (2009). Examination of interventions to prevent common lower-limb injuries in the New Zealand Defense Force. Military Medicine, 174(11), 1196-1202. de Jong, B. C., Adetifa, I., Walther, B., Hill, P. C., Antonio, M., Ota, M., & Adegbola, R. A. (2010). Differences between tuberculosis cases infected with Mycobacterium africanum, West African type 2, relative to Euro-American Mycobacterium tuberculosis: An update. FEMS Immunology and Medical Microbiology, 58(1), 102-105. doi: 10.1111/j.1574- 695X.2009.00628.x Dennison, J., Batra, A., & Herbison, P. (2009). The maxillary artery and the lateral pterygoid muscle: The New Zealand story. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 108(5), e26-e29. doi: 10.1016/j. tripleo.2009.07.029 Derrett, S., Bevin, T. H., Herbison, P., & Paul, C. (2009). Access to elective surgery in New Zealand: Considering equity and the private and public mix. International Journal of Health Planning and Management, 24(2), 147-160. doi: 10.1002/hpm.978 Derrett, S., Black, J., & Herbison, G. P. (2009). Outcome after injury: A systematic literature search of studies using the EQ-5D. Journal of Trauma, 67(4), 883-890. doi: 10.1097/TA.0b013e3181ae6409 Derrett, S., Darmody, M., Williams, S., Rutherford, M., Schollum, J., & Walker, R. (2010). Older peoples’ satisfaction with home-based dialysis. Nephrology, 15(4), 464-470. doi: 10.1111/j.1440-1797.2010.01286.x Dickson, N. P., Ryding, J., van Roode, T., Paul, C., Herbison, P., Dillner, J., & Skegg, D. C. G. (2009). Male circumcision and serologically determined human papillomavirus infection in a birth cohort. Cancer Epidemiology Biomarkers and Prevention, 18(1), 177-183. doi: 10.1158/1055-9965.EPI-08-0353 Dite, G. S., Whittemore, A. S., Knight, J. A., John, E. M., Milne, R. L., Andrulis, I. L., Southey, M. C., McCredie, M. R. E., et al. (2010). Increased cancer risks for relatives of very early-onset breast cancer cases with and without BRCA1 and BRCA2 mutations. British Journal of Cancer, 103(7), 1103-1108. doi: 10.1038/sj.bjc.6605876 Dummer, J. F., Epton, M. J., Cowan, J. O., Cook, J. M., Condliffe, R., Landhuis, C. E., Smith, A. D., & Taylor, D. R. (2009). Predicting corticosteroid response in chronic obstructive pulmonary disease using exhaled nitric oxide. American Journal of Respiratory and Critical Care Medicine, 180(9), 846-852. doi: 10.1164/rccm.200905-0685OC Duncan, A. R., Priest, P. C., Jennings, L. C., Brunton, C. R., & Baker, M. G. (2009). Screening for influenza infection in international airline travelers. American Journal of Public Health, 99(Suppl. 2), S360-S362. doi: 10.2105/AJPH.2008.158071 Fairhall, T. J., Thomson, M. W., Kieser, J. A., Broughton, J. R., Cullinan, M. P., & Seymour, G. J. (2009). Home or away? Differences between home- and clinic-based dental examinations for older people. Gerodontology, 26(3), 179-186. doi: 10.1111/j.1741-2358.2008.00263.x Farah, R., Drummond, B. K., Swain, M., & Williams, S. (2010). Linking the clinical presentation of molar-incisor hypomineralisation to its mineral density. International Journal of Paediatric Dentistry, 20(5), 353-360. doi: 10.1111/j.1365- 263X.2010.01061.x Firth, H., Herbison, P., & McGee, R. (2009). Stress and health among New Zealand farmers. Journal of Occupational Health and Safety - Australia and New Zealand, 25(2), 89-97. Retrieved from http://www.scopus.com/inward/record.url?eid=2-s2.0- 67649592385&partnerID=40 Freeman, C., & Quigg, R. (2009). Children’s lives: A Dunedin study. Childrenz Issues, 13(1), 35-42. Freeman, C., & Quigg, R. (2009). Commuting lives: Children’s mobility and energy use. Journal of Environmental Planning and Management, 52(3), 393-412. doi: 10.1080/09640560802703280

166 RESEARCH REPORT 2009/2010 Fullana, M. A., Mataix-Cols, D., Caspi, A., Harrington, H., Grisham, J. R., Moffitt, T. E., & Poulton, R. (2009). Obsessions and compulsions in the community: Prevalence, interference, help-seeking, developmental stability, and co-occurring psychiatric conditions. American Journal of Psychiatry, 166(3), 329-336. doi: 10.1176/appi.ajp.2008/08071006 Gale, C., Hannah, A., Swain, N., Gray, A., Coverdale, J., & Oud, N. (2009). Patient aggression perceived by community support workers. Australasian Psychiatry, 17(6), 497-501. doi: 10.1080/10398560903287516 Galland, B. C., Tripp, E. G., Gray, A., & Taylor, B. J. (2010). Apnea-hypopnea indices and snoring in children diagnosed with ADHD: A matched case-control study. Sleep Breath, Advance Online Publication. doi: 10.1007/s11325-010-0357-0 Gaudet, M. M., Milne, R. L., Cox, A., Breast Cancer Association Consortium, & including McCredie, M. R. E. (2009). Five polymorphisms and breast cancer risk: Results from the Breast Cancer Association Consortium. Cancer Epidemiology Biomarkers & Prevention, 18(5), 1610-1616. doi: 10.1158/1055-9965.epi-08-0745 Gauld, R. (2009). Improving New Zealand’s health system performance: Challenges for the way forward. Eurohealth, 15(3), 32-35. Gauld, R. (2010). Are elected health boards an effective mechanism for public participation in health service governance? Health Expectations, 13(4), 369-378. doi: 10.1111/j.1369-7625.2010.00605.x Gauld, R. (2010). Big country, small country: How the United States debated health reform while New Zealand just got on with it. International Journal of Clinical Practice, 64(10), 1334-1336. doi: 10.1111/j.1742-1241.2010.02477.x Gauld, R., Goldfinch, S., & Horsburgh, S. (2010). Do they want it? Do they use it? The ‘demand-side’ of e-government in Australia and New Zealand. Government Information Quarterly, 27(2), 177-186. doi: 10.1016/j.giq.2009.12.002 Gauld, R., Gray, A., & McComb, S. (2009). How responsive is e-government? Evidence from Australia and New Zealand. Government Information Quarterly, 26(1), 69-74. doi: 10.1016/j.giq.2008.02.002 Gauld, R., Horwitt, J., Williams, S., & Cohen, A. B. (2010). What strategies do US hospitals employ to reduce unwarranted clinical practice variations? American Journal of Medical Quality, Advance Online Publication. doi: 10.1177/1062860610375107 Gauld, R., & Williams, S. (2009). Use of the internet for health information: A study of Australians and New Zealanders. Informatics for Health and Social Care, 34(3), 149-158. doi: 10.1080/17538150903102448 Glazener, C., Wilson, D., MacArthur, C., Lancashire, R., & Herbison, P. (2009). Randomised controlled trial (RCT) of conservative management of postnatal urinary and faecal incontinence: Twelve year follow up. International Urogynecology Journal, 20(Suppl. 2), S79. doi: 10.1007/s00192-009-0896-8 Godley, R., Brown, R. C., Williams, S. M., & Green, T. J. (2009). Moderate alcohol consumption the night before glycaemic index testing has no effect on glycaemic response. European Journal of Clinical Nutrition, 63(5), 692-694. doi: 10.1038/ ejcn.2008.27 Goldfinch, S., Gauld, R., & Herbison, P. (2009). The participation divide? Political participation, trust in government, and e-government in Australia and New Zealand. Australian Journal of Public Administration, 68(3), 333-350. doi: 10.1111/j.1467-8500.2009.00643.x Gordon, R. C., Rose, M. C., Skeaff, S. A., Gray, A. R., Morgan, K. M. D., & Ruffman, T. (2009). Iodine supplementation improves cognition in mildly iodine-deficient children. American Journal of Clinical Nutrition, 90(5), 1264-1271. doi: 10.3945/ajcn.2009.28145 Goulding, A., Taylor, R. W., Grant, A. M., Jones, S., Taylor, B. J., & Williams, S. (2009). Relationships of appendicular LMI and total body LMI to bone mass and physical activity levels in a birth cohort of New Zealand five-year olds. Bone, 45, 455- 459. doi: 10.1016/j.bone.2009.05.007 Goulding, A., Taylor, R. W., Grant, A. M., Parnell, W. R., Wilson, N., Wilson, N. C., & Williams, S. M. (2010). Waist-to-height ratios in relation to BMI z-scores in three ethnic groups from a representative sample of New Zealand children aged 5-14 years. International Journal of Obesity, 34, 1188-1190. doi: 10.1038/ijo.2009.278 Green, T. J., Skeaff, C. M., McMahon, J. A., Venn, B. J., Williams, S. M., Devlin, A. M., & Innis, S. M. (2010). Homocysteine- lowering vitamins do not lower plasma S-adenosylhomocysteine in older people with elevated homocysteine concentrations. British Journal of Nutrition, 103(11), 1629-1634. doi: 10.1017/S0007114509993552 Gregory, A. M., Caspi, A., Moffitt, T. E., Milne, B. J., Poulton, R., & Sears, M. R. (2009). Links between anxiety and allergies: Psychobiological reality or possible methodological bias? Journal of Personality, 77(2), 347-361. doi: 10.1111/j.1467- 6494.2008.00550.x Gregory, A. M., Caspi, A., Moffitt, T. E., & Poulton, R. (2009). Sleep problems in childhood predict neuropsychological functioning in adolescence. Pediatrics, 123(4), 1171-1176. doi: 10.1542/peds.2008-0825 Gregory, J., Thomson, W. M., Broughton, J. R., Cullinan, M. P., Seymour, G. J., Kieser, J. A., Donaghy, M-A., & Shearer, D. M. (2010). Experiences and perceptions of oral health and oral health care among a sample of older New Zealanders. Gerodontology, Advance Online Publication. doi: 10.1111/j.1741-2358.2010.00402.x Grisham, J. R., Anderson, T. M., Poulton, R., Moffitt, T. E., & Andrews, G. (2009). Childhood neuropsychological deficits associated with adult obsessive-compulsive disorder. British Journal of Psychiatry, 195(2), 138-141. doi: 10.1192/bjp. bp.108.056812 Gulliver, P., Chalmers, D., & Cousins, K. (2009). Achieving compliance with pool fencing legislation in New Zealand: How much progress has been made in 10 years? International Journal of Injury Control and Safety Promotion, 16(3), 127-132. doi: 10.1080/17457300903024004 Guo, H. J., McGee, R., Reeder, T., & Gray, A. (2010). Smoking behaviours and contextual influences on adolescent nicotine dependence. Australian and New Zealand Journal of Public Health, 34(5), 502-507. doi: 10.1111/j.1753-6405.2010.00597.x

Division of HEALTH SCIENCES 167 Hale, L., Miller, R., Barach, A., Skinner, M., & Gray, A. (2009). Motor Control Test responses to balance perturbations in adults with an intellectual disability. Journal of Intellectual & Developmental Disability, 34(1), 81-86. Hammond, V., Reeder, A. I., & Gray, A. (2009). Patterns of real-time occupational ultraviolet radiation exposure among a sample of outdoor workers in New Zealand. Public Health, 123(2), 182-187. doi: 10.1016/j.puhe.2008.12.007 Hancox, R. J., Le Souëf, P. N., Anderson, G. P., Reddel, H. K., Chang, A. B., & Beasley, R. (2010). Asthma: Time to confront some inconvenient truths. Respirology, 15(2), 194-201. doi: 10.1111/j.1440-1843.2009.01700.x Hancox, R. J., Poulton, R., Ely, M., Welch, D., Taylor, D. R., McLachlan, C. R., Greene, J. M., Moffitt, T. E., Caspi, A., & Sears, M. R. (2010). Effects of cannabis on lung function: A population-based cohort study. European Respiratory Journal, 35(1), 42-47. doi: 10.1183/09031936.00065009 Hancox, R. J., Poulton, R., Greene, J. M., McLachlan, C. R., Pearce, M. S., & Sears, M. R. (2009). Associations between birth weight, early childhood weight gain and adult lung function. Thorax, 64(3), 228-232. Hancox, R. J., Poulton, R., Welch, D., Olova, N., McLachlan, C. R., Greene, J. M., Sears, M. R., Caspi, A., Moffitt, T. E., Robertson, S. P., & Braithwaite, A. W. (2009). Accelerated decline in lung function in cigarette smokers is associated with TP53/MDM2 polymorphisms. Human Genetics, 126(4), 559-565. doi: 10.1007/s00439-009-0704-z Harcombe, H., McBride, D., Derrett, S., & Gray, A. (2009). Prevalence and impact of musculoskeletal disorders in New Zealand nurses, postal workers and office workers. Australian and New Zealand Journal of Public Health, 33(5), 437-441. doi: 10.1111/j.1753-6405.2009.00425.x Harcombe, H., McBride, D., Derrett, S., & Gray, A. (2010). Physical and psychosocial risk factors for musculoskeletal disorders in New Zealand nurses, postal workers and office workers. Injury Prevention, 16(2), 96-100. doi: 10.1136/ip.2009.021766 Harrison-Woolrych, M., & Ashton, J. (2010). Utilization of the smoking cessation medicine varenicline: An intensive post- marketing study in New Zealand. Pharmacoepidemiology and Drug Safety, 19(9), 949-953. doi: 10.1002/pds.2003 Harrison-Woolrych, M., Ashton, J., & Herbison, P. (2010). Fatal and non-fatal cardiovascular events in a general population prescribed sibutramine in New Zealand: A prospective cohort study. Drug Safety, 33(7), 605-613. doi: 10.2165/11532440- 000000000-00000 Hashim, R., Williams, S. M., & Thomson, W. M. (2009). Diet and caries experience among preschool children in Ajman, United Arab Emirates. European Journal of Oral Sciences, 117(6), 734-740. doi: 10.1111/j.1600-0722.2009.00688.x Hashim, R., Williams, S. M., Thomson, W. M., & Awad, M. A. (2010). Caries prevalence and intra-oral pattern among young children in Ajman. Community Dental Health, 27(2), 109-113. doi: 10.1922/CDH_2428Hashim05 Hendrick, P., Bell, M. L., Bagge, P. J., & Milosavljevic, S. (2009). Can accelerometry be used to discriminate levels of activity? Ergonomics, 52(8), 1019-1025. doi: 10.1080/00140130902846464 Hendrick, P., Milosavljevic, S., Bell, M. L., Hale, L., Hurley, D. A., McDonough, S. M., Melloh, M., & Baxter, G. D. (2009). Does physical activity change predict functional recovery in low back pain? Protocol for a prospective cohort study. BMC Musculoskeletal Disorders, 10, 136. doi: 10.1186/1471-2474-10-136 Herbison, G. P., & Arnold, E. P. (2009). Sacral neuromodulation with implanted devices for urinary storage and voiding dysfunction in adults. Cochrane Database of Systematic Reviews, 2, CD004202. doi: 10.1002/14651858.CD004202.pub2 Herbison, P., Hay-Smith, J., & Gillespie, W. J. (2010). Meta-analyses of small numbers of trials often agree with longer-term results. Journal of Clinical Epidemiology, Advance Online Publication. doi: 10.1016/j.jclinepi.2010.02.017 Herbison, P., Hay-Smith, J., Paterson, H., Ellis, G., & Wilson, D. (2009). Research priorities in urinary incontinence: Results from citizens’ juries. BJOG, 116(5), 713-718. doi: 10.1111/j.1471-0528.2008.02093.x Hewitt, R. S., Modrich, C. M., Cowan, J. O., Herbison, G. P., & Taylor, D. R. (2009). Outcomes using exhaled nitric oxide measurements as an adjunct to primary care asthma management. Primary Care Respiratory Journal, 18(4), 320-327. doi: 10.4104/pcrj.2009.00060 Heydon, E. E., Thomson, C. D., Mann, J., Williams, S. M., Skeaff, S. A., Sherpa, K. T., & Heydon, J. L. (2009). Iodine status in a Sherpa community in a village of the Khumbu region of Nepal. Public Health Nutrition, 12(9), 1431-1436. Higgins, J., Nairn, K., & Sligo, J. (2009). Alternative ways of expressing and reading identity. Ethnography and Education, 4(1), 83-99. doi: 10.1080/17457820802703549 Higgins, J., Nairn, K., & Sligo, J. (2010). Vocational imagination and labour market literacy: Young New Zealanders making education-employment linkages. Journal of Vocational Education & Training, 62(1), 13-25. doi: 10.1080/13636820903491716 Hill, P. C., & Ota, M. O. C. (2010). Tuberculosis case-contact research in endemic tropical settings: Design, conduct, and relevance to other infectious diseases. Lancet Infectious Diseases, 10(10), 723-732. doi: 10.1016/S1473-3099(10)70164-X Hill, P. C., Townend, J., Antonio, M., Akisanya, B., Ebruke, C., Lahai, G., Greenwood, B. M., & Adegbola, R. A. (2010). Transmission of Streptococcus pneumoniae in rural Gambian villages: A longitudinal study. Clinical Infectious Diseases, 50(11), 1468-1476. doi: 10.1086/652443 Hill, S. E., Njie, O., Sanneh, M., ..., Hill, P. C., et al. (2009). Oxygen for treatment of severe pneumonia in The Gambia, West Africa: A situational analysis. International Journal of Tuberculosis and Lung Disease, 13(5), 587-593. Holmes, J. D., & Simmons, G. C. (2009). Gastrointestinal illness associated with a long-haul flight. Epidemiology and Infection, 137(3), 441-447. Horsburgh-McLeod, G. F., Gray, A. R., Reeder, A. I., & McGee, R. (2010). Applying Item Response Theory (IRT) to a suntan attitudes scale. Australasian Epidemiologist, 17(1), 40-46. Horsburgh-McLeod, G., Latner, J. D., & O’Brien, K. S. (2009). Unprompted generation of obesity stereotypes. Eating and Weight Disorders, 14(2-3), e153-e157.

168 RESEARCH REPORT 2009/2010 Horsburgh, S., Norris, P., Becket, G., Crampton, P., Arroll, B., Cumming, J. M., Herbison, P., & Sides, G. (2010). The Equity in Prescription Medicines Use study: Using community pharmacy databases to study medicines utilisation. Journal of Biomedical Informatics, Advance Online Publication. doi: 10.1016/j.jbi.2010.08.004 Houghton, L. A., Szymlek-Gay, E. A., Gray, A. R., Ferguson, E. L., Deng, X., & Heath, A-L. M. (2010). Predictors of vitamin D status and its association with parathyroid hormone in young New Zealand children. American Journal of Clinical Nutrition, 92(1), 69-76. doi: 10.3945/ajcn.2009.29055 Howie, S. R. C., Hill, S., Ebonyi, A., ..., Hill, P. C., et al. (2009). Meeting oxygen needs in Africa: An options analysis from the Gambia. Bulletin of the World Health Organization, 87(10), 763-771. doi: 10.2471/blt.08.058370 Hutton, L., Frame, R., Maggo, H., Shirakawa, H., Mulligan, H., Waters, D., & Hale, L. (2009). The perceptions of physical activity in an elderly population at risk of falling: A focus group study. New Zealand Journal of Physiotherapy, 37(2), 85-92. Ioannidis, J. P. A., Loy, E. Y., Poulton, R., & Chia, K. S. (2009). Researching genetic versus nongenetic determinants of disease: A comparison and proposed unification. Science Translational Medicine, 1(7), 7ps8. doi: 10.1126/scitranslmed.3000247 Jenks, K., Meikle, G., Gray, A., & Stebbings, S. (2009). Osteitis condensans ilii: A significant association with sacroiliac joint tenderness in women. International Journal of Rheumatic Diseases, 12(1), 39-43. doi: 10.1111/j.1756-185X.2009.01378.x Jenks, K., Stebbings, S., Burton, J., Schultz, M., Herbison, G. P., & Highton, J. (2010). Probiotic therapy for the treatment of spondyloarthritis: A randomized controlled trial. Journal of Rheumatology, Advance Online Publication. doi: 10.3899/ jrheum.100193 Jenks, K., Treharne, G. J., Garcia, J., & Stebbings, S. (2010). The Ankylosing Spondylitis Quality of Life Questionnaire: Validation in a New Zealand cohort. International Journal of Rheumatic Diseases, 13(4), 361-366. doi: 10.1111/j.1756- 185X.2010.01554.x Jones, L. M., Waters, D. L., & Legge, M. (2009). Walking speed at self-selected exercise pace is lower but energy cost higher in older versus younger women. Journal of Physical Activity and Health, 6(3), 327-332. José, M. V., Govezensky, T., García, J. A., & Bobadilla, J. R. (2009). On the evolution of the standard genetic code: Vestiges of critical scale invariance from the RNA world in current prokaryote genomes. PLoS ONE, 4(2), e4340. doi: 10.1371/journal. pone.0004340 Kidd, M. O., Bond, C. H., & Bell, M. L. (2010). Patients’ perspectives of patient-centredness as important in musculoskeletal physiotherapy interactions: A qualitative study. Physiotherapy, Advance Online Publication. doi: 10.1016/j. physio.2010.08.002 Kieser, J. A., Dall’Alba, G., & Livingstone, V. (2009). Impact of curriculum on understanding of professional practice: A longitudinal study of students commencing dental education. Advances in Health Sciences Education, 14(3), 303-314. doi: 10.1007/s10459-008-9114-6 Kinaston, R. L., Buckley, H. R., Halcrow, S. E., Spriggs, M. J. T., Bedford, S., Neal, K., & Gray, A. (2009). Investigating foetal and perinatal mortality in prehistoric skeletal samples: A case study from a 3000-year-old Pacific Island cemetery site. Journal Of Archaeological Science, 36(12), 2780-2787. doi: 10.1016/j.jas.2009.09.004 Koenen, K. C., Moffitt, T. E., Roberts, A. L., Martin, L. T., Kubzansky, L., Harrington, H., Poulton, R., & Caspi, A. (2009). Childhood IQ and adult mental disorders: A test of the cognitive reserve hypothesis. American Journal of Psychiatry, 166(1), 50-57. Kotsimbos, T., Waterer, G., Jenkins, C., Kelly, P. M., Cheng, A., Hancox, R. J., ..., & Thoracic Society of Australia and New Zealand H1N1 Influenza 09 Task Force (2010). Influenza A/H1N1_09: Australia and New Zealand’s winter of discontent. American Journal of Respiratory and Critical Care Medicine, 181(4), 300-306. doi: 10.1164/rccm.200912-1878CP Kunac, D. L., Kennedy, J., Austin, N. C., & Reith, D. M. (2010). Risk factors for adverse drug events and medication errors in paediatric inpatients: Analysis by admission characteristics. Journal of Pharmacy Practice and Research, 40(4), 290-293. Kunac, D. L., Kennedy, J., Austin, N., & Reith, D. (2009). Incidence, preventability, and impact of adverse drug events (ADEs) and potential ADEs in hospitalized children in New Zealand: A prospective observational cohort study. Pediatric Drugs, 11(2), 153-160. doi: 10.2165/00148581-200911020-00005 Kunac, D. L., & Tatley, M. V. (2010). Detecting medication errors in the New Zealand Pharmacovigilance Database: A retrospective analysis. Drug Safety, 34(1), 59-71. doi: 10.2165/11539290-000000000-00000 Kypri, K., Paschall, M. J., Langley, J., Baxter, J., Cashell-Smith, M., & Bourdeau, B. (2009). Drinking and alcohol-related harm among New Zealand university students: Findings from a national web-based survey. Alcoholism: Clinical and Experimental Research, 33(2), 307-314. doi: 10.1111/j.1530-0277.2008.00834.x Kypri, K., Paschall, M. J., Langley, J. D., Baxter, J., & Bourdeau, B. (2010). The role of drinking locations in university student drinking: Findings from a national web-based survey. Drug and Alcohol Dependence, 111, 38-43. doi: 10.1016/j. drugalcdep.2010.03.018 Leon de la Barra, S., Redman, S., & Eades, S. (2009). Health research policy: A case study of policy change in Aboriginal and Torres Strait Islander health research. Australia and New Zealand Health Policy, 6(2). doi: 10.1186/1743-8462-6-2 Leon de la Barra, S., Redman, S., Eades, S., & Lonsdale, C. (2009). A decade of NHMRC People Support expenditure in review: Is support for indigenous health research increasing? Medical Journal of Australia, 190(1), 28-31. Lester, P. E., Weiss, R. E., Rice, E., Comulada, W. S., Lord, L., Alber, S., & Rotheram-Borus, M. J. (2009). The longitudinal impact of HIV+ parents’ drug use on their adolescent children. American Journal of Orthopsychiatry, 79(1), 51-59. doi: 10.1037/a0015427 Lovell, S. A. (2009). Social capital: The panacea for community? Geography Compass, 3(2), 781-796. doi: 10.1111/j.1749- 8198.2008.00208.x

Division of HEALTH SCIENCES 169 Lovell, S. A., & Rosenberg, M. W. (2009). Community capacity amongst people living with HIV/AIDS. GeoJournal, Advance Online Publication. doi: 10.1007/s10708-009-9289-2 Lugos, M. D., Adetifa, I. M. O., Donkor, S., Hill, P. C., Adegbola, R. A., & Ota, M. O. C. (2009). Evaluation of the contribution of major T cell subsets to IFN-g production in TB infection by ELISPOT. Immunological Investigations, 38(5), 341-349. doi: 10.1080/08820130902748744 MacDonald, A. A., Herbison, G. P., Showell, M., & Farquhar, C. M. (2010). The impact of body mass index on semen parameters and reproductive hormones in human males: A systematic review with meta-analysis. Human Reproduction Update, 16(3), 293-311. doi: 10.1093/humupd/dmp047 MacInnis, R. J., Antoniou, A. C., Eeles, R. A., ..., McCredie, M. R., et al. (2010). Prostate cancer segregation analyses using 4390 families from UK and Australian population-based studies. Genetic Epidemiology, 34(1), 42-50. doi: 10.1002/gepi.20433 MacKenzie, G., Ceesay, S. J., Hill, P. C., Walther, M., Bojang, K. A., et al. (2010). A decline in the incidence of invasive non- typhoidal Salmonella infection in the Gambia temporally associated with a decline in malaria infection. PLoS ONE, 5(5), e10568. doi: 10.1371/journal.pone.0010568 Mainvil, L. A., Horwath, C. C., McKenzie, J. E., & Lawson, R. (2010). Validation of brief instruments to measure adult fruit and vegetable consumption. Appetite, Advance Online Publication. doi: 10.1016/j.appet.2010.09.008 Mainvil, L. A., Lawson, R., Horwath, C. C., McKenzie, J. E., & Hart, I. (2010). Validated scales to assess adult decisional balance to eat more fruits and vegetables. Appetite, Advance Online Publication. doi: 10.1016/j.appet.2010.08.007 Mainvil, L. A., Lawson, R., Horwath, C. C., McKenzie, J. E., & Reeder, A. I. (2009). Validated scales to assess adult self-efficacy to eat fruits and vegetables. American Journal of Health Promotion, 23(3), 210-217. Mandhane, P. J., Sears, M. R., Poulton, R., Greene, J. M., Lou, W. Y. W., Taylor, D. R., & Hancox, R. J. (2009). Cats and dogs and the risk of atopy in childhood and adulthood. Journal of Allergy and Clinical Immunology, 124(4), 745-750. doi: 10.1016/j. jaci.2009.06.038 Marsh, L., McGee, R., Nada-Raja, S., & Williams, S. (2010). Text bullying and traditional bullying among New Zealand secondary school students. Journal of Adolescence, 33(1), 237-240. doi: 10.1016/j.adolescence.2009.06.001 Marsh, L., Williams, S., & McGee, R. (2009). Teachers’ perceptions of physical aggression among secondary school students: A New Zealand view. Australian Journal of Education, 53(3), 245-260. McAuley, K. A., Taylor, R. W., Farmer, V. L., Hansen, P., Williams, S. M., Booker, C. S., & Mann, J. I. (2010). Economic evaluation of a community-based obesity prevention program in children: The APPLE project. Obesity, 18(1), 131-136. doi: 10.1038/oby.2009.148 McBride, D. I., Burns, C. J., Herbison, G. P., Humphry, N. F., Bodner, K., & Collins, J. J. (2009). Mortality in employees at a New Zealand agrochemical manufacturing site. Occupational Medicine, 59(4), 255-263. doi: 10.1093/occmed/kqp030 McBride, D. I., Collins, J. J., Humphry, N. F., Herbison, G. P., Bodner, K. M., Aylward, L. L., Burns, C. J., & Wilken, M. (2009). Mortality in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin at a trichlorophenol plant in New Zealand. Journal of Occupational and Environmental Medicine, 51(9), 1049-1056. doi: 10.1097/JOM.0b013e3181b571ae McCool, J. P., Reeder, A. I., Robinson, E. M., Petrie, K. J., & Gorman, D. F. (2009). Outdoor workers’ perceptions of the risks of excess sun-exposure. Journal of Occupational Health, 51(5), 404-411. McCredie, M. R. E., Paul, C., Sharples, K. J., Baranyai, J., Medley, G., Skegg, D. C. G., & Jones, R. W. (2010). Consequences in women of participating in a study of the natural history of cervical intraepithelial neoplasia 3. Australian and New Zealand Journal of Obstetrics and Gynaecology, 50(4), 363-370. doi: 10.1111/j.1479-828X.2010.01170.x McDowell, A., Begg, D., Connor, J., & Broughton, J. (2009). Unlicensed driving among urban and rural Mäori drivers: New Zealand drivers study. Traffic Injury Prevention, 10(6), 538-545. doi: 10.1080/15389580903321727 McGee, R., Williams, S., & Kypri, K. (2010). College students’ readiness to reduce binge drinking: Criterion validity of a brief measure. Drug and Alcohol Dependence, 109, 236-238. doi: 10.1016/j.drugalcdep.2009.12.009 McKenzie, J. E., Herbison, G. P., Roth, P., & Paul, C. (2010). Obstacles to researching the researchers: A case study of the ethical challenges of undertaking methodological research investigating the reporting of randomised controlled trials. Trials, 11(28). doi: 10.1186/1745-6215-11-28 McKenzie, J. E., Priest, P., Audas, R., Poore, M. R., Brunton, C. R., & Reeves, L. M. (2010). Hand sanitisers for reducing illness absences in primary school children in New Zealand: A cluster randomised controlled trial study protocol. Trials, 11, 7. doi: 10.1186/1745-6215-11-7 Menon, K. C., Skeaff, S. A., Thomson, C. D., Gray, A. R., Ferguson, E. L., Zodpey, S., Saraf, A., et al. (2010). Concurrent micronutrient deficiencies are prevalent in nonpregnant rural and tribal women from central India. Nutrition, Advance Online Publication. doi: 10.1016/j.nut.2010.02.012 Millar, E., Baker, M. G., Howden-Chapman, P., Wilson, N., & Dickson, N. (2009). Involving students in real-world research: A pilot study for teaching public health and research skills. BMC Medical Education, 9. doi: 10.1186/1472-6920-9-45 Milne, B. J., Caspi, A., Crump, R., Poulton, R., Rutter, M., Sears, M. R., & Moffitt, T. E. (2009). The validity of the family history screen for assessing family history of mental disorders. American Journal of Medical Genetics, Part B, 150B(1), 41-49. doi: 10.1002/ajmg.b.30764 Milne, B. J., Caspi, A., Harrington, H., Poulton, R., Rutter, M., & Moffitt, T. E. (2009). Predictive value of family history on severity of illness: The case for depression, anxiety, alcohol dependence, and drug dependence. Archives of General Psychiatry, 66(7), 738-747. doi: 10.1001/archgenpsychiatry.2009.55 Miranda, C. L., Reed, R. L., Kuiper, H. C., Alber, S., & Stevens, J. F. (2009). Ascorbic acid promotes detoxification and elimination of 4-hydroxy-2(E)-nonenal in human monocytic THP-1 cells. Chemical Research in Toxicology, 22(5), 863- 874. doi: 10.1016/j.jspi.2009.05.041

170 RESEARCH REPORT 2009/2010 Moffitt, T. E., Caspi, A., Taylor, A., Kokaua, J., Milne, B. J., Polanczyk, G., & Poulton, R. (2010). How common are common mental disorders? Evidence that lifetime prevalence rates are doubled by prospective versus retrospective ascertainment. Psychological Medicine, 40(6), 899-909. doi: 10.1017/s0033291709991036 Moore, A. E., Jeffery, R., Gray, A., & Stringer, M. D. (2010). An anatomical ultrasound study of the long posterior sacro-iliac ligament. Clinical Anatomy, Advance Online Publication. doi: 10.1002/ca.21039 Morgan, E. J., Heath, A-L. M., Szymlek-Gay, E. A., Gibson, R. S., Gray, A. R., Bailey, K. B., & Ferguson, E. L. (2010). Red meat and a fortified manufactured toddler milk drink increase dietary zinc intakes without affecting zinc status of New Zealand toddlers. Journal of Nutrition, 140(12), 2221-2226. doi: 10.3945/jn.109.120717 Mouchawar, J., Korch, C., Byers, T., Pitts, T. M., Li, E., McCredie, M. R. E., et al. (2010). Population-based estimate of the contribution of TP53 mutations to subgroups of early-onset breast cancer: Australian Breast Cancer Family Study. Cancer Research, 70(12), 4795-4800. doi: 10.1158/0008-5472.can-09-0851 Mulrine, H. M., Skeaff, S. A., Ferguson, E. L., Gray, A. R., & Valeix, P. (2010). Breast-milk iodine concentration declines over the first 6 mo postpartum in iodine-deficient women. American Journal of Clinical Nutrition, Advance Online Publication. doi: 10.3945/ajcn.2010.29630 Newsham-West, R. J., Marley, J., Schneiders, A. G., & Gray, A. (2010). Pre-race health status and medical events during the 2005 World Adventure Racing Championships. Journal of Science and Medicine in Sport, 13(1), 27-31. doi: 10.1016/j. jsams.2008.07.007 Nielsen, G., Taylor, R., Williams, S., & Mann, J. (2010). Permanent play facilities in school playgrounds as a determinant of children’s activity. Journal of Physical Activity and Health, 7(4), 490-496. Ning, B., Brown, R. C., Venn, B. J., Williams, S. M., & Green, T. J. (2010). The effect of the fat and carbohydrate contents in the evening meal preceding GI testing on GI. European Journal of Clinical Nutrition, 64, 224-226. doi: 10.1038/ejcn.2009.133 Pai, M., Joshi, R., Dogra, S., ..., Hill, P. C., et al. (2009). T-cell assay conversions and reversions among household contacts of tuberculosis patients in rural India. International Journal of Tuberculosis and Lung Disease, 13(1), 84-92. Parker, E. J., Jamieson, L. M., Broughton, J., Albino, J., Lawrence, H. P., & Roberts-Thomson, K. (2010). The oral health of indigenous children: A review of four nations. Journal of Paediatrics and Child Health, 46(9), 483-486. doi: 10.1111/j.1440- 1754.2010.01847.x Parkin, L., Williams, S. M., & Priest, P. (2009). Preventing winter falls: A randomised controlled trial of a novel intervention. New Zealand Medical Journal, 122(1298). Retrieved from http://www.nzma.org.nz/journal/122-1298/3683/ Patel, A., Gauld, R., Norris, P., & Rades, T. (2010). ²This body does not want free medicines²: South African consumer perceptions of drug quality. Health Policy and Planning, 25(1), 61-69. doi: 10.1093/heapol/czp039 Patel, A., Norris, P., Gauld, R., & Rades, T. (2009). Drug quality in South Africa: Perceptions of key players involved in medicines distribution. International Journal of Health Care Quality Assurance, 22(5), 547-560. doi: 10.1108/09526860910975643 Paterson, H., Ashton, J. A., & Harrison-Woolrych, M. (2009). A nationwide cohort study of the use of the levonorgestrel intrauterine device in New Zealand adolescents. Contraception, 79(6), 433-438. doi: 10.1016/j.contraception.2008.12.001 Paul, C., van Roode, T., Herbison, P., & Dickson, N. (2009). Longitudinal study of self-reported sexually transmitted infection incidence by gender and age up to age thirty-two years. Sexually Transmitted Diseases, 36(2), 63-69. Perry, S., de Jong, B. C., Solnick, J. V., ..., Hill, P. C., et al. (2010). Infection with Helicobacter pylori is associated with protection against tuberculosis. PLoS ONE, 5(1), e8804. doi: 10.1371/journal.pone.0008804 Pogoda, J. M., Preston-Martin, S., Howe, G., ..., McCredie, M. R. E., et al. (2009). An international case-control study of maternal diet during pregnancy and childhood brain tumor risk: A histology-specific analysis by food group. Annals of Epidemiology, 19(3), 148-160. doi: 10.1016/j.annepidem.2008.12.011 Polanczyk, G., Caspi, A., Williams, B., Price, T. S., Danese, A., Sugden, K., Uher, R., Poulton, R., & Moffitt, T. E. (2009). Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment replication and extension. Archives of General Psychiatry, 66(9), 978-985. Priest, P., Sadler, L., Sykes, P., Marshall, R., Peters, J., & Crengle, S. (2010). Determinants of inequalities in cervical cancer stage at diagnosis and survival in New Zealand. Cancer Causes and Control, 21, 209-214. doi: 10.1007/s10552-009-9451-7 Prosser, N. R., Heath, A-L. M., Williams, S. M., & Gibson, R. S. (2010). Influence of an iron intervention on the zinc status of young adult New Zealand women with mild iron deficiency. British Journal of Nutrition, 104, 742-750. doi: 10.1017/ S0007114510001091 Qalo Qoqonokana, M., Brian, G., Ramke, J., Garcia, J., & Szetu, J. (2010). Diabetic retinopathy in a hospital eye clinic population in Honiara, Solomon Islands. Clinical and Experimental Ophthalmology, Advance Online Publication. doi: 10.1111/j.1442-9071.2010.02356.x Quigg, R., Gray, A., Reeder, A. I., Holt, A., & Waters, D. L. (2010). Using accelerometers and GPS units to identify the proportion of daily physical activity located in parks with playgrounds in New Zealand children. Preventive Medicine, 50, 235-240. doi: 10.1016/j.ypmed.2010.02.002 Rasmussen, F., Mikkelsen, D., Hancox, R. J., Lambrechtsen, J., Nybo, M., Hansen, H. S., & Siersted, H. C. (2009). High-sensitive C-reactive protein is associated with reduced lung function in young adults. European Respiratory Journal, 33(2), 382-388. doi: 10.1183/09031936.00040708 Reeder, A. I., Hammond, V. A., & Gray, A. R. (2010). Questionnaire items to assess skin color and erythemal sensitivity: Reliability, validity, and ²the dark shift². Cancer Epidemiology, Biomarkers and Prevention, 19(5), 1167-1173. doi: 10.1158/1055-9965.EPI-09-1300

Division of HEALTH SCIENCES 171 Reeder, A. I., Jopson, J. A., & Gray, A. (2009). Baseline survey of sun protection policies and practices in primary school settings in New Zealand. Health Education Research, 24(5), 778-787. doi: 10.1093/her/cyp013 Richards, R., McGee, R., Williams, S. M., Welch, D., & Hancox, R. J. (2010). Adolescent screen time and attachment to parents and peers. Archives of Pediatrics and Adolescent Medicine, 164(3), 258-262. doi: 10.1001/archpediatrics.2009.280 Richards, R., Murdoch, L., Reeder, A. I., & Rosenby, M. (2010). Advocacy for active transport: Advocate and city council perspectives. International Journal of Behavioral Nutrition and Physical Activity, 7. doi: 10.1186/1479-5868-7-5 Richards, R., Poulton, R., Reeder, A. I., & Williams, S. (2009). Childhood and contemporaneous correlates of adolescent leisure time physical inactivity: A longitudinal study. Journal of Adolescent Health, 44(3), 260-267. doi: 10.1016/j. jadohealth.2008.08.005 Rose, D., Quick, A., Swain, M., & Herbison, P. (2009). Moment-to-force characteristics of preactivated nickel-titanium and titanium-molybdenum alloy symmetrical T-loops. American Journal of Orthodontics and Dentofacial Orthopedics, 135(6), 757-763. doi: 10.1016/j.ajodo.2007.06.015 Rutherford, M., Alisjahbana, B., Maharani, W., Sampurno, H., van Crevel, R., & Hill, P. C. (2010). Sensitivity of the Quantiferon-Gold in-tube assay in sputum smear positive TB cases in Indonesia. PLoS ONE, 5(8), e12020. doi: 10.1371/ journal.pone.0012020 Rutherford, M., Dockerty, J. D., Jasseh, M., Howie, S. R. C., Herbison, P., ..., & Hill, P. C. (2009). Preventive measures in infancy to reduce under-five mortality: A case-control study in The Gambia. Tropical Medicine and International Health, 14(2), 149-155. doi: 10.1111/j.1365-3156.2008.02204.x Rutherford, M. E., Dockerty, J. D., Jasseh, M., Howie, S. R. C., Herbison, P., Jeffries, D. J., ..., & Hill, P. C. (2009). Access to health care and mortality of children under 5 years of age in the Gambia: A case-control study. Bulletin of the World Health Organization, 87(3), 216-224. doi: 10.2471/BLT.08.052175 Rutherford, M. E., Mulholland, K., & Hill, P. C. (2010). How access to health care relates to under-five mortality in sub- Saharan Africa: Systematic review. Tropical Medicine & International Health, 15(5), 508-519. doi: 10.1111/j.1365- 3156.2010.02497.x Savage, R. L., Kunac, D. L., & Johansson, J. (2009). Appraising the post-marketing safety of medicines: A description of national and international pharmacovigilance with a focus on medicines used in chronic pain. Current Anaesthesia and Critical Care, 20(5-6), 215-220. doi: 10.1016/j.cacc.2009.07.013 Schep, L. J., Slaughter, R. J., & Beasley, D. M. G. (2009). Nicotinic plant poisoning. Clinical Toxicology, 47(8), 771-781. doi: 10.1080/15563650903252186 Schep, L. J., Slaughter, R. J., & Beasley, D. M. G. (2010). The clinical toxicology of metamfetamine. Clinical Toxicolology, 48(7), 675-694. doi: 10.3109/15563650.2010.516752 Schep, L. J., Slaughter, R. J., Becket, G., & Beasley, D. M. G. (2009). Poisoning due to water hemlock. Clinical Toxicology, 47(4), 270-278. doi: 10.1080/15563650902904332 Schep, L. J., Slaughter, R. J., Temple, W. A., & Beasley, D. M. G. (2009). Diethylene glycol poisoning. Clinical Toxicology, 47(6), 525-535. doi: 10.1080/15563650903086444 Schneiders, A. G., Sullivan, S. J., Gray, A. R., Hammond-Tooke, G. D., & McCrory, P. R. (2010). Normative values for three clinical measures of motor performance used in the neurological assessment of sports concussion. Journal of Science and Medicine in Sport, 13(2), 196-201. doi: 10.1016/j.jsams.2009.05.004 Schultz, M., Davidson, A., Donald, S., Targonska, B., Turnbull, A., Weggery, S. E., Livingstone, V., & Dockerty, J. D. (2009). Gastroenterology service in a teaching hospital in rural New Zealand, 1991-2003. World Journal of Gastroenterology, 15(5), 583-590. doi: 10.3748/wjg.15.583 Sehgal, P., Sopoaga, F., & Beresford, R. (2009). Bridging the gap: Strategies to promote the recruitment and retention of Pacific Islanders into the health professions. New Zealand Medical Students Journal, 9, 5-8. Shah, V. O., Scariano, J., Waters, D., Qualls, C., Morgan, M., Pickett, G., et al. (2009). Mitochondrial DNA deletion and sarcopenia. Genetics in Medicine, 11(3), 147-152. Skegg, K., Firth, H., Gray, A., & Cox, B. (2010). Suicide by occupation: Does access to means increase the risk? Australian and New Zealand Journal of Psychiatry, 44(5), 429-434. doi: 10.3109/00048670903487191 Skegg, K., & Herbison, P. (2009). Effect of restricting access to a suicide jumping site. Australian and New Zealand Journal of Psychiatry, 43(6), 498-502. Skegg, K., Nada-Raja, S., Dickson, N., & Paul, C. (2010). Perceived ²out of control² sexual behavior in a cohort of young adults from the Dunedin Multidisciplinary Health and Development Study. Archives of Sexual Behavior, 39, 968-978. doi: 10.1007/s10508-009-9504-8 Sligo, J., Rothstein, D., Buxton, J., Salter, G., & Hancox, R. (2009). How do researchers do it? A description of developing a multidisciplinary research assessment. Childrenz Issues, 13(1), 21-29. Sneyd, M. J., & Cox, B. (2009). Melanoma in Maori, Asian, and Pacific Peoples in New Zealand. Cancer Epidemiology Biomarkers and Prevention, 18(6), 1706-1713. doi: 10.1158/1055-9965.EPI-08-0682 Sopoaga, F., Buckingham, K., & Paul, C. (2010). Causes of excess hospitalizations among Pacific peoples in New Zealand: Implications for primary care. Journal of Primary Health Care, 2(2), 105-110. Stebbings, S., Herbison, P., Doyle, T. C. A., Treharne, G. J., & Highton, J. (2010). A comparison of fatigue correlates in rheumatoid arthritis and osteoarthritis: Disparity in associations with disability, anxiety and sleep disturbance. Rheumatology, 49(2), 361-367. doi: 10.1093/rheumatology/kep367

172 RESEARCH REPORT 2009/2010 Stevens, G., Stevens, W., Purchuri, S., Kolbe, J., & Cox, B. (2009). Radiotherapy utilisation in lung cancer in New Zealand: Disparities with optimal rates explained. New Zealand Medical Journal, 122(1306). Retrieved from http://www.nzma.org. nz/journal/archive.shtml Stevens, J. F., Reed, R. L., Alber, S., Pritchett, L., & Machado, S. (2009). Herbicidal activity of glucosinolate degradation products in fermented meadowfoam (Limnanthes alba) seed meal. Journal of Agricultural and Food Chemistry, 57, 1821- 1826. doi: 10.1021/jf8033732 Stewart, J. H., Vajdic, C. M., van Leeuwen, M. T., Amin, J., Webster, A. C., Chapman, J. R., McDonald, S. P., Grulich, A. E., & McCredie, M. R. E. (2009). The pattern of excess cancer in dialysis and transplantation. Nephrology, Dialysis, Transplantation, 24(10), 3225-3231. doi: 10.1093/ndt/gfp331 Sullivan, M., Paul, C. E., Herbison, G. P., Tamou, P., Derrett, S., & Crawford, M. (2010). A longitudinal study of the life histories of people with spinal cord injury. Injury Prevention, 16(6). doi: 10.1136/ip.2010.028134 Sullivan, S. J., Bourne, L., Choie, S., Eastwood, B., Isbister, S., McCrory, P., & Gray, A. (2009). Understanding of sport concussion by the parents of young rugby players: A pilot study. Clinical Journal of Sport Medicine, 19(3), 228-230. Sutherland, T. J. T., & Hancox, R. J. (2010). Author response to Leptin, adiponectin, and asthma: Findings from a population- based cohort study [Letter]. Annals of Allergy, Asthma & Immunology, 104(4), 355-356. doi: 10.1016/j.anai.2010.02.009 Sutherland, T. J. T., Sears, M. R., McLachlan, C. R., Poulton, R., & Hancox, R. J. (2009). Leptin, adiponectin, and asthma: Findings from a population-based cohort study. Annals of Allergy, Asthma and Immunology, 103(2), 101-107. Szymlek-Gay, E. A., Ferguson, E. L., Heath, A-L. M., Gray, A. R., & Gibson, R. S. (2009). Food-based strategies improve iron status in toddlers: A randomized controlled trial. American Journal of Clinical Nutrition, 90, 1541-1551. doi: 10.3945/ ajcn.2009.27588 Tai, E. S., Poulton, R., Thumboo, J., Sy, R., Castillo-Carandang, N., Sritara, P., et al. (2009). An update on cardiovascular disease epidemiology in South East Asia. Rationale and design of the LIFE course study in CARdiovascular disease Epidemiology (LIFECARE). CVD Prevention and Control, 4(2), 93-102. doi: 10.1016/j.cvdpc.2009.02.003 Tannock, G. W., Tiong, I. S., Priest, P., Munro, K., Taylor, C., & Schultz, M. (2010). Testing probiotic strain Escherichia coli Nissle 1917 (MutaflorÒ) for ability to reduce carriage of multi-drug resistant E. coli by elderly residents of long term care facilities. Journal of Medical Microbiology, Advance Online Publication. doi: 10.1099/jmm.0.025874-0 Tarawhiti, L., Waters, D., Goulding, A., Jones, L., & Hale, L. (2009). Sarcopenic-obesity with polypharmacy is associated with gait and balance disturbances in older adults. New Zealand Medical Student Journal, 9, 19-25. Tarr, G. P., Glue, P., & Herbison, P. (2010). Comparative efficacy and acceptability of mood stabilizer and second generation antipsychotic monotherapy for acute mania: A systematic review and meta-analysis. Journal of Affective Disorders, Advance Online Publication. doi: 10.1016/j.jad.2010.11.009 Taylor, D. R., Palmay, R., Cowan, J. O., & Herbison, G. P. (2010). Long term performance characteristics of an electrochemical nitric oxide analyser. Respiratory Medicine, Advance Online Publication. doi: 10.1016/j.rmed.2010.09.001 Taylor, F., Sims, M., Theis, J-C., & Herbison, G. P. (2009). Interventions for treating acute elbow dislocations in adults. Cochrane Database of Systematic Reviews, (3), CD007908. doi: 10.1002/14651858.CD007908 Taylor, R. W., Brooking, L., Williams, S. M., Manning, P. J., Sutherland, W. H., Coppell, K. J., Tipene-Leach, D., Dale, K. S., McAuley, K. A., & Mann, J. I. (2010). Body mass index and waist circumference cutoffs to define obesity in indigenous New Zealanders. American Journal of Clinical Nutrition, 92, 390-397. doi: 10.3945/ajcn.2010.29317 Taylor, R. W., Brown, D., ..., Rose, E. A., Taylor, B. J., Meredith-Jones, K., Treacy, L., Ross, J., & Williams, S. M. (2010). Motivational interviewing for screening and feedback and encouraging lifestyle changes to reduce relative weight in 4-8 year old children: Design of the MInT study. BMC Public Health, 10, 271. doi: 10.1186/1471-2458-10-271 Taylor, R. W., Grant, A. M., Williams, S. M., & Goulding, A. (2010). Sex differences in regional body fat distribution from pre- to postpuberty. Obesity, 18(7), 1410-1416. doi: 10.1038/oby.2009.399 Taylor, R. W., Murdoch, L., Carter, P., Gerrard, D. F., Williams, S. M., & Taylor, B. J. (2009). Longitudinal study of physical activity and inactivity in preschoolers: The FLAME study. Medicine and Science in Sports and Exercise, 41(1), 96-102. Taylor, R. W., Williams, S. M., Grant, A. M., Taylor, B. J., & Goulding, A. (2010). Predictive ability of waist-to-height in relation to adiposity in children is not improved with age and sex-specific values. Obesity, Advance Online Publication. doi: 10.1038/oby.2010.217 Te Morenga, L., Williams, S., Brown, R., & Mann, J. (2010). Effect of a relatively high-protein, high-fiber diet on body composition and metabolic risk factors in overweight women. European Journal of Clinical Nutrition, Advance Online Publication. doi: 10.1038/ejcn.2010.163 Tey, S. L., Brown, R. C., Chisholm, A. W., Delahunty, C. M., Gray, A. R., & Williams, S. M. (2010). Effects of different forms of hazelnuts on blood lipids and a-tocopherol concentrations in mildly hypercholesterolemic individuals. European Journal of Clinical Nutrition, Advance Online Publication. doi: 10.1038/ejcn.2010.200 Theodore, R. F., Thompson, J. M. D., Waldie, K. E., Becroft, D. M. O., Robinson, E., et al. (2009). Determinants of cognitive ability at 7 years: A longitudinal case-control study of children born small-for-gestational age at term. European Journal of Paediatrics, 168, 1217-1224. doi: 10.1007/s00431-008-0913-9 Theodore, R. F., Thompson, J. M. D., Waldie, K. E., Wall, C., Becroft, D. M. O., et al. (2009). Dietary patterns and intelligence in early and middle childhood. Intelligence, 37, 506-513. doi: 10.1016/j.intell.2009.07.001 Thomson, C. D., Campbell, J. M., Miller, J., Skeaff, S. A., & Livingstone, V. (2009). Selenium and iodine supplementation: Effect on thyroid function of older New Zealanders. American Journal of Clinical Nutrition, 90(4), 1038-1046. doi: 10.3945/ ajcn.2009.28190

Division of HEALTH SCIENCES 173 Thomson, I. A., Goh, F., Livingstone, V., & van Rij, A. M. (2009). How safe is open abdominal aortic aneurysm surgery for octogenarians in New Zealand? ANZ Journal of Surgery, 79(5), 344-347. doi: 10.1111/j.1445-2197.2009.04886.x Thomson, W. M., Broadbent, J. M., Locker, D., & Poulton, R. (2009). Trajectories of dental anxiety in a birth cohort. Community Dentistry and Oral Epidemiology, 37(3), 209-219. doi: 10.1111/j.1600-0528.2009.00473.x Thomson, W. M., Williams, S. M., Broadbent, J. M., Poulton, R., & Locker, D. (2010). Long-term dental visiting patterns and adult oral health. Journal of Dental Research, 89(3), 307-311. doi: 10.1177/0022034509356779 Thye, T., Vannberg, F. O., Wong, S. H., ..., Hill, P. C., et al. (2010). Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. Nature Genetics, 42(9), 739-741. doi: 10.1038/ng.639 Tilling, C., Devlin, N. J., Tsuchiya, A., & Buckingham, K. (2010). Protocols for time tradeoff valuations of health states worse than dead: A literature review. Medical Decision Making, 30(5), 610-619. doi: 10.1177/0272989x09357475 Todd, A. S., MacGinley, R. J., Schollum, J. B. W., Johnson, R. J., Williams, S. M., Sutherland, W. H. F., Mann, J. I., & Walker, R. J. (2010). Dietary salt loading impairs arterial vascular reactivity. American Journal of Clinical Nutrition, 91(3), 557-564. doi: 10.3945/ajcn.2009.28645 Tordoff, J. M., Bagge, M. L., Gray, A. R., Campbell, A. J., & Norris, P. T. (2010). Medicine-taking practices in community- dwelling people aged ³75 years in New Zealand. Age and Ageing, 39(5), 574-580. doi: 10.1093/ageing/afq069 Touray, K., Adetifa, I. M., Jallow, A., Rigby, J., Jeffries, D., ..., & Hill, P. C. (2010). Spatial analysis of tuberculosis in an urban West African setting: Is there evidence of clustering? Tropical Medicine and International Health, 15(6), 664-672. doi: 10.1111/j.1365-3156.2010.02533.x Vajdic, C. M., van Leeuwen, M. T., Webster, A. C., McCredie, M. R. E., Stewart, J. H., Chapman, J. R., Amin, J., McDonald, S. P., & Grulich, A. E. (2009). Cutaneous melanoma is related to immune suppression in kidney transplant recipients. Cancer Epidemiology, Biomarkers and Prevention, 18(8), 2297-2303. doi: 10.1158/1055-9965.EPI-09-0278 van Dalen, C. J., Aldridge, R. E., Chan, T., Senthilmohan, R., Hancox, R. J., Cowan, J. O., Taylor, D. R., Town, G. I., & Kettle, A. J. (2009). Bromotyrosines in sputum proteins and treatment effects of terbutaline and budesonide in asthma. Annals of Allergy Asthma & Immunology, 103(4), 348-353. van Leeuwen, M. T., Grulich, A. E., McDonald, S. P., McCredie, M. R. E., Amin, J., Stewart, J. H., et al. (2009). Immunosuppression and other risk factors for lip cancer after kidney transplantation. Cancer Epidemiology Biomarkers and Prevention, 18(2), 561-569. doi: 10.1158/1055-9965.EPI-08-0919 van Leeuwen, M. T., Webster, A. C., McCredie, M. R. E., Stewart, J. H., et al. (2010). Effect of reduced immunosuppression after kidney transplant failure on risk of cancer: Population based retrospective cohort study. British Medical Journal, 340Advance Online Publication, c570. doi: 10.1136/bmj.c570 van Roode, T., Dickson, N., Herbison, P., & Paul, C. (2009). Child sexual abuse and persistence of risky sexual behaviors and negative sexual outcomes over adulthood: Findings from a birth cohort. Child Abuse and Neglect, 33(3), 161-172. doi: 10.1016/j.chiabu.2008.09.006 Venn, B. J., Perry, T., Green, T. J., Skeaff, M., Aitken, W., Moore, N. J., Mann, J. I., Wallace, A. J., Monro, J., Bradshaw, A., Brown, R. C., Skidmore, P. M. L., Doel, K., O’Brien, K., Frampton, C., & Williams, S. (2010). The effect of increasing consumption of pulses and wholegrains in obese people: A randomized controlled trial. Journal of the American College of Nutrition, 29(4), 365-372. Venn, B. J., Williams, S. M., & Mann, J. I. (2010). Comparison of postprandial glycaemia in Asians and Caucasians. Diabetic Medicine, 27(10), 1205-1208. doi: 10.1111/j.1464-5491.2010.03069.x Waters, D. L., Baumgartner, R. N., Garry, P. J., & Vellas, B. (2010). Advantages of dietary, exercise-related, and therapeutic interventions to prevent and treat sarcopenia in adult patients: An update. Clinical Interventions in Aging, 5, 259-270. doi: 10.2147/CIA.S6920 Waters, D. L., Hale, L., Grant, A. M., Herbison, P., & Goulding, A. (2010). Osteoporosis and gait and balance disturbances in older sarcopenic obese New Zealanders. Osteoporosis International, 21(2), 351-357. doi: 10.1007/s00198-009-0947-5 Waters, D. L., Mullins, P. G., Qualls, C. R., Raj, D. S. C., Gasparovic, C., & Baumgartner, R. N. (2009). Mitochondrial function in physically active elders with sarcopenia. Mechanisms of Ageing and Development, 130(5), 315-319. doi: 10.1016/j. mad.2009.01.006 Welch, D., & Poulton, R. G. (2009). Personality influences on change in smoking behavior. Health Psychology, 28(3), 292-299. doi: 10.1037/a0013471 Wells, J. E., McGee, M. A., Baxter, J., Agnew, F., Kokaua, J., & New Zealand Mental Health Survey Research Team (2009). Onset and lifetime use of drugs in New Zealand: Results from Te Rau Hinengaro: The New Zealand Mental Health Survey 2003- 2004. Drug and Alcohol Review, 28(2), 166-174. doi: 10.1111/j.1465-3362.2008.00043.x Wilhelm, B., Rajić, A., Waddell, L., Parker, S., Harris, J., Roberts, K. C., Kydd, R. M., Greig, J., & Baynton, A. (2009). Prevalence of zoonotic or potentially zoonotic bacteria, antimicrobial resistance, and somatic cell counts in organic dairy production: Current knowledge and research gaps. Foodborne Pathogens and Disease, 6(5), 525-539. doi: 10.1089/fpd.2008.0181 Williamson, A., Lombardi, D. A., Folkard, S., Stutts, J., Courtney, T. K., & Connor, J. L. (2010). The link between fatigue and safety. Accident Analysis & Prevention, 43(2), 498-515. doi: 10.1016/j.aap.2009.11.011 Williams, S. M., & Goulding, A. (2009). Patterns of gowth associated with the timing of adiposity rebound. Obesity, 17(2), 335-341. doi: 10.1038/oby.2008.547 Wong, C-K., Leon de la Barra, S., & Herbison, P. (2010). Does ST resolution achieved via different reperfusion strategies (fibrinolysis vs percutaneous coronary intervention) have different prognostic meaning in ST-elevation myocardial infarction? A systematic review. American Heart Journal, 160(5), 842-848.e2. doi: 10.1016/j.ahj.2010.06.050

174 RESEARCH REPORT 2009/2010 Wong, C-K., Tang, E. W., & Herbison, P. (2009). Prognostic interactions between statins and in-hospital revascularisation on the outcome of acute coronary syndrome. Heart, Lung & Circulation, 18(4), 262-265. doi: 10.1016/j.hlc.2008.12.001 Wong, C-K., Tang, E. W., & Herbison, P. (2009). The use of different evidence-based medications and 5-year survival after an acute coronary syndrome: An observational study. International Journal of Cardiology, 132(2), 197-202. doi: 10.1016/j. ijcard.2007.11.005 Wong, S. H., Gochhait, S., Malhotra, D., ..., Hill, P. C., et al. (2010). Leprosy and the adaptation of human Toll-Like Receptor 1. PLoS Pathogens, 6(7), e1000979. doi: 10.1371/journal.ppat.1000979 Wright, A. A., Cook, C. E., Baxter, G. D., Garcia, J., & Abbott, J. H. (2010). Relationship between the Western Ontario and McMaster Universities Osteoarthritis Index physical function subscale and physical performance measures in patients with hip osteoarthritis. Archives of Physical Medicine and Rehabilitation, 91(10), 1558-1564. doi: 10.1016/j.apmr.2010.07.016

Journal - Research Other Armstrong, D., & Schep, L. (2009). Comparing bromism with methyl bromide toxicity [Letter to the editor]. Clinical Toxicology, 47(4), 371-372. doi: 10.1080/15563650902802544 Connor, J. (2010). [Review of the book The Cartwright Papers: Essays on the cervical cancer inquiry 1987-88]. New Zealand Medical Journal, 123(1319). Retrieved from http://www.nzma.org.nz/journal/123-1319/4242/content.pdf Cox, B., & Sneyd, M. J. (2009). PSA testing in asymptomatic men to diagnose prostate cancer remains experimental [Editorial]. New Zealand Medical Journal, 122(1296). Retrieved from http://www.nzma.org.nz/journal/122-1296/3640/ Grenier, D., Ugnat, A-M., McCourt, C., Scott, J., Laffin Thibodeau, M., Davis, M. A., & Dickson, N. P. (2009). Can active surveillance provide a rapid response to an emerging child health issue? The melamine example. Paediatrics and Child Health, 14(5), 285-286. Grisham, J. R., Moffitt, T. E., & Poulton, R. (2009). [Authors’ reply to the letter to the editor Childhood neuropsychological deficits and adult OCD]. British Journal of Psychiatry, 195(6), 555. doi: 10.1192/bjp.195.6.555 Hancox, R. J., & Beasley, R. (2010). Programming in asthma: The dice are loaded but not cast [Editorial]. Clinical and Experimental Allergy, 40(12), 1717-1718. doi: 10.1111/j.1365-2222.2010.03632.x Hancox, R. J., Mandhane, P. J., & Sears, M. R. (2010). [Reply to Letter to the editor]. Journal of Allergy and Clinical Immunology, 125(3), 765. doi: 10.1016/j.jaci.2009.11.011 Harrison-Woolrych, M. (2009). Safety data from New Zealand [Letter]. BMJ, 339, b5654. Herbison, P. (2009). Predicting who will benefit from treatment. Neurourology and Urodynamics, 28(3), 168-169. doi: 10.1002/ nau.20656 Lilley, R., Feyer, A-M., Firth, H., Cunningham, C., & Paul, C. (2010). Surveillance of working conditions and the work environment: Development of a national hazard surveillance tool in New Zealand. International Journal of Public Health, 55, 49-57. doi: 10.1007/s00038-009-0059-1 Lovell, S. (2009). [Review of the book Participatory action research approaches and methods: Connecting people, participation and place]. New Zealand Geographer, 65(2), 162-163. doi: 10.1111/j.1745-7939.2009.01158_4.x McCredie, M. (2010). A response to Professor Bryder’s comments on ‘Consequences in women of participating in a study of the natural history of cervical intraepithelial neoplasia 3’ [Letter]. New Zealand Medical Journal, 123(1320). Retrieved from http://www.nzma.org.nz/journal/archive.php O’Shea, C., Quick, A., Johnson, G., Carman, A., & Herbison, P. (2010). The effect of a Clark twin block on mandibular motion: A case report. Australian Orthodontic Journal, 26(2), 189-194. Paul, C. (2010). [Review of the book Disclosure dilemmas: Ethics of genetic prognosis after the ‘right to know/not to know’ debate]. Australian and New Zealand Journal of Public Health, 34(5), 534-U535. doi: 10.1111/j.1753-6405.2010.00606.x Priest, P. C. (2009). Causal interpretation requires appropriate study design. Diabetologia, 52(7), 1451. doi: 10.1007/s00125- 009-1346-3 Schep, L. J., Slaughter, R. J., Vale, J. A., & Beasley, D. M. G. (2009). A seaman with blindness and confusion [Case report]. BMJ, 339, b3929. doi: 10.1136/bmj.b3929. Vukotich, Jr, C. J., Coulborn, R. M., Aragon, T. J., Baker, M. G., ..., Priest, P., et al. (2010). Findings, gaps, and future direction for research in nonpharmaceutical interventions for pandemic influenza [Conference Summary]. Emerging Infectious Diseases, 16(4). doi: 10.3201/eid1604.090719 Williams, S. M., & Goulding, A. (2009). Early adiposity rebound is an important predictor of later obesity [Letter to the editor]. Obesity, 17(7), 1310. doi: 10.1038/oby.2009.104 Williams, S. M., Venn, B. J., & Green, T. J. (2010). Another approach to estimating the reliability of the glycaemic index: A different interpretation: Response by Williams et al [Letter to the editor]. British Journal of Nutrition, 103, 1697. doi: 10.1017/S0007114510000632

Journal - Professional & Other Non-Research Articles Al-Shaqsi, S., & Stringer, M. D. (2010). Focused assessment sonography for trauma: A fast overview of FAST: An ultrasound technique to assess patients with trauma. Student BMJ, 18, c1540. doi: 10.1136/sbmj.c1540 Gauld, R. (2010). Challenges lie in implementation. Asia Pacific Journal of Health Management, 5(2), 12-13. Hancox, R. J., Mandhane, P. J., & Sears, M. R. (2010). Cats and dogs: An attractive remedy versus atopy? Reply [Letter]. Journal of Allergy and Clinical Immunology, 125(3), 765. doi: 10.1016/j.jaci.2009.11.011

Division of HEALTH SCIENCES 175 McCredie, M. (2010). A response to Ms Sandercock and Dr Burls regarding the methods used in the analysis for our first paper ‘Natural history of cervical neoplasia and risk of invasive cancer in women diagnosed with cervical intraepithelial neoplasia 3’ [Letter]. New Zealand Medical Journal, 123(1321). Retrieved from http://www.nzmj.org/ journal/123-1321/4327/content.pdf McCredie, M., & Jones, R. W. (2010). Response to Elizabeth Overton’s comments about Ron Jones’ research [Letter]. New Zealand Medical Journal, 123(1327). Retrieved from http://www.nzma.org.nz/journal/123-1327/4489/content.pdf Paul, C. (2010). A response to Dr Paul Patten [Letter]. New Zealand Medical Journal, 123(1321). Retrieved from http://www. nzmj.org/journal/123-1321/4319/content.pdf Savage, R. L. (2010). Leflunomide in combination therapy for rheumatoid arthritis [Editorial]. Drug Safety, 33(6), 523-526. doi: 10.2165/11532390-000000000-00000

Commissioned Report for External Body Barusch, A., Waters, D., & Stirling, B. (2009). Enliven service evaluation initial report. Commissioned by Presbyterian Support Otago. Dunedin, New Zealand: University of Otago, 35p. Egan, R., & Amun, Q-t-a. (2009). Identifying priorities for psycho-social-spiritual cancer research in New Zealand: Perspectives from the Cancer Society of New Zealand Support Services [Scoping paper]. Commissioned by Cancer Society of New Zealand and the Cancer Society Social & Behavioural Research Unit. Dunedin, New Zealand: CSNZ Social & Behavioural Research Unit, University of Otago, 44p.

Working Paper; Discussion Paper; Technical Report Advisory Group on Conduct Problems, Blissett, W., Church, J., Fergusson, D., ..., Poulton, R., et al. (2009). Conduct problems: Best practice report. Wellington, New Zealand: Ministry of Social Development. (pp. 1-66). Cryer, C., Lovelock, K., Lilley, R., Davidson, P., Davie, G., Samaranayaka, A., McBride, D., Milosavljevic, S., & Morgaine, K. (2009). Effective occupational health interventions in agriculture: Report of a survey of risk factors and exposures on farms [IPRU Report No. ORO76]. Dunedin, New Zealand: Injury Prevention Research Unit, Department of Preventive and Social Medicine, University of Otago. (pp. 1-169). Egan, R., McKechnie, R., Jopson, J., Herbison, P., & Richards, R. (2010). Factors influencing referrals to cancer support services in New Zealand. Dunedin, New Zealand: CSNZ Social & Behavioural Research Unit, University of Otago. (pp. 1-74). Harrison-Woolrych, M., Malik, M., Herbison, P., Holt, A., & Jamieson, S. (2009). Electronic capture of medicines exposure data for improved product vigilance in New Zealand: IMMP feasibility study: April 2008-March 2009. Dunedin, New Zealand: University of Otago. (pp. 1-70). Horsburgh, S., Malik, M., Norris, P., Harrison-Woolrych, M., Tordoff, J., Becket, G., Herbison, P., Parkin, L., & Reith, D. (2009). Prescribing and dispensing data sources in New Zealand: Their usage and future directions [Technical Report No. 001/09]. Dunedin, New Zealand: School of Pharmacy, University of Otago. (pp. 1-63). Lilley, R., Cryer, C., Lovelock, K., Davidson, P., McBride, D., Milosavljevic, S., & Morgaine, K. (2009). Effective occupational health interventions in agriculture: An international literature review of primary interventions designed to reduce injury and disease in agriculture [IPRU Report No. ORO75]. Dunedin, New Zealand: Injury Prevention Research Unit, Department of Preventive and Social Medicine, University of Otago. (pp. 1-68).

Awarded PhD Thesis Quigg, R. (2010). Assessing the effect of up-grading playgrounds on children’s physical activity. Dunedin, New Zealand: University of Otago, 155p.

IPRU, Preventive & Social Medicine

Chapter in Book - Research Connor, J. L. (2009). The role of driver sleepiness in car crashes: A review of the epidemiological evidence. In J. C. Verster, S. R. Pandi-Perumal, J. G. Ramaekers, & J. J. de Gier (Eds.), Drugs, Driving and Traffic Safety (pp. 187-205). Basel, Switzerland: Berkhäuser.

Journal - Research Article Ameratunga, S., Tin, S. T., Connor, J., & Norton, R. (2010). Chronic neck pain following car crashes: A population-based study from Auckland, New Zealand. Internal Medicine Journal, 40(10), 704-709. doi: 10.1111/j.1445-5994.2009.02101.x Ameratunga, S., Tin Tin, S. T., Coverdale, J., Connor, J., & Norton, R. (2009). Posttraumatic stress among hospitalized and nonhospitalized survivors of serious car crashes: A population-based study. Psychiatric Services, 60(3), 402-404. doi: 10.1176/appi.ps.60.3.402 Begg, D., & Langley, J. (2009). A critical examination of the arguments against raising the car driver licensing age in New Zealand. Traffic Injury Prevention, 10(1), 1-8. Begg, D., Langley, J., Brookland, R., McDowell, A., Ameratunga, S., & Broughton, J. (2009). The opinions of newly licensed drivers in New Zealand on the minimum car driver licensing age and reasons for getting a licence. New Zealand Medical Journal, 122(1306). Retrieved from http://www.nzma.org.nz/journal/122-1306/3880/

176 RESEARCH REPORT 2009/2010 Begg, D., Langley, J., Broughton, J., Brookland, R., Ameratunga, S., & McDowell, A. (2009). New Zealand drivers study: A follow-up study of newly licensed drivers. Injury Prevention, 15(4), e2. doi: 10.1136/ip.2009.021998 Brookland, R., Begg, D., Langley, J., & Ameratunga, S. (2009). Parent and adolescent risky driving behaviours: New Zealand Drivers Study. Journal of the Australasian College of Road Safety, 20(1), 52-59. Connor, J., & Casswell, S. (2009). The burden of road trauma due to other people’s drinking. Accident Analysis and Prevention, 41, 1099-1103. doi: 10.1016/j.aap.2009.06.019 Connor, J., Gray, A., & Kypri, K. (2010). Drinking history, current drinking and problematic sexual experiences among university students. Australian and New Zealand Journal of Public Health, 34(5), 487-494. doi: 10.1111/j.1753- 6405.2010.00595.x Connor, J. L., Kypri, K., Bell, M. L., & Cousins, K. (2010). Alcohol outlet density, levels of drinking and alcohol-related harm in New Zealand: A national study. Journal of Epidemiology and Community Health, Advance Online Publication. doi: 10.1136/ jech.2009.104935 Cousins, K., Connor, J. L., & Kypri, K. (2010). Reducing alcohol-related harm and social disorder in a university community: A framework for evaluation. Injury Prevention, 16(5), e1-e6. doi: 10.1136/ip.2010.027961 Cryer, C., Gulliver, P., Langley, J. D., & Davie, G. (2010). Is length of stay in hospital a stable proxy for injury severity? Injury Prevention, 116, 254-260. doi: 10.1136/ip.2009.023903 Davidson, P. L., Wilson, S. J., Chalmers, D. J., Wilson, B. D., & McBride, D. (2009). Examination of interventions to prevent common lower-limb injuries in the New Zealand Defense Force. Military Medicine, 174(11), 1196-1202. Davidson, P. L., Wilson, S. J., Wilson, B. D., & Chalmers, D. J. (2009). An approach to modeling impact energy absorption by surfaces. Journal of Applied Biomechanics, 25(4), 351-359. Davidson, P. L., Wilson, S. J., Wilson, B. D., & Chalmers, D. J. (2009). Energy analysis of wrist impact and surface rebound. Computer Methods in Biomechanics and Biomedical Engineering, Advance Online Publication. doi: 10.1080/10255840903337863 Day, L., Voaklander, D., Sim, M., Wolfe, R., Langley, J., Dosman, J., Hagel, L., & Ozanne-Smith, J. (2009). Risk factors for work related injury among male farmers. Occupational and Environmental Medicine, 66(5), 312-318. doi: 10.1136/ oem.2008.040808 Derrett, S., Bevin, T. H., Herbison, P., & Paul, C. (2009). Access to elective surgery in New Zealand: Considering equity and the private and public mix. International Journal of Health Planning and Management, 24(2), 147-160. doi: 10.1002/hpm.978 Derrett, S., Black, J., & Herbison, G. P. (2009). Outcome after injury: A systematic literature search of studies using the EQ-5D. Journal of Trauma, 67(4), 883-890. doi: 10.1097/TA.0b013e3181ae6409 Derrett, S., Darmody, M., Williams, S., Rutherford, M., Schollum, J., & Walker, R. (2010). Older peoples’ satisfaction with home-based dialysis. Nephrology, 15(4), 464-470. doi: 10.1111/j.1440-1797.2010.01286.x Derrett, S., Davie, G., Ameratunga, S., & Langley, J. (2010). Capturing outcomes following injury: A New Zealand pilot study. New Zealand Medical Journal, 123(1316). Retrieved from http://www.nzma.org.nz/journal/archive.shtml Derrett, S., Langley, J., Hokowhitu, B., Ameratunga, S., Hansen, P., Davie, G., Wyeth, E., & Lilley, R. (2009). Prospective outcomes of injury study. Injury Prevention, 15(5), e3. doi: 10.1136/ip.2009.022558 Derrett, S., Walley, G. D., Bridgman, S. A., Richards, P., & Maffulli, N. (2009). Magnetic resonance imaging, knee arthroscopy, and clinical decision making: A descriptive study of five surgeons. International Journal of Technology Assessment in Health Care, 25(4), 577-583. doi: 10.1017/S0266462309990419 Fuamatu, N., Simpson, J., Allan-Moetaua, A., & Southwick, M. (2009). The Pacific advisory group: Reflections on its utility in health research. Pacific Health Dialog, 15(2), 107-115. Gulliver, P., Chalmers, D., & Cousins, K. (2009). Achieving compliance with pool fencing legislation in New Zealand: How much progress has been made in 10 years? International Journal of Injury Control and Safety Promotion, 16(3), 127-132. doi: 10.1080/17457300903024004 Gulliver, P., Cryer, C., Davie, G., & Langley, J. (2010). An investigation into methods to develop indicators to measure injury related impairment. Injury Prevention, 16(4), 240-246. doi: 10.1136/ip.2009.022913 Hallett, J., Maycock, B., Kypri, K., Howat, P., & McManus, A. (2009). Development of a web-based alcohol intervention for university students: Processes and challenges. Drug and Alcohol Review, 28(1), 31-39. doi: 10.1111/j.1465- 3362.2008.00008.x Han, S. Y., Wilson, S. J., & Bolter, C. P. (2010). Tertiapin-Q removes a mechanosensitive component of muscarinic control of the sinoatrial pacemaker in the rat. Clinical and Experimental Pharmacology and Physiology, 37, 900-904. doi: 10.1111/j.1440-1681.2010.05408.x Harcombe, H., McBride, D., Derrett, S., & Gray, A. (2009). Prevalence and impact of musculoskeletal disorders in New Zealand nurses, postal workers and office workers. Australian and New Zealand Journal of Public Health, 33(5), 437-441. doi: 10.1111/j.1753-6405.2009.00425.x Harcombe, H., McBride, D., Derrett, S., & Gray, A. (2010). Physical and psychosocial risk factors for musculoskeletal disorders in New Zealand nurses, postal workers and office workers. Injury Prevention, 16(2), 96-100. doi: 10.1136/ip.2009.021766 Hay, G. C., Whigham, P. A., Kypri, K., & Langley, J. D. (2009). Neighbourhood deprivation and access to alcohol outlets: A national study. Health & Place, 15(4), 1086-1093. doi: 10.1016/j.healthplace.2009.05.008 Hay, G., Kypri, K., Whigham, P., & Langley, J. (2009). Potential biases due to geocoding error in spatial analyses of official data. Health and Place, 15(2), 562-567. doi: 10.1016/j.healthplace.2008.09.002 Hosking, J., Macmillan, A., Connor, J., Bullen, C., & Ameratunga, S. (2010). Organisational travel plans for improving health. Cochrane Database of Systematic Reviews, (3), CD005575. doi: 10.1002/14651858.CD005575.pub3

Division of HEALTH SCIENCES 177 Kypri, K., Davie, G., Langley, J., Voas, R., & Begg, D. (2009). The utility of routinely collected data in evaluating important policy changes: The New Zealand alcohol purchasing age limit example. American Journal of Public Health, 99(7), 1212- 1215. doi: 10.2105/ajph.2007.120212 Kypri, K., Hallett, J., Howat, P., McManus, A., Maycock, B., Bowe, S., & Horton, N. J. (2009). Randomized controlled trial of proactive web-based alcohol screening and brief intervention for university students. Archives of Internal Medicine, 169(16), 1508-1514. Kypri, K., McCambridge, J., Cunningham, J. A., Vater, T., Bowe, S., De Graaf, B., Saunders, J. B., & Dean, J. (2010). Web-based alcohol screening and brief intervention for Mäaori and non-Mäori: The New Zealand e-SBINZ trials. BMC Public Health, 10, 781. doi: 10.1186/1471-2458-10-781 Kypri, K., Paschall, M. J., Langley, J., Baxter, J., Cashell-Smith, M., & Bourdeau, B. (2009). Drinking and alcohol-related harm among New Zealand university students: Findings from a national web-based survey. Alcoholism: Clinical and Experimental Research, 33(2), 307-314. doi: 10.1111/j.1530-0277.2008.00834.x Kypri, K., Paschall, M. J., Langley, J. D., Baxter, J., & Bourdeau, B. (2010). The role of drinking locations in university student drinking: Findings from a national web-based survey. Drug and Alcohol Dependence, 111, 38-43. doi: 10.1016/j. drugalcdep.2010.03.018 Langley, J., Samaranayaka, A., Davie, G., & Campbell, A. J. (2010). Age, cohort and period effects on hip fracture incidence: Analysis and predictions from New Zealand data 1974-2007. Osteoporosis International, Advance Online Publication. doi: 10.1007/s00198-010-1205-6 Marsh, L., McGee, R., Nada-Raja, S., & Williams, S. (2010). Text bullying and traditional bullying among New Zealand secondary school students. Journal of Adolescence, 33(1), 237-240. doi: 10.1016/j.adolescence.2009.06.001 McClure, C. K., Katz, K. D., Patrick, T. E., Kelsey, S. F., & Weiss, H. B. (2010). The epidemiology of acute poisonings in women of reproductive age and during pregnancy, California, 2000-2004. Maternal and Child Health Journal, Advance Online Publication. doi: 10.1007/s10995-010-0571-1 McDonald, G., Davie, G., & Langley, J. (2009). Validity of police-reported information on injury severity for those hospitalized from motor vehicle traffic crashes. Traffic Injury Prevention, 10(2), 184-190. doi: 10.1080/15389580802593699 McDowell, A., Begg, D., Connor, J., & Broughton, J. (2009). Unlicensed driving among urban and rural Mäori drivers: New Zealand drivers study. Traffic Injury Prevention, 10(6), 538-545. doi: 10.1080/15389580903321727 McGee, R., Williams, S., & Kypri, K. (2010). College students’ readiness to reduce binge drinking: Criterion validity of a brief measure. Drug and Alcohol Dependence, 109, 236-238. doi: 10.1016/j.drugalcdep.2009.12.009 McIntosh, A. S., McCrory, P., Finch, C. F., Best, J. P., Chalmers, D. J., & Wolfe, R. (2009). Does padded headgear prevent head injury in rugby union football? Medicine and Science in Sports and Exercise, 41(2), 306-313. doi: 10.1249/ MSS.0b013e3181864bee McLean, R., & Connor, J. (2009). Alcohol and injury: A survey in primary care settings. New Zealand Medical Journal, 122(1303). Retrieved from http://www.nzma.org.nz/journal/122-1303/3798/ McNoe, B. M., & Chalmers, D. J. (2010). Injury in community-level soccer: Development of an injury surveillance system. American Journal of Sports Medicine, 38(12), 2542-2551. doi: 10.1177/0363546510377415 Miller, T. R., Teti, L. O., Lawrence, B. A., & Weiss, H. B. (2010). Alcohol involvement in hospital-admitted nonfatal suicide acts. Suicide and Life-Threatening Behavior, 40(5), 492-499. doi: 10.1521/suli.2010.40.5.492 Paschall, M. J., Grube, J. W., & Kypri, K. (2009). Alcohol control policies and alcohol consumption by youth: A multi-national study. Addiction, 104(11), 1849-1855. doi: 10.1111/j.1360-0443.2009.02698.x Russell, M., Buckley, S., Walton, C., Gerring, Z., & Black, J. (2009). Abusive and inappropriate sexual behaviour among Years 7 and 8 students: A survey of teachers. set: Research Information for Teachers, 1, 5-11. Samaranayaka, A., & Fletcher, D. (2010). Modelling environmental stochasticity in adult survival for a long-lived species. Ecological Modelling, 221(3), 423-427. doi: 10.1016/j.ecolmodel.2009.10.016 Sauber-Schatz, E. K., Markovic, N., Weiss, H. B., Bodnar, L. M., Wilson, J. W., & Pearlman, M. D. (2010). Descriptive epidemiology of birth trauma in the United States in 2003. Paediatric and Perinatal Epidemiology, 24, 116-124. doi: 10.1111/j.1365-3016.2009.01077.x Sellman, D., & Connor, J. (2009). In utero brain damage from alcohol: A preventable tragedy. New Zealand Medical Journal, 122(1306). Retrieved from http://www.nzma.org.nz/journal/122-1306/3888/ Simpson, J. C., Turnbull, B. L., Ardagh, M., & Richardson, S. (2009). Child home injury prevention: Understanding the context of unintentional injuries to preschool children. International Journal of Injury Control and Safety Promotion, 16(3), 159- 167. doi: 10.1080/17457300903135636 Skegg, K., Nada-Raja, S., Dickson, N., & Paul, C. (2010). Perceived ²out of control² sexual behavior in a cohort of young adults from the Dunedin Multidisciplinary Health and Development Study. Archives of Sexual Behavior, 39, 968-978. doi: 10.1007/s10508-009-9504-8 Smartt, P., & Chalmers, D. (2009). A new look at horse-related sport and recreational injury in New Zealand. Journal of Science and Medicine in Sport, 12(3), 376-382. doi: 10.1016/j.jsams.2008.04.001 Smartt, P., & Chalmers, D. (2009). Obstructing the goal? Hospitalisation for netball injury in New Zealand 2000-2005. New Zealand Medical Journal, 122(1288). Retrieved from http://www.nzma.org.nz/journal/122-1288/3438/ Smartt, P., & Chalmers, D. (2010). Searching for ski-lift injury: An uphill struggle? Journal of Science and Medicine in Sport, 13(2), 205-209. doi: 10.1016/j.jsams.2009.01.004 Sullivan, M., Paul, C. E., Herbison, G. P., Tamou, P., Derrett, S., & Crawford, M. (2010). A longitudinal study of the life histories of people with spinal cord injury. Injury Prevention, 16(6). doi: 10.1136/ip.2010.028134

178 RESEARCH REPORT 2009/2010 Tin Tin, S., Woodward, A., Thornley, S., Langley, J., Rodgers, A., & Ameratunga, S. (2010). Cyclists’ attitudes toward policies encouraging bicycle travel: Findings from the Taupo bicycle study in New Zealand. Health Promotion International, 25(1), 54-62. doi: 10.1093/heapro/dap041 Walker, H. L., Carr, D. J., Chalmers, D. J., & Wilson, C. A. (2010). Injury to recreational and professional cricket players: Circumstances, type and potential for intervention. Accident Analysis & Prevention, 42(6), 2094-2098. doi: 10.1016/j. aap.2010.06.022 Wyeth, E. H., Derrett, S., Hokowhitu, B., Hall, C., & Langley, J. (2010). Rangatiratanga and Ōritetanga: Responses to the Treaty of Waitangi in a New Zealand study. Ethnicity and Health, 15(3), 303-316. doi: 10.1080/13557851003721194

Journal - Research Other Cryer, C., & Davie, G. (2010). Alcohol, ethnicity and service use in trauma patients: Challenges of presenting and interpreting effect modification [Editorial]. Injury, Advance Online Publication. doi: 10.1016/j.injury.2010.11.033 Howat, P., Hallett, J., Kypri, K., Maycock, B., Dhaliwal, S., & McManus, A. (2010). Tobacco smoking in an Australian university sample and implications for health promotion [Letter to the editor]. Preventive Medicine, Advance Online Publication. doi: 10.1016/j.ypmed.2010.08.015 Kypri, K., Langley, J. D., & Connor, J. (2010). ALCOHOL IN OUR LIVES: A once-in-a generation opportunity for liquor law reform in New Zealand [Editorial]. Drug and Alcohol Review, 29(1), 1-4. doi: 10.1111/j.1465-3362.2009.00139.x Langley, J. (2010). New Zealand Injury Prevention Strategy: Significant shortcomings after 5 years [Viewpoint]. New Zealand Medical Journal, 123(1327). Retrieved from http://www.nzma.org.nz/journal/123-1327/4466/content.pdf Langley, J., & Simpson, J. (2009). Injury surveillance: Unrealistic expectations of safe communities [Commentary]. Injury Prevention, 15(3), 146-149. doi: 10.1136/ip.2008.020974 Lilley, R., Feyer, A-M., Firth, H., Cunningham, C., & Paul, C. (2010). Surveillance of working conditions and the work environment: Development of a national hazard surveillance tool in New Zealand. International Journal of Public Health, 55, 49-57. doi: 10.1007/s00038-009-0059-1 McCall, J., & Connor, J. (2010). Systematic reviews in public health research [Editorial]. Australian and New Zealand Journal of Public Health, 34(4), 343-344. doi: 10.1111/j.1753-6405.2009.00562.x Sellman, D., Connor, J., Robinson, G., & Jackson, R. (2009). Alcohol cardio-protection has been talked up. New Zealand Medical Journal, 122(1303). Retrieved from http://www.nzma.org.nz/journal/archive.shtml Sellman, J. D., Connor, J. L., & Joyce, P. R. (2010). How to reduce alcohol-related problems in adolescents: What can parents do and what can the government do? [Editorial]. Australian and New Zealand Journal of Psychiatry, 44(9), 771-773. doi: 10.3109/00048674.2010.516425

Journal - Professional & Other Non-Research Articles Weiss, H., & Begg, D. (2010). Driving more slowly definitely saves lives. Otago Daily Times. Retrieved from http://www.odt. co.nz/

Commissioned Report for External Body Butler, M. (2010). A care ethic for informal carers [Supporting document for the report ‘How should we care for the carers, now and into the future? Manaaki tangata’]. Commissioned by National Health Committee. Wellington, New Zealand: NHC, 22p. Retrieved from http://www.nhc.health.govt.nz/moh.nsf/indexcm/nhc-how-should-we-care-for-the-carers Gulliver, P., Cryer, C., & Davie, G. (2010). A chartbook of the injury related impairment indicators 2001-2008 [Injury Prevention Research Unit, University of Otago: OR084]. Commissioned by New Zealand Injury Prevention Strategy Secretariat, ACC. Wellington, New Zealand: Accident Compensation Corporation, 33p. Gulliver, P., Cryer, C., & Davie, G. (2010). A chartbook of the New Zealand Injury Prevention Strategy serious injury outcome indicators for children: 1994-2008 [Injury Prevention Research Unit, University of Otago: OR082]. Commissioned by New Zealand Injury Prevention Strategy Secretariat, ACC. Wellington, New Zealand: Accident Compensation Corporation, 32p. Gulliver, P., Cryer, C., & Davie, G. (2010). A chartbook of the New Zealand Injury Prevention Strategy serious injury outcome indicators: 1994-2008 [Injury Prevention Research Unit, University of Otago: OR081]. Commissioned by New Zealand Injury Prevention Strategy Secretariat, ACC. Wellington, New Zealand: Accident Compensation Corporation, 53p. Gulliver, P., Cryer, C., & Davie, G. (2010). A chartbook of the New Zealand Injury Prevention Strategy serious injury outcome indicators for Mäori: 1996-2008 [Injury Prevention Research Unit, University of Otago: OR080]. Commissioned by New Zealand Injury Prevention Strategy Secretariat, ACC. Wellington, New Zealand: Accident Compensation Corporation, 36p.

Working Paper; Discussion Paper; Technical Report Cryer, C., Gulliver, P., Samaranayaka, A., Davie, G., Langley, J., & Fowler, C. (2010). New Zealand Injury Prevention Strategy indicators of injury death: Are we counting all the cases? [IPRU Report No. OR085]. Dunedin, New Zealand: Injury Prevention Research Unit, Department of Preventive and Social Medicine, University of Otago. (pp. 1-107). Cryer, C., Lovelock, K., Lilley, R., Davidson, P., Davie, G., Samaranayaka, A., McBride, D., Milosavljevic, S., & Morgaine, K. (2009). Effective occupational health interventions in agriculture: Report of a survey of risk factors and exposures on farms [IPRU Report No. ORO76]. Dunedin, New Zealand: Injury Prevention Research Unit, Department of Preventive and Social Medicine, University of Otago. (pp. 1-169). Gulliver, P., Cryer, C., & Davie, G. (2009). Investigation of provisional status of the NZIPS serious non-fatal self-harm and assault indicators [IPRU Report No. OR083]. Dunedin, New Zealand: Injury Prevention Research Unit, Department of Preventive and Social Medicine, University of Otago. (pp. 1-41).

Division of HEALTH SCIENCES 179 Lilley, R., Cryer, C., Lovelock, K., Davidson, P., McBride, D., Milosavljevic, S., & Morgaine, K. (2009). Effective occupational health interventions in agriculture: An international literature review of primary interventions designed to reduce injury and disease in agriculture [IPRU Report No. ORO75]. Dunedin, New Zealand: Injury Prevention Research Unit, Department of Preventive and Social Medicine, University of Otago. (pp. 1-68). Lovelock, K., & Cryer, C. (2009). Effective occupational health interventions in agriculture: Summary report [IPRU Report No. ORO72]. Dunedin, New Zealand: Injury Prevention Research Unit, Department of Preventive and Social Medicine, University of Otago. (pp. 1-31).

Dunedin School of Medicne Department of Psychological Medicine

Journal - Research Article Alemayehu, D., Andrews, E. N., Glue, P., & Knirsch, C. A. (2010). Considerations for the design and conduct of a pharmacovigilance study involving mass drug administration in a resource-constrained setting. PLoS, 4(1), e564. doi: 10.1371/journal.pntd.0000564 Andrews, E., Glue, P., Fang, J., Crownover, P., Tressler, R., & Damle, B. (2010). Assessment of the pharmacokinetics of co- administered maraviroc and raltegravir. British Journal of Clinical Pharmacology, 69(1), 51-57. doi: 10.1111/j.1365- 2125.2009.03546.x Cape, G. (2009). Movies as a vehicle to teach addiction medicine. International Review of Psychiatry, 21(3), 213-217. doi: 10.1080/09540260902747094 Citrome, L., Yang, R., Glue, P., & Karayal, O. N. (2009). Effect of ziprasidone dose on all-cause discontinuation rates in acute schizophrenia and schizoaffective disorder: A post-hoc analysis of 4 fixed-dose randomized clinical trials. Schizophrenia Research, 111(1-3), 39-45. Damle, B. D., Uderman, H., Biswas, P., Crownover, P., Lin, C., & Glue, P. (2009). Influence of CYP2C19 polymorphism on the pharmacokinetics of nelfinavir and its active metabolite. British Journal of Clinical Pharmacology, 68(5), 682-689. doi: 10.1111/j.1365-2125.2009.03499.x Damle, B., Fosser, C., Ito, K., Tran, A., Clax, P., Uderman, H., & Glue, P. (2009). Effects of standard and supratherapeutic doses of nelfinavir on cardiac repolarization: A thorough QT study. Journal of Clinical Pharmacology, 49(3), 291-300. doi: 10.1177/0091270008329551 Gale, C., Arroll, B., & Coverdale, J. (2009). The 12-month prevalence of patient-initiated aggression against psychiatrists: A New Zealand national Survey. International Journal of Psychiatry in Medicine, 39(1), 79-87. doi: 10.2190/PM.39.1.f Gale, C., Hannah, A., Swain, N., Gray, A., Coverdale, J., & Oud, N. (2009). Patient aggression perceived by community support workers. Australasian Psychiatry, 17(6), 497-501. doi: 10.1080/10398560903287516 Gandelman, K., Alderman, J. A., Glue, P., Lombardo, I., LaBadie, R. R., Versavel, M., & Preskorn, S. H. (2009). The impact of calories and fat content of meals on oral ziprasidone absorption: A randomized, open-label, crossover trial. Journal of Clinical Psychiatry, 70(1), 58-62. Glue, P., Donovan, M. R., Kolluri, S., & Emir, B. (2010). Meta-analysis of relapse prevention antidepressant trials in depressive disorders. Australian and New Zealand Journal of Psychiatry, 44(8), 697-705. doi: 10.3109/00048671003705441 Glue, P., & Patterson, T. (2009). Can drug treatments enhance learning in subjects with intellectual disability? Australian and New Zealand Journal of Psychiatry, 43(10), 899-904. doi: 10.1080/00048670903179178 Lee, S., Malhotra, B., Creanga, D., Carlsson, M., & Glue, P. (2009). A meta-analysis of the placebo response in antimuscarinic drug trials for overactive bladder. BMC Medical Research Methodology, 9. doi: 10.1186/1471-2288-9-55 Malhotra, B. K., Crownover, P. H., LaBadie, R., Glue, P., & MacDiarmid, S. A. (2010). The pharmacokinetic profile of fesoterodine 8 mg with daytime or nighttime dosing. European Journal of Clinical Pharmacology, 66(2), 171-176. doi: 10.1007/s00228-009-0748-y Miller, J., Shepherdson, P., & Trevena, J. (2010). Effects of clock monitoring on electroencephalographic activity: Is unconscious movement initiation an artifact of the clock? Psychological Science, Advance Online Publication. doi: 10.1177/0956797610391100 Mullen, R., & Linscott, R. J. (2010). A comparison of delusions and overvalued ideas. Journal of Nervous and Mental Disease, 198(1), 35-38. doi: 10.1097/NMD.0b013e3181c818b2 Patterson, T., & Pipe, M-E. (2009). Exploratory assessments of child abuse: Children’s responses to interviewer’s questions across multiple interview sessions. Child Abuse and Neglect, 33(8), 490-504. doi: 10.1016/j.chiabu.2008.12.012 Simpson, D. M., Schifitto, G., Clifford, D. B., Murphy, T. K., Durso-De Cruz, E., Glue, P., ..., & 1066 HIV Neuropathy Study Group (2010). Pregabalin for painful HIV neuropathy: A randomized, double-blind, placebo-controlled trial. Neurology, 74(5), 413-420. doi: 10.1212/WNL.0b013e3181ccc6ef Skegg, K., Firth, H., Gray, A., & Cox, B. (2010). Suicide by occupation: Does access to means increase the risk? Australian and New Zealand Journal of Psychiatry, 44(5), 429-434. doi: 10.3109/00048670903487191 Skegg, K., & Herbison, P. (2009). Effect of restricting access to a suicide jumping site. Australian and New Zealand Journal of Psychiatry, 43(6), 498-502. Skegg, K., Nada-Raja, S., Dickson, N., & Paul, C. (2010). Perceived ²out of control² sexual behavior in a cohort of young adults from the Dunedin Multidisciplinary Health and Development Study. Archives of Sexual Behavior, 39, 968-978. doi: 10.1007/s10508-009-9504-8

180 RESEARCH REPORT 2009/2010 Swain-Campbell, N., & Quinlan, D. (2009). Children’s school, classroom, social well-being and health in New Zealand mid to low decile primary schools. New Zealand Journal of Education Studies, 44(2), 79-92. Sweeney, K. R., Gastonguay, M. R., Benincosa, L., Cronenberger, C. L., Glue, P., & Malhotra, B. K. (2010). Exposure-response modeling and clinical trial simulation of the effect of tolterodine on QT intervals in healthy volunteers. Drug Discoveries & Therapeutics, 4(1), 44-53. Tarr, G. P., Glue, P., & Herbison, P. (2010). Comparative efficacy and acceptability of mood stabilizer and second generation antipsychotic monotherapy for acute mania: A systematic review and meta-analysis. Journal of Affective Disorders, Advance Online Publication. doi: 10.1016/j.jad.2010.11.009 Trevena, J., & Miller, J. (2010). Brain preparation before a voluntary action: Evidence against unconscious movement initiation. Consciousness and Cognition, 19(1), 447-456. doi: 10.1016/j.concog.2009.08.006

Journal - Research Other Donovan, M. R., Glue, P., Kolluri, S., & Emir, B. (2010). Comparative efficacy of antidepressants in preventing relapse in anxiety disorders: A meta-analysis. Journal of Affective Disorders, 123(1-3), 9-16. doi: 10.1016/j.jad.2009.06.021

Dunedin School of Medicne Department of Women’s and Children’s Health Obstetrics & Gynaecology

Journal - Research Article Daniels, K., Gillett, W., & Grace, V. (2009). Parental information sharing with donor insemination conceived offspring: A follow-up study. Human Reproduction, 24(5), 1099-1105. doi: 10.1093/humrep/den495 Gillett, W. R., & Jones, D. (2009). Chronic pelvic pain in women: Role of the nervous system. Expert Review of Obstetrics & Gynecology, 4(2), 149-163. doi: 10.1586/17474108.4.2.149 Glazener, C., Wilson, D., MacArthur, C., Lancashire, R., & Herbison, P. (2009). Randomised controlled trial (RCT) of conservative management of postnatal urinary and faecal incontinence: Twelve year follow up. International Urogynecology Journal, 20(Suppl. 2), S79. doi: 10.1007/s00192-009-0896-8 Herbison, P., Hay-Smith, J., Paterson, H., Ellis, G., & Wilson, D. (2009). Research priorities in urinary incontinence: Results from citizens’ juries. BJOG, 116(5), 713-718. doi: 10.1111/j.1471-0528.2008.02093.x Leitch, S., & Dovey, S. (2010). Review of registration requirements for new part-time doctors in New Zealand, Australia, the United Kingdom, Ireland and Canada. Journal of Primary Health Care, 2(4), 273-280. Lim, K. H., Brooks, H., McDougal, R., Burton, J., Devenish, C., & De Silva, T. (2010). Is there a correlation between bacterial vaginosis and preterm labour in women in the Otago region of New Zealand? Australian and New Zealand Journal of Obstetrics and Gynaecology, 50(3), 226-229. doi: 10.1111/j.1479-828X.2010.01149.x Paterson, H., Ashton, J. A., & Harrison-Woolrych, M. (2009). A nationwide cohort study of the use of the levonorgestrel intrauterine device in New Zealand adolescents. Contraception, 79(6), 433-438. doi: 10.1016/j.contraception.2008.12.001 Paterson, H., Miller, D., & Devenish, C. (2009). A survey of New Zealand RANZCOG Fellows on their use of the levonorgestrel intrauterine device in adolescents. Australian and New Zealand Journal of Obstetrics and Gynaecology, 49(2), 220-225. doi: 10.1111/j.1479-828x.2009.00973.x Pechtor, K., Richards, B., & Paterson, H. (2010). Antenatal catastrophic uterine rupture at 32 weeks of gestation after previous B-Lynch suture. BJOG, 117(7), 889-891. doi: 10.1111/j.1471-0528.2010.02554.x

Paediatrics & Child Health

Journal - Research Article Aaltonen, K., Ragupathy, R., Tordoff, J., Reith, D., & Norris, P. (2010). The impact of pharmaceutical cost containment policies on the range of medicines available and subsidized in Finland and New Zealand. Value in Health, 13(1), 148-156. doi: 10.1111/j.1524-4733.2009.00598.x Anderson, S., Menten, B., von Kogelenberg, M., Robertson, S., Waginger, M., Mentzel, H-J., et al. (2009). Aicardi syndrome in a male patient. Neuropediatrics, 40(1), 39-42. doi: 10.1055/s-0029-1220760 Arai, A., Mitsuhashi, S., Saito, Y., Komaki, H., Sakuma, H., ..., Robertson, S. P., et al. (2009). Nemaline (actin) myopathy with myofibrillar dysgenesis and abnormal ossification. Neuromuscular Disorders, 19(7), 485-488. doi: 10.1016/j. nmd.2009.06.366 Askie, L. M., Baur, L. A., Campbell, K., ..., Taylor, B., Taylor, R., et al. (2010). The Early Prevention of Obesity in Children (EPOCH) Collaboration: An individual patient data prospective meta-analysis. BMC Public Health, 10, 728. doi: 10.1186/1471-2458-10-728 Bruno, D. L., Ganesamoorthy, D., Schoumans, J., Bankier, A., Coman, D., Delatycki, M., Gardner, R. J. M., et al. (2009). Detection of cryptic pathogenic copy number variations and constitutional loss of heterozygosity using high resolution SNP microarray analysis in 117 patients referred for cytogenetic analysis and impact on clinical practice. Journal of Medical Genetics, 46, 123-131. doi: 10.1136/jmg.2008.062604

Division of HEALTH SCIENCES 181 Clark, A. R., Sawyer, G. M., Robertson, S. P., & Sutherland-Smith, A. J. (2009). Skeletal dysplasias due to filamin A mutations result from a gain-of-function mechanism distinct from allelic neurological disorders. Human Molecular Genetics, 18(24), 4791-4800. doi: 10.1093/hmg/ddp442 Dale, K. S., McAuley, K. A., Taylor, R. W., Williams, S. M., Farmer, V. L., Hansen, P., Vorgers, S. M., Chisholm, A. W., & Mann, J. I. (2009). Determining optimal approaches for weight maintenance: A randomized controlled trial. CMAJ, 180(10), E39-E46. doi: 10.1503/cmaj.080974 Dickson, N., Kara, T., & Tuohy, P. G. (2009). Rapid national survey of renal stones in New Zealand infants. Journal of Paediatrics and Child Health, 45, 633-635. doi: 10.1111/j.1440-1754.2009.01585.x Fukuzawa, R., Holman, S. K., Chow, C. W., Savarirayan, R., Reeve, A. E., & Robertson, S. P. (2010). WTX mutations can occur both early and late in the pathogenesis of Wilms tumour. Journal of Medical Genetics, Advance Online Publication. doi: 10.1136/jmg.2010.080663 Galland, B. C., & Mitchell, E. A. (2010). Helping children sleep. Archives of Disease in Childhood, Advance Online Publication. doi: 10.1136/adc.2010.162974 Galland, B. C., Tripp, E. G., Gray, A., & Taylor, B. J. (2010). Apnea-hypopnea indices and snoring in children diagnosed with ADHD: A matched case-control study. Sleep Breath, Advance Online Publication. doi: 10.1007/s11325-010-0357-0 Galland, B. C., Tripp, E. G., & Taylor, B. J. (2010). The sleep of children with attention deficit hyperactivity disorder on and off methylphenidate: A matched case-control study. Journal of Sleep Research, 19, 366-373. doi: 10.1111/j.1365- 2869.2009.00795.x Ganesamoorthy, D., Bruno, D. L., Schoumans, J., Storey, E., Delatycki, M. B., ..., Gardner, R. J. M., & Slater, H. (2009). Development of a multiplex ligation-dependent probe amplication assay for diagnosis and estimation of the frequency of Spinocerebellar Ataxia Type 15. Clinical Chemistry, 55(7), 1415-1418. doi: 10.1373/clinchem.2009.124958 Goulding, A., Taylor, R. W., Grant, A. M., Jones, S., Taylor, B. J., & Williams, S. (2009). Relationships of appendicular LMI and total body LMI to bone mass and physical activity levels in a birth cohort of New Zealand five-year olds. Bone, 45, 455- 459. doi: 10.1016/j.bone.2009.05.007 Hancox, R. J., Poulton, R., Welch, D., Olova, N., McLachlan, C. R., Greene, J. M., Sears, M. R., Caspi, A., Moffitt, T. E., Robertson, S. P., & Braithwaite, A. W. (2009). Accelerated decline in lung function in cigarette smokers is associated with TP53/MDM2 polymorphisms. Human Genetics, 126(4), 559-565. doi: 10.1007/s00439-009-0704-z Huber, C., ..., Robertson, S. P., Le Goff, C., Muda, A. O., Paterlini-Bréchot, P., Munnich, A., & Cormier-Daire, V. (2009). Identification of CANT1 mutations in Desbuquois dysplasia. American Journal of Human Genetics, 85(5), 706-710. doi: 10.1016/j.ajhg.2009.10.001 Jenkins, Z. A., van Kogelenberg, M., Morgan, T., Jeffs, A., Fukuzawa, R., Pearl, E., ..., & Robertson, S. P. (2009). Germline mutations in WTX cause a sclerosing skeletal dysplasia but do not predispose to tumorigenesis. Nature Genetics, 41(1), 95-100. doi: 10.1038/ng.270 Kapur, R. P., Robertson, S. P., Hannibal, M. C., Finn, L. S., Morgan, T., van Kogelenberg, M., & Loren, D. J. (2010). Diffuse abnormal layering of small intestinal smooth muscle is present in patients with FLNA mutations and X-linked intestinal pseudo-obstruction. American Journal of Surgical Pathology, 34(10), 1528-1543. doi: 10.1097/PAS.0b013e3181f0ae47 Kunac, D. L., Kennedy, J., Austin, N. C., & Reith, D. M. (2010). Risk factors for adverse drug events and medication errors in paediatric inpatients: Analysis by admission characteristics. Journal of Pharmacy Practice and Research, 40(4), 290-293. Kunac, D. L., Kennedy, J., Austin, N., & Reith, D. (2009). Incidence, preventability, and impact of adverse drug events (ADEs) and potential ADEs in hospitalized children in New Zealand: A prospective observational cohort study. Pediatric Drugs, 11(2), 153-160. doi: 10.2165/00148581-200911020-00005 Lawrence, J., & Smith, A. (2009). A place where it is not okay to hit children: The role of professionals. Social Policy Journal of New Zealand, 34, 113-123. Lugtenberg, D., Kleefstra, T., Oudakker, A. R., ..., van Kogelenberg, M., et al. (2009). Structural variation in Xq28: MECP2 duplications in 1% of patients with unexplained XLMR and in 2% of male patients with severe encephalopathy. European Journal of Human Genetics, 17(4), 444-453. doi: 10.1038/ejhg.2008.208 Lyons, M. J., Graham, Jr, J. M., Neri, G., ..., Robertson, S., et al. (2009). Clinical experience in the evaluation of 30 patients with a prior diagnosis of FG syndrome. Journal of Medical Genetics, 46(1), 9-13. doi: 10.1136/jmg.2008.060509 Masurel-Paulet, A., Haan, E., Thompson, E. M., Goizet, C., ..., Robertson, S., & Faivre, L. (2010). Lung disease associated with periventricular nodular heterotopia and a FLNA mutation. European Journal of Medical Genetics, Advance Online Publication. doi: 10.1016/j.ejmg.2010.09.010 McDonald, G., Davie, G., & Langley, J. (2009). Validity of police-reported information on injury severity for those hospitalized from motor vehicle traffic crashes. Traffic Injury Prevention, 10(2), 184-190. doi: 10.1080/15389580802593699 Miyahara, M., Butson, R., Cutfield, R., & Clarkson, J. E. (2009). A pilot study of family-focused tele-intervention for children with developmental coordination disorder: Development and lessons learned. Telemedicine Journal and e-Health, 15(7), 707-712. doi: 10.1089/tmj.2009.0022 Ragupathy, R., Tordoff, J., Norris, P., & Reith, D. (2010). Access to children’s medicines in the United Kingdom, Australia and New Zealand in 1998, 2002 and 2007. Pharmacy World and Science, 32, 386-393. doi: 10.1007/s11096-010-9383-z Reith, D., Medlicott, N. J., Kumara De Silva, R., Yang, L., Hickling, J., & Zacharias, M. (2009). Simultaneous modelling of the Michaelis-Menten kinetics of paracetamol sulphation and glucuronidation. Clinical and Experimental Pharmacology and Physiology, 36(1), 35-42. doi: 10.1111/j.1440-1681.2008.05029.x

182 RESEARCH REPORT 2009/2010 Reversade, B., Escande-Beillard, N., Dimopoulou, A., ..., Markie, D., Gray, M., Robertson, S., et al. (2009). Mutations in PYCR1 cause cutis laxa with progeroid features. Nature Genetics, 41(9), 1016-1021. doi: 10.1038/ng.413 Sawyer, G. M., Clark, A. R., Robertson, S. P., & Sutherland-Smith, A. J. (2009). Disease-associated substitutions in the filamin B actin binding domain confer enhanced actin binding affinity in the absence of major structural disturbance: Insights from the crystal structures of filamin B actin binding domains. Journal of Molecular Biology, 390(5), 1030-1047. doi: 10.1016/j. jmb.2009.06.009 Sherwin, C. M. T., Kostan, E., Broadbent, R. S., Medlicott, N. J., & Reith, D. M. (2009). Evaluation of the effect of intravenous volume expanders upon the volume of distribution of gentamicin in septic neonates. Biopharmaceutics & Drug Disposition, 30(5), 276-280. doi: 10.1002/bdd.666 Sherwin, C. M. T., McCaffrey, F., Broadbent, R. S., Reith, D. M., & Medlicott, N. J. (2009). Discrepancies between predicted and observed rates of intravenous gentamicin delivery for neonates. Journal of Pharmacy and Pharmacology, 61(4), 465-471. doi: 10.1211/jpp/61.04.0008 Storey, E., Bahlo, M., Fahey, M., Sisson, O., Lueck, C. J., & Gardner, R. J. M. (2009). A new dominantly inherited pure cerebellar ataxia, SCA 30. Journal of Neurology, Neurosurgery, and Psychiatry, 80, 408-411. doi: 10.1136/jnnp.2008.159459 Sun, Y., Almomani, R., Aten, E., ..., Robertson, S. P., et al. (2010). Terminal osseous dysplasia is caused by a single recurrent mutation in the FLNA gene. American Journal of Human Genetics, 87(1), 146-153. doi: 10.1016/j.ajhg.2010.06.008 Taylor, R. W., Brooking, L., Williams, S. M., Manning, P. J., Sutherland, W. H., Coppell, K. J., Tipene-Leach, D., Dale, K. S., McAuley, K. A., & Mann, J. I. (2010). Body mass index and waist circumference cutoffs to define obesity in indigenous New Zealanders. American Journal of Clinical Nutrition, 92, 390-397. doi: 10.3945/ajcn.2010.29317 Taylor, R. W., Brown, D., ..., Rose, E. A., Taylor, B. J., Meredith-Jones, K., Treacy, L., Ross, J., & Williams, S. M. (2010). Motivational interviewing for screening and feedback and encouraging lifestyle changes to reduce relative weight in 4-8 year old children: Design of the MInT study. BMC Public Health, 10, 271. doi: 10.1186/1471-2458-10-271 Taylor, R. W., Murdoch, L., Carter, P., Gerrard, D. F., Williams, S. M., & Taylor, B. J. (2009). Longitudinal study of physical activity and inactivity in preschoolers: The FLAME study. Medicine and Science in Sports and Exercise, 41(1), 96-102. Unger, S., Lausch, E., Rossi, A., ..., Robertson, S., et al. (2010). Phenotypic features of carbohydrate sulfotransferase 3 (CHST3) deficiency in 24 patients: Congenital dislocations and vertebral changes as principal diagnostic features. American Journal of Medical Genetics Part A, 152A(10), 2543-2549. doi: 10.1002/ajmg.a.33641 Wright, D. F. B., Al-Sallami, H. S., Jackson, P. M., & Reith, D. M. (2010). Falsely elevated vancomycin plasma concentrations sampled from central venous implantable catheters (portacaths). British Journal of Clinical Pharmacology, 70(5), 769-772. doi: 10.1111/j.1365-2125.2010.03749.x Yoshida, A., Maoate, K., Blakelock, R. T., Robertson, S., & Beasley, S. (2010). Long-term functional outcomes in children with Currarino syndrome. Pediatric Surgery International, 26, 677-681. doi: 10.1007/s00383-010-2615-4 Young, L., Lawes, F., Tordoff, J., Norris, P., & Reith, D. (2009). Access to prescribing information for paediatric medicines in the USA: Post-modernization. British Journal of Clinical Pharmacology, 67(3), 341-346. doi: 10.1111/j.1365-2125.2008.03356.x

Journal - Research Other Edmonds, L. (2010). Review of the book Current diagnosis and treatment: Pediatrics. Journal of Paediatrics and Child Health, 46(5), 283. doi: 10.1111/j.1440-1754.2010.01762.x Sherwin, C. M. T., Broadbent, R. S., Medlicott, N. J., & Reith, D. M. (2009). Individualised dosing of amikacin in neonates [Letter to the editor]. European Journal of Clinical Pharmacology, 65(12), 1267-1268. doi: 10.1007/s00228-009-0691-y Sherwin, C. M. T., Svahn, S., Van Der Linden, A., Broadbent, R. S., Medlicott, N. J., & Reith, D. M. (2009). Individualised dosing of amikacin in neonates: A pharmacokinetic/pharmacodynamic analysis. European Journal of Clinical Pharmacology, 65(7), 705-713. doi: 10.1007/s00228-009-0637-4

Journal - Professional & Other Non-Research Articles Broadbent, R. (2010). Re: AP-ROP in an infant with minimal oxygen exposure [Letter to the editor]. Journal of Paediatrics and Child Health, 46(4), 210-211. doi: 10.1111/j.1440-1754.2010.01760.x

Commissioned Report for External Body Craig, E., Anderson, P., & Jackson, C. (2009). The health status of children and young people in the Capital and Coast DHB. Commissioned by Capital and Coast DHB. Dunedin, New Zealand: New Zealand Child and Youth Epidemiology Service, 318p. Craig, E., Anderson, P., Taufa, S., & Jackson, C. (2009). The health status of Pacific children and young people in New Zealand. Commissioned by Ministry of Health. Dunedin, New Zealand: New Zealand Child and Youth Epidemiology Service, 381p. Craig, E., McDonald, G., Reddington, A., & Wicken, A. (2009). The determinants of health for children and young people in Auckland DHB. Commissioned by Auckland DHB. Dunedin, New Zealand: New Zealand Child and Youth Epidemiology Service, 338p. Craig, E., McDonald, G., Reddington, A., & Wicken, A. (2009). The determinants of health for children and young people in Canterbury. Commissioned by Canterbury DHB. Dunedin, New Zealand: New Zealand Child and Youth Epidemiology Service, 338p. Craig, E., McDonald, G., Reddington, A., & Wicken, A. (2009). The determinants of health for children and young people in Capital and Coast DHB. Commissioned by Capital and Coast DHB. Dunedin, New Zealand: New Zealand Child and Youth Epidemiology Service, 338p.

Division of HEALTH SCIENCES 183 Craig, E., McDonald, G., Reddington, A., & Wicken, A. (2009). The determinants of health for children and young people in Counties Manukau. Commissioned by Counties Manukau DHB. Dunedin, New Zealand: New Zealand Child and Youth Epidemiology Service, 338p. Craig, E., McDonald, G., Reddington, A., & Wicken, A. (2009). The determinants of health for children and young people in Hawke’s Bay. Commissioned by Hawke’s Bay DHB. Dunedin, New Zealand: New Zealand Child and Youth Epidemiology Service, 336p. Craig, E., McDonald, G., Reddington, A., & Wicken, A. (2009). The determinants of health for children and young people in Hutt Valley DHB. Commissioned by Hutt Valley DHB. Dunedin, New Zealand: New Zealand Child and Youth Epidemiology Service, 338p. Craig, E., McDonald, G., Reddington, A., & Wicken, A. (2009). The determinants of health for children and young people in Lakes DHB. Commissioned by Lakes DHB. Dunedin, New Zealand: New Zealand Child and Youth Epidemiology Service, 338p. Craig, E., McDonald, G., Reddington, A., & Wicken, A. (2009). The determinants of health for children and young people in MidCentral. Commissioned by MidCentral DHB. Dunedin, New Zealand: New Zealand Child and Youth Epidemiology Service, 338p. Craig, E., McDonald, G., Reddington, A., & Wicken, A. (2009). The determinants of health for children and young people in Nelson Marlborough. Commissioned by Nelson Marlborough DHB. Dunedin, New Zealand: New Zealand Child and Youth Epidemiology Service, 338p. Craig, E., McDonald, G., Reddington, A., & Wicken, A. (2009). The determinants of health for children and young people in Northland. Commissioned by Northland DHB. Dunedin, New Zealand: New Zealand Child and Youth Epidemiology Service, 336p. Craig, E., McDonald, G., Reddington, A., & Wicken, A. (2009). The determinants of health for children and young people in Otago. Commissioned by Otago DHB. Dunedin, New Zealand: New Zealand Child and Youth Epidemiology Service, 336p. Craig, E., McDonald, G., Reddington, A., & Wicken, A. (2009). The determinants of health for children and young people in Southland. Commissioned by Southland DHB. Dunedin, New Zealand: New Zealand Child and Youth Epidemiology Service, 338p. Craig, E., McDonald, G., Reddington, A., & Wicken, A. (2009). The determinants of health for children and young people in the Bay of Plenty. Commissioned by Bay of Plenty DHB. Dunedin, New Zealand: New Zealand Child and Youth Epidemiology Service, 338p. Craig, E., McDonald, G., Reddington, A., & Wicken, A. (2009). The determinants of health for children and young people in the Waikato. Commissioned by Waikato DHB. Dunedin, New Zealand: New Zealand Child and Youth Epidemiology Service, 338p. Craig, E., McDonald, G., Reddington, A., & Wicken, A. (2009). The determinants of health for children and young people in Waitemata DHB. Commissioned by Waitemata DHB. Dunedin, New Zealand: New Zealand Child and Youth Epidemiology Service, 338p. Craig, E., McDonald, G., Wicken, A., Reddington, A., & Taufa, S. (2010). The determinants of health for Pacific children and young people in New Zealand. Commissioned by Ministry of Health. Dunedin, New Zealand: New Zealand Child and Youth Epidemiology Service, 304p. Lawrence, J., & Smith, A. B. (2009). Discipline in context: Families’ disciplinary practices for children aged under five [Blue Skies Report No. 30/09]. Commissioned by Families Commission. Wellington, New Zealand: Families Commission, 48p.

Working Paper; Discussion Paper; Technical Report Horsburgh, S., Malik, M., Norris, P., Harrison-Woolrych, M., Tordoff, J., Becket, G., Herbison, P., Parkin, L., & Reith, D. (2009). Prescribing and dispensing data sources in New Zealand: Their usage and future directions [Technical Report No. 001/09]. Dunedin, New Zealand: chool of Pharmacy, University of Otago. (pp. 1-63).

University of Otago, Wellington Department of THE DEAN

Journal - Research Article Bland, M., & Gallagher, P. (2009). The impact of a change to assessment policy on students from a New Zealand School of Nursing. Nurse Education Today, 29(7), 722-730. doi: 10.1016/j.nedt.2009.02.015 Doudney, K., Harley, J. A., Pearson, J. F., Miller, A., Aitchison, A., Kennedy, M. A., Porter, R. J., Elmslie, J. L., & Joyce, P. R. (2009). Upstream genetic variant near INSIG2, influences response to carnitine supplementation in bipolar patients with valproate-induced weight gain. Acta Neuropsychiatrica, 21(3), 133-140. doi: 10.1111/j.1601-5215.2009.00379.x Gallagher, P. (2010). The role of the assessor in the assessment of practice: An alternative view. Medical Teacher, 32(10), e413-e416. doi: 10.3109/0142159X.2010.496010 Ousey, K., & Gallagher, P. (2010). The clinical credibility of nurse educators: Time the debate was put to rest. Nurse Education Today, 30, 662-665. doi: 10.1016/j.nedt.2009.12.021

Journal - Research Other Ousey, K., & Gallagher, P. (2010). A degree of experience. Nursing Standard, 24(50), 61.

184 RESEARCH REPORT 2009/2010 University of Otago, Wellington Department of Medicine

Edited Book - Research Howden-Chapman, P., Bennett, J., & Siebers, R. (Eds.). (2009). Do damp and mould matter? Health impacts of leaky homes. Wellington, New Zealand: Steele Roberts, 172p.

Chapter in Book - Research Crane, J. (2009). Mould and severe asthma. In P. Howden-Chapman, J. Bennett & R. Siebers (Eds.), Do damp and mould matter? Health impacts of leaky homes (pp. 24-32). Wellington, New Zealand: Steele Roberts. Shorter, C. (2009). Methods for measuring fungi indoors. In P. Howden-Chapman, J. Bennett & R. Siebers (Eds.), Do damp and mould matter? Health impacts of leaky homes (pp. 61-68). Wellington, New Zealand: Steele Roberts. Siebers, R. (2009). Fungal wall cells: b-glucan, a biomarker for mould exposure. In P. Howden-Chapman, J. Bennett & R. Siebers (Eds.), Do damp and mould matter? Health impacts of leaky homes (pp. 69-74). Wellington, New Zealand: Steele Roberts. Waipara, N. (2009). Issues of toxic rot contamination in leaky buildings, Stachybotrys chartarum and other toxigenic microbial contaminants. In P. Howden-Chapman, J. Bennett & R. Siebers (Eds.), Do damp and mould matter? Health impacts of leaky homes (pp. 44-48). Wellington, New Zealand: Steele Roberts. Wilson, N., Howden-Chapman, P., Wickens, K., & Crane, J. (2009). Indoor mould exposure and health. In P. Howden- Chapman, J. Bennett & R. Siebers (Eds.), Do damp and mould matter? Health impacts of leaky homes (pp. 19-23). Wellington, New Zealand: Steele Roberts.

Chapter in Book - Other Arroll, B., Fitton, A., & Mann, S. (2009). Pharmacotherapy: Lowering blood pressure. In R. Hobbs & B. Arroll (Eds.), Cardiovascular risk management (pp. 64-70). Chichester, UK: Wiley-Blackwell.

Journal - Research Article Aït-Khaled, N., Pearce, N., Anderson, H. R., Ellwood, P., Montefort, S., Shah, J., ISAAC Phase Three Study Group, including Crane, J., & Pattemore, P. (2009). Global map of the prevalence of symptoms of rhinoconjunctivitis in children: The International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three. Allergy, 64(1), 123-148. doi: 10.1111/j.1398-9995.2008.01884.x Alexander, H., Irwin, C., Purdie, G., & Hunn, M. (2010). Incidence and management of high grade glioma in Mäori and non- Mäori patients. Journal of Clinical Neuroscience, 17(9), 1144-1147. doi: 10.1016/j.jocn.2010.01.033 Asher, M. I., Stewart, A. W., Mallol, J., ..., ISAAC Phase One Study Group, including Crane, J., & Pattemore, P. (2010). Which population level environmental factors are associated with asthma, rhinoconjunctivitis and eczema? Review of the ecological analyses of ISAAC Phase One. Respiratory Research, 11, 8. Retrieved from http://respiratory-research.com/ content/11/1/8 Bakker, J., Campbell, A., & Neill, A. (2010). Randomised controlled trial of auto-adjusting positive airway pressure in morbidly obese patients requiring high therapeutic pressure delivery. Journal of Sleep Research, Advance Online Publication. doi: 10.1111/j.1365-2869.2010.00846.x Bakker, J., Campbell, A., & Neill, A. (2010). Randomized controlled trial comparing flexible and continuous positive airway pressure delivery: Effects on compliance, objective and subjective sleepiness and vigilance. Sleep, 33(4), 523-529. Bakker, J. P., Campbell, A. J., & Neill, A. M. (2010). Pulse wave analysis in a pilot randomised controlled trial of auto-adjusting and continuous positive airway pressure for obstructive sleep apnoea. Sleep and Breathing, Advance Online Publication. doi: 10.1007/s11325-010-0385-9 Bakker, J. P., & Marshall, N. S. (2010). Flexible pressure delivery modification of continuous positive airway pressure for obstructive sleep apnea does not improve compliance with therapy: Systematic review and meta-analysis. Chest, Advance Online Publication. doi: 10.1378/chest.10-2379 Barthow, C., Moss, C., McKinlay, E., McCullough, L., & Wise, D. (2009). To be involved or not: Factors that influence nurses’ involvement in providing treatment decisional support in advanced cancer. European Journal of Oncology Nursing, 13(1), 22-28. doi: 10.1016/j.ejon.2008.09.004 Braund, R., Hook, S. M., Greenhill, N., & Medlicott, N. J. (2009). Distribution of fibroblast growth factor-2 (FGF-2) within model excisional wounds following topical application. Journal of Pharmacy and Pharmacology, 61(2), 193-200. doi: 10.1211/jpp/61.02.0008 Burgess, D. C., Hunt, D., ..., Lehto, S., Mann, S., & Keech, A. C. (2010). Incidence and predictors of silent myocardial infarction in type 2 diabetes and the effect of fenofibrate: An analysis from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study. European Heart Journal, 31(1), 92-99. doi: 10.1093/eurheartj/ehp377 Caldwell, B., Burgess, C., & Crane, J. (2010). Randomized crossover trial of the acceptability of snus, nicotine gum, and Zonnic therapy for smoking reduction in heavy smokers. Nicotine & Tobacco Research, 12(2), 179-183. doi: 10.1093/ntr/ntp189 Caldwell, B., Dickson, S., Burgess, C., Siebers, R., Mala, S., Parkes, A., & Crane, J. (2009). A pilot study of nicotine delivery to smokers from a metered-dose inhaler. Nicotine and Tobacco Research, 11(4), 342-347. doi: 10.1093/ntr/ntp027 Camargo, Jr, C. A., Ingham, T., Wickens, K., Thadhani, R. I., Silvers, K. M., Epton, M. J., Town, G. I., Espinola, J. A., Crane, J., & New Zealand Asthma and Allergy Cohort Study Group (2010). Vitamin D status of newborns in New Zealand. British Journal of Nutrition, 104(7), 1051-1057. doi: 10.1017/S0007114510001674

Division of HEALTH SCIENCES 185 Campbell, A. J., Reynolds, G., Trengrove, H., & Neill, A. M. (2009). Mandibular advancement splint titration in obstructive sleep apnoea. Sleep and Breathing, 13(2), 157-162. doi: 10.1007/s11325-008-0230-6 Chang, A. Y., Marsh, S., Smith, N., & Neill, A. (2010). Long-term community non-invasive ventilation. Internal Medicine Journal, 40(11), 764-771. doi: 10.1111/j.1445-5994.2010.02171.x Dekker, J. W., Wickens, K., Black, P. C., Stanley, T. V., Mitchell, E. A., Fitzharris, P., Tannock, G. W., Purdie, G., & Crane, J. (2009). Safety aspects of probiotic bacterial strains Lactobacillus rhamnosus HN001 and Bifidobacterium animalis subsp. lactis HN019 in human infants aged 0-2 years. International Dairy Journal, 19(3), 149-154. doi: 10.1016/j. idairyj.2008.10.004 Elder, D. E., Campbell, A. J., Larsen, P. D., & Galletly, D. (2010). Respiratory variability in preterm and term infants: Effect of sleep state; position and age. Respiratory Physiology & Neurobiology, Advance Online Publication. doi: 10.1016/j. resp.2010.11.011 Elder, D. E., Larsen, P. D., Galletly, D. C., & Campbell, A. J. (2010). Cardioventilatory coupling in preterm and term infants: Effect of position and sleep state. Respiratory Physiology & Neurobiology, 174(1-2), 128-134. doi: 10.1016/j. resp.2010.05.012 Elder, D. E., Whale, J., Galletly, D., & Campbell, A. J. (2010). Respiratory events in preterm infants prior to discharge: With and without clinically concerning apnoea. Sleep and Breathing, Advance Online Publication. doi: 10.1007/s11325-010-0457-x Ellison-Loschmann, L., Pattemore, P. K., Asher, M. I., Clayton, T. O., Crane, J., Ellwood, P., MacKay, R. J., Mitchell, E. A., Moyes, C. D., Pearce, N., & Stewart, A. W. (2009). Ethnic differences in time trends in asthma prevalence in New Zealand: ISAAC Phases I and III. International Journal of Tuberculosis and Lung Disease, 13(6), 775-782. Ellwood, P., Asher, M. I., Stewart, A. W., ISAAC Phase III Study Group, including Crane, J., & Pattemore, P. (2010). The impact of the method of consent on response rates in the ISAAC time trends study. International Journal of Tuberculosis and Lung Disease, 14(8), 1059-1065. Ellwood, P., Williams, H., Aït-Khaled, N., Björkstén, B., Robertson, C., ISAAC Phase III Study Group, including Crane, J., & Pattemore, P. (2009). Translation of questions: The International Study of Asthma and Allergies in Childhood (ISAAC) experience. International Journal of Tuberculosis and Lung Disease, 13(9), 1174-1182. Eyers, S., Weatherall, M., Shirtcliffe, P., Perrin, K., & Beasley, R. (2010). The effect on mortality of antipyretics in the treatment of influenza infection: Systematic review and meta-analyis. Journal of the Royal Society of Medicine, 103(10), 403-411. doi: 10.1258/jrsm.2010.090441 Farquhar, H., Stewart, A., Mitchell, E., Crane, J., Eyers, S., Weatherall, M., & Beasley, R. (2010). The role of paracetamol in the pathogenesis of asthma. Clinical & Experimental Allergy, 40(1), 32-41. doi: 10.1111/j.1365-2222.2009.03378.x Farquhar, H., Weatherall, M., Wijesinghe, M., Perrin, K., Ranchord, A., Simmonds, M., & Beasley, R. (2009). Systematic review of studies of the effect of hyperoxia on coronary blood flow. American Heart Journal, 158(3), 371-377. doi: 10.1016/j. ahj.2009.05.037 Free, S., Howden-Chapman, P., Pierse, N., Viggers, H., the Housing, Heating and Health Study Research Team, including Nicholls, S., Bennett, J., Shields, D., Lloyd, B., Wickens, K., Baker, M., & Crane, J. (2010). More effective home heating reduces school absences for children with asthma. Journal of Epidemiology and Community Health, 64(5), 379-386. doi: 10.1136/jech.2008.086520 Gander, P., Hartley, L., Powell, D., Cabon, P., Hitchcock, E., Mills, A., & Popkin, S. (2010). Fatigue risk management: Organizational factors at the regulatory and industry/company level. Accident Analysis & Prevention, 43(2), 573-590. doi: 10.1016/j.aap.2009.11.007 Genuneit, J., Cantelmo, J. L., Weinmayr, G., ..., Crane, J., et al. (2009). A multi-centre study of candidate genes for wheeze and allergy: The International Study of Asthma and Allergies in Childhood Phase 2. Clinical and Experimental Allergy, 39(12), 1875-1888. Gillespie-Bennett, J., Pierse, N., Wickens, K., Crane, J., Howden-Chapman, P., the Housing, Heating and Health Study Research

Team, including Viggers, H., & Lloyd, B. (2010). The respiratory health effects of nitrogen dioxide (NO2) in children with asthma. European Respiratory Journal, Advance Online Publication. doi: 10.1183/09031936.00115409 Grainger, R., Taylor, W. J., Dalbeth, N., Perez-Ruiz, F., Singh, J. A., Waltrip, R. W., Schlesinger, N., et al. (2009). Progress in measurement instruments for acute and chronic gout studies. Journal of Rheumatology, 36(10), 2346-2355. doi: 10.3899/ jrheum.090371 Greenhill, N. S., & Davis, P. F. (2010). Anti-inflammatory activity of an oil derived fromPerna canaliculus (New Zealand green- lipped mussel). Internet Journal of Alternative Medicine, 8(1). Retrieved from http://www.ispub.com/journal/the_internet_ journal_of_alternative_medicine.html Hart, K., Weatherall, M., Shirtcliffe, P., & Beasley, R. (2009). Frequency of dosing and comparative doses of mometasone furoate: A meta-analysis. Respirology, 14(8), 1166-1172. doi: 10.1111/j.1440-1843.2009.01632.x Healy, B., Levin, E., Perrin, K., Weatherall, M., & Beasley, R. (2010). Prolonged work- and computer-related seated immobility and risk of venous thromboembolism. Journal of the Royal Society of Medicine, 103(11), 447-454. doi: 10.1258/ jrsm.2010.100155 Heyes, J. C., Siebers, R. W., Parkes, A., Pierse, N., & Crane, J. (2009). b-(1,3)-glucan levels and its determinants in New Zealand bedrooms. Journal of Asthma, 46(1), 64-66. doi: 10.1080/02770900802478326 Hollis-Moffatt, J. E., Chen-Xu, M., Topless, R., Dalbeth, N., Gow, P. J., Harrison, A. A., Highton, J., Jones, P. B. B., Nissen, M., Smith, M. D., van Rij, A., Jones, G. T., Stamp, L. K., & Merriman, T. R. (2010). Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: Confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance. Arthritis Research & Therapy, 12(3), R116. doi: 10.1186/ar3053

186 RESEARCH REPORT 2009/2010 Hollis-Moffatt, J. E., Merriman, M. E., Rodger, R. A., Rowley, K. A., Chapman, P. T., Dalbeth, N., Gow, P. J., Harrison, A. A., Highton, J., Jones, P. B. B., O’Donnell, J. L., Stamp, L. K., & Merriman, T. R. (2009). Evidence for association of an interleukin 23 receptor variant independent of the R381Q variant with rheumatoid arthritis. Annals of the Rheumatic Diseases, 68(8), 1340-1344. doi: 10.1136/ard.2008.090142 Hollis-Moffatt, J. E., Rowley, K. A., Phipps-Green, A. J., Merriman, M. E., Dalbeth, N., Gow, P., Harrison, A. A., Highton, J., Jones, P. B. B., Stamp, L. K., Harrison, P., Wordsworth, B. P., & Merriman, T. R. (2009). The ITGAV rs3738919 variant and susceptibility to rheumatoid arthritis in four Caucasian sample sets. Arthritis Research & Therapy, 11, R152. doi: 10.1186/ ar2828 Hollis-Moffatt, J. E., Xu, X., Dalbeth, N., Merriman, M. E., Topless, R., Waddell, C., Gow, P. J., Harrison, A. A., Highton, J., Jones, P. B. B., Stamp, L. K., & Merriman, T. R. (2009). Role of the urate transporter SLC2A9 gene in susceptibility to gout in New Zealand Mäori, Pacific Island, and Caucasian case-control sample sets. Arthritis and Rheumatism, 60(11), 3485- 3492. doi: 10.1002/art.24938 Jones, B., Ingham, T., Davies, C., & Cram, F. (2010). Whānau Tuatahi: Māori community partnership research using a Kaupapa Māori methodology. MAI Review, 3. Retrieved from http://www.review.mai.ac.nz/index.php/MR/issue/view/17 Judson, G., Bird, R., O’Connor, P., ..., Weatherall, M., Moriarty, H., & Robinson, G. (2010). Drug injecting in patients in New Zealand Methadone Maintenance Treatment programs: An anonymous survey. Drug and Alcohol Review, 29(1), 41-46. doi: 10.1111/j.1465-3362.2009.00080.x Lai, C. K. W., Beasley, R., Crane, J., Foliaki, S., Shah, J., & Weiland, S. (2009). Global variation in the prevalence and severity of asthma symptoms: Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax, 64(6), 476-483. doi: 10.1136/thx.2008.106609 Levin, E., Macintosh, D., Baker, T., Weatherall, M., & Beasley, R. (2009). Effect of sitting in ergonomic chairs on lower limb venous blood flow. Occupational Ergonomics, 8(2-3), 125-132. doi: 10.3233/OER-2009-0163 Mann, S. (2010). Diagnosing a heart attack: Are biomarkers the be-all and end-all? New Zealand Journal of Medical Laboratory Science, 64(2), 38-39. Martin, W. J., Grainger, R., Harrison, A., & Harper, J. L. (2010). Differences in MSU-induced superoxide responses by neutrophils from gout subjects compared to healthy controls and a role for environmental inflammatory cytokines and hyperuricemia in neutrophil function and survival. Journal of Rheumatology, 37(6), 1228-1235. doi: 10.3899/ jrheum.091080 McCullough, L., McKinlay, E., Barthow, C., Moss, C., & Wise, D. (2010). A model of treatment decision making when patients have advanced cancer: How do cancer treatment doctors and nurses contribute to the process? European Journal of Cancer Care, 19(4), 482-491. doi: 10.1111/j.1365-2354.2009.01074.x McKinney, C., Fanciulli, M., Merriman, M. E., Phipps-Green, A., ..., Harrison, A. A., Highton, J., Jones, P. B., Stamp, L. K., ..., & Merriman, T. R. (2010). Association of variation in Fcg receptor 3B gene copy number with rheumatoid arthritis in Caucasian samples. Annals of the Rheumatic Diseases, 69, 1711-1716. doi: 10.1136/ard.2009.123588 Merjava, S., Liskova, P., Sado, Y., Davis, P. F., Greenhill, N. S., & Jirsova, K. (2009). Changes in the localization of collagens IV and VIII in corneas obtained from patients with posterior polymorphous corneal dystrophy. Experimental Eye Research, 88(5), 945-952. doi: 10.1016/j.exer.2008.12.017 Mihaere, K. M., Harris, R., Gander, P. H., Reid, P. M., Purdie, G., Robson, B., & Neill, A. (2009). Obstructive sleep apnea in New Zealand adults: Prevalence and risk factors among Mäori and non-Mäori. Sleep, 32(7), 949-956. Mishra, P., & Stringer, M. D. (2010). Sciatic nerve injury from intramuscular injection: A persistent and global problem. International Journal of Clinical Practice, 64(11), 1573-1579. doi: 10.1111/j.1742-1241.2009.02177.x Perrin, K., Williams, M., Wijesinghe, M., James, K., Weatherall, M., & Beasley, R. (2010). Randomized controlled trial of adherence with single or combination inhaled corticosteroid/long-acting b-agonist inhaler therapy in asthma. Journal of Allergy and Clinical Immunology, 126(3), 505-510. doi: 10.1016/j.jaci.2010.06.033 Phipps-Green, A. J., Hollis-Moffatt, J. E., Dalbeth, N., Merriman, M. E., Topless, R., Gow, P. J., Harrison, A. A., Highton, J., Jones, P. B. B., Stamp, L. K., & Merriman, T. R. (2010). A strong role for the ABCG2 gene in susceptibility to gout in New Zealand Pacific Island and Caucasian, but not Mäori, case and control sample sets. Human Molecular Genetics, 19(24), 4813-4819. doi: 10.1093/hmg/ddq412 Purdie, G., Harrison, A., & Purdie, D. (2009). Prevalence of Raynaud’s phenomenon in the adult New Zealand population. New Zealand Medical Journal, 122(1306). Retrieved from http://www.nzma.org.nz/journal/122-1306/3890/ Rhodes, B., Merriman, M. E., Harrison, A., Nissen, M. J., Smith, M., Stamp, L., Steer, S., Merriman, T. R., & Vyse, T. J. (2010). A genetic association study of serum acute-phase C-reactive protein levels in rheumatoid arthritis: Implications for clinical interpretation. PLoS Medicine, 7(9), e1000341. doi: 10.1371/journal.pmed.1000341 Sapre, N., Mann, S., & Elley, C. R. (2009). Doctors’ perceptions of the prognostic benefit of statins in patients who have had myocardial infarction. Internal Medicine Journal, 39(5), 277-282. doi: 10.1111/j.1445-5994.2008.01729.x Schultz, M., Gearry, R., Walmsley, R., Day, A. S., Fraser, A., Wyeth, J., Barclay, M., Clover, G., & Whiteside, C. (2010). New Zealand Society of Gastroenterology statement on the use of biological therapy in inflammatory bowel disease. New Zealand Medical Journal, 123(1314). Retrieved from http://www.nzma.org.nz/journal/archive.php Siebers, R., Holt, S., Healy, B., Beasley, R., & Burgess, C. (2009). High blood pressure advice given by natural health food stores. New Zealand Medical Journal, 122(1293). Retrieved from http://www.nzma.org.nz/journal/122-1293/3566/ Silvers, K. M., Frampton, C. M., Wickens, K., Epton, M. J., Pattemore, P. K., Ingham, T., Fishwick, D., Crane, J., Town, G. I., & New Zealand Asthma and Allergy Cohort Study Group (2009). Breastfeeding protects against adverse respiratory outcomes at 15 months of age. Maternal and Child Nutrition, 5(3), 243-250. doi: 10.1111/j.1740-8709.2008.00169.x

Division of HEALTH SCIENCES 187 Sinnott, A. K., Brander, P., Siegert, R. J., Rothwell, A. G., & De Jong, G. (2009). Life impacts following reconstructive hand surgery for tetraplegia. Topics in Spinal Cord Injury Rehabilitation, 15(2), 90-97. doi: 10.1310/sci1502-90 Taylor, B. V., Pearson, J. F., Clarke, G., Mason, D. F., Abernethy, D. A., Willoughby, E., & Sabel, C. (2010). MS prevalence in New Zealand, an ethnically and latitudinally diverse country. Multiple Sclerosis, 16(12), 1422-1431. doi: 10.1177/1352458510379614 Taylor, W. J., Shewchuk, R., Saag, K. G., Schumacher, H. R., Singh, J. A., Grainger, R., et al. (2009). Toward a valid definition of gout flare: Results of consensus exercises using Delphi methodology and cognitive mapping. Arthritis & Rheumatism, 61(4), 535-543. doi: 10.1002/art.24166 Tobias, M., Yeh, L-C., Wright, C., Riddell, T., Chan, W. C., Jackson, R., & Mann, S. (2009). The burden of coronary heart disease in Mäori: Population-based estimates for 2000-02. Australian and New Zealand Journal of Public Health, 33(4), 384-387. doi: 10.1111/j.1753-6405.2009.00412.x Tweed, M., & Ingham, C. (2009). How do assessors make decisions on marking and standard setting for observed consultations? Focus on Health Professional Education, 10(3), 39-50. Tweed, M., & Ingham, C. (2010). Observed consultation: Confidence and accuracy of assessors. Advances in Health Sciences Education, 15, 31-43. doi: 10.1007/s10459-009-9163-5 Tweed, M., & Wilkinson, T. (2009). A randomized controlled trial comparing instructions regarding unsafe response options in a MCQ examination. Medical Teacher, 31(1), 51-54. doi: 10.1080/01421590802146018 Verrall, A., Norton, K., Rooker, S., Dee, S., Olsen, L., Tan, C. E., Paull, S., Allen, R., & Blackmore, T. K. (2010). Hospitalizations for pandemic (H1N1) 2009 among Maori and Pacific Islanders, New Zealand. Emerging Infectious Diseases, 16(1), 100-102. doi: 10.3201/eid1601.090994 Wan Taib, W. R., Smyth, D. J., Merriman, M. E., Dalbeth, N., Gow, P. J., Harrison, A. A., Highton, J., Jones, P. B. B., Stamp, L., Steer, S., Todd, J. A., & Merriman, T. R. (2010). The PTPN22 locus and rheumatoid arthritis: No evidence for an effect on risk independent of Arg620Trp. PLoS ONE, 5(10), e13544. doi: 10.1371/journal.pone.0013544 Weatherall, M., Clay, J., James, K., Perrin, K., Shirtcliffe, P., & Beasley, R. (2009). Dose-response relationship of inhaled corticosteroids and cataracts: A systematic review and meta-analysis. Respirology, 14(7), 983-990. doi: 10.1111/j.1440- 1843.2009.01589.x Weatherall, M., Marsh, S., Shirtcliffe, P., Williams, M., Travers, J., & Beasley, R. (2009). Quality of life measured by the St George’s Respiratory Questionnaire and spirometry. European Respiratory Journal, 33(5), 1025-1030. doi: 10.1183/09031936.00116808 Weatherall, M., Travers, J., Shirtcliffe, P. M., Marsh, S. E., Williams, M. V., Nowitz, M. R., Aldington, S., & Beasley, R. (2009). Distinct clinical phenotypes of airways disease defined by cluster analysis. European Respiratory Journal, 34(4), 812-818. doi: 10.1183/09031936.00174408 Wickens, K., Beasley, R., Town, G. I., Epton, M., Pattemore, P., Ingham, T., Crane, J., & New Zealand Asthma and Allergy Cohort Study Group (2010). The effects of early and late paracetamol exposure on asthma and atopy: A birth cohort. Clinical & Experimental Allergy, Advance Online Publication. doi: 10.1111/j.1365-2222.2010.03610.x Wijesinghe, M., Shirtcliffe, P., Perrin, K., Healy, B., James, K., Weatherall, M., & Beasley, R. (2010). An audit of the effect of oxygen prescription charts on clinical practice. Postgraduate Medical Journal, 86(1012), 89-93. doi: 10.1136/ pgmj.2009.087528 Wijesinghe, M., Weatherall, M., Perrin, K., Crane, J., & Beasley, R. (2009). International trends in asthma mortality rates in the 5- to 34-year age group: A call for closer surveillance. Chest, 135(4), 1045-1049. doi: 10.1378/chest.08-2082 Wilkinson, T. J., Weller, J. M., McKimm, J., O’Connor, B. J., ..., Tweed, M. J., & Wearn, A. M. (2010). Programmatic research in New Zealand medical education: A national collaboration. New Zealand Medical Journal, 123(1318). Retrieved from http://www.nzma.org.nz/journal/123-1318/4210/ Wu, F. F-S., Chang, C-F., Wu, M-W., Pierse, N., & Siebers, R. (2010). Prevalence of macrocytosis in patients with chronic obstructive pulmonary disease. New Zealand Journal of Medical Laboratory Science, 64, 86-87. Wu, F. F-S., Siebers, R., Chang, C-F., Hsieh, S-W., Wu, M-W., Chen, C-Y., Pierse, N., & Crane, J. (2009). Indoor allergens and microbial bio-contaminants in homes of asthmatic children in Central Taiwan. Journal of Asthma, 46(7), 745-749. doi: 10.1080/02770900903082597 Wu, F. F-S., Wu, M-W., Chang, C-F., Lai, S-M., Pierse, N., Crane, J., & Siebers, R. (2010). Endotoxin and b-(1,3)-glucan levels in automobiles: A pilot study. Annals of Agricultural and Environmental Medicine, 17(2), 327-330.

Journal - Research Other Bagg, W., ..., Reid, J. J., Rudland, J., Tweed, M. J., & Wilkinson, T. J. (2010). Setting up new learning environments in regional and rural areas. New Zealand Medical Journal, 123(1312). Retrieved from http://www.nzma.org.nz/journal/123-1312/4061/ Beasley, R., Clayton, T., Crane, J., von Mutius, E., & Lai, C. K. W. (2009). [Authors’ reply to Paracetamol as a risk factor for allergic disorders ]. The Lancet, 373(9658), 120-121. doi: 10.1016/S0140-6736(09)60031-3 Beasley, R., Perrin, K., Weatherall, M., & Wijesinghe, M. (2010). Call for withdrawal of laba single-therapy inhaler in asthma [Comment]. The Lancet, 376(9743), 750-751. doi: 10.1016/S0140-6736(10)61158-0 Beasley, R., Weatherall, M., Travers, J., & Shirtcliffe, P. (2009). Time to define the disorders of the syndrome of COPD [Comment]. Lancet, 374(9691), 670-672. Farquhar, H., Crane, J., Mitchell, E. A., Eyers, S., & Beasley, R. (2009). The acetaminophen and asthma hypothesis 10 years on: A case to answer [Editorial]. Journal of Allergy and Clinical Immunology, 124(4), 649-651. doi: 10.1016/j.jaci.2009.07.037

188 RESEARCH REPORT 2009/2010 Foo, J., Toomath, R., Wickremesekera, S. K., Bann, S., & Stubbs, R. (2010). Bariatric surgery: A dilemma for the health system? [Editorial]. New Zealand Medical Journal, 123(1311). Retrieved from http://www.nzmj.org/journal/123-1311/ Grimwood, K., Kidd, T. J., & Tweed, M. (2009). Successful treatment of cepacia syndrome [Letter to the editor]. Journal of Cystic Fibrosis, 8(4), 291-293. doi: 10.1016/j.jcf.2009.04.002 Holt, S., Helm, C., Corin, A., Williams, M., & Weatherall, M. (2009). A pilot study of the efficacy of a vitamin C-containing showerhead on symptoms of eczema [Letter]. New Zealand Medical Journal, 122(1300). Retrieved from http://www.nzma. org.nz/journal/archive.shtml Islam, S., & Hampton, N. (2009). Gastrointestinal: Use of a second endoscope to free a jammed stitch cutter [Education & Imaging]. Journal of Gastroenterology and Hepatology, 24(5), 931. doi: 10.1111/j.1440-1746.2009.05890.x Low, I., Ch’ng, S., Ng, D., Sullivan, M., Brasch, H., Davis, P., & Tan, S. T. (2009). HER2 polysomy in aggresive head and neck cutaneous squamous cell carcinoma [Correspondence]. Human Pathology, 40(6), 902-903. doi: 10.1016/j. humpath.2008.12.012 Mann, S. (2009). Poster boarding [Letter]. British Medical Journal, 338(7689), 09598146. doi: 10.1136/bmj.b193 Phipps-Green, A. J., Topless, R. K. G., Merriman, M. E., Dalbeth, N., Gow, P. J., Harrison, A. A., Highton, J., Jones, P. B. B., Stamp, L. K., Harrison, P., Wordsworth, B. P., & Merriman, T. R. (2009). No evidence for association of the systemic lupus erythematosus-associated ITGAM variant, R77H, with rheumatoid arthritis in the Caucasian population [Letter to the editor]. Rheumatology, 48(12), 1614-1615. doi: 10.1093/rheumatology/kep254 Sellman, D., Connor, J., Robinson, G., & Jackson, R. (2009). Alcohol cardio-protection has been talked up. New Zealand Medical Journal, 122(1303). Retrieved from http://www.nzma.org.nz/journal/archive.shtml Siebers, R. (2010). Comment on ²Prevalence and risk factors for allergic rhinitis in primary school children in Budapest² By Monika Sultesz et al. [Int. J. Pediatr. Otorhinolaryngol. 74 (2010) 503-509] [Letter to the Editor]. International Journal of Pediatric Otorhinolaryngology, Advance Online Publication. doi: 10.1016/j.ijporl.2010.07.017 Tweed, M. J., Bagg, W., Child, S., Wilkinson, T. J., & Weller, J. M. (2010). How the trainee intern (TI) year can ease the transition from undergraduate education to postgraduate practice. New Zealand Medical Journal, 123(1318). Retrieved from http://www.nzma.org.nz/journal/archive.php Weatherall, M., Shirtcliffe, P., Travers, J., & Beasley, R. (2010). Use of cluster analysis to define COPD phenotypes [Editorial]. European Respiratory Journal, 36(3), 472-474. doi: 10.1183/09031936.00035210 Weatherall, M., Travers, J., Shirtcliffe, P., Marsh, S., Williams, M., Nowitz, M., Aldington, S., & Beasley, R. (2010). Distinct clinical phenotypes of airways disease: A primary-care clinician perspective [Reply to letter to the editor]. European Respiratory Journal, 35(2), 459-460. doi: 10.1183/09031936.00167309

Journal - Professional & Other Non-Research Articles Mann, S. (2009). [Independent commentary of published medical research]. Cardiology Research Review, (17). Retrieved from http://www.researchreview.co.nz/ Mann, S. (2009). [Independent commentary of published medical research]. Cardiology Research Review, (19). Retrieved from http://www.researchreview.co.nz/ Mann, S. (2009). [Independent commentary of published medical research]. Cardiology Research Review, (20). Retrieved from http://www.researchreview.co.nz/ Mann, S. (2009). [Independent commentary of published medical research]. Cardiology Research Review, (21). Retrieved from http://www.researchreview.co.nz/ Mann, S. (2009). [Independent commentary of published medical research]. Cardiology Research Review, (22). Retrieved from http://www.researchreview.co.nz/ Mann, S. (2009). [Independent commentary of published medical research]. Cardiology Research Review, (23). Retrieved from http://www.researchreview.co.nz/ Mann, S. (2009). [Independent commentary of published medical research]. Cardiology Research Review, (24). Retrieved from http://www.researchreview.co.nz/ Mann, S. (2009). [Independent commentary of published medical research]. Cardiology Research Review, (25). Retrieved from http://www.researchreview.co.nz/ Mann, S. (2009). [Independent commentary of published medical research]. Cardiology Research Review, (26). Retrieved from http://www.researchreview.co.nz/ Mann, S. (2009). Hypertension and CVD risk [How to treat]. New Zealand Doctor, (November), 25-30. Mann, S. (2009). Stable angina pectoris [How to treat]. New Zealand Doctor, (March), 17-24. Siebers, R. (2009). What happens to your article at the journal? [Editorial]. New Zealand Journal of Medical Laboratory Science, 63(3), 71. Siebers, R. (2010). [Editor’s comments on conflict of interest editorial Conflict of interest in peer-reviewed medical journals: The World Association of Medical Editors (WAME) position on a challenging problem]. New Zealand Journal of Medical Laboratory Science, 64(1). Siebers, R. (2010). How to write a laboratory-based case study for the journal. New Zealand Journal of Medical Laboratory Science, 64(1), 22-23. Tweed, M., & Wilkinson, T. (2009). The seven deadly sins of assessment [Assessment]. Clinical Teacher, 6(3), 164-166. doi: 10.1111/j.1743-498X.2009.00293.x Tweed, M., & Wilkinson, T. (2010). Should there be borderline candidates or should there be a zone of uncertainty around assessment decisions? [Letter to the editor]. Medical Teacher, 32(10), 869. doi: 10.3109/0142159X.2010.524520

Division of HEALTH SCIENCES 189 Reference Number: 0020100845 Tay, J., Ingham, T. R., Jones, B., Pierse, N., & Burgess, C. (2010, July). Taste perceptions of salbutamol-containing inhalers: A randomised crossover trial. Poster session presented at the 16th World Congress on Basic and Clinical Pharmacology, Copenhagen, Denmark.

Rehabilitation Teaching and Research Unit

Journal - Research Article Brown, M., Dean, S., Hay-Smith, E. J. C., Taylor, W., & Baxter, G. D. (2010). Musculoskeletal pain and treatment choice: An exploration of illness perceptions and choices of conventional or complementary therapies. Disability and Rehabilitation, 32(20), 1645-1657. doi: 10.3109/09638281003649896 Chiarelli, P., & Weatherall, M. (2010). The link between chronic conditions and urinary incontinence. Australian and New Zealand Continence Journal, 16(1), 7-14. Dunn, J. A., Hay-Smith, E. J. C., Whitehead, L. C., Keeling, S., & Rothwell, A. G. (2010). Upper limb reconstructive surgery uptake for persons with tetraplegia in New Zealand: A retrospective case review 2001-2005. Spinal Cord, Advance Online Publication. doi: 10.1038/sc.2010.15 Eyers, S., Weatherall, M., Shirtcliffe, P., Perrin, K., & Beasley, R. (2010). The effect on mortality of antipyretics in the treatment of influenza infection: Systematic review and meta-analyis. Journal of the Royal Society of Medicine, 103(10), 403-411. doi: 10.1258/jrsm.2010.090441 Farquhar, H., Stewart, A., Mitchell, E., Crane, J., Eyers, S., Weatherall, M., & Beasley, R. (2010). The role of paracetamol in the pathogenesis of asthma. Clinical & Experimental Allergy, 40(1), 32-41. doi: 10.1111/j.1365-2222.2009.03378.x Farquhar, H., Weatherall, M., Wijesinghe, M., Perrin, K., Ranchord, A., Simmonds, M., & Beasley, R. (2009). Systematic review of studies of the effect of hyperoxia on coronary blood flow. American Heart Journal, 158(3), 371-377. doi: 10.1016/j. ahj.2009.05.037 Grainger, R., Taylor, W. J., Dalbeth, N., Perez-Ruiz, F., Singh, J. A., Waltrip, R. W., Schlesinger, N., et al. (2009). Progress in measurement instruments for acute and chronic gout studies. Journal of Rheumatology, 36(10), 2346-2355. doi: 10.3899/ jrheum.090371 Gregg, C. D., Dean, S., & Schneiders, A. G. (2009). Variables associated with active spondylolysis. Physical Therapy in Sport, 10, 121-124. doi: 10.1016/j.ptsp.2009.08.001 Hart, K., Weatherall, M., Shirtcliffe, P., & Beasley, R. (2009). Frequency of dosing and comparative doses of mometasone furoate: A meta-analysis. Respirology, 14(8), 1166-1172. doi: 10.1111/j.1440-1843.2009.01632.x Healy, B., Beasley, R., & Weatherall, M. (2010). Venous thromboembolism following prolonged cast immobilisation for injury to the tendo Achillis. Journal of Bone and Joint Surgery, 92B(5), 646-650. doi: 10.1302/0301-620X.92B5.23241 Healy, B., Levin, E., Perrin, K., Weatherall, M., & Beasley, R. (2010). Prolonged work- and computer-related seated immobility and risk of venous thromboembolism. Journal of the Royal Society of Medicine, 103(11), 447-454. doi: 10.1258/ jrsm.2010.100155 Herbison, P., Hay-Smith, J., & Gillespie, W. J. (2010). Meta-analyses of small numbers of trials often agree with longer-term results. Journal of Clinical Epidemiology, Advance Online Publication. doi: 10.1016/j.jclinepi.2010.02.017 Herbison, P., Hay-Smith, J., Paterson, H., Ellis, G., & Wilson, D. (2009). Research priorities in urinary incontinence: Results from citizens’ juries. BJOG, 116(5), 713-718. doi: 10.1111/j.1471-0528.2008.02093.x Imamura, M., Abrams, P., Bain, C., Buckley, B., Cardozo, L., ..., Hay-Smith, J., et al. (2010). Systematic review and economic modelling of the effectiveness and cost-effectiveness of non-surgical treatments for women with stress urinary incontinence. Health Technology Assessment, 14(40). doi: 10.3310/hta14400 Judson, G., Bird, R., O’Connor, P., ..., Weatherall, M., Moriarty, H., & Robinson, G. (2010). Drug injecting in patients in New Zealand Methadone Maintenance Treatment programs: An anonymous survey. Drug and Alcohol Review, 29(1), 41-46. doi: 10.1111/j.1465-3362.2009.00080.x Kirchberger, I., Biering-Sørensen, F., Charlifue, S., ..., Sinnott, A., et al. (2010). Identification of the most common problems in functioning of individuals with spinal cord injury using the International Classification of Functioning, Disability and Health. Spinal Cord, 48(3), 221-229. doi: 10.1038/sc.2009.116 Kirchberger, I., Sinnott, A., Charlifue, S., Kovindha, A., Lüthi, H., Campbell, R., Zwecker, M., Scheuringer, M., & Cieza, A. (2010). Functioning and disability in spinal cord injury from the consumer perspective: An international qualitative study using focus groups and the ICF. Spinal Cord, 48(8), 603-613. doi: 10.1038/sc.2009.184 Levack, W. M. M., Kayes, N. M., & Fadyl, J. K. (2010). Experience of recovery and outcome following traumatic brain injury: A metasynthesis of qualitative research. Disability and Rehabilitation, 32(12), 1-14. doi: 10.3109/09638281003775394 Levack, W. M. M., Siegert, R. J., Dean, S. G., & McPherson, K. M. (2009). Goal planning for adults with acquired brain injury: How clinicians talk about involving family. Brain Injury, 23(3), 192-202. doi: 10.1080/02699050802695582 Levin, E., Macintosh, D., Baker, T., Weatherall, M., & Beasley, R. (2009). Effect of sitting in ergonomic chairs on lower limb venous blood flow. Occupational Ergonomics, 8(2-3), 125-132. doi: 10.3233/OER-2009-0163 Lord, S. E., Weatherall, M., & Rochester, L. (2010). Community ambulation in older adults: Which internal characteristics are important? Archives of Physical Medicine and Rehabilitation, 91(3), 378-383. doi: 10.1016/j.apmr.2009.11.008 Lord, S., Rochester, L., Hetherington, V., Allcock, L. M., & Burn, D. (2010). Executive dysfunction and attention contribute to gait interference in ‘off’ state Parkinson’s Disease. Gait and Posture, 31, 169-174. doi: 10.1016/j.gaitpost.2009.09.019

190 RESEARCH REPORT 2009/2010 McPherson, K. M., Kayes, N., Weatherall, M., & Goals-SR Research Group (2009). A pilot study of self-regulation informed goal setting in people with traumatic brain injury. Clinical Rehabilitation, 23, 296-309. doi: 10.1177/0269215509102980 McPherson, K. M., Taylor, W. J., & Leplege, A. (2010). Rehabilitation outcomes: Values, methodologies and applications. Disability and Rehabilitation, 32(12), 961-964. doi: 10.3109/09638281003672393 Parekh, K., & Taylor, W. J. (2010). The Patient Activity Scale-II is a generic indicator of active disease in patients with rheumatic disorders. Journal of Rheumatology, 37(9), 1932-1934. doi: 10.3899/jrheum.100008 Perrin, K., Williams, M., Wijesinghe, M., James, K., Weatherall, M., & Beasley, R. (2010). Randomized controlled trial of adherence with single or combination inhaled corticosteroid/long-acting b-agonist inhaler therapy in asthma. Journal of Allergy and Clinical Immunology, 126(3), 505-510. doi: 10.1016/j.jaci.2010.06.033 Perry, M. A., Hendrick, P. A., Hale, L., Baxter, G. D., Milosavljevic, S., Dean, S. G., McDonough, S. M., & Hurley, D. A. (2010). Utility of the RT3 triaxial accelerometer in free living: An investigation of adherence and data loss. Applied Ergonomics, 41, 469-476. doi: 10.1016/j.apergo.2009.10.001 Playford, E. D., Siegert, R. J., Levack, W., & Freeman, J. (2009). Areas of consensus and controversy about goal setting in rehabilitation: A conference report. Clinical Rehabilitation, 23(4), 334-344. doi: 10.1177/0269215509103506 Ritchlin, C. T., Kavanaugh, A., Gladman, D. D., ..., Taylor, W. J., et al, & Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) (2009). Treatment recommendations for psoriatic arthritis. Annals of the Rheumatic Diseases, 68(9), 1387-1394. doi: 10.1136/ard.2008.094946 Robinson, P. C., & Taylor, W. J. (2010). Time to treatment in rheumatoid arthritis: Factors associated with time to treatment initiation and urgent triage assessment of general practitioner referrals. Journal of Clinical Rheumatology, Advance Online Publication. doi: 10.1097/RHU.0b013e3181eeb499 Rudwaleit, M., & Taylor, W. J. (2010). Classification criteria for psoriatic arthritis and ankylosing spondylitis/axial spondyloarthritis. Best Practice and Research: Clinical Rheumatology, 24(5), 589-604. doi: 10.1016/j.berh.2010.05.007 Sinnott, A. K., Brander, P., Siegert, R. J., Rothwell, A. G., & De Jong, G. (2009). Life impacts following reconstructive hand surgery for tetraplegia. Topics in Spinal Cord Injury Rehabilitation, 15(2), 90-97. doi: 10.1310/sci1502-90 Snell, D. L., Siegert, R. J., Hay-Smith, E. J. C., & Surgenor, L. J. (2010). An examination of the factor structure of the Revised Illness Perception Questionnaire modified for adults with mild traumatic brain injury. Brain Injury, 24(13-14), 1595-1605. doi: 10.3109/02699052.2010.523048 Snell, D. L., Surgenor, L. J., Hay-Smith, E. J. C., & Siegert, R. J. (2009). A systematic review of psychological treatments for mild traumatic brain injury: An update on the evidence. Journal of Clinical and Experimental Neuropsychology, 31(1), 20-38. doi: 10.1080/13803390801978849 Tan, Y. M., Østergaard, M., Doyle, A., Dalbeth, N., Lobo, M., Reeves, Q., Robinson, E., Taylor, W. J., et al. (2009). MRI bone oedema scores are higher in the arthritis mutilans form of psoriatic arthritis and correlate with high radiographic scores for joint damage. Arthritis Research & Therapy, 11(1). doi: 10.1186/ar2586 Taylor, W. J., & Laking, G. (2010). Value for money: Recasting the problem in terms of dynamic access prioritisation. Disability and Rehabilitation, 32(12), 1020-1027. doi: 10.3109/09638281003775535 Taylor, W. J., Mease, P. J., Adebajo, A., Nash, P. J., Feletar, M., & Gladman, D. D. (2010). Effect of psoriatic arthritis according to the affected categories of the international classification of functioning, disability and health. Journal of Rheumatology, 37(9), 1885-1891. doi: 10.3899/jrheum.091315 Taylor, W. J., Shewchuk, R., Saag, K. G., Schumacher, H. R., Singh, J. A., Grainger, R., et al. (2009). Toward a valid definition of gout flare: Results of consensus exercises using Delphi methodology and cognitive mapping. Arthritis & Rheumatism, 61(4), 535-543. doi: 10.1002/art.24166 Thompson, I., Williams, G., Caldwell, B., ..., Weatherall, M., et al. (2010). Randomised double-blind, placebo-controlled trial of the effects of the ‘party pills’ BZP/TFMPP alone and in combination with alcohol. Journal of Psychopharmacology, 24(9), 1299-1308. doi: 10.1177/0269881109102608 Weatherall, M., Clay, J., James, K., Perrin, K., Shirtcliffe, P., & Beasley, R. (2009). Dose-response relationship of inhaled corticosteroids and cataracts: A systematic review and meta-analysis. Respirology, 14(7), 983-990. doi: 10.1111/j.1440- 1843.2009.01589.x Weatherall, M., Marsh, S., Shirtcliffe, P., Williams, M., Travers, J., & Beasley, R. (2009). Quality of life measured by the St George’s Respiratory Questionnaire and spirometry. European Respiratory Journal, 33(5), 1025-1030. doi: 10.1183/09031936.00116808 Weatherall, M., Pickering, R. M., & Harris, S. (2009). Graphical sensitivity analysis with different methods of imputation for a trial with probable non-ignorable missing data. Australian & New Zealand Journal of Statistics, 51(4), 397-413. doi: 10.1111/j.1467-842X.2009.00553.x Weatherall, M., Travers, J., Shirtcliffe, P. M., Marsh, S. E., Williams, M. V., Nowitz, M. R., Aldington, S., & Beasley, R. (2009). Distinct clinical phenotypes of airways disease defined by cluster analysis. European Respiratory Journal, 34(4), 812-818. doi: 10.1183/09031936.00174408 Weatherall, M., Wijesinghe, M., Perrin, K., & Beasley, R. (2010). Long-acting beta-agonists and asthma death: How useful are different study designs to evaluate the potential association? Journal of Asthma, 47(4), 434-438. doi: 10.3109/02770900903556439 Weatherall, M., Wijesinghe, M., Perrin, K., Harwood, M., & Beasley, R. (2010). Meta-analysis of the risk of mortality with salmeterol and the effect of concomitant inhaled corticosteroid therapy. Thorax, 65(1), 39-43. doi: 10.1136/ thx.2009.116608

Division of HEALTH SCIENCES 191 Wijesinghe, M., Perrin, K., Ranchord, A., Simmonds, M., Weatherall, M., & Beasley, R. (2009). Routine use of oxygen in the treatment of myocardial infarction: Systematic review. Heart, 95(3), 198-202. doi: 10.1136/hrt.2008.148742 Wijesinghe, M., Shirtcliffe, P., Perrin, K., Healy, B., James, K., Weatherall, M., & Beasley, R. (2010). An audit of the effect of oxygen prescription charts on clinical practice. Postgraduate Medical Journal, 86(1012), 89-93. doi: 10.1136/ pgmj.2009.087528 Wijesinghe, M., Weatherall, M., Perrin, K., & Beasley, R. (2009). Honey in the treatment of burns: A systematic review and meta-analysis of its efficacy. New Zealand Medical Journal, 122(1295). Retrieved from http://www.nzma.org.nz/ journal/122-1295/3610/ Wijesinghe, M., Weatherall, M., Perrin, K., Crane, J., & Beasley, R. (2009). International trends in asthma mortality rates in the 5- to 34-year age group: A call for closer surveillance. Chest, 135(4), 1045-1049. doi: 10.1378/chest.08-2082 Wijesinghe, M., Weatherall, M., Perrin, K., Harwood, M., & Beasley, R. (2009). Risk of mortality associated with formoterol: A systematic review and meta-analysis. European Respiratory Journal, 34(4), 803-811. doi: 10.1183/09031936.00159708

Journal - Research Other Beasley, R., Perrin, K., Weatherall, M., & Wijesinghe, M. (2010). Call for withdrawal of laba single-therapy inhaler in asthma [Comment]. The Lancet, 376(9743), 750-751. doi: 10.1016/S0140-6736(10)61158-0 Beasley, R., Weatherall, M., Travers, J., & Shirtcliffe, P. (2009). Time to define the disorders of the syndrome of COPD [Comment]. Lancet, 374(9691), 670-672. Beasley, R., Wijesinghe, M., & Weatherall, M. (2009). Potential risks of using LABAs with ICS therapy [Letter to the editor]. American Journal of Respiratory and Critical Care Medicine, 180(6), 581. Boland, P., & Moriarty, H. (2009). Cardiovascular disease risk profile tools and New Zealand: The best way forward? [Essay]. Journal of Primary Health Care, 1(4), 328-331. Holt, S., Helm, C., Corin, A., Williams, M., & Weatherall, M. (2009). A pilot study of the efficacy of a vitamin C-containing showerhead on symptoms of eczema [Letter]. New Zealand Medical Journal, 122(1300). Retrieved from http://www.nzma. org.nz/journal/archive.shtml Levack, W. M. M. (2009). Ethics in goal planning for rehabilitation: A utilitarian perspective. Clinical Rehabilitation, 23(4), 345-351. doi: 10.1177/0269215509103286 Weatherall, M., Shirtcliffe, P., Travers, J., & Beasley, R. (2010). Use of cluster analysis to define COPD phenotypes [Editorial]. European Respiratory Journal, 36(3), 472-474. doi: 10.1183/09031936.00035210 Weatherall, M., Travers, J., Shirtcliffe, P., Marsh, S., Williams, M., Nowitz, M., Aldington, S., & Beasley, R. (2010). Distinct clinical phenotypes of airways disease: A primary-care clinician perspective [Reply to letter to the editor]. European Respiratory Journal, 35(2), 459-460. doi: 10.1183/09031936.00167309

University of Otago Wellington Department of Obstetrics and Gynaecology

Chapter in Book - Research Maharaj, D. (2009). Complications of infections in pregnancy. In R. N. Canfield (Ed.), Infectious pregnancy complications (pp. 1-81). New York: Nova Science. Maharaj, D. (2009). Cross infections. In J. Dong & S. Liang (Eds.), Cross infections: Types, causes and prevention (pp. 1-35). New York: Nova Science.

Journal - Research Article Byard, R. W., & Zuccollo, J. M. (2010). Forensic issues in cases of water birth fatalities. American Journal of Forensic Medicine and Pathology, 31(3), 258-260. doi: 10.1097/PAF.0b013e3181e12eb8 Elder, D. E., Wong, A., & Zuccollo, J. M. (2009). Risk factors for and timing of death of extremely preterm infants. Australian and New Zealand Journal of Obstetrics and Gynaecology, 49(4), 407-410. doi: 10.1111/j.1479-828X.2009.01033.x Escott, A., Elder, D. E., & Zuccollo, J. M. (2009). Sudden unexpected infant death and bedsharing: Referrals to the Wellington Coroner 1997-2006. New Zealand Medical Journal, 122(1298). Retrieved from http://www.nzma.org.nz/ journal/122-1298/3686/ Keating, P., O’Sullivan, D., Tierney, J. B., Kenwright, D., Miromoeini, S., Mawasse, L., Brombacher, F., & La Flamme, A. C. (2009). Protection from EAE by IL-4Ra-/- macrophages depends upon T regulatory cell involvement. Immunology and Cell Biology, 87(7), 534-545. doi: 10.1038/icb.2009.37 Kidd, A., Wong, H. S., Zuccollo, J., Parker, S., Richardson, V., Tait, J., & Pringle, K. C. (2009). A case of amyoplasia in a monochorionic twin pregnancy: A sequela from twin-twin transfusion syndrome? Fetal Diagnosis and Therapy, 25(1), 31- 35. doi: 10.1159/000193224 Kitajima, K., Aoba, T., Pringle, K. C., Seki, Y., Zuccollo, J., et al. (2010). Bladder development following bladder outlet obstruction in fetal lambs: Optimal timing of fetal therapy. Journal of Pediatric Surgery, 45(12), 2423-2430. doi: 10.1016/j. jpedsurg.2010.08.047 Maharaj, D. (2009). Eating and drinking in labor: Should it be allowed? European Journal of Obstetrics, Gynecology, and Reproductive Biology, 146(1), 3-7. doi: 10.1016/j.ejogrb.2009.04.019

192 RESEARCH REPORT 2009/2010 Maharaj, D. (2009). Infectious complications in pregnancy. International Journal of Medical and Biological Frontiers, 15(7/8), 641-707. Maharaj, D., & Spronken-Smith, R. (2009). Seeking autonomy but craving direction: A qualitative study of registrars’ learning in obstetrics and gynecology. Focus on Health Professional Education, 10(3), 57-69. Wong, H. S., Cheung, Y. K., & Tait, J. (2009). Sonographic study of the decidua basalis in the first trimester of pregnancy. Ultrasound in Obstetrics and Gynecology, 33(6), 634-637. doi: 10.1002/uog.6311 Wong, H. S., Tait, J., & Pringle, K. C. (2009). Examination of the secondary palate on stored 3D ultrasound volumes of the fetal face. Ultrasound in Obstetrics and Gynecology, 33(4), 407-411. doi: 10.1002/uog.6339 Wong, H. S., Zuccollo, J., Tait, J., & Pringle, K. C. (2009). Placenta accreta in the first trimester of pregnancy: Sonographic findings [Case report]. Journal of Clinical Ultrasound, 37(2), 100-103. doi: 10.1002/jcu.20487

Journal - Research Other Broadmore, J., Hutton, J. D., & Langdana, F. (2009). Medical students’ experience of vaginal examinations of anaesthetised women [Short communication]. BJOG, 116(5), 731-733. doi: 10.1111/j.1471-0528.2008.02069.x Maharaj, D. (2010). Assessing cephalopelvic disproportion: Back to the basics. Obstetrical and Gynecological Survey, 65(6), 387-395. doi: 10.1097/OGX.0b013e3181ecdf0c Mitchell, E. A., Elder, D. E., & Zuccollo, J. (2010). Simultaneous sudden unexpected death in infancy of twins: Case report. International Journal of Legal Medicine, 124(6), 631-635. doi: 10.1007/s00414-009-0407-y

Commissioned Report for External Body Perinatal and Maternal Mortality Review Committee, including Elder, D., & Zuccollo, J. (2009). Perinatal and maternal mortality in New Zealand 2007: Third report to the Minister of Health: July 2008 to June 2009. Wellington, New Zealand: Perinatal and Maternal Mortality Review Committee, 68p. Perinatal and Maternal Mortality Review Committee, including Elder, D., & Zuccollo, J. (2009). Perinatal and maternal mortality in New Zealand 2006: Second report to the Minister of Health: July 2007 to June 2008. Wellington, New Zealand: Perinatal and Maternal Mortality Review Committee, 78p. Perinatal and Maternal Mortality Review Committee, including Elder, D., Zuccollo, J., & Lawton, B. (2010). Perinatal and maternal mortality in New Zealand 2008: Fourth report to the Minister of Health: July 2009 to June 2010. Wellington, New Zealand: Perinatal and Maternal Mortality Review Committee, 95p.

University of Otago Wellington Department of Paediatrics and Child Health

Journal - Research Article Bahmanyar, S., Ekbom, A., Askling, J., Johannesson, M., & Montgomery, S. M. (2010). Cystic fibrosis gene mutations and gastrointestinal diseases. Journal of Cystic Fibrosis, 9(4), 288-291. doi: 10.1016/j.jcf.2010.03.010 Bergin, P. S., Ip, T., Sheehan, R., Frith, R. W., Sadleir, L. G., McGrath, N., Ranta, A., & Walker, E. B. (2010). Using the Internet to recruit patients for epilepsy trials: Results of a New Zealand pilot study. Epilepsia, 51(5), 868-873. doi: 10.1111/j.1528- 1167.2009.02393.x Calvo, S. E., Tucker, E. J., Compton, A. G., ..., Wiltshire, E., et al. (2010). High-throughput, pooled sequencing identifies mutations in NUBPL and FOXRED1 in human complex I deficiency. Nature Genetics, 42(10), 851-858. doi: 10.1038/ ng.659 Carey, R., Healy, C., & Elder, D. E. (2010). Foreign body sexual assault complicated by rectovaginal fistula [Case report]. Journal of Forensic and Legal Medicine, 17(3), 161-163. doi: 10.1016/j.jflm.2009.09.009 Chandrahasen, C., Grimwood, K., Redshaw, N., Rich, F. J., Wood, C., Stanley, J., Kirman, J. R., & New Zealand Rotavirus Study Group (2010). Geographical differences in the proportion of human group A rotavirus strains within New Zealand during one epidemic season. Journal of Medical Virology, 82(5), 897-902. doi: 10.1002/jmv.21739 Dekker, J. W., Wickens, K., Black, P. C., Stanley, T. V., Mitchell, E. A., Fitzharris, P., Tannock, G. W., Purdie, G., & Crane, J. (2009). Safety aspects of probiotic bacterial strains Lactobacillus rhamnosus HN001 and Bifidobacterium animalis subsp. lactis HN019 in human infants aged 0-2 years. International Dairy Journal, 19(3), 149-154. doi: 10.1016/j. idairyj.2008.10.004 Elder, D. E., Campbell, A. J., Larsen, P. D., & Galletly, D. (2010). Respiratory variability in preterm and term infants: Effect of sleep state; position and age. Respiratory Physiology & Neurobiology, Advance Online Publication. doi: 10.1016/j. resp.2010.11.011 Elder, D. E., Larsen, P. D., Galletly, D. C., & Campbell, A. J. (2010). Cardioventilatory coupling in preterm and term infants: Effect of position and sleep state. Respiratory Physiology & Neurobiology, 174(1-2), 128-134. doi: 10.1016/j. resp.2010.05.012 Elder, D. E., Whale, J., Galletly, D., & Campbell, A. J. (2010). Respiratory events in preterm infants prior to discharge: With and without clinically concerning apnoea. Sleep and Breathing, Advance Online Publication. doi: 10.1007/s11325-010-0457-x Elder, D. E., Wong, A., & Zuccollo, J. M. (2009). Risk factors for and timing of death of extremely preterm infants. Australian and New Zealand Journal of Obstetrics and Gynaecology, 49(4), 407-410. doi: 10.1111/j.1479-828X.2009.01033.x

Division of HEALTH SCIENCES 193 Escott, A., Elder, D. E., & Zuccollo, J. M. (2009). Sudden unexpected infant death and bedsharing: Referrals to the Wellington Coroner 1997-2006. New Zealand Medical Journal, 122(1298). Retrieved from http://www.nzma.org.nz/ journal/122-1298/3686/ Kidd, A., Wong, H. S., Zuccollo, J., Parker, S., Richardson, V., Tait, J., & Pringle, K. C. (2009). A case of amyoplasia in a monochorionic twin pregnancy: A sequela from twin-twin transfusion syndrome? Fetal Diagnosis and Therapy, 25(1), 31- 35. doi: 10.1159/000193224 MacKenzie, K. E., Wiltshire, E. J., Peña, A. S., Gent, R., Hirte, C., Piotto, L., & Couper, J. J. (2009). Hs-CRP is associated with weight, BMI, and female sex but not with endothelial function in children with type 1 diabetes. Pediatric Diabetes, 10(1), 44-51. doi: 10.1111/j.1399-5448.2008.00456.x Newton, K., Wiltshire, E. J., & Elley, C. R. (2009). Pedometers and text messaging to increase physical activity: Randomized controlled trial of adolescents with type 1 diabetes. Diabetes Care, 32(5), 813-815. doi: 10.2337/dc08-1974 Nilsson, H. E., Dragomir, A., Lazorova, L., Johannesson, M., & Roomans, G. M. (2010). CFTR and tight junctions in cultured bronchial epithelial cells. Experimental and Molecular Pathology, 88(1), 118-127. doi: 10.1016/j.yexmp.2009.09.018 Olesen, H. V., Pressler, T., Hjelte, L., Mared, L., ..., Johannesson, M., & Scandinavian Cystic Fibrosis Study Consortium (2010). Gender differences in the Scandinavian Cystic Fibrosis population. Pediatric Pulmonology, 45(10), 959-965. doi: 10.1002/ ppul.21265 Oliynyk, I., Varelogianni, G., Roomans, G., & Johannesson, M. (2010). Effect of duramycin on chloride transport and intracellular calcium concentration in cystic fibrosis and non-cystic fibrosis epithelia. APMIS, 118(12), 982-990. doi: 10.1111/j.1600-0463.2010.02680.x Peña, A. S., Belobrajdic, D. P., Wiltshire, E., Gent, R., Hirte, C., & Couper, J. (2010). Adiponectin relates to smooth muscle function and folate in obese children. International Journal of Pediatric Obesity, 5(2), 185-191. doi: 10.3109/17477160903111748 Sadleir, L. G., & Scheffer, I. E. (2010). Optimizing electroencephalographic studies for epilepsy diagnosis in children with new- onset seizures. Archives of Neurology, Advance Online Publication. doi: 10.1001/archneurol.2010.155 Sadleir, L. G., Scheffer, I. E., Smith, S., Carstensen, B., Farrell, K., & Connolly, M. B. (2009). EEG features of absence seizures in idiopathic generalized epilepsy: Impact of syndrome, age, and state. Epilepsia, 50(6), 1572-1578. doi: 10.1111/j.1528- 1167.2008.02001.x Sadleir, L. G., Scheffer, I. E., Smith, S., Connolly, M. B., & Farrell, K. (2009). Automatisms in absence seizures in children with idiopathic generalized epilepsy. Archives of Neurology, 66(6), 729-734. doi: 10.1001/archneurol.2009.108 Tan, S. T., Itinteang, T., & Leadbitter, P. (2010). Low-dose propranolol for infantile haemangioma. Journal of Plastic, Reconstructive & Aesthetic Surgery, Advance Online Publication. doi: 10.1016/j.bjps.2010.06.010 Varelogianni, G., Oliynyk, I., Roomans, G. M., & Johannesson, M. (2010). The effect of N-acetylcysteine on chloride efflux from airway epithelial cells. Cell Biology International, 34(3), 245-252. doi: 10.1042/CBI20090007 Wicks, L., & Mitchell, A. (2010). The adolescent cancer experience: Loss of control and benefit finding. European Journal of Cancer Care, 19(6), 778-785. doi: 10.1111/j.1365-2354.2009.01139.x

Journal - Research Other Grimwood, K., Kidd, T. J., & Tweed, M. (2009). Successful treatment of cepacia syndrome [Letter to the editor]. Journal of Cystic Fibrosis, 8(4), 291-293. doi: 10.1016/j.jcf.2009.04.002 Mitchell, E. A., Elder, D. E., & Zuccollo, J. (2010). Simultaneous sudden unexpected death in infancy of twins: Case report. International Journal of Legal Medicine, 124(6), 631-635. doi: 10.1007/s00414-009-0407-y

Commissioned Report for External Body Perinatal and Maternal Mortality Review Committee, including Elder, D., & Zuccollo, J. (2009). Perinatal and maternal mortality in New Zealand 2006: Second report to the Minister of Health: July 2007 to June 2008. Wellington, New Zealand: Perinatal and Maternal Mortality Review Committee, 78p. Perinatal and Maternal Mortality Review Committee, including Elder, D., & Zuccollo, J. (2009). Perinatal and maternal mortality in New Zealand 2007: Third report to the Minister of Health: July 2008 to June 2009. Wellington, New Zealand: Perinatal and Maternal Mortality Review Committee, 68p. Perinatal and Maternal Mortality Review Committee, including Elder, D., Zuccollo, J., & Lawton, B. (2010). Perinatal and maternal mortality in New Zealand 2008: Fourth report to the Minister of Health: July 2009 to June 2010. Wellington, New Zealand: Perinatal and Maternal Mortality Review Committee, 95p.

Awarded PhD Thesis Elder, D. E. (2010). Respiratory variability in infants and children. Dunedin, New Zealand: University of Otago, 290p.

194 RESEARCH REPORT 2009/2010 University of Otago Wellington Department of Pathology and Molecular Medicine

Journal - Research Article Aydin, H., Chen, L., Cheng, L., Vaziri, A., He, H., Ganapathi, R., Delahunt, B., et al. (2010). Clear cell tubulopapillary renal cell carcinoma: A study of 36 distinctive low-grade epithelial tumors of the kidney. American Journal of Surgical Pathology, 34(11), 1608-1621. doi: 10.1097/PAS.0b013e3181f2ee0b Brennan, C., Srigley, J. R., Whelan, C., Cooper, J., & Delahunt, B. (2010). Type 2 and clear cell papillary renal cell carcinoma, and tubulocystic carcinoma: A unifying concept. Anticancer Research, 30(2), 641-644. Brunelli, M., Delahunt, B., Gobbo, S., Tardanico, R., Eccher, A., Bersani, S., et al. (2010). Diagnostic usefulness of fluorescent cytogenetics in differentiating chromophobe renal cell carcinoma from renal oncocytoma: A validation study combining metaphase and interphase analyses. American Journal of Clinical Pathology, 133(1), 116-126. doi: 10.1309/ajcpsatjtkbi6j4n Byard, R. W., & Zuccollo, J. M. (2010). Forensic issues in cases of water birth fatalities. American Journal of Forensic Medicine and Pathology, 31(3), 258-260. doi: 10.1097/PAF.0b013e3181e12eb8 Dalfior, D., Delahunt, B., Brunelli, M., Parisi, A., Ficarra, V., et al. (2010). Utility of racemase and other immunomarkers in the detection of adenocarcinoma in prostatic tissue damaged by high intensity focused ultrasound therapy. Pathology, 42(1), 1-5. doi: 10.3109/00313020903434447 Delahunt, B. (2009). Advances and controversies in grading and staging of renal cell carcinoma. Modern Pathology, 22(S2), S24-S36. doi: 10.1038/modpathol.2008.183 Delahunt, B., Lamb, D. S., Srigley, J. R., Murray, J. D., Wilcox, C., et al. (2010). Gleason scoring: A comparison of classical and modified (International Society of Urological Pathology) criteria using nadir PSA as a clinical end point. Pathology, 42(4), 339-343. doi: 10.3109/00313021003787924 Filoche, S. K., Cornford, E., Gaude, W., Wong, M., Heasman, P., & Thomson, W. M. (2010). Smoking, chronic periodontitis and smoking cessation support: Reviewing the role of dental professionals. New Zealand Dental Journal, 106(2), 74-77. Filoche, S., Wong, L., & Sissons, C. H. (2010). Oral biofilms: Emerging concepts in microbial ecology. Journal of Dental Research, 89(1), 8-18. doi: 10.1177/0022034509351812

Florkowski, C., & Crooke, M. (2010). Standardisation of reporting haemoglobin A1c: Adoption of the New Zealand Society for the Study of Diabetes (NZSSD) position statement. New Zealand Medical Journal, 1231310). Retrieved from http://www. nzma.org.nz/journal/archive.shtml Fontana, M., Catt, D., Eckert, G. J., ..., & Sissons, C. H. (2009). Xylitol: Effects on the acquisition of cariogenic species in infants. Pediatric Dentistry, 31(3), 257-266. Galvão, D. A., Spry, N., Taaffe, D. R., ..., Lamb, D. S., et al. (2009). A randomized controlled trial of an exercise intervention targeting cardiovascular and metabolic risk factors for prostate cancer patients from the RADAR trial. BMC Cancer, 9, 419. doi: 10.1186/1471-2407-9-419 Gobbo, S., Eble, J. N., Delahunt, B., Grignon, D. J., Samaratunga, H., Martignoni, G., et al. (2010). Renal cell neoplasms of oncocytosis have distinct morphologic, immunohistochemical, and cytogenetic profiles. American Journal of Surgical Pathology, Advance Online Publication. doi: 10.1097/PAS.0b013e3181d73293 Harvie, M., Camberis, M., Tang, S-C., Delahunt, B., Paul, W., & Le Gros, G. (2010). The lung is an important site for priming CD4 T cell mediated protective immunity against gastrointestinal helminth parasites. Infection and Immunity, Advance Online Publication. doi: 10.1128/IAI.00502-09 Jatrana, S., Crampton, P., & Filoche, S. (2009). The case for integrating oral health into primary health care. New Zealand Medical Journal, 122(1301). Retrieved from http://www.nzma.org.nz/journal/122-1301/3751/ Jovanovic, L., Delahunt, B., McIver, B., Eberhardt, N. L., Bhattacharya, A., et al. (2010). Distinct genetic changes characterise multifocality and diverse histological subtypes in papillary thyroid carcinoma. Pathology, 42(6), 524-533. doi: 10.3109/00313025.2010.508780 Kirana, C., Ward, T., Jordan, T. W., Rawson, P., Royds, J., Shi, H. J., Stubbs, R., & Hood, K. (2009). Compatibility of toluidine blue with laser microdissection and saturation labeling DIGE. Proteomics, 9(2), 485-490. doi: 10.1002/pmic.200800197 Lamb, D. S., Denham, J. W., Joseph, D., Matthews, J., ..., Delahunt, B., & D’Este, C. (2010). A comparison of the prognostic value of early PSA test-based variables following external beam radiotherapy, with or without preceding androgen deprivation: Analysis of data from the TROG 96.01 randomized trial. International Journal of Radiation Oncology, Biology, Physics, Advance Online Publication. doi: 10.1016/j.ijrobp.2009.10.071 Logan, T. P., Cutress, T. W., Garrett, N., & Trengrove, H. G. (2009). Dental status of New Zealand Defence Force personnel. New Zealand Dental Journal, 105(2), 38-42. Mahoney, E. K., & Morrison, D. G. (2009). The prevalence of Molar-Incisor Hypomineralisation (MIH) in Wainuiomata children. New Zealand Dental Journal, 105(4), 121-127. Mittal, A., Göke, F., Flint, R., Loveday, B. P. T., Thompson, N., Delahunt, B., et al. (2010). The redox status of experimental hemorrhagic shock as measured by cyclic voltammetry. Shock, 33(5), 460-466. doi: 10.1097/SHK.0b013e3181c0ea12 Mittal, A., Middleditch, M., Ruggiero, K., Loveday, B., Delahunt, B., et al. (2010). Changes in the mesenteric lymph proteome induced by haemorrhagic shock. Shock, 34(2), 140-149. doi: 10.1097/SHK.0b013e3181cd8631 Moch, H., Artibani, W., Delahunt, B., Ficarra, V., Knuechel, R., et al. (2009). Reassessing the current UICC/AJCC TNM staging for renal cell carcinoma. European Urology, 56(4), 636-643. doi: 10.1016/j.eururo.2009.06.036 Samaratunga, H., Duffy, D., Yaxley, J., & Delahunt, B. (2010). Any proportion of ductal adenocarcinoma in radical prostatectomy specimens predicts extraprostatic extension. Human Pathology, 41(2), 281-285. doi: 10.1016/j. humpath.2009.08.010

Division of HEALTH SCIENCES 195 Samaratunga, H., Samaratunga, D., Perry-Keene, J., Adamson, M., Yaxley, J., & Delahunt, B. (2010). Distal seminal vesicle invasion by prostate adenocarcinoma does not occur in isolation of proximal seminal vesicle invasion or lymphovascular infiltration. Pathology, 42(4), 330-333. doi: 10.3109/00313021003767330 Srigley, J. R., & Delahunt, B. (2009). Uncommon and recently described renal carcinomas. Modern Pathology, 22(S2), S2-S23. doi: 10.1038/modpathol.2009.70 van Loveren, C., Gerardu, V. A. M., Sissons, C. H., van Bekkum, M., & ten Cate, J. M. (2009). Effect of various rinsing protocols after use of amine fluoride/stannous fluoride toothpaste on the bacterial composition of dental plaque. Caries Research, 43(6), 462-467. doi: 10.1159/000264683 Wood, C., D’Souza, A., & Carter, J. M. (2010). A single centre review investigating whether the transport times of mud stem cells influences engraftment times post hsct. Biology of Blood and Marrow Transplantation, 16(2, Supplement 1), S285-S286. doi: 10.1016/j.bbmt.2009.12.388

Journal - Research Other Delahunt, B., Bethwaite, P. B., Miller, R. J., Sika-Paotonu, D., & Srigley, J. R. (2010). Re: Fuhrman grade provides higher prognostic accuracy than nucleolar grade for papillary renal cell carcinoma [Letter to the editor/errata]. The Journal of Urology, 185(1), 356-357. doi: 10.1016/j.juro.2010.08.045 Delahunt, B., Srigley, J. R., & Lamb, D. S. (2009). Gleason grading: Consensus and controversy [Editorial]. Pathology, 41(7), 613-614. doi: 10.3109/00313020903308823 Foo, J., Toomath, R., Wickremesekera, S. K., Bann, S., & Stubbs, R. (2010). Bariatric surgery: A dilemma for the health system? [Editorial]. New Zealand Medical Journal, 123(1311). Retrieved from http://www.nzmj.org/journal/123-1311/ Lamb, D. S., Delahunt, B., Denham, J., & Slaney, D. (2009). Survival benefit confirmed for prostate cancers diagnosed by PSA testing [Letter to the editor]. New Zealand Medical Journal, 122(1299). Retrieved from http://www.nzma.org.nz/ journal/122-1299/3704/ Tan, P. H., Cheng, L., Srigley, J. R., ..., Delahunt, B., et al. (2010). International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens: Working group 5: Surgical margins. Modern Pathology, 24(1), 48-57. doi: 10.1038/modpathol.2010.155 Teo, A., Hemmings, C., & Miller, R. (2010). Sarcomatoid localised mesothelioma mimicking intrapulmonary synovial sarcoma: A case report and review of the literature [Letter]. Pathology, 42(2), 182-184. doi: 10.3109/00313020903493971

Journal - Professional & Other Non-Research Articles Delahunt, B. (2009). A further step on the journey [Editorial]. Pathology, 41(2), 103-104.

University of Otago Wellington Department of Primary Health Care and General Practice

Authored Book - Research Moriarty, H., Stubbe, M., Bradford, S., & Tapper, S. (2010). Living with addiction: Exploring the issues for families [Blue Skies Report No. 35/10]. Wellington, New Zealand: Families Commission, 64p.

Chapter in Book - Research McKinlay, E., & McBain, L. (2010). The palliative care partnership: The evolution of a New Zealand model of integrated palliative care. In A. Fortier & S. Turcotte (Eds.), Health education: Challenges, issues and impact (pp. 241-262). New York: Nova.

Journal - Research Article Avery, A. J., Rodgers, S., ..., Morris, C. J., Murray, S. A., Prescott, R. J., Cresswell, K., & Sheikh, A. (2009). Protocol for the PINCER trial: A cluster randomised trial comparing the effectiveness of a pharmacist-led IT-based intervention with simple feedback in reducing rates of clinically important errors in medicines management in general practices. Trials, 10. doi: 10.1186/1745-6215-10-28 Ballantyne, A. J. (2010). How to do research fairly in an unjust world. American Journal of Bioethics, 10(6), 26-35. doi: 10.1080/15265161.2010.482629 Barthow, C., Moss, C., McKinlay, E., McCullough, L., & Wise, D. (2009). To be involved or not: Factors that influence nurses’ involvement in providing treatment decisional support in advanced cancer. European Journal of Oncology Nursing, 13(1), 22-28. doi: 10.1016/j.ejon.2008.09.004 Bupha-Intr, O., Rose, S. B., Lawton, B. A., Elley, C. R., & Dowell, A. C. (2010). Are at-risk New Zealand women receiving recommended cardiovascular preventive therapy? New Zealand Medical Journal, 123(1309). Retrieved from http://www. nzma.org.nz/journal/123-1309/ Chan, C., & Moriarty, H. (2010). A special type of ‘hard-to-reach’ patient: Experiences of pregnant women on methadone. Journal of Primary Health Care, 2(1), 61-69. Dew, K., Stubbe, M., MacDonald, L., Dowell, A., & Plumridge, E. (2010). The (non) use of prioritisation protocols by surgeons. Sociology of Health and Illness, 32(4), 545-562. doi: 10.1111/j.1467-9566.2009.01229.x

196 RESEARCH REPORT 2009/2010 Handley, J., Pullon, S., & Gifford, H. (2010). Living with type 2 diabetes: ‘Putting the person in the pilots’ seat’. Australian Journal of Advanced Nursing, 27(3), 12-19. Hegarty, K., Gunn, J., Blashki, G., Griffiths, F., Dowell, T., & Kendrick, T. (2009). How could depression guidelines be made more relevant and applicable to primary care? A quantitative and qualitative review of national guidelines. British Journal of General Practice, 59(562), 322-328. doi: 10.3399/bjgp09X420581 Judson, G., Bird, R., O’Connor, P., ..., Weatherall, M., Moriarty, H., & Robinson, G. (2010). Drug injecting in patients in New Zealand Methadone Maintenance Treatment programs: An anonymous survey. Drug and Alcohol Review, 29(1), 41-46. doi: 10.1111/j.1465-3362.2009.00080.x Kerse, N., Hayman, K. J., Moyes, S. A., Peri, K., Robinson, E., Dowell, A., ..., Keeling, S., et al. (2010). Home-based activity program for older people with depressive symptoms: DeLLITE-a randomized controlled trial. Annals of Family Medicine, 8(3), 214-223. doi: 10.1370/afm.1093 Lawton, B. A., Rose, S. B., Elley, C. R., Bromhead, C., MacDonald, E. J., & Baker, M. G. (2010). Increasing the uptake of opportunistic chlamydia screening: A pilot study in general practice. Journal of Primary Health Care, 2(3), 199-207. Lawton, B. A., Rose, S. B., Elley, C. R., Dowell, A. C., Fenton, A., & Moyes, S. A. (2009). Exercise on prescription for women aged 40-74 recruited through primary care: Two year randomised controlled trial. British Journal of Sports Medicine, 43(2), 120-123. Lawton, B. A., Wilson, L. F., Dinsdale, R. A., Rose, S. B., Brown, S. A., Tait, J., et al. (2010). Audit of severe acute maternal morbidity describing reasons for transfer and potential preventability of admissions to ICU. Australian and New Zealand Journal of Obstetrics and Gynaecology, 50(4), 346-351. doi: 10.1111/j.1479-828X.2010.01200.x McCullough, L., McKinlay, E., Barthow, C., Moss, C., & Wise, D. (2010). A model of treatment decision making when patients have advanced cancer: How do cancer treatment doctors and nurses contribute to the process? European Journal of Cancer Care, 19(4), 482-491. doi: 10.1111/j.1365-2354.2009.01074.x McKinlay, E., Kljakovic, M., & McBain, L. (2009). New Zealand men’s health care: Are we meeting the needs of men in general practice? Journal of Primary Health Care, 1(4), 302-310. McKinlay, E., McBain, L., & Gray, B. (2009). Teaching and learning about chronic conditions management for undergraduate medical students: Utilizing the patient-as-teacher approach. Chronic Illness, 5(3), 209-218. doi: 10.1177/1742395309343812 Phillips, C. B., Pearce, C. M., Hall, S., Travaglia, J., de Lusignan, S., Love, T., & Kljakovic, M. (2010). Can clinical governance deliver quality improvement in Australian general practice and primary care? A systematic review of the evidence. Medical Journal of Australia, 193(10), 602-607. Poole, P. J., Moriarty, H. J., Wearn, A. M., Wilkinson, T. J., & Weller, J. M. (2009). Medical student selection in New Zealand: Looking to the future. New Zealand Medical Journal, 122(1306). Retrieved from http://www.nzma.org.nz/ journal/122-1306/3884/ Pullon, S., McKinlay, E., & Dew, K. (2009). Primary health care in New Zealand: The impact of organisational factors on teamwork. British Journal of General Practice, 59(560), 191-197. Rogers, W., & Ballantyne, A. (2010). Towards a practical definition of professional behaviour. Journal of Medical Ethics, 36(4), 250-254. doi: 10.1136/jme.2009.035121 Rose, S. B., Lawton, B. A., Bromhead, C., MacDonald, E. J., & Elley, C. R. (2010). Poor uptake of self-sample collection kits for chlamydia testing outside primary care. Australian and New Zealand Journal of Public Health, 34(5), 517-520. doi: 10.1111/j.1753-6405.2010.00600.x Rose, S. B., Lawton, B. A., & Brown, S. A. (2010). Uptake and adherence to long-acting reversible contraception post-abortion. Contraception, 82, 345-353. doi: 10.1016/j.contraception.2010.04.021 Rose, S. B., Lawton, B. A., Lanumata, T., Hibma, M., & Baker, M. G. (2010). HPV/cervical cancer vaccination: Parental preferences on age, place and information needs. Journal of Primary Health Care, 2(3), 190-198. Willmot, E-J., Lawton, B. A., Rose, S. B., & Brown, S. (2009). Exploring knowledge of prescription charges: A cross-sectional survey of pharmacists and the community. New Zealand Medical Journal, 122(1301). Retrieved from http://www.nzma. org.nz/journal/122-1301/3753/ Wilson, N., Peace, J., Li, J., Edwards, R., Hoek, J., Stanley, J., & Thomson, G. (2009). Distribution of new graphic warning labels: Are tobacco companies following regulations? Tobacco Induced Diseases, 5(1), 14. doi: 10.1186/1617-9625-5-14

Journal - Research Other Ballantyne, A. J. (2010). Reponse to open peer commentaries on ²How to do research fairly in an unjust world². American Journal of Bioethics, 10(6), W4-W6. doi: 10.1080/15265161.2010.492747 Ballantyne, A., & Rogers, W. (2010). Gender agenda: Let’s track women’s trial participation [Letter]. Nature, 465(7301), 1005. doi: 10.1038/4651005d Boland, P., & Moriarty, H. (2009). Cardiovascular disease risk profile tools and New Zealand: The best way forward? [Essay]. Journal of Primary Health Care, 1(4), 328-331. Broadmore, J., Hutton, J. D., & Langdana, F. (2009). Medical students’ experience of vaginal examinations of anaesthetised women [Short communication]. BJOG, 116(5), 731-733. doi: 10.1111/j.1471-0528.2008.02069.x Dew, K., Stubbe, M., MacDonald, L., Dowell, A., & Plumridge, E. (2010). How useful are clinical priority assessment tools? [Research Gems]. Journal of Primary Health Care, 2(2), 174-175.

Division of HEALTH SCIENCES 197 Gray, B. (2009). The workforce shortage disadvantages those in greatest need [Guest editorial]. Journal of Primary Health Care, 1(2), 99-100. Gray, B. (2010). [Review of the book Interpreting in New Zealand: The pathway forward]. New Zealand Medical Journal, 123(1310). Retrieved from http://www.nzma.org.nz/journal/123-1310/4020/content.pdf Mathieson, F., Collings, S., & Dowell, A. (2009). Sub-threshold mental health syndromes: Finding an alternative to the medication of unhappiness [Essay]. Journal of Primary Health Care, 1(1), 74-77. Moriarty, H. J., Flewett, T. P., & Hyslop, B. A. (2009). Does alcohol play a role in QT prolongation? [Letter to the editor]. Internal Medicine Journal, 39(9), 631-632. doi: 10.1111/j.1445-5994.2009.01964.x Pullon, S., & McBain, L. (2009). Out-of-hours care: Renumeration alone is no panacea [Editorial]. British Journal of General Practice, 59(558), 3-4. doi: 10.3399/bjgp09X394770 Pullon, S., & McKinlay, E. (2009). Primary care workforce planning: What’s happened to the ‘Logan’ report? [Guest editorial]. Journal of Primary Health Care, 1(2), 92-93. Rodenburg, H., Dowell, T., & James, K. (2009). Primary mental health care: Service delivery and the impact on the workforce [Guest editorial]. Journal of Primary Health Care, 1(2), 94-95.

Journal - Professional & Other Non-Research Articles McKinlay, E., McBain, L., & Gray, B. (2009). Teaching chronic condition management to undergraduate medical students: Utilising the patient-as-teacher approach [Letter to the editor]. Medical Teacher, 31(9), 870. Moriarty, H., & Boswell, R. (2009). Status of EHR in New Zealand. RACP News, (February), 11. Pullon, S. (2010). Interprofessional education: Training for teamwork. GP Pulse, (December), 14-16. Stubbe, M. (2009). [Review of the book Variational pragmatics: A focus on regional varieties in pluricentric languages]. Journal of Politeness Research-Language Behaviour Culture, 5(2), 317-323. doi: 10.1515/JPLR.2009.015

Commissioned Report for External Body Dowell, A. C., Garrett, S., Collings, S., McBain, L., McKinlay, E., & Stanley, J. (2009). Evaluation of the Primary Mental Health Initiatives: Summary report. Wellington, New Zealand: University of Otago and the Ministry of Health, 80p. Moriarty, H., Stubbe, M., & Bradford, S. (2009). Opportunities for alcohol and other drug advice in the GP consultation. Commissioned by National Drug Policy New Zealand. Wellington, New Zealand: University of Otago, 71p. Perinatal and Maternal Mortality Review Committee, including Elder, D., Zuccollo, J., & Lawton, B. (2010). Perinatal and maternal mortality in New Zealand 2008: Fourth report to the Minister of Health: July 2009 to June 2010. Wellington, New Zealand: Perinatal and Maternal Mortality Review Committee, 95p. Stubbe, M., Hilder, J., & Hill, N. (2010). MCNZ evaluation of regular practice review consultation on proposed survey. Wellington, New Zealand: Department of Primary Health Care and General Practice, University of Otago, 51p.

Working Paper; Discussion Paper; Technical Report Perera, R., Morris, C., & Dowell, T. (2010). Voyage to quality: Clinical indicator report. Royal New Zealand College of General Practitioners. Wellington, New Zealand: Primary Health Care Quality Research Unit, University of Otago. (pp. 1-165). Perera, R., Morris, C., & Dowell, T. (2010). Voyage to quality: Clinical indicator report [Interim Report No. 6]. Royal New Zealand College of General Practitioners. Wellington, New Zealand: Primary Health Care Quality Research Unit, University of Otago. (pp. 1-54). Perera, R., Morris, C., & Dowell, T. (2010). Voyage to quality: Quality framework report [Interim report]. Royal New Zealand College of General Practitioners. Wellington, New Zealand: Primary Health Care Quality Research Unit, University of Otago. (pp. 1-19). Perera, R., Morris, C., & Dowell, T. (2010). Voyage to quality: Summary of work (February 2009-August 2010). Royal New Zealand College of General Practitioners. Wellington, New Zealand: Primary Health Care Quality Research Unit, University of Otago. (pp. 1-39). Perera, R., Morris, C., Laidlaw, T., Litchfield, M., Du Jary, S., & Dowell, T. (2009). Voyage to quality: Mapping the quality landscape [Interim report]. Royal New Zealand College of General Practitioners. Wellington, New Zealand: Primary Health Care Quality Research Unit, University of Otago. (pp. 1-118).

Ministry of Health Services Standard Goyal, S., Buddendijk, J., Dunlop, J. . . . Moriarty, H., et al. (2010). New Zealand Standard: Health and Disability Services Pharmacy Services Standard. Standards New Zealand. Wellington, New Zealand. [NZS 8134.7:2010].

Awarded PhD Thesis Stubbe, M. (2010). ²Was that my misunderstanding?²: Managing miscommunication and problematic talk at work. Wellington, New Zealand: Victoria University of Wellington, 246p.

198 RESEARCH REPORT 2009/2010 University of Otago Wellington Department of Psychological Medicine

Edited Book - Research Von Korff, M. R., Scott, K. M., & Gureje, O. (Eds.). (2009). Global perspectives on mental-physical comorbidity in the WHO World Mental Health Surveys. New York: Cambridge University Press, 322p.

Chapter in Book - Research Bell, E. M., Langdon, R., Siegert, R. J., & Ellis, P. M. (2010). The assessment of theory of mind in schizophrenia. In G. Dimaggio & P. H. Lysaker (Eds.), Metacognition and severe adult mental disorders: From research to treatment (pp. 115-133). Hove, UK: Routledge. Scott, K. M. (2009). Psychosocial predictors of adult-onset asthma. In M. R. Von Korff, K. M. Scott & O. Gureje (Eds.), Global perspectives on mental-physical comorbidity in the WHO World Mental Health Surveys (pp. 108-119). New York: Cambridge University Press. Scott, K. M. (2009). The association of age with depressive and anxiety disorders, by physical comorbidity status. In M. R. Von Korff, K. M. Scott & O. Gureje (Eds.), Global perspectives on mental-physical comorbidity in the WHO World Mental Health Surveys (pp. 84-94). New York: Cambridge University Press. Scott, K. M. (2009). The development of mental-physical comorbidity. In M. R. Von Korff, K. M. Scott & O. Gureje (Eds.), Global perspectives on mental-physical comorbidity in the WHO World Mental Health Surveys (pp. 97-107). New York: Cambridge University Press. Scott, K. M. (2009). The joint association of mental and physical conditions with disability. In M. R. Von Korff, K. M. Scott & O. Gureje (Eds.), Global perspectives on mental-physical comorbidity in the WHO World Mental Health Surveys (pp. 230- 238). New York: Cambridge University Press. Stein, D. J., Scott, K. M., & Von Korff, M. R. (2009). Early child adversity and later hypertension. In M. R. Von Korff, K. M. Scott & O. Gureje (Eds.), Global perspectives on mental-physical comorbidity in the WHO World Mental Health Surveys (pp. 128-135). New York: Cambridge University Press.

Journal - Research Article Berentson-Shaw, J., Scott, K., & Jose, P. E. (2009). Do self-efficacy beliefs predict the primiparous labour and birth experience? A longitudinal study. Journal of Reproductive and Infant Psychology, 27(4), 357-373. doi: 10.1080/02646830903190888 Bruffaerts, R., ..., Scott, K., Tsang, A., Vassilev, S. M., Williams, D. R., & Nock, M. K. (2010). Childhood adversities as risk factors for onset and persistence of suicidal behaviour. British Journal of Psychiatry, 197(1), 20-27. doi: 10.1192/bjp. bp.109.074716 Dronsfield, A. T., & Ellis, P. M. (2010). The medicinal history of phosphorus. Education in Chemistry, 47(5), 150-152. Dronsfield, A., Toon, R., & Ellis, P. (2010). Look who discovered caesium. Education in Chemistry, 47(4), 119-122. MacDonald, J., Sohn, S., & Ellis, P. (2010). Privacy, professionalism and Facebook: A dilemma for young doctors. Medical Education, 44(8), 805-813. doi: 10.1111/j.1365-2923.2010.03720.x Mathieson, F., Barnfield, T., & Young, G. (2009). What gets in the way of clinical contact? Student perceptions of barriers to patient contact. New Zealand Medical Journal, 122(1292). Retrieved from http://www.nzma.org.nz/journal/ Mathieson, F. M., Barnfield, T., & Beaumont, G. (2009). Are we as good as we think we are? Self-assessment versus other forms of assessment of competence in psychotherapy. Cognitive Behaviour Therapist, 2, 43-50. doi: 10.1017/S1754470X08000081 Oakley Browne, M. A., Wells, J. E., Scott, K. M., McGee, M. A., & New Zealand Mental Health Survey Research Team (2010). The Kessler Psychological Distress Scale in Te Rau Hinengaro: The New Zealand Mental Health Survey. Australian and New Zealand Journal of Psychiatry, 44(4), 314-322. doi: 10.3109/00048670903279820 Romans, S. (2010). Sexuality in women with schizophrenia. Current Women’s Health Reviews, 6(1), 3-11. doi: 10.2174/157340410790979743 Scott, K. M., & Collings, S. C. D. (2010). Gender and the association between mental disorders and disability. Journal of Affective Disorders, 125, 207-212. doi: 10.1016/j.jad.2010.06.022 Scott, K. M., Hwang, I., Chiu, W-T., Kessler, R. C., Sampson, N. A., et al. (2010). Chronic physical conditions and their association with first onset of suicidal behavior in the World Mental Health Surveys. Psychosomatic Medicine, 72, 712-719. doi: 10.1097/PSY.0b013e3181e3333d Scott, K. M., Oakley Browne, M. A., & Wells, J. E. (2010). Prevalence, impairment and severity of 12-month DSM-IV major depressive episodes in Te Rau Hinengaro: New Zealand Mental Health Survey 2003/4. Australian and New Zealand Journal of Psychiatry, 44(8), 750-758. doi: 10.3109/00048671003781780 Scott, K. M., Smith, D. R., & Ellis, P. M. (2010). Prospectively ascertained child maltreatment and its association with DSM-IV mental disorders in young adults. Archives of General Psychiatry, 67(7), 712-719. Scott, K. M., Von Korff, M., Alonso, J., Angermeyer, M. C., Bromet, E., Fayyad, J., et al. (2009). Mental-physical co-morbidity and its relationship with disability: Results from the World Mental Health Surveys. Psychological Medicine, 39(1), 33-43. doi: 10.1017/S0033291708003188 Scott, K. M., Wells, J. E., Angermeyer, M., Brugha, T. S., Bromet, E., Demyttenaere, K., de Girolamo, G., et al. (2010). Gender and the relationship between marital status and first onset of mood, anxiety and substance use disorders. Psychological Medicine, 40, 1495-1505. doi: 10.1017/S0033291709991942

Division of HEALTH SCIENCES 199 Seedat, S., Scott, K. M., Angermeyer, M. C., Berglund, P., Bromet, E. J., Brugha, T. S., et al. (2009). Cross-national associations between gender and mental disorders in the World Health Organization World Mental Health Surveys. Archives of General Psychiatry, 66(7), 785-795. Von Korff, M., Alonso, J., Ormel, J., Angermeyer, M., ..., Scott, K. M., & Uda, H. (2009). Childhood psychosocial stressors and adult onset arthritis: Broad spectrum risk factors and allostatic load. Pain, 143(1-2), 76-83. doi: 10.1016/j.pain.2009.01.034 Wells, J. E., Degenhardt, L., Bohnert, K. M., Anthony, J. C., Scott, K. M., & New Zealand Mental Health Survey Research Team (2009). Geographical clustering of cannabis use: Results from the New Zealand Mental Health Survey 2003-2004. Drug and Alcohol Dependence, 99(1-3), 309-316. doi: 10.1016/j.drugalcdep.2008.09.002 Wells, J. E., McGee, M. A., Scott, K. M., & Oakley-Browne, M. A. (2010). Bipolar disorder with frequent mood episodes in the New Zealand Mental Health Survey. Journal of Affective Disorders, 126(1-2), 65-74. doi: 10.1016/j.jad.2010.02.136

Journal - Research Other Dronsfield, A., & Ellis, P. (2009). Epilepsy: Beyond bromide. Education in Chemistry, 46(3), 85-88. Dronsfield, A., & Ellis, P. (2009). Phosphorus: Food for thought. Education in Chemistry, 46(6). Retrieved from http://www.rsc. org/Education/EiC/issues/index.asp Dronsfield, A., & Ellis, P. (2009). Solving an infectious problem. Education in Chemistry, 46(5), 153-156. Huthwaite, M. A., & Stanley, J. (2010). Lithium in drinking water [Correspondence]. British Journal of Psychiatry, 196(2), 159. doi: 10.1192/bjp.196.2.159 Mathieson, F., Collings, S., & Dowell, A. (2009). Sub-threshold mental health syndromes: Finding an alternative to the medication of unhappiness [Essay]. Journal of Primary Health Care, 1(1), 74-77. Moriarty, H. J., Flewett, T. P., & Hyslop, B. A. (2009). Does alcohol play a role in QT prolongation? [Letter to the editor]. Internal Medicine Journal, 39(9), 631-632. doi: 10.1111/j.1445-5994.2009.01964.x Von Korff, M., & Scott, K. M. (2009). The authors’ response to Childhood psychosocial stressors and adult onset arthritis: A comment on Von Korff et al [Letter to the editor]. Pain, 144(3), 340-341. doi: 10.1016/j.pain.2009.04.024

University of Otago Wellington Department of Public Health

Authored Book - Research Analitis, A., Becker, P., Biggeri, A., Bouchama, A., De’Donato, F., D’Ippoliti, D., ..., Hales, S., et al. (2009). Improving public health responses to extreme weather/heat-waves: EuroHEAT. Copenhagen, Denmark: World Health Organization, 60p.

Edited Book - Research Howden-Chapman, P., Bennett, J., & Siebers, R. (Eds.). (2009). Do damp and mould matter? Health impacts of leaky homes. Wellington, New Zealand: Steele Roberts, 172p.

Edited Book - Other Signal, L., Egan, R., & Cook, L. (Eds.). (2009). Reviews of health promotion practice in Aotearoa New Zealand 2007-2008. Auckland, New Zealand: Health Promotion Forum of New Zealand & Health Promotion and Policy Unit, University of Otago, 138p.

Chapter in Book - Research Howden-Chapman, P., & Bennett, J. (2009). Why indoor dampness and mould matter. In P. Howden-Chapman, J. Bennett & R. Siebers (Eds.), Do damp and mould matter? Health impacts of leaky homes (pp. 7-18). Wellington, New Zealand: Steele Roberts. Walton, M., & Signal, L. (2010). Childhood obesity and the food environment. In J. Pearce & K. Witten (Eds.), Geographies of obesity: Environmental understandings of the obesity epidemic (pp. 111). Farnham, UK: Ashgate. Wilson, N., Howden-Chapman, P., Wickens, K., & Crane, J. (2009). Indoor mould exposure and health. In P. Howden- Chapman, J. Bennett & R. Siebers (Eds.), Do damp and mould matter? Health impacts of leaky homes (pp. 19-23). Wellington, New Zealand: Steele Roberts.

Journal - Research Article Aiello, A. E., Coulborn, R. M., Aragon, T. G., Baker, M. G., Burrus, B. B., Cowling, B., Duncan, A., ..., Priest, P., et al. (2010). Research findings from nonpharmaceutical intervention studies for pandemic influenza and current gaps in the research. American Journal of Infection Control, 38(4), 251-258. doi: 10.1016/j.ajic.2009.12.007 Alexander, H., Irwin, C., Purdie, G., & Hunn, M. (2010). Incidence and management of high grade glioma in Mäori and non- Mäori patients. Journal of Clinical Neuroscience, 17(9), 1144-1147. doi: 10.1016/j.jocn.2010.01.033 Andrés, A. R., Collings, S., & Qin, P. (2010). Sex-specific impact of socio-economic factors on suicide risk: A population-based case-control study in Denmark. European Journal of Public Health, 20(3), 265-270. doi: 10.1093/eurpub/ckp183 Baker, M. G., Easther, S., & Wilson, N. (2010). A surveillance sector review applied to infectious diseases at a country level. BMC Public Health, 10(332). doi: 10.1186/1471-2458-10-332

200 RESEARCH REPORT 2009/2010 Baker, M. G., Wilson, N., Huang, Q. S., Paine, S., Lopez, L., et al. (2009). Pandemic influenza A(H1N1)v in New Zealand: The experience from April to August 2009. Eurosurveillance, 14(34). Retrieved from http://www.eurosurveillance.org/ ViewArticle.aspx?ArticleId=19319 Baker, M., Thornley, C. N., Mills, C., Roberts, S., Perera, S., Peters, J., Kelso, A., Barr, I., & Wilson, N. (2010). Transmission of pandemic A/H1N1 2009 influenza on passenger aircraft: Retrospective cohort study. BMJ, 340, c2424. doi: 10.1136/bmj. c2424 Bandaranayake, D. R., Huang, Q. S., Bissielo, A., ..., Baker, M. G., et al. (2010). Risk factors and immunity in a nationally representative population following the 2009 influenza A(H1N1) pandemic. PLoS ONE, 5(10), e13211. doi: 10.1371/ journal.pone.0013211 Blakely, T., Carter, K., Wilson, N., Edwards, R., Woodward, A., Thomson, G., & Sarfati, D. (2010). If nobody smoked tobacco in New Zealand from 2020 onwards, what effect would this have on ethnic inequalities in life expectancy? New Zealand Medical Journal, 123(1320). Retrieved from http://www.nzmj.org/journal/archive.php Blakely, T., & McLeod, M. (2009). Will the financial crisis get under the skin and affect our health? Learning from the past to predict the future. New Zealand Medical Journal, 122(1307). Retrieved from http://www.nzma.org.nz/ journal/122-1307/3915/ Blakely, T., Richardson, K., Young, J., Callister, P., & Didham, R. (2009). Does mortality vary between Pacific groups in New Zealand? Estimating Samoan, Cook Island Mäori, Tongan, and Niuean mortality rates using hierarchical Bayesian modelling. New Zealand Medical Journal, 122(1307). Retrieved from http://www.nzma.org.nz/journal/archive.shtml Blakely, T., Richardson, K., Young, J., Graham, P., Tobias, M., Callister, P., Didham, R., & Atkinson, J. (2009). Does mortality vary between Pacific groups? Estimating Samoan, Cook Island Mäori, Tongan and Niuean mortality rates using hierarchical Bayesian modelling. Official Statistics Research Series, 5. Retrieved from http://www.statisphere.govt.nz/ official-statistics-research.aspx Borland, R., Wilson, N., Fong, G. T., Hammond, D., Cummings, K. M., Yong, H-H., Hosking, W., Hastings, G., et al. (2009). Impact of graphic and text warnings on cigarette packs: Findings from four countries over five years. Tobacco Control, 18(5), 358-364. doi: 10.1136/tc.2008.028043 Borland, R., Yong, H-H., Wilson, N., Fong, G. T., Hammond, D., Cummings, K. M., Hosking, W., & McNeill, A. (2009). How reactions to cigarette packet health warnings influence quitting: Findings from the ITC Four-Country survey. Addiction, 104(4), 669-675. doi: 10.1111/j.1360-0443.2009.02508.x Britton, E., Hales, S., Venugopal, K., & Baker, M. G. (2010). Positive association between ambient temperature and salmonellosis notifications in New Zealand, 1965-2006. Australian and New Zealand Journal of Public Health, 34(2), 126- 129. doi: 10.1111/j.1753-6405.2010.00495.x Britton, E., Hales, S., Venugopal, K., & Baker, M. G. (2010). The impact of climate variability and change on cryptosporidiosis and giardiasis rates in New Zealand. Journal of Water and Health, 8(3), 561-571. doi: 10.2166/wh.2010.049 Carroll, P., Casswell, S., Huakau, J., Perry, P., & Howden-Chapman, P. (2009). Environmental attitudes, beliefs about social justice and intention to vote green: Lessons for the New Zealand Green Party? Environmental Politics, 18(2), 257-278. doi: 10.1080/09644010802682635 Carter, K., Barber, P. A., & Shaw, C. (2010). How does self-reported history of stroke compare to hospitalization data in a population-based survey in New Zealand? Stroke, 41, 2678-2680. doi: 10.1161/STROKEAHA.110.598268 Carter, K. N., Blakely, T., Collings, S., Gunasekara, F. I., & Richardson, K. (2009). What is the association between wealth and mental health? Journal of Epidemiology and Community Health, 63(3), 221-226. doi: 10.1136/jech.2008.079483 Carter, K. N., Blakely, T., & Soeberg, M. (2010). Trends in survival and life expectancy by ethnicity, income and smoking in New Zealand: 1980s to 2000s. New Zealand Medical Journal, 123(1320). Retrieved from http://www.nzma.org.nz/journal/ archive.php Carter, K. N., Cronin, M., Blakely, T., Hayward, M., & Richardson, K. (2009). Cohort profile: Survey of Families, Income and Employment (SoFIE) and health extension (SoFIE-health). International Journal of Epidemiology, 39, 653-659. doi: 10.1093/ije/dyp215 Carter, K. N., Hayward, M., Blakely, T., & Shaw, C. (2009). How much and for whom does self-identified ethnicity change over time in New Zealand? Results from a longitudinal study. Social Policy Journal of New Zealand, 36, 32-45. Carter, K. N., Lanumata, T., Kruse, K., & Gorton, D. (2010). What are the determinants of food insecurity in New Zealand and does this differ for males and females? Australian and New Zealand Journal of Public Health, 34(6), 602-608. doi: 10.1111/j.1753-6405.2010.00615.x Carter, K., Shaw, C., Blakely, T., & Hayward, M. (2010). Understanding the determinants of consent for linkage of administrative health data with a longitudinal survey. Kōtuitui: New Zealand Journal of Social Sciences Online, 5(2), 53-60. doi: 10.1080/1177083X.2010.516440 Chandrahasen, C., Grimwood, K., Redshaw, N., Rich, F. J., Wood, C., Stanley, J., Kirman, J. R., & New Zealand Rotavirus Study Group (2010). Geographical differences in the proportion of human group A rotavirus strains within New Zealand during one epidemic season. Journal of Medical Virology, 82(5), 897-902. doi: 10.1002/jmv.21739 Chapman, R., Howden-Chapman, P., Viggers, H., O’Dea, D., & Kennedy, M. (2009). Retrofitting houses with insulation: A cost-benefit analysis of a randomised community trial. Journal of Epidemiology and Community Health, 63(4), 271-277. doi: 10.1136/jech.2007.070037 Chauhan, U., Baker, D., Edwards, R., & Hann, M. (2010). Improving care in cardiac rehabilitation for minority ethnic populations. European Journal of Cardiovascular Nursing, Advance Online Publication. doi: 10.1016/j.ejcnurse.2010.03.004

Division of HEALTH SCIENCES 201 Chauhan, U., Baker, D., Lester, H., & Edwards, R. (2010). Exploring uptake of cardiac rehabilitation in a minority ethnic population in England: A qualitative study. European Journal of Cardiovascular Nursing, 9(1), 68-74. doi: 10.1016/j. ejcnurse.2009.10.003 Collings, S. C., Ivory, V., Blakely, T., & Atkinson, J. (2009). Are neighbourhood social fragmentation and suicide associated in New Zealand? A national multilevel cohort study. Journal of Epidemiology and Community Health, 63(12), 1035-1042. doi: 10.1136/jech.2009.090985 Collings, S., & Kemp, C. G. (2010). Death knocks, professional practice, and the public good: The media experience of suicide reporting in New Zealand. Social Science and Medicine, 71, 244-248. doi: 10.1016/j.socscimed.2010.03.017 Cormack, D., Sarfati, D., Harris, R., Robson, B., Shaw, C., & Blakely, T. (2010). Re: ‘An overview of cancer and beliefs about the disease in indigenous people of Australia, Canada, New Zealand and the US’ [Letter]. Australian and New Zealand Journal of Public Health, 34(1), 90-91. doi: 10.1111/j.1753-6405.2010.00481.x Cunningham, R., Carter, K., Connor, J., & Fawcett, J. (2010). Does health status matter for the risk of injury? New Zealand Medical Journal, 123(1327). Retrieved from http://www.nzma.org.nz/journal/123-1327/4479/ Cunningham, R., Sarfati, D., Hill, S., Dennett, E., & O’Donnell, A. (2009). Colon cancer management in New Zealand: 1996- 2003. New Zealand Medical Journal, 122(1294). Retrieved from http://www.nzma.org.nz/journal/122-1294/3581/ Cunningham, R., Shaw, C., Blakely, T., Atkinson, J., & Sarfati, D. (2010). Ethnic and socioeconomic trends in breast cancer incidence in New Zealand. BMC Cancer, 10, 674. doi: 10.1186/1471-2407-10-674 Curtis, E., Harwood, M., Riddell, T., Robson, B., Harris, R., Mills, C., & Reid, P. (2010). Access and society as determinants of Ischaemic Heart Disease in indigenous populations. Heart, Lung and Circulation, 19, 316-324. doi: 10.1016/j. hlc.2010.04.129 Dare, A., Fancourt, N., Robinson, E., Wilkinson, T., & Bagg, W. (2009). Training the intern: The value of a pre-intern year in preparing students for practice. Medical Teacher, 31(8), e345-e350. doi: 10.1080/01421590903127669 Debski, S., Buckley, S., & Russell, M. (2009). Just who do we think children are? New Zealanders’ attitudes about children, childhood and parenting: An analysis of submissions on the Bill to repeal section 59 of the Crimes Act 1961. Social Policy Journal of New Zealand, 34, 100-112. Dekker, J. W., Wickens, K., Black, P. C., Stanley, T. V., Mitchell, E. A., Fitzharris, P., Tannock, G. W., Purdie, G., & Crane, J. (2009). Safety aspects of probiotic bacterial strains Lactobacillus rhamnosus HN001 and Bifidobacterium animalis subsp. lactis HN019 in human infants aged 0-2 years. International Dairy Journal, 19(3), 149-154. doi: 10.1016/j. idairyj.2008.10.004 Derraik, J. G. B. (2009). Association between habitat size, brushtail possum density, and the mosquito fauna of native forests in the Auckland region, New Zealand. EcoHealth, 6, 229-238. doi: 10.1007/s10393-009-0238-9 Dickson, G. C., Poulter, R., Maas, E. W., Probert, P. K., & Kieser, J. A. (2010). Marine bacterial succession as a potential indicator of postmortem submersion interval. Forensic Science International, Advance Online Publication. doi: 10.1016/j. forsciint.2010.10.016 Duncan, A. R., Priest, P. C., Jennings, L. C., Brunton, C. R., & Baker, M. G. (2009). Screening for influenza infection in international airline travelers. American Journal of Public Health, 99(Suppl. 2), S360-S362. doi: 10.2105/AJPH.2008.158071 Edwards, R. (2009). Spousal smoking as an indicator of total secondhand smoke exposure. Nicotine & Tobacco Research, 11(6), 606-613. doi: 10.1093/ntr/ntp024 Edwards, R., Gifford, H., Waa, A., Glover, M., Thomson, G., & Wilson, N. (2009). Beneficial impacts of a national smokefree environments law on an indigenous population: A multifaceted evaluation. International Journal for Equity in Health, 8. doi: 10.1186/1475-9276-8-12 Eichner, M., Schwehm, M., Wilson, N., & Baker, M. G. (2009). Small islands and pandemic influenza: Potential benefits and limitations of travel volume reduction as a border control measure. BMC Infectious Diseases, 9, 160. doi: 10.1186/1471- 2334-9-160 Elkin, L., Thomson, G., & Wilson, N. (2010). Connecting world youth with tobacco brands: YouTube and the internet policy vacuum on Web 2.0. Tobacco Control, Advance Online Publication. doi: 10.1136/tc.2010.035949 Eyles, H., Ni Mhurchu, C., Wharemate, L., Funaki-Tahifote, M., Lanumata, T., & Rodgers, A. (2009). Developing nutrition education resources for a multi-ethnic population in New Zealand. Health Education Research, 24(4), 558-574. doi: 10.1093/her/cyn057 Free, S., Howden-Chapman, P., Pierse, N., Viggers, H., the Housing, Heating and Health Study Research Team, including Nicholls, S., Bennett, J., Shields, D., Lloyd, B., Wickens, K., Baker, M., & Crane, J. (2010). More effective home heating reduces school absences for children with asthma. Journal of Epidemiology and Community Health, 64(5), 379-386. doi: 10.1136/jech.2008.086520 Gifford, H., Parata, K., & Thomson, G. (2010). Māori challenges and crown responsibilities: Māori policymaker ideas on smokefree policy options. New Zealand Medical Journal, 123(1326). Retrieved from http://www.nzma.org.nz/ journal/123-1326/4443/content.pdf Gillespie-Bennett, J., Pierse, N., Wickens, K., Crane, J., Howden-Chapman, P., the Housing, Heating and Health Study Research

Team, including Viggers, H., & Lloyd, B. (2010). The respiratory health effects of nitrogen dioxide (NO2) in children with asthma. European Respiratory Journal, Advance Online Publication. doi: 10.1183/09031936.00115409 Goulding, A., Taylor, R. W., Grant, A. M., Parnell, W. R., Wilson, N., Wilson, N. C., & Williams, S. M. (2010). Waist-to-height ratios in relation to BMI z-scores in three ethnic groups from a representative sample of New Zealand children aged 5-14 years. International Journal of Obesity, 34, 1188-1190. doi: 10.1038/ijo.2009.278

202 RESEARCH REPORT 2009/2010 Gunasekara, F. I., Carter, K., & Blakely, T. (2010). Change in income and change in self-rated health: Systematic review of studies using repeated measures to control for confounding bias. Social Science and Medicine, Advance Online Publication. doi: 10.1016/j.socscimed.2010.10.029 Hadorn, D. (2010). Moving forward with healthcare prioritisation. New Zealand Medical Journal, 123(1326). Retrieved from http://www.nzma.org.nz/journal/123-1326/4446/ Hajat, A., Blakely, T., Dayal, S., & Jatrana, S. (2010). Do New Zealand’s immigrants have a mortality advantage? Evidence from the New Zealand Census-Mortality Study. Ethnicity & Health, 15(5), 531-547. doi: 10.1080/13557858.2010.496479 Hales, S., Blakely, T., Foster, R. H., Baker, M. G., & Howden-Chapman, P. (2010). Seasonal patterns of mortality in relation to social factors. Journal of Epidemiology and Community Health, Advance Online Publication. doi: 10.1136/jech.2010.111864 Hales, S., Blakely, T., & Woodward, A. (2010). Air pollution and mortality in New Zealand: Cohort study. Journal of Epidemiology and Community Health, Advance Online Publication. doi: 10.1136/jech.2010.112490 Halkett, L., & Thomson, G. (2010). Getting an outdoor smokefree policy: The case of Kapiti Coast District Council. New Zealand Medical Journal, 123(1308). Retrieved from http://www.nzma.org.nz/journal/archive.shtml Heyes, J. C., Siebers, R. W., Parkes, A., Pierse, N., & Crane, J. (2009). b-(1,3)-glucan levels and its determinants in New Zealand bedrooms. Journal of Asthma, 46(1), 64-66. doi: 10.1080/02770900802478326 Hill, S. E., Njie, O., Sanneh, M., ..., Hill, P. C., et al. (2009). Oxygen for treatment of severe pneumonia in The Gambia, West Africa: A situational analysis. International Journal of Tuberculosis and Lung Disease, 13(5), 587-593. Hill, S., Sarfati, D., Blakely, T., Robson, B., Purdie, G., Chen, J., Dennett, E., Cormack, D., Cunningham, R., Dew, K., McCreanor, T., & Kawachi, I. (2010). Survival disparities in indigenous and non-indigenous New Zealanders with colon cancer: The role of patient comorbidity, treatment and health service factors. Journal of Epidemiology and Community Health, 64(2), 117-123. doi: 10.1136/jech.2008.083816 Hill, S., Sarfati, D., Blakely, T., Robson, B., Purdie, G., Dennett, E., Cormack, D., Dew, K., Ayanian, J. Z., & Kawachi, I. (2010). Ethnicity and management of colon cancer in New zealand: Do indigenous patients get a worse deal? Cancer, 116(13), 3205-3214. doi: 10.1002/cncr.25127 Hoek, J., Gifford, H., Pirikahu, G., Thomson, G., & Edwards, R. (2010). How do tobacco retail displays affect cessation attempts? Findings from a qualitative study. Tobacco Control, 19(4), 334-337. doi: 10.1136/tc.2009.031203 Hoek, J., Wilson, N., Allen, M., Edwards, R., Thomson, G., & Li, J. (2010). Lessons from New Zealand’s introduction of pictorial health warnings on tobacco packaging. Bulletin of the World Health Organization, 88(11), 861-866. doi: 10.2471/ BLT.10.076695 Horsburgh, S., Norris, P., Becket, G., Crampton, P., Arroll, B., Cumming, J. M., Herbison, P., & Sides, G. (2010). The Equity in Prescription Medicines Use study: Using community pharmacy databases to study medicines utilisation. Journal of Biomedical Informatics, Advance Online Publication. doi: 10.1016/j.jbi.2010.08.004 Howden-Chapman, P. (2010). Evidence-based politics: How successful have government reviews been as policy instruments to reduce health inequalities in England? Social Science and Medicine, 71(7), 1240-1243. doi: 10.1016/j.socscimed.2010.07.012 Howden-Chapman, P., Viggers, H., Chapman, R., O’Dea, D. J., Free, S., & O’Sullivan, K. (2009). Warm homes: Drivers of the demand for heating in the residential sector in New Zealand. Energy Policy, 37(9), 3387-3399. doi: 10.1016/j. enpol.2008.12.023 Howie, S. R. C., Hill, S., Ebonyi, A., ..., Hill, P. C., et al. (2009). Meeting oxygen needs in Africa: An options analysis from the Gambia. Bulletin of the World Health Organization, 87(10), 763-771. doi: 10.2471/blt.08.058370 Huang, Q. S., Bandaranayake, D., Lopez, L. D., ..., Jennings, L., ..., & Baker, M. (2009). Surveillance for the 2009 pandemic influenza A (H1N1) virus and seasonal influenza viruses: New Zealand, 2009. Morbidity and Mortality Weekly Report, 58(33), 918-921. Hyslop, B., & Thomson, G. (2009). Smokefree outdoor areas without the smoke-police: The New Zealand local authority experience. New Zealand Medical Journal, 122(1303). Retrieved from http://www.nzma.org.nz/journal/122-1303/3797/ Jaine, R., Baker, M., & Venugopal, K. (2010). Acute rheumatic fever associated with household crowding in a developed country. Pediatric Infectious Disease Journal, Advance Online Publication. doi: 10.1097/INF.0b013e3181fbd85b Jatrana, S., & Crampton, P. (2009). Affiliation with a primary care provider in New Zealand: Who is, who isn’t. Health Policy, 91(3), 286-296. doi: 10.1016/j.healthpol.2008.12.015 Jatrana, S., & Crampton, P. (2009). Gender differences in general practice utilisation in New Zealand. Journal of Primary Health Care, 1(4), 261-269. Jatrana, S., & Crampton, P. (2009). Primary health care in New Zealand: Who has access? Health Policy, 93(1), 1-10. doi: 10.1016/j.healthpol.2009.05.006 Jatrana, S., Crampton, P., & Filoche, S. (2009). The case for integrating oral health into primary health care. New Zealand Medical Journal, 122(1301). Retrieved from http://www.nzma.org.nz/journal/122-1301/3751/ Jatrana, S., Crampton, P., & Norris, P. (2010). Ethnic differences in access to prescription medication because of cost in New Zealand. Journal of Epidemiology and Community Health, Advance Online Publication. doi: 10.1136/jech.2009.099101 Jeffreys, M., Sarfati, D., Stevanovic, V., Tobias, M., Lewis, C., Pearce, N., & Blakely, T. (2009). Socioeconomic inequalities in cancer survival in New Zealand: The role of extent of disease at diagnosis. Cancer Epidemiology Biomarkers & Prevention, 18(3), 915-921. doi: 10.1158/1055-9965.epi-08-0685 Jenkin, G., Wilson, N., & Hermanson, N. (2009). Identifying ‘unhealthy’ food advertising on television: A case study applying the UK Nutrient Profile model. Public Health Nutrition, 12(5), 614-623. doi: 10.1017/S1368980008003029 Kazantis, N., Flett, R. A., Long, N. R., MacDonald, C., Millar, M., & Clark, B. (2010). Traumatic events and mental health in the community: A New Zealand study. International Journal of Social Psychiatry, 56(1), 35-49. doi: 10.1177/0020764008095929

Division of HEALTH SCIENCES 203 Keall, M., Baker, M. G., Howden-Chapman, P., Cunningham, M., & Ormandy, D. (2010). Assessing housing quality and its impact on health, safety and sustainability. Journal of Epidemiology and Community Health, 64, 765-771. doi: 10.1136/ jech.2009.100701 Keall, M. D., Guria, J., Howden-Chapman, P., & Baker, M. G. (2010). Estimation of the social costs of home injury: A comparison with estimates for road injury. Accident Analysis and Prevention, Advance Online Publication. doi: 10.1016/j. aap.2010.11.027 Keall, M. D., & Newstead, S. (2010). Passenger vehicle safety in Australasia for different driver groups. Accident Analysis and Prevention, Advance Online Publication. doi: 10.1016/j.aap.2010.10.012 Keall, M., & Newstead, S. (2009). Induced exposure estimates of rollover risk for different types of passenger vehicles. Traffic Injury Prevention, 10(1), 30-36. doi: 10.1080/15389580802383117 Keall, M., & Newstead, S. (2009). Selection of comparison crash types for quasi-induced exposure risk estimation. Traffic Injury Prevention, 10(1), 23-29. doi: 10.1080/15389580802383125 Lahausse, J. A., van Nes, N., Fildes, B. N., & Keall, M. D. (2010). Attitudes towards current and lowered speed limits in Australia. Accident Analysis and Prevention, Advance Online Publication. doi: 10.1016/j.aap.2010.06.024 Lake, R. J., Adlam, S. B., Perera, S., Campbell, D. M., & Baker, M. G. (2010). The disease pyramid for acute gastrointestinal illness in New Zealand. Epidemiology and Infection, 138, 1468-1471. doi: 10.1017/S0950268810000397 Lanumata, T., & Thomson, G. (2009). Unequal risks, unmet needs: The tobacco burden for Pacific peoples in New Zealand. New Zealand Medical Journal, 122(1303). Retrieved from http://www.nzma.org.nz/journal/122-1303/3795/ Lanumata, T., Thomson, G., & Wilson, N. (2010). Pacific solutions to reducing smoking around Pacific children in New Zealand: A qualitative study of Pacific policymaker views. New Zealand Medical Journal, 123(1308). Retrieved from http:// www.nzma.org.nz/journal/archive.shtml Lawton, B. A., Rose, S. B., Elley, C. R., Bromhead, C., MacDonald, E. J., & Baker, M. G. (2010). Increasing the uptake of opportunistic chlamydia screening: A pilot study in general practice. Journal of Primary Health Care, 2(3), 199-207. Li, J., Grigg, M., Weerasekera, D., & Yeh, L-C. (2010). Characteristics and quitting success of roll-your-own versus tailor-made cigarette smokers. New Zealand Medical Journal, 123(1308). Retrieved from http://www.nzma.org.nz/ journal/123-1308/3947/content.pdf Markandya, A., Armstrong, B., Hales, S., Chiabai, A., Criqui, P., et al. (2009). Public health benefits of strategies to reduce greenhouse-gas emissions: Low-carbon electricity generation. Lancet, 374(9706), 2006-2015. doi: 10.1016/S0140- 6736(09)61715-3 Mbeh, G. N., Edwards, R., Ngufor, G., Assah, F., Fezeu, L., & Mbanya, J-C. (2010). Traditional healers and diabetes: Results from a pilot project to train traditional healers to provide health education and appropriate health care practices for diabetes patients in Cameroon. Global Health Promotion, 17(Suppl. 2), 17-26. doi: 10.1177/1757975910363925 McKenzie, S., & Carter, K. (2010). Measuring Whānau: A review of longitudinal studies in New Zealand. MAI Review, 3. Retrieved from http://www.review.mai.ac.nz/index.php/MR/issue/view/17 McKenzie, S. K., Carter, K., Blakely, T., & Collings, S. (2010). The association of childhood socio-economic position and psychological distress in adulthood: Is it mediated by adult socio-economic position? Longitudinal and Life Course Studies, 1(4), 339-358. McLeod, M., Harris, R., Purdie, G., Cormack, D., Robson, B., Sykes, P., et al. (2010). Improving survival disparities in cervical cancer between Mäori and non-Mäori women in New Zealand: A National Retrospective Cohort Study. Australian and New Zealand Journal of Public Health, 34(2), 193-199. doi: 10.1111/j.1753-6405.2010.00506.x McMichael, A. J., Neira, M., Bertollini, R., Campbell-Lendrum, D., & Hales, S. (2009). Climate change: A time of need and opportunity for the health sector. Lancet, 374(9707), 2123-2125. doi: 10.1016/S0140-6736(09)62031-6 Metcalfe, S., Woodward, A., Macmillan, A., Baker, M., Howden-Chapman, P., Lindsay, G., Hales, S., ..., Edwards, R., et al. (2009). Why New Zealand must rapidly halve its greenhouse gas emissions. New Zealand Medical Journal, 122(1304). Retrieved from http://www.nzma.org.nz/journal/122-1304/3827/content.pdf Mhurchu, C. N., Blakely, T., Jiang, Y., Eyles, H. C., & Rodgers, A. (2010). Effects of price discounts and tailored nutrition education on supermarket purchases: A randomized controlled trial. American Journal of Clinical Nutrition, 91(3), 736- 747. doi: 10.3945/ajcn.2009.28742 Mihaere, K. M., Harris, R., Gander, P. H., Reid, P. M., Purdie, G., Robson, B., & Neill, A. (2009). Obstructive sleep apnea in New Zealand adults: Prevalence and risk factors among Mäori and non-Mäori. Sleep, 32(7), 949-956. Millar, E., Baker, M. G., Howden-Chapman, P., Wilson, N., & Dickson, N. (2009). Involving students in real-world research: A pilot study for teaching public health and research skills. BMC Medical Education, 9. doi: 10.1186/1472-6920-9-45 Murray, R., Chandler, C., Clarkson, Y., Wilson, N., Baker, M., Cunningham, R., & Wellington Respiratory and Hand Hygiene Study Group (2009). Sub-optimal hand sanitiser usage in a hospital entrance during an influenza pandemic, New Zealand, August 2009. Eurosurveillance, 14(37). Retrieved from http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19331 Newstead, S. V., Keall, M. D., & Watson, L. M. (2010). Rating the overall secondary safety of vehicles from real world crash data: The Australian and New Zealand Total Secondary Safety Index. Accident Analysis & Prevention, Advance Online Publication. doi: 10.1016/j.aap.2010.10.005 Ni Mhurchu, C., Blakely, T., Funaki-Tahifote, M., McKerchar, C., Wilton, J., Chua, S., & Jiang, Y. (2009). Inclusion of indigenous and ethnic minority populations in intervention trials: Challenges and strategies in a New Zealand supermarket study. Journal of Epidemiology and Community Health, 63(10), 850-855. doi: 10.1136/jech.2008.081109 Nishiura, H., Wilson, N., & Baker, M. G. (2009). Quarantine for pandemic influenza control at the borders of small island nations. BMC Infectious Diseases, 9. doi: 10.1186/1471-2334-9-27

204 RESEARCH REPORT 2009/2010 O’Brien, I., Britton, E. J., Sarfati, D., Naylor, W., Borman, B., Ellison-Loschmann, L., Simpson, A., Tamblyn, C., & Atkinson, C. (2010). The voice of experience: Results from Cancer Control New Zealand’s first national cancer care survey. New Zealand Medical Journal, 123(1325). Retrieved from http://www.nzma.org.nz/journal/123-1325/4419/content.pdf O’Sullivan, C. E., & Baker, M. G. (2010). Proposed epidemiological case definition for serious skin infection in children. Journal of Paediatrics and Child Health, 46, 176-183. doi: 10.1111/j.1440-1754.2009.01658.x O’Sullivan, C. E., Baker, M. G., & Zhang, J. (2010). Increasing hospitalizations for serious skin infections in New Zealand children, 1990-2007. Epidemiology and Infection, Advance Online Publication. doi: 10.1017/S0950268810002761 O’Sullivan, K. C., Howden-Chapman, P. L., & Fougere, G. (2010). Making the connection: The relationship between fuel poverty, electricity disconnection, and prepayment metering. Energy Policy, Advance Online Publication. doi: 10.1016/j. enpol.2010.10.046 Paine, S., Mercer, G. N., Kelly, P. M., Bandaranayake, D., Baker, M. G., Huang, Q. S., et al. (2010). Transmissibility of 2009 pandemic influenza A(H1N1) in New Zealand: Effective reproduction number and influence of age, ethnicity and importations. Eurosurveillance, 15(24), 9-17. Paynter, J., & Edwards, R. (2009). The impact of tobacco promotion at the point of sale: A systematic review. Nicotine & Tobacco Research, 11(1), 25-35. doi: 10.1093/ntr/ntn002 Paynter, J., Edwards, R., Schluter, P. J., & McDuff, I. (2009). Point of sale tobacco displays and smoking among 14-15 year olds in New Zealand: A cross-sectional study. Tobacco Control, 18(4), 268-274. doi: 10.1136/tc.2008.027482 Peace, J., Wilson, N., Hoek, J., Thomson, G., & Edwards, R. (2009). Survey of descriptors on cigarette packs: Still misleading consumers? New Zealand Medical Journal, 122(1303). Retrieved from http://www.nzma.org.nz/journal/122-1303/3801/ Pearce, J., Hiscock, R., Blakely, T., & Witten, K. (2009). A national study of the association between neighbourhood access to fast-food outlets and the diet and weight of local residents. Health & Place, 15(1), 193-197. doi: 10.1016/j. healthplace.2008.04.003 Pollock, S., Signal, L., & Watts, C. (2009). Supermarket discounts: Are they promoting healthy non-alcoholic beverages? Nutrition and Dietetics, 66(2), 101-107. doi: 10.1111/j.1747-0080.2009.01336.x Preval, N., Chapman, R., Pierse, N., Howden-Chapman, P., & the Housing, Heating and Health Study Research Team (2010). Evaluating energy, health and carbon co-benefits from improved domestic space heating: A randomised community trial. Energy Policy, 38(8), 3965-3972. doi: 10.1016/j.enpol.2010.03.020 Purdie, G., Harrison, A., & Purdie, D. (2009). Prevalence of Raynaud’s phenomenon in the adult New Zealand population. New Zealand Medical Journal, 122(1306). Retrieved from http://www.nzma.org.nz/journal/122-1306/3890/ Richardson, K., Blakely, T., Young, J., Graham, P., & Tobias, M. (2009). Do ethnic and socio-economic inequalities in mortality vary by region in New Zealand? An application of hierarchical Bayesian modelling. Social Science and Medicine, 69(8), 1252-1260. doi: 10.1016/j.socscimed.2009.07.036 Rose, S. B., Lawton, B. A., Lanumata, T., Hibma, M., & Baker, M. G. (2010). HPV/cervical cancer vaccination: Parental preferences on age, place and information needs. Journal of Primary Health Care, 2(3), 190-198. Rouch, G., Thomson, G., Wilson, N., Hudson, S., Edwards, R., Gifford, H., & Lanumata, T. (2010). Public, private and personal: Qualitative research on policymaker’s opinions on smokefree interventions to protect children in ‘private’ spaces. BMC Public Health, 10, 797. doi: 10.1186/1471-2458-10-797 Russell, M., Buckley, S., Walton, C., Gerring, Z., & Black, J. (2009). Abusive and inappropriate sexual behaviour among Years 7 and 8 students: A survey of teachers. set: Research Information for Teachers, 1, 5-11. Sapre, N., Munting, K., Pandita, A., & Stubbs, R. (2009). Pregnancy following gastric bypass surgery: What is the expected course and outcome? New Zealand Medical Journal, 122(1306). Retrieved from http://www.nzma.org.nz/ journal/122-1306/3886/ Sarfati, D., Blakely, T., & Pearce, N. (2010). Measuring cancer survival in populations: Relative survival vs cancer-specific survival. International Journal of Epidemiology, 39, 598-610. doi: 10.1093/ije/dyp392 Sarfati, D., Hill, S., Blakely, T., Robson, B., Purdie, G., Dennett, E., Cormack, D., & Dew, K. (2009). The effect of comorbidity on the use of adjuvant chemotherapy and survival from colon cancer: A retrospective cohort study. BMC Cancer, 9, 116. doi: 10.1186/1471-2407-9-116 Sarfati, D., Hill, S., Purdie, G., Dennett, E., & Blakely, T. (2010). How well does routine hospitalisation data capture information on comorbidity in New Zealand? New Zealand Medical Journal, 123(1310). Retrieved from http://www.nzma. org.nz/journal/123-1310/4010/ Scott, K. M., & Collings, S. C. D. (2010). Gender and the association between mental disorders and disability. Journal of Affective Disorders, 125, 207-212. doi: 10.1016/j.jad.2010.06.022 Shaw, C. (2009). (Non)regulation of marketing of unhealthy food to children in New Zealand. New Zealand Medical Journal, 122(1288). Retrieved from http://www.nzma.org.nz/journal/122-1288/3431/ Shaw, C., Atkinson, J., & Blakely, T. (2009). (Mis)classification of ethnicity on the New Zealand Cancer Registry: 1981-2004. New Zealand Medical Journal, 122(1294). Retrieved from http://www.nzma.org.nz/journal/122-1294/3578/ Smith, M. B. (2010). Oral health and well-being of older adults in residential aged-care facilities: Issues for public health policy. New Zealand Dental Journal, 106(2), 67-73. Smith, M. B., & Signal, L. (2009). Global influences on milk purchasing in New Zealand: Implications for health and inequalities. Globalization and Health, 5. doi: 10.1186/1744-8603-5-1 Snel, S. J., Baker, M. G., Kamalesh, V., French, N., & Learmonth, J. (2009). A tale of two parasites: The comparative epidemiology of cryptosporidiosis and giardiasis. Epidemiology and Infection, 137, 1641-1650. doi: 10.1017/ S0950268809002465

Division of HEALTH SCIENCES 205 Snel, S. J., Baker, M. G., & Venugopal, K. (2009). The epidemiology of cryptosporidiosis in New Zealand, 1997-2006. New Zealand Medical Journal, 122(1290). Retrieved from http://www.nzma.org.nz/journal/122-1290/3479/ Snel, S. J., Baker, M. G., & Venugopal, K. (2009). The epidemiology of giardiasis in New Zealand, 1997-2006. New Zealand Medical Journal, 122(1290). Retrieved from http://www.nzma.org.nz/journal/122-1290/3480/ Stanley, J., Gowen, E., & Miall, R. C. (2010). How instructions modify perception: An fMRI study investigating brain areas involved in attributing human agency. NeuroImage, 52, 389-400. doi: 10.1016/j.neuroimage.2010.04.025 Stevenson, A., Pearce, J., Blakely, T., Ivory, V., & Witten, K. (2009). Neighbourhoods and health: A review of the New Zealand literature. New Zealand Geographer, 65(3), 211-221. doi: 10.1111/j.1745-7939.2009.01164.x Strand, B. H., Grøholt, E-K., Steingrímsdóttir, O. A., Blakely, T., Graff-Iversen, S., & Næss, O. (2010). Educational inequalities in mortality over four decades in Norway: Prospective study of middle aged men and women followed for cause specific mortality, 1960-2000. BMJ, 340, c654. doi: 10.1136/bmj.c654 Summers, J. A., Wilson, N., Baker, M. G., & Shanks, G. D. (2010). Mortality risk factors for pandemic influenza on New Zealand troop ship, 1918. Emerging Infectious Diseases, 16(12), 1931-1937. doi: 10.3201/eid1612.100429 Tan, L., Blakely, T., & Atkinson, J. (2010). Ethnic counts on mortality and census data 2001-06: New Zealand census-mortality study update. New Zealand Medical Journal, 123(1320). Retrieved from http://www.nzma.org.nz/journal/archive.php Tapp, D., & Thomson, G. (2009). Smokefree cars in New Zealand: Rapid research among stakeholders on attitudes and future directions. New Zealand Medical Journal, 122(1303). Retrieved from http://www.nzma.org.nz/journal/122-1303/3799/ Thomson, G., Hudson, S., Wilson, N., & Edwards, R. (2010). A qualitative case study of policy maker views about the protection of children from smoking in cars. Nicotine & Tobacco Research, 12(9), 970-977. doi: 10.1093/ntr/ntq124 Thomson, G., & Wilson, N. (2009). Public attitudes to laws for smoke-free private vehicles: A brief review. Tobacco Control, 18(4), 256-261. doi: 10.1136/tc.2008.027672 Thomson, G., Wilson, N., Blakely, T., & Edwards, R. (2010). Ending appreciable tobacco use in a nation: Using a sinking lid on supply. Tobacco Control, 19(5), 431-435. doi: 10.1136/tc.2010.036681 Thomson, G., Wilson, N., & Edwards, R. (2009). At the frontier of tobacco control: A brief review of public attitudes toward smoke-free outdoor places. Nicotine & Tobacco Research, 11(6), 584-590. doi: 10.1093/ntr/ntp046 Thornley, L., Signal, L., & Thomson, G. (2010). Does industry regulation of food advertising protect child rights? Critical Public Health, 20(1), 25-33. doi: 10.1080/09581590802566461 Tobias, M., Blakely, T., Matheson, D., Rasanathan, K., & Atkinson, J. (2009). Changing trends in indigenous inequalities in mortality: Lessons from New Zealand. International Journal of Epidemiology, 38(6), 1711-1722. doi: 10.1093/ije/dyp156 Walton, M., Pearce, J., & Day, P. (2009). Examining the interaction between food outlets and outdoor food advertisements with primary school food environments. Health and Place, 15(3), 841-848. doi: 10.1016/j.healthplace.2009.02.003 Walton, M., Signal, L., & Thomson, G. (2009). Household economic resources as a determinant of childhood nutrition: Policy responses for New Zealand. Social Policy Journal of New Zealand, 36, 194-207. Walton, M., Waiti, J., Signal, L., & Thomson, G. (2010). Identifying barriers to promoting healthy nutrition in New Zealand primary schools. Health Education Journal, 69(1), 84-94. doi: 10.1177/0017896910363152 Welchman, A. E., Stanley, J., Schomers, M. R., Miall, R. C., & Bülthoff, H. H. (2010). The quick and the dead: When reaction beats intention. Proceedings of the Royal Society B, 277(1688), 1667-1674. doi: 10.1098/rspb.2009.2123 Wilson, H., & Thomson, G. (2010). ‘Balancing acts’: The politics and processes of smokefree area policymaking in a small state. Health Policy, Advance Online Publication. doi: 10.1016/j.healthpol.2010.08.017 Wilson, N., & Baker, M. G. (2009). Comparison of the content of the New Zealand influenza pandemic plan with European pandemic plans. New Zealand Medical Journal, 122(1290). Retrieved from http://www.nzma.org.nz/journal/archive.shtml Wilson, N., & Baker, M. G. (2009). The emerging influenza pandemic: Estimating the case fatality ratio. Eurosurveillance, 14(26). Retrieved from http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19255 Wilson, N., Blakely, T., Edwards, R., Weerasekera, D., & Thomson, G. (2009). Support by New Zealand smokers for new types of smokefree areas: National survey data. New Zealand Medical Journal, 122(1303). Retrieved from http://www.nzma.org. nz/journal/archive.shtml Wilson, N., Borland, R., Weerasekera, D., Edwards, R., & Russell, M. (2009). Smoker interest in lower harm alternatives to cigarettes: National survey data. Nicotine and Tobacco Research, 11(12), 1467-1473. doi: 10.1093/ntr/ntp152 Wilson, N., Mason, K., Tobias, M., Peacey, M., Huang, Q. S., & Baker, M. (2009). Interpreting ²Google flu trends² data for pandemic H1N1 influenza: The New Zealand experience. EuroSurveillance, 14(44), 19386. Retrieved from http://www. eurosurveillance.org/ViewArticle.aspx?ArticleId=19386 Wilson, N., Peace, J., Li, J., Edwards, R., Hoek, J., Stanley, J., & Thomson, G. (2009). Distribution of new graphic warning labels: Are tobacco companies following regulations? Tobacco Induced Diseases, 5(1), 14. doi: 10.1186/1617-9625-5-14 Wilson, N., Thomson, G., Edwards, R., & Peace, J. (2009). Estimating missed government tax revenue from foreign tobacco: Survey of discarded cigarette packs. Tobacco Control, 18(5), 416-418. doi: 10.1136/tc.2009.031278 Wilson, N., Weerasekera, D., Blakely, T., Edwards, R., Thomson, G., & Gifford, H. (2010). What is behind smoker support for new smokefree areas? National survey data. BMC Public Health, 10, 498. doi: 10.1186/1471-2458-10-498 Wilson, N., Weerasekera, D., Borland, R., Edwards, R., Bullen, C., & Li, J. (2010). Use of a national quitline and variation in use by smoker characteristics: ITC Project New Zealand. Nicotine & Tobacco Research, 12(Suppl. 1), S78-S84. doi: 10.1093/ntr/ ntq111 Wilson, N., Weerasekera, D., Edwards, R., Thomson, G., Devlin, M., & Gifford, H. (2010). Characteristics of smoker support for increasing a dedicated tobacco tax: National survey data from New Zealand. Nicotine & Tobacco Research, 12(2), 168- 173. doi: 10.1093/ntr/ntp178

206 RESEARCH REPORT 2009/2010 Wilson, N., Weerasekera, D., Hoek, J., Li, J., & Edwards, R. (2010). Increased smoker recognition of a national quitline number following introduction of improved pack warnings: ITC Project New Zealand. Nicotine & Tobacco Research, 12(Suppl. 1), S72-S77. doi: 10.1093/ntr/ntq092 Wilson, N., Weerasekera, D., Peace, J., Edwards, R., Thomson, G., & Devlin, M. (2009). Misperceptions of ‘Light’ cigarettes abound: National survey data. BMC Public Health, 9. doi: 10.1186/1471-2458-9-126 Wood, C., D’Souza, A., & Carter, J. M. (2010). A single centre review investigating whether the transport times of mud stem cells influences engraftment times post hsct. Biology of Blood and Marrow Transplantation, 16(2, Supplement 1), S285-S286. doi: 10.1016/j.bbmt.2009.12.388 Wu, F. F-S., Chang, C-F., Wu, M-W., Pierse, N., & Siebers, R. (2010). Prevalence of macrocytosis in patients with chronic obstructive pulmonary disease. New Zealand Journal of Medical Laboratory Science, 64, 86-87. Wu, F. F-S., Siebers, R., Chang, C-F., Hsieh, S-W., Wu, M-W., Chen, C-Y., Pierse, N., & Crane, J. (2009). Indoor allergens and microbial bio-contaminants in homes of asthmatic children in Central Taiwan. Journal of Asthma, 46(7), 745-749. doi: 10.1080/02770900903082597 Wu, F. F-S., Wu, M-W., Chang, C-F., Lai, S-M., Pierse, N., Crane, J., & Siebers, R. (2010). Endotoxin and b-(1,3)-glucan levels in automobiles: A pilot study. Annals of Agricultural and Environmental Medicine, 17(2), 327-330. Wyber, R., Wilson, N., & Baker, M. (2009). New Zealand’s impact on health in the South Pacific: Scope for improvement? New Zealand Medical Journal, 122(1291). Retrieved from http://www.nzma.org.nz/journal/122-1291/3505/ Young, D., Wilson, N., Borland, R., Edwards, R., & Weerasekera, D. (2010). Prevalence, correlates of, and reasons for using Roll-Your-Own tobacco in a high RYO use country: Findings from the ITC New Zealand survey. Nicotine & Tobacco Research, 12(11), 1089-1098. doi: 10.1093/ntr/ntq155 Zhao, P. (2010). Managing urban growth in a transforming China: Evidence from Beijing. Land Use Policy, 28, 96-109. doi: 10.1016/j.landusepol.2010.05.004 Zhao, P., & Howden-Chapman, P. (2010). Social inequalities in mobility: The impact of the hukou system on migrants’ job accessibility and commuting costs in Beijing. International Development Planning Review, 32(3-4), 363-384. doi: 10.3828/ idpr.2010.13 Zhao, P., Lü, B., & de Roo, G. (2010). Urban expansion and transportation: The impact of urban form on commuting patterns on the city fringe of Beijing. Environment and Planning A, 42(10), 2467-2486. doi: 10.1068/a4350 Zheng, T., Adlam, B., Rawdon, T. G., Stanislawek, W. L., Cork, S. C., Hope, V., Buddle, B. M., Grimwood, K., Baker, M. G., O’Keefe, J. S., & Huang, Q. S. (2010). A cross-sectional survey of influenza A infection, and management practices in small rural backyard poultry flocks in two regions of New Zealand. New Zealand Veterinary Journal, 58(2), 74-80.

Journal - Research Other Baker, M. G., Kelly, H., & Wilson, N. (2009). Pandemic H1N1 influenza lessons from the southern hemisphere [Editorial]. Euro Surveillance, 14(42), 2-6. Blakely, T. (2010). [Review of the book Revolving doors: New Zealand’s health reforms - the continuing saga]. Australian and New Zealand Journal of Public Health, 34(4), 437-438. doi: 10.1111/j.1753-6405.2009.00584.x Blakely, T., Sarfati, D., & Shaw, C. (2009). What proportion of cancer is due to obesity? [Editorial]. New Zealand Medical Journal, 122(1290). Retrieved from http://www.nzma.org.nz/journal/122-1290/3478/ Blakely, T., Thomson, G., Wilson, N., Edwards, R., & Gifford, H. (2010). The Māori Affairs Select Committee Inquiry and the road to a smokefree Aotearoa [Editorial]. New Zealand Medical Journal, 123(1326). Retrieved from http://www.nzmj.org/ journal/123-1326/4448/ Carter, K. N., & Blakely, T. (2009). Selection bias: Importance of identification and adjustment [Comment]. Neuroepidemiology, 32(3), 240-241. Crampton, P. (2009). A primary care-led medical education system? [Guest editorial]. Journal of Primary Health Care, 1(1), 5-6. Edwards, R., Wilson, N., Thomson, G., Weerasekera, D., & Blakely, T. (2009). Majority support by Mäori and non-Mäori smokers for many aspects of increased tobacco control regulation: National survey data [Letters]. New Zealand Medical Journal, 122(1307). Retrieved from http://www.nzma.org.nz/journal/122-1307/3931/ Elkin, L. E., & Thomson, G. (2010). The extent of YouTube videos with smoking and smokefree words [Letter]. New Zealand Medical Journal, 123(1311). Retrieved from http://www.nzma.org.nz/journal/123-1311/4042/ Howden-Chapman, P., Robson, B., & Fougere, G. (2010). Life chances going up in smoke [Editorial]. New Zealand Medical Journal, 123(1320). Retrieved from http://www.nzma.org.nz/journal/archive.php Huthwaite, M. A., & Stanley, J. (2010). Lithium in drinking water [Correspondence]. British Journal of Psychiatry, 196(2), 159. doi: 10.1192/bjp.196.2.159 Imlach Gunasekara, F., & Wilson, N. (2010). Very cheap drinking in New Zealand: Some alcohol is more affordable than bottled water and nearly as cheap as milk [Letter]. New Zealand Medical Journal, 123(1324). Retrieved from http://www. nzma.org.nz/journal/123-1324/4396/ Imlach Gunasekara, F., Wilson, N., & Edwards, R. (2010). Is New Zealand lagging behind other OECD countries in measures to reduce alcohol-related harm? [Letter]. New Zealand Medical Journal, 123(1321). Retrieved from http://www.nzma.org. nz/journal/archive.php Manning, S., Barry, T., Wilson, N., & Baker, M. G. (2010). Update: Follow-up study showing post-pandemic decline in hand sanitiser use, New Zealand, December 2009 [Rapid communications]. Eurosurveillance, 15(3), 19466. Retrieved from http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19466

Division of HEALTH SCIENCES 207 Mathieson, F., Collings, S., & Dowell, A. (2009). Sub-threshold mental health syndromes: Finding an alternative to the medication of unhappiness [Essay]. Journal of Primary Health Care, 1(1), 74-77. McKenzie, S. K., & Carter, K. N. (2009). Are retrospective measures of childhood socioeconomic position in prospective adult health surveys useful? [Roundtable: Lifecourse epidemiology]. Australasian Epidemiologist, 16(3), 22-24. Nishiura, H., & Wilson, N. (2009). Transmission dynamics of the 1918 influenza pandemic in New Zealand: Analyses of national and city data [Letter to the editor]. New Zealand Medical Journal, 122(1296). Retrieved from http://www.nzma. org.nz/journal/122-1296/3649/ Nishiura, H., Wilson, N., & Baker, M. G. (2009). Estimating the reproduction number of the novel influenza A virus (H1N1) in a Southern Hemisphere setting: Preliminary estimate in New Zealand [Letter to the editor]. New Zealand Medical Journal, 122(1299). Retrieved from http://www.nzma.org.nz/journal/122-1299/3722/ Rochford, T., & Signal, L. (2009). Using a framework of Mäori models for health to promote the health of Mäori. Keeping Up to Date, 29-30, I-VI. Sarfati, D., Hill, S., Blakely, T., & Robson, B. (2010). Is bowel cancer screening important for Māori? [Editorial]. New Zealand Medical Journal, 123(1320). Retrieved from http://www.nzma.org.nz/journal/123-1320/4266/content.pdf Sarfati, D., Shaw, C., & Simmonds, S. (2010). Inequalities in cancer screening programmes [Commentary]. International Journal of Epidemiology, 39, 766-768. doi: 10.1093/ije/dyq039 Schwehm, M., Eichner, M., Wilson, N., & Baker, M. G. (2009). A freely available software tool for assessing aspects of pandemic influenza risk reduction for small islands [Letter]. New Zealand Medical Journal, 122(1295). Retrieved from http://www. nzma.org.nz/journal/122-1295/3624/ Schwehm, M., & Wilson, N. (2009). Potential impact of pandemic influenza interventions in New Zealand: A brief modelling study [Letters]. New Zealand Medical Journal, 122(1291). Retrieved from http://www.nzma.org.nz/journal/122-1291/3522/ Thomson, G., O’Dea, D., Wilson, N., & Edwards, R. (2010). Government paralysis? Stable tobacco prices mean preventable deaths and disease persist, along with health inequalities in New Zealand [Viewpoint]. New Zealand Medical Journal, 123(1308). Retrieved from http://www.nzma.org.nz/journal/archive.shtml Thomson, G., Weerasekera, D., & Wilson, N. (2009). New Zealand smokers’ attitudes to smokefree cars containing preschool children: Very high support across all sociodemographic groups [Letters]. New Zealand Medical Journal, 122(1300). Retrieved from http://www.nzma.org.nz/journal/122-1300/3739/ Thomson, G., White, J., & Signal, L. (2010). Front-of-pack nutrition labelling: Where to now? [Editorial]. New Zealand Medical Journal, 123(1324). Retrieved from http://www.nzma.org.nz/journal/123-1324/ Thomson, G., Wilson, N., & Edwards, R. (2010). Kiwi support for the end of tobacco sales: New Zealand governments lag behind public support for advanced tobacco control policies [Letter]. New Zealand Medical Journal, 123(1308). Retrieved from http://www.nzma.org.nz/journal/archive.shtml Thomson, G., Wilson, N., Edwards, R., & Woodward, A. (2009). Should smoking in outside public spaces be banned? Yes. BMJ, 337, 76. doi: 10.1136/bmj.a2806 Thomson, G., Wilson, N., Weerasekera, D., & Edwards, R. (2009). Most smokers support smokefree council-owned playgrounds: National survey data [Letters]. New Zealand Medical Journal, 122(1291). Retrieved from http://www.nzma. org/journal/122-1291/3523/ Tobias, M., & Harris, R. (2010). Racism and health in New Zealand [Editorial]. Ethnicity & Health, 15(4), 318-320. doi: 10.1080/13557858.2010.500803 Vukotich, Jr, C. J., Coulborn, R. M., Aragon, T. J., Baker, M. G., ..., Priest, P., et al. (2010). Findings, gaps, and future direction for research in nonpharmaceutical interventions for pandemic influenza [Conference Summary]. Emerging Infectious Diseases, 16(4). doi: 10.3201/eid1604.090719 Wilson, N., & Burford, L. (2009). Response [to Letter to the editor Additional impacts of regional nuclear war on New Zealand]. New Zealand Medical Journal, 122(1302). Retrieved from http://www.nzma.org.nz/journal/122-1302/3782/ Wilson, N., Burford, L., & Winnington, A. (2009). New software for modelling impacts of regional nuclear war: Relevance to New Zealand. New Zealand Medical Journal, 122(1298). Retrieved from http://www.nzma.org.nz/journal/122-1298/3694/ Wilson, N., Chapman, R., Clover, D., & Howden-Chapman, P. (2010). A farsighted energy strategy would benefit health in New Zealand [Letter]. New Zealand Medical Journal, 123(1322). Retrieved from http://www.nzma.org.nz/ journal/123-1322/4345/ Wilson, N., Chapman, R., & Howden-Chapman, P. (2009). New Zealand government response to climate change: Largely fogged up? [Letter to the editor]. New Zealand Medical Journal, 122(1303). Retrieved from http://www.nzma.org.nz/ journal/122-1303/3807/ Wilson, N., Cowie, R., Baker, M. G., & Howden-Chapman, P. (2010). Movies for use in public health training: A pilot method for movie selection and initial results [Letter to the editor]. Medical Teacher, 32(3), 270-271. doi: 10.3109/01421591003719525 Wilson, N., Edwards, R., Thomson, G., Weerasekera, D., Gifford, H., & Hoek, J. (2010). High and increased support by Māori and non-Mäori smokers for a ban on point-of-sale tobacco displays: National survey data [Letter]. New Zealand Medical Journal, 123(1317). Retrieved from http://www.nzma.org.nz/journal/archive.php Wilson, N., Edwards, R., & Weerasekera, D. (2009). High levels of smoker regret by ethnicity and socioeconomic status: National survey data [Letters]. New Zealand Medical Journal, 122(1292). Retrieved from http://www.nzma.org.nz/ journal/122-1292/3549/

208 RESEARCH REPORT 2009/2010 Wilson, N., Hoek, J., Peace, J., Gifford, H., Thomson, G., & Edwards, R. (2010). Marketing tobacco to New Zealand women: 8 ways to reflect on ²World No Tobacco Day² [Letter]. New Zealand Medical Journal, 123(1315). Retrieved from http://www. nzmj.org/journal/123-1315/ Wilson, N., Howden-Chapman, P., & Baker, M. G. (2010). Co-benefits and ‘no regrets’ benefits of influenza pandemic planning [Letter to the editor]. Influenza and other Respiratory Viruses, 4(3), 113-115. doi: 10.1111/j.1750-2659.2010.00133.x Wilson, N., Jarman, J., & Mansoor, O. (2009). Santé! Public health lessons from France for New Zealand [Letter to the editor]. New Zealand Medical Journal, 122(1296). Retrieved from http://www.nzma.org.nz/journal/122-1296/3650/ Wilson, N., Li, J., Hoek, J., Edwards, R., & Peace, J. (2010). Long-term benefit of increasing the prominence of a Quitline number on cigarette packaging: 3 years of Quitline call data [Letter]. New Zealand Medical Journal, 123(1321). Retrieved from http://www.nzma.org.nz/journal/archive.php Wilson, N., Lush, D., & Baker, M. G. (2010). Meteorological and climate change themes at the 2010 International Conference on Emerging Infectious Diseases [Conference Report]. Euro Surveillance, 15(30), 19627. Wilson, N., Peace, J., Edwards, R., & Weerasekera, D. (2010). Smokers commonly misperceive that nicotine is a major carcinogen: National survey data [Letter]. Thorax, Advance Online Publication. doi: 10.1136/thx.2010.141762 Wilson, N., Peace, J., Weerasekera, D., Hoek, J., & Edwards, R. (2010). Smoker (mis)perceptions associated with pack colouring: National survey data [Letter]. New Zealand Medical Journal, 123(1320). Retrieved from http://www.nzmj.org/ journal/archive.php Wilson, N., Summers, J., Baker, M., & Rice, G. (2009). A bizarre case of drowning as a result of pandemic influenza (1918 pandemic) [Clincial correspondence]. New Zealand Medical Journal, 122(1302). Retrieved from http://www.nzma.org.nz/ journal/122-1302/3777/ Wilson, N., Thomson, G., Blakely, T., & Edwards, R. (2010). A new opportunity to eliminate policy incoherence in tobacco control in New Zealand [Letter]. New Zealand Medical Journal, 123(1311). Retrieved from http://www.nzma.org.nz/ journal/archive.shtml Wilson, N., Thomson, G., & Edwards, R. (2009). What’s new in tobacco tax research for New Zealand and is it time for a tax hike now? [Letter to the editor]. New Zealand Medical Journal, 122(1293). Retrieved from http://www.nzma.org.nz/ journal/122-1293/3574/ Wilson, N., Thomson, G., Weerasekera, D., Blakely, T., Edwards, R., Peace, J., Young, D., & Gifford, H. (2009). Smoker misperceptions around tobacco: National survey data of particular relevance to protecting Mäori health [Letter to the editor]. New Zealand Medical Journal, 122(1306). Retrieved from http://www.nzma.org.nz/journal/122-1306/3897/ Wilson, N., Weerasekera, D., Collings, S., Edwards, R., & van der Deen, F. S. (2010). Poorer mental health in many New Zealand smokers: National survey data from the ITC project [Letter]. New Zealand Medical Journal, 123(1326). Retrieved from http://www.nzmj.org/journal/123-1326/4455/ Wilson, N., Weerasekera, D., Edwards, R., & Blakely, T. (2009). Smoker support for increased (if dedicated) tobacco tax by individual deprivation level: National survey data [Letter]. Tobacco Control, 18(6), 512. doi: 10.1136/tc.2009.031096 Wilson, N., Young, D., Weerasekera, D., Edwards, R., Thomson, G., & Glover, M. (2009). The importance of tobacco prices to roll-your-own (RYO) smokers (national survey data): Higher tax needed on RYO [Letter to the editor]. New Zealand Medical Journal, 122(1305). Retrieved from http://www.nzma.org.nz/journal/122-1305/3864/ Winnington, A., & Wilson, N. (2009). Medical student action and the ²Global Week of Action Against Gun Violence 2009² [Letter to the editor]. New Zealand Medical Journal, 122(1297). Retrieved from http://www.nzma.org.nz/ journal/122-1297/3673/

Journal - Professional & Other Non-Research Articles Brown, P., Callister, P., Carter, K., & Engler, R. (2010). Ethnic mobility: Is it important for research and policy analysis? Policy Quarterly, 6(3), 45-51. Edwards, R. (2009). [Review of the book Global efforts to combat smoking: An economic evaluation of smoking control policies]. Public Health, 123(2), 202. doi: 10.1016/j.puhe.2008.07.014 Hansen, S., Hoek, J., Sutton, R., & Thomson, G. (2010). Tobacco control haiku [Special Communication]. Tobacco Control, 19(4), 348. doi: 10.1136/tc.2009.033993 Thomson, G., & Wilson, H. (2010). Policymakers overlook children who sit in smoke-filled cars. New Zealand Herald, 22 April. Retrieved from http://www.nzherald.co.nz Thomson, G. W., & Russell, M. (2010). Public health haiku [Aphorism]. Journal of Epidemiology and Community Health, 64(1), 9. doi: 10.1136/jech.2009.100743 Wilson, H., & Thomson, G. (2010). The messy realities of smokefree policymaking to protect children. Dominion Post, 23 April, B7. Wilson, N., Baker, M., Jennings, L., Murdoch, D., Krause, K., Edwards, R., Roberts, M., Pearce, N., Douwes, J., Johnston, D., & Rice, G. (2009). A design fault in New Zealand’s health research funding system exposed by pandemic influenza [Letter]. New Zealand Medical Journal, 122(1304). Retrieved from http://www.nzma.org.nz/journal/122-1304/3839/ Wilson, N., Edwards, R., Thomson, G., Weerasekera, D., & Talemaitoga, A. (2010). High support for a tobacco endgame by Pacific peoples who smoke: National survey data [Letter]. New Zealand Medical Journal, 123(1316). Retrieved from http:// www.nzma.org.nz/journal/archive.php

Division of HEALTH SCIENCES 209 Commissioned Report for External Body Blakely, T., Shaw, C., Tobias, M., Sarfati, D., Cunningham, R., Atkinson, J., Bastiampillai, N., & Sloane, K. (2010). Cancer trends: Trends in incidence by ethnic and socioeconomic group, New Zealand 1981-2004. Wellington, New Zealand: University of Otago and the Ministry of Health, 236p. Collings, S. (2009). Who cares for people with schizophrenia: Family carers’ health, circumstances and adjustment [Blue Skies Report No. 28/09]. Commissioned by Families Commission. Wellington, New Zealand: Families Commission, 46p. Dowell, A. C., Garrett, S., Collings, S., McBain, L., McKinlay, E., & Stanley, J. (2009). Evaluation of the Primary Mental Health Initiatives: Summary report. Wellington, New Zealand: University of Otago and the Ministry of Health, 80p. Robson, B., Purdie, G., & Cormack, D. (2010). Unequal Impact II: Māori and Non-Māori cancer statistics by deprivation and rural-urban status 2002-2006. Wellington, New Zealand: Ministry of Health, 167p.

Working Paper; Discussion Paper; Technical Report Perera, R., Morris, C., & Dowell, T. (2010). Voyage to quality: Clinical indicator report. Royal New Zealand College of General Practitioners. Wellington, New Zealand: Primary Health Care Quality Research Unit, University of Otago. (pp. 1-165). Perera, R., Morris, C., & Dowell, T. (2010). Voyage to quality: Clinical indicator report [Interim Report No. 6]. Royal New Zealand College of General Practitioners. Wellington, New Zealand: Primary Health Care Quality Research Unit, University of Otago. (pp. 1-54). Perera, R., Morris, C., & Dowell, T. (2010). Voyage to quality: Quality framework report [Interim report]. Royal New Zealand College of General Practitioners. Wellington, New Zealand: Primary Health Care Quality Research Unit, University of Otago. (pp. 1-19). Perera, R., Morris, C., & Dowell, T. (2010). Voyage to quality: Summary of work (February 2009-August 2010). Royal New Zealand College of General Practitioners. Wellington, New Zealand: Primary Health Care Quality Research Unit, University of Otago. (pp. 1-39). Perera, R., Morris, C., Laidlaw, T., Litchfield, M., Du Jary, S., & Dowell, T. (2009). Voyage to quality: Mapping the quality landscape [Interim report]. Royal New Zealand College of General Practitioners. Wellington, New Zealand: Primary Health Care Quality Research Unit, University of Otago. (pp. 1-118).

University of Otago, Wellington DEPARTMENT OF RADIATION THERAPY

Chapter in Book - Research Maihoff, S. E., & Dungey, G. (2010). Patient assessment. In C. M. Washington & D. T. Leaver (Eds.), Principles and practice of radiation therapy (3rd revised ed.). (pp. 226-246). St Louis, MO: Elsevier Health Sciences.

Journal - Research Article Berridge, M. V., Herst, P. M., & Lawen, A. (2009). Targeting mitochondrial permeability in cancer drug development. Molecular Nutrition & Food Research, 53(1), 76-86. doi: 10.1002/mnfr.200700493 Berridge, M. V., Herst, P. M., & Tan, A. S. (2010). Metabolic flexibility and cell heirarchy in metastatic cancer. Mitochondrion, 10(6), 584-588. doi: 10.1016/j.mito.2010.08.002 Coleman, K., Herst, P., & Sycamore, C. (2009). Role extension for radiation therapists in New Zealand: A survey of radiation oncologists and radiation therapists. Shadows, 52(1), 11-18. Diggelmann, K. V., Zytkovicz, A. E., Tuaine, J. M., Bennett, N. C., Kelly, L. E., & Herst, P. M. (2010). Mepilex Lite dressings for the management of radiation-induced erythema: A systematic inpatient controlled clinical trial. British Journal of Radiology, 83(995), 971-978. doi: 10.1259/bjr/62011713 Dungey, G. M. (2009). What effect does treating cancer patients have on radiation therapy students’ identity development? The Radiographer, 56(1), 10-15. Herst, P. M., Davis, J. E., Neeson, P., Berridge, M. V., & Ritchie, D. S. (2009). The anti-cancer drug, phenoxodiol, kills primary myeloid and lymphoid leukemic blasts and rapidly proliferating T cells. Haematologica, 94(7), 928-934. doi: 10.3324/ haematol.2008.003996 Martin, W. J., Herst, P. M., Chia, E. W., & Harper, J. L. (2009). Sesquiterpene dialdehydes inhibit MSU crystal-induced superoxide production by infiltrating neutrophils in an in vivo model of gouty inflammation. Free Radical Biology and Medicine, 47(5), 616-621. doi: 10.1016/j.freeradbiomed.2009.05.035

210 RESEARCH REPORT 2009/2010 University of Otago, Wellington Department of Surgery and Anaesthesia

Journal - Research Article Brougham, N. D. L., Dennett, E. R., & Tan, S. T. (2010). Non-melanoma skin cancers in New Zealand: A neglected problem. New Zealand Medical Journal, 123(1325). Retrieved from http://www.nzma.org.nz/journal/123-1325/4421/content.pdf Calvert, G. T., Devane, P. A., Fielden, J., Adams, K., & Horne, J. G. (2009). A double-blind, prospective, randomized controlled trial comparing highly cross-linked and conventional polyethylene in primary total hip arthroplasty. Journal of Arthroplasty, 24(4), 505-510. doi: 10.1016/j.arth.2008.02.011 Cave, G., Harvey, M. G., & Winterbottom, T. (2009). Evaluation of the Association of Anaesthetists of Great Britain and Ireland lipid infusion protocol in bupivacaine induced cardiac arrest in rabbits. Anaesthesia, 64(7), 732-737. doi: 10.1111/j.1365-2044.2009.05893.x Cunningham, R., Sarfati, D., Hill, S., Dennett, E., & O’Donnell, A. (2009). Colon cancer management in New Zealand: 1996- 2003. New Zealand Medical Journal, 122(1294). Retrieved from http://www.nzma.org.nz/journal/122-1294/3581/ Elder, D. E., Campbell, A. J., Larsen, P. D., & Galletly, D. (2010). Respiratory variability in preterm and term infants: Effect of sleep state; position and age. Respiratory Physiology & Neurobiology, Advance Online Publication. doi: 10.1016/j. resp.2010.11.011 Elder, D. E., Larsen, P. D., Galletly, D. C., & Campbell, A. J. (2010). Cardioventilatory coupling in preterm and term infants: Effect of position and sleep state. Respiratory Physiology & Neurobiology, 174(1-2), 128-134. doi: 10.1016/j. resp.2010.05.012 Elder, D. E., Whale, J., Galletly, D., & Campbell, A. J. (2010). Respiratory events in preterm infants prior to discharge: With and without clinically concerning apnoea. Sleep and Breathing, Advance Online Publication. doi: 10.1007/s11325-010-0457-x Gatenby, P. A. C., & Bann, S. D. (2009). Antireflux surgery. Minerva Chirurgica, 64(2), 169-181. Harper, S. J., McEwen, A. R., & Dennett, E. R. (2010). Immunohistochemical testing for colon cancer: What do New Zealand surgeons know? New Zealand Medical Journal, 123(1325). Retrieved from http://www.nzma.org.nz/ journal/123-1325/4413/content.pdf Harvey, M., & Cave, G. (2010). A novel method to assist gastric tube insertion: A case series. Emergency Medicine Journal, 27(8), 613-615. doi: 10.1136/emj.2009.077404 Harvey, M., Cave, G., & Hoggett, K. (2009). Correlation of plasma and peritoneal diasylate clomipramine concentration with hemodynamic recovery after intralipid infusion in rabbits. Academic Emergency Medicine, 16(2), 151-156. doi: 10.1111/j.1553-2712.2008.00313.x Harvey, M., Cave, G., & Kazemi, A. (2009). Intralipid infusion diminishes return of spontaneous circulation after hypoxic cardiac arrest in rabbits. Anesthesia and Analgesia, 108(4), 1163-1168. doi: 10.1213/ane.0b013e31819367ba Hermiz, S., Larsen, P., Galletly, D. C., & Harding, S. A. (2009). Peri-operative management of anti-platelet agents. ANZ Journal of Surgery, 79(7-8), 521-525. doi: 10.1111/j.1445-2197.2009.04981.x Hill, S., Sarfati, D., Blakely, T., Robson, B., Purdie, G., Chen, J., Dennett, E., Cormack, D., Cunningham, R., Dew, K., McCreanor, T., & Kawachi, I. (2010). Survival disparities in indigenous and non-indigenous New Zealanders with colon cancer: The role of patient comorbidity, treatment and health service factors. Journal of Epidemiology and Community Health, 64(2), 117-123. doi: 10.1136/jech.2008.083816 Hill, S., Sarfati, D., Blakely, T., Robson, B., Purdie, G., Dennett, E., Cormack, D., Dew, K., Ayanian, J. Z., & Kawachi, I. (2010). Ethnicity and management of colon cancer in New zealand: Do indigenous patients get a worse deal? Cancer, 116(13), 3205-3214. doi: 10.1002/cncr.25127 Hingorani, R., & Swain, A. (2009). An unusual cause of lower abdominal pain in pubertal girls. Emergency Medicine Journal, 26(12), 909-910. doi: 10.1136/emj.2009.073601 Itinteang, T., Brasch, H. D., Tan, S. T., & Day, D. J. (2010). Expression of components of the renin—angiotensin system in proliferating infantile haemangioma may account for the propranolol-induced accelerated involution. Journal of Plastic, Reconstructive & Aesthetic Surgery, Advance Online Publication. doi: 10.1016/j.bjps.2010.08.039 Itinteang, T., Tan, S. T., Brasch, H., & Day, D. J. (2010). Haemogenic endothelium in infantile haemangioma. Journal of Clinical Pathology, 63(11), 982-986. doi: 10.1136/jcp.2010.081257 Itinteang, T., Tan, S. T., Brasch, H., & Day, D. J. (2010). Primitive mesodermal cells with a neural crest stem cell phenotype predominate proliferating infantile haemangioma. Journal of Clinical Pathology, 63(9), 771-776. doi: 10.1136/ jcp.2010.079368 Larsen, P. D., De Silva, P., Harding, S. A., Woodcock, E., & Lever, N. A. (2010). Use of implantable cardioverter defibrillators in the New Zealand context from 2000 to 2007. New Zealand Medical Journal, 123(1309). Retrieved from http://www.nzma. org.nz/journal/123-1309/3977/ Larsen, P. D., Tzeng, Y. C., Sin, P. Y. W., & Galletly, D. C. (2010). Respiratory sinus arrhythmia in conscious humans during spontaneous respiration. Respiratory Physiology & Neurobiology, Advance Online Publication. doi: 10.1016/j. resp.2010.04.021 Lever, N. A., Larsen, P. D., Dawes, M., Wong, A., & Harding, S. A. (2009). Are our medical graduates in New Zealand safe and accurate in ECG interpretation? New Zealand Medical Journal, 122(1292). Retrieved from http://www.nzma.org.nz/ journal/archive.shtml

Division of HEALTH SCIENCES 211 Lewis, N. C. S., Atkinson, G., Lucas, S. J. E., Grant, E. J. M., Jones, H., Tzeng, Y. C., Horsman, H., & Ainslie, P. N. (2010). Diurnal variation in time to presyncope and associated circulatory changes during a controlled orthostatic challenge. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 68(1), R55-R61. doi: 10.1152/ajpregu.00030.2010 Lucas, S. J. E., Tzeng, Y. C., Galvin, S. D., Thomas, K. N., Ogoh, S., & Ainslie, P. N. (2010). Influence of changes in blood pressure on cerebral perfusion and oxygenation. Hypertension, 55, 698-705. doi: 10.1161/ HYPERTENSIONAHA.109.146290 Marsland, C., Larsen, P., Segal, R., Hunter, S., Morris, J., et al. (2010). Proficient manipulation of fibreoptic bronchoscope to carina by novices on first clinical attempt after specialized bench practice. British Journal of Anaesthesia, 104(3), 375-381. doi: 10.1093/bja/aeq005 McHale, B., Harding, S. A., Larsen, P. D., & Lever, N. A. (2009). A national survey of clinician’s knowledge of and attitudes towards implantable cardioverter defibrillators. Europace, 11(10), 1313-1316. doi: 10.1093/europace/eup236 Memon, S., Keating, J. P., Cooke, H. S., & Dennett, E. R. (2009). A study into external rectal anatomy: Improving patient selection for radiotherapy for rectal cancer. Diseases of the Colon and Rectum, 52(1), 87-90. Mistry, R., Wademan, B., Avery, G., & Tan, S. T. (2010). A case of misdiagnosed squamous cell carcinoma due to alternative medical misadventure—time for tightening regulation? New Zealand Medical Journal, 123(1312). Retrieved from http:// www.nzma.org.nz/journal/123-1312/4056/ Ogoh, S., Tzeng, Y-C., Lucas, S. J. E., Galvin, S. D., & Ainslie, P. N. (2010). Influence of baroreflex-mediated tachycardia on the regulation of dynamic cerebral perfusion during acute hypotension in humans. Journal of Physiology, 588(2), 365-371. doi: 10.1113/jphysiol.2009.180844 Panfilov, I., Lever, N. A., Smaill, B. H., & Larsen, P. D. (2009). Ventricular fibrillation frequency from implanted cardioverter defibrillator devices. Europace, 11(8), 1052-1056. doi: 10.1093/europace/eup159 Rajaratnam, S. G., & Dennett, E. R. (2009). Development of metachronous neoplasms after colorectal cancer resection: Absence of synchronous neoplasms predicts a lower risk. New Zealand Medical Journal, 122(1294). Retrieved from http:// www.nzma.org.nz/journal/122-1294/3583/ Robinson, S., Swain, A. H., Hoyle, S. R., & Larsen, P. D. (2010). Survival from out-of-hospital cardiac arrest in New Zealand following the 2005 resuscitation guideline changes. Resuscitation, 81(12), 1648-1651. doi: 10.1016/j. resuscitation.2010.07.009 Sapre, N., Munting, K., Pandita, A., & Stubbs, R. (2009). Pregnancy following gastric bypass surgery: What is the expected course and outcome? New Zealand Medical Journal, 122(1306). Retrieved from http://www.nzma.org.nz/ journal/122-1306/3886/ Sarfati, D., Hill, S., Blakely, T., Robson, B., Purdie, G., Dennett, E., Cormack, D., & Dew, K. (2009). The effect of comorbidity on the use of adjuvant chemotherapy and survival from colon cancer: A retrospective cohort study. BMC Cancer, 9, 116. doi: 10.1186/1471-2407-9-116 Sarfati, D., Hill, S., Purdie, G., Dennett, E., & Blakely, T. (2010). How well does routine hospitalisation data capture information on comorbidity in New Zealand? New Zealand Medical Journal, 123(1310). Retrieved from http://www.nzma. org.nz/journal/123-1310/4010/ Sin, P. Y. W., Galletly, D. C., & Tzeng, Y. C. (2010). Influence of breathing frequency on the pattern of respiratory sinus arrhythmia and blood pressure: Old questions revisited. American Journal of Physiology Heart and Circulatory Physiology, 298, H1588-H1599. doi: 10.1152/ajpheart.00036.2010 Sin, P. Y. W., Webber, M. R., Galletly, D. C., Ainslie, P. N., Brown, S. J., Willie, C. K., Sasse, A., Larsen, P. D., & Tzeng, Y-C. (2010). Interactions between heart rate variability and pulmonary gas exchange efficiency in humans. Experimental Physiology, 95(7), 788-797. doi: 10.1113/expphysiol.2010.052910 Srinivasa, S., & Tan, S. T. (2010). Postoperative fluid management in major elective plastic surgery. Journal of Plastic Reconstructive and Aesthetic Surgery, 63(6), 992-995. doi: 10.1016/j.bjps.2009.02.084 Sud, A. R., & Tan, S. T. (2010). Pyogenic granuloma: Treatment by shave-excision and/or pulsed-dye laser. Journal of Plastic Reconstructive and Aesthetic Surgery, 63(8), 1364-1368. doi: 10.1016/j.bjps.2009.06.031 Tan, S. T., Itinteang, T., & Leadbitter, P. (2010). Low-dose propranolol for infantile haemangioma. Journal of Plastic, Reconstructive & Aesthetic Surgery, Advance Online Publication. doi: 10.1016/j.bjps.2010.06.010 Tzeng, Y-C., Lucas, S. J. E., Atkinson, G., Willie, C. K., & Ainslie, P. N. (2010). Fundamental relationships between arterial baroreflex sensitivity and dynamic cerebral autoregulation in humans. Journal of Applied Physiology, 108, 1162-1168. doi: 10.1152/japplphysiol.01390.2009 Tzeng, Y-C., Sin, P. Y. W., & Galletly, D. C. (2009). Human sinus arrhythmia: Inconsistencies of a teleological hypothesis. American Journal of Physiology: Heart and Circulatory Physiology, 296(1), H65-H70. doi: 10.1152/ajpheart.00716.2008 Tzeng, Y. C., Sin, P. Y. W., Lucas, S. J. E., & Ainslie, P. N. (2009). Respiratory modulation of cardio-vagal baroreflex sensitivity. Journal of Applied Physiology, 107, 718-724. doi: 10.1152/japplphysiol.00548.2009 Tzeng, Y-C., Willie, C. K., Atkinson, G., Lucas, S. J. E., Wong, A., & Ainslie, P. N. (2010). Cerebrovascular regulation during transient hypotension and hypertension in humans. Hypertension, 56, 268-273. doi: 10.1161/ HYPERTENSIONAHA.110.152066 Visser, A., FitzJohn, T., & Tan, S. T. (2010). Surgical management of arteriovenous malformation. Journal of Plastic, Reconstructive & Aesthetic Surgery, Advance Online Publication. doi: 10.1016/j.bjps.2010.05.033 Wilkinson, T. J., Weller, J. M., McKimm, J., O’Connor, B. J., ..., Tweed, M. J., & Wearn, A. M. (2010). Programmatic research in New Zealand medical education: A national collaboration. New Zealand Medical Journal, 123(1318). Retrieved from http://www.nzma.org.nz/journal/123-1318/4210/

212 RESEARCH REPORT 2009/2010 Journal - Research Other Ainslie, P. N., & Tzeng, Y. C. (2010). On the regulation of the blood supply to the brain: Old age concepts and new age ideas [Invited editorial]. Journal of Applied Physiology, 108(6), 1447-1449. doi: 10.1152/japplphysiol.00257.2010 Ainslie, P. N., Willie, C. K., & Tzeng, Y. C. (2009). Role of SNA in the pathophysiology of cardiovascular collapse during syncope: Muscle vs. Brain [Letter]. Journal of Physiology, 587(23), 5795-5796. doi: 10.1113/jphysiol.2009.182667 Cave, G., & Harvey, M. (2009). Lipid emulsion may augment early blood pressure recovering in a rabbit model of atenolol toxicity. Journal of Medical Toxicology, 5(1), 50-51. Foo, J., Toomath, R., Wickremesekera, S. K., Bann, S., & Stubbs, R. (2010). Bariatric surgery: A dilemma for the health system? [Editorial]. New Zealand Medical Journal, 123(1311). Retrieved from http://www.nzmj.org/journal/123-1311/ Low, I., Ch’ng, S., Ng, D., Sullivan, M., Brasch, H., Davis, P., & Tan, S. T. (2009). HER2 polysomy in aggresive head and neck cutaneous squamous cell carcinoma [Correspondence]. Human Pathology, 40(6), 902-903. doi: 10.1016/j. humpath.2008.12.012 Lucas, S. J. E., Tzeng, Y. C., & Ainslie, P. N. (2010). Response to The cerebrovascular pressure-flow relationship: A simple concept but a complex phenomenon [Letter]. Hypertension, 56, e3. doi: 10.1161/HYPERTENSIONAHA.110.153312 Thurston, A. J. (2009). Art of preserving health: Studies on the medical supervision of physical exercise. ANZ Journal of Surgery, 79(12), 941-945. Tweed, M. J., Bagg, W., Child, S., Wilkinson, T. J., & Weller, J. M. (2010). How the trainee intern (TI) year can ease the transition from undergraduate education to postgraduate practice. New Zealand Medical Journal, 123(1318). Retrieved from http://www.nzma.org.nz/journal/archive.php Tzeng, S. Y. C., Sin, P. Y. W., & Ainslie, P. N. (2009). Sinus arrhythmia and baroreflex sensitivity: Intimate relationship or separate identities? [Letter to the editor]. Journal of Applied Physiology, 106(5), 1745-1746. Tzeng, Y. C., Willie, C. K., & Ainslie, P. N. (2010). Baroreflex, cerebral perfusion, and stroke: Integrative physiology at its best [Letter to the editor]. Stroke, Advance Online Publication. doi: 10.1161/STROKEAHA.109.570853

Journal - Professional & Other Non-Research Articles Laing, R., & Tan, S. T. (2009). Pretibial injury: Prevention is possible and preferable [Letter]. New Zealand Medical Journal, 122(1291). Retrieved from http://www.nzma.org.nz/journal/archive.shtml Swain, A. H., Hoyle, S. R., & Long, A. W. (2010). The changing face of prehospital care in New Zealand: The role of extended care paramedics [Editorial]. New Zealand Medical Journal, 123(1309). Retrieved from http://www.nzma.org.nz/ journal/123-1309/3985/ Thurston, A. J. (2009). Ætiology of extraosseous wrist ganglia: The published evidence. Orthopaedics and Trauma, 23(3), 186- 188. doi: 10.1016/j.mporth.2009.01.001 Willie, C. K., & Tzeng, Y. C. (2010). Study of the heterogeneity of cardiovascular function should extend to the human cerebral circulation [Letter]. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 298(6), R1705. doi: 10.1152/ajpregu.00166.2010

University of Otago, Christchurch DEAN’S DEPARTMENT

Authored Book - Research Cave, T., Robertson, P., Pitama, S., & Huriwai, T. (2009). He tete kura: Maori addiction treatment: 1980-2008. Wellington, New Zealand: Matua Raki, 203p.

Journal - Research Article Bergin, M., Bird, P., Cowan, I., & Pearson, J. F. (2010). Exploring the critical distance and position relationships between the eustachian tube and the internal carotid artery. Otology & Neurotology, Advance Online Publication. doi: 10.1097/ MAO.0b013e3181f6c880 Berry, S. D., Davis, S. R., Beattie, E. M., ..., Pearson, J. F., et al. (2009). Mutation in bovine &beta-carotene oxygenase 2 affects milk color. Genetics, 182, 923-926. doi: 10.1534/genetics.109.101741 Heenan, P. B., Mitchell, A. D., de Lange, P. J., Keeling, J., & Paterson, A. M. (2010). Late-cenozoic origin and diversification of chatham islands endemic plant species revealed by analyses of DNA sequence data. New Zealand Journal of Botany, 48(2), 83-136. doi: 10.1080/0028825x.2010.494337 Jones, R., Pitama, S., Huria, T., Poole, P., McKimm, J., Pinnock, R., & Reid, P. (2010). Medical education to improve Mäori health. New Zealand Medical Journal, 123(1316). Retrieved from http://www.nzma.org.nz/journal/archive.php Lacey, C. J., Salzberg, M. R., Roberts, H., Trauer, T., & D’Souza, W. J. (2009). Psychiatric comorbidity and impact on health service utilization in a community sample of patients with epilepsy. Epilepsia, 50(8), 1991-1994. doi: 10.1111/j.1528- 1167.2009.02165.x Miller, A., Rudland, J., Hurrell, M., & Ali, A. (2009). Rad-Path: Integrated anatomical pathology and radiology undergraduate tutorials. Pathology, 41(5), 460-466. doi: 10.1080/00313020903049286

Division of HEALTH SCIENCES 213 Scott-Thomas, A. J., Syhre, M., Pattemore, P. K., Epton, M., Laing, R., Pearson, J., & Chambers, S. T. (2010). 2-Aminoacetophenone as a potential breath biomarker for Pseudomonas aeruginosa in the cystic fibrosis lung. BMC Pulmonary Medicine, 10, 56. Retrieved from http://www.biomedcentral.com/1471-2466/10/56 Spittlehouse, J. K., Pearson, J. F., Luty, S. E., Mulder, R. T., Carter, J. D., McKenzie, J. M., & Joyce, P. R. (2010). Measures of temperament and character are differentially impacted on by depression severity. Journal of Affective Disorders, 126, 140- 146. doi: 10.1016/j.jad.2010.03.010 Taylor, B. V., Pearson, J. F., Clarke, G., Mason, D. F., Abernethy, D. A., Willoughby, E., & Sabel, C. (2010). MS prevalence in New Zealand, an ethnically and latitudinally diverse country. Multiple Sclerosis, 16(12), 1422-1431. doi: 10.1177/1352458510379614 van Dalen, C. J., Aldridge, R. E., Chan, T., Senthilmohan, R., Hancox, R. J., Cowan, J. O., Taylor, D. R., Town, G. I., & Kettle, A. J. (2009). Bromotyrosines in sputum proteins and treatment effects of terbutaline and budesonide in asthma. Annals of Allergy Asthma & Immunology, 103(4), 348-353. Whitehead, C., Lunt, H., Pearson, J. F., & Cawood, T. J. (2010). Is screening for hypothyroidism in the diabetes clinic effective? Practical Diabetes International, 27(3), 113-117. doi: 10.1002/pdi.1458

Journal - Research Other Bridgman, P. G., & Ali, A. (2009). Leap of faith: From knowledge to safe practice [Editorial]. New Zealand Medical Journal, 122(1292).

University of Otago, Christchurch Department of Anaesthesia

Authored Book - Other Beard, M., Thwaites, J., Colls, B., Frazer, G., Jeffery, M., King, S., Menzies, O., Metcalf, S., Richards, D., Sidwell, A., & Young, M. L. (2009). Management guidelines for common medical conditions (13th ed.). Christchurch, New Zealand: Canterbury District Health Board, 290p.

Chapter in Book - Research Shipton, E. A. (2010). Pharmacogenomics and acute pain. In P. E. Mcintyre, D. A. Scott, S. A. Schug, E. J. Visser, & S. M. Walker (Eds.), Acute pain management: Scientific evidence (3rd ed.). (pp. 21-34). Melbourne, Australia: ANZCA & FPM.

Journal - Research Article Kennedy, R., Lee, A., & Frizelle, F. A. (2010). Influence of general health and degree of surgical insult on long-term survival. British Journal of Surgery, 97, 782-788. doi: 10.1002/bjs.6960 Kennedy, R. R., McKellow, M. A., & French, R. A. (2010). The effect of predictive display on the control of step changes in effect site sevoflurane levels. Anaesthesia, 65, 826-830. doi: 10.1111/j.1365-2044.2010.06410.x Kennedy, R. R., Merry, A. F., Warman, G. R., & Webster, C. S. (2009). The influence of various graphical and numeric trend display formats on the detection of simulated changes. Anaesthesia, 64(11), 1186-1191. doi: 10.1111/j.1365- 2044.2009.06082.x Lees, G., & Shipton, E. (2009). Voltage-gated sodium channels in nociception and their potential as targets for new drugs in treatment of chronic neuropathic pain. Current Anaesthesia and Critical Care, 20(5-6), 204-208. doi: 10.1016/j. cacc.2009.06.002 Ongley, D., & Shipton, E. (2010). Pain images: Hip pain-wrong diagnosis, wrong operation. Pain Medicine, 11, 942-945. doi: 10.1111/j.1526-4637.2010.00834.x Reith, D., Medlicott, N. J., Kumara De Silva, R., Yang, L., Hickling, J., & Zacharias, M. (2009). Simultaneous modelling of the Michaelis-Menten kinetics of paracetamol sulphation and glucuronidation. Clinical and Experimental Pharmacology and Physiology, 36(1), 35-42. doi: 10.1111/j.1440-1681.2008.05029.x Sakowska, M., Docherty, E., Linscott, D., & Connor, S. (2009). A change in practice from epidural to intrathecal morphine analgesia for hepato-pancreato-biliary surgery. World Journal of Surgery, 33(9), 1802-1808. doi: 10.1007/s00268-009-0131-2 Shipton, E. A. (2009). Complex regional pain syndrome - mechanisms, diagnosis, and management. Current Anaesthesia and Critical Care, 20(5-6), 209-214. doi: 10.1016/j.cacc.2009.07.012

Journal - Research Other Fredrickson, M. J., & Kennedy, R. R. (2010). Regional anaesthesia and pain relief after surgery [Editorial]. New Zealand Medical Journal, 123(1324). Retrieved from http://www.nzma.org.nz/journal/123-1324/4384/content.pdf Kennedy, R. R. (2010). Seeing the future of anesthesia drug dosing: Moving the art of anesthesia from impressionism to realism [Editorial]. Anesthesia and Analgesia, 111(2), 252-255. doi: 10.1213/ANE.0b013e3181e62ff1

214 RESEARCH REPORT 2009/2010 University of Otago, Christchucrh Department of Medicine

Authored Book - Other Beard, M., Thwaites, J., Colls, B., Frazer, G., Jeffery, M., King, S., Menzies, O., Metcalf, S., Richards, D., Sidwell, A., & Young, M. L. (2009). Management guidelines for common medical conditions (13th ed.). Christchurch, New Zealand: Canterbury District Health Board, 290p.

Chapter in Book - Research Richards, A. M. (2009). What we may expect from biomarkers in heart failure. In E. Braunwald (Ed.), Biomarkers in heart failure: An issue of heart failure clinics (Vol.5-4) (pp. 463-470). Philadelphia, PA: Saunders. doi: 10.1016/j.hfc.2009.04.011 Troughton, R. W. (2010). Dilated cardiomyopathy. In M. J. Garcia (Ed.), Noninvasive cardiovascular imaging: A multimodality approach (pp. 465-477). Philadelphia, PA: Lippincott Williams & Wilkins.

Chapter in Book - Other Rademaker, M. T., & Espiner, E. (2010). Hormones of the cardiovascular system. In J. L. Jameson & L. J. De Groot (Eds.), Endocrinology: Adult and pediatric (Vol. II) (6 ed.). (pp. 2036-2052). Philadelphia, PA: Saunders. Stedman, C. A. M., Downes, M., & Liddle, C. (2010). Signaling pathways in liver disease: PXR and CAR. In J-F. Dufour & P-A. Clavien (Eds.), Signaling pathways in liver disease (2nd ed.). (pp. 333-343). Berlin: Springer-Verlag. doi: 10.1007/978-3- 642-00150-5_22 Wilkinson, T. (2010). Communicating with older people. In M. Groves & J. Fitzgerald (Eds.), Communication skills in medicine: Promoting patient-centred care (pp. 146-158). Victoria, Australia: IP Communications.

Journal - Research Article Allardyce, R. A., Bagshaw, P. F., Frampton, C. M., Frizelle, F. A., Hewett, P. J., Rieger, N. A., Smith, J. S., Solomon, M. J., Stevenson, A. R. L., & Australasian Laparoscopic Colon Cancer Study Group (2010). Australasian Laparoscopic Colon Cancer Study shows that elderly patients may benefit from lower postoperative complication rates following laparoscopic versus open resection. British Journal of Surgery, 97, 86-91. doi: 10.1002/bjs.6785 Amir, N. L., Gerber, I. L., Edmond, J. J., Langlands, J. M., Richards, A. M., & Ruygrok, P. N. (2009). Plasma B-type natriuretic peptide levels in cardiac donors. Clinical Transplantation, 23, 174-177. doi: 10.1111/j.1399-0012.2009.00954.x Amodeo, M. R., Clulow, T., Lainchbury, J., Murdoch, D. R., Gallagher, K., Dyer, A., Metcalf, S. L., Pithie, A. D., & Chambers, S. T. (2009). Outpatient intravenous treatment for infective endocarditis: Safety, effectiveness and one-year outcomes. Journal of Infection, 59(6), 387-393. doi: 10.1016/j.jinf.2009.09.009 Anderson, N. E., Somaratne, J., Mason, D. F., Holland, D., & Thomas, M. G. (2010). A review of tuberculous meningitis at Auckland City Hospital, New Zealand. Journal of Clinical Neuroscience, 17, 1018-1022. doi: 10.1016/j.jocn.2010.01.007 Anderson, N. E., Somaratne, J., Mason, D. F., Holland, D., & Thomas, M. G. (2010). Neurological and systemic complications of tuberculous meningitis and its treatment at Auckland City Hospital, New Zealand. Journal of Clinical Neuroscience, 17, 1114-1118. doi: 10.1016/j.jocn.2010.01.006 Anderson, N. G., Butler, A. P., Scott, N. J. A., Cook, N. J., Butzer, J. S., Schleich, N., et al. (2010). Spectroscopic (multi-energy) CT distinguishes iodine and barium contrast material in MICE. European Radiology, 20, 2126-2134. doi: 10.1007/s00330- 010-1768-9 Anderson, N. G., Fischer, J., Leighton, D., Hector-Taylor, J., & McEwing, R. L. (2010). Management in children of mild postnatal renal dilatation but without vesicoureteral reflux. Pediatric Nephrology, 25(3), 477-843. doi: 10.1007/s00467-009- 1348-x Appelhoff, R. J., Hill, J. V., Findon, G., Frampton, C. M., Perry, E., Ponnamperuma, D., & Endre, Z. H. (2010). Differential contribution of diabetes and the Ren2 gene to glomerular pathology in diabetic (mREN-2)27 rats. Laboratory Investigation, 90, 1225-1235. doi: 10.1038/labinvest.2010.96 Avouac, J., Walker, U., Tyndall, A., Kahan, A., Matucci-Cerrinic, M., Allanore, Y., EUSTAR, including Stebbings, S., & Stamp, L. (2010). Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis: Results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database. Journal of Rheumatology, 37(7), 1488-1501. doi: 10.3899/jrheum.091165 Bagshaw, P. F., Allardyce, R. A., Bagshaw, S. N., Stokes, B. W., Shaw, C. S., Proffit, L. J., Nicholls, M. G., Begg, E. J., & Frampton, C. M. (2010). Patients “falling through the cracks”. The Canterbury Charity Hospital: Initial progress report. New Zealand Medical Journal, 123(1320). Retrieved from http://www.nzma.org.nz/journal/archive.php Bardy, G. H., Smith, W. M., Hood, M. A., Crozier, I. G., Melton, I. C., Jordaens, L., Theuns, D., Park, R. E., et al. (2010). An entirely subcutaneous implantable cardioverter-defibrillator. New England Journal of Medicine, 363(1), 36-44. doi: 10.1056/ NEJMoa0909545 Barnett, R., Pearce, J., Moon, G., Elliott, J., & Barnett, P. (2009). Assessing the effects of the introduction of the New Zealand Smokefree Environment Act 2003 on acute myocardial infarction hospital admissions in Christchurch, New Zealand. Australian and New Zealand Journal of Public Health, 33(6), 515-520. doi: 10.1111/j.1753-6405.2009.00446.x Begg, E. J., Vella-Brincat, J. W. A., Robertshawe, B., McMurtrie, M. J., Kirkpatrick, C. M. J., & Darlow, B. (2009). Eight years’ experience of an extended-interval dosing protocol for gentamicin in neonates. Journal of Antimicrobial Chemotherapy, 63, 1043-1049. doi: 10.1093/jac/dkp073

Division of HEALTH SCIENCES 215 Bell, C., Bourke, C., Colhoun, H., Carter, F., Frampton, C., & Porter, R. (2010). The misclassification of facial expressions in generalised social phobia. Journal of Anxiety Disorders, Advance Online Publication. doi: 10.1016/j.janxdis.2010.10.001 Bentley, R. W., Cleynen, I., Gearry, R. B., Barclay, M. L., Rutgeerts, P., Merriman, T. R., Ferrante, M., Roberts, R. L., & Vermeire, S. (2010). Evidence that glioma-associated oncogene homolog 1 is not a universal risk gene for inflammatory bowel disease in Caucasians. Genes & Immunity, Advance Online Publication. doi: 10.1038/gene.2010.15 Bentley, R. W., Pearson, J., Gearry, R. B., Barclay, M. L., McKinney, C., Merriman, T. R., & Roberts, R. L. (2010). Association of higher DEFB4 genomic copy number with Crohn’s disease. American Journal of Gastroenterology, 105(2), 354-359. doi: 10.1038/ajg.2009.582 Bonke, G., & Jensen, B. P. (2010). Fast and sensitive LC-MS/MS assay for quantification of nortriptyline and its active metabolites E- and Z-10-hydroxynortriptyline in human plasma. Bioanalysis, 2(9), 1553-1560. doi: 10.4155/bio.10.89 Brownlie, B. E. W., Hunt, P. J., & Turner, J. G. (2010). Juvenile thyrotoxicosis: A South Island, New Zealand experience with long-term outcome. New Zealand Medical Journal, 123(1313). Retrieved from http://www.nzma.org.nz/ journal/123-1313/4084/content.pdf Butler, A. P. H., Butzer, J., Schleich, N., Cook, N. J., Anderson, N. G., Scott, N., de Ruiter, N., Grasset, R., Tlustos, L., & Butler, P. H. (2010). Processing of spectral X-ray data with principal components analysis. Nuclear Instruments and Methods in Physics Research A, Advance Online Publication. doi: 10.1016/j.nima.2010.06.149 Camargo, Jr, C. A., Ingham, T., Wickens, K., Thadhani, R. I., Silvers, K. M., Epton, M. J., Town, G. I., Espinola, J. A., Crane, J., & New Zealand Asthma and Allergy Cohort Study Group (2010). Vitamin D status of newborns in New Zealand. British Journal of Nutrition, 104(7), 1051-1057. doi: 10.1017/S0007114510001674 Carter, J. D., Frampton, C. M. A., Mulder, R. T., Luty, S. E., McKenzie, J. M., & Joyce, P. R. (2009). Rumination: Relationship to depression and personality in a clinical sample. Personality and Mental Health, 3, 275-283. doi: 10.1002/pmh.91 Carter, J. D., Frampton, C. M., Mulder, R. T., Luty, S. E., & Joyce, P. R. (2010). The relationship of demographic, clinical, cognitive and personality variables to the discrepancy between self and clinician rated depression. Journal of Affective Disorders, 124(1-2), 202-206. doi: 10.1016/j.jad.2009.11.011 Carter, J. D., Luty, S. E., McKenzie, J. M., Mulder, R. T., Frampton, C. M., & Joyce, P. R. (2010). Patient predictors of response to cognitive behaviour therapy and interpersonal psychotherapy in a randomised clinical trial for depression. Journal of Affective Disorders, Advance Online Publication. doi: 10.1016/j.jad.2010.07.002 Cawood, T. J., Bashir, M., Brady, J., Murray, B., Murray, P. T., & O’Shea, D. (2010). Urinary collagen IV and pGST: Potential biomarkers for detecting localized kidney injury in diabetes: A pilot study. American Journal of Nephrology, 32(3), 219-225. doi: 10.1159/000317531 Cawood, T. J., Hunt, P. J., O’Shea, D., Cole, D., & Soule, S. (2009). Recommended evaluation of adrenal incidentalomas is costly, has high false-positive rates and confers a risk of fatal cancer that is similar to the risk of the adrenal lesion becoming malignant: Time for a rethink? European Journal of Endocrinology, 161(4), 513-527. doi: 10.1530/EJE-09-0234 Chambers, S. T., Syhre, M., Murdoch, D. R., McCartin, F. J., & Epton, M. J. (2009). Detection of 2-Pentylfuran in the breath of patients with Aspergillus fumigatus. Medical Mycology, 47(5), 468-476. doi: 10.1080/13693780802475212 Chan, W., Campbell, T., MacDonald, S., & Crozier, I. (2010). Christchurch experience of pulmonary embolism with and without thrombolysis. New Zealand Medical Journal, 123(1324). Retrieved from http://www.nzma.org.nz/ journal/123-1324/4381/content.pdf Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2010). Urocortin 2 induces potent long-lasting inhibition of cardiac sympathetic drive despite baroreflex activation in conscious sheep. Journal of Endocrinology, 204, 181-189. doi: 10.1677/JOE-08-0505 Charles, C. J., Rademaker, M. T., Nicholls, M. G., & Richards, A. M. (2010). Adrenomedullin 2 attenuates the pressor but not adrenal responses to angiotensin II in conscious sheep. Peptides, 31, 878-882. doi: 10.1016/j.peptides.2010.02.010 Chase, J. G., Andreassen, S., Pielmeier, U., Hann, C. E., McAuley, K. A., & Mann, J. I. (2009). A glucose-insulin pharmacodynamic surface modeling validation and comparison of metabolic system models. Biomedical Signal Processing and Control, 4(4), 355-363. doi: 10.1016/j.bspc.2009.04.002 Chase, J. G., Mayntzhusen, K., Docherty, P. D., Andreassen, S., McAuley, K. A., Lotz, T. F., & Hann, C. E. (2010). A three- compartment model of the C-peptide-insulin dynamic during the DIST test. Mathematical Biosciences, Advance Online Publication. doi: 10.1016/j.mbs.2010.09.001 Chen, Y-H., Yandle, T. G., Richards, A. M., & Palmer, S. C. (2009). Urotensin II immunoreactivity in the human circulation: Evidence for widespread tissue release. Clinical Chemistry, 55(11), 2040-2048. doi: 10.1373/clinchem.2009.131748 Chey, M. H., Rodgers, G. W., Chase, J. G., & Mander, J. B. (2010). Using upper storeys as semi-active tuned mass damper building systems: A case study analysis. Bulletin of the New Zealand Society for Earthquake Engineering, 43(2), 126-133. Chin, P. K. L., Beckert, L. E. L., Gunningham, S., Edwards, A. L., & Robinson, B. A. (2009). Audit of anticoagulant thromboprophylaxis in hospitalized oncology patients. Internal Medicine Journal, 39(12), 819-825. doi: 10.1111/j.1445- 5994.2008.01828.x Choo, A. L., Robb, M. P., Dalrymple-Alford, J. C., Huckabee, M-L., & O’Beirne, G. A. (2010). Different lip asymmetry in adults who stutter: Electromyographic evidence during speech and non-speech. Folia Phoniatrica Et Logopaedica, 62(3), 143-147. doi: 10.1159/000287213 Cooper, G. J. S., Young, A. A., Gamble, G. D., ..., Frampton, C. M., Poppitt, S. D., & Doughty, R. N. (2009). A copper(II)- selective chelator ameliorates left-ventricular hypertrophy in type 2 diabetic patients: A randomised placebo-controlled study. Diabetologia, 52(4), 715-722. doi: 10.1007/s00125-009-1265-3

216 RESEARCH REPORT 2009/2010 Cullen, L., Than, M., Brown, A. F. T., Richards, M., et al. (2010). Comprehensive standardized data definitions for acute coronary syndrome research in emergency departments in Australasia. Emergency Medicine Australasia, 22(1), 35-55. doi: 10.1111/j.1742-6723.2010.01256.x Dachs, G. U., Kano, M., Volkova, E., Morrin, H. R., Davey, V. C. L., Harris, G. C., Cheale, M., Frampton, C., Currie, M. J., Wells, J. E., & Robinson, B. A. (2010). A profile of prognostic and molecular factors in European and Mäori breast cancer patients. BMC Cancer, 10, 543. Retrieved from http://www.biomedcentral.com/1471-2407/10/543 Dalrymple-Alford, J. C., MacAskill, M. R., Nakas, C. T., Livingston, L., Graham, C., Crucian, G. P., Melzer, T. R., Kirwan, J., Keenan, R., Wells, S., Porter, R. J., Watts, R., & Anderson, T. J. (2010). The MoCA: Well-suited screen for cognitive impairment in Parkinson disease. Neurology, 75(19), 1717-1725. doi: 10.1212/WNL.0b013e3181fc29c9 Dare, A., Fancourt, N., Robinson, E., Wilkinson, T., & Bagg, W. (2009). Training the intern: The value of a pre-intern year in preparing students for practice. Medical Teacher, 31(8), e345-e350. doi: 10.1080/01421590903127669 Davidson, P. J., Sheerin, I. G., & Frampton, C. (2009). Renal stone disease in Christchurch, New Zealand: Part 1: Presentation and epidemiology. New Zealand Medical Journal, 122(1297). Retrieved from http://www.nzma.org.nz/ journal/122-1297/3659/ Davidson, P. J., Sheerin, I. G., & Frampton, C. (2009). Renal stone disease in Christchurch, New Zealand: Part 2: A community study on the burden of renal stone disease. New Zealand Medical Journal, 122(1297). Retrieved from http://www.nzma. org.nz/journal/122-1297/3660/ Day, A. S., & Gearry, R. B. (2010). Rifaximin and Crohn’s disease: A new solution to an old problem? Digestive Diseases and Sciences, 55, 877-879. doi: 10.1007/s10620-010-1140-6 De Silva, D. A., Fink, J. N., Christensen, S., Ebinger, M., Bladin, C., Levi, C. R., et al, & EPITHET Investigators (2009). Assessing reperfusion and recanalization as markers of clinical outcomes after intravenous thrombolysis in the echoplanar imaging thrombolytic evaluation trial (EPITHET). Stroke, 40(8), 2872-2874. doi: 10.1161/STROKEAHA.108.543595 Docherty, P. D., Chase, J. G., Lotz, T. F., Hann, C. E., Shaw, G. M., Berkeley, J. E., TeMorenga, L., Mann, J. I., & McAuley, K. (2010). Independent cohort cross-validation of the real-time DISTq estimation of insulin sensitivity. Computer Methods and Programs in Biomedicine, Advance Online Publication. doi: 10.1016/j.cmpb.2010.08.002 Doogue, M. P., Begg, E. J., Moore, M. P., Lunt, H., Pemberton, C. J., & Zhang, M. (2009). Metformin increases plasma ghrelin in Type 2 diabetes. British Journal of Clinical Pharmacology, 68(6), 875-882. doi: 10.1111/j.1365-2125.2009.03372.x Dowson, C. A., Kuijer, R. G., Town, I. G., & Mulder, R. T. (2010). Impact of panic disorder upon self-management educational goals in chronic obstructive pulmonary disease? Chronic Respiratory Disease, 7(2), 83-90. doi: 10.1177/1479972310365363 Dummer, J. F., Epton, M. J., Cowan, J. O., Cook, J. M., Condliffe, R., Landhuis, C. E., Smith, A. D., & Taylor, D. R. (2009). Predicting corticosteroid response in chronic obstructive pulmonary disease using exhaled nitric oxide. American Journal of Respiratory and Critical Care Medicine, 180(9), 846-852. doi: 10.1164/rccm.200905-0685OC Dummer, J. F., ..., Frampton, C. M., Scotter, J. M., Prisk, G., & Epton, M. J. (2010). Accurate, reproducible measurement of acetone concentration in breath using selected ion flow tube-mass spectrometry. Journal of Breath Research, 4, 046001. doi: 10.1088/1752-7155/4/4/046001 Dunn, J. A., Hay-Smith, E. J. C., Whitehead, L. C., Keeling, S., & Rothwell, A. G. (2010). Upper limb reconstructive surgery uptake for persons with tetraplegia in New Zealand: A retrospective case review 2001-2005. Spinal Cord, Advance Online Publication. doi: 10.1038/sc.2010.15 Eglinton, T., Reilly, M., Chang, C., Barclay, M., Frizelle, F., & Gearry, R. (2010). Ileal disease is associated with surgery for perianal disease in a population-based Crohn’s disease cohort. British Journal of Surgery, 97(7), 1103-1109. doi: 10.1002/ bjs.7031 Eglinton, T. W., & Gearry, R. B. (2010). Clinical factors predicting disease course in Crohn’s disease. Expert Review of Clinical Immunology, 6(1), 41-45. doi: 10.1586/eci.09.76 Ellis, C., Devlin, G., Elliott, J., Matsis, P., Williams, M., Gamble, G., Hamer, A., Richards, M., et al. (2010). ACS patients in New Zealand experience significant delays to access cardiac investigations and revascularisation treatment especially when admitted to non-interventional centres: Results of the second comprehensive national audit of ACS patients. New Zealand Medical Journal, 123(1319). Retrieved from http://www.nzma.org.nz/journal/archive.php Ellis, C., Gamble, G., Hamer, A., ..., Elliott, J., Richards, M., et al. (2010). Patients admitted with an acute coronary syndrome in New Zealand in 2007: Results of a second comprehensive nationwide audit and a comparison with the first audit from 2002. New Zealand Medical Journal, 123(1319). Retrieved from http://www.nzma.org.nz/journal/archive.php Ellis, E., Ballance, K., Lunt, H., & Lewis, D. (2010). Diabetes outpatient care before and after admission for diabetic foot complications. Journal of Wound Care, 19(4), 150-152. Ellis, K. L., Pilbrow, A. P., Frampton, C. M., Doughty, R. N., Whalley, G. A., Ellis, C. J., Palmer, B. R., Skelton, L., Yandle, T. G., Palmer, S. C., Troughton, R. W., Richards, A. M., & Cameron, V. A. (2010). A common variant at chromosome 9P21.3 is associated with age of onset of coronary disease but not subsequent mortality. Circulation: Cardiovascular Genetics, 3(3), 286-293. doi: 10.1161/circgenetics.109.917443 Elmslie, J. L., Porter, R. J., Joyce, P. R., Hunt, P. J., Shand, B. I., & Scott, R. S. (2009). Comparison of insulin resistance, metabolic syndrome and adiponectin in overweight bipolar patients taking sodium valproate and controls. Australian and New Zealand Journal of Psychiatry, 43(1), 53-60. doi: 10.1080/00048670802534341 Endre, Z. H., & Pickering, J. W. (2010). Outcome definitions in non-dialysis intervention and prevention trials in acute kidney injury (AKI). Nephrology Dialysis Transplantation, 25(1), 107-118. doi: 10.1093/ndt/gfp501 Endre, Z. H., Pickering, J. W., Storer, M. K., Hu, W-P., Moorhead, K. T., Allardyce, R., McGregor, D. O., & Scotter, J. M. (2010). Breath ammonia and trimethylamine allow real-time monitoring of haemodialysis efficacy. Physiological Measurement, 32(1), 115-130. doi: 10.1088/0967-3334/32/1/008

Division of HEALTH SCIENCES 217 Endre, Z. H., Walker, R. J., Pickering, J. W., Shaw, G. M., Frampton, C. M., Henderson, S. J., Hutchinson, R., Mehrtens, J. E., Robinson, J. M., Schollum, J. B. W., Westhuyzen, J., Celi, L. A., McGinley, R. J., Campbell, I. J., & George, P. M. (2010). Early intervention with erythropoietin does not affect the outcome of acute kidney injury (the EARLYARF trial). Kidney International, 77, 1020-1030. doi: 10.1038/ki.2010.25 Epelman, S., Shrestha, K., Troughton, R. W., Francis, G. S., Sen, S., Klein, A. L., & Tang, W. H. W. (2009). Soluble angiotensin- converting enzyme 2 in human heart failure: Relation with myocardial function and clinical outcomes. Journal of Cardiac Failure, 15(7), 565-571. doi: 10.1016/j.cardfail.2009.01.014 Epton, M. J., Ledingham, K., Dummer, J., Hu, W-P., Rhodes, B., Senthilmohan, S. T., Scotter, J. M., Allardyce, R., Cook, J., & Swanney, M. P. (2009). Interference of chlorofluorocarbon (CFC)-containing inhalers with measurements of volatile compounds using selected ion flow tube mass spectrometry. Rapid Communications in Mass Spectrometry, 23(3), 443-447. doi: 10.1002/rcm.3875 Ferguson, L. R., Han, D. Y., Huebner, C., Petermann, I., Barclay, M. L., Gearry, R. B., McCulloch, A., & Demmers, P. S. (2009). Tumor necrosis factor receptor superfamily, member 1B haplotypes increase or decrease the risk of inflammatory bowel diseases in a New Zealand Caucasian population. Gastroenterology Research and Practice, 591704. doi: 10.1155/2009/591704 Florkowski, C., Budgen, C., Kendall, D., Lunt, H., & Moore, M. P. (2009). Comparison of blood glucose meters in a New Zealand diabetes centre. Annals of Clinical Biochemistry, 46, 302-305. doi: 10.1258/acb.2009.008193 Forrest, R. H., Itenge-Mweza, T. O., McKenzie, G. W., Zhou, H., Frampton, C. M., & Hickford, J. G. H. (2009). Polymorphism

of the ovine b3-adrenergic receptor gene (ADRB3) and its association with wool mean staple strength and yield. Animal Genetics, 40(6), 958-962. doi: 10.1111/j.1365-2052.2009.01926.x Forrest, R. H. J., Zhou, H., Fang, Q., Smyth, A., Frampton, C. M., & Hickford, J. G. H. (2010). No evidence for a universal association between variation in faecal egg count for a mixed field-challenge of gastrointestinal parasites and the presence of the Ovar-DQA1 null haplotype in sheep. Veterinary Immunology and Immunopathology, 135, 303-305. doi: 10.1016/j. vetimm.2009.12.009 Franke, A., McGovern, D. P. B., Barrett, J. C., Wang, K., Radford-Smith, G. L., Ahmad, T., Lees, C. W., Balschun, T., Lee, J., Roberts, R., ..., Barclay, M., ..., Gearry, R., et al. (2010). Genome-wide meta-analysis increases to 71 the number of confirmed Crohn’s disease susceptibility loci. Nature Genetics, 42(12), 1118-1125. doi: 10.1038/ng.717 Frizelle, F. A., Ing, A., Gearry, R. B., Whitehead, M., Faragher, I. G., & Dobbs, B. (2009). Immunomodulation does not alter histology in resected Crohn’s disease. Techniques in Coloproctology, 13(4), 295-300. doi: 10.1007/s10151-009-0538-7 Gane, E. J., Roberts, S. K., Stedman, C. A. M., Angus, P. W., Ritchie, B., et al. (2010). Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): A randomised, double-blind, placebo-controlled, dose-escalation trial. Lancet, 376(9751), 1467-1475. doi: 10.1016/s0140- 6736(10)61384-0 Gane, E. J., Weilert, F., Orr, D. W., ..., Frampton, C. M., Taylor, K. M., Smith, R. A. J., & Murphy, M. P. (2010). The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients. Liver International, 30(7), 1019-1026. doi: 10.1111/j.1478-3231.2010.02250.x Gearry, R. B., Richardson, A. K., Frampton, C. M., Dodgshun, A. J., & Barclay, M. L. (2010). Population-based cases control study of inflammatory bowel disease risk factors. Journal of Gastroenterology and Hepatology, 25, 325-333. doi: 10.1111/j.1440-1746.2009.06140.x Gladding, P., Mackay, J., Webster, M., White, H., Ellis, K., et al. (2010). Longitudinal study of a 9p21.3 SNP using a national electronic healthcare database. Personalized Medicine, 7(4), 361-369. doi: 10.2217/pme.10.34 Greenslade, M. E., Lunt, H., Kendall, D., & Frampton, C. M. (2009). ‘Introduction to Insulin’ classes: Flexible approach to insulin initiation. Practical Diabetes International, 26(4), 142-144. doi: 10.1002/pdi.1357 Hambleton, P., Keeling, S., & McKenzie, M. (2009). The jungle of quality of life: Mapping measures and meanings for elders [Review article]. Australasian Journal on Ageing, 28(1), 3-6. doi: 10.1111/j.1741-6612.2008.00331.x Hanger, H. C., Wilkinson, T. J., & Mears, A. (2010). Stroke discharges from a rehabilitation unit: 1-year and 5-year domicile outcomes. Function is important. Internal Medicine Journal, 40(1), 45-51. doi: 10.1111/j.1445-5994.2008.01844.x Han, J., Zhou, H., Forrest, R. H., Sedcole, J. R., Frampton, C. M., & Hickford, J. G. H. (2010). Effect of myostatin (MSTN) g+6223G>A on production and carcass traits in New Zealand Romney sheep. Asian-Australasian Journal of Animal Sciences, 23(7), 863-866. Heitger, M. H., Jones, R. D., Macleod, A. D., Snell, D. L., Frampton, C. M., & Anderson, T. J. (2009). Impaired eye movements in post-concussion syndrome indicate suboptimal brain function beyond the influence of depression, malingering or intellectual ability. Brain, 132, 2850-2870. doi: 10.1093/brain/awp181 Heppenstall, C. P., Hanger, H. C., & Wilkinson, T. J. (2009). Predictors of discharge stability in the first year following hospital admission for a frail elderly population. Internal Medicine Journal, 39(3), 170-173. doi: 10.1111/j.1445-5994.2008.01697.x Hickford, J. G. H., Forrest, R. H., Zhou, H., Fang, Q., Han, J., Frampton, C. M., & Horrell, A. L. (2010). Polymorphisms in the ovine myostatin gene (MSTN) and their association with growth and carcass traits in New Zealand Romney sheep. Animal Genetics, 41(1), 64-72. doi: 10.1111/j.1365-2052.2009.01965.x Hildebrandt, P., Collinson, P. O., Doughty, R. N., ..., Richards, M., et al. (2010). Age-dependent values of N-terminal pro-B- type natriuretic peptide are superior to a single cut-point for ruling out suspected systolic dysfunction in primary care. European Heart Journal, 31(15), 1881-1889. doi: 10.1093/eurheartj/ehq163

218 RESEARCH REPORT 2009/2010 Hill, J. V., Findon, G., Appelhoff, R. J., & Endre, Z. H. (2010). Renal autoregulation and passive pressure-flow relationships in diabetes and hypertension. American Journal of Physiology: Renal Physiology, 299(4), F837-F844. doi: 10.1152/ ajprenal.00727.2009 Hoggarth, P. A., Innes, C., Dalrymple-Alford, J. C., Severinsen, J. E., & Jones, R. D. (2010). Comparison of a linear and a non- linear model for using sensory-motor, cognitive, personality, and demographic data to predict driving ability in healthy older adults. Accident Analysis and Prevention, Advance Online Publication. doi: 10.1016/j.aap.2010.04.017 Hollis-Moffatt, J. E., Chen-Xu, M., Topless, R., Dalbeth, N., Gow, P. J., Harrison, A. A., Highton, J., Jones, P. B. B., Nissen, M., Smith, M. D., van Rij, A., Jones, G. T., Stamp, L. K., & Merriman, T. R. (2010). Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: Confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance. Arthritis Research & Therapy, 12(3), R116. doi: 10.1186/ar3053 Hollis-Moffatt, J. E., Merriman, M. E., Rodger, R. A., Rowley, K. A., Chapman, P. T., Dalbeth, N., Gow, P. J., Harrison, A. A., Highton, J., Jones, P. B. B., O’Donnell, J. L., Stamp, L. K., & Merriman, T. R. (2009). Evidence for association of an interleukin 23 receptor variant independent of the R381Q variant with rheumatoid arthritis. Annals of the Rheumatic Diseases, 68(8), 1340-1344. doi: 10.1136/ard.2008.090142 Hollis-Moffatt, J. E., Rowley, K. A., Phipps-Green, A. J., Merriman, M. E., Dalbeth, N., Gow, P., Harrison, A. A., Highton, J., Jones, P. B. B., Stamp, L. K., Harrison, P., Wordsworth, B. P., & Merriman, T. R. (2009). The ITGAV rs3738919 variant and susceptibility to rheumatoid arthritis in four Caucasian sample sets. Arthritis Research & Therapy, 11, R152. doi: 10.1186/ ar2828 Hollis-Moffatt, J. E., Xu, X., Dalbeth, N., Merriman, M. E., Topless, R., Waddell, C., Gow, P. J., Harrison, A. A., Highton, J., Jones, P. B. B., Stamp, L. K., & Merriman, T. R. (2009). Role of the urate transporter SLC2A9 gene in susceptibility to gout in New Zealand Mäori, Pacific Island, and Caucasian case-control sample sets. Arthritis and Rheumatism, 60(11), 3485- 3492. doi: 10.1002/art.24938 Hooper, G. J., Rothwell, A. G., Stringer, M., & Frampton, C. (2009). Revision following cemented and uncemented primary total hip replacement: A seven-year analysis from the New Zealand Joint Registry. Journal of Bone & Joint Surgery (Br), 91- B(4), 451-458. doi: 10.1302/0301-620X.91B4 Hooper, G., Rothwell, A., & Frampton, C. (2009). The low contact stress mobile-bearing total knee replacement: A prospective study with a minimum follow-up of ten years. Journal of Bone & Joint Surgery (Br), 91-B(1), 58-63. doi: 10.1302/0301-620X.91B1 Huebner, C., Browning, B. L., Petermann, I., Han, D. Y., Philpott, M., Barclay, M., Gearry, R., McCulloch, A., Demmers, P., & Ferguson, L. R. (2009). Genetic analysis of MDR1 and inflammatory bowel disease reveals protective effect of heterozygous variants for ulcerative colitis. Inflammatory Bowel Diseases, 15(12), 1784-1793. doi: 10.1002/ibd.21019 Huebner, C., Ferguson, L. R., Han, D. Y., Philpott, M., Barclay, M. L., Gearry, R. B., et al. (2009). Nucleotide-binding oligomerization domain containing I (NODI) haplotypes and single nucleotide polymorphisms modify susceptibility to inflammatory bowel diseases in a New Zealand Caucasian population: A case-control study. BMC Research Notes, 2. doi: 10.1186/1756-0500-2-52 Hunt, M. A., Currie, M. J., Robinson, B. A., & Dachs, G. U. (2010). Optimizing transfection of primary human umbilical vein endothelial cells using commercially available chemical transfection reagents. Journal of Biomolecular Techniques, 21, 66- 72. Hutchinson, C., Hanger, C., Wilkinson, T., Sainsbury, R., & Pithie, A. (2009). Spontaneous spinal infections in older people. Internal Medicine Journal, 39(12), 845-848. doi: 10.1111/j.1445-5994.2009.02052.x Hu, W-P., Langford, V. S., McEwan, M. J., Milligan, D. B., Storer, M. K., Dummer, J., & Epton, M. J. (2010). Monitoring chloramines and bromamines in a humid environment using selected ion flow tube mass spectrometry. Rapid Communications in Mass Spectrometry, 24(12), 1744-1748. doi: 10.1002/rcm.4570 Innes, C. R. H., Jones, R. D., Anderson, T. J., Hollobon, S., & Dalrymple-Alford, J. (2009). Performance in normal subjects on a novel battery of driving-related sensory-motor and cognitive tests. Behavior Research Methods, 41(2), 284-294. Jacobsen, L. V., Hindsberger, C., Robson, R., & Zdravkovic, M. (2009). Effect of renal impairment on the pharmacokinetics of the GLP-1 analogue liraglutide. British Journal of Clinical Pharmacology, 68(6), 898-905. doi: 10.1111/j.1365- 2125.2009.03536.x James, M. L., Lehman, M., Hider, P. N., Jeffery, M., Hickey, B. E., & Francis, D. P. (2010). Fraction size in radiation treatment for breast conservation in early breast cancer. Cochrane Database of Systematic Reviews, 11, CD003860. doi: 10.1002/14651858.CD003860.pub3 Jardine, D. L., Krediet, C. T. P., Cortelli, P., Frampton, C. M., & Wieling, W. (2009). Sympatho-vagal responses in patients with sleep and typical vasovagal syncope. Clinical Science, 117, 345-353. doi: 10.1042/CS20080497 Jarvis, M. D., Palmer, B. R., Pilbrow, A. P., Ellis, K. L., Frampton, C. M., Skelton, L., Doughty, R. N., Whalley, G. A., Ellis, C. J., Yandle, T. G., Richards, A. M., & Cameron, V. A. (2010). CYP1A1 MSPI (T6235C) gene polymorphism is associated with mortality in acute coronary syndrome patients. Clinical and Experimental Pharmacology and Physiology, 37(2), 193-198. doi: 10.1111/j.1440-1681.2009.05261.x Johnstone, J. M., Luty, S. E., Carter, J. D., Mulder, R. T., Frampton, C. M. A., & Joyce, P. R. (2009). Childhood neglect and abuse as predictors of antidepressant response in adult depression. Depression and Anxiety, 26(8), 711-717. doi: 10.1002/ da.20590 Jones, P., Dalziel, S. R., Lamdin, R., Miles, J., & Frampton, C. (2009). Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. Cochrane Database of Systematic Reviews, (2), CD007789. doi: 10.1002/14651858.CD007789

Division of HEALTH SCIENCES 219 Jonker, J. W., Stedman, C. A. M., Liddle, C., & Downes, M. (2009). Hepatobiliary ABC transporters: Physiology, regulation and implications for disease. Frontiers in Bioscience, 14, 4904-4920. doi: 10.2741/3576 Jordan, J., Joyce, P. R., Carter, F. A., McIntosh, V. V. W., Luty, S. E., McKenzie, J. M., Frampton, C. M. A., & Bulik, C. M. (2009). The Yale-Brown-Cornell Eating Disorder Scale in women with anorexia nervosa: What is it measuring? International Journal of Eating Disorders, 42(3), 267-274. doi: 10.1002/eat.20605 Joshy, G., Porter, T., Le Lievre, C., Lane, J., Williams, M., & Lawrenson, R. (2009). Prevalence of diabetes in New Zealand general practice: The influence of ethnicity and social deprivation. Journal of Epidemiology and Community Health, 63(5), 386-390. doi: 10.1136/jech.2008.078873 Joshy, G., Porter, T., Le Lievre, C., Lane, J., Williams, M., & Lawrenson, R. (2010). Implication of using estimated glomerular filtration rate (GFR) in a multi ethnic population of diabetes patients in general practice. New Zealand Medical Journal, 123(1310). Retrieved from http://www.nzma.org.nz/journal/123-1310/4000/ Kelly, P. T., Swanney, M. P., Seccombe, L. M., Frampton, C., Peters, M. J., & Beckert, L. E. (2009). Predicting the response to air travel in passengers with non-obstructive lung disease: Are the current guidelines appropriate? Respirology, 14(4), 567-573. doi: 10.1111/j.1440-1843.2009.01520.x Kelly, P. T., Swanney, M. P., Stanton, J. D., Frampton, C. M., Peters, M. J., & Beckert, L. E. (2009). Resting and exercise response to altitude in patients with chronic obstructive pulmonary disease. Aviation Space and Environmental Medicine, 80(2), 102-107. doi: 10.3357/ASEM.2434.2009 Kelly, P. T., Swanney, M. P., Stanton, J., Frampton, C., Peters, M. J., & Beckert, L. E. (2009). Supplemental oxygen effect on hypoxemia at moderate altitude in patients with copd. Aviation Space & Environmental Medicine, 80(9), 815-819. doi: 10.3357/ASEM.2550.2009 Kerse, N., Hayman, K. J., Moyes, S. A., Peri, K., Robinson, E., Dowell, A., ..., Keeling, S., et al. (2010). Home-based activity program for older people with depressive symptoms: DeLLITE-a randomized controlled trial. Annals of Family Medicine, 8(3), 214-223. doi: 10.1370/afm.1093 King, R. I., Scott, R. S., Florkowski, C. M., Laurie, A. D., Reid, N., & George, P. M. (2010). Homozygous familial hypercholesterolaemia and treatment by LDL apheresis. New Zealand Medical Journal, 123(1319). Retrieved from http:// www.nzma.org.nz/journal/123-1319/4230/ Lainchbury, J. G., Troughton, R. W., Strangman, K. M., Frampton, C. M., Pilbrow, A., Yandle, T. G., Hamid, A. K., Nicholls, M. G., & Richards, A. M. (2010). N-terminal pro-B-type natriuretic peptide-guided treatment for chronic heart failure: Results from the BATTLESCARRED (NT-proBNP-assisted treatment to lessen serial cardiac readmissions and death) trial. Journal of the American College of Cardiology, 55(1), 53-60. doi: 10.1016/j.jacc.2009.02.095 Laugesen, M., Epton, M., Frampton, C. M. A., Glover, M., & Lea, R. A. (2009). Hand-rolled cigarette smoking patterns compared with factory-made cigarette smoking in New Zealand men. BMC Public Health, 9, 194. doi: 10.1186/1471-2458- 9-194 Le Compte, A., Chase, J. G., Russell, G., Lynn, A., Hann, C., Shaw, G., Wong, X-W., Blakemore, A., & Lin, J. (2010). Modeling the glucose regulatory system in extreme preterm infants. Computer Methods and Programs in Biomedicine, Advance Online Publication. doi: 10.1016/j.cmpb.2010.05.006 Leow, L. P., Huckabee, M-L., Anderson, T., & Beckert, L. (2010). The impact of dysphagia on quality of life in ageing and Parkinson’s disease as measured by the Swallowing Quality of Life (SWAL-QOL) questionnaire. Dysphagia, 25(3), 216- 220. doi: 10.1007/s00455-009-9245-9 Lever, M., George, P. M., Slow, S., Elmslie, J. L., Scott, R. S., Richards, A. M., Fink, J. N., & Chambers, S. T. (2009). Fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine. Cardiovascular Drugs and Therapy, 23(5), 395-401. doi: 10.1007/s10557-009-6188-1 Lever, M., George, P. M., Slow, S., Elmslie, J. L., Shand, B. I., Scott, R. S., & Chambers, S. T. (2010). Fibrates plus betaine: A winning combination? [Viewpoint]. New Zealand Medical Journal, 123(1324). Retrieved from http://www.nzma.org.nz/ journal/123-1324/4389/content.pdf Lewis, J. G., Borowski, K. K., Shand, B. I., George, P. M., & Scott, R. S. (2010). Plasma sex hormone-binding globulin, corticosteroid-binding globulin, cortisol, and free cortisol levels in outpatients attending a lipid disorders clinic: A cross- sectional study of 1137 subjects. Hormone and Metabolic Research, 42(4), 274-279. doi: 10.1055/s-0029-1243260 Lewis, J. G., Shand, B. I., Frampton, C. M., Elder, P. A., & Scott, R. S. (2009). Plasma levels of sex hormone-binding globulin, corticosteroid-binding globulin and cortisol in overweight subjects who develop impaired fasting glucose: A 3-year prospective study. Hormone and Metabolic Research, 41(3), 255-259. doi: 10.1055/s-0028-1087190 Light, K. J., Joyce, P. R., & Frampton, C. M. A. (2009). Description and validation of the Affective Temperament Questionnaire. Comprehensive Psychiatry, 50(5), 477-484. doi: 10.1016/j.comppsych.2007.07.008 Lin, J., Parente, J. D., Chase, J. G., Shaw, G. M., Blakemore, A. J., LeCompte, A. J., Pretty, C., Razak, N. N., Lee, D. S., Hann, C. E., & Wang, S-H. (2010). Development of a model-based clinical sepsis biomarker for critically ill patients. Computer Methods and Programs in Biomedicine, Advance Online Publication. doi: 10.1016/j.cmpb.2010.04.002 Lin, Y-S., Zhou, H., Forrest, R. H. J., Frampton, C. M., & Hickford, J. G. H. (2009). Association between variation in faecal egg count for a mixed field-challenge of nematode parasites and IGHA gene polymorphism. Veterinary Immunology and Immunopathology, 128(4), 389-394. doi: 10.1016/j.vetimm.2008.12.005 Lowe, S. A., Brown, M. A., Dekker, G. A., ..., Moore, M. P., et al. (2009). Guidelines for the management of hypertensive disorders of pregnancy 2008. Australian and New Zealand Journal of Obstetrics and Gynaecology, 49, 242-246. doi: 10.1111/j.1479-828X.2009.01003.x

220 RESEARCH REPORT 2009/2010 Lunt, H., Florkowski, C., Bignall, M., & Budgen, C. (2010). Capillary glucose meter accuracy and sources of error in the ambulatory setting. New Zealand Medical Journal, 123(1310). Retrieved from http://www.nzma.org.nz/ journal/123-1310/4018/ Mace, J. L., Porter, R. J., Dalrymple-Alford, J. C., & Anderson, T. J. (2010). The effects of acute tryptophan depletion on mood in patients with Parkinson’s disease and the healthy elderly. Journal of Psychopharmacology, 24(4), 615-619. doi: 10.1177/0269881109105572 Mace, J. L., Porter, R. J., Dalrymple-Alford, J. C., Wesnes, K. A., & Anderson, T. J. (2010). Effects of acute tryptophan depletion on neuropsychological and motor function in Parkinson’s disease. Journal of Psychopharmacology, 24(10), 1465-1472. doi: 10.1177/0269881109105721 Mackenzie, K. A., Wells, J. E., Lynn, K. L., Simcock, J. W., Robinson, B. A., Roake, J. A., & Currie, M. J. (2010). First and subsequent nonmelanoma skin cancers: Incidence and predictors in a population of New Zealand renal transplant recipients. Nephrology Dialysis Transplantation, 25, 300-306. doi: 10.1093/ndt/gfp482 Maisel, A., Mueller, C., Nowak, R., ..., Richards, M., et al. (2010). Mid-region pro-hormone markers for diagnosis and prognosis in acute dyspnea: Results from the BACH (Biomarkers in Acute Heart Failure) trial. Journal of the American College of Cardiology, 55(19), 2062-2076. doi: 10.1016/j.jacc.2010.02.025 Mander, T. J., Rodgers, G. W., Chase, J. G., Mander, J. B., MacRae, G. A., & Dhakal, R. P. (2009). Damage avoidance design steel beam-column moment connection using high-force-to-volume dissipators. Journal of Structural Engineering, 135(11), 1390-1397. doi: 10.1061/(ASCE)ST.1943-541X.0000065 Marshall, C. J., Nallaratnam, M., Mocatta, T., Smyth, D., Richards, M., Elliott, J. M., Blake, J., Winterbourn, C. C., Kettle, A. J., & McClean, D. R. (2010). Factors influencing local and systemic levels of plasma myeloperoxidase in ST-segment elevation acute myocardial infarction. American Journal of Cardiology, 106(3), 316-322. doi: 10.1016/j.amjcard.2010.03.028 McKimm, J., Sheehan, D., Poole, P., Barrow, M., Dockerty, J., Wilkinson, T. J., & Wearn, A. (2010). Interprofessional learning in medical education in New Zealand. New Zealand Medical Journal, 123(1320). Retrieved from http://www.nzma.org.nz/ journal/archive.php McKinney, C., Fanciulli, M., Merriman, M. E., Phipps-Green, A., ..., Harrison, A. A., Highton, J., Jones, P. B., Stamp, L. K., ..., & Merriman, T. R. (2010). Association of variation in Fcg receptor 3B gene copy number with rheumatoid arthritis in Caucasian samples. Annals of the Rheumatic Diseases, 69, 1711-1716. doi: 10.1136/ard.2009.123588 McLellan, T., Johnston, L., Dalrymple-Alford, J., & Porter, R. (2010). Sensitivity to genuine versus posed emotion specified in facial displays. Cognition & Emotion, 24(8), 1277-1292. doi: 10.1080/02699930903306181 McNeill, B. A., Barrell, G. K., Wellby, M., Prickett, T. C. R., Yandle, T. G., & Espiner, E. A. (2009). C-type natriuretic peptide forms in pregnancy: Maternal plasma profiles during ovine gestation correlate with placental and fetal maturation. Endocrinology, 150(10), 4777-4783. doi: 10.1210/en.2009-0176 McNeill, B. A., Prickett, T. C. R., Wellby, M., Ridgway, M. J., Espiner, E. A., & Barrell, G. K. (2010). Circulating levels of C-type natriuretic peptide (CNP) are strongly linked to pregnancy but not to liveweight change in ruminants. Proceedings of the New Zealand Society of Animal Production, 70, 13-18. Merry, A. F., Gibbs, R. D., Edwards, J., Ting, G. S., Frampton, C., Davies, E., & Anderson, B. J. (2010). Combined acetaminophen and ibuprofen for pain relief after oral surgery in adults: A randomized controlled trial. British Journal of Anaesthesia, 104(1), 80-88. doi: 10.1093/bja/aep338 Miller, L. J., Pearce, J., Barnett, R., Willis, J., Darlow, B. A., & Scott, R. S. (2009). Is population mixing associated with childhood type 1 diabetes in Canterbury, New Zealand? Social Science and Medicine, 68(4), 625-630. doi: 10.1016/j. socscimed.2008.11.027 Miller, L. J., Willis, J. A., Pearce, J., Barnett, R., Darlow, B. A., & Scott, R. S. (2010). Urban-rural variation in childhood type 1 diabetes incidence, in Canterbury, New Zealand 1980 to 2004. Health & Place, Advance Online Publication. doi: 10.1016/j. healthplace.2010.10.010

Molyneux, S. L., Florkowski, C. M., Richards, A. M., Lever, M., Young, J. M., & George, P. M. (2009). Coenzyme Q10; an adjunctive therapy for congestive heart failure? New Zealand Medical Journal, 122(1305). Retrieved from http://www. nzma.org.nz/journal/122-1305/3855/ Monro, J. A., Wallace, A., Mishra, S., Eady, S., Willis, J. A., Scott, R. S., & Hedderley, D. (2010). Relative glycaemic impact of customarily consumed portions of eighty-three foods measured by digesting in vitro and adjusting for food mass and apparent glucose disposal. British Journal of Nutrition, 104(3), 407-417. doi: 10.1017/S0007114510000589 Moorhead, K. T., Hill, J. V., Chase, J. G., Hann, C. E., Scotter, J. M., Storer, M. K., & Endre, Z. H. (2010). Modelling acute renal failure using blood and breath biomarkers in rats. Computer Methods and Programs in Biomedicine, Advance Online Publication. doi: 10.1016/j.cmpb.2010.07.010 Moses, R. G., Bartley, P., Lunt, H., O’Brien, R. C., Donnelly, T., Gall, M-A., et al. (2009). Safety and efficacy of inhaled insulin (AERxÒ iDMS) compared with subcutaneous insulin therapy in patients with Type 1 diabetes: 1-year data from randomized, parallel group trial. Diabetic Medicine, 26(3), 260-267. doi: 10.1111/j.1464-5491.2008.02654.x Mulder, R. T., Frampton, C. M. A., Luty, S. E., & Joyce, P. R. (2009). Eighteen months of drug treatment for depression: Predicting relapse and recovery. Journal of Affective Disorders, 114(1-3), 263-270. doi: 10.1016/j.jad.2008.08.002 Mulder, R. T., Joyce, P. R., & Frampton, C. M. A. (2009). Personality disorders improve in patients treated for major depression. Acta Psychiatrica Scandinavica, 122, 219-225. doi: 10.1111/j.1600-0447.2009.01502.x Mulligan, K. J., Chase, J. G., Mander, J. B., Rodgers, G. W., & Elliott, R. B. (2010). Nonlinear models and validation for resetable device design and enhanced force capacity. Structural Control and Health Monitoring, 17(3), 301-316. doi: 10.1002/stc.298

Division of HEALTH SCIENCES 221 Mulligan, K. J., Chase, J. G., Mander, J. B., Rodgers, G. W., Elliott, R. B., Franco-Anaya, R., & Carr, A. J. (2009). Experimental validation of semi-active resetable actuators in a 1/5th scale test structure. Earthquake Engineering and Structural Dynamics, 38(4), 517-536. doi: 10.1002/eqe.868 Navaneethan, S. D., Palmer, S. C., Smith, A., Johnson, D. W., & Strippoli, G. F. M. (2010). How to design a randomised controlled trial. Nephrology, Advance Online Publication. doi: 10.1111/j.1440-1797.2010.01428.x Nejat, M., Pickering, J. W., Walker, R. J., & Endre, Z. H. (2010). Rapid detection of acute kidney injury by plasma cystatin C in the intensive care unit. Nephrology, Dialysis, Transplantation, 25, 3283-3289. doi: 10.1093/ndt/gfq176 Nejat, M., Pickering, J. W., Walker, R. J., Westhuyzen, J., Shaw, G. M., Frampton, C. M., & Endre, Z. H. (2010). Urinary cystatin C is diagnostic of acute kidney injury and sepsis, and predicts mortality in the intensive care unit. Critical Care, 14(3), R85. doi: 10.1186/cc9014 Ngu, J. H., Bechly, K., Chapman, B. A., Burt, M. J., Barclay, M. L., Gearry, R. B., & Stedman, C. A. M. (2010). Population-based epidemiology study of autoimmune hepatitis: A disease of older women? Journal of Gastroenterology and Hepatology, 25(10), 1681-1686. doi: 10.1111/j.1440-1746.2010.06384.x Nicholls, M. G., Lewis, L. K., Yandle, T. G., Lord, G., Mckinnon, W., & Hilton, P. J. (2009). Ouabain, a circulating hormone secreted by the adrenals, is pivotal in cardiovascular disease. Fact or fantasy? Journal of Hypertension, 27(1), 3-8. doi: 10.1097/HJH.0b013e32831101d1 Norrie, J., Heitger, M., Leathem, J., Anderson, T., Jones, R., & Flett, R. (2010). Mild traumatic brain injury and fatigue: A prospective longitudinal study. Brain Injury, 24(13-14), 1528-1538. doi: 10.3109/02699052.2010.531687 O’Brien, I., Britton, E. J., Sarfati, D., Naylor, W., Borman, B., Ellison-Loschmann, L., Simpson, A., Tamblyn, C., & Atkinson, C. (2010). The voice of experience: Results from Cancer Control New Zealand’s first national cancer care survey. New Zealand Medical Journal, 123(1325). Retrieved from http://www.nzma.org.nz/journal/123-1325/4419/content.pdf O’Connell, J., Kieran, P., Gorman, K., Ahern, T., Cawood, T. J., & O’Shea, D. (2010). BMI ³ 50 kg/m2 is associated with a younger age of onset of overweight and a high prevalence of adverse metabolic profiles. Public Health Nutrition, 13(7), 1090-1098. doi: 10.1017/S1368980009993193 O’Connell, J., Lynch, L., Cawood, T. J., Kwasnik, A., Nolan, N., Geoghegan, J., et al. (2010). The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity. PLoS ONE, 5(4), e9997. doi: 10.1371/journal. pone.0009997 Ooi, C. J., Fock, K. M., Makharia, G. K., ..., Gearry, R. B., et al. (2010). The Asia-Pacific consensus on ulcerative colitis. Journal of Gastroenterology and Hepatology, 25(3), 453-468. doi: 10.1111/j.1440-1746.2010.06241.x O’Shea, D., Cawood, T. J., O’Farrelly, C., & Lynch, L. (2010). Natural killer cells in obesity: Impaired function and increased susceptibility to the effects of cigarette smoke. PLoS ONE, 5(1), e8660. doi: 10.1371/journal.pone.0009997 Palmer, B. R., Devereaux, C. L., Dhamrait, S. S., Mocatta, T. J., Pilbrow, A. P., Frampton, C. M., Skelton, L., Yandle, T. G., Winterbourn, C. C., Richards, A. M., Montgomery, H. E., & Cameron, V. A. (2009). The common G-866A polymorphism of the UCP2 gene and survival in diabetic patients following myocardial infarction. Cardiovascular Diabetology, 8. doi: 10.1186/1475-2840-8-31 Palmer, S. C., Endre, Z. H., Richards, A. M., & Yandle, T. G. (2009). Characterization of NT-proBNP in human urine. Clinical Chemistry, 55(6), 1126-1134. doi: 10.1373/clinchem.2008.121673 Palmer, S. C., Navaneethan, S. D., Craig, J. C., Johnson, D. W., Tonelli, M., Garg, A. X., et al. (2010). Systematic review: Erythropoiesis-stimulating agents in patients with chronic kidney disease. Annals of Internal Medicine, Advance Online Publication. doi: 10.1059/0003-4819-153-1-201007060-00252 Palmer, S. C., Navaneethan, S. D., & Strippoli, G. F. M. (2010). How to read a nephrology systematic review. Nephrology, 15(2), 158-164. doi: 10.1111/j.1440-1797.2010.01284.x Palmer, S. C., Prickett, T. C. R., Espiner, E. A., Yandle, T. G., & Richards, A. M. (2009). Regional release and clearance of C-type natriuretic peptides in the human circulation and relation to cardiac function. Hypertension, 54(3), 612-618. doi: 10.1161/ HYPERTENSIONAHA.109.135608 Palmer, S. C., Yandle, T. G., Frampton, C. M., Troughton, R. W., Nicholls, M. G., & Richards, A. M. (2009). Renal and cardiac function for long-term (10 year) risk stratification after myocardial infarction. European Heart Journal, 30, 1486-1494. doi: 10.1093/eurheartj/ehp132 Palmer, S. C., Yandle, T. G., Nicholls, M. G., Frampton, C. M., & Richards, A. M. (2009). Regional clearance of amino-terminal pro-brain natriuretic peptide from human plasma. European Journal of Heart Failure, 11, 832-839. doi: 10.1093/eurjhf/ hfp099 Paton, L. N., Mocatta, T. J., Richards, A. M., & Winterbourn, C. C. (2010). Increased thrombin-induced polymerization of fibrinogen associated with high protein carbonyl levels in plasma from patients post myocardial infarction. Free Radical Biology & Medicine, 48(2), 223-229. doi: 10.1016/j.freeradbiomed.2009.10.044 Pearse, A. J., Hooper, G. J., Rothwell, A., & Frampton, C. (2010). Survival and functional outcome after revision of a unicompartmental to a total knee replacement: The New Zealand National Joint Registry. Journal of Bone and Joint Surgery, 92(4), 508-512. doi: 10.1302/0301-620X.92B4.22659 Pearson, L. J., Yandle, T. G., Nicholls, M. G., & Evans, J. J. (2009). Intermedin (Adrenomedullin-2): A potential protective role in human aortic endothelial cells. Cellular Physiology and Biochemistry, 23(1-3), 97-108. Perry, W. R. G., & Wilkinson, T. J. (2010). Taking the pulse: Medical student workforce intentions and the impact of debt. New Zealand Medical Journal, 123(1318). Retrieved from http://www.nzma.org.nz/journal/archive.php

222 RESEARCH REPORT 2009/2010 Petermann, I., Huebner, C., Browning, B. L., Gearry, R. B., Barclay, M. L., Kennedy, M., Roberts, R., Shelling, A. N., Philpott, M., Han, D. Y., & Ferguson, L. R. (2009). Interactions among genes influencing bacterial recognition increase IBD risk in a population-based New Zealand cohort. Human Immunology, 70, 440-446. doi: 10.1016/j.humimm.2009.03.002 Petermann, I., Triggs, C. M., Huebner, C., Han, D. Y., Gearry, R. B., Barclay, M. L., Demmers, P. S., McCulloch, A., & Ferguson, L. (2009). Mushroom intolerance: A novel diet-gene interaction in Crohn’s disease. British Journal of Nutrition, 102(4), 506-508. doi: 10.1017/s0007114509276446 Phipps-Green, A. J., Hollis-Moffatt, J. E., Dalbeth, N., Merriman, M. E., Topless, R., Gow, P. J., Harrison, A. A., Highton, J., Jones, P. B. B., Stamp, L. K., & Merriman, T. R. (2010). A strong role for the ABCG2 gene in susceptibility to gout in New Zealand Pacific Island and Caucasian, but not Mäori, case and control sample sets. Human Molecular Genetics, 19(24), 4813-4819. doi: 10.1093/hmg/ddq412 Pickering, J. W., & Endre, Z. H. (2009). Secondary prevention of acute kidney injury. Current Opinion in Critical Care, 15(6), 488-497. doi: 10.1097/MCC.0b013e328332f66f Pickering, J. W., & Endre, Z. H. (2010). Back-calculating baseline creatinine with MDRD misclassifies acute kidney injury in the intensive care unit. Clinical Journal of the American Society of Nephrology, 5, 1165-1173. doi: 10.2215/CJN.08531109 Pickering, J. W., Frampton, C. M., & Endre, Z. H. (2009). Evaluation of trial outcomes in acute kidney injury by creatinine modeling. Clinical Journal of the American Society of Nephrology, 4(11), 1705-1715. doi: 10.2215/cjn.00820209 Poole, P. J., Moriarty, H. J., Wearn, A. M., Wilkinson, T. J., & Weller, J. M. (2009). Medical student selection in New Zealand: Looking to the future. New Zealand Medical Journal, 122(1306). Retrieved from http://www.nzma.org.nz/ journal/122-1306/3884/ Poppe, K. K., Whalley, G. A., Richards, A. M., Wright, S. P., Triggs, C. M., & Doughty, R. N. (2010). Prediction of ACC/AHA stage B heart failure by clinical and neurohormonal profiling among patients in the community. Journal of Cardiac Failure, Advance Online Publication. doi: 10.1016/j.cardfail.2010.07.247 Poppitt, S. D., Howe, C. A., Lithander, F. E., Silvers, K. M., Lin, R-B., Croft, J., Ratnasabapathy, Y., Gibson, R. A., & Anderson, C. S. (2009). Effects of moderate-dose omega-3 fish oil on cardiovascular risk factors and mood after ischemic stroke: A randomized, controlled trial. Stroke, 40(11), 3485-3492. doi: 10.1161/strokeaha.109.555136 Poudel, G. R., Jones, R. D., Innes, C. R. H., Watts, R., Davidson, P. J., & Bones, P. J. (2010). Measurement of BOLD changes due to cued eye-closure and stopping during a continuous visuomotor task via model-based and model-free approaches. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 18(5), 479-488. doi: 10.1109/TNSRE.2010.2050782 Pöyhönen-Alho, M., Viitasalo, M., Nicholls, M. G., Lindström, B-M., Väänänen, H., & Kaaja, R. (2010). Imbalance of the autonomic nervous system at night in women with gestational diabetes. Diabetic Medicine, 27(9), 988-994. doi: 10.1111/j.1464-5491.2010.03062.x Pradhan, M. A., Ng, Y., Strickland, A., George, P. M., Raizis, A., Warrington, J., & Vincent, A. L. (2010). Role of genetic testing in retinoblastoma management at a tertiary referral centre. Clinical and Experimental Ophthalmology, 38, 231-236. doi: 10.1111/j.1442-9071.2010.02239.x Prickett, T. C. R., Charles, C. J., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2009). Skeletal contributions to plasma CNP forms: Evidence from regional sampling in growing lambs. Peptides, 30(12), 2343-2347. doi: 10.1016/j. peptides.2009.07.023 Prickett, T. C. R., McNeill, B. A., Oliver, M. H., Harding, J. E., & Espiner, E. A. (2010). Effect of cortisol on C-type natriuretic peptide (CNP) in ovine pregnancy: Differential responses in fetal and placental tissues. Pediatric Research, Advance Online Publication. doi: 10.1203/PDR.0b013e3181f9039d Prickett, T. C. R., Ryan, J. F., Wellby, M., Barrell, G. K., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2010). Effect of nutrition on plasma C-type natriuretic peptide forms in adult sheep: Evidence for enhanced C-type natriuretic peptide degradation during caloric restriction. Metabolism: Clinical and Experimental, 59(6), 796-801. doi: 10.1016/j.metabol.2009.09.026 Prosser, H. C., Forster, M. E., Richards, A. M., & Pemberton, C. J. (2010). Regional vascular response to ProAngiotensin-12 (PA12) through the rat arterial system. Peptides, 31, 1540-1545. doi: 10.1016/j.peptides.2010.05.009 Prosser, H. C. G., Forster, M. E., Richards, A. M., & Pemberton, C. J. (2009). Cardiac chymase converts rat proAngiotensin-12 (PA12) to angiotensin II: Effects of PA12 upon cardiac haemodynamics. Cardiovascular Research, 82(1), 40-50. doi: 10.1093/cvr/cvp003 Rademaker, M. T., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2009). Urocortin 2 inhibits furosemide-induced activation of renin and enhances renal function and diuretic responsiveness in experimental heart failure. Circulation Heart Failure, 2(6), 532-540. doi: 10.1161/CIRCHEARTFAILURE.109.861336 Raizis, A. M., Saleem, M., MacKay, R., & George, P. M. (2009). Spectrum of MECP2 mutations in New Zealand Rett syndrome patients. New Zealand Medical Journal, 122(1296). Retrieved from http://www.nzma.org.nz/journal/122-1296/3634 Rhodes, B., Merriman, M. E., Harrison, A., Nissen, M. J., Smith, M., Stamp, L., Steer, S., Merriman, T. R., & Vyse, T. J. (2010). A genetic association study of serum acute-phase C-reactive protein levels in rheumatoid arthritis: Implications for clinical interpretation. PLoS Medicine, 7(9), e1000341. doi: 10.1371/journal.pmed.1000341 Richards, A. M. (2010). B-type natriuretic peptide-guided therapy for chronic heart failure reduces all-cause mortality compared with usual care but does not affect all-cause hospitalisation or survival free of hospitalisation. Evidence-Based Medicine, Advance Online Publication. doi: 10.1136/ebm1084 Richards, A. M. (2010). New biomarkers in heart failure: Applications in diagnosis, prognosis and guidance of therapy. Revista Espanola de Cardiologia, 63(6), 635-639.

Division of HEALTH SCIENCES 223 Ritzema, J., Troughton, R., Melton, I., Crozier, I., ..., Richards, M., ..., Frampton, C. M., et al. (2010). Physician-directed patient self-management of left atrial pressure in advanced chronic heart failure. Circulation, 121, 1086-1095. doi: 10.1161/ CIRCULATIONAHA.108.800490 Roberts, R. L., Topless, R. K. G., Phipps-Green, A. J., Gearry, R. B., Barclay, M. L., & Merriman, T. R. (2010). Evidence of interaction of CARD8 rs2043211 with NALP3 rs35829419 in Crohn’s disease. Genes and Immunity, 11, 351-356. doi: 10.1038/gene.2010.11 Rodgers, G. W., Chase, J. G., Mulligan, K. J., Mander, J. B., & Elliott, R. B. (2009). Customising semi-active resetable device behaviour for abating seismic structural response. Bulletin of the New Zealand Society for Earthquake Engineering, 42(3), 147-156. Rodgers, G. W., Mander, J. B., & Chase, J. G. (2010). Semi-explicit rate-dependent modeling of damage-avoidance steel connections using HF2V damping devices. Earthquake Engineering and Structural Dynamics, Advance Online Publication. doi: 10.1002/eqe.1073 Rodgers, G. W., Solberg, K. M., Mander, J. B., Chase, J. G., Bradley, B. A., & Dhakal, R. P. (2010). High-force-to-volume seismic dissipators embedded in a jointed precast concrete frame. Journal of Structural Engineering, Advance Online Publication. doi: 10.1061/(ASCE)ST.1943-541X.0000329 Rodwell, J., Fletcher, V., & Hughes, R. (2010). How well is cognitive function documented by medical staff in the over-65 age group at the time of acute medical admission? New Zealand Medical Journal, 123(1317). Retrieved from http://www.nzma. org.nz/journal/123-1317/4182/content.pdf Rossi, A., Temporelli, P. L., Quintana, M., ..., on behalf of the MeRGE HF Collaborators, including Frampton, C. M., & Troughton, R. (2009). Independent relationship of left artial size and mortality in patients with heart failure: An individual patient meta-analysis of longitudinal data (MeRGE Heart Failure). European Journal of Heart Failure, 11, 929-936. doi: 10.1093/eurjhf/hfp112 Ross, I., Boulle, A., Soule, S., Levitt, N., Pirie, F., Karlsson, A., et al. (2010). Autoimmunity predominates in a large South African cohort with addison’s disease of mainly European descent despite long-standing disease and is associated with HLA DQB*0201. Clinical Endocrinology, 73(3), 291-298. doi: 10.1111/j.1365-2265.2010.03807.x Rothwell, A. G., Hooper, G. J., Hobbs, A., & Frampton, C. M. (2010). An analysis of the Oxford hip and knee scores and their relationship to early joint revision in the New Zealand Joint Registry. Journal of Bone and Joint Surgery (Br), 92B(3), 413- 418. doi: 10.1302/0301-620x.92b3.22913 Rowan, J. A., Luen, S., Hughes, R. C., Sadler, L. C., & McCowan, L. M. E. (2009). Customised birthweight centiles are useful for identifying small-for-gestational-age babies in women with type 2 diabetes. Australian and New Zealand Journal of Obstetrics and Gynaecology, 49(2), 180-184. doi: 10.1111/j.1479-828X.2009.00975.x Rowe, S., Jordan, J., McIntosh, V., Carter, F., Frampton, C., Bulik, C., & Joyce, P. (2010). Dimensional measures of personality as a predictor of outcome at 5-year follow-up in women with bulimia nervosa. Psychiatry Research, Advance Online Publication. doi: 10.1016/j.psychres.2010.07.017 Rowe, S. L., Jordan, J., McIntosh, V. V. W., Carter, F. A., Frampton, C., Bulik, C. M., & Joyce, P. R. (2010). Complex personality disorder in bulimia nervosa. Comprehensive Psychiatry, Advance Online Publication. doi: 10.1016/j. comppsych.2010.02.012 Saadi, H. F., Nicholls, M. G., Frampton, C. M., Benedict, S., & Yasin, J. (2009). Serum 25-hydroxyvitamin D is not related to cardiac natriuretic peptide in nulliparous and lactating women. BMC Endocrine Disorders, 9. doi: 10.1186/1472-6823-9-4 Sakowska, M., Docherty, E., Linscott, D., & Connor, S. (2009). A change in practice from epidural to intrathecal morphine analgesia for hepato-pancreato-biliary surgery. World Journal of Surgery, 33(9), 1802-1808. doi: 10.1007/s00268-009-0131-2 Salah Kamel, K., Beckert, L. E., & Stringer, M. D. (2009). Novel insights into the elastic and muscular components of the human trachea. Clinical Anatomy, 22(6), 689-697. doi: 10.1002/ca.20841 Sallach, J. A., Wilson Tang, W. H., Borowski, A. G., ..., Troughton, R. W., & Klein, A. L. (2009). Right atrial volume index in chronic systolic heart failure and prognosis. JACC: Cardiovascular Imaging, 2(5), 527-534. doi: 10.1016/j.jcmg.2009.01.012 Schouten, B. J., Doogue, M. P., Soule, S. G., & Hunt, P. J. (2009). Iron polymaltose-induced FGF23 elevation complicated by hypophosphataemic osteomalacia. Annals of Clinical Biochemistry, 46(2), 167-169. doi: 10.1258/acb.2008.008151 Schouten, B. J., Hunt, P. J., Livesey, J. H., Frampton, C. M., & Soule, S. G. (2009). FGF23 elevation and hypophosphataemia after intravenous iron polymaltose: A prospective study. Journal of Clinical Endocrinology and Metabolism, 94, 2332-2337. doi: 10.1210/jc.2008-2396 Schultz, M., Gearry, R., Walmsley, R., Day, A. S., Fraser, A., Wyeth, J., Barclay, M., Clover, G., & Whiteside, C. (2010). New Zealand Society of Gastroenterology statement on the use of biological therapy in inflammatory bowel disease. New Zealand Medical Journal, 123(1314). Retrieved from http://www.nzma.org.nz/journal/archive.php Scott, N. J. A., Ellmers, L. J., Lainchbury, J. G., Maeda, N., Smithies, O., Richards, A. M., & Cameron, V. A. (2009). Influence of natriuretic peptide receptor-1 on survival and cardiac hypertrophy during development. Biochimica et Biophysica Acta, 1792(12), 1175-1184. doi: 10.1016/j.bbadis.2009.09.009 Scott, R. S., O’Brien, R., Fulcher, G., Pardy, C., d’Emden, M., Tse, D., et al. (2009). Effects of fenofibrate treatment on cardiovascular disease risk in 9,795 individuals with type 2 diabetes and various components of the metabolic syndrome. Diabetes Care, 32(3), 493-498. doi: 10.2337/dc08-1543 Scott-Thomas, A. J., Syhre, M., Pattemore, P. K., Epton, M., Laing, R., Pearson, J., & Chambers, S. T. (2010). 2-Aminoacetophenone as a potential breath biomarker for Pseudomonas aeruginosa in the cystic fibrosis lung. BMC Pulmonary Medicine, 10, 56. Retrieved from http://www.biomedcentral.com/1471-2466/10/56

224 RESEARCH REPORT 2009/2010 Seeley, M. J., Hu, W-P., Scotter, J. M., Storer, M. K., & Shaw, G. M. (2009). In vitro SIFT-MS validation of a breath fractionating device using a model VOC and ventilation system. Journal of Breath Research, 3(1), 016001. doi: 10.1088/1752- 7155/3/1/016001 Seeley, M., & Stevenson, D. S. (2009). ²Waste not, want not²: Making better use of house officers in the Otolaryngology Department at Christchurch Hospital, New Zealand. New Zealand Medical Journal, 122(1292). Retrieved from http://www. nzma.org.nz/journal/archive.shtml Shand, B. I., Scott, R. S., Lewis, J. G., Elder, P. A., & Frampton, C. M. (2009). Comparison of indices of insulin resistance with metabolic syndrome classifications to predict the development of impaired fasting glucose in overweight and obese subjects: A 3-year prospective study. International Journal of Obesity, 33(11), 1274-1279. doi: 10.1038/ijo.2009.169 Sharp, C. F., Gardiner, S. J., Jensen, B. P., Roberts, R. L., Troughton, R. W., Lainchbury, J. G., & Begg, E. J. (2009). CYP2D6 genotype and its relationship with metoprolol dose, concentrations and effect in patients with systolic heart failure. Pharmacogenomics Journal, 9(3), 175-184. doi: 10.1038/tpj.2009.9 Sheehan, D., Thwaites, J., & Abbott, S. (2010). A needs based simulation curriculum to bridge the trainee intern and postgraduate year one house officer years. International Journal of Clinical Skills, 4(1). Retrieved from http://www.ijocs. org/issues/vol4iss1.aspx Sheehan, D., & Wilkinson, T. J. (2010). Who’s going to move first? Practice guidelines for clinical supervision. Focus on Health Professional Education, 12(2), 14-29. Shrestha, K., Troughton, R. W., Borowski, A. G., Yandle, T. G., Richards, A. M., Klein, A. L., & Tang, W. H. W. (2010). Plasma corin levels provide minimal prognostic utility incremental to natriuretic peptides in chronic systolic heart failure. Journal of Cardiac Failure, 16(8), 621-627. doi: 10.1016/j.cardfail.2010.03.010 Silvers, K. M., Frampton, C. M., Wickens, K., Epton, M. J., Pattemore, P. K., Ingham, T., Fishwick, D., Crane, J., Town, G. I., & New Zealand Asthma and Allergy Cohort Study Group (2009). Breastfeeding protects against adverse respiratory outcomes at 15 months of age. Maternal and Child Nutrition, 5(3), 243-250. doi: 10.1111/j.1740-8709.2008.00169.x Simes, J., Voysey, M., O’Connell, R., Glasziou, P., Best, J. D., Scott, R., et al. (2010). A novel method to adjust efficacy estimates for uptake of other active treatments in long-term clinical trials. PLoS ONE, 5(1), e8580. doi: 10.1371/journal. pone.0008580 Simms, L. A., Doecke, J. D., Roberts, R. L., ..., Barclay, M. L., Gearry, R. B., Merriman, T. R., Montgomery, G. W., & Radford- Smith, G. L. (2010). KCNN4 gene variant is associated with ileal Crohn’s disease in the Australian and New Zealand population. American Journal of Gastroenterology, Advance Online Publication. doi: 10.1038/ajg.2010.161 Siriwardena, M., Kleffmann, T., Ruygrok, P., Cameron, V. A., Yandle, T. G., Nicholls, M. G., Richards, A. M., & Pemberton, C. J. (2010). B-type natriuretic peptide signal peptide circulates in human blood. Evaluation as a potential biomarker of cardiac ischemia. Circulation, 122, 255-264. doi: 10.1161/CIRCULATIONAHA.109.909937 Smith, A., Palmer, S., Johnson, D. W., Navaneethan, S., Valentini, M., & Strippoli, G. F. M. (2010). How to conduct a randomized trial. Nephrology, 15(8), 740-746. doi: 10.1111/j.1440-1797.2010.01433.x Snow, B. J., Rolfe, F. L., Lockhart, M. M., Frampton, C. M., ..., Smith, R. A. J., et al. (2010). A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson’s disease. Movement Disorders, 25(11), 1670-1674. doi: 10.1002/mds.23148 Stamp, L. K., Chapman, P. T., O’Donnell, J. L., Zhang, M., James, J., Frampton, C., Barclay, M. L., Kennedy, M. A., & Roberts, R. L. (2010). Polymorphisms within the folate pathway predict folate concentrations but are not associated with disease activity in rheumatoid arthritis patients on methotrexate. Pharmacogenetics and Genomics, 20(6), 367-376. doi: 10.1097/ FPC.0b013e3283398a71 Stamp, L. K., Easson, A., Pettersson, L., Highton, J., & Hessian, P. A. (2009). Monocyte derived interleukin (IL)-23 is an important determinant of synovial IL-17A expression in rheumatoid arthritis. Journal of Rheumatology, 36(11), 2403- 2408. doi: 10.3899/jrheum.081304 Stamp, L. K., O’Donnell, J. L., Chapman, P. T., Zhang, M., Frampton, C., James, J., & Barclay, M. L. (2009). Determinants of red blood cell methotrexate polyglutamate concentrations in rheumatoid arthritis patients receiving long-term methotrexate treatment. Arthritis & Rheumatism, 60(8), 2248-2256. doi: 10.1002/art.24653 Stamp, L. K., O’Donnell, J. L., Chapman, P. T., Zhang, M., James, J., Frampton, C., & Barclay, M. L. (2010). Methotrexate polyglutamate concentrations are not associated with disease control in rheumatoid arthritis patients receiving long-term methotrexate therapy. Arthritis and Rheumatism, 62(2), 359-368. doi: 10.1002/art.27201 Stamp, L. K., O’Donnell, J. L., Zhang, M., James, J., Frampton, C., Barclay, M. L., & Chapman, P. T. (2010). Using allopurinol above the dose based on creatinine clearance is effective and safe in chronic gout, including in those with renal impairment. Arthritis & Rheumatism, Advance Online Publication. doi: 10.1002/art.30119 Stamp, L. K., Zhu, X., Dalbeth, N., Jordan, S., Edwards, N. L., & Taylor, W. (2010). Serum urate as a soluble biomarker in chronic gout: Evidence that serum urate fulfills the OMERACT validation criteria for soluble biomarkers. Seminars in Arthritis and Rheumatism, Advance Online Publication. doi: 10.1016/j.semarthrit.2010.09.003 Stewart, L. C., Day, A. S., Pearson, J., Barclay, M. L., Gearry, R. B., Roberts, R. L., & Bentley, R. W. (2010). SLC11A1 polymorphisms in inflammatory bowel disease and Mycobacterium avium subspecies paratuberculosis status. World Journal of Gastroenterology, 16(45), 5727-5731. doi: 10.3748/wjg.v16.i45.5727 Sundaresan, A., Yuta, T., Hann, C. E., Chase, J. G., & Shaw, G. M. (2009). A minimal model of lung mechanics and model- based markers for optimizing ventilator treatment in ARDS patients. Computer Methods and Programs in Biomedicine, 95(2), 166-180. doi: 10.1016/j.cmpb.2009.02.008

Division of HEALTH SCIENCES 225 Tang, W. H. W., Shrestha, K., Martin, M. G., Borowski, A. G., Jasper, S., Yandle, T. G., Richards, A. M., Klein, A. L., & Troughton, R. W. (2010). Clinical significance of endogenous vasoactive neurohormones in chronic systolic heart failure. Journal of Cardiac Failure, 16(8), 635-640. doi: 10.1016/j.cardfail.2010.03.011 Taylor, B. V., Pearson, J. F., Clarke, G., Mason, D. F., Abernethy, D. A., Willoughby, E., & Sabel, C. (2010). MS prevalence in New Zealand, an ethnically and latitudinally diverse country. Multiple Sclerosis, 16(12), 1422-1431. doi: 10.1177/1352458510379614 Taylor, R. W., Williams, S. M., Grant, A. M., Taylor, B. J., & Goulding, A. (2010). Predictive ability of waist-to-height in relation to adiposity in children is not improved with age and sex-specific values. Obesity, Advance Online Publication. doi: 10.1038/oby.2010.217 Tebbutt, N. C., Wilson, K., Gebski, V. J., ..., Robinson, B., et al. (2010). Capecitabine, bevacizumab, and mitomycin in first-line treatment of metastic colorectal cancer: Results of the Australasian Gastrointestinal Trials Group randomized phase III MAX study. Journal of Clinical Oncology, 28(19), 3191-3198. doi: 10.1200/JCO.2009.27.7723 Than, M. P., Helm, J., Calder, K., Ardagh, M. W., Smith, M., Flaws, D. F., & Beckert, L. (2009). Comparison of high specificity with standard versions of a quantative latex D-dimer test in the assessment of community pulmonary embolism HaemosIL D-dimer HS and Pulmonary Embolism. Thrombosis Research, 124, 230-235. doi: 10.1016/j. thromres.2008.10.018 The Australia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene), including Clarke, G., McCallum, R., Merriman, M., Merriman, T., & Mason, D. (2009). Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. Nature Genetics, 41(7), 824-828. doi: 10.1038/ng.396 Ting, Y. T., Coates, T. P., Marti, H. P., Dunn, A. C., Parker, R. M., Pickering, J. W., Jack, R. W., Kemp, R. A., Walker, R. J., & McLellan, A. D. (2010). Urinary soluble HLA-DR is a potential biomarker for acute renal transplant rejection. Transplantation, 89(9), 1071-1078. doi: 10.1097/TP.0b013e3181d15492 Triggs, C. M., Munday, K., Hu, R., Fraser, A. G., Gearry, R. B., Barclay, M. L., & Ferguson, L. R. (2010). Dietary factors in chronic inflammation: Food tolerances and intolerances of a New Zealand Caucasian Crohn’s disease population. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 690, 123-138. doi: 10.1016/j. mrfmmm.2010.01.020 Troughton, R. W., Lewis, L. K., Yandle, T. G., Pemberton, C. J., & Nicholls, M. G. (2010). B-type natriuretic peptides: Looking to the future. Annals of Medicine, Advance Online Publication. doi: 10.3109/07853890.2010.526630 Troughton, R. W., & Richards, A. M. (2009). B-type natriuretic peptides and echocardiographic measures of cardiac structure and function. JACC: Cardiovascular Imaging, 2(2), 216-225. doi: 10.1016/j.jcmg.2008.12.006 Tweed, M., & Wilkinson, T. (2009). A randomized controlled trial comparing instructions regarding unsafe response options in a MCQ examination. Medical Teacher, 31(1), 51-54. doi: 10.1080/01421590802146018 van Asseldonk, D. P., Sanderson, J., ..., Gearry, R. B., Mulder, C. J., Mantzaris, G., van Bodegraven, A. A., & Thiopurine Task Force Interest Group (2010). Difficulties and possibilities with thiopurine therapy in inflammatory bowel disease— Proceedings of the first Thiopurine Task Force Meeting. Digestive and Liver Disease, Advance Online Publication. doi: 10.1016/j.dld.2010.09.001 van Dalen, C. J., Aldridge, R. E., Chan, T., Senthilmohan, R., Hancox, R. J., Cowan, J. O., Taylor, D. R., Town, G. I., & Kettle, A. J. (2009). Bromotyrosines in sputum proteins and treatment effects of terbutaline and budesonide in asthma. Annals of Allergy Asthma & Immunology, 103(4), 348-353. van Langenberg, D. R., Gearry, R. B., Wong, H-L., Ward, M., & Gibson, P. R. (2010). The potential value of fecal lactoferrin as a screening test in hospitalized patients with diarrhea. Internal Medicine Journal, Advance Online Publication. doi: 10.1111/j.1445-5994.2009.02102.x van Stockum, S., MacAskill, M. R., & Anderson, T. J. (2010). Bottom-up effects modulate saccadic latencies in well-known eye movement paradigm. Psychological Research, Advance Online Publication. doi: 10.1007/s00426-010-0305-4 Venn, B. J., Perry, T., Green, T. J., Skeaff, M., Aitken, W., Moore, N. J., Mann, J. I., Wallace, A. J., Monro, J., Bradshaw, A., Brown, R. C., Skidmore, P. M. L., Doel, K., O’Brien, K., Frampton, C., & Williams, S. (2010). The effect of increasing consumption of pulses and wholegrains in obese people: A randomized controlled trial. Journal of the American College of Nutrition, 29(4), 365-372. Volkova, E., Willis, J. A., Wells, J. E., Robinson, B. A., Dachs, G. U., & Currie, M. J. (2010). Association of angiopoietin-2, C-reactive protein and markers of obesity and insulin resistance with survival outcome in colorectal cancer. British Journal of Cancer, Advance Online Publication. doi: 10.1038/sj.bjc.6606005 Walker, J., Kelly, P., & Beckert, L. (2010). Airline policies for passengers with obstructive sleep apnoea who require in-flight continuous positive airways pressure. Respirology, 15, 556-561. doi: 10.1111/j.1440-1843.2010.01716.x Walker, J., Kelly, P. T., & Beckert, L. (2009). Airline policy for passengers requiring supplemental in-flight oxygen. Respirology, 14(4), 589-594. doi: 10.1111/j.1440-1843.2009.01521.x Wallace, A., Eady, S., Miles, M., Martin, H., McLachlan, A., Rodier, M., Willis, J., Scott, R., & Sutherland, J. (2010). Demonstrating the safety of manuka honey UMFÒ 20+ in a human clinical trial with healthy individuals. British Journal of Nutrition, 103(7), 1023-1028. doi: 10.1017/S0007114509992777 Wallace, A. J., Eady, S. L., Willis, J. A., Scott, R. S., Monro, J. A., & Frampton, C. M. (2009). Variability in measurements of blood glucose response to foods in human subjects is not reduced after a standard breakfast. Nutrition Research, 29(4), 238-243. doi: 10.1016/j.nutres.2009.03.003

226 RESEARCH REPORT 2009/2010 Wan Taib, W. R., Smyth, D. J., Merriman, M. E., Dalbeth, N., Gow, P. J., Harrison, A. A., Highton, J., Jones, P. B. B., Stamp, L., Steer, S., Todd, J. A., & Merriman, T. R. (2010). The PTPN22 locus and rheumatoid arthritis: No evidence for an effect on risk independent of Arg620Trp. PLoS ONE, 5(10), e13544. doi: 10.1371/journal.pone.0013544 Watson, S., Zhang, Z. K., & Wilkinson, T. J. (2010). Nutrition risk screening in community-living older people attending medical or falls prevention services. Nutrition & Dietetics, 67(2), 84-89. doi: 10.1111/j.1747-0080.2010.01424.x Webb, A., Knott, A., & MacAskill, M. R. (2010). Eye movements during transitive action observation have sequential structure. Acta Psychologica, 133, 51-56. doi: 10.1016/j.actpsy.2009.09.001 Webster, C. S., Larsson, L., Frampton, C. M., Weller, J., McKenzie, A., Cumin, D., & Merry, A. F. (2010). Clinical assessment of a new anaesthetic drug administration system: A prospective, controlled, longitudinal incident monitoring study. Anaesthesia, 65(5), 490-499. doi: 10.1111/j.1365-2044.2010.06325.x Weersma, R. K., Crusius, J. B. A., Roberts, R. L., Koeleman, B. P. C., Palomino-Morales, R., Wolfkamp, S., Hollis-Moffatt, J. E., ..., Gearry, R. B., Barclay, M. L., ..., Merriman, T. R., et al. (2010). Association of FcgR2a, but not FcgR3a, with inflammatory bowel diseases across three Caucasian populations. Inflammatory Bowel Diseases, 16(12), 2080-2089. doi: 10.1002/ibd.21342 White, D. H. N., Chapman, P. T., O’Donnell, J. L., James, J., Frampton, C., & Stamp, L. K. (2010). Lack of association between elevated mean red cell volume and haematological toxicity in patients receiving long-term methotrexate for rheumatoid arthritis. Internal Medicine Journal, 40(8), 561-565. doi: 10.1111/j.1445-5994.2009.02059.x Whitehead, C., Lunt, H., Pearson, J. F., & Cawood, T. J. (2010). Is screening for hypothyroidism in the diabetes clinic effective? Practical Diabetes International, 27(3), 113-117. doi: 10.1002/pdi.1458 Wickens, K., Beasley, R., Town, G. I., Epton, M., Pattemore, P., Ingham, T., Crane, J., & New Zealand Asthma and Allergy Cohort Study Group (2010). The effects of early and late paracetamol exposure on asthma and atopy: A birth cohort. Clinical & Experimental Allergy, Advance Online Publication. doi: 10.1111/j.1365-2222.2010.03610.x Wiles, J. L., Allen, R. E. S., Palmer, A. J., Hayman, K. J., Keeling, S., & Kerse, N. (2009). Older people and their social spaces: A study of well-being and attachment to place in Aotearoa New Zealand. Social Science and Medicine, 68(4), 664-671. doi: 10.1016/j.socscimed.2008.11.030 Wilkinson, T. J. (2010). Scholarship in health professional education organisations: Creating a community of scholars. Focus on Health Professional Education, 11(3), 33-41. Wilkinson, T. J., D’Orsogna, L. J., Nair, B. R., Judd, S. J., & Frampton, C. M. (2009). The reliability of long and short cases undertaken as practice for a summative examination. Internal Medicine Journal, (Accepted article). doi: 10.1111/j.1445- 5994.2009.01970.x Wilkinson, T. J., Wade, W. B., & Knock, L. D. (2009). A blueprint to assess professionalism: Results of a systematic review. Academic Medicine, 84(5), 551-558. doi: 10.1097/ACM.0b013e31819fbaa2 Wilkinson, T. J., Weller, J. M., McKimm, J., O’Connor, B. J., ..., Tweed, M. J., & Wearn, A. M. (2010). Programmatic research in New Zealand medical education: A national collaboration. New Zealand Medical Journal, 123(1318). Retrieved from http://www.nzma.org.nz/journal/123-1318/4210/ Wong, J. S. J., Schousboe, M. I., Metcalf, S. S. L., Endre, Z. H., Hegarty, J. M., Maze, M. J., Keith, E. R., Seaward, L. M., & Podmore, R. G. (2010). Ochroconis gallopava peritonitis in a cardiac transplant patient on continuous ambulatory peritoneal dialysis [Case report]. Transplant Infectious Disease, 12(5), 455-458. doi: 10.1111/j.1399-3062.2010.00523.x Wong, X-W., Chase, J. G., Le Compte, A. J., Hann, C. E., Lin, J., & Shaw, G. M. (2009). An adaptive clinical Type 1 diabetes control protocol to optimize conventional self-monitoring blood glucose and multiple daily-injection therapy. International Journal of Adaptive Control and Signal Processing, 23(5), 408-434. doi: 10.1002/acs.1069 Wright, D. F. B., & Begg, E. J. (2010). The ‘apparent clearance’ of free phenytoin in elderly vs. younger adults. British Journal of Clinical Pharmacology, 70(1), 132-138. doi: 10.1111/j.1365-2125.2010.03673.x Wright, S. P., Doughty, R. N., Frampton, C. M., Gamble, G. D., Yandle, T. G., & Richards, A. M. (2009). Plasma urocortin 1 in human heart failure. Circulation-Heart Failure, 2(5), 465-471. doi: 10.1161/circheartfailure.108.840207 Wu, C. C., Fairhall, S. L., McNair, N. A., Hamm, J. P., Kirk, I. J., Cunnington, R., Anderson, T., & Lim, V. K. (2010). Impaired sensorimotor integration in focal hand dystonia patients in the absence of symptoms. Journal of Neurology, Neurosurgery and Psychiatry, 81(6), 659-665. doi: 10.1136/jnnp.2009.185637 Wyber, R., Wilson, N., & Baker, M. (2009). New Zealand’s impact on health in the South Pacific: Scope for improvement? New Zealand Medical Journal, 122(1291). Retrieved from http://www.nzma.org.nz/journal/122-1291/3505/ Young, R. P., Hopkins, R. J., Hay, B. A., Epton, M. J., Mills, G. D., Black, P. N., Gardner, H. D., Sullivan, R., & Gamble, G. D. (2009). Lung cancer susceptibility model based on age, family history and genetic variants. PLoS ONE, 4(4), e5302. doi: 10.1371/journal.pone.0005302 Young, R. P., Hopkins, R. J., Hay, B. A., Epton, M. J., Mills, G. D., Black, P. N., Gardner, H., Sullivan, R., & Gamble, G. D. (2009). A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers. Postgraduate Medical Journal, 85(1008), 515-524. doi: 10.1136/pgmj.2008.077107 Young, R. P., Whittington, C. F., Hopkins, R. J., Hay, B. A., Epton, M. J., Black, P. N., & Gamble, G. D. (2010). Chromosome 4q31 locus in COPD is also associated with lung cancer. European Respiratory Journal, 36(6), 1375-1382. doi: 10.1183/09031936.00033310 Zhang, M., Moore, G. A., Barclay, M. L., & Begg, E. J. (2009). Determination of perhexiline and its metabolite hydroxyperhexiline in human plasma by liquid chromatography/tandem mass spectrometry. Journal of Chromatography B, 877(27), 3025-3030. doi: 10.1016/j.jchromb.2009.07.021

Division of HEALTH SCIENCES 227 Zhang, M., Moore, G., Jensen, B. P., Begg, E. J., & Bird, P. A. (2010). Determination of dexamethasone and dexamethasone sodium phosphate in human plasma and cochlear perilymph by liquid chromatography/tandem mass spectrometry. Journal of Chromatography B, Advance Online Publication. doi: 10.1016/j.jchromb.2010.11.003

Journal - Research Other Bagg, W., ..., Reid, J. J., Rudland, J., Tweed, M. J., & Wilkinson, T. J. (2010). Setting up new learning environments in regional and rural areas. New Zealand Medical Journal, 123(1312). Retrieved from http://www.nzma.org.nz/journal/123-1312/4061/ Barber, P. A., Tippett, L. J., Frampton, C., & Milsom, P. (2009). Postoperative ischemia and cognitive impairment in cardiac surgery patients [Letter to the editor]. Annals of Thoracic Surgery, 87(2), 672-673. doi: 10.1016/j.athoracsur.2008.05.021 Bridgman, P. G. (2009). [Review of the book Complications of myocardial infarction]. New Zealand Medical Journal, 122(1294). Retrieved from http://www.nzma.org.nz/journal/archive/php Bridgman, P. G., & Ali, A. (2009). Leap of faith: From knowledge to safe practice [Editorial]. New Zealand Medical Journal, 122(1292). Bryant, D. L., Miles, C. J., & Gearry, R. B. (2010). Nodular regenerative hyperplasia of the liver secondary to azathioprine in a patient with inflammatory bowel disease [Case report]. New Zealand Medical Journal, 123(1313). Retrieved from http:// www.nzma.org.nz/journal/archive.shtml Cawood, T. J., Bridgman, P., Hunter, L., & Cole, D. (2009). Low-dose cabergoline causing valvular heart disease in a patient treated for prolactinoma [Letter to the editor]. Internal Medicine Journal, 39, 266-267. doi: 10.1111/j.1445- 5994.2009.01920.x Chen, H. K., Jardine, D., & Beckert, L. (2009). Orthopnoea and arm weakness. Thorax, 64(12), 1031. doi: 10.1136/ thx.2009.121632 Chieng, J. H. C., Garrett, J., Ding, S. L., & Sullivan, M. (2009). Clinical presentation and endoscopic features of primary gastric Burkitt lymphoma in childhood, presenting as a protein-losing enteropathy: A case report. Journal of Medical Case Reports, 3, 72. doi: 10.4076/1752-1947-3-7256 Cole, D. (2010). [Review of the book Decision making in medicine: An algorithmic approach (3rd edition)]. New Zealand Medical Journal, 123(1326). Retrieved from http://www.nzma.org.nz/journal/123-1326/4456/content.pdf Daly, M. G., Frampton, C. M., & Troughton, R. W. (2010). Improving risk stratification for heart failure: A role for serial testing of B-type natriuretic peptides? [Editorial comment]. Journal of the American College of Cardiology, 55(5), 451-453. doi: 10.1016/j.jacc.2009.08.060 Evans, C., Chalmers-Watson, T. A., & Gearry, R. B. (2010). Combination NSAID-codeine preparations and gastrointestinal toxicity [Clinical correspondence]. New Zealand Medical Journal, 123(1324). Retrieved from http://www.nzma.org.nz/ journal/123-1324/4383/content.pdf Florkowski, C., Molyneux, S., George, P., Lever, M., & Richards, M. (2009). N-3 polyunsaturated fatty acids and statins in heart failure [Letter]. Lancet, 373(9661), 379-380. doi: 10.1016/S0140-6736(09)60129-X Gearry, R. B., Day, A. S., Barclay, M. L., Leong, R. W. L., & Sparrow, M. P. (2010). Azathioprine and allopurinol: A two-edged interaction [Editorial]. Journal of Gastroenterology and Hepatology, 25(4), 653-655. doi: 10.1111/j.1440-1746.2010.06254.x Gearry, R. B., & Irving, P. M. (2009). Biologics for inflammatory bowel diseases in the Asia-Pacific: Can we afford to use them, can we afford not to? [Editorial]. Journal of Gastroenterology and Hepatology, 24(7), 1160-1162. doi: 10.1111/j.1440- 1746.2009.05896.x Gibson, P. R., & Gearry, R. B. (2010). Optimizing thiopurine therapy: More weight to the metabolite argument [Editorial]. Journal of Gastroenterology and Hepatology, 25(10), 1592-1594. doi: 10.1111/j.1440-1746.2010.06472.x Hamilton, N., & Beckert, L. (2010). Dr Nathan Tucker’s Asthma Specific: A treatment for asthma preceding inhaled steroids and beta-agonists. New Zealand Medical Journal, 123(1323). Retrieved from http://www.nzma.org.nz/ journal/123-1323/4364/content.pdf Hanger, H. C. (2009). Changes to health service delivery: Success and pitfalls [Letter]. New Zealand Medical Journal, 122(1306). Retrieved from http://www.nzma.org.nz/journal/archive.php Hanger, H. C. (2009). The effect of bedrails on falls and injury [Letter to the editor]. Age and Ageing, 38(3), 355. doi: 10.1093/ ageing/afp027 Harrington, C., James, M., & Wynne, C. (2010). Radiation myelopathy after 36 Gy in 12 fractions palliative chest radiotherapy for squamous cell cancer of the lung: Case report and review of published studies. Clinical Oncology, 22, 561-563. doi: 10.1016/j.clon.2010.05.015 Heppenstall, C. P., Wilkinson, T. J., Hanger, H. C., & Keeling, S. (2009). Frailty: Dominos or deliberation? New Zealand Medical Journal, 122(1299). Retrieved from http://www.nzma.org.nz/journal/122-1299/3710/ Hollis-Moffatt, J. E., Gearry, R. B., Barclay, M. L., Merriman, T. R., & Roberts, R. L. (2010). Consolidation of evidence for association of the KIAA1109-TENR-IL2-IL21 rs6822844 variant with Crohn’s disease [Letter]. American Journal of Gastroenterology, 105(5), 1204-1205. doi: 10.1038/ajg.2010.34 Huelsen-Katz, A. M., Schouten, B. J., Jardine, D. L., Soule, S. G., & Liu, H. (2010). Pictorial evolution of bilateral adrenal haemorrhage [Letter to the editor]. Internal Medicine Journal, 40(1), 87-88. doi: 10.1111/j.1445-5994.2009.02117.x Keeling, S. (2009). [Review of the book Rural ageing: A good place to grow old?]. Ageing & Society, 29, 159-160. doi: 10.1017/ s0144686x08007897 Kennedy, B., & Beckert, L. (2010). A case of acupuncture-induced pneumothorax. New Zealand Medical Journal, 123(1320). Retrieved from http://www.nzma.org.nz/journal/123-1320/4258/content.pdf

228 RESEARCH REPORT 2009/2010 Khan, E. A. R., Blake, J. W. H., & Stamp, L. K. (2009). Ticlopidine as a safe alternative for clopidogrel-associated arthritis [Letter to the editor]. Journal of Rheumatology, 36(4), 855-856. doi: 10.3899/jrheum.081131 Kong, V., Beckert, L., & Awunor-Renner, C. (2009). A case of beta lactam-induced visual hallucination. New Zealand Medical Journal, 122(1298). Retrieved from http://www.nzma.org.nz/journal/122-1298/3689/content.pdf Macdonald, C. A., Jardine, D. L., Hurrell, M. A., & Pithie, A. D. (2009). The worm that turned [Case report]. Transactions of the Royal Society of Tropical Medicine and Hygiene, 103(10), 1065-1067. doi: 10.1016/j.trstmh.2009.05.007 Mackenzie, K. A., Simcock, J. W., Lainchbury, J. G., Currie, M. J., & Lynn, K. L. (2009). Myocardial metastasis of cutaneous squamous cell carcinoma in a renal transplant recipient [Case report]. Transplantation Proceedings, 41(10), 4414-4415. doi: 10.1016/j.transproceed.2009.09.056 McKimm, J., Wilkinson, T., Poole, P., & Bagg, W. (2010). The current state of undergraduate medical education in New Zealand. Medical Teacher, 32(6), 456-460. doi: 10.3109/0142159x.2010.486427 Navaneethan, S. D., Palmer, S. C., Schreiber, M. J., & Strippoli, G. F. M. (2009). Weighing the evidence for treatment of chronic kidney disease mineral and bone disorder. Nephrology, 14(4), 363-366. doi: 10.1111/j.1440-1797.2009.01151.x Newnham, E., Gearry, R., & Gibson, P. (2010). Factors associated with radiation exposure in patients with inflammatory bowel disease [Letter to the editor]. Alimentary Pharmacology & Therapeutics, 31, 534-535. doi: 10.1111/j.1365- 2036.2009.04205.x Parekh, K., Ching, D., Rahman, M. U., & Stamp, L. K. (2010). Onset of Wegener’s granulomatosis during therapy with golimumab for rheumatoid arthritis: A rare adverse event? (Case Report) [Letter to the editor]. Rheumatology, 49(9), 1785-1787. doi: 10.1093/rheumatology/keq101 Phipps-Green, A. J., Topless, R. K. G., Merriman, M. E., Dalbeth, N., Gow, P. J., Harrison, A. A., Highton, J., Jones, P. B. B., Stamp, L. K., Harrison, P., Wordsworth, B. P., & Merriman, T. R. (2009). No evidence for association of the systemic lupus erythematosus-associated ITGAM variant, R77H, with rheumatoid arthritis in the Caucasian population [Letter to the editor]. Rheumatology, 48(12), 1614-1615. doi: 10.1093/rheumatology/kep254 Pickering, J. W., & Endre, Z. H. (2009). GFR shot by RIFLE: Errors in staging acute kidney injury. Lancet, 373(9672), 1318-1319. Richards, A. M. (2010). C-type natriuretic peptide and cardiac fibrosis [Editorial]. Hypertension, 57, 154-155. doi: 10.1161/ HYPERTENSIONAHA.110.163865 Richards, A. M. (2010). Nuevos biomarcadores en la insuficiencia cardiaca: Aplicaciones en el diagnóstico, pronóstico y pautas de tratamiento [Editorial]. Revista Espanola de Cardiologia, 63(6), 635-639. doi: 10.1016/S0300-8932(10)70155-X Roberts, R. L., Gearry, R. B., & Barclay, M. L. (2010). Allopurinol—thiopurine combination therapy in inflammatory bowel disease: Are there genetic clues to this puzzle? [Editorial]. Pharmacogenomics, 11(11), 1505-1508. doi: 10.2217/pgs.10.143 Roberts, R. L., Zhang, M., Marinaki, A. M., & Stamp, L. K. (2010). Does genetic variability in aldehyde oxidase and molybdenum cofactor sulfurase predict nonresponse to allopurinol? [Letter to the editors]. Alimentary Pharmacology & Therapeutics, 32(2), 310-311. doi: 10.1111/j.1365-2036.2010.04349.x Robinson, B. (2010). [Review of the book Ethical issues in governing biobanks: Global perspectives]. New Zealand Medical Journal, 123(1327). Retrieved from http://www.nzma.org.nz/journal/123-1327/4490/content.pdf Robinson, L., McKellar, M., Fitzharris, B., & Elder, M. (2009). Topical mitomycin C for the local treatment of a primary diffuse large B-cell lymphoma of the palpebral conjunctiva [Letter to the editor]. Clinical and Experimental Ophthalmology, 37(9), 891-892. doi: 10.1111/j.1442-9071.2009.02173.x Sheehan, D., Bagg, W., de Beer, W., Child, S., Hazell, W., Rudland, J., & Wilkinson, T. J. (2010). The good apprentice in medical education. New Zealand Medical Journal, 123(1308). Retrieved from http://www.nzma.org.nz/journal/archive.php Shute, A., & Beckert, L. (2009). Induced sputum or bronchoscopy in the detection of pulmonary tuberculosis? New Zealand Medical Journal, 122(1305). Retrieved from http://www.nzma.org.nz/journal/122-1305/3856/content.pdf Stamp, L. K., & Hurst, M. (2010). Is there a role for consensus guidelines for P. jiroveci pneumonia prophylaxis in immunosuppressed patients with rheumatic diseases? [Editorial]. Journal of Rheumatology, 37(4), 686-688. doi: 10.3899/ jrheum.091426 Stamp, L. K., O’Donnell, J. L., Barclay, M. L., Frampton, C., & Chapman, P. T. (2010). Response to comments [Letter to the editor]. Arthritis and Rheumatism, 62(8), 2560-2561. doi: 10.1002/art.27539 Stamp, L. K., O’Donnell, J. L., Chapman, P. T., Barclay, M. L., Kennedy, M. A., Frampton, C. M. A., & Roberts, R. L. (2009). Lack of association between HLA-G 14 bp insertion/deletion polymorphism and response to longterm therapy with methotrexate response in rheumatoid arthritis [Letter]. Annals of the Rheumatic Diseases, 68(1), 154-155. doi: 10.1136/ ard.2008.089383 Troughton, R. W., Frampton, C. M., & Nicholls, M. G. (2010). Biomarker-guided treatment of heart failure: Still waiting for a definitive answer [Editorial Comment]. Journal of the American College of Cardiology, 56(25), 2101-2104. doi: 10.1016/j. jacc.2010.07.034 Tweed, M. J., Bagg, W., Child, S., Wilkinson, T. J., & Weller, J. M. (2010). How the trainee intern (TI) year can ease the transition from undergraduate education to postgraduate practice. New Zealand Medical Journal, 123(1318). Retrieved from http://www.nzma.org.nz/journal/archive.php Upton, J., & George, P. (2010). The prevalence of lactose intolerance (adult hypolactasia) in a randomly selected New Zealand population [Letter]. New Zealand Medical Journal, 123(1308). Retrieved from http://www.nzma.org.nz/ journal/123-1308/3970/content.pdf Weller, J. M., Thwaites, J., Boopathkar, H., & Hazell, W. (2010). Are doctors team players, and do they need to be? New Zealand Medical Journal, 123(1310). Retrieved from http://www.nzma.org.nz/journal/archive.shtml

Division of HEALTH SCIENCES 229 Yandle, T. G., & Troughton, R. W. (2010). Improving risk stratification in heart failure: A role for new biomarkers [Editorial]. European Journal of Heart Failure, 12, 315-318. doi: 10.1093/eurjhf/hfq030 Zhou, H., Frampton, C. M., & Hickford, J. G. H. (2009). Variation in ovine capn3 is not associated with meat tenderness [Brief note]. Animal Genetics, 40(2), 251-252. doi: 10.1111/j.1365-2052.2008.01827.x

Journal - Professional & Other Non-Research Articles Bernstein, C. N., Fried, M., Krabshuis, J. H., Cohen, H., Eliakim, R., Fedail, S., Gearry, R., et al. (2010). World Gastroenterology Organization practice guidelines for the diagnosis and management of IBD in 2010. Inflammatory Bowel Diseases, 16(1), 112-124. doi: 10.1002/ibd.21048 Chan, W. Y. W., McClean, D. R., Elliott, J. M., & MacDonald, S. (2009). CT coronary angiography to guide intervention for acute myocardial ischaemia in a patient with an anomalous single coronary ostium. Heart, Lung and Circulation, 18(6), 407-409. doi: 10.1016/j.hlc.2008.04.006 Chan, W. Y. W., Troughton, R. W., & Singh, H. (2009). Intracardiac slug. New Zealand Medical Journal, 122(1303). Retrieved from http://www.nzma.org.nz/journal/archive.shtml Dummer, J. F., & Taylor, D. R. (2010). Defining the role of exhaled nitric oxide measurements in COPD [Editorial]. Respirology, 15, 385-386. doi: 10.1111/j.1440-1843.2010.01730.x Finn, R. S., Beckert, L., & Troughton, R. (2009). Iloprost-induced rash. Thorax, 64(10), 917-918. doi: 10.1136/thx.2009.116111 McLachlan, C., & Beckert, L. (2010). [Review of the book Examination medicine: A guide to physician training (6th edition)]. New Zealand Medical Journal, 123(1315). Retrieved from http://www.nzma.org.nz/journal/123-1315/4145/content.pdf Palmer, S. C., Craig, J. C., & Strippoli, G. F. M. (2009). Taking aim at targets [Editorial comment]. Nephrology Dialysis Transplantation, 24(5), 1358-1361. doi: 10.1093/ndt/gfp025 Palmer, S. C., & Richards, A. M. (2009). Does renal clearance differ between the B-type natriuretic peptides (BNP versus NT-proBNP)? [Editorial comment]. Journal of the American College of Cardiology, 53(10), 891-892. doi: 10.1016/j. jacc.2008.11.031 Pickering, J. W., & Endre, Z. H. (2009). RIFLE and AKIN - maintain the momentum and the GFR! [Letter]. Critical Care, 13, 416. doi: 10.1186/cc8019 Richards, A. M. (2009). Therapeutic potential of infused cardiac natriuretic peptides in myocardial infarction [Editorial]. Heart, 95(16), 1299-1300. doi: 10.1136/hrt.2008.163857 Roberts, R. L., Merriman, T. R., & Upton, J. D. (2010). High frequency of MCM6 lactose intolerance genotype in Polynesian People [Letter to the editor]. Alimentary Pharmacology and Therapeutics, 32(6), 828-829. doi: 10.1111/j.1365- 2036.2010.04398.x Rudland, J., Bagg, W., Child, S., de Beer, W., Hazell, W., Poole, P., Sheehan, D., & Wilkinson, T. J. (2010). Maximising learning through effective supervision. New Zealand Medical Journal, 123(1309). Retrieved from http://www.nzma.org.nz/journal/ archive.shtml Taylor, D. R., & Dummer, J. (2010). Exhaled nitric oxide and COPD [Letter]. European Respiratory Journal, 36(3), 692. doi: 10.1183/09031936.00058310 Tweed, M., & Wilkinson, T. (2009). The seven deadly sins of assessment [Assessment]. Clinical Teacher, 6(3), 164-166. doi: 10.1111/j.1743-498X.2009.00293.x Tweed, M., & Wilkinson, T. (2010). Should there be borderline candidates or should there be a zone of uncertainty around assessment decisions? [Letter to the editor]. Medical Teacher, 32(10), 869. doi: 10.3109/0142159X.2010.524520 Wilkinson, T. (2009). A change to pass/fail grading [Letter to the editor]. Academic Medicine, 84(12), 1643. doi: 10.1097/ ACM.0b013e3181bee645

Commissioned Report for External Body Deering, D., Robinson, G., Wheeler, A., Pulford, J., Frampton, C., Dunbar, L., & Black, S. (2009). Preliminary work towards validating a draft outcome measure for use in the alcohol and drug sector. Auckland, New Zealand: Te Pau o te Whakaaro Nui, 70p.

Working Paper; Discussion Paper; Technical Report Davey, J., Keeling, S., & Zodgekar, A. (2010). Families, ageing and migration: Indian communities in Auckland, Wellington and Christchurch [Institute of Policy Studies Working Paper: No.10/03]. Wellington, New Zealand: Institute of Policy Studies, School of Government, Victoria University of Wellington. (pp. 1-29). Keeling, S., Davey, J., & Glasgow, K. (2009). Health, Work and Retirement Study: Summary report for the 2008 data wave: Qualitative interviews. (pp. 1-39). Retrieved from http://hwr.massey.ac.nz/publications.htm#summary

230 RESEARCH REPORT 2009/2010 University of Otago, Christchurch Department of Obstetrics and Gynaecology

Journal - Research Article Alkaisi, M. M., Muys, J. J., & Evans, J. J. (2009). Single cell imaging with AFM using Biochip/Bioimprint technology. International Journal of Nanotechnology, 6(3-4), 355-368. doi: 10.1504/IJNT.2009.022925 Anderson, G. M., Relf, H-L., Rizwan, M. Z., & Evans, J. J. (2009). Central and peripheral effects of RFamide-related peptide-3 on luteinizing hormone and prolactin secretion in rats. Endocrinology, 150(4), 1834-1840. doi: 10.1210/en.2008-1359 Dann, J. M., Sykes, P. H., Mason, D. R., & Evans, J. J. (2009). Regulation of Vascular Endothelial Growth Factor in endometrial tumour cells by resveratrol and EGCG. Gynecologic Oncology, 113(3), 374-378. Kuiper, C., Molenaar, I. G. M., Dachs, G. U., Currie, M. J., Sykes, P. H., & Vissers, M. C. M. (2010). Low ascorbate levels are associated with increased hypoxia-inducible factor-1 activity and an aggressive tumor phenotype in endometrial cancer. Cancer Research, 70(14), 5749-5758. doi: 10.1158/0008-5472.CAN-10-0263 Kyle, P. M., Coghlan, P., Matthews, J., de Ryke, R., & Reid, R. (2009). Accuracy of prenatal diagnosis in a tertiary fetal medicine unit. New Zealand Medical Journal, 122(1288). Retrieved from http://www.nzma.org.nz/journal/archive.php McEwing, R. L., Anderson, N. G., Meates, J. B. A., Allen, R. B., Phillipson, G. T. M., & Wells, J. E. (2009). Sonographic appearances of the endometrium after termination of pregnancy in asymptomatic versus symptomatic women. Journal of Ultrasound in Medicine, 28(5), 579-586. McLeod, M., Harris, R., Purdie, G., Cormack, D., Robson, B., Sykes, P., et al. (2010). Improving survival disparities in cervical cancer between Mäori and non-Mäori women in New Zealand: A National Retrospective Cohort Study. Australian and New Zealand Journal of Public Health, 34(2), 193-199. doi: 10.1111/j.1753-6405.2010.00506.x Obermair, A., Mileshkin, L., Bolz, K., ..., Sykes, P., & Janda, M. (2010). Prospective, non-randomized phase 2 clinical trial of carboplatin plus paclitaxel with sequential radical pelvic radiotherapy for uterine papillary serous carcinoma. Gynecologic Oncology, Advance Online Publication. doi: 10.1016/j.ygyno.2010.10.039 Pearson, L. J., Yandle, T. G., Nicholls, M. G., & Evans, J. J. (2009). Intermedin (Adrenomedullin-2): A potential protective role in human aortic endothelial cells. Cellular Physiology and Biochemistry, 23(1-3), 97-108. Peters, E. E. M., Towler, K. L., Mason, D. R., & Evans, J. J. (2009). Effects of galanin and leptin on gonadotropin-releasing hormone-stimulated luteinizing hormone release from the pituitary. Neuroendocrinology, 89(1), 18-26. Priest, P., Sadler, L., Sykes, P., Marshall, R., Peters, J., & Crengle, S. (2010). Determinants of inequalities in cervical cancer stage at diagnosis and survival in New Zealand. Cancer Causes and Control, 21, 209-214. doi: 10.1007/s10552-009-9451-7 Samsuri, F., Alkaisi, M. M., Mitchell, J. S., & Evans, J. J. (2010). Replication of cancer cells using soft lithography bioimprint technique. Microelectronic Engineering, 87, 699-703. doi: 10.1016/j.mee.2009.12.068 Smart, O. C., Sykes, P., McNab, H., & Jennings, L. (2010). Testing for high risk human papilloma virus in the initial follow-up of women treated for high-grade squamous intraepithelial lesions. Australian and New Zealand Journal of Obstetrics and Gynaecology, 50(2), 164-167. doi: 10.1111/j.1479-828X.2009.01132.x Tawfeek, S., & Scott, P. (2010). National inpatient diagnostic hysteroscopy survey. Gynecological Surgery, 7(1), 53-59. doi: 10.1007/s10397-009-0508-0 Wakeman, S., & Benny, P. (2009). Is it possible to predict a fertile cycle? Uteroovarian blood flow parameters in conception versus nonconception cycles. Fertility and Sterility, 91(6), 2726-2731. doi: 10.1016/j.fertnstert.2008.03.069

Journal - Research Other Badami, K. G., Vanhecke, C., & Bingham, J. (2009). Maternal IgM anti-D, borderline foetal Doppler middle cerebral artery velocities and absent neonatal haemolysis [Case report]. Transfusion Medicine, 19(3), 146-147. doi: 10.1111/j.1365- 3148.2009.00924.x Evans, J. J. (2009). Toward revealing the roles for intermedin in the community of vasoactive peptides. Hypertension Research, 32(10), 824-825. doi: 10.1038/hr.2009.127 Sykes, P., Miller, A., & Peddie, D. (2009). Unsatisfactory cervical cytology screening specimens are associated with missed cervical dysplasia and cancer [Author’s reply]. BJOG: An International Journal of Obstetrics and Gynaecology, 116(6), 867. doi: 10.1111/j.1471-0528.2009.02114.x

University of Otago, Christchurch Department of Orthopaedic Surgery and Musculoskeletal Medicine

Journal - Research Article Bogduk, N., MacVicar, J., & Borowczyk, J. (2010). The pain of vertebral compression fractures can arise in the posterior elements. Pain Medicine, 11(11), 1666-1673. doi: 10.1111/j.1526-4637.2010.00963.x Chey, M. H., Rodgers, G. W., Chase, J. G., & Mander, J. B. (2010). Using upper storeys as semi-active tuned mass damper building systems: A case study analysis. Bulletin of the New Zealand Society for Earthquake Engineering, 43(2), 126-133. Dalton, P. D., Woodfield, T., & Hutmacher, D. W. (2009). Snapshot: Polymer scaffolds for tissue engineering [biomaterials 30/4 (2009) 701-702]. Biomaterials, 30(4), 701-702. doi: 10.1016/j.biomaterials.2009.01.049

Division of HEALTH SCIENCES 231 Dunn, J. A., Hay-Smith, E. J. C., Whitehead, L. C., Keeling, S., & Rothwell, A. G. (2010). Upper limb reconstructive surgery uptake for persons with tetraplegia in New Zealand: A retrospective case review 2001-2005. Spinal Cord, Advance Online Publication. doi: 10.1038/sc.2010.15 Dunn, J., Sinnott, K. A., Nunnerley, J., & Scheuringer, M. (2009). Utilisation of patient perspective to validate clinical measures of outcome following spinal cord injury. Disability and Rehabilitation, 31(12), 967-975. Hooper, G. J., Hooper, N. M., Rothwell, A. G., & Hobbs, T. (2009). Bilateral total joint arthroplasty: The early results from the New Zealand National Joint Registry. Journal of Arthroplasty, 24(8), 1174-1177. doi: 10.1016/j/arth.2008.09.022 Hooper, G. J., Rothwell, A. G., Stringer, M., & Frampton, C. (2009). Revision following cemented and uncemented primary total hip replacement: A seven-year analysis from the New Zealand Joint Registry. Journal of Bone & Joint Surgery (Br), 91- B(4), 451-458. doi: 10.1302/0301-620X.91B4 Hooper, G., Rothwell, A., & Frampton, C. (2009). The low contact stress mobile-bearing total knee replacement: A prospective study with a minimum follow-up of ten years. Journal of Bone & Joint Surgery (Br), 91-B(1), 58-63. doi: 10.1302/0301-620X.91B1 Jaggi, A., Malone, A. A., Cowan, J., Lambert, S., Bayley, I., & Cairns, M. C. (2009). Prospective blinded comparison of surface versus wire electromyographic analysis of muscle recruitment in shoulder instability. Physiotherapy Research International, 14(1), 17-29. doi: 10.1002/pri.407 Kirkland, N. T., Birbilis, N., Walker, J., Woodfield, T., Dias, G. J., & Staiger, M. P. (2010). In-vitro dissolution of magnesium- calcium binary alloys: Clarifying the unique role of calcium additions in bioresorbable magnesium implant alloys. Journal of Biomedical Materials Research B: Applied Biomaterials, 95B(1), 91-100. doi: 10.1002/jbm.b.31687 Mohammed, K. D., Wilkinson, B., & Nagaraj, C. (2010). Can imaging determine if a rotator cuff tear is traumatic? New Zealand Medical Journal, 123(1327). Retrieved from http://www.nzma.org.nz/journal/123-1327/4470/content.pdf Mulligan, K. J., Chase, J. G., Mander, J. B., Rodgers, G. W., & Elliott, R. B. (2010). Nonlinear models and validation for resetable device design and enhanced force capacity. Structural Control and Health Monitoring, 17(3), 301-316. doi: 10.1002/stc.298 Pearse, A. J., Hooper, G. J., Rothwell, A., & Frampton, C. (2010). Survival and functional outcome after revision of a unicompartmental to a total knee replacement: The New Zealand National Joint Registry. Journal of Bone and Joint Surgery, 92(4), 508-512. doi: 10.1302/0301-620X.92B4.22659 Rodgers, G. W., Mander, J. B., & Chase, J. G. (2010). Semi-explicit rate-dependent modeling of damage-avoidance steel connections using HF2V damping devices. Earthquake Engineering and Structural Dynamics, Advance Online Publication. doi: 10.1002/eqe.1073 Rodgers, G. W., Solberg, K. M., Mander, J. B., Chase, J. G., Bradley, B. A., & Dhakal, R. P. (2010). High-force-to-volume seismic dissipators embedded in a jointed precast concrete frame. Journal of Structural Engineering, Advance Online Publication. doi: 10.1061/(ASCE)ST.1943-541X.0000329 Rothwell, A. G., Hooper, G. J., Hobbs, A., & Frampton, C. M. (2010). An analysis of the Oxford hip and knee scores and their relationship to early joint revision in the New Zealand Joint Registry. Journal of Bone and Joint Surgery (Br), 92B(3), 413- 418. doi: 10.1302/0301-620x.92b3.22913 Selvarajah, E., & Hooper, G. (2009). Restoration of the joint line in total knee arthroplasty. Journal of Arthroplasty, 24(7), 1099- 1102. doi: 10.1016/j.arth.2008.06.030 Sinnott, A. K., Brander, P., Siegert, R. J., Rothwell, A. G., & De Jong, G. (2009). Life impacts following reconstructive hand surgery for tetraplegia. Topics in Spinal Cord Injury Rehabilitation, 15(2), 90-97. doi: 10.1310/sci1502-90 Staiger, M. P., Kolbeinsson, I., Kirkland, N., Nguyen, T., Dias, G., & Woodfield, T. B. F. (2010). Synthesis of topologically- ordered open-cell porous magnesium. Materials Letters, Advance Online Publication. doi: 10.1016/j.matlet.2010.08.049 Talbot, S., Hooper, G., Stokes, A., & Zordan, R. (2010). Use of a new high-activity arthroplasty score to assess function of young patients with total hip or knee arthroplasty. Journal of Arthroplasty, 25(2), 268-273. doi: 10.1016/j.arth.2008.09.019 Whitehead, D. J., Hooper, G. J., & Bell, V. (2009). Clinical and radiological outcomes after revision to the low-contact-stress mobile-bearing total knee arthroplasty. ANZ Journal of Surgery, 79(5), 348-351. doi: 10.1111/j.1445-2197.2009.04887.x Woodfield, T. B. F., Guggenheim, M., von Rechenberg, B., Riesle, J., van Blitterswijk, C. A., & Wedler, V. (2009). Rapid prototyping of anatomically shaped, tissue-engineered implants for restoring congruent articulating surfaces in small joints. Cell Proliferation, 42(4), 485-497. doi: 10.1111/j.1365-2184.2009.00608.x Woodfield, T. B. F., Moroni, L., & Malda, J. (2009). Combinatorial approaches to controlling cell behaviour and tissue formation in 3D via rapid-prototyping and smart scaffold design. Combinatorial Chemistry & High Throughput Screening, 12(6), 562-579.

Journal - Research Other Sinnott, K. A., Cassidy, B., Nunnerley, J. L., Bourke, J., & Kunowski, T. (2010). Commentary on community participation following spinal cord injury in New Zealand. Topics in Spinal Cord Injury Rehabilitation, 15(4), 63-71. doi: 10.1310/ sci1504-063

232 RESEARCH REPORT 2009/2010 University of Otago, Christchurch Department of Paediatrics

Journal - Research Article Aït-Khaled, N., Pearce, N., Anderson, H. R., Ellwood, P., Montefort, S., Shah, J., ISAAC Phase Three Study Group, including Crane, J., & Pattemore, P. (2009). Global map of the prevalence of symptoms of rhinoconjunctivitis in children: The International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three. Allergy, 64(1), 123-148. doi: 10.1111/j.1398-9995.2008.01884.x Anderson, N. G., Fischer, J., Leighton, D., Hector-Taylor, J., & McEwing, R. L. (2010). Management in children of mild postnatal renal dilatation but without vesicoureteral reflux. Pediatric Nephrology, 25(3), 477-843. doi: 10.1007/s00467-009- 1348-x Asher, M. I., Stewart, A. W., Mallol, J., ..., ISAAC Phase One Study Group, including Crane, J., & Pattemore, P. (2010). Which population level environmental factors are associated with asthma, rhinoconjunctivitis and eczema? Review of the ecological analyses of ISAAC Phase One. Respiratory Research, 11, 8. Retrieved from http://respiratory-research.com/ content/11/1/8 Aurangzeb, B., Leach, S. T., Lemberg, D. A., & Day, A. S. (2010). Nutritional status of children with coeliac disease. Acta Paediatrica, 99(7), 1020-1025. doi: 10.1111/j.1651-2227.2010.01732.x Bagshaw, P. F., Allardyce, R. A., Bagshaw, S. N., Stokes, B. W., Shaw, C. S., Proffit, L. J., Nicholls, M. G., Begg, E. J., & Frampton, C. M. (2010). Patients “falling through the cracks”. The Canterbury Charity Hospital: Initial progress report. New Zealand Medical Journal, 123(1320). Retrieved from http://www.nzma.org.nz/journal/archive.php Begg, E. J., Vella-Brincat, J. W. A., Robertshawe, B., McMurtrie, M. J., Kirkpatrick, C. M. J., & Darlow, B. (2009). Eight years’ experience of an extended-interval dosing protocol for gentamicin in neonates. Journal of Antimicrobial Chemotherapy, 63, 1043-1049. doi: 10.1093/jac/dkp073 Chao, M. M., Todd, M. A., Kontny, U., Neas, K., Sullivan, M. J., Hunter, A. G., Picketts, D. J., & Kratz, C. P. (2010). T-cell acute lymphoblastic leukemia in association with Börjeson-Forssman-Lehmann Syndrome due to a mutation in PHF6. Pediatric Blood & Cancer, 55(4), 722-724. doi: 10.1002/pbc.22574 Clausell, J., Happel, N., Hale, T. K., Doenecke, D., & Beato, M. (2009). Histone H1 subtypes differentially modulate chromatin condensation without preventing ATP-dependent remodeling by SWI/SNF or NURF. PLoS ONE, 4(10), e0007243. doi: 10.1371/journal.pone.0007243 Collyns, O., Gillett, G., & Darlow, B. (2009). Overlap of premature birth and permissible abortion. Journal of Medical Ethics, 35(6), 343-347. doi: 10.1136/jme.2008.028928 Darlow, B. A., Horwood, L. J., Wynn-Williams, M. B., Mogridge, N., & Austin, N. C. (2009). Admissions of all gestations to a regional neonatal unit versus controls: 2-year outcome. Journal of Paediatrics and Child Health, 45(4), 187-193. doi: 10.1111/j.1440-1754.2008.01457.x Darlow, B. A., Mogridge, N., Horwood, L. J., Wynn-Williams, M. B., & Austin, N. C. (2009). Admission of all gestations to a regional neonatal unit versus controls: Neonatal morbidity. Journal of Paediatrics and Child Health, 45(4), 181-186. doi: 10.1111/j.1440-1754.2009.01486.x Day, A. S., & Gearry, R. B. (2010). Rifaximin and Crohn’s disease: A new solution to an old problem? Digestive Diseases and Sciences, 55, 877-879. doi: 10.1007/s10620-010-1140-6 Ellison-Loschmann, L., Pattemore, P. K., Asher, M. I., Clayton, T. O., Crane, J., Ellwood, P., MacKay, R. J., Mitchell, E. A., Moyes, C. D., Pearce, N., & Stewart, A. W. (2009). Ethnic differences in time trends in asthma prevalence in New Zealand: ISAAC Phases I and III. International Journal of Tuberculosis and Lung Disease, 13(6), 775-782. Ellwood, P., Asher, M. I., Stewart, A. W., ISAAC Phase III Study Group, including Crane, J., & Pattemore, P. (2010). The impact of the method of consent on response rates in the ISAAC time trends study. International Journal of Tuberculosis and Lung Disease, 14(8), 1059-1065. Ellwood, P., Williams, H., Aït-Khaled, N., Björkstén, B., Robertson, C., ISAAC Phase III Study Group, including Crane, J., & Pattemore, P. (2009). Translation of questions: The International Study of Asthma and Allergies in Childhood (ISAAC) experience. International Journal of Tuberculosis and Lung Disease, 13(9), 1174-1182. Harris, S. L., Smith, M. P., Laurie, A., & Darlow, B. A. (2010). Neonatal renal vein thrombosis and prothrombotic risk. Acta Paediatrica, 99(7), 1104-1107. doi: 10.1111/j.1651-2227.2010.01717.x Howell, A., Isaacs, D., Halliday, R., Australasian Study Group For Neonatal Infections, & including Darlow, B. (2009). Oral nystatin prophylaxis and neonatal fungal infections. Archives of Disease in Childhood: Fetal and Neonatal Edition, 94, F429-F433. doi: 10.1136/adc.2008.157123 Kaakoush, N. O., Holmes, J., Octavia, S., ..., Day, A. S., et al. (2010). Detection of Helicobacteraceae in intestinal biopsies of children with Crohn’s disease. Helicobacter, 15(6), 549-557. doi: 10.1111/j.1523-5378.2010.00792.x Kunac, D. L., Kennedy, J., Austin, N. C., & Reith, D. M. (2010). Risk factors for adverse drug events and medication errors in paediatric inpatients: Analysis by admission characteristics. Journal of Pharmacy Practice and Research, 40(4), 290-293. Kunac, D. L., Kennedy, J., Austin, N., & Reith, D. (2009). Incidence, preventability, and impact of adverse drug events (ADEs) and potential ADEs in hospitalized children in New Zealand: A prospective observational cohort study. Pediatric Drugs, 11(2), 153-160. doi: 10.2165/00148581-200911020-00005 Liberty, K. A., Pattemore, P., Reid, J., & Tarren-Sweeney, M. (2010). Beginning school with asthma independently predicts low achievement in a prospective cohort of children. Chest, 138(6), 1349-1355. doi: 10.1378/chest.10-0543

Division of HEALTH SCIENCES 233 Man, S. M., Kaakoush, N. O., Leach, S. T., ..., Day, A. S., et al. (2010). Host attachment, invasion, and stimulation of proinflammatory cytokines by Campylobacter concisus and other non-Campylobacter jejuni Campylobacter species. Journal of Infectious Diseases, 202(12), 1855-1865. doi: 10.1086/657316 Miller, L. J., Pearce, J., Barnett, R., Willis, J., Darlow, B. A., & Scott, R. S. (2009). Is population mixing associated with childhood type 1 diabetes in Canterbury, New Zealand? Social Science and Medicine, 68(4), 625-630. doi: 10.1016/j. socscimed.2008.11.027 Miller, L. J., Willis, J. A., Pearce, J., Barnett, R., Darlow, B. A., & Scott, R. S. (2010). Urban-rural variation in childhood type 1 diabetes incidence, in Canterbury, New Zealand 1980 to 2004. Health & Place, Advance Online Publication. doi: 10.1016/j. healthplace.2010.10.010 Mitchell, E. A., Stewart, A. W., Clayton, T., Asher, M. I., Ellwood, P., MacKay, R., Moyes, C. D., Pattemore, P. K., & Pearce, N. (2009). Cross-sectional survey of risk factors for asthma in 6-7-year-old children in New Zealand: International Study of Asthma and Allergy in Childhood Phase Three. Journal of Paediatrics and Child Health, 45(6), 375-383. doi: 10.1111/j.1440-1754.2009.01504.x Otley, A. R., Russell, R. K., & Day, A. S. (2010). Nutritional therapy for the treatment of pediatric Crohns disease. Expert Review of Clinical Immunology, 6(4), 667-676. doi: 10.1586/eci.10.37 Pham, M., Leach, S. T., Lemberg, D. A., & Day, A. S. (2010). Subclinical intestinal inflammation in siblings of children with Crohn’s disease. Digestive Diseases and Sciences, 55(12), 3502-3507. doi: 10.1007/s10620-010-1434-8 Quinn, G. E., Gilbert, C., Darlow, B. A., & Zin, A. (2010). Retinopathy of prematurity: An epidemic in the making. Chinese Medical Journal, 123(20), 2929-2937. doi: 10.3760/cma.j.issn.0366-6999.2010.20.033 Schultz, M., Gearry, R., Walmsley, R., Day, A. S., Fraser, A., Wyeth, J., Barclay, M., Clover, G., & Whiteside, C. (2010). New Zealand Society of Gastroenterology statement on the use of biological therapy in inflammatory bowel disease. New Zealand Medical Journal, 123(1314). Retrieved from http://www.nzma.org.nz/journal/archive.php Scott-Thomas, A. J., Syhre, M., Pattemore, P. K., Epton, M., Laing, R., Pearson, J., & Chambers, S. T. (2010). 2-Aminoacetophenone as a potential breath biomarker for Pseudomonas aeruginosa in the cystic fibrosis lung. BMC Pulmonary Medicine, 10, 56. Retrieved from http://www.biomedcentral.com/1471-2466/10/56 Silvers, K. M., Frampton, C. M., Wickens, K., Epton, M. J., Pattemore, P. K., Ingham, T., Fishwick, D., Crane, J., Town, G. I., & New Zealand Asthma and Allergy Cohort Study Group (2009). Breastfeeding protects against adverse respiratory outcomes at 15 months of age. Maternal and Child Nutrition, 5(3), 243-250. doi: 10.1111/j.1740-8709.2008.00169.x Sklavos, A. V., Walls, T., Webber, M. T., & Watson, A. B. (2010). Cutaneous leishmaniasis in a child treated with oral fluconazole. Australasian Journal of Dermatology, 51(3), 195-197. doi: 10.1111/j.1440-0960.2010.00642.x Slatter, T., Gifford-Garner, J., Wiles, A., Tan, X., Chen, Y-J., MacFarlane, M., Sullivan, M., Royds, J., & Hung, N. (2010). Pilocytic astrocytomas have telomere-associated promyelocytic leukemia bodies without alternatively lengthened telomeres. American Journal of Pathology, 177(6), 2694-2700. doi: 10.2353/ajpath.2010.100468 Stewart, L. C., Day, A. S., Pearson, J., Barclay, M. L., Gearry, R. B., Roberts, R. L., & Bentley, R. W. (2010). SLC11A1 polymorphisms in inflammatory bowel disease and Mycobacterium avium subspecies paratuberculosis status. World Journal of Gastroenterology, 16(45), 5727-5731. doi: 10.3748/wjg.v16.i45.5727 Tovaranonte, P. P., Beasley, S. W., Maoate, K., Blakelock, R., & Skinner, A. (2010). Trends in the use of minimally invasive surgery in children. New Zealand Medical Journal, 123(1313). Retrieved from http://www.nzma.org.nz/journal/archive. shtml Walls, T., Palasanthiran, P., Studdert, J., Moran, K., & Ziegler, J. B. (2010). Breastfeeding in mothers with HIV. Journal of Paediatrics and Child Health, 46(6), 349-352. doi: 10.1111/j.1440-1754.2010.01791.x Wickens, K., Beasley, R., Town, G. I., Epton, M., Pattemore, P., Ingham, T., Crane, J., & New Zealand Asthma and Allergy Cohort Study Group (2010). The effects of early and late paracetamol exposure on asthma and atopy: A birth cohort. Clinical & Experimental Allergy, Advance Online Publication. doi: 10.1111/j.1365-2222.2010.03610.x Wong, S., Lemberg, D. A., & Day, A. S. (2010). Exclusive enteral nutrition in the management of perianal Crohn’s disease in children. Journal of Digestive Diseases, 11(3), 185-188. doi: 10.1111/j.1751-2980.2010.00434.x Yeong, M. M-K., Palasanthiran, P., Ziegler, J. B., & Walls, T. (2010). Syndrome of inappropriate antidiuretic hormone associated with lopinavir therapy [Brief Report]. Pediatric Infectious Disease Journal, 29(7), 678-679. doi: 10.1097/ INF.0b013e3181d95b37 Yoshida, A., Maoate, K., Blakelock, R. T., Robertson, S., & Beasley, S. (2010). Long-term functional outcomes in children with Currarino syndrome. Pediatric Surgery International, 26, 677-681. doi: 10.1007/s00383-010-2615-4 Zhang, L., Budiman, V., Day, A. S., Mitchell, H., Lemberg, D. A., Riordan, S. M., et al. (2010). Isolation and detection of Campylobacter concisus from saliva of healthy individuals and patients with inflammatory bowel disease. Journal of Clinical Microbiology, 48(8), 2965-2967. doi: 10.1128/JCM.02391-09 Zhang, L., Man, S. M., Day, A. S., Leach, S. T., Lemberg, D. A., et al. (2009). Detection and isolation of Campylobacter species other than C. jejuni from children with Crohn’s disease. Journal of Clinical Microbiology, 47(2), 453-455. doi: 10.1128/ JCM.01949-08 Zin, A. A., Lopes Moreira, M. E., Bunce, C., Darlow, B. A., & Gilbert, C. E. (2010). Retinopathy of prematurity in 7 neonatal units in Rio de Janeiro: Screening criteria and workload implications. Pediatrics, 126(2), e410-e417. doi: 10.1542/ peds.2010-0090

234 RESEARCH REPORT 2009/2010 Journal - Research Other Chieng, J. H. C., Garrett, J., Ding, S. L., & Sullivan, M. (2009). Clinical presentation and endoscopic features of primary gastric Burkitt lymphoma in childhood, presenting as a protein-losing enteropathy: A case report. Journal of Medical Case Reports, 3, 72. doi: 10.4076/1752-1947-3-7256 Darlow, B. A., Gilbert, C., Quinn, G. E., Azad, R., Ells, A. L., Fielder, A., & Zin, A. (2009). Promise and potential pitfalls of anti- VEGF drugs in retinopathy of prematurity. British Journal of Ophthalmology, 93(7), 986. doi: 10.1136/bjo.2008.156208 Gearry, R. B., Day, A. S., Barclay, M. L., Leong, R. W. L., & Sparrow, M. P. (2010). Azathioprine and allopurinol: A two-edged interaction [Editorial]. Journal of Gastroenterology and Hepatology, 25(4), 653-655. doi: 10.1111/j.1440-1746.2010.06254.x Low, I., Ch’ng, S., Ng, D., Sullivan, M., Brasch, H., Davis, P., & Tan, S. T. (2009). HER2 polysomy in aggresive head and neck cutaneous squamous cell carcinoma [Correspondence]. Human Pathology, 40(6), 902-903. doi: 10.1016/j. humpath.2008.12.012 Sullivan, M. J. (2009). Hepatoblastoma, cisplatin, and ototoxicity: Good news on deaf ears [Editorial]. Cancer, 115(24), 5623- 5626. doi: 10.1002/cncr:24668 Walls, T. (2010). Evaluation and management of fever in children [Editorial]. New Zealand Medical Journal, 123(1309). Retrieved from http://www.nzma.org.nz/journal/archive.php Walls, T., & Wilson, E. (2010). Has the time come for universal varicella (chicken pox) vaccination in New Zealand? [Editorial]. New Zealand Medical Journal, 123(1326). Retrieved from http://www.nzma.org.nz/journal/123-1326/4449/ content.pdf

Journal - Professional & Other Non-Research Articles Darlow, B. A. (2009). Indomethacin and retinopathy of prematurity [Letter to the editor]. The Journal of Pediatrics, 155(5), 763. doi: 10.1016/j.jpeds.2009.05.038 Gupta, N., & Day, A. S. (2010). Blue rubber bleb naevus syndrome [Editorial comment]. Journal of Paediatrics and Child Health, 46(1-2), 67-68. doi: 10.1111/j.1440-1754.2009.01667.x Tarnow-Mordi, W. O., Darlow, B., & Doyle, L. (2010). Target ranges of oxygen saturation in extremely preterm infants [Letter to the editor]. New England Journal of Medicine, 363(13), 1285-1286.

University of Otago, Christchurch Department of Pathology

Chapter in Book - Research Benjes, S. M., & Morris, C. M. (2009). LINE-1 elements. In M. Schwab (Ed.), Encyclopedia of cancer (2nd ed.). (pp. 1683-1685). New York: Springer. Cox, A. G., Winterbourn, C. C., & Hampton, M. B. (2010). Measuring the redox state of cellular peroxiredoxins by immunoblotting. In E. Cadenas & L. Packer (Eds.), Methods in enzymology: Thiol redox transitions in cell signaling: Part B: Cellular localization and signaling (Vol. 474) (pp. 51-66). San Diego, CA: Academic Press. doi: 10.1016/S0076- 6879(10)74004-0 Morris, C. M. (2009). Alu elements. In M. Schwab (Ed.), Encyclopedia of cancer (2nd ed.). (pp. 132-133). New York: Springer. Morris, C. M. (2009). Blast crisis. In M. Schwab (Ed.), Encyclopedia of cancer (2nd ed.). (pp. 373-374). New York: Springer. Morris, C. M., & Benjes, S. M. (2009). BCR-ABL1. In M. Schwab (Ed.), Encyclopedia of cancer (2nd ed.). (pp. 318-323). New York: Springer. Nagy, P., & Winterbourn, C. C. (2010). Redox chemistry of biological thiols. In J. C. Fishbein (Ed.), Advances in molecular toxicology (Vol. 4) (pp. 223-266). Amsterdam, The Netherlands: Elsevier. Requejo, R., Chouchani, E. T., Hurd, T. R., Menger, K. E., Hampton, M. B., & Murphy, M. P. (2010). Measuring mitochondrial protein thiol redox state. In E. Cadenas & L. Packer (Eds.), Methods in enzymology: Thiol redox transitions in cell signaling: Part B: Cellular localization and signaling (Vol. 474) (pp. 123-147). San Diego, CA: Academic Press. doi: 10.1016/S0076- 6879(10)74004-0

Journal - Research Article Amodeo, M. R., Clulow, T., Lainchbury, J., Murdoch, D. R., Gallagher, K., Dyer, A., Metcalf, S. L., Pithie, A. D., & Chambers, S. T. (2009). Outpatient intravenous treatment for infective endocarditis: Safety, effectiveness and one-year outcomes. Journal of Infection, 59(6), 387-393. doi: 10.1016/j.jinf.2009.09.009 Amodeo, M. R., Murdoch, D. R., & Pithie, A. D. (2010). Legionnaires’ disease caused by Legionella longbeachae and Legionella pneumophila: Comparison of clinical features, host-related risk factors and outcomes. Clinical Microbiology and Infection, 16(9), 1405-1407. doi: 10.1111/j.1469-0691.2009.03125.x Ang, S-F., Moochhala, S. M., & Bhatia, M. (2010). Hydrogen sulfide promotes transient receptor potential vanilloid 1-mediated neurogenic inflammation in polymicrobial sepsis. Critical Care Medicine, 38(2), 619-628. doi: 10.1097/ CCM.0b013e3181c0df00 Atkinson, W., Slow, S., Elmslie, J., Lever, M., Chambers, S. T., & George, P. M. (2009). Dietary and supplementary betaine: Effects on betaine and homocysteine concentrations in males. Nutrition, Metabolism and Cardiovascular Diseases, 19(11), 767-776. doi: 10.1016/j.numecd.2009.01.004

Division of HEALTH SCIENCES 235 Bae, I-G., Federspiel, J. J., Miró, J. M., ..., Murdoch, D. R., et al, & International Collaboration on Endocarditis - Microbiology Investigators (2009). Heterogeneous vancomycin-intermediate susceptibility phenotype in bloodstream methicillin- resistant Staphylococcus aureus isolates from an international cohort of patients with infective endocarditis: Prevalence, genotype, and clinical significance. Journal of Infectious Diseases, 200(9), 1355-1366. doi: 10.1086/606027 Bentley, R. W., Cleynen, I., Gearry, R. B., Barclay, M. L., Rutgeerts, P., Merriman, T. R., Ferrante, M., Roberts, R. L., & Vermeire, S. (2010). Evidence that glioma-associated oncogene homolog 1 is not a universal risk gene for inflammatory bowel disease in Caucasians. Genes & Immunity, Advance Online Publication. doi: 10.1038/gene.2010.15 Bentley, R. W., Pearson, J., Gearry, R. B., Barclay, M. L., McKinney, C., Merriman, T. R., & Roberts, R. L. (2010). Association of higher DEFB4 genomic copy number with Crohn’s disease. American Journal of Gastroenterology, 105(2), 354-359. doi: 10.1038/ajg.2009.582 Bernal, A. B., Vickers, M. H., Hampton, M. B., Poynton, R. A., & Sloboda, D. M. (2010). Maternal undernutrition significantly impacts ovarian follicle number and increases ovarian oxidative stress in adult rat offspring. PLoS ONE, 5(12), e15558. doi: 10.1371/journal.pone.0015558 Bhatia, M. (2010). Hydrogen sulfide and substance P in inflammation. Antioxidants & Redox Signaling, 12(10), 1191-1202. doi: 10.1089/ars.2009.2927 Bozonet, S. M., Scott-Thomas, A. P., Nagy, P., & Vissers, M. C. M. (2010). Hypothiocyanous acid is a potent inhibitor of apoptosis and caspase 3 activation in endothelial cells. Free Radical Biology and Medicine, 49(6), 1054-1063. doi: 10.1016/j. freeradbiomed.2010.06.028 Brennan, S. O., & Chan, T. (2010). Hb Perpignan [b136(H14)GLY®Ser], a silent variant associated with normal hematology. Hemoglobin, 34(2), 157-160. doi: 10.3109/03630261003677221 Brennan, S. O., Chan, T., Ryken, S., & Ruskova, A. (2009). A second case of HB Fontainebleau [a21(B2)Ala®Pro] in an individual with microcytosis. Hemoglobin, 33(3), 258-261. doi: 10.1080/03630260903061135 Brennan, S. O., Davis, R. L., Conard, K., Savo, A., & Furuya, K. N. (2010). Novel fibrinogen mutation g314Thr ® Pro (fibrinogen Al duPont) associated with hepatic fibrinogen storage disease and hypofibrinogenaemia. Liver International, Advance Online Publication. doi: 10.1111/j.1478-3231.2010.02312.x Brennan, S. O., Davis, R. L., Lowen, R., & Ruskova, A. (2009). Deletion of five residues from the coiled coil of fibrinogen (Bb Asn167_Glu171del) associated with bleeding and hypodysfibrinogenemia. Haematologica, 94(4), 585-588. doi: 10.3324/ haematol.2008.001412 Brennan, S. O., Ryken, S., & Chan, T. (2010). Hb Koya Dora [a142, Term®Ser (TAA>TCA in a2)]: A rare mutation of the a2 gene stop codon associated with a-thalassemia. Hemoglobin, 34(4), 402-405. doi: 10.3109/03630269.2010.486344 Brown, K. K., Blaikie, F. H., Smith, R. A. J., Tyndall, J. D. A., Lue, H., Bernhagen, J., Winterbourn, C. C., & Hampton, M. B. (2009). Direct modification of the proinflammatory cytokine macrophage migration inhibitory factor by dietary isothiocyanates. Journal of Biological Chemistry, 284(47), 32425-32433. doi: 10.1074/jbc.M109.047092 Brown, K. K., Cox, A. G., & Hampton, M. B. (2010). Mitochondrial respiratory chain involvement in peroxiredoxin 3 oxidation by phenethyl isothiocyanate and auranofin. FEBS Letters, 584, 1257-1262. doi: 10.1016/j.febslet.2010.02.042 Chambers, S. T., Bhandari, S., Scott-Thomas, A., & Syhre, M. (2010). Novel diagnostics: Progress toward a breath test for invasive Aspergillus fumigatus. Medical Mycology, Advance Online Publication. doi: 10.3109/13693786.2010.508187 Chambers, S. T., Syhre, M., Murdoch, D. R., McCartin, F. J., & Epton, M. J. (2009). Detection of 2-Pentylfuran in the breath of patients with Aspergillus fumigatus. Medical Mycology, 47(5), 468-476. doi: 10.1080/13693780802475212 Chapman, A. L. P., Morrissey, B. M., Vasu, V. T., Juarez, M. M., Houghton, J. S., Li, C-S., et al. (2010). Myeloperoxidase- dependent oxidative metabolism of nitric oxide in the cystic fibrosis airway. Journal of Cystic Fibrosis, 9, 84-92. doi: 10.1016/j.jcf.2009.10.001 Chapman, A. L. P., Skaff, O., Senthilmohan, R., Kettle, A. J., & Davies, J. N. (2009). Hypobromous acid and bromamine production by neutrophils and modulation by superoxide. Biochemical Journal, 417(3), 773-781. doi: 10.1042/BJ20071563 Chin, P. K. L., Beckert, L. E. L., Gunningham, S., Edwards, A. L., & Robinson, B. A. (2009). Audit of anticoagulant thromboprophylaxis in hospitalized oncology patients. Internal Medicine Journal, 39(12), 819-825. doi: 10.1111/j.1445- 5994.2008.01828.x Christiaans, I., Kenter, S. B., Brink, H. C., ..., Kidd, A. M. J., & Hulsebos, T. J. M. (2010). Germline SMARCB1 mutation and somatic NF2 mutations in familial multiple meningiomas. Journal of Medical Genetics, Advance Online Publication. doi: 10.1136/jmg.2010.082420 Cox, A. G., Pearson, A. G., Pullar, J. M., Jönsson, T. J., Lowther, W. T., Winterbourn, C. C., & Hampton, M. B. (2009). Mitochondrial peroxiredoxin 3 is more resilient to hyperoxidation than cytoplasmic peroxiredoxins. Biochemical Journal, 421(1), 51-58. doi: 10.1042/BJ20090242 Cox, A. G., Peskin, A. V., Paton, L. N., Winterbourn, C. C., & Hampton, M. B. (2009). Redox potential and peroxide reactivity of human peroxiredoxin 3. Biochemistry, 48(27), 6495-6501. doi: 10.1021/bi900558g Cox, A. G., Winterbourn, C. C., & Hampton, M. B. (2010). Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling. Biochemical Journal, 425(2), 313-325. doi: 10.1042/BJ20091541 Cramp, G. J., Harte, D., Douglas, N. M., Graham, F., Schousboe, M., & Sykes, K. (2010). An outbreak of Pontiac fever due to Legionella longbeachae serogroup 2 found in potting mix in a horticultural nursery in New Zealand. Epidemiology and Infection, 138, 15-20. doi: 10.1017/S0950268809990835 Cuddihy, S. L., Baty, J. W., Brown, K. K., Winterbourn, C. C., & Hampton, M. B. (2009). Proteomic detection of oxidized and reduced thiol proteins in cultured cells. Methods in Molecular Biology, 519, 363-375. doi: 10.1007/978-1-59745-281-6_23

236 RESEARCH REPORT 2009/2010 Dachs, G. U., Hunt, M. A., Syddall, S., Singleton, D. C., & Patterson, A. V. (2009). Bystander or no bystander for gene directed enzyme prodrug therapy. Molecules, 14(11), 4517-4545. doi: 10.3390/molecules14114517 Dachs, G. U., Kano, M., Volkova, E., Morrin, H. R., Davey, V. C. L., Harris, G. C., Cheale, M., Frampton, C., Currie, M. J., Wells, J. E., & Robinson, B. A. (2010). A profile of prognostic and molecular factors in European and Mäori breast cancer patients. BMC Cancer, 10, 543. Retrieved from http://www.biomedcentral.com/1471-2407/10/543 Dalton, S. C., & Chambers, S. T. (2009). Cutaneous myiasis due to Dermatobia hominis (the human botfly) in a New Zealand traveller returned from South America. New Zealand Medical Journal, 122(1302). Retrieved from http://www.nzma.org.nz/ journal/122-1302/3778/ Das, A. B., Nagy, P., Abbott, H. F., Winterbourn, C. C., & Kettle, A. J. (2010). Reactions of superoxide with the myoglobin tyrosyl radical. Free Radical Biology and Medicine, 48, 1540-1547. doi: 10.1016/j.freeradbiomed.2010.02.039 Davis, R. L., Homer, V. M., George, P. M., & Brennan, S. O. (2009). A deep intronic mutation in FGB creates a consensus exonic splicing enhancer motif that results in afibrinogenemia caused by aberrant mRNA splicing, which can be corrected in vitro with antisense oligonucleotide treatment. Human Mutation, 30(2), 221-227. doi: 10.1002/humu.20839 Dempfle, C-E., George, P. M., Borggrefe, M., Neumaier, M., & Brennan, S. O. (2009). Demonstration of heterodimeric fibrinogen molecules partially conjugated with albumin in a novel dysfibrinogen: Fibrinogen Mannheim V. Thrombosis and Haemostasis, 102, 29-34. doi: 10.1160/TH08-09-0559 Dorin, R. I., Pai, H. K., Ho, J. T., Lewis, J. G., Torpy, D. J., Urban III, F. K., & Qualls, C. R. (2009). Validation of a simple method of estimating plasma free cortisol: Role of cortisol binding to albumin. Clinical Biochemistry, 42(1-2), 64-71. doi: 10.1016/j.clinbiochem.2008.09.115 Doudney, K., Harley, J. A., Pearson, J. F., Miller, A., Aitchison, A., Kennedy, M. A., Porter, R. J., Elmslie, J. L., & Joyce, P. R. (2009). Upstream genetic variant near INSIG2, influences response to carnitine supplementation in bipolar patients with valproate-induced weight gain. Acta Neuropsychiatrica, 21(3), 133-140. doi: 10.1111/j.1601-5215.2009.00379.x Duncan, A. R., Priest, P. C., Jennings, L. C., Brunton, C. R., & Baker, M. G. (2009). Screening for influenza infection in international airline travelers. American Journal of Public Health, 99(Suppl. 2), S360-S362. doi: 10.2105/AJPH.2008.158071 Ellison-Loschmann, L., Pattemore, P. K., Asher, M. I., Clayton, T. O., Crane, J., Ellwood, P., MacKay, R. J., Mitchell, E. A., Moyes, C. D., Pearce, N., & Stewart, A. W. (2009). Ethnic differences in time trends in asthma prevalence in New Zealand: ISAAC Phases I and III. International Journal of Tuberculosis and Lung Disease, 13(6), 775-782. Endre, Z. H., Walker, R. J., Pickering, J. W., Shaw, G. M., Frampton, C. M., Henderson, S. J., Hutchinson, R., Mehrtens, J. E., Robinson, J. M., Schollum, J. B. W., Westhuyzen, J., Celi, L. A., McGinley, R. J., Campbell, I. J., & George, P. M. (2010). Early intervention with erythropoietin does not affect the outcome of acute kidney injury (the EARLYARF trial). Kidney International, 77, 1020-1030. doi: 10.1038/ki.2010.25 Florkowski, C., Budgen, C., Kendall, D., Lunt, H., & Moore, M. P. (2009). Comparison of blood glucose meters in a New Zealand diabetes centre. Annals of Clinical Biochemistry, 46, 302-305. doi: 10.1258/acb.2009.008193

Florkowski, C., & Crooke, M. (2010). Standardisation of reporting haemoglobin A1c: Adoption of the New Zealand Society for the Study of Diabetes (NZSSD) position statement. New Zealand Medical Journal, 123(1310). Retrieved from http://www. nzma.org.nz/journal/archive.shtml Glubb, D. M., Joyce, P. R., & Kennedy, M. A. (2009). Expression and association analyses of promoter variants of the neurogenic gene HES6, a candidate gene for mood disorder susceptibility and antidepressant response. Neuroscience Letters, 460, 185-190. doi: 10.1016/j.neulet.2009.05.065 Glubb, D. M., McHugh, P. C., Deng, X., Joyce, P. R., & Kennedy, M. A. (2010). Association of a functional polymorphism in the adrenomedullin gene (ADM) with response to paroxetine. Pharmacogenomics Journal, 10, 126-133. doi: 10.1038/ tpj.2009.33 Guise, C. P., Abbattista, M. R., Singleton, R. S., Holford, S. D., Connolly, J., Dachs, G. U., et al. (2010). The bioreductive prodrug PR-104A is activated under aerobic conditions by human aldo-keto reductase 1C3. Cancer Research, 70(4), 1573-1584. doi: 10.1158/0008-5472.CAN-09-3237 Harley, J., Roberts, R., Joyce, P., Mulder, R., Luty, S., Frampton, C., & Kennedy, M. (2010). Orosomucoid influences the response to antidepressants in major depressive disorder. Journal of Psychopharmacology, 24(4), 531-535. doi: 10.1177/0269881109105101 Harris, S. L., Smith, M. P., Laurie, A., & Darlow, B. A. (2010). Neonatal renal vein thrombosis and prothrombotic risk. Acta Paediatrica, 99(7), 1104-1107. doi: 10.1111/j.1651-2227.2010.01717.x Harwood, D. T., Kettle, A. J., Brennan, S., & Winterbourn, C. C. (2009). Simultaneous determination of reduced glutathione, glutathione disulphide and glutathione sulphonamide in cells and physiological fluids by isotope dilution liquid chromatography-tandem mass spectrometry. Journal of Chromatography B, 877, 3393-3399. doi: 10.1016/j. jchromb.2009.04.018 Hegde, A., Tamizhselvi, R., Manikandan, J., Melendez, A. J., Moochhala, S. M., & Bhatia, M. (2010). Substance P in polymicrobial sepsis: Molecular fingerprint of lung injury in preprotachykinin-A-/- mice. Molecular Medicine, 16, 188-198. doi: 10.2119/molmed.2009.00166 Hernandez, E., Ganly, P., Charu, V., DiBenedetto, J., Tomita, D., Lillie, T., Taylor, K., & ARANESP 20030232 Study Group (2009). Randomized, double-blind, placebo-controlled trial of every-3-week darbepoetin alfa 300 micrograms for treatment of chemotherapy-induced anemia. Current Medical Research and Opinion, 25(9), 2109-2120. doi: 10.1185/03007990903084164

Division of HEALTH SCIENCES 237 Hien, V. T. T., Lam, N. T. T., Khan, N. C., Dung, N. T., Skeaff, C. M., Venn, B. J., Walmsley, T., George, P. M., McLean, J., Brown,

M. R., & Green, T. J. (2009). Folate and vitamin B12 status of women of reproductive age living in Hanoi City and Hai Duong Province of Vietnam. Public Health Nutrition, 12(7), 941-946. doi: 10.1017/s1368980008003479 Hock, B. D., Fernyhough, L. J., Gough, S. M., Steinkasserer, A., Cox, A. G., & McKenzie, J. L. (2009). Release and clinical significance of soluble CD83 in chronic lymphocytic leukemia. Leukemia Research, 33(8), 1089-1095. doi: 10.1016/j. leukres.2009.01.001 Hock, B. D., McKenzie, J. L., McArthur, L., Tansley, S., Taylor, K. G., & Fernyhough, L. J. (2010). CD38 as a prognostic marker in chronic lymphocytic leukaemia at a single New Zealand centre: Patient survival in comparison to age and sex matched population data. Internal Medicine Journal, 40(12), 842-849. doi: 10.1111/j.1445-5994.2009.02135.x Ho, J. T., Chapman, M. J., O’Connor, S., Lam, S., Edwards, J., Ludbrook, G., Lewis, J. G., & Torpy, D. J. (2010). Characteristics of plasma NOx levels in severe sepsis: High interindividual variability and correlation with illness severity, but lack of correlation with cortisol levels. Clinical Endocrinology, Advance Online Publication. doi: 10.1111/j.1365-2265.2010.03817.x Hollis-Moffatt, J. E., Merriman, M. E., Rodger, R. A., Rowley, K. A., Chapman, P. T., Dalbeth, N., Gow, P. J., Harrison, A. A., Highton, J., Jones, P. B. B., O’Donnell, J. L., Stamp, L. K., & Merriman, T. R. (2009). Evidence for association of an interleukin 23 receptor variant independent of the R381Q variant with rheumatoid arthritis. Annals of the Rheumatic Diseases, 68(8), 1340-1344. doi: 10.1136/ard.2008.090142 Holt, K. E., Baker, S., Dongol, S., Basnyat, B., Adhikari, N., ..., Murdoch, D. R., et al. (2010). High-throughput bacterial SNP typing identifies distinct clusters of Salmonella Typhi causing typhoid in Nepalese children. BMC Infectious Diseases, 10, 144. doi: 10.1186/1471-2334-10-144 Holt, K. E., Baker, S., Dongol, S., ..., Murdoch, D. R., Kelly, D. F., Pollard, A. J., & Dougan, G. (2010). High-throughput bacterial SNP typing identifies distinct clusters of Salmonella Typhi causing typhoid in Nepalese children. BMC Infectious Diseases, 10, 144. doi: 10.1186/1471-2334-10-144 Huang, Q. S., Bandaranayake, D., Lopez, L. D., ..., Jennings, L., ..., & Baker, M. (2009). Surveillance for the 2009 pandemic influenza A (H1N1) virus and seasonal influenza viruses: New Zealand, 2009. Morbidity and Mortality Weekly Report, 58(33), 918-921. Huggan, P. J., Wells, J. E., Browne, M., Richardson, A., Murdoch, D. R., & Chambers, S. T. (2010). Population-based epidemiology of Staphylococcus aureus bloodstream infection in Canterbury, New Zealand. Internal Medicine Journal, 40(2), 117-125. doi: 10.1111/j.1445-5994.2009.01910.x Hughes, L. M., Covian, R., Gribble, G. W., & Trumpower, B. L. (2010). Probing binding determinants in center P of the

cytochrome bc1 complex using novel hydroxy-naphthoquinones. Biochimica et Biophysica Acta, 1797(1), 38-43. doi: 10.1016/j.bbabio.2009.07.010 Hughes, L. M., Griffith, R., Carey, A., Butler, T., Donne, S. W., Beagley, K. W., & Aitken, R. J. (2009). The spermostatic and microbicidal actions of quinones and maleimides: Toward a dual-purpose contraceptive agent. Molecular Pharmacology, 76(1), 113-124. doi: 10.1124/mol.108.053645 Hunt, M. A., Currie, M. J., Robinson, B. A., & Dachs, G. U. (2010). Optimizing transfection of primary human umbilical vein endothelial cells using commercially available chemical transfection reagents. Journal of Biomolecular Techniques, 21, 66-72. Hutchinson, C., Hanger, C., Wilkinson, T., Sainsbury, R., & Pithie, A. (2009). Spontaneous spinal infections in older people. Internal Medicine Journal, 39(12), 845-848. doi: 10.1111/j.1445-5994.2009.02052.x Jennings, L. C., Skopnik, H., Burckhardt, I., Hribar, I., Del Piero, L., & Deichmann, K. A. (2009). Effect of rapid influenza testing on the clinical management of paediatric influenza. Influenza and other Respiratory Viruses, 3(3), 91-98. doi: 10.1111/j.1750-2659.2009.00079.x Joyce, P. R., Light, K. J., Rowe, S. L., Cloninger, C. R., & Kennedy, M. A. (2010). Self-mutilation and suicide attempts: Relationships to bipolar disorder, borderline personality disorder, temperament and character. Australian and New Zealand Journal of Psychiatry, 44(3), 250-257. doi: 10.3109/00048670903487159 Joyce, P. R., McHugh, P. C., Light, K. J., Rowe, S., Miller, A. L., & Kennedy, M. A. (2009). Relationships between angry-impulsive personality traits and genetic polymorphisms of the dopamine transporter. Biological Psychiatry, 66(8), 717-721. doi: 10.1016/j.biopsych.2009.03.005 Keenan, J. I., Salm, N., Hampton, M. B., & Wallace, A. J. (2010). Individual and combined effects of foods on Helicobacter pylori growth. Phytotherapy Research, 24(8), 1229-1233. doi: 10.1002/ptr.3167 Kelly, D. F., Thorson, S., Maskey, M., ..., Werno, A. M., ..., Murdoch, D. R., & Pollard, A. J. (2010). The burden of vaccine- preventable invasive bacterial infections and pneumonia in children admitted to hospital in urban Nepal. International Journal of Infectious Diseases, Advance Online Publication. doi: 10.1016/j.ijid.2010.05.021 Khashram, M., Huggan, P., Ikram, R., Chambers, S., Roake, J. A., & Lewis, D. R. (2009). Effect of TNP on the microbiology of venous leg ulcers: A pilot study. Journal of Wound Care, 18(4), 164-167. King, R. I., & Florkowski, C. M. (2010). How paraproteins can affect laboratory assays: Spurious results and biological effects. Pathology, 42(5), 397-401. doi: 10.3109/00313025.2010.493868 King, R. I., Scott, R. S., Florkowski, C. M., Laurie, A. D., Reid, N., & George, P. M. (2010). Homozygous familial hypercholesterolaemia and treatment by LDL apheresis. New Zealand Medical Journal, 123(1319). Retrieved from http:// www.nzma.org.nz/journal/123-1319/4230/ Koelsch, M., Mallak, R., Graham, G. G., Kajer, T., Milligan, M. K., Nguyen, L. Q., Newsham, D. W., Keh, J. S., Kettle, A. J., et al. (2010). Acetaminophen (paracetamol) inhibits myeloperoxidase-catalyzed oxidant production and biological damage at therapeutically achievable concentrations. Biochemical Pharmacology, 79, 1156-1164. doi: 10.1016/j.bcp.2009.11.024

238 RESEARCH REPORT 2009/2010 Koh, Y-H., Tamizhselvi, R., & Bhatia, M. (2010). Extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase, through nuclear factor-kB and activator protein-1, contribute to caerulein-induced expression of substance P and neurokinin-1 receptors in pancreatic acinar cells. Journal of Pharmacology and Experimental Therapeutics, 332(3), 940-948. doi: 10.1124/jpet.109.160416 Kuiper, C., Molenaar, I. G. M., Dachs, G. U., Currie, M. J., Sykes, P. H., & Vissers, M. C. M. (2010). Low ascorbate levels are associated with increased hypoxia-inducible factor-1 activity and an aggressive tumor phenotype in endometrial cancer. Cancer Research, 70(14), 5749-5758. doi: 10.1158/0008-5472.CAN-10-0263 Kumar, V., Kitaeff, N., Hampton, M. B., Cannell, M. B., & Winterbourn, C. C. (2009). Reversible oxidation of mitochondrial peroxiredoxin 3 in mouse heart subjected to ischemia and reperfusion. FEBS Letters, 583(6), 997-1000. doi: 10.1016/j. febslet.2009.02.018 Laurie, A. D., & George, P. M. (2009). Evaluation of high-resolution melting analysis for screening the LDL receptor gene. Clinical Biochemistry, 42, 528-535. doi: 10.1016/j.clinbiochem.2008.11.015 Laurie, A. D., Hill, A. M., Harraway, J. R., Fellowes, A. P., Phillipson, G. T., Benny, P. S., Smith, M. P., & George, P. M. (2010). Preimplantation genetic diagnosis for hemophilia A using indirect linkage analysis and direct genotyping approaches. Journal of Thrombosis and Haemostasis, 8(4), 783-789. doi: 10.1111/j.1538-7836.2010.03768.x Lever, M., Atkinson, W., Slow, S., Chambers, S. T., & George, P. M. (2009). Plasma and urine betaine and dimethylglycine variation in healthy young male subjects. Clinical Biochemistry, 42(7-8), 706-712. doi: 10.1016/j.clinbiochem.2009.02.001 Lever, M., George, P. M., Slow, S., Elmslie, J. L., Scott, R. S., Richards, A. M., Fink, J. N., & Chambers, S. T. (2009). Fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine. Cardiovascular Drugs and Therapy, 23(5), 395-401. doi: 10.1007/s10557-009-6188-1 Lever, M., George, P. M., Slow, S., Elmslie, J. L., Shand, B. I., Scott, R. S., & Chambers, S. T. (2010). Fibrates plus betaine: A winning combination? [Viewpoint]. New Zealand Medical Journal, 123(1324). Retrieved from http://www.nzma.org.nz/ journal/123-1324/4389/content.pdf Lever, M., & Slow, S. (2010). The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism. Clinical Biochemistry, 43, 732-744. doi: 10.1016/j.clinbiochem.2010.03.009 Lewis, J. G., Borowski, K. K., Shand, B. I., George, P. M., & Scott, R. S. (2010). Plasma sex hormone-binding globulin, corticosteroid-binding globulin, cortisol, and free cortisol levels in outpatients attending a lipid disorders clinic: A cross- sectional study of 1137 subjects. Hormone and Metabolic Research, 42(4), 274-279. doi: 10.1055/s-0029-1243260 Lewis, J. G., & Rehm, B. H. A. (2009). ZZ polyester beads: An efficient and simple method for purifying IgG from mouse hybridoma supernatants. Journal of Immunological Methods, 346, 71-74. doi: 10.1016/j.jim.2009.04.011 Lewis, J. G., Shand, B. I., Frampton, C. M., Elder, P. A., & Scott, R. S. (2009). Plasma levels of sex hormone-binding globulin, corticosteroid-binding globulin and cortisol in overweight subjects who develop impaired fasting glucose: A 3-year prospective study. Hormone and Metabolic Research, 41(3), 255-259. doi: 10.1055/s-0028-1087190 Lunt, H., Florkowski, C., Bignall, M., & Budgen, C. (2010). Capillary glucose meter accuracy and sources of error in the ambulatory setting. New Zealand Medical Journal, 123(1310). Retrieved from http://www.nzma.org.nz/ journal/123-1310/4018/ Mackenzie, K. A., Wells, J. E., Lynn, K. L., Simcock, J. W., Robinson, B. A., Roake, J. A., & Currie, M. J. (2010). First and subsequent nonmelanoma skin cancers: Incidence and predictors in a population of New Zealand renal transplant recipients. Nephrology Dialysis Transplantation, 25, 300-306. doi: 10.1093/ndt/gfp482 Marr, H., McDonald, E-J., Merriman, E., Smith, M., Mangos, H., Stoddart, C., & Ganly, P. (2009). Successful treatment of transplant-associated microangiopathy with rituximab. New Zealand Medical Journal, 122(1292). Retrieved from http:// www.nzma.org.nz/journal/archive.shtml Marshall, C. J., Nallaratnam, M., Mocatta, T., Smyth, D., Richards, M., Elliott, J. M., Blake, J., Winterbourn, C. C., Kettle, A. J., & McClean, D. R. (2010). Factors influencing local and systemic levels of plasma myeloperoxidase in ST-segment elevation acute myocardial infarction. American Journal of Cardiology, 106(3), 316-322. doi: 10.1016/j.amjcard.2010.03.028 McDonald, E. J., & Butler, A. (2010). Immune thrombocytopaena in adults: A single-centre retrospective review of patients presenting over 7 years. New Zealand Medical Journal, 123(1312). Retrieved from http://www.nzma.org.nz/ journal/123-1312/4051/content.pdf McEntyre, C. J., Slow, S., & Lever, M. (2009). Measurement of plasma free choline by high performance liquid chromatography with fluorescence detection following derivatization with 1-naphthyl isocyanate. Analytica Chimica Acta, 644, 90-94. doi: 10.1016/j.aca.2009.04.014 McHugh, P. C., Joyce, P. R., Deng, X., & Kennedy, M. A. (2010). A polymorphism of the GTP-cyclohydrolase I feedback regulator gene alters transcriptional activity and may affect response to SSRI antidepressants. Pharmacogenomics Journal, Advance Online Publication. doi: 10.1038/tpj.2010.23 McHugh, P. C., Joyce, P. R., & Kennedy, M. A. (2009). Polymorphisms of sepiapterin reductase gene alter promoter activity and may influence risk of bipolar disorder. Pharmacogenetics and Genomics, 19(5), 330-337. doi: 10.1097/ FPC.0b013e328328f82c McHugh, P. C., Rogers, G. R., Glubb, D. M., Joyce, P. R., & Kennedy, M. A. (2010). Proteomic analysis of rat hippocampus exposed to the antidepressant paroxetine. Journal of Psychopharmacology, 24(8), 1243-1251. doi: 10.1177/0269881109102786 Miller, A., Rudland, J., Hurrell, M., & Ali, A. (2009). Rad-Path: Integrated anatomical pathology and radiology undergraduate tutorials. Pathology, 41(5), 460-466. doi: 10.1080/00313020903049286

Division of HEALTH SCIENCES 239 Mitchell, E. A., Stewart, A. W., Clayton, T., Asher, M. I., Ellwood, P., MacKay, R., Moyes, C. D., Pattemore, P. K., & Pearce, N. (2009). Cross-sectional survey of risk factors for asthma in 6-7-year-old children in New Zealand: International Study of Asthma and Allergy in Childhood Phase Three. Journal of Paediatrics and Child Health, 45(6), 375-383. doi: 10.1111/j.1440-1754.2009.01504.x

Molyneux, S. L., Florkowski, C. M., Richards, A. M., Lever, M., Young, J. M., & George, P. M. (2009). Coenzyme Q10; an adjunctive therapy for congestive heart failure? New Zealand Medical Journal, 122(1305). Retrieved from http://www. nzma.org.nz/journal/122-1305/3855/ Muir, L. A., George, P. M., Laurie, A. D., Reid, N., & Whitehead, L. (2010). Preventing cardiovascular disease: A review of the effectiveness of identifying the people with familial hypercholesterolaemia in New Zealand. New Zealand Medical Journal, 123(1326). Retrieved from http://www.nzma.org.nz/journal/123-1326/4439/ Murdoch, D. R., Corey, G. R., Hoen, B., ..., Chambers, S. T., et al, & the International Collaboration on Endocarditis Prospective Cohort Study (ICE-PCS) Investigators (2009). Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: The International Collaboration on Endocarditis-Prospective Cohort Study. Archives of Internal Medicine, 169(5), 463-473. Murdoch, D. R., & Jennings, L. C. (2009). Association of respiratory virus activity and environmental factors with the incidence of invasive pneumococcal disease. Journal of Infection, 58(1), 37-46. doi: 10.1016/j.jinf.2008.10.011 Murdoch, D. R., Jennings, L. C., Bhat, N., & Anderson, T. P. (2010). Emerging advances in rapid diagnostics of respiratory infections. Infectious Disease Clinics of North America, 24(3), 791-807. doi: 10.1016/j.idc.2010.04.006 Nagy, P., Jameson, G. N. L., & Winterbourn, C. C. (2009). Kinetics and mechanisms of the reaction of hypothiocyanous acid with 5-thio-2-nitrobenzoic acid and reduced glutathione. Chemical Research in Toxicology, 22(11), 1833-1840. doi: 10.1021/tx900249d Nagy, P., Kettle, A. J., & Winterbourn, C. C. (2009). Superoxide-mediated formation of tyrosine hydroperoxides and methionine sulfoxide in peptides through radical addition and intramolecular oxygen transfer. Journal of Biological Chemistry, 284(22), 14723-14733. doi: 10.1074/jbc.M809396200 Nagy, P., Kettle, A. J., & Winterbourn, C. C. (2010). Neutrophil-mediated oxidation of enkephalins via myeloperoxidase-dependent addition of superoxide. Free Radical Biology and Medicine, 49, 792-799. doi: 10.1016/j. freeradbiomed.2010.05.033 Nagy, P., & Winterbourn, C. C. (2010). Rapid reaction of hydrogen sulfide with the neutrophil oxidant hypochlorous acid to generate polysulfides. Chemical Research in Toxicology, Advance Online Publication. doi: 10.1021/tx100266a O’Reilly, J. N., Cogger, V. C., Fraser, R., & Le Couteur, D. G. (2010). The effect of feeding and fasting on fenestrations in the liver sinusoidal endothelial cell. Pathology, 42(3), 255-258. doi: 10.3109/00313021003636469 Palmer, B. R., Devereaux, C. L., Dhamrait, S. S., Mocatta, T. J., Pilbrow, A. P., Frampton, C. M., Skelton, L., Yandle, T. G., Winterbourn, C. C., Richards, A. M., Montgomery, H. E., & Cameron, V. A. (2009). The common G-866A polymorphism of the UCP2 gene and survival in diabetic patients following myocardial infarction. Cardiovascular Diabetology, 8. doi: 10.1186/1475-2840-8-31 Parker, H., Chitcholtan, K., Hampton, M. B., & Keenan, J. I. (2010). Uptake of Helicobacter pylori outer membrane vesicles by gastric epithelial cells. Infection and Immunity, Advance Online Publication. doi: 10.1128/IAI.00299-10 Paton, L. N., Mocatta, T. J., Richards, A. M., & Winterbourn, C. C. (2010). Increased thrombin-induced polymerization of fibrinogen associated with high protein carbonyl levels in plasma from patients post myocardial infarction. Free Radical Biology & Medicine, 48(2), 223-229. doi: 10.1016/j.freeradbiomed.2009.10.044 Peskin, A. V., Cox, A. G., Nagy, P., Morgan, P. E., Hampton, M. B., Davies, M. J., & Winterbourn, C. C. (2010). Removal of amino acid, peptide and protein hydroperoxides by reaction with peroxiredoxins 2 and 3. Biochemical Journal, 432, 313- 321. doi: 10.1042/BJ20101156 Peskin, A. V., Turner, R., Maghzal, G. J., Winterbourn, C. C., & Kettle, A. J. (2009). Oxidation of methionine to dehydromethionine by reactive halogen species generated by neutrophils. Biochemistry, 48(42), 10175-10182. doi: 10.1021/ bi901266w Petermann, I., Huebner, C., Browning, B. L., Gearry, R. B., Barclay, M. L., Kennedy, M., Roberts, R., Shelling, A. N., Philpott, M., Han, D. Y., & Ferguson, L. R. (2009). Interactions among genes influencing bacterial recognition increase IBD risk in a population-based New Zealand cohort. Human Immunology, 70, 440-446. doi: 10.1016/j.humimm.2009.03.002 Pradhan, M. A., Ng, Y., Strickland, A., George, P. M., Raizis, A., Warrington, J., & Vincent, A. L. (2010). Role of genetic testing in retinoblastoma management at a tertiary referral centre. Clinical and Experimental Ophthalmology, 38, 231-236. doi: 10.1111/j.1442-9071.2010.02239.x Raizis, A. M., Saleem, M., MacKay, R., & George, P. M. (2009). Spectrum of MECP2 mutations in New Zealand Rett syndrome patients. New Zealand Medical Journal, 122(1296). Retrieved from http://www.nzma.org.nz/journal/122-1296/3634 Ramnath, R. D., Sun, J., & Bhatia, M. (2010). PKC d mediates pro-inflammatory responses in a mouse model of caerulein- induced acute pancreatitis. Journal of Molecular Medicine, 88, 1055-1063. doi: 10.1007/s00109-010-0647-9 Robak, T., Dmoszynska, A., Solal-Céligny, P., Warzocha, K., Loscertales, J., ..., Ganly, P. S., et al. (2010). Rituximab plus fludarabine and cyclophosphamide prolongs progression-free survival compared with fludarabine and cyclophosphamide alone in previously treated chronic lymphocytic leukemia. Journal of Clinical Oncology, 28(10), 1756-1765. doi: 10.1200/ JCO.2009.26.4556 Saleem, M., Lewis, J. G., Florkowski, C. M., Mulligan, G. P., George, P. M., & Hale, P. (2009). A patient with pseudo-Addison’s disease and falsely elevated thyroxine due to interference in serum cortisol and free thyroxine immunoassays by two different mechanisms. Annals of Clinical Biochemistry, 46, 172-175. doi: 10.1258/acb.2008.008224

240 RESEARCH REPORT 2009/2010 Scott-Thomas, A. J., Syhre, M., Pattemore, P. K., Epton, M., Laing, R., Pearson, J., & Chambers, S. T. (2010). 2-Aminoacetophenone as a potential breath biomarker for Pseudomonas aeruginosa in the cystic fibrosis lung. BMC Pulmonary Medicine, 10, 56. Retrieved from http://www.biomedcentral.com/1471-2466/10/56 Shand, B. I., Scott, R. S., Lewis, J. G., Elder, P. A., & Frampton, C. M. (2009). Comparison of indices of insulin resistance with metabolic syndrome classifications to predict the development of impaired fasting glucose in overweight and obese subjects: A 3-year prospective study. International Journal of Obesity, 33(11), 1274-1279. doi: 10.1038/ijo.2009.169 Sheen, C. R., Dear, A., & Brennan, S. O. (2010). Expression of four mutant fibrinogen gC domains in Pichia pastoris confirms them as causes of hypofibrinogenaemia. Protein Expression and Purification, 73, 184-188. doi: 10.1016/j.pep.2010.05.008 Shrivastava, P., & Bhatia, M. (2010). Essential role of monocytes and macrophages in the progression of acute pancreatitis. World Journal of Gastroenterology, 16(32), 3995-4002. doi: 10.3748/wjg.v16.i32.3995 Sio, S. W. S., Ang, S. F., Lu, J., Moochhala, S., & Bhatia, M. (2010). Substance P upregulates cyclooxygenase-2 and prostaglandin E metabolite by activating ERK1/2 and NF-kB in a mouse model of burn-induced remote acute lung injury. Journal of Immunology, 185(10), 6265-6276. doi: 10.4049/jimmunol.1001739 Sio, S. W. S., Moochhala, S., Lu, J., & Bhatia, M. (2010). Early protection from burn-induced acute lung injury by deletion of preprotachykinin-A gene. American Journal of Respiratory and Critical Care Medicine, 181(1), 36-46. doi: 10.1164/ rccm.200907-1073OC Slow, S., Lever, M., Chambers, S. T., & George, P. M. (2009). Plasma dependent and independent accumulation of betaine in male and female rat tissues. Physiological Research, 58(3), 403-410. Smart, O. C., Sykes, P., McNab, H., & Jennings, L. (2010). Testing for high risk human papilloma virus in the initial follow-up of women treated for high-grade squamous intraepithelial lesions. Australian and New Zealand Journal of Obstetrics and Gynaecology, 50(2), 164-167. doi: 10.1111/j.1479-828X.2009.01132.x Sowmya, S., Swathi, Y., Yeo, A. L., Shoon, M. L., Moore, P. K., & Bhatia, M. (2010). Hydrogen sulfide: Regulatory role on blood pressure in hyperhomocysteinemia. Vascular Pharmacology, 53, 138-143. doi: 10.1016/j.vph.2010.05.004 Stacey, M. M., Peskin, A. V., Vissers, M. C., & Winterbourn, C. C. (2009). Chloramines and hypochlorous acid oxidize erythrocyte peroxiredoxin 2. Free Radical Biology & Medicine, 47(10), 1468-1476. doi: 10.1016/j. freeradbiomed.2009.08.022 Stamp, L. K., Chapman, P. T., O’Donnell, J. L., Zhang, M., James, J., Frampton, C., Barclay, M. L., Kennedy, M. A., & Roberts, R. L. (2010). Polymorphisms within the folate pathway predict folate concentrations but are not associated with disease activity in rheumatoid arthritis patients on methotrexate. Pharmacogenetics and Genomics, 20(6), 367-376. doi: Stamp, L. K., O’Donnell, J. L., Chapman, P. T., Zhang, M., Frampton, C., James, J., & Barclay, M. L. (2009). Determinants of red blood cell methotrexate polyglutamate concentrations in rheumatoid arthritis patients receiving long-term methotrexate treatment. Arthritis & Rheumatism, 60(8), 2248-2256. doi: 10.1002/art.24653 Stamp, L. K., O’Donnell, J. L., Chapman, P. T., Zhang, M., James, J., Frampton, C., & Barclay, M. L. (2010). Methotrexate polyglutamate concentrations are not associated with disease control in rheumatoid arthritis patients receiving long-term methotrexate therapy. Arthritis and Rheumatism, 62(2), 359-368. doi: 10.1002/art.27201 Stamp, L. K., O’Donnell, J. L., Zhang, M., James, J., Frampton, C., Barclay, M. L., & Chapman, P. T. (2010). Using allopurinol above the dose based on creatinine clearance is effective and safe in chronic gout, including in those with renal impairment. Arthritis & Rheumatism, Advance Online Publication. doi: 10.1002/art.30119 Stewart, L. C., Day, A. S., Pearson, J., Barclay, M. L., Gearry, R. B., Roberts, R. L., & Bentley, R. W. (2010). SLC11A1 polymorphisms in inflammatory bowel disease and Mycobacterium avium subspecies paratuberculosis status. World Journal of Gastroenterology, 16(45), 5727-5731. doi: 10.3748/wjg.v16.i45.5727 Surgenor, L. J., Spearing, R. L., Horn, J., Beautrais, A. L., Mulder, R. T., & Chen, P. (2009). Burnout in hospital-based medical consultants in the New Zealand public health system. New Zealand Medical Journal, 122(1300). Retrieved from http:// www.nzma.org.nz/journal/122-1300/3737/ Syhre, M., Manning, L., Phuanukoonnon, S., Harino, P., & Chambers, S. T. (2009). The scent of Mycobacterium tuberculosis: Part II breath. Tuberculosis, 89, 263-266. doi: 10.1016/j.tube.2009.04.003 Tamizhselvi, R., Koh, Y-H., Sun, J., Zhang, H., & Bhatia, M. (2010). Hydrogen sulfide-induces ICAM-1 expression and neutrophil adhesion to caerulein-treated pancreatic acinar cells through NF-kB and Src-family kinases pathway. Experimental Cell Research, 316, 1625-1636. doi: 10.1016/j.yexcr.2010.02.044 Than, M. P., Helm, J., Calder, K., Ardagh, M. W., Smith, M., Flaws, D. F., & Beckert, L. (2009). Comparison of high specificity with standard versions of a quantative latex D-dimer test in the assessment of community pulmonary embolism HaemosIL D-dimer HS and Pulmonary Embolism. Thrombosis Research, 124, 230-235. doi: 10.1016/j. thromres.2008.10.018 The International HIV Controllers Study, & including Chambers, S. T. (2010). The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. Science, 330(6010), 1551-1557. doi: 10.1126/science.1195271 Thomson, E., Brennan, S., Senthilmohan, R., Gangell, C. L., Chapman, A. L., Sly, P., & Kettle, A. J. (2010). Identifying peroxidases and their oxidants in the early pathology of cystic fibrosis. Free Radical Biology and Medicine, 49(9), 1354- 1360. doi: 10.1016/j.freeradbiomed.2010.07.010 Tupper, J., Stratford, M. R., Hill, S., Tozer, G. M., & Dachs, G. U. (2010). In vivo characterization of horseradish peroxidase with indole-3-acetic acid and 5-bromoindole-3-acetic acid for gene therapy of cancer. Cancer Gene Therapy, 17(6), 420-428. doi: 10.1038/cgt.2009.86 Uttamchandani, M., Moochhala, S. M., Bhatia, M., & Hegde, A. (2010). Plasma cytokine profiles in Preprotachykinin-A knockout mice subjected to polymicrobial sepsis. Molecular Medicine, 16(1-2), 45-52. doi: 10.2119/molmed.2009.00112

Division of HEALTH SCIENCES 241 van Dalen, C. J., Aldridge, R. E., Chan, T., Senthilmohan, R., Hancox, R. J., Cowan, J. O., Taylor, D. R., Town, G. I., & Kettle, A. J. (2009). Bromotyrosines in sputum proteins and treatment effects of terbutaline and budesonide in asthma. Annals of Allergy Asthma & Immunology, 103(4), 348-353. Vasudevamurthy, M. K., Lever, M., George, P. M., & Morison, K. R. (2009). Betaine structure and the presence of hydroxyl groups alters the effects on DNA melting temperatures. Biopolymers, 91(1), 85-94. doi: 10.1002/bip.21085 Vissers, M. C. M., Bozonet, S. M., Pearson, J. F., & Braithwaite, L. J. (2010). Dietary ascorbate intake affects steady state tissue concentrations in vitamin C-deficient mice: Tissue deficiency after suboptimal intake and superior bioavailability from a food source (kiwifruit). American Journal of Clinical Nutrition, Advance Online Publication. doi: Volkova, E., Willis, J. A., Wells, J. E., Robinson, B. A., Dachs, G. U., & Currie, M. J. (2010). Association of angiopoietin-2, C-reactive protein and markers of obesity and insulin resistance with survival outcome in colorectal cancer. British Journal of Cancer, Advance Online Publication. doi: 10.1038/sj.bjc.6606005 White, D. H. N., Chapman, P. T., O’Donnell, J. L., James, J., Frampton, C., & Stamp, L. K. (2010). Lack of association between elevated mean red cell volume and haematological toxicity in patients receiving long-term methotrexate for rheumatoid arthritis. Internal Medicine Journal, 40(8), 561-565. doi: 10.1111/j.1445-5994.2009.02059.x Williams, D., Begg, A., Burgess, K., Hider, M., Jennings, L., ..., Pithie, A., Schroeder, P., & Werno, A. (2010). Influenza H1N1 2009 in Canterbury: A case study in pandemic response co-ordination. Journal of Primary Health Care, 2(4), 323-329. Williams, E. J., Thorson, S., Maskey, M., Mahat, S., Hamaluba, M., Dongol, S., Werno, A. M., Yadav, B. K., Shah, A. S., Kelly, D. F., Adhikari, N., Pollard, A. J., & Murdoch, D. R. (2009). Hospital-based surveillance of invasive pneumococcal disease among young children in urban Nepal. Clinical Infectious Diseases, 48(Suppl. 2), S114-S122. doi: 10.1086/596488 Wong, J. S. J., Anderson, T. P., Chambers, S. T., On, S. L. W., & Murdoch, D. R. (2009). Campylobacter fetus-associated epidural abscess and bacteremia. Journal of Clinical Microbiology, 47(3), 857-858. doi: 10.1128/JCM.00725-08 Wong, J. S. J., Schousboe, M. I., Metcalf, S. S. L., Endre, Z. H., Hegarty, J. M., Maze, M. J., Keith, E. R., Seaward, L. M., & Podmore, R. G. (2010). Ochroconis gallopava peritonitis in a cardiac transplant patient on continuous ambulatory peritoneal dialysis [Case report]. Transplant Infectious Disease, 12(5), 455-458. doi: 10.1111/j.1399-3062.2010.00523.x Wong, J. S. J., Seaward, L. M., Ho, C. P., Anderson, T. P., Lau, E. O. C., Amodeo, M. R., Metcalf, S. C. L., Pithie, A. D., & Murdoch, D. R. (2010). Corynebacterium accolens associated pelvic osteomyelitis. Journal of Clinical Microbiology, 48(2), 654-655. doi: 10.1128/JCM.00818-09 Ximenes, V. F., Maghzal, G. J., Turner, R., Kato, Y., Winterbourn, C. C., & Kettle, A. J. (2010). Serotonin as a physiological substrate for myeloperoxidase and its superoxide-dependent oxidation to cytotoxic tryptamine-4,5-dione. Biochemical Journal, 425(1), 285-293. doi: 10.1042/BJ20090776 Zhang, J., Sio, S. W. S., Moochhala, S., & Bhatia, M. (2010). Role of hydrogen sulfide in severe burn injury-induced inflammation in mice. Molecular Medicine, 16(9-10), 417-424. doi: 10.2119/molmed.2010.00027

Journal - Research Other Badami, K. G., Vanhecke, C., & Bingham, J. (2009). Maternal IgM anti-D, borderline foetal Doppler middle cerebral artery velocities and absent neonatal haemolysis [Case report]. Transfusion Medicine, 19(3), 146-147. doi: 10.1111/j.1365- 3148.2009.00924.x Brennan, S. O., & Davis, R. L. (2010). Substitution (g335Trp®Arg) in fibrinogen Fremantle causes diminished g chain expression and increased sialic acid content [Letter to the Editor]. Thrombosis and Haemostasis, Advance Online Publication. doi: 10.1160/TH10-04-0252 Brennan, S. O., Davis, R. L., & Chitlur, M. (2010). New fibrinogen substitution (gSer313Arg) causes diminished g chain expression and hypodysfibrinogenaemia [Letter to the editor]. Thrombosis and Haemostasis, 103(2), 478-479. doi: 10.1160/ TH09-07-0459 Brennan, S. O., Davis, R. L., Lowen, R., & Baker, B. (2010). Benign substitution (Aa289 Arg®Gln) in the aC region of human fibrinogen [Letter to the editor]. Blood Cells, Molecules, and Diseases, Advance Online Publication. doi: 10.1016/j. bcmd.2010.08.009 Brennan, S. O., Oliver, J., & Davis, R. L. (2010). Adjacent substitutions (g352Gly®Cys and 353Thr®Pro) in fibrinogen Ilam cause diminished g chain expression [Letter to editor]. Thrombosis and Haemostasis, Advance Online Publication. doi: 10.1160/TH10-09-0619 Bryant, D. L., Miles, C. J., & Gearry, R. B. (2010). Nodular regenerative hyperplasia of the liver secondary to azathioprine in a patient with inflammatory bowel disease [Case report]. New Zealand Medical Journal, 123(1313). Retrieved from http:// www.nzma.org.nz/journal/archive.shtml Chew, J. S. C., Saleem, M., Florkowski, C. M., & George, P. M. (2009). Estimating renal function in oncology patients using cystatin C-based equations [Letter]. Clinical Oncology, 21, 425-426. doi: 10.1016/j.clon.2009.01.012 Connell, D. W., Singanayagam, A., Charif, R., George, P. M., Molyneaux, P. L., et al. (2010). A comparison between interferon gamma release assays and the tuberculin skin test in the contact tracing of patients with chronic kidney disease [Letter]. Thorax, Advance Online Publication. doi: 10.1136/thx.2010.149088 Davis, R. L., May, S., Chunilal, S., & Brennan, S. O. (2009). Two novel mutations at contiguous codons in the fibrinogen Bb chain associated with hypofibrinogenaemia [Letter to the editor]. Thrombosis and Haemostasis, 101(5), 980-982. doi: 10.1160/th08-11-0727 Doudney, K., Grinham, J., Whittaker, J., Lynch, S. A., Thompson, D., Moore, G. E., Copp, A. J., Greene, N. D. E., & Stanier, P. (2009). Evaluation of folate metabolism gene polymorphisms as risk factors for open and closed neural tube defects. American Journal of Medical Genetics: Part A, 149A(7), 1585-1589. doi: 10.1002/ajmg.a.32937

242 RESEARCH REPORT 2009/2010 Elder, P. A., Lewis, J. G., King, R. I., & Florkowski, C. M. (2009). An anomalous result from gel tubes for vitamin D [Letter to the editor]. Clinica Chimica Acta, 410, 95. doi: 10.1016/j.cca.2009.09.037 Florkowski, C., Hedley, J., Bickley, V., Hooper, A. J., Burnett, J. R., & George, P. (2010). Fatty infiltration of the liver in a case of hypobetalipoproteinaemia with a novel mutation in the APOB gene. New Zealand Medical Journal, 123(1310). Retrieved from http://www.nzma.org.nz/journal/archive.shtml Florkowski, C., Molyneux, S., George, P., Lever, M., & Richards, M. (2009). N-3 polyunsaturated fatty acids and statins in heart failure [Letter]. Lancet, 373(9661), 379-380. doi: 10.1016/S0140-6736(09)60129-X Fraser, R. (2010). Why teach human anatomy at Otago School of Medical Sciences? [Editorial]. New Zealand Medical Journal, 123(1312). Retrieved from http://www.nzma.org.nz/journal/archive.shtml Ganly, P., Downing, J., Stiven, P., Frizelle, F., & Badami, K. (2010). Clinical and serological diagnoses of a patient with vancomycin-induced thrombocytopenia [Letter to the editor]. Transfusion Medicine, Advance Online Publication. doi: 10.1111/j.1365-3148.2010.01052.x Jennings, L. C. (2009). Influenza A(H1N1)09: New Zealand’s response to the pandemic threat. New Zealand Medical Journal, 122(1298). Retrieved from http://www.nzma.org.nz/journal/122-1298/3700/ Jennings, L. C., Nicholson, K. G., & Monto, A. S. (2009). Prepandemic influenza vaccines: Authors’ reply [Letter]. Lancet Infectious Diseases, 9(4), 207-209. doi: 10.1016/S1473-3099(09)70084-2 Jina, H., Mercer, P., Gordon, M., Singh, H., & Whitehead, M. (2010). Angiomatosis: A case report. New Zealand Medical Journal, 123(1319). Retrieved from http://www.nzma.org.nz/journal/123-1319/4231/content.pdf Laurie, A. D., & Smith, M. P. (2009). Effect of the F8 mutation c.1538-2A>T on pre-mRNA splicing [Letter to the editor]. Haemophilia, 15(6), 1348-1350. doi: 10.1111/j.1365-2516.2009.02087.x Macdonald, C. A., Jardine, D. L., Hurrell, M. A., & Pithie, A. D. (2009). The worm that turned [Case report]. Transactions of the Royal Society of Tropical Medicine and Hygiene, 103(10), 1065-1067. doi: 10.1016/j.trstmh.2009.05.007 Mackenzie, K. A., Simcock, J. W., Lainchbury, J. G., Currie, M. J., & Lynn, K. L. (2009). Myocardial metastasis of cutaneous squamous cell carcinoma in a renal transplant recipient [Case report]. Transplantation Proceedings, 41(10), 4414-4415. Morris, C. M., & Jewell, U. R. (2010). Array of hope for high-resolution genetic screening services in New Zealand [Editorial]. New Zealand Medical Journal, 123(1318). Retrieved Murdoch, D. R., & Chambers, S. T. (2009). Atypical pneumonia: Time to breathe new life into a useful term? Lancet Infectious Diseases, 9(8), 512-519. Murdoch, D. R., O’Brien, K., Scott, J. A. G., Karron, R. A., Bhat, N., Driscoll, A. J., Knoll, M. D., & Levine, O. S. (2009). Breathing new life into pneumonia diagnostics [Commentary]. Journal of Clinical Microbiology, 47(11), 3405-3408. doi: 10.1128/jcm.01685-09 Stamp, L. K., O’Donnell, J. L., Barclay, M. L., Frampton, C., & Chapman, P. T. (2010). Response to comments [Letter to the editor]. Arthritis and Rheumatism, 62(8), 2560-2561. doi: 10.1002/art.27539 Stamp, L. K., O’Donnell, J. L., Chapman, P. T., Barclay, M. L., Kennedy, M. A., Frampton, C. M. A., & Roberts, R. L. (2009). Lack of association between HLA-G 14 bp insertion/deletion polymorphism and response to longterm therapy with methotrexate response in rheumatoid arthritis [Letter]. Annals of the Rheumatic Diseases, 68(1), 154-155. doi: 10.1136/ ard.2008.089383 Sykes, P., Miller, A., & Peddie, D. (2009). Unsatisfactory cervical cytology screening specimens are associated with missed cervical dysplasia and cancer [Author’s reply]. BJOG: An International Journal of Obstetrics and Gynaecology, 116(6), 867. doi: 10.1111/j.1471-0528.2009.02114.x Upton, J., & George, P. (2010). The prevalence of lactose intolerance (adult hypolactasia) in a randomly selected New Zealand population [Letter]. New Zealand Medical Journal, 123(1308). Retrieved from http://www.nzma.org.nz/ journal/123-1308/3970/content.pdf

Journal - Professional & Other Non-Research Articles Jennings, L. C. (2010). Symposium on viral respiratory disease surveillance [Editorial]. Influenza & Other Respiratory Viruses, 4(Suppl. 2), 1. doi: 10.1111/j.1750-2659.2010.00140.x Le Couteur, D. G., Cogger, V. C., Dobbs, B., & Fraser, R. (2010). Fenestrations and lipoproteins [Letter to the editor]. Cardiovascular Pathology, Advance Online Publication. doi: 10.1016/j.carpath.2010.04.007 Miller, A. (2010). [Review of the book Functional histology (2nd edition)]. New Zealand Medical Journal, 123(1321). Retrieved from http://www.nzma.org.nz/journal/123-1321/4321/content.pdf Morris, C. M., & Jewell, U. R. (2010). [Response by Morris and Jewell to the letter Discussion of Morris and Jewell’s editorial ‘Array of hope for high-resolution genetic screening services in New Zealand’]. New Zealand Medical Journal, 123(1319). Retrieved from http://www.nzma.org.nz/journal/archive.php Murdoch, D. R., & Levine, O. S. (2009). Time to focus on the prevention of childhood pneumonia [Editorial]. Internal Medicine Journal, 39(11), 711-712. doi: 10.1111/j.1445-5994.2009.02054.x Wilson, N., Baker, M., Jennings, L., Murdoch, D., Krause, K., Edwards, R., Roberts, M., Pearce, N., Douwes, J., Johnston, D., & Rice, G. (2009). A design fault in New Zealand’s health research funding system exposed by pandemic influenza [Letter]. New Zealand Medical Journal, 122(1304). Retrieved from http://www.nzma.org.nz/journal/122-1304/3839/

Division of HEALTH SCIENCES 243 University of Otago, Christchurch Department of Psychological Medicine

Authored Book - Research Cave, T., Robertson, P., Pitama, S., & Huriwai, T. (2009). He tete kura: Maori addiction treatment: 1980-2008. Wellington, New Zealand: Matua Raki, 203p.

Chapter in Book - Research Crowe, M., & Carlyle, D. (2009). The person with a diagnosis of personality disorder. In P. Barker (Ed.), Psychiatric and mental health nursing: The craft of caring (2nd ed.). (pp. 244-251). London: Hodder Arnold. Fergusson, D. M. (2009). Prevention, treatment and management of conduct problems in childhood and adolescence. In G. Maxwell (Ed.), Addressing the causes of offending: What is the evidence? (pp. 103-114). Wellington, New Zealand: Institute of Policy Studies. McIntosh, V. V. W., & Jordan, J. (2009). Specialist supportive clinical management for anorexia nervosa. In S. J. Paxton & P. J. Hay (Eds.), Interventions for body image and eating disorders: Evidence and practice (pp. 75-94). Melbourne, Australia: IP Communications.

Journal - Research Article Adamson, S. J., Heather, N., Morton, V., & Raistrick, D. (2010). Initial preference for drinking goal in the treatment of alcohol problems: II. Treatment outcomes. Alcohol and Alcoholism, 45(2), 136-142. doi: 10.1093/alcalc/agq005 Adamson, S. J., Kay-Lambkin, F. J., Baker, A. L., Lewin, T. J., Thornton, L., Kelly, B. J., & Sellman, J. D. (2010). An improved brief measure of cannabis misuse: The Cannabis Use Disorders Identification Test-Revised (CUDIT-R). Drug and Alcohol Dependence, 110, 137-143. doi: 10.1016/j.drugalcdep.2010.02.017 Adamson, S. J., Sellman, J. D., & Frampton, C. M. A. (2009). Patient predictors of alcohol treatment outcome: A systematic review. Journal of Substance Abuse Treatment, 36(1), 75-86. doi: 10.1016/j.jsat.2008.05.007 Adamson, S. J., & Todd, F. C. (2010). Drug use is a health issue. New Zealand Medical Journal, 123(1327). Retrieved from http://www.nzma.org.nz/journal/123-1327/4479/ Argyropoulos, S. V., Hicks, J. A., Nash, J. R., Bell, C. J., Rich, A. S., Nutt, D. J., & Wilson, S. (2009). Redistribution of slow wave activity of sleep during pharmacological treatment of depression with paroxetine but not with nefazodone. Journal of Sleep Research, 18(3), 342-348. doi: 10.1111/j.1365-2869.2008.00724.x Atkinson, W., Slow, S., Elmslie, J., Lever, M., Chambers, S. T., & George, P. M. (2009). Dietary and supplementary betaine: Effects on betaine and homocysteine concentrations in males. Nutrition, Metabolism and Cardiovascular Diseases, 19(11), 767-776. doi: 10.1016/j.numecd.2009.01.004 Beautrais, A. L., Gibb, S. J., Faulkner, A., Fergusson, D. M., & Mulder, R. T. (2010). Postcard intervention for repeat self-harm: Randomised controlled trial. British Journal of Psychiatry, 197(1), 55-60. doi: 10.1192/bjp.bp.109.075754 Beautrais, A. L., Gibb, S. J., Fergusson, D. M., Horwood, L. J., & Larkin, G. L. (2009). Removing bridge barriers stimulates suicides: An unfortunate natural experiment. Australian and New Zealand Journal of Psychiatry, 43(6), 495-497. Bell, C., Bourke, C., Colhoun, H., Carter, F., Frampton, C., & Porter, R. (2010). The misclassification of facial expressions in generalised social phobia. Journal of Anxiety Disorders, Advance Online Publication. doi: 10.1016/j.janxdis.2010.10.001 Boden, J. M., Fergusson, D. M., & Horwood, L. J. (2009). Experience of sexual abuse in childhood and abortion in adolescence and early adulthood. Child Abuse and Neglect, 33, 870-876. doi: 10.1016/j.chiabu.2009.04.006 Boden, J. M., Fergusson, D. M., & Horwood, L. J. (2010). Alcohol and STI risk: Evidence from a New Zealand longitudinal birth cohort. Drug and Alcohol Dependence, Advance Online Publication. doi: 10.1016/j.drugalcdep.2010.08.005 Boden, J. M., Fergusson, D. M., & Horwood, L. J. (2010). Cigarette smoking and depression: Tests of causal linkages using a longitudinal birth cohort. British Journal of Psychiatry, 196(6), 440-446. doi: 10.1192/bjp.bp.109.065912 Boden, J. M., Fergusson, D. M., & Horwood, L. J. (2010). Risk factors for conduct disorder and oppositional/defiant disorder: Evidence from a New Zealand Birth Cohort. Journal of the American Academy of Child and Adolescent Psychiatry, 49(11), 1125-1133. doi: 10.1016/j.jaac.2010.08.005 Borges, G., Nock, M. K., Haro Abad, J. M., Hwang, I., Sampson, N. A., ..., Beautrais, A., et al. (2010). Twelve-month prevalence of and risk factors for suicide attempts in the World Health Organization World Mental Health Surveys. Journal of Clinical Psychiatry, 71(12), 1617-1628. doi: 10.4088/JCP.08m04967blu Bourke, C., Douglas, K., & Porter, R. (2010). Processing of facial emotion expression in major depression: A review. Australian and New Zealand Journal of Psychiatry, 44(8), 681-696. doi: 10.3109/00048674.2010.496359 Campbell, S. D., Adamson, S. J., & Carter, J. D. (2010). Client language during motivational enhancement therapy and alcohol use outcome. Behavioural and Cognitive Psychotherapy, 38, 399-415. doi: 10.1017/S1352465810000263 Carter, F. A., Jordan, J., McIntosh, V. V. W., Luty, S. E., McKenzie, J. M., Frampton, C. M. A., Bulik, C. M., & Joyce, P. R. (2010). The long-term efficacy of three psychotherapies for anorexia nervosa: A randomized, controlled trial. International Journal of Eating Disorders, Advance Online Publication. doi: 10.1002/eat.20879 Carter, J. D., Frampton, C. M. A., Mulder, R. T., Luty, S. E., McKenzie, J. M., & Joyce, P. R. (2009). Rumination: Relationship to depression and personality in a clinical sample. Personality and Mental Health, 3, 275-283. doi: 10.1002/pmh.91 Carter, J. D., Frampton, C. M., Mulder, R. T., Luty, S. E., & Joyce, P. R. (2010). The relationship of demographic, clinical, cognitive and personality variables to the discrepancy between self and clinician rated depression. Journal of Affective Disorders, 124(1-2), 202-206. doi: 10.1016/j.jad.2009.11.011

244 RESEARCH REPORT 2009/2010 Carter, J. D., Luty, S. E., McKenzie, J. M., Mulder, R. T., Frampton, C. M., & Joyce, P. R. (2010). Patient predictors of response to cognitive behaviour therapy and interpersonal psychotherapy in a randomised clinical trial for depression. Journal of Affective Disorders, Advance Online Publication. doi: 10.1016/j.jad.2010.07.002 Crowe, M., Inder, M., Joyce, P., Moor, S., Carter, J., & Luty, S. (2009). A developmental approach to the treatment of bipolar disorder: IPSRT with an adolescent. Journal of Clinical Nursing, 18(1), 141-149. doi: 10.1111/j.1365-2702.2008.02571.x Crowe, M., Whitehead, L., Gagan, M. J., Baxter, D., & Panckhurst, A. (2010). Self-management and chronic low back pain: A qualitative study. Journal of Advanced Nursing, 66(7), 1478-1486. doi: 10.1111/j.1365-2648.2010.05316.x Crowe, M., Whitehead, L., Wilson, L., Carlyle, D., O’Brien, A., Inder, M., & Joyce, P. (2010). Disorder-specific psychosocial interventions for bipolar disorder-A systematic review of the evidence for mental health nursing practice. International Journal of Nursing Studies, 47, 896-908. doi: 10.1016/j.ijnurstu.2010.02.012 Dalrymple-Alford, J. C., MacAskill, M. R., Nakas, C. T., Livingston, L., Graham, C., Crucian, G. P., Melzer, T. R., Kirwan, J., Keenan, R., Wells, S., Porter, R. J., Watts, R., & Anderson, T. J. (2010). The MoCA: Well-suited screen for cognitive impairment in Parkinson disease. Neurology, 75(19), 1717-1725. doi: 10.1212/WNL.0b013e3181fc29c9 Darlow, B. A., Horwood, L. J., Wynn-Williams, M. B., Mogridge, N., & Austin, N. C. (2009). Admissions of all gestations to a regional neonatal unit versus controls: 2-year outcome. Journal of Paediatrics and Child Health, 45(4), 187-193. doi: 10.1111/j.1440-1754.2008.01457.x Darlow, B. A., Mogridge, N., Horwood, L. J., Wynn-Williams, M. B., & Austin, N. C. (2009). Admission of all gestations to a regional neonatal unit versus controls: Neonatal morbidity. Journal of Paediatrics and Child Health, 45(4), 181-186. doi: 10.1111/j.1440-1754.2009.01486.x Doudney, K., Harley, J. A., Pearson, J. F., Miller, A., Aitchison, A., Kennedy, M. A., Porter, R. J., Elmslie, J. L., & Joyce, P. R. (2009). Upstream genetic variant near INSIG2, influences response to carnitine supplementation in bipolar patients with valproate-induced weight gain. Acta Neuropsychiatrica, 21(3), 133-140. doi: 10.1111/j.1601-5215.2009.00379.x Douglas, K. M., & Porter, R. J. (2009). Longitudinal assessment of neuropsychological function in major depression. Australian and New Zealand Journal of Psychiatry, 43(12), 1105-1117. doi: 10.3109/00048670903279887 Douglas, K. M., & Porter, R. J. (2010). Recognition of disgusted facial expressions in severe depression. British Journal of Psychiatry, 197, 156-157. doi: 10.1192/bjp.bp.110.078113 Douglas, K. M., Porter, R. J., Frampton, C. M., Gallagher, P., & Young, A. H. (2009). Abnormal response to failure in unmedicated major depression. Journal of Affective Disorders, 119, 92-99. doi: 10.1016/j.jad.2009.02.018 Dowson, C. A., Kuijer, R. G., Town, I. G., & Mulder, R. T. (2010). Impact of panic disorder upon self-management educational goals in chronic obstructive pulmonary disease? Chronic Respiratory Disease, 7(2), 83-90. doi: 10.1177/1479972310365363 Durrant, R., Adamson, S., Todd, F., & Sellman, D. (2009). Drug use and addiction: Evolutionary perspective. Australian and New Zealand Journal of Psychiatry, 43(11), 1049-1056. Elmslie, J. L., Porter, R. J., Joyce, P. R., Hunt, P. J., Shand, B. I., & Scott, R. S. (2009). Comparison of insulin resistance, metabolic syndrome and adiponectin in overweight bipolar patients taking sodium valproate and controls. Australian and New Zealand Journal of Psychiatry, 43(1), 53-60. doi: 10.1080/00048670802534341 Fergusson, D. M., Boden, J. M., & Horwood, L. J. (2009). Situational and generalised conduct problems and later life outcomes: Evidence from a New Zealand birth cohort. Journal of Child Psychology and Psychiatry and Allied Disciplines, 50(9), 1084- 1092. doi: 10.1111/j.1469-7610.2009.02070.x Fergusson, D. M., Boden, J. M., & Horwood, L. J. (2009). Tests of causal links between alcohol abuse or dependence and major depression. Archives of General Psychiatry, 66(3), 260-266. Fergusson, D. M., Boden, J. M., & Horwood, L. J. (2010). Classification of behavior disorders in adolescence: Scaling methods, predictive validity, and gender differences. Journal of Abnormal Psychology, 119(4), 699-712. doi: 10.1037/a0018610 Fergusson, D. M., Boden, J. M., & Horwood, L. J. (2010). Structural models of the comorbidity of internalizing disorders and substance use disorders in a longitudinal birth cohort. Social Psychiatry and Psychiatric Epidemiology, Advance Online Publication. doi: 10.1007/s00127-010-0268-1 Fergusson, D. M., Horwood, L. J., & Boden, J. M. (2009). Reactions to abortion and subsequent mental health. British Journal of Psychiatry, 195(5), 420-426. doi: 10.1192/bjp.bp.109.066068 Fernando, K., & Medlicott, L. (2009). My shield will protect me against the ANTS: Treatment of PTSD in a client with an intellectual disability [Case report]. Journal of Intellectual & Developmental Disability, 34(2), 187-192. doi: 10.1080/13668250902845228 Friesen, M. D., Woodward, L. J., Horwood, L. J., & Fergusson, D. M. (2010). Childhood exposure to sexual abuse and partnership outcomes at age 30. Psychological Medicine, 40, 679-688. doi: 10.1017/S0033291709990389 Gibb, S. J., Beautrais, A. L., & Surgenor, L. J. (2010). Health-care staff attitudes towards self-harm patients. Australian and New Zealand Journal of Psychiatry, 44(8), 713-720. doi: 10.3109/00048671003671015 Gibb, S. J., & Fergusson, D. M. (2009). Research note: Gender differences in educational participation and achievement across subject areas. New Zealand Journal of Educational Studies, 44(1), 83-91. Gibb, S. J., Fergusson, D. M., & Horwood, L. J. (2010). Burden of psychiatric disorder in young adulthood and life outcomes at age 30. British Journal of Psychiatry, 197, 122-127. doi: 10.1192/bjp.bp.109.076570 Gibb, S. J., Fergusson, D. M., & Horwood, L. J. (2010). Relationship separation and mental health problems: Findings from a 30-year longitudinal study. Australian and New Zealand Journal of Psychiatry, Advance Online Publication. doi: 10.3109/00048674.2010.529603 Gilbert, R., Spatz Widom, C., Browne, K., Fergusson, D., Webb, E., & Janson, S. (2009). Burden and consequences of child maltreatment in high-income countries. Lancet, 373(9657), 68-81. doi: 10.1016/S0140-6736(08)61706-7

Division of HEALTH SCIENCES 245 Glubb, D. M., Joyce, P. R., & Kennedy, M. A. (2009). Expression and association analyses of promoter variants of the neurogenic gene HES6, a candidate gene for mood disorder susceptibility and antidepressant response. Neuroscience Letters, 460, 185-190. doi: 10.1016/j.neulet.2009.05.065 Glubb, D. M., McHugh, P. C., Deng, X., Joyce, P. R., & Kennedy, M. A. (2010). Association of a functional polymorphism in the adrenomedullin gene (ADM) with response to paroxetine. Pharmacogenomics Journal, 10, 126-133. doi: 10.1038/ tpj.2009.33 Gureje, O., Oladeji, B., Hwang, I., Chiu, W. T., Kessler, R. C., ..., Beautrais, A., et al. (2010). Parental psychopathology and the risk of suicidal behavior in their offspring: Results from the World Mental Health surveys. Molecular Psychiatry, Advance Online Publication. doi: 10.1038/mp.2010.111 Harley, J., Roberts, R., Joyce, P., Mulder, R., Luty, S., Frampton, C., & Kennedy, M. (2010). Orosomucoid influences the response to antidepressants in major depressive disorder. Journal of Psychopharmacology, 24(4), 531-535. doi: 10.1177/0269881109105101 Heather, N., Adamson, S. J., Raistrick, D., & Slegg, G. P. (2010). Initial preference for drinking goal in the treatment of alcohol problems: I. Baseline differences between abstinence and non-abstinence groups. Alcohol and Alcoholism, 45(2), 128-135. doi: 10.1093/alcalc/agp096 Horwood, L. J., Fergusson, D. M., Hayatbakhsh, M. R., Najman, J. M., Coffey, C., Patton, G. C., et al. (2010). Cannabis use and educational achievement: Findings from three Australasian cohort studies. Drug and Alcohol Dependence, Advance Online Publication. doi: 10.1016/j.drugalcdep.2010.03.008 Inder, M. L., Crowe, M. T., Joyce, P. R., Moor, S., Carter, J. D., & Luty, S. E. (2010). ²I really don’t know whether it is still there²: Ambivalent acceptance of a diagnosis of bipolar disorder. Psychiatric Quarterly, Advance Online Publication. doi: 10.1007/ s11126-010-9125-3 Johnstone, J. M., Luty, S. E., Carter, J. D., Mulder, R. T., Frampton, C. M. A., & Joyce, P. R. (2009). Childhood neglect and abuse as predictors of antidepressant response in adult depression. Depression and Anxiety, 26(8), 711-717. doi: 10.1002/ da.20590 Jordan, J., Joyce, P. R., Carter, F. A., McIntosh, V. V. W., Luty, S. E., McKenzie, J. M., Frampton, C. M. A., & Bulik, C. M. (2009). The Yale-Brown-Cornell Eating Disorder Scale in women with anorexia nervosa: What is it measuring? International Journal of Eating Disorders, 42(3), 267-274. doi: 10.1002/eat.20605 Joyce, P. R., Light, K. J., Rowe, S. L., Cloninger, C. R., & Kennedy, M. A. (2010). Self-mutilation and suicide attempts: Relationships to bipolar disorder, borderline personality disorder, temperament and character. Australian and New Zealand Journal of Psychiatry, 44(3), 250-257. doi: 10.3109/00048670903487159 Joyce, P. R., McHugh, P. C., Light, K. J., Rowe, S., Miller, A. L., & Kennedy, M. A. (2009). Relationships between angry-impulsive personality traits and genetic polymorphisms of the dopamine transporter. Biological Psychiatry, 66(8), 717-721. doi: 10.1016/j.biopsych.2009.03.005 Larkin, G. L., Beautrais, A. L., Spirito, A., Kirrane, B. M., Lippmann, M. J., & Milzman, D. P. (2009). Mental health and emergency medicine: A research agenda. Academic Emergency Medicine, 16(11), 1110-1119. doi: 10.1111/j.1553- 2712.2009.00545.x Le Strat, Y., Ramoz, N., Horwood, J., Falissard, B., Hassler, C., Romo, L., Choquet, M., Fergusson, D. M., & Gorwood, P. (2009). First positive reactions to cannabis constitute a priority risk factor for cannabis dependence. Addiction, 104(10), 1710- 1717. doi: 10.1111/j.1360-0443.2009.02680.x Lever, M., George, P. M., Slow, S., Elmslie, J. L., Scott, R. S., Richards, A. M., Fink, J. N., & Chambers, S. T. (2009). Fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine. Cardiovascular Drugs and Therapy, 23(5), 395-401. doi: 10.1007/s10557-009-6188-1 Lever, M., George, P. M., Slow, S., Elmslie, J. L., Shand, B. I., Scott, R. S., & Chambers, S. T. (2010). Fibrates plus betaine: A winning combination? [Viewpoint]. New Zealand Medical Journal, 123(1324). Retrieved from http://www.nzma.org.nz/ journal/123-1324/4389/content.pdf Light, K. J., Joyce, P. R., & Frampton, C. M. A. (2009). Description and validation of the Affective Temperament Questionnaire. Comprehensive Psychiatry, 50(5), 477-484. doi: 10.1016/j.comppsych.2007.07.008 Mace, J. L., Porter, R. J., Dalrymple-Alford, J. C., & Anderson, T. J. (2010). The effects of acute tryptophan depletion on mood in patients with Parkinson’s disease and the healthy elderly. Journal of Psychopharmacology, 24(4), 615-619. doi: 10.1177/0269881109105572 Mace, J. L., Porter, R. J., Dalrymple-Alford, J. C., Wesnes, K. A., & Anderson, T. J. (2010). Effects of acute tryptophan depletion on neuropsychological and motor function in Parkinson’s disease. Journal of Psychopharmacology, 24(10), 1465-1472. doi: 10.1177/0269881109105721 MacMillan, H. L., Wathen, C. N., Barlow, J., Fergusson, D. M., Leventhal, J. M., & Taussig, H. N. (2009). Interventions to prevent child maltreatment and associated impairment. Lancet, 373(9659), 250-266. doi: 10.1016/S0140-6736(08)61708-0 Malhi, G., Adams, D., Bernardi, E., Miller, M., Mulder, R., Walter, G., & Smith, B. (2010). Time to ‘get real’: Preliminary insights into the long-term management of schizophrenia. Australasian Psychiatry, 18(2), 115-119. doi: 10.3109/10398560903450866 Malhi, G. S., Adams, D., Lampe, L., ..., Porter, R., Mulder, R. T., et al. (2009). Clinical practice recommendations for bipolar disorder. Acta Psychiatrica Scandinavica, 119(Suppl. 439), 27-46. doi: 10.1111/j.1600-0447.2009.01383.x Malhi, G. S., Adams, D., Porter, R., ..., Mulder, R. T., et al. (2009). Clinical practice recommendations for depression. Acta Psychiatrica Scandinavica, 119(Suppl. 439), 8-26. doi: 10.1111/j.1600-0447.2009.01382.x

246 RESEARCH REPORT 2009/2010 Marie, D., Fergusson, D. M., & Boden, J. M. (2009). Ethnic identity and criminal offending in a New Zealand birth cohort. Australian & New Zealand Journal of Criminology, 42(3), 354-368. doi: 10.1375/acri.42.3.354 Marie, D., Fergusson, D. M., & Boden, J. M. (2009). Ethnic identity and exposure to maltreatment in childhood: Evidence from a New Zealand Birth Cohort. Social Policy Journal of New Zealand, (36), 154-171. Marie, D., Fergusson, D. M., & Boden, J. M. (2010). Does socioeconomic inequality explain ethnic differences in nicotine dependence? Evidence from a New Zealand birth cohort. Australian and New Zealand Journal of Psychiatry, 44(4), 378- 383. doi: 10.3109/00048670903489908 Maskill, V., Crowe, M., Luty, S., & Joyce, P. (2010). Two sides of the same coin: Caring for a person with bipolar disorder. Journal of Psychiatric and Mental Health Nursing, 17(6), 535-542. doi: 10.1111/j.1365-2850.2010.01555.x McHugh, P. C., Joyce, P. R., Deng, X., & Kennedy, M. A. (2010). A polymorphism of the GTP-cyclohydrolase I feedback regulator gene alters transcriptional activity and may affect response to SSRI antidepressants. Pharmacogenomics Journal, Advance Online Publication. doi: 10.1038/tpj.2010.23 McHugh, P. C., Joyce, P. R., & Kennedy, M. A. (2009). Polymorphisms of sepiapterin reductase gene alter promoter activity and may influence risk of bipolar disorder. Pharmacogenetics and Genomics, 19(5), 330-337. doi: 10.1097/ FPC.0b013e328328f82c McHugh, P. C., Rogers, G. R., Glubb, D. M., Joyce, P. R., & Kennedy, M. A. (2010). Proteomic analysis of rat hippocampus exposed to the antidepressant paroxetine. Journal of Psychopharmacology, 24(8), 1243-1251. doi: 10.1177/0269881109102786 McIntosh, V. V. W., Carter, F. A., Bulik, C. M., Frampton, C. M. A., & Joyce, P. R. (2010). Five-year outcome of cognitive behavioral therapy and exposure with response prevention for bulimia nervosa. Psychological Medicine, Advance Online Publication. doi: 10.1017/S0033291710001583 McKinlay, A., Grace, R. C., Horwood, L. J., Fergusson, D. M., & MacFarlane, M. R. (2010). Long-term behavioural outcomes of pre-school mild traumatic brain injury. Child Care Health and Development, 36(1), 22-30. doi: 10.1111/j.1365- 2214.2009.00947.x McKinlay, A., Grace, R., Horwood, J., Fergusson, D., & MacFarlane, M. (2009). Adolescent psychiatric symptoms following preschool childhood mild traumatic brain injury: Evidence from a birth cohort. Journal of Head Trauma Rehabilitation, 24(3), 221-227. doi: 10.1097/HTR.0b013e3181e67936 McKinlay, A., Kyonka, E. G. E., Grace, R. C., Horwood, L. J., Fergusson, D. M., & MacFarlane, M. (2010). An investigation of the pre-injury risk factors associated with children who experience traumatic brain injury. Injury Prevention, 16(1), 31-35. doi: 10.1136/ip.2009.022483 McLellan, T., Johnston, L., Dalrymple-Alford, J., & Porter, R. (2010). Sensitivity to genuine versus posed emotion specified in facial displays. Cognition & Emotion, 24(8), 1277-1292. doi: 10.1080/02699930903306181 Mulder, R. T., Frampton, C. M. A., Luty, S. E., & Joyce, P. R. (2009). Eighteen months of drug treatment for depression: Predicting relapse and recovery. Journal of Affective Disorders, 114(1-3), 263-270. doi: 10.1016/j.jad.2008.08.002 Mulder, R. T., Frampton, C. M. A., Peka, H., Hampton, G., & Marsters, T. (2009). Predictors of 3-month retention in a drug treatment therapeutic community. Drug and Alcohol Review, 28(4), 366-371. doi: 10.1111/j.1465-3362.2009.00050.x Mulder, R. T., Joyce, P. R., & Frampton, C. M. A. (2009). Personality disorders improve in patients treated for major depression. Acta Psychiatrica Scandinavica, 122, 219-225. doi: 10.1111/j.1600-0447.2009.01502.x Nock, M. K., Hwang, I., Sampson, N., Kessler, R. C., Angermeyer, M. C., Beautrais, A., et al. (2009). Cross-national analysis of the associations among mental disorders and suicidal behavior: Findings from the WHO World Mental Health Surveys. PLoS Medicine, 6(8). doi: 10.1371/journal.pmed.1000123 Oakley Browne, M. A., Wells, J. E., Scott, K. M., McGee, M. A., & New Zealand Mental Health Survey Research Team (2010). The Kessler Psychological Distress Scale in Te Rau Hinengaro: The New Zealand Mental Health Survey. Australian and New Zealand Journal of Psychiatry, 44(4), 314-322. doi: 10.3109/00048670903279820 Pagey, B., Deering, D., & Sellman, D. (2010). Retention of adolescents with substance dependence and coexisting mental health disorders in outpatient alcohol and drug group therapy. International Journal of Mental Health Nursing, 19(6), 437-444. doi: 10.1111/j.1447-0349.2010.00693.x Pandya, A., Larkin, G. L., Randles, R., Beautrais, A. L., & Smith, R. P. (2009). Epidemiological trends in psychosis-related Emergency Department visits in the United States, 1992-2001. Schizophrenia Research, 110(1-3), 28-32. doi: 10.1016/j. schres.2008.12.015 Rowe, S., Jordan, J., McIntosh, V., Carter, F., Frampton, C., Bulik, C., & Joyce, P. (2010). Dimensional measures of personality as a predictor of outcome at 5-year follow-up in women with bulimia nervosa. Psychiatry Research, Advance Online Publication. doi: 10.1016/j.psychres.2010.07.017 Rowe, S. L., Jordan, J., McIntosh, V. V. W., Carter, F. A., Frampton, C., Bulik, C. M., & Joyce, P. R. (2010). Complex personality disorder in bulimia nervosa. Comprehensive Psychiatry, Advance Online Publication. doi: 10.1016/j. comppsych.2010.02.012 Rowe, S. L., Jordan, J., McIntosh, V. V. W., Carter, F. A., Frampton, C., Bulik, C. M., & Joyce, P. R. (2010). Does avoidant personality disorder impact on the outcome of treatment for bulimia nervosa? International Journal of Eating Disorders, 43(5), 420-427. doi: 10.1002/eat.20716 Schroder, R., Sellman, D., & Elmslie, J. (2010). Addictive overeating: Lessons learned from medical students’ perceptions of Overeaters Anonymous. New Zealand Medical Journal, 123(1311). Retrieved from http://www.nzma.org.nz/ journal/123-1311/4033/

Division of HEALTH SCIENCES 247 Schroder, R., Sellman, D., Frampton, C. M., & Deering, D. (2009). Youth retention: Factors associated with treatment drop-out from youth alcohol and other drug treatment. Drug and Alcohol Review, 28(6), 663-668. doi: 10.1111/j.1465- 3362.2009.00076.x Scott, K. M., Oakley Browne, M. A., & Wells, J. E. (2010). Prevalence, impairment and severity of 12-month DSM-IV major depressive episodes in Te Rau Hinengaro: New Zealand Mental Health Survey 2003/4. Australian and New Zealand Journal of Psychiatry, 44(8), 750-758. doi: 10.3109/00048671003781780 Sellman, D., & Connor, J. (2009). In utero brain damage from alcohol: A preventable tragedy. New Zealand Medical Journal, 122(1306). Retrieved from http://www.nzma.org.nz/journal/122-1306/3888/ Sellman, J. D., Robinson, G. M., & Beasley, R. (2009). Should ethanol be scheduled as a drug of high risk to public health? Journal of Psychopharmacology, 23(1), 94-100. doi: 10.1177/0269881108091596 Slade, P., Morrell, C. J., Rigby, A., Ricci, K., Spittlehouse, J., & Brugha, T. S. (2010). Postnatal women’s experiences of management of depressive symptoms: A qualitative study. British Journal of General Practice, 60(580), e440-e448. doi: 10.3399/bjgp10X532611 Snell, D. L., Siegert, R. J., Hay-Smith, E. J. C., & Surgenor, L. J. (2010). An examination of the factor structure of the Revised Illness Perception Questionnaire modified for adults with mild traumatic brain injury. Brain Injury, 24(13-14), 1595-1605. doi: 10.3109/02699052.2010.523048 Snell, D. L., Surgenor, L. J., Hay-Smith, E. J. C., & Siegert, R. J. (2009). A systematic review of psychological treatments for mild traumatic brain injury: An update on the evidence. Journal of Clinical and Experimental Neuropsychology, 31(1), 20-38. doi: 10.1080/13803390801978849 Snell, L., Crowe, M., & Jordan, J. (2010). Maintaining a therapeutic connection: Nursing in an inpatient eating disorder unit. Journal of Clinical Nursing, 19(3/4), 351-358. doi: 10.1111/j.1365-2702.2009.03000.x Soh, N. L-W., Touyz, S. W., Dobbins, T. A., Surgenor, L. J., Clarke, S., Kohn, M. R., Lee, E. L., Leow, V., et al. (2009). Nutrition knowledge in young women with eating disorders in Australia and Singapore: A pilot study. Australian and New Zealand Journal of Psychiatry, 43(12), 1178-1184. doi: 10.3109/00048670903279846 Spittlehouse, J. K., Pearson, J. F., Luty, S. E., Mulder, R. T., Carter, J. D., McKenzie, J. M., & Joyce, P. R. (2010). Measures of temperament and character are differentially impacted on by depression severity. Journal of Affective Disorders, 126, 140- 146. doi: 10.1016/j.jad.2010.03.010 Surgenor, L. J., Spearing, R. L., Horn, J., Beautrais, A. L., Mulder, R. T., & Chen, P. (2009). Burnout in hospital-based medical consultants in the New Zealand public health system. New Zealand Medical Journal, 122(1300). Retrieved from http:// www.nzma.org.nz/journal/122-1300/3737/ Thomas, A. J., Gallagher, P., Robinson, L. J., Porter, R. J., Young, A. H., Ferrier, I. N., & O’Brien, J. T. (2009). A comparison of neurocognitive impairment in younger and older adults with major depression. Psychological Medicine, 39, 725-733. doi: 10.1017/S0033291708004042 Turner, M. A., Boden, J. M., Smith-Hamel, C., & Mulder, R. T. (2009). Outcomes for 236 patients from a 2-year early intervention in psychosis service. Acta Psychiatrica Scandinavica, 120(2), 129-137. doi: 10.1111/j.1600-0447.2009.01386.x Tyrer, P., Mulder, R., Crawford, M., Newton-Howes, G., Simonsen, E., Ndetei, D., Koldobsky, N., et al. (2010). Personality disorder: A new global perspective. World Psychiatry, 9(1), 56-60. Wells, J. E., McGee, M. A., & Beautrais, A. L. (2010). Multiple aspects of sexual orientation: Prevalence and sociodemographic correlates in a New Zealand National Survey. Archives of Sexual Behavior, Advance Online Publication. doi: 10.1007/ s10508-010-9636-x Wells, J. E., McGee, M. A., Scott, K. M., & Oakley-Browne, M. A. (2010). Bipolar disorder with frequent mood episodes in the New Zealand Mental Health Survey. Journal of Affective Disorders, 126(1-2), 65-74. doi: 10.1016/j.jad.2010.02.136 Wheeler, A., Humberstone, V., Robinson, E., Sheridan, J., & Joyce, P. (2009). Impact of audit and feedback on antipsychotic prescribing in schizophrenia. Journal of Evaluation in Clinical Practice, 15(3), 441-450. doi: 10.1111/j.1365- 2753.2008.01032.x Wijnveld, A-M., & Crowe, M. (2010). Walking a fine line: Managing the tensions associated with medication non-adherence in an acute inpatient psychiatric setting. Journal of Clinical Nursing, 19(9-10), 1378-1386. doi: 10.1111/j.1365- 2702.2009.03029.x Wilson, L., & Crowe, M. (2009). Parenting with a diagnosis bipolar disorder. Journal of Advanced Nursing, 65(4), 877-884. doi: 10.1111/j.1365-2648.2008.04954.x Wong, P. W. C., Liu, P. M. Y., Chan, W. S. C., Law, Y. W., Law, S. C. K., Fu, K-W., Li, H. S. H., Tso, M. K., Beautrais, A. L., & Yip, P. S. F. (2009). An integrative suicide prevention program for visitor charcoal burning suicide and suicide pact. Suicide and Life-Threatening Behavior, 39(1), 82-90. doi: 10.1521/suli.2009.39.1.82 Woodward, L. J., Moor, S., Hood, K. M., Champion, P. R., Foster-Cohen, S., Inder, T. E., & Austin, N. C. (2009). Very preterm children show impairments across multiple neurodevelopmental domains by age 4 years. Archives of Disease in Childhood: Fetal and Neonatal Edition, 94(5), 339-344. doi: 10.1136/adc.2008.146282

Journal - Research Other Adamson, S. J., & Wells, J. E. (2009). Hazardous drinking: Not just an issue for the minority of drinkers [Editorial]. New Zealand Medical Journal, 122(1306). Retrieved from http://www.nzma.org.nz/journal/archive.shtml Beautrais, A. (2009). Crisis: Looking back down the road [Editorial]. Crisis: The Journal of Crisis Intervention and Suicide Prevention, 30(1), 1-5. doi: 10.1027/0227-5910.30.1.1

248 RESEARCH REPORT 2009/2010 Boden, J. M. (2009). Sex differences in the developmental antecedents of aggression [Discussion]. Behavioral and Brain Sciences, 32(3-4), 269-270. doi: 10.1017/s0140525x0900140x Cantor, C., & Joyce, P. R. (2009). Evolution and psychiatry [Editorial]. Australian and New Zealand Journal of Psychiatry, 43(11), 991-993. doi: 10.1080/00048670903360380 Croucher, M. (2010). Geriatric medicine is becoming the core of hospital business [Editorial]. New Zealand Medical Journal, 123(1317). Retrieved from http://www.nzmj.org/journal/ Fergusson, D. (2009). [Author’s reply to Abortion and mental health disorders]. British Journal of Psychiatry, 194(6), 570-571. doi: 10.1192/bjp.194.6.570b Fergusson, D. M. (2010). Is there a causal linkage between cannabis use and increased risks of psychotic symptoms? [Commentary]. Addiction, 105(8), 1336-1337. doi: 10.1111/j.1360-0443.2010.02959.x Fergusson, D. M., & Boden, J. M. (2009). [Authors reply to Abortion and mental health: Established facts reconsidered]. British Journal of Psychiatry, 195(2), 181-182. doi: 10.1192/bjp.195.2.181a Fergusson, D. M., Horwood, L. J., & Boden, J. M. (2009). Abortion and mental health [Correspondence]. British Journal of Psychiatry, 194(4), 377-378. doi: 10.1192/bjp.194.4.377b Fergusson, D., Stanley, L., & Horwood, L. J. (2009). Preliminary data on the efficacy of the incredible years basic parent programme in New Zealand. Australian and New Zealand Journal of Psychiatry, 43(1), 76-79. doi: 10.1080/00048670802534382 Harley, J., Luty, S., Carter, J., Mulder, R., & Joyce, P. (2010). Elevated C-reactive protein in depression: A predictor of good long-term outcome with antidepressants and poor outcome with psychotherapy [Letter to the editors]. Journal of Psychopharmacology, 24(4), 625-626. doi: 10.1177/0269881109102770 Larkin, G. L., & Beautrais, A. L. (2010). Emergency departments are underutilized sites for suicide prevention [Editorial]. Crisis, 31(1), 1-6. doi: 10.1027/0227-5910/a000001 Meyer, R. E., Salzman, C., Youngstrom, E. A., ..., Beautrais, A. L., et al. (2010). Suicidality and risk of suicide: Definition, drug safety concerns, and a necessary target for drug development: A consensus statement. Journal of Clinical Psychiatry, 71(8), e1-e21. doi: 10.4088/JCP.10cs06070blu Meyer, R. E., Salzman, C., Youngstrom, E. A., ..., Beautrais, A. L., et al. (2010). Suicidality and risk of suicide: Definition, drug safety concerns, and a necessary target for drug development: A brief report. Journal of Clinical Psychiatry, 71(8), 1040- 1046. doi: 10.4088/JCP.10cs06070blu Mulder, R. (2009). Is borderline personality disorder really a personality disorder? [Editorial]. Personality and Mental Health, 3(2), 85. doi: 10.1002/pmh.80 Mulder, R. T. (2010). Antidepressants and suicide: Population benefit vs. Individual risk [Editorial comment]. Acta Psychiatrica Scandinavica, 122(6), 442-443. doi: 10.1111/j.1600-0447.2010.01622.x Sellman, D. (2010). Ten things the alcohol industry won’t tell you about alcohol [Commentary]. Drug and Alcohol Review, 29(3), 301-303. doi: 10.1111/j.1465-3362.2009.00121.x Sellman, D. (2010). The 10 most important things known about addiction. Addiction, 105(1), 6-13. doi: 10.1111/j.1360- 0443.2009.02673.x Sellman, D., Adamson, S., Todd, F., & Deering, D. (2010). Science will uncover the mysteries of addiction in the end [Commentary]. Addiction, 105(1), 20-21. doi: 10.1111/j.1360-0443.2009.02867.x Sellman, D., Connor, J., Robinson, G., & Jackson, R. (2009). Alcohol cardio-protection has been talked up. New Zealand Medical Journal, 122(1303). Retrieved from http://www.nzma.org.nz/journal/archive.shtml Sellman, J. D., Connor, J. L., & Joyce, P. R. (2010). How to reduce alcohol-related problems in adolescents: What can parents do and what can the government do? [Editorial]. Australian and New Zealand Journal of Psychiatry, 44(9), 771-773. doi: 10.3109/00048674.2010.516425

Journal - Professional & Other Non-Research Articles Fergusson, D. M., Horwood, L. J., & Boden, J. M. (2009). [Authors’ reply to Abortion and mental health]. British Journal of Psychiatry, 195(1), 83-84. doi: 10.1192/bjp.195.1.83a Sellman, D. (2009). If alcohol was a new drug [Editorial]. New Zealand Medical Journal, 122(1303). Retrieved from http:// www.nzma.org.nz/journal/archive.shtml Smith, M., & Porter, R. (2009). Antipsychotics and risk of diabetes in schizophrenia [Correspondence]. British Journal of Psychiatry, 194(2), 186-187. doi: 10.1192/bjp.194.2.186a

Commissioned Report for External Body Adamson, S., Deering, D., Schroder, R., Townshend, P., & Ditchburn, M. (2009). National Telephone Survey of the Addiction Treatment Workforce. Commissioned by Matua Raki. Christchurch, New Zealand: National Addiction Centre, Department of Psychological Medicine, University of Otago, 51p. Retrieved from http://www.chmeds.ac.nz/departments/psychmed/ treatment/pdfs/telephonesurvey2008.pdf Deering, D., Robinson, G., Wheeler, A., Pulford, J., Frampton, C., Dunbar, L., & Black, S. (2009). Preliminary work towards validating a draft outcome measure for use in the alcohol and drug sector. Auckland, New Zealand: Te Pau o te Whakaaro Nui, 70p

Division of HEALTH SCIENCES 249 Working Paper; Discussion Paper; Technical Report Advisory Group on Conduct Problems, Blissett, W., Church, J., Fergusson, D., ..., Poulton, R., et al. (2009). Conduct problems: Best practice report. Wellington, New Zealand: Ministry of Social Development. (pp. 1-66).

Edited Journal Joyce, P. (Ed.). (2009). Australian and New Zealand Journal of Psychiatry (12 issues per year).

Awarded PhD Thesis Inder, M. L. (2009). ‘I actually don’t know who I am’: An exploration of the impact of bipolar disorder on the development of self and identity. Christchurch New Zealand: University of Otago, 267p.

University of Otago, Christchurch Department of Public Health and General Practice

Authored Book - Research Sheerin, I. (2009). Costs of injecting drug use: Benefits of treatment. Saarbrücken, Germany: VDM Verlag Dr. Müller Aktiengesellschaft, 460p.

Edited Book - Research Abel, G., Fitzgerald, L., Healy, C., & with Taylor, A. (Eds.). (2010). Taking the crime out of sex work: New Zealand sex workers’ fight for decriminalisation. Bristol, UK: Policy Press, 271p. Mintzes, B., Mangin, D., & Hayes, L. (Eds.). (2009). Understanding and responding to pharmaceutical promotion: A practical guide [Working draft for pilot field testing]. World Health Organization & Health Action International. Retrieved from http://www.haiweb.org/11062009/drug-promotion-manual-CAP-3-090610.pdf

Edited Book - Other Signal, L., Egan, R., & Cook, L. (Eds.). (2009). Reviews of health promotion practice in Aotearoa New Zealand 2007-2008. Auckland, New Zealand: Health Promotion Forum of New Zealand & Health Promotion and Policy Unit, University of Otago, 138p.

Chapter in Book - Research Abel, G., & Fitzgerald, L. (2010). Conclusion. In G. Abel, L. Fitzgerald & C. Healy with A. Taylor (Eds.), Taking the crime out of sex work: New Zealand sex workers’ fight for decriminalisation (pp. 259-264). Bristol, UK: Policy Press. Abel, G., & Fitzgerald, L. (2010). Decriminalisation and stigma. In G. Abel, L. Fitzgerald & C. Healy with A. Taylor (Eds.), Taking the crime out of sex work: New Zealand sex workers’ fight for decriminalisation (pp. 239-258). Bristol, UK: Policy Press. Abel, G., & Fitzgerald, L. (2010). Introduction. In G. Abel, L. Fitzgerald & C. Healy with A. Taylor (Eds.), Taking the crime out of sex work: New Zealand sex workers’ fight for decriminalisation (pp. 1-24). Bristol, UK: Policy Press. Abel, G., & Fitzgerald, L. (2010). Risk and risk management in sex work post-Prostitution Reform Act: A public health perspective. In G. Abel, L. Fitzgerald & C. Healy with A. Taylor (Eds.), Taking the crime out of sex work: New Zealand sex workers’ fight for decriminalisation (pp. 217-238). Bristol, UK: Policy Press. Abel, G., Fitzgerald, L., & Brunton, C. (2010). Christchurch School of Medicine study: Methodology and methods. In G. Abel, L. Fitzgerald & C. Healy with A. Taylor (Eds.), Taking the crime out of sex work: New Zealand sex workers’ fight for decriminalisation (pp. 159-172). Bristol, UK: Policy Press. Abel, G., Healy, C., Bennachie, C., & Reed, A. (2010). The Prostitution Reform Act. In G. Abel, L. Fitzgerald & C. Healy with A. Taylor (Eds.), Taking the crime out of sex work: New Zealand sex workers’ fight for decriminalisation (pp. 75-84). Bristol, UK: Policy Press. Brunton, C. (2010). Becoming inspectors of brothels: Public health authorities’ experience of implementing the Prostitution Reform Act. In G. Abel, L. Fitzgerald & C. Healy with A. Taylor (Eds.), Taking the crime out of sex work: New Zealand sex workers’ fight for decriminalisation (pp. 173-196). Bristol, UK: Policy Press. Fitzgerald, L., & Abel, G. (2010). The media and the Prostitution Reform Act. In G. Abel, L. Fitzgerald & C. Healy with A. Taylor (Eds.), Taking the crime out of sex work: New Zealand sex workers’ fight for decriminalisation (pp. 197-216). Bristol, UK: Policy Press. Mangin, D. (2009). Promotion, professional practice and patient trust. In B. Mintzes, D. Mangin, & L. Hayes (Eds.), Understanding and responding to pharmaceutical promotion: A practical guide [Working draft for pilot field testing] (pp. 163- 173). World Health Organization & Health Action International. Retrieved from http://www.haiweb.org/11062009/drug- promotion-manual-CAP-3-090610.pdf Mintzes, B., Toop, L., & Mangin, D. (2009). Promotion to consumers: Responding to patient requests for advertised medicines. In B. Mintzes, D. Mangin, & L. Hayes (Eds.), Understanding and responding to pharmaceutical promotion: A practical guide [Working draft for pilot field testing] (pp. 81-104). World Health Organization & Health Action International. Retrieved from http://www.haiweb.org/11062009/drug-promotion-manual-CAP-3-090610.pdf

250 RESEARCH REPORT 2009/2010 Journal - Research Article Abel, G. M., Fitzgerald, L. J., & Brunton, C. (2009). The impact of decriminalisation on the number of sex workers in New Zealand. Journal of Social Policy, 38(3), 515-531. doi: 10.1017/s0047279409003080 Aiello, A. E., Coulborn, R. M., Aragon, T. G., Baker, M. G., Burrus, B. B., Cowling, B., Duncan, A., ..., Priest, P., et al. (2010). Research findings from nonpharmaceutical intervention studies for pandemic influenza and current gaps in the research. American Journal of Infection Control, 38(4), 251-258. doi: 10.1016/j.ajic.2009.12.007 Badami, K. G., McQuilkan-Bickerstaffe, S., Wells, J. E., & Parata, M. (2009). Cytomegalovirus seroprevalence and ‘cytomegalovirus-safe’ seropositive blood donors. Epidemiology and Infection, 137(12), 1776-1780. doi: 10.1017/ s0950268809990094 Barnett, R., Pearce, J., Moon, G., Elliott, J., & Barnett, P. (2009). Assessing the effects of the introduction of the New Zealand Smokefree Environment Act 2003 on acute myocardial infarction hospital admissions in Christchurch, New Zealand. Australian and New Zealand Journal of Public Health, 33(6), 515-520. doi: 10.1111/j.1753-6405.2009.00446.x Blakely, T., Richardson, K., Young, J., Callister, P., & Didham, R. (2009). Does mortality vary between Pacific groups in New Zealand? Estimating Samoan, Cook Island Mäori, Tongan, and Niuean mortality rates using hierarchical Bayesian modelling. New Zealand Medical Journal, 122(1307). Retrieved from http://www.nzma.org.nz/journal/archive.shtml Blakely, T., Richardson, K., Young, J., Graham, P., Tobias, M., Callister, P., Didham, R., & Atkinson, J. (2009). Does mortality vary between Pacific groups? Estimating Samoan, Cook Island Mäori, Tongan and Niuean mortality rates using hierarchical Bayesian modelling. Official Statistics Research Series, 5. Retrieved from http://www.statisphere.govt.nz/ official-statistics-research.aspx Bradley, J., Bird, P., Monteath, P., & Wells, J. E. (2010). Improved speech discrimination after cochlear implantation in the Southern Cochlear Implant Adult Programme. New Zealand Medical Journal, 123(1321). Retrieved from http://www. nzma.org.nz/journal/archive.php Brown, A. F. T., Cullen, L., & Than, M. (2010). Future developments in chest pain diagnosis and management. Medical Clinics of North America, 94(2), 375-400. doi: 10.1016/j.mcna.2010.01.010 Cox, B., Richardson, A., Graham, P., Gislefoss, R. E., Jellum, E., & Rollag, H. (2010). Breast cancer, cytomegalovirus and Epstein-Barr virus: A nested case-control study. British Journal of Cancer, 102, 1665-1669. doi: 10.1038/sj.bjc.6605675 Cullen, L., Than, M., Brown, A. F. T., Richards, M., et al. (2010). Comprehensive standardized data definitions for acute coronary syndrome research in emergency departments in Australasia. Emergency Medicine Australasia, 22(1), 35-55. doi: 10.1111/j.1742-6723.2010.01256.x Cupples, J., & Thompson, L. (2010). Heterotextuality and digital foreplay: Cell phones and the culture of teenage romance. Feminist Media Studies, 10(1), 1-17. doi: 10.1080/14680770903457063 Dachs, G. U., Kano, M., Volkova, E., Morrin, H. R., Davey, V. C. L., Harris, G. C., Cheale, M., Frampton, C., Currie, M. J., Wells, J. E., & Robinson, B. A. (2010). A profile of prognostic and molecular factors in European and Mäori breast cancer patients. BMC Cancer, 10, 543. Retrieved from http://www.biomedcentral.com/1471-2407/10/543 Davidson, P. J., Sheerin, I. G., & Frampton, C. (2009). Renal stone disease in Christchurch, New Zealand: Part 1: Presentation and epidemiology. New Zealand Medical Journal, 122(1297). Retrieved from http://www.nzma.org.nz/ journal/122-1297/3659/ Davidson, P. J., Sheerin, I. G., & Frampton, C. (2009). Renal stone disease in Christchurch, New Zealand: Part 2: A community study on the burden of renal stone disease. New Zealand Medical Journal, 122(1297). Retrieved from http://www.nzma. org.nz/journal/122-1297/3660/ Degenhardt, L., Dierker, L., Chiu, W. T., ..., Wells, J. E., & Kessler, R. (2010). Evaluating the drug use ‘Gateway’ theory using cross-national data: Consistency and associations of the order of initiation of drug use among participants in the WHO World Mental Health Surveys. Drug and Alcohol Dependence, 108, 84-97. doi: 10.1016/j.drugalcdep.2009.12.001 de Graaf, R., Radovanovic, M., van Laar, M., ..., Wells, J. E., & Anthony, J. C. (2010). Early cannabis use and estimated risk of later onset of depression spells: Epidemiologic evidence from the population-based World Health Organization World Mental Health Survey Initiative. American Journal of Epidemiology, 172(2), 149-159. doi: 10.1093/aje/kwq096 Dew, K., Stubbe, M., MacDonald, L., Dowell, A., & Plumridge, E. (2010). The (non) use of prioritisation protocols by surgeons. Sociology of Health and Illness, 32(4), 545-562. doi: 10.1111/j.1467-9566.2009.01229.x Doughty, C., & Tse, S. (2010). Can consumer-led mental health services be equally effective? An integrative review of CLMH services in high-income countries. Community Mental Health Journal, Advance Online Publication. doi: 10.1007/s10597- 010-9321-5 Dowson, C. A., Kuijer, R. G., Town, I. G., & Mulder, R. T. (2010). Impact of panic disorder upon self-management educational goals in chronic obstructive pulmonary disease? Chronic Respiratory Disease, 7(2), 83-90. doi: 10.1177/1479972310365363 Duncan, A. R., Priest, P. C., Jennings, L. C., Brunton, C. R., & Baker, M. G. (2009). Screening for influenza infection in international airline travelers. American Journal of Public Health, 99(Suppl. 2), S360-S362. doi: 10.2105/AJPH.2008.158071 Garfinkel, D., & Mangin, D. (2010). Feasibility study of a systematic approach for discontinuation of multiple medications in older adults: Addressing polypharmacy. Archives of Internal Medicine, 170(18), 1648-1654. doi: 10.1001/ archinternmed.2010.355 Graham, P., Rodnyanskiy, L., & Henley, L. (2009). Confidentialising microdata using multiple imputation: Development and evaluation of a non-parametric hierarchical Bayesian imputation model for numerical data. Official Statistics Research Series, 5. Retrieved from http://www.statisphere.govt.nz/official-statistics-research.aspx Graham, P., Young, J., & Penny, R. (2009). Multiply imputed synthetic data: Evaluation of hierarchical Bayesian imputation models. Journal of Official Statistics, 25(2), 245-268.

Division of HEALTH SCIENCES 251 Healy, D., Mangin, D., & Mintzes, B. (2010). The ethics of randomized placebo controlled trials of antidepressants with pregnant women. International Journal of Risk and Safety in Medicine, 22(1), 7-16. doi: 10.3233/JRS-2010-0487 Hider, P. N., Griffin, G., Walker, M., & Coughlan, E. P. (2009). The information-seeking behavior of clinical staff in a large health care organization. Journal of the Medical Library Association, 97(1), 47-50. doi: 10.3163/1536-5050.97.1.009 Huggan, P. J., Wells, J. E., Browne, M., Richardson, A., Murdoch, D. R., & Chambers, S. T. (2010). Population-based epidemiology of Staphylococcus aureus bloodstream infection in Canterbury, New Zealand. Internal Medicine Journal, 40(2), 117-125. doi: 10.1111/j.1445-5994.2009.01910.x James, M. L., Lehman, M., Hider, P. N., Jeffery, M., Hickey, B. E., & Francis, D. P. (2010). Fraction size in radiation treatment for breast conservation in early breast cancer. Cochrane Database of Systematic Reviews, 11, CD003860. doi: 10.1002/14651858.CD003860.pub3 Kokaua, J., Schaaf, D., Wells, J. E., & Foliaki, S. A. (2009). Twelve-month prevalence, severity, and treatment contact of mental disorders in New Zealand born and migrant Pacific participants in Te Rau Hinengaro: The New Zealand Mental Health Survey. Pacific Health Dialog, 15(1), 9-17. Kokaua, J., & Wells, J. E. (2009). Twelve-month prevalences of mental disorders and treatment contact among Cook Islanders resident in New Zealand. Pacific Health Dialog, 15(1), 79-88. Lee, S., Tsang, A., Kessler, R. C., ..., Wells, J. E., et al. (2010). Rapid-cycling bipolar disorder: Cross-national community study. British Journal of Psychiatry, 196, 217-225. doi: 10.1192/bjp.bp.109.067843 Lienert, A. R., Davidson, P. J., & Wells, J. E. (2009). The outcomes of transrectal ultrasound guided biopsy of the prostate in a New Zealand population. New Zealand Medical Journal, 122(1288). Retrieved from http://www.nzma.org.nz/ journal/122-1288/3439/ Mackenzie, K. A., Wells, J. E., Lynn, K. L., Simcock, J. W., Robinson, B. A., Roake, J. A., & Currie, M. J. (2010). First and subsequent nonmelanoma skin cancers: Incidence and predictors in a population of New Zealand renal transplant recipients. Nephrology Dialysis Transplantation, 25, 300-306. doi: 10.1093/ndt/gfp482 Malcolm, L. (2010). Towards a reliable and accurate ethnicity database at district and national levels: Progress in Canterbury. New Zealand Medical Journal, 123(1314). Retrieved from http://www.nzma.org.nz/journal/123-1314/4108/content.pdf Malcolm, L., & Barnett, R. (2009). Utilisation of inpatient cardiology services including by Mäori: A study of hospital discharges for patients enrolled with Partnership Health practices for the 2 years ending June 2007. New Zealand Medical Journal, 122(1304). Retrieved from http://www.nzma.org.nz/journal/ Mangin, D. (2010). All people over 75 years with a five-year CVD risk of ³15% should be treated with statins unless specifically contraindicated: No. Journal of Primary Health Care, 2(4), 333-335. McEwing, R. L., Anderson, N. G., Meates, J. B. A., Allen, R. B., Phillipson, G. T. M., & Wells, J. E. (2009). Sonographic appearances of the endometrium after termination of pregnancy in asymptomatic versus symptomatic women. Journal of Ultrasound in Medicine, 28(5), 579-586. McKenzie, J. E., Priest, P., Audas, R., Poore, M. R., Brunton, C. R., & Reeves, L. M. (2010). Hand sanitisers for reducing illness absences in primary school children in New Zealand: A cluster randomised controlled trial study protocol. Trials, 11, 7. doi: 10.1186/1745-6215-11-7 Oakley Browne, M. A., Wells, J. E., Scott, K. M., McGee, M. A., & New Zealand Mental Health Survey Research Team (2010). The Kessler Psychological Distress Scale in Te Rau Hinengaro: The New Zealand Mental Health Survey. Australian and New Zealand Journal of Psychiatry, 44(4), 314-322. doi: 10.3109/00048670903279820 Richardson, K., Blakely, T., Young, J., Graham, P., & Tobias, M. (2009). Do ethnic and socio-economic inequalities in mortality vary by region in New Zealand? An application of hierarchical Bayesian modelling. Social Science and Medicine, 69(8), 1252-1260. doi: 10.1016/j.socscimed.2009.07.036 Rumball-Smith, J., & Hider, P. (2009). The validity of readmission rate as a marker of the quality of hospital care, and a recommendation for its definition. New Zealand Medical Journal, 122(1289). Retrieved from http://nzma.org.nz/ journal/122-1289/3462/ Rumball-Smith, J., Hider, P., & Graham, P. (2009). The readmission rate as an indicator of the quality of elective surgical inpatient care for the elderly in New Zealand. New Zealand Medical Journal, 122(1289). Retrieved from http://www.nzma. org.nz/journal/122-1289/3461/ Rumball-Smith, J. M. L. (2009). Not in my hospital? Ethnic disparities in quality of hospital care in New Zealand: A narrative review of the evidence. New Zealand Medical Journal, 122(1297). Retrieved from http://www.nzma.org.nz/ journal/122-1297/3662/ Sabanli, M., Balasingham, A., Bailey, W., Eglinton, T., Hider, P., & Frizelle, F. A. (2010). Computed tomographic colonography in the diagnosis of colorectal cancer. British Journal of Surgery, 97(8), 1291-1294. doi: 10.1002/bjs.7098 Scott, K. M., Oakley Browne, M. A., & Wells, J. E. (2010). Prevalence, impairment and severity of 12-month DSM-IV major depressive episodes in Te Rau Hinengaro: New Zealand Mental Health Survey 2003/4. Australian and New Zealand Journal of Psychiatry, 44(8), 750-758. doi: 10.3109/00048671003781780 Scott, K. M., Wells, J. E., Angermeyer, M., Brugha, T. S., Bromet, E., Demyttenaere, K., de Girolamo, G., et al. (2010). Gender and the relationship between marital status and first onset of mood, anxiety and substance use disorders. Psychological Medicine, 40, 1495-1505. doi: 10.1017/S0033291709991942 Sheerin, I. (2009). Hospital expenditure on treating complications of diabetes and the potential for deferring complications in Canterbury, New Zealand. New Zealand Medical Journal, 122(1288). Retrieved from http://www.nzma.org.nz/ journal/122-1288/3429/

252 RESEARCH REPORT 2009/2010 Souter, M. A., Allison, R. S., Clarkson, J. H., Cowan, I. A., Coates, M. H., & Wells, J. E. (2009). Sensitivity and specificity of computed tomography for detection of extranodal spread from metastatic head and neck squamous cell carcinoma. Journal of Laryngology & Otology, 123, 778-782. doi: 10.1017/S0022215109004332 Starfield, B., & Mangin, D. (2010). An international perspective on the basis for payment for performance. Quality in Primary Care, 18. Storr, C. L., Cheng, H., Alonso, J., ..., Wells, J. E., et al. (2010). Smoking estimates from around the world: Data from the first 17 participating countries in the World Mental Health Survey Consortium. Tobacco Control, 19, 65-74. doi: 10.1136/ tc.2009.032474 Thompson, L. E., Barnett, J. R., & Pearce, J. R. (2009). Scared straight? Fear-appeal anti-smoking campaigns, risk, self-efficacy and addiction. Health, Risk and Society, 11(2), 181-196. doi: 10.1080/13698570902784281 Thompson, L., Pearce, J., & Barnett, R. (2009). Nomadic identities and socio-spatial competence: Making sense of post- smoking selves. Social & Cultural Geography, 10(5), 565-581. doi: 10.1080/14649360902974431 Volkova, E., Willis, J. A., Wells, J. E., Robinson, B. A., Dachs, G. U., & Currie, M. J. (2010). Association of angiopoietin-2, C-reactive protein and markers of obesity and insulin resistance with survival outcome in colorectal cancer. British Journal of Cancer, Advance Online Publication. doi: 10.1038/sj.bjc.6606005 Wells, J. E., Degenhardt, L., Bohnert, K. M., Anthony, J. C., Scott, K. M., & New Zealand Mental Health Survey Research Team (2009). Geographical clustering of cannabis use: Results from the New Zealand Mental Health Survey 2003-2004. Drug and Alcohol Dependence, 99(1-3), 309-316. doi: 10.1016/j.drugalcdep.2008.09.002 Wells, J. E., Kingi, T. K., & McGee, M. (2009). Self-reported proficiency in Mäori language among those of Mäori descent in New Zealand. Kötuitui: New Zealand Journal of Social Sciences Online, 4, 179-190. Wells, J. E., McGee, M. A., Baxter, J., Agnew, F., Kokaua, J., & New Zealand Mental Health Survey Research Team (2009). Onset and lifetime use of drugs in New Zealand: Results from Te Rau Hinengaro: The New Zealand Mental Health Survey 2003- 2004. Drug and Alcohol Review, 28(2), 166-174. doi: 10.1111/j.1465-3362.2008.00043.x Wells, J. E., McGee, M. A., & Beautrais, A. L. (2010). Multiple aspects of sexual orientation: Prevalence and sociodemographic correlates in a New Zealand National Survey. Archives of Sexual Behavior, Advance Online Publication. doi: 10.1007/ s10508-010-9636-x Wells, J. E., McGee, M. A., Scott, K. M., & Oakley-Browne, M. A. (2010). Bipolar disorder with frequent mood episodes in the New Zealand Mental Health Survey. Journal of Affective Disorders, 126(1-2), 65-74. doi: 10.1016/j.jad.2010.02.136 Williams, D., Begg, A., Burgess, K., Hider, M., Jennings, L., ..., Pithie, A., Schroeder, P., & Werno, A. (2010). Influenza H1N1 2009 in Canterbury: A case study in pandemic response co-ordination. Journal of Primary Health Care, 2(4), 323-329. Young, J., Graham, P., & Penny, R. (2009). Using Bayesian networks to create synthetic data. Journal of Official Statistics, 25(4), 549-567.

Journal - Research Other Adamson, S. J., & Wells, J. E. (2009). Hazardous drinking: Not just an issue for the minority of drinkers [Editorial]. New Zealand Medical Journal, 122(1306). Retrieved from http://www.nzma.org.nz/journal/archive.shtml Currie, E., Daley, V., & Richardson, A. (2010). Increased use of nicotine replacement therapy at Christchurch Hospital [Letter]. New Zealand Medical Journal, 123(1318). Retrieved from http://www.nzma.org.nz/journal/123-1318/4225/content.pdf Dew, K., Stubbe, M., MacDonald, L., Dowell, A., & Plumridge, E. (2010). How useful are clinical priority assessment tools? [Research Gems]. Journal of Primary Health Care, 2(2), 174-175. Healy, D., & Mangin, D. (2009). The once and future psychiatry [Commentary]. Academic Medicine, 84(4), 418-420. Hudson, B. (2009). Tyneside to New Zealand [Essay]. Journal of Primary Health Care, 1(2), 154-155. Hudson, B. (2010). Vitamin-B12-Mangel. Praxis, 99(23), 1435-1436. doi: 10.1024/1661-8157/a000315 Mangin, D. (2010). Urinary tract infection in primary care [Editorial]. BMJ, 340, c657. doi: 10.1136/bmj.c657 Mintzes, B., & Mangin, D. (2009). Direct-to-consumer advertising of prescription medicines: A counter argument. Future Medicinal Chemistry, 1(9), 1555-1560. doi: 10.4155/fmc.09.136 Toop, L. (2009). A polypill is the solution to the pharmacological management of cardiovascular risk: No. Journal of Primary Health Care, 1(3), 234-236. Toop, L., & Mangin (Richards), D. (2009). [Commentary to A dipstick clinical prediction rule modestly improved diagnostic precision in women with suspected urinary tract infection]. Evidence-Based Medicine, 14(5), 155. doi: 10.1136/ebm.14.5.155 Wells, J. E. (2009). Comparisons of the 2007 National Survey of Mental Health and Wellbeing and the 2003-2004 New Zealand Mental Health Survey [Editorial]. Australian and New Zealand Journal of Psychiatry, 43(7), 585-590.

Journal - Professional & Other Non-Research Articles Cottler, L. B., Regier, D. A., Helzer, J. E., Earls, F. J., Wells, J. E., Sartorius, N., Rutter, M., Bebbington, P., & Zorumski, C. F. (2010). A tribute to Lee Nelken Robins: From colleagues and friends [Obituary]. Social Psychiatry and Psychiatric Epidemiology, 45(7), 681-693. doi: 10.1007/s00127-010-0243-x Healy, D., Mangin, D., & Mintzes, B. (2010). Risky business [Letter to the editor]. Hastings Hudson, B. (2010). Information v promotion [Letter]. BMJ, 341, c6650. doi: 10.1136/bmj.c6650 Hudson, B. (2010). Vitamin B-12 deficiency. BMJ, 340, c2305. doi: 10.1136/bmj.c2305 Mangin, D. (2009). Women should give informed consent before starting SSRIs [Letter to the editor]. BMJ, 339, b4292. doi: 10.1136/bmj.b4292

Division of HEALTH SCIENCES 253 Richardson, A. (2010). Response to the Missing Manuscript editorial [Letter]. New Zealand Medical Journal, 123(1320). Retrieved from http://www.nzma.org.nz/journal/123-1320/4279/content.pdf Sheerin, I. (2009). Food suppliers and changes in the law for 2009 and beyond. Health in a Shell, 73, 9-10.

University of Otago, Christchurch Department of Radiology

Journal - Research Article Ahn, M. I., Gleeson, T. G., Chan, I. H., McWilliams, A. M., MacDonald, S. L., Lam, S., Atkar-Khattra, S., & Mayo, J. R. (2010). Perifissural nodules seen at CT screening for lung cancer. Radiology, 254(3), 949-956. doi: 10.1148/radiol.09090031 Anderson, N. G., Butler, A. P., Scott, N. J. A., Cook, N. J., Butzer, J. S., Schleich, N., et al. (2010). Spectroscopic (multi-energy) CT distinguishes iodine and barium contrast material in MICE. European Radiology, 20, 2126-2134. doi: 10.1007/s00330- 010-1768-9 Anderson, N. G., Fischer, J., Leighton, D., Hector-Taylor, J., & McEwing, R. L. (2010). Management in children of mild postnatal renal dilatation but without vesicoureteral reflux. Pediatric Nephrology, 25(3), 477-843. doi: 10.1007/s00467-009- 1348-x Bergin, M., Bird, P., Cowan, I., & Pearson, J. F. (2010). Exploring the critical distance and position relationships between the eustachian tube and the internal carotid artery. Otology & Neurotology, Advance Online Publication. doi: 10.1097/ MAO.0b013e3181f6c880 Buckenham, T., McKewen, M., Laing, A., Roake, J., Lewis, D., & Gordon, M. K. (2009). Cyanoacrylate embolization of endoleaks after abdominal aortic aneurysm repair. ANZ Journal of Surgery, 79(11), 841-843. doi: 10.1111/j.1445- 2197.2009.05113.x Butler, A. P. H., Butzer, J., Schleich, N., Cook, N. J., Anderson, N. G., Scott, N., de Ruiter, N., Grasset, R., Tlustos, L., & Butler, P. H. (2010). Processing of spectral X-ray data with principal components analysis. Nuclear Instruments and Methods in Physics Research A, Advance Online Publication. doi: 10.1016/j.nima.2010.06.149 Chan, W., Campbell, T., MacDonald, S., & Crozier, I. (2010). Christchurch experience of pulmonary embolism with and without thrombolysis. New Zealand Medical Journal, 123(1324). Retrieved from http://www.nzma.org.nz/ journal/123-1324/4381/content.pdf Dalrymple-Alford, J. C., MacAskill, M. R., Nakas, C. T., Livingston, L., Graham, C., Crucian, G. P., Melzer, T. R., Kirwan, J., Keenan, R., Wells, S., Porter, R. J., Watts, R., & Anderson, T. J. (2010). The MoCA: Well-suited screen for cognitive impairment in Parkinson disease. Neurology, 75(19), 1717-1725. doi: 10.1212/WNL.0b013e3181fc29c9 Day, C. P., & Buckenham, T. M. (2009). Endovascular repair of the thoracic aorta: Predictors of 30-day mortality in patients on the New Zealand Thoracic Aortic Stent Database (NZ TAS). European Journal of Vascular and Endovascular Surgery, 37(2), 160-165. doi: 10.1016/j.ejvs.2008.09.020 Ferguson, C. D., Clancy, P., Bourke, B., ..., Buckenham, T., et al. (2010). Association of statin prescription with small abdominal aortic aneurysm progression. American Heart Journal, 159(2), 307-313. doi: 10.1016/j.ahj.2009.11.016 Hornibrook, J., Coates, M., Goh, T., & Bird, P. (2010). MRI imaging of the inner ear for Meniere’s disease. New Zealand Medical Journal, 123(1321). Retrieved from http://www.nzma.org.nz/journal/123-1321/4310/content.pdf Kang, A. C. L., Gooding, A. J., Coates, M. H., Goh, T. D., Armour, P., & Rietveld, J. (2010). Computed tomography assessment of hip joints in asymptomatic individuals in relation to femoroacetabular impingement. The American Journal of Sports Medicine, 38(6), 1160-1165. doi: 10.1177/0363546509358320 McEwing, R. L., Anderson, N. G., Meates, J. B. A., Allen, R. B., Phillipson, G. T. M., & Wells, J. E. (2009). Sonographic appearances of the endometrium after termination of pregnancy in asymptomatic versus symptomatic women. Journal of Ultrasound in Medicine, 28(5), 579-586. Miller, A., Rudland, J., Hurrell, M., & Ali, A. (2009). Rad-Path: Integrated anatomical pathology and radiology undergraduate tutorials. Pathology, 41(5), 460-466. doi: 10.1080/00313020903049286 Sabanli, M., Balasingham, A., Bailey, W., Eglinton, T., Hider, P., & Frizelle, F. A. (2010). Computed tomographic colonography in the diagnosis of colorectal cancer. British Journal of Surgery, 97(8), 1291-1294. doi: 10.1002/bjs.7098 Souter, M. A., Allison, R. S., Clarkson, J. H., Cowan, I. A., Coates, M. H., & Wells, J. E. (2009). Sensitivity and specificity of computed tomography for detection of extranodal spread from metastatic head and neck squamous cell carcinoma. Journal of Laryngology & Otology, 123, 778-782. doi: 10.1017/S0022215109004332 Westwood, D. A., Fernando, C., & Connor, S. J. (2010). Internal-external percutaneous transhepatic biliary drainage for malignant biliary obstruction: A retrospective analysis. Journal of Medical Imaging and Radiation Oncology, 54(2), 108-110. doi: 10.1111/j.1754-9485.2010.02147. Young, J., Quinn, S., Hurrell, M., & Taylor, B. (2009). Clinically isolated acute transverse myelitis: Prognostic features and incidence. Multiple Sclerosis, 15(11), 1295-1302. doi: 10.1177/1352458509345906

Journal - Research Other Butler, A. (2009). The increasing role of bioengineering and medical physics in the practice of medicine [Editorial]. New Zealand Medical Journal, 122(1297). Retrieved from http://www.nzma.org.nz/journal/122-1297/3658/ Macdonald, C. A., Jardine, D. L., Hurrell, M. A., & Pithie, A. D. (2009). The worm that turned [Case report]. Transactions of the Royal Society of Tropical Medicine and Hygiene, 103(10), 1065-1067. doi: 10.1016/j.trstmh.2009.05.007

254 RESEARCH REPORT 2009/2010 Slaven, A. (2010). A patient journey and the ACC [Letter]. New Zealand Medical Journal, 123(1327). Retrieved from http:// www.nzma.org.nz/journal/123-1327/4488/content.pdf

Journal - Professional & Other Non-Research Articles Buckenham, T. M. (2009). Contrast-induced nephropathy: Does it really exist? [Editorial]. New Zealand Medical Journal, 122(1299). Buckenham, T. M. (2009). Where has carotid stenting gone? [Editorial]. New Zealand Medical Journal, 122(1304). Retrieved from http://www.nzma.org.nz/journal/archive.shtml Chan, W. Y. W., McClean, D. R., Elliott, J. M., & MacDonald, S. (2009). CT coronary angiography to guide intervention for acute myocardial ischaemia in a patient with an anomalous single coronary ostium. Heart, Lung and Circulation, 18(6), 407-409. doi: 10.1016/j.hlc.2008.04.006 Memon, S., Laing, A. D., & Frye, J. N. R. (2010). Traumatic splenic injury managed with arterial embolisation in a patient with idiopathic thrombocytopenic pupura [Letter to the editor]. CardioVascular and Interventional Radiology, 33(4), 877-879. doi: 10.1007/s00270-009-9735-z Rumball-Smith, A., & MacDonald, S. (2010). Development and utilisation of a real-time display of logged in radiology information system users. Journal of Digital Imaging, Advance Online Publication. doi: 10.1007/s10278-010-9310-9

University of Otago, Christchurch Department of Surgery

Chapter in Book - Research Auldist, A. W., & Blakelock, R. (2009). Pulmonary hydatid disease. In D. H. Parikh, D. C. G. Crabbe, A. W. Auldist, & S. S Rothenberg (Eds.), Pediatric thoracic surgery (pp. 161-168). London: Springer. doi: 10.1007/b136543 Beasley, S. (2009). Congenital malformations. In D. H. Parikh, D. C. G. Crabbe, A. W. Auldist, & S. S Rothenberg (Eds.), Pediatric thoracic surgery (pp. 281-312). London: Springer. doi: 10.1007/b136543

Journal - Research Article Allardyce, R. A., Bagshaw, P. F., Frampton, C. M., Frizelle, F. A., Hewett, P. J., Rieger, N. A., Smith, J. S., Solomon, M. J., Stevenson, A. R. L., & Australasian Laparoscopic Colon Cancer Study Group (2010). Australasian Laparoscopic Colon Cancer Study shows that elderly patients may benefit from lower postoperative complication rates following laparoscopic versus open resection. British Journal of Surgery, 97, 86-91. doi: 10.1002/bjs.6785 Bagshaw, P. F., Allardyce, R. A., Bagshaw, S. N., Stokes, B. W., Shaw, C. S., Proffit, L. J., Nicholls, M. G., Begg, E. J., & Frampton, C. M. (2010). Patients “falling through the cracks”. The Canterbury Charity Hospital: Initial progress report. New Zealand Medical Journal, 123(1320). Retrieved from http://www.nzma.org.nz/journal/archive.php Bergin, M., Bird, P., Cowan, I., & Pearson, J. F. (2010). Exploring the critical distance and position relationships between the eustachian tube and the internal carotid artery. Otology & Neurotology, Advance Online Publication. doi: 10.1097/ MAO.0b013e3181f6c880 Bergin, M., Murray, D., & Bird, P. (2010). An unusual case of cotton wool use to improve hearing. Journal of Laryngology and Otology, 124(8), 922-924. doi: 10.1017/s0022215109992453 Bird, P., Botting, A., Milburn, J., Murray, D., & Heslop, N. (2010). An audit of referrals to the Southern Cochlear Implant Paediatric Programme. New Zealand Medical Journal, 123(1313). Retrieved from http://www.nzma.org.nz/ journal/123-1313/ Bradley, J., Bird, P., Monteath, P., & Wells, J. E. (2010). Improved speech discrimination after cochlear implantation in the Southern Cochlear Implant Adult Programme. New Zealand Medical Journal, 123(1321). Retrieved from http://www. nzma.org.nz/journal/archive.php Brodie, T., & Lewis, D. R. (2010). A survey of patient views on receiving vascular outpatient letters. European Journal of Vascular and Endovascular Surgery, 39, 5-10. doi: 10.1016/j.ejvs.2009.09.019 Buckenham, T., McKewen, M., Laing, A., Roake, J., Lewis, D., & Gordon, M. K. (2009). Cyanoacrylate embolization of endoleaks after abdominal aortic aneurysm repair. ANZ Journal of Surgery, 79(11), 841-843. doi: 10.1111/j.1445- 2197.2009.05113.x Ching, T., Roake, J. A., & Lewis, D. R. (2010). Net-based information on varicose vein treatments: A tangled web. New Zealand Medical Journal, 123(1323). Retrieved from http://www.nzma.org.nz/journal/123-1323/4355/content.pdf Edirimanne, S., Roake, J. A., & Lewis, D. R. (2010). Delays in discharge of vascular surgical patients: A prospective audit. ANZ Journal of Surgery, 80(6), 443-446. doi: 10.1111/j.1445-2197.2009.05130.x Eglinton, T., Luck, A., Bartholomeusz, D., Varghese, R., & Lawrence, M. (2010). Positron-emission tomography/computed tomography (PET/CT) in the initial staging of primary rectal cancer. Colorectal Disease, 12(7), 667-673. doi: 10.1111/j.1463-1318.2009.01851.x Eglinton, T., Reilly, M., Chang, C., Barclay, M., Frizelle, F., & Gearry, R. (2010). Ileal disease is associated with surgery for perianal disease in a population-based Crohn’s disease cohort. British Journal of Surgery, 97(7), 1103-1109. doi: 10.1002/ bjs.7031 Eglinton, T. W., & Gearry, R. B. (2010). Clinical factors predicting disease course in Crohn’s disease. Expert Review of Clinical Immunology, 6(1), 41-45. doi: 10.1586/eci.09.76

Division of HEALTH SCIENCES 255 Ellis, E., Ballance, K., Lunt, H., & Lewis, D. (2010). Diabetes outpatient care before and after admission for diabetic foot complications. Journal of Wound Care, 19(4), 150-152. Endre, Z. H., Pickering, J. W., Storer, M. K., Hu, W-P., Moorhead, K. T., Allardyce, R., McGregor, D. O., & Scotter, J. M. (2010). Breath ammonia and trimethylamine allow real-time monitoring of haemodialysis efficacy. Physiological Measurement, 32(1), 115-130. doi: 10.1088/0967-3334/32/1/008 Epton, M. J., Ledingham, K., Dummer, J., Hu, W-P., Rhodes, B., Senthilmohan, S. T., Scotter, J. M., Allardyce, R., Cook, J., & Swanney, M. P. (2009). Interference of chlorofluorocarbon (CFC)-containing inhalers with measurements of volatile compounds using selected ion flow tube mass spectrometry. Rapid Communications in Mass Spectrometry, 23(3), 443-447. doi: 10.1002/rcm.3875 Frizelle, F. A., Ing, A., Gearry, R. B., Whitehead, M., Faragher, I. G., & Dobbs, B. (2009). Immunomodulation does not alter histology in resected Crohn’s disease. Techniques in Coloproctology, 13(4), 295-300. doi: 10.1007/s10151-009-0538-7 Herbison, G. P., & Arnold, E. P. (2009). Sacral neuromodulation with implanted devices for urinary storage and voiding dysfunction in adults. Cochrane Database of Systematic Reviews, 2, CD004202. doi: 10.1002/14651858.CD004202.pub2 Hornibrook, J., Coates, M., Goh, T., & Bird, P. (2010). MRI imaging of the inner ear for Meniere’s disease. New Zealand Medical Journal, 123(1321). Retrieved from http://www.nzma.org.nz/journal/123-1321/4310/content.pdf Keenan, J. I., Beaugie, C. R., Jasmann, B., Potter, H. C., Collett, J. A., & Frizelle, F. A. (2010). Helicobacter species in the human colon. Colorectal Disease, 12(1), 48-53. doi: 10.1111/j.1463-1318.2008.01672.x Keenan, J. I., Salm, N., Hampton, M. B., & Wallace, A. J. (2010). Individual and combined effects of foods on Helicobacter pylori growth. Phytotherapy Research, 24(8), 1229-1233. doi: 10.1002/ptr.3167 Kennedy, R., Lee, A., & Frizelle, F. A. (2010). Influence of general health and degree of surgical insult on long-term survival. British Journal of Surgery, 97, 782-788. doi: 10.1002/bjs.6960 Khashram, M., Huggan, P., Ikram, R., Chambers, S., Roake, J. A., & Lewis, D. R. (2009). Effect of TNP on the microbiology of venous leg ulcers: A pilot study. Journal of Wound Care, 18(4), 164-167. Khashram, M., Roake, J. A., & Lewis, D. R. (2009). The effect of vacuum-assisted closure on the tissue oxygenation of venous ulcers: A pilot study. Wounds, 21(9), 249-253. Khashram, M., Roake, J. A., & Lewis, D. R. (2010). Patient flow to carotid endarterectomy: Hastening the patient journey. ANZ Journal of Surgery, 80(6), 406-410. doi: 10.1111/j.1445-2197.2010.05308.x Lewis, D. R. (2009). Who do you want to treat your varicose veins? New Zealand Medical Journal, 122(1295). Retrieved from http://www.nzma.org.nz/journal/122-1295/3609/ Mackenzie, K. A., Wells, J. E., Lynn, K. L., Simcock, J. W., Robinson, B. A., Roake, J. A., & Currie, M. J. (2010). First and subsequent nonmelanoma skin cancers: Incidence and predictors in a population of New Zealand renal transplant recipients. Nephrology Dialysis Transplantation, 25, 300-306. doi: 10.1093/ndt/gfp482 Mittal, A., Göke, F., Flint, R., Loveday, B. P. T., Thompson, N., Delahunt, B., et al. (2010). The redox status of experimental hemorrhagic shock as measured by cyclic voltammetry. Shock, 33(5), 460-466. doi: 10.1097/SHK.0b013e3181c0ea12 Moesbergen, T., Law, A., Roake, J., & Lewis, D. R. (2009). Diastasis recti and abdominal aortic aneurysm. Vascular, 17(6), 325- 329. doi: 10.2310/6670.2009.00047 Munday, J. S., Keenan, J. I., Beaugie, C. R., & Sugiarto, H. (2009). Ovine small intestinal adenocarcinomas are not associated with infection by herpesviruses, Helicobacter species or Mycobacterium avium subspecies paratuberculosis. Journal of Comparative Pathology, 140(2-3), 177-181. doi: 10.1016/j.jcpa.2008.11.005 Paddison, J. S., Booth, R. J., Cameron, L. D., Robinson, E., Frizelle, F. A., & Hill, A. G. (2009). Fatigue after colorectal surgery and its relationship to patient expectations. Journal of Surgical Research, 151(1), 145-152. doi: 10.1016/j.jss.2008.01.030 Parker, H., Chitcholtan, K., Hampton, M. B., & Keenan, J. I. (2010). Uptake of Helicobacter pylori outer membrane vesicles by gastric epithelial cells. Infection and Immunity, Advance Online Publication. doi: 10.1128/IAI.00299-10 Sabanli, M., Balasingham, A., Bailey, W., Eglinton, T., Hider, P., & Frizelle, F. A. (2010). Computed tomographic colonography in the diagnosis of colorectal cancer. British Journal of Surgery, 97(8), 1291-1294. doi: 10.1002/bjs.7098 Simcock, J. W., Penington, A. J., Morrison, W. A., Thompson, E. W., & Mitchell, G. M. (2009). Endothelial precursor cells home to a vascularized tissue engineering chamber by application of the angiogenic chemokine CXCL12. Tissue Engineering Part A, 15(3), 655-664. Simpson, J. C., Turnbull, B. L., Ardagh, M., & Richardson, S. (2009). Child home injury prevention: Understanding the context of unintentional injuries to preschool children. International Journal of Injury Control and Safety Promotion, 16(3), 159- 167. doi: 10.1080/17457300903135636 Souter, M. A., Allison, R. S., Clarkson, J. H., Cowan, I. A., Coates, M. H., & Wells, J. E. (2009). Sensitivity and specificity of computed tomography for detection of extranodal spread from metastatic head and neck squamous cell carcinoma. Journal of Laryngology & Otology, 123, 778-782. doi: 10.1017/S0022215109004332 Southwell, K. E., Bird, P. A., & Murray, D. P. (2010). Cochlear implantation in children with CHARGE syndrome. Cochlear Implants International, 11(3), 170-183. doi: 10.1002/cii.423 Suh, J., Roake, J. A., & Lewis, D. R. (2009). Quality of clinical notes for vascular surgery admissions: A CRABEL score review. ANZ Journal of Surgery, 79(7-8), 539-543. doi: 10.1111/j.1445-2197.2009.04986.x Sutherland, A. D., Faragher, I. G., & Frizelle, F. A. (2009). Intradermal injection of methylene blue for the treatment of refractory pruritus ani. Colorectal Disease, 11(3), 282-287. doi: 10.1111/j.1463-1318.2008.01587.x Than, M. P., Helm, J., Calder, K., Ardagh, M. W., Smith, M., Flaws, D. F., & Beckert, L. (2009). Comparison of high specificity with standard versions of a quantative latex D-dimer test in the assessment of community pulmonary embolism HaemosIL D-dimer HS and Pulmonary Embolism. Thrombosis Research, 124, 230-235. doi: 10.1016/j. thromres.2008.10.018

256 RESEARCH REPORT 2009/2010 Tovaranonte, P. P., Beasley, S. W., Maoate, K., Blakelock, R., & Skinner, A. (2010). Trends in the use of minimally invasive surgery in children. New Zealand Medical Journal, 123(1313). Retrieved from http://www.nzma.org.nz/journal/archive. shtml Yang, A. S., & Bird, P. (2009). Intracranial metastatic melanoma presenting with bilateral hearing loss. Otology & Neurotology, 30(2), 243-244. doi: 10.1097/MAO.0b013e31816c7c88 Yoshida, A., Maoate, K., Blakelock, R. T., Robertson, S., & Beasley, S. (2010). Long-term functional outcomes in children with Currarino syndrome. Pediatric Surgery International, 26, 677-681. doi: 10.1007/s00383-010-2615-4 Zhang, M., Moore, G., Jensen, B. P., Begg, E. J., & Bird, P. A. (2010). Determination of dexamethasone and dexamethasone sodium phosphate in human plasma and cochlear perilymph by liquid chromatography/tandem mass spectrometry. Journal of Chromatography B, Advance Online Publication. doi: 10.1016/j.jchromb.2010.11.003

Journal - Research Other Ardagh, M. (2010). How to achieve New Zealand’s shorter stays in emergency departments health target [Viewpoint]. New Zealand Medical Journal, 123(1316). Retrieved from http://www.nzma.org.nz/journal/123-1316/4152/content.pdf Beasley, S. W. (2009). Driveway accidents in New Zealand [Editorial]. New Zelaand Medical Journal, 122(1298). Retrieved from http://www.nzma.org.nz/journal/122-1298/ Frizelle, F. A. (2010). The missing manuscript [Editorial]. New Zealand Medical Journal, 123(1319). Retrieved from http:// www.nzma.org.nz/journal/123-1319/4252/content.pdf Frizelle, F. A. (2010). The New Zealand Medical Journal, Thomson Reuters ISI, and the impact factor [Editorial]. New Zealand Medical Journal, 123(1323). Retrieved from http://www.nzma.org.nz/journal/123-1323/4363/content.pdf Ganly, P., Downing, J., Stiven, P., Frizelle, F., & Badami, K. (2010). Clinical and serological diagnoses of a patient with vancomycin-induced thrombocytopenia [Letter to the editor]. Transfusion Medicine, Advance Online Publication. doi: 10.1111/j.1365-3148.2010.01052.x Hewett, P. J., & Frizelle, F. (2010). Does laparoscopic colectomy have a higher intraoperative complication rate than open colectomy? [Reply to letter to the editor]. Annals of Surgery, 251(3), 578. doi: 10.1097/SLA.0b013e3181d0d3fb International Committee of Medical Journal Editors (ICMJE), & including Frizelle, F. A. (2010). Towards more uniform conflict disclosures: The updated ICMJE conflict of interest reporting form [Editorial]. New Zealand Medical Journal, 123(1318). Retrieved from http://www.nzma.org.nz/journal/123-1318/4206/content.pdf Jina, H., Mercer, P., Gordon, M., Singh, H., & Whitehead, M. (2010). Angiomatosis: A case report. New Zealand Medical Journal, 123(1319). Retrieved from http://www.nzma.org.nz/journal/123-1319/4231/content.pdf Khashram, M., & Lewis, D. R. (2009). Kinky carotids: Left retropharyngeal cervical internal carotid artery [Medical image]. New Zealand Medical Journal, 122(1292). Retrieved from http://www.nzma.org.nz/journal/archive.php Mackenzie, K. A., Simcock, J. W., Lainchbury, J. G., Currie, M. J., & Lynn, K. L. (2009). Myocardial metastasis of cutaneous squamous cell carcinoma in a renal transplant recipient [Case report]. Transplantation Proceedings, 41(10), 4414-4415. doi: 10.1016/j.transproceed.2009.09.056 Mwandila, M., Waller, H., Stott, V., & Mercer, P. (2010). A case of a testosterone-secreting oncocytic adrenocortical carcinoma. New Zealand Medical Journal, 123(1325). Retrieved from http://www.nzma.org.nz/journal/123-1325/4418/content.pdf Robinson, L., McKellar, M., Fitzharris, B., & Elder, M. (2009). Topical mitomycin C for the local treatment of a primary diffuse large B-cell lymphoma of the palpebral conjunctiva [Letter to the editor]. Clinical and Experimental Ophthalmology, 37(9), 891-892. doi: 10.1111/j.1442-9071.2009.02173.x Sakowska, M. M., Bagshaw, P., & Eglinton, T. (2010). An unusual case of large bowel obstruction. New Zealand Medical Journal, 123(1308). Retrieved from http://www.nzma.org.nz/journal/123-1308/3954/content.pdf Schumacher, H. H. A., Chia, H. L., & Simcock, J. W. (2010). Ipsilateral skin grafts for lower limb melanoma reconstruction are safe [Viewpoint]. Plastic and Reconstructive Surgery, 125(2), 89e-91e. doi: 10.1097/PRS.0b013e3181c72812 Simcock, J. W. (2010). Managing the skin cancer surge [Editorial]. New Zealand Medical Journal, 123(1325). Retrieved from http://www.nzma.org.nz/journal/123-1325/4411/content.pdf

Journal - Professional & Other Non-Research Articles Frizelle, F. A. (2010). Cartwright Inquiry correspondence in the NZMJ: Enough is enough [Editorial]. New Zealand Medical Journal, 123(1327). Retrieved from http://www.nzma.org.nz/journal/123-1327/4483/content.pdf Morton, J. (2010). [Review of the book Enhancing patient care: A practical guide to improving quality and safety in hospitals]. New Zealand Medical Journal, 123(1321). Retrieved from http://www.nzma.org.nz/journal/123-1321/4322/content.pdf

Division of HEALTH SCIENCES 257 University of Otago, Christchurch Centre for Postgraduate Nursing Studies

Journal - Research Article Bennett, J. A., Brown, P., Cameron, L., Whitehead, L. C., Porter, D., & McPherson, K. M. (2009). Changes in employment and household income during the 24 months following a cancer diagnosis. Supportive Care in Cancer, 17(8), 1057-1064. doi: 10.1007/s00520-008-0540-z Bennett, J. A., Cameron, L. D., Brown, P. M., Whitehead, L. C., Porter, D., Ottaway-Parkes, T., & Robinson, E. (2010). Time since diagnosis as a predictor of symptoms, depression, cognition, social concerns, perceived benefits, and overall health in cancer survivors. Oncology Nursing Forum, 37(3), 331-338. doi: 10.1188/10.ONF.331-338 Bennett, J. A., Cameron, L. D., Whitehead, L. C., & Porter, D. (2009). Differences between older and younger cancer survivors in seeking cancer information and using complementary/alternative medicine. Journal of General Internal Medicine, 24(10), 1089-1094. doi: 10.1007/s11606-009-0979-8 Burrell, B. A. (2009). The replacement of the replacement in menopause: Hormone therapy, controversies, truth and risk. Nursing Inquiry, 16(3), 212-222. doi: 10.1111/j.1440-1800.2009.00456.x Burrell, B., Valledor, V., Crowe, M., & Whitehead, L. (2010). Negotiating competing discourses: The decision to take menopausal hormone therapy following surgical menopause. Women and Health, 50(6), 527-543. doi: 10.1080/03630242.2010.516699 Crowe, M., Whitehead, L., Gagan, M. J., Baxter, D., & Panckhurst, A. (2010). Self-management and chronic low back pain: A qualitative study. Journal of Advanced Nursing, 66(7), 1478-1486. doi: 10.1111/j.1365-2648.2010.05316.x Crowe, M., Whitehead, L., Gagan, M. J., Baxter, G. D., Panckhurst, A., & Valledor, V. (2010). Listening to the body and talking to myself: The impact of chronic lower back pain: A qualitative study. International Journal of Nursing Studies, 47, 586-592. doi: 10.1016/j.ijnurstu.2009.09.012 Crowe, M., Whitehead, L., Wilson, L., Carlyle, D., O’Brien, A., Inder, M., & Joyce, P. (2010). Disorder-specific psychosocial interventions for bipolar disorder-A systematic review of the evidence for mental health nursing practice. International Journal of Nursing Studies, 47, 896-908. doi: 10.1016/j.ijnurstu.2010.02.012 Dawson, S. I. (2009). Glucose tolerance in pregnancy and the long-term risk of cardiovascular disease. Diabetes Research and Clinical Practice, 85(1), 14-19. doi: 10.1016/j.diabres.2009.04.007 Dunn, J. A., Hay-Smith, E. J. C., Whitehead, L. C., Keeling, S., & Rothwell, A. G. (2010). Upper limb reconstructive surgery uptake for persons with tetraplegia in New Zealand: A retrospective case review 2001-2005. Spinal Cord, Advance Online Publication. doi: 10.1038/sc.2010.15 Foster, M., Whitehead, L., & Maybee, P. (2010). Parents’ and health professionals’ perceptions of family centred care for children in hospital, in developed and developing countries: A review of the literature. International Journal of Nursing Studies, 47, 1184-1193. doi: 10.1016/j.ijnurstu.2010.05.005 Muir, L. A., George, P. M., Laurie, A. D., Reid, N., & Whitehead, L. (2010). Preventing cardiovascular disease: A review of the effectiveness of identifying the people with familial hypercholesterolaemia in New Zealand. New Zealand Medical Journal, 123(1326). Retrieved from http://www.nzma.org.nz/journal/123-1326/4439/ Richardson, S., Williams, T., Finlay, A., & Farrell, M. (2009). Senior nurses’ perceptions of cultural safety in an acute clinical practice area. Nursing Praxis in New Zealand, 25(3), 27-36. Ritchie, L. (2009). Wearing two hats: Interviewing older people as a nurse researcher. Medical Sociology Online, 4(1), 14-24. Taylor, B. V., Pearson, J. F., Clarke, G., Mason, D. F., Abernethy, D. A., Willoughby, E., & Sabel, C. (2010). MS prevalence in New Zealand, an ethnically and latitudinally diverse country. Multiple Sclerosis, 16(12), 1422-1431. doi: 10.1177/1352458510379614 The Australia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene), including Clarke, G., McCallum, R., Merriman, M., Merriman, T., & Mason, D. (2009). Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. Nature Genetics, 41(7), 824-828. doi: 10.1038/ng.396 Whitehead, L. (2009). The measurement of fatigue in chronic illness: A systematic review of unidimensional and multidimensional fatigue measures. Journal of Pain and Symptom Management, 37(1), 107-128. doi: 10.1016/j. jpainsymman.2007.08.019 Wilkinson, A., & Whitehead, L. (2009). Evolution of the concept of self-care and implications for nurses: A literature review. International Journal of Nursing Studies, 46(8), 1143-1147. doi: 10.1016/j.ijnurstu.2008.12.011

Journal - Professional & Other Non-Research Articles Gagan, M. J. (2009). The SOAP format enhances communication: The SOAP format provides a clear and concise way of documenting patient information. Kai Tiaki Nursing New Zealand, 15(5), 15. Whitehead, L. (2009). [Review of the book Australia and New Zealand community as partner: Theory and practice in nursing]. Journal of Primary Health Care, 1(2), 163.

258 RESEARCH REPORT 2009/2010 SCHOOL OF PHARMACY

Authored Book - Research Heydon, S. (2009). Modern medicine and international aid: Khunde Hospital, Nepal, 1966-1998. Hyderabad, India: Orient BlackSwan, 380p.

Chapter in Book - Research Lovelock, K., & Leopold, T. (2010). The political economy of temporary migration: Seasonal workers, tourists and sustaining New Zealand’s labour force. In J. Mosedale (Ed.), Political economy and tourism: A critical perspective . Routledge.

Journal - Research Article Aaltonen, J., & Rades, T. (2009). Towards physico-relevant dissolution testing: The importance of solid-state analysis in dissolution [Commentary]. Dissolution Technologies, 16(2), 47-54. Aaltonen, K., Ragupathy, R., Tordoff, J., Reith, D., & Norris, P. (2010). The impact of pharmaceutical cost containment policies on the range of medicines available and subsidized in Finland and New Zealand. Value in Health, 13(1), 148-156. doi: 10.1111/j.1524-4733.2009.00598.x Allesø, M., Chieng, N., Rehder, S., Rantanen, J., Rades, T., & Aaltonen, J. (2009). Enhanced dissolution rate and synchronized release of drugs in binary systems through formulation: Amorphous naproxen-cimetidine mixtures prepared by mechanical activation. Journal of Controlled Release, 136(1), 45-53. doi: 10.1016/j.jconrel.2009.01.027 Al-Salami, H., Butt, G., Tucker, I., Fawcett, P. J., Golocorbin-Kon, S., Mikov, I., & Mikov, M. (2009). Gliclazide reduces MKC intestinal transport in healthy but not diabetic rats. European Journal of Drug Metabolism and Pharmacokinetics, 34(1), 43-50. Al-Sallami, H. S., Barras, M. A., Green, B., & Duffull, S. B. (2010). Routine plasma anti-Xa monitoring is required for low- molecular-weight heparins. Clinical Pharmacokinetics, 49(9), 567-571. doi: 10.2165/11532960-000000000-00000 Al-Sallami, H. S., Kumar, V. V. P., Landersdorfer, C. B., Bulitta, J. B., & Duffull, S. B. (2009). The time course of drug effects. Pharmaceutical Statistics, 8, 176-185. doi: 10.1002/pst.393 Baeumer, B., Chatterjee, L., Hinow, P., Rades, T., Radunskaya, A., & Tucker, I. (2009). Predicting the drug release kinetics of matrix tablets. Discrete and Continuous Dynamical Systems: Series B, 12(2), 261-277. doi: 10.3934/dcdsb.2009.12.261 Baker, J. F., Devitt, B. M., Kiely, P. D., Green, J., Mulhall, K. J., Synnott, K. A., & Poynton, A. R. (2010). Prevalence of Internet use amongst an elective spinal surgery outpatient population. European Spine Journal, 19(10), 1776-1779. doi: 10.1007/ s00586-010-1377-y Barras, M. A., Duffull, S. B., Atherton, J. J., & Green, B. (2009). Modelling the occurrence and severity of enoxaparin- induced bleeding and bruising events. British Journal of Clinical Pharmacology, 68(5), 700-711. doi: 10.1111/j.1365- 2125.2009.03518.x Barras, M. A., Duffull, S. B., Atherton, J. J., & Green, B. (2010). Individualized dosing of enoxaparin for subjects with renal impairment is superior to conventional dosing at achieving therapeutic concentrations. Therapeutic Drug Monitoring, 32(4), 482-488. doi: 10.1097/FTD.0b013e3181e64846 Boyd, B. J., Dong, Y-D., & Rades, T. (2009). Nonlamellar liquid crystalline nanostructured particles: Advances in materials and structure determination. Journal of Liposome Research, 19(1), 12-28. doi: 10.1080/08982100802691983 Braund, R., & Abbott, J. H. (2010). Recommending NSAIDs and paracetamol: A survey of New Zealand physiotherapists’ knowledge and behaviours. Physiotherapy Research International, Advance Online Publication. doi: 10.1002/pri.472 Braund, R., Furlan, H. M., George, K., Havell, M. M. A., Murphy, J. L., & West, M. K. (2010). Interventions performed by New Zealand community pharmacists while dispensing prescription medications. Pharmacy World and Science, 32, 22-25. doi: 10.1007/s11096-009-9343-7 Braund, R., Gn, G., & Matthews, R. (2009). Investigating unused medications in New Zealand. Pharmacy World and Science, 31(6), 664-669. doi: 10.1007/s11096-009-9325-9 Braund, R., Hook, S. M., Greenhill, N., & Medlicott, N. J. (2009). Distribution of fibroblast growth factor-2 (FGF-2) within model excisional wounds following topical application. Journal of Pharmacy and Pharmacology, 61(2), 193-200. doi: 10.1211/jpp/61.02.0008 Braund, R., Peake, B. M., & Shieffelbien, L. (2009). Disposal practices for unused medications in New Zealand. Environment International, 35(6), 952-955. Brown, K. K., Blaikie, F. H., Smith, R. A. J., Tyndall, J. D. A., Lue, H., Bernhagen, J., Winterbourn, C. C., & Hampton, M. B. (2009). Direct modification of the proinflammatory cytokine macrophage migration inhibitory factor by dietary isothiocyanates. Journal of Biological Chemistry, 284(47), 32425-32433. doi: 10.1074/jbc.M109.047092 Bulitta, J. B., Duffull, S. B., Landersdorfer, C. B., Kinzig, M., Holzgrabe, U., Stephan, U., Drusano, G. L., & Sörgel, F. (2009). Comparison of the pharmacokinetics and pharmacodynamic profile of carumonam in cystic fibrosis patients and healthy volunteers. Diagnostic Microbiology and Infectious Disease, 65(2), 130-141. doi: 10.1016/j.diagmicrobio.2009.06.018 Bushby, S. K., Anderson, R. J., & Braund, R. (2010). New Zealand parent’s perceptions of the use and safety of over the counter liquid analgesics. Pharmacy Practice, 8(4), 238-242. Capstick, S., Norris, P., Sopoaga, F., & Tobata, W. (2009). Relationships between health and culture in Polynesia: A review. Social Science and Medicine, 68(7), 1341-1348. doi: 10.1016/j.socscimed.2009.01.002

Division of HEALTH SCIENCES 259 Cavalcante, G. I. T., Capistrano Jr, V. L. M., Cavalcante, F. S. D., Vasconcelos, S. M. M., Macêdo, D. S., Sousa, F. C. F., Woods, D. J., & Fonteles, M. M. F. (2010). Implications of efavirenz for neuropsychiatry: A review. International Journal of Neuroscience, 120(12), 739-745. doi: 10.3109/00207454.2010.520541 Chatterjee, L., Rades, T., & Tucker, I. G. (2010). Mechanical properties of excipients do not affect polymer matrix formation. International Journal of Pharmaceutics, 384(1/2), 87-92. doi: 10.1016/j.ijpharm.2009.09.047 Chen, G., Fawcett, J. P., Mikov, M., & Tucker, I. G. (2009). Monoketocholate can decrease transcellular permeation of methotrexate across Caco-2 cell monolayers and reduce its intestinal absorption in rat. Journal of Pharmacy and Pharmacology, 61(7), 953-959. doi: 10.1211/jpp/61.07.0016 Chen, G., Fawcett, J. P., Mikov, M., & Tucker, I. G. (2009). Simultaneous determination of methotrexate and its polyglutamate metabolites in Caco-2 cells by liquid chromatography-tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 50(2), 262-266. doi: 10.1016/j.jpba.2009.04.025 Chieng, N., Aaltonen, J., Saville, D., & Rades, T. (2009). Physical characterization and stability of amorphous indomethacin and ranitidine hydrochloride binary systems prepared by mechanical activation. European Journal of Pharmaceutics and Biopharmaceutics, 71(1), 47-54. doi: 10.1016/j.ejpb.2008.06.022 Chieng, N., Hubert, M., Saville, D., Rades, T., & Aaltonen, J. (2009). Formation kinetics and stability of carbamazepine- nicotinamide cocrystals prepared by mechanical activation. Crystal Growth & Design, 9(5), 2377-2386. doi: 10.1021/ cg801253f Chieng, N., Rehder, S., Saville, D., Rades, T., & Aaltonen, J. (2009). Quantitative solid-state analysis of three solid forms of ranitidine hydrochloride in ternary mixtures using Raman spectroscopy and X-ray powder diffraction. Journal of Pharmaceutical and Biomedical Analysis, 49(1), 18-25. doi: 10.1016/j.jpba.2008.09.054 Daines, A. M., Greatrex, B. W., Hayman, C. M., Hook, S. M., McBurney, W. T., Rades, T., Rendle, P. M., & Sims, I. M. (2009). Mannosylated saponins based on oleanolic and glycyrrhizic acids. Towards synthetic colloidal antigen delivery systems. Bioorganic and Medicinal Chemistry, 17(14), 5207-5218. doi: 10.1016/j.bmc.2009.05.043 Dameh, M., Green, J., & Norris, P. (2010). Over-the-counter sales of antibiotics from community pharmacies in Abu Dhabi. Pharmacy World and Science, Advance Online Publication. doi: 10.1007/s11096-010-9418-5 Denman, N. G., McGree, J. M., Eccleston, J. A., & Duffull, S. B. (2010). Design of experiments for bivariate binary responses modelled by Copula functions. Computational Statistics & Data Analysis, Advance Online Publication. doi: 10.1016/j. csda.2010.07.025 Duffull, S. B., Wright, D. F. B., & Winter, H. R. (2010). Interpreting population pharmacokinetic-pharmacodynamic analyses: A clinical viewpoint. British Journal of Clinical Pharmacology, Advance Online Publication. doi: 10.1111/j.1365- 2125.2010.03891.x Eriksson, E. J., Sullivan, K. P. H., Zetterholm, E., Czigler, P. E., Green, J., Skagerstrand, Å., & van Doom, J. (2010). Detection of imitated voices: Who are reliable earwitnesses? International Journal of Speech Language and the Law, 17(1), 25-44. doi: 10.1558/ijsll.v17i1.25 Ferderber, K., Hook, S., & Rades, T. (2009). Phosphatidyl choline-based colloidal systems for dermal and transdermal drug delivery. Journal of Liposome Research, 19(4), 267-277. doi: 10.3109/08982100902814006 Foo, L-K., & Duffull, S. (2010). Methods of robust design of nonlinear models with an application to pharmacokinetics. Journal of Biopharmaceutical Statistics, 20(4), 886-902. doi: 10.1080/10543401003618918 Fry, B. G., Roelants, K., Champagne, D. E., ..., Tyndall, J. D. A., et al. (2009). The toxicogenomic multiverse: Convergent recruitment of proteins into animal venoms. Annual Review of Genomics and Human Genetics, 10, 483-511. doi: 10.1146/ annurev.genom.9.081307.164356 Furlong, J. M. (2010). An evaluation of plasma homocysteine in the assessment of vitamin B12 status of pasture-fed sheep. New Zealand Veterinary Journal, 58(1), 11-16. Gauld, R., Goldfinch, S., & Horsburgh, S. (2010). Do they want it? Do they use it? The ‘demand-side’ of e-government in Australia and New Zealand. Government Information Quarterly, 27(2), 177-186. doi: 10.1016/j.giq.2009.12.002 Glaessl, B., Siepmann, F., Tucker, I., Rades, T., & Siepmann, J. (2010). Deeper insight into the drug release mechanisms in Eudragit RL-based delivery systems. International Journal of Pharmaceutics, 389, 139-146. doi: 10.1016/j. ijpharm.2010.01.031 Glaessl, B., Siepmann, F., Tucker, I., Rades, T., & Siepmann, J. (2010). Mathematical modeling of drug release from Eudragit RS-based delivery systems. Journal of Drug Delivery Science and Technology, 20(2), 127-133. Glaessl, B., Siepmann, F., Tucker, I., Siepmann, J., & Rades, T. (2009). Characterisation of quaternary polymethacrylate films containing tartaric acid, metoprolol free base or metoprolol tartrate. European Journal of Pharmaceutics and Biopharmaceutics, 73, 36-372. doi: 10.1016/j.ejpb.2009.07.010 Golocorbin-Kon, S., Mikov, M., Arafat, M., Lepojevic, Z., Mikov, I., Sahman-Zaimovic, M., & Tomic, Z. (2009). Cefotaxime pharmacokinetics after oral application in the form of 3 alpha,7 alpha-dihydroxy-12-keto-5 beta-cholanate microvesicles in rat. European Journal of Drug Metabolism and Pharmacokinetics, 34(1), 31-36. Gordon, S., Teichmann, E., Young, K., Finnie, K., Rades, T., & Hook, S. (2010). In vitro and in vivo investigation of thermosensitive chitosan hydrogels containing silica nanoparticles for vaccine delivery. European Journal of Pharmaceutical Sciences, Advance Online Publication. doi: 10.1016/j.ejps.2010.07.004 Graeser, K. A., Patterson, J. E., & Rades, T. (2009). Applying thermodynamic and kinetic parameters to predict the physical stability of two differently prepared amorphous forms of simvastatin. Current Drug Delivery, 6(4), 374-382. doi: 10.2174/156720109789000492

260 RESEARCH REPORT 2009/2010 Graeser, K. A., Patterson, J. E., Zeitler, J. A., Gordon, K. C., & Rades, T. (2009). Correlating thermodynamic and kinetic parameters with amorphous stability. European Journal of Pharmaceutical Sciences, 37(3-4), 492-498. doi: 10.1016/j. ejps.2009.04.005 Graf, A., McDowell, A., & Rades, T. (2009). Poly(alkycyanoacrylate) nanoparticles for enhanced delivery of therapeutics: Is there real potential? Expert Opinion on Drug Delivery, 6(4), 371-387. doi: 10.1517/17425240902870413 Graf, A., Rades, T., & Hook, S. M. (2009). Oral insulin delivery using nanoparticles based on microemulsions with different structure-types: Optimisation and in vivo evaluation. European Journal of Pharmaceutical Sciences, 37(1), 53-61. doi: 10.1016/j.ejps.2008.12.017 Greatrex, B. W., Brodie, S. J., Furneaux, R. H., Hook, S. M., McBurney, W. T., Painter, G. F., Rades, T., & Rendle, P. M. (2009). The synthesis and immune stimulating action of mannose-capped lysine-based dendrimers. Tetrahedron, 65(15), 2939- 2950. doi: 10.1016/j.tet.2009.02.018 Gupta, N., Zhang, H., & Liu, P. (2009). Behavioral and neurochemical effects of acute putrescine depletion by difluoromethylornithine in rats. Neuroscience, 161(3), 691-706. doi: 10.1016/j.nueroscience.2009.03.075 Han, J., Jiang, S., Cui, X., Sun, Y., Li, G., Zhang, J., Fawcett, J. P., & Gu, J. (2009). Quantitation of the tacrine analogue octahydroaminoacridine in human plasma by liquid chromatography-tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 50(2), 171-174. doi: 10.1016/j.jpba.2009.03.022 Heinz, A., Gordon, K. C., McGoverin, C. M., Rades, T., & Strachan, C. J. (2009). Understanding the solid-state forms of fenofibrate: A spectroscopic and computational study. European Journal of Pharmaceutics and Biopharmaceutics, 71(1), 100-108. doi: 10.1016/j.ejpb.2008.05.030 Heinz, A., Strachan, C. J., Gordon, K. C., & Rades, T. (2009). Analysis of solid-state transformations of pharmaceutical compounds using vibrational spectroscopy. Journal of Pharmacy and Pharmacology, 61(8), 971-988. doi: 10.1211/ jpp/61.08.0001 Heydon, S. (2010). Celebrating and reflecting on the centenary of tropical medicine in Australia, 1910-2010. Annals of the ACTM: An International Journal of Tropical & Travel Medicine, 11(1), 5-7. Ho, L., Cuppok, Y., Muschert, S., Gordon, K. C., Pepper, M., Shen, Y., Siepmann, F., Siepmann, J., Taday, P. F., & Rades, T. (2009). Effects of film coating thickness and drug layer uniformity on in vitro drug release from sustained-release coated pellets: A case study using terahertz pulsed imaging. International Journal of Pharmaceutics, 382(1-2), 151-159. doi: 10.1016/j.ijpharm.2009.08.025 Ho, L., Müller, R., Gordon, K. C., Kleinebudde, P., Pepper, M., Rades, T., Shen, Y., Taday, P. F., & Zeitler, J. A. (2009). Monitoring the film coating unit operation and predicting drug dissolution using terahertz pulsed imaging. Journal of Pharmaceutical Sciences, 98(12), 4866-4876. doi: 10.1002/jps.21766 Ho, L., Müller, R., Gordon, K. C., Kleinebudde, P., Pepper, M., Rades, T., Shen, Y., Taday, P. F., & Zeitler, J. A. (2009). Terahertz pulsed imaging as an analytical tool for sustained-release tablet film coating. European Journal of Pharmaceutics and Biopharmaceutics, 71(1), 117-123. doi: 10.1016/j.ejpb.2008.06.023 Ho, L., Müller, R., Krüger, C., Gordon, K. C., Kleinebudde, P., Pepper, M., Rades, T., Shen, Y., Taday, P. F., & Zeitler, J. A. (2010). Investigating dissolution performance critical areas on coated tablets: A case study using terahertz pulsed imaging. Journal of Pharmaceutical Sciences, 99(1), 392-402. doi: 10.1002/jps.21845 Horsburgh, S., Norris, P., Becket, G., Crampton, P., Arroll, B., Cumming, J. M., Herbison, P., & Sides, G. (2010). The Equity in Prescription Medicines Use study: Using community pharmacy databases to study medicines utilisation. Journal of Biomedical Informatics, Advance Online Publication. doi: 10.1016/j.jbi.2010.08.004 Isbister, G. K., Balit, C. R., Macleod, D., & Duffull, S. B. (2010). Amisulpride overdose is frequently associated with QT prolongation and Torsades de pointes. Journal of Clinical Psychopharmacology, 30(4), 391-395. doi: 10.1097/ JCP.0b013e3181e5c14c Isbister, G. K., & Duffull, S. B. (2009). Quetiapine overdose: Predicting intubation, duration of ventilation, cardiac monitoring and the effect of activated charcoal. International Clinical Psychopharmacology, 24(4), 174-180. doi: 10.1097/ YIC.0b013e32832bb078 Isbister, G. K., Duffull, S. B., Brown, S. G. A., & ASP Investigators (2009). Failure of antivenom to improve recovery in Australian snakebite coagulopathy. QJM: An International Journal of Medicine, 102(8), 563-568. doi: 10.1093/qjmed/ hcp081 Jain, R., Wu, Z., & Tucker, I. G. (2009). A stability-indicating HPLC assay with diode array detection for the determination of a benzylpenicillin prodrug in aqueous solutions. Journal of Pharmaceutical and Biomedical Analysis, 50(5), 841-846. doi: 10.1016/j.jpba.2009.06.046 James, T. H., Helms, M. L., & Braund, R. (2009). Analysis of medications returned to community pharmacies. Annals of Pharmacotherapy, 43(10), 1631-1635. doi: 10.1345/aph.1M209 Jatrana, S., Crampton, P., & Norris, P. (2010). Ethnic differences in access to prescription medication because of cost in New Zealand. Journal of Epidemiology and Community Health, Advance Online Publication. doi: 10.1136/jech.2009.099101 Jeffs, A. R., Glover, A. C., Slobbe, L. J., Wang, L., He, S., Hazlett, J. A., Awasthi, A., Woolley, A. G., Marshall, E. S., Joseph, W. R., Print, C. G., Baguley, B. C., & Eccles, M. R. (2009). A gene expression signature of invasive potential in metastatic melanoma cells. PLoS ONE, 4(12), e8461. doi: 10.1371/journal.pone.0008461 Jørgensen, A. C., Strachan, C. J., Pöllänen, K. H., Koradia, V., Tian, F., & Rantanen, J. (2009). An insight into water of crystallization during processing using vibrational spectroscopy. Journal of Pharmaceutical Sciences, 98(11), 3903-3932. doi: 10.1002/jps.21735

Division of HEALTH SCIENCES 261 Jurna, M., Windbergs, M., Strachan, C. J., Hartsuiker, L., Otto, C., Kleinebudde, P., Herek, J. L., & Offerhaus, H. L. (2009). Coherent anti-stokes raman scattering microscopy to monitor drug dissolution in different oral pharmaceutical tablets. Journal of Innovative Optical Health Sciences, 2(1), 37-43. Kafka, A. P., Kleffmann, T., Rades, T., & McDowell, A. (2009). Histidine residues in the peptide d-Lys6-GnRH: Potential for copolymerization in polymeric nanoparticles. Molecular Pharmaceutics, 6(5), 1483-1491. doi: 10.1021/mp900043e Kafka, A. P., Kleffmann, T., Rades, T., & McDowell, A. (2010). Characterization of peptide polymer interactions in poly(alkylcyanoacrylate) nanoparticles: A mass spectrometric approach. Current Drug Delivery, 7(3), 208-215. Kafka, A. P., Kleffmann, T., Rades, T., & McDowell, A. (2010). The application of MALDI TOF MS in biopharmaceutical research. International Journal of Pharmaceutics, Advance Online Publication. doi: 10.1016/j.ijpharm.2010.12.010 Kafka, A. P., Rades, T., & McDowell, A. (2010). Rapid and specific high-performance liquid chromatography for the in vitro quantification of d-Lys6-GnRH in a microemulsion-type formulation in the presence of peptide oxidation products. Biomedical Chromatography, 24(2), 132-139. doi: 10.1002/bmc.1261 Khunawattanakul, W., Puttipipatkhachorn, S., Rades, T., & Pongjanyakul, T. (2010). Chitosan-magnesium aluminum silicate nanocomposite films: Physicochemical characterization and drug permeability. International Journal of Pharmaceutics, 393, 219-229. doi: 10.1016/j.ijpharm.2010.04.007 Korell, J., Coulter, C. V., & Duffull, S. B. (2010). A statistical model for red blood cell survival. Journal of Theoretical Biology, 268, 39-49. doi: 10.1016/j.jtbi.2010.10.010 Krittaphol, W., McDowell, A., Thomson, C. D., Mikov, M., & Fawcett, J. P. (2010). Biotransformation of l-selenomethionine and selenite in rat gut contents. Biological Trace Element Research, Advance Online Publication. doi: 10.1007/s12011-010- 8653-x Krittaphol, W., McDowell, A., Thomson, C. D., Tucker, I. G., Fawcett, J. P., & Mikov, M. (2009). An improved HPLC method for the investigation of &LSCAP;-selenomethionine metabolism in rat gut contents. Biomedical Chromatography, 23, 1169-1174. doi: 10.1002/bmc.1239 Kumar, V. V. P., Oscarsson, S., Friberg, L. E., Isbister, G. K., Hackett, L. P., & Duffull, S. B. (2009). The effect of decontamination procedures on the pharmacokinetics of venlafaxine in overdose. Clinical Pharmacology and Therapeutics, 86(4), 403-410. doi: 10.1038/clpt.2009.114 Kunac, D. L., Kennedy, J., Austin, N., & Reith, D. (2009). Incidence, preventability, and impact of adverse drug events (ADEs) and potential ADEs in hospitalized children in New Zealand: A prospective observational cohort study. Pediatric Drugs, 11(2), 153-160. doi: 10.2165/00148581-200911020-00005 Lalic, M., Cvejić, J., Popovic, J., Bozic, K., Golocorbin-Kon, S., Al-Salami, H., & Mikov, M. (2009). Lamotrigine and valproate pharmacokinetics interactions in epileptic patients. European Journal of Drug Metabolism and Pharmacokinetics, 34(2), 93-99. Lamping, E., Ranchod, A., Nakamura, K., Tyndall, J. D. A., Niimi, K., Holmes, A. R., Niimi, M., & Cannon, R. D. (2009). Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. Antimicrobial Agents and Chemotherapy, 53(2), 354-369. doi: 10.1128/AAC.01095-08 Lee, E., Braund, R., & Tordoff, J. (2009). Examining the first year of Medicines Use Review services provided by pharmacists in New Zealand: 2008. New Zealand Medical Journal, 122(1293). Retrieved from http://www.nzma.org.nz/ journal/122-1293/3560 Lee, H. J., Orlovich, D. A., Tagg, J. R., & Fawcett, J. P. (2009). Detection and specific enumeration of multi-strain probiotics in the lumen contents and mucus layers of the rat intestine after oral administration. Probiotics and Antimicrobial Proteins, 1(2), 113-120. doi: 10.1007/s12602-009-9019-6 Lee, H. J., Waller, R. D., Stebbings, S., Highton, J., Orlovich, D. A., Schmierer, D., & Fawcett, J. P. (2010). The effects of an orally administered probiotic on sulfasalazine metabolism in individuals with rheumatoid arthritis: A preliminary study. International Journal of Rheumatic Diseases, 13(1), 48-54. doi: 10.1111/j.1756-185X.2009.01449.x Li, H., Zhang, C., Wang, J., Jiang, Y., Fawcett, J. P., & Gu, J. (2010). Simultaneous quantitation of paracetamol, caffeine, pseudoephedrine, chlorpheniramine and cloperastine in human plasma by liquid chromatography-tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 51(3), 716-722. doi: 10.1016/j.jpba.2009.10.009 Liu, P., Jing, Y., Collie, N. D., Chary, S., & Zhang, H. (2009). Memory-related changes in l-citrulline and agmatine in the rat brain. Hippocampus, 19(7), 597-602. doi: 10.1002/hipo.20561 Liu, P., Jing, Y., & Zhang, H. (2009). Age-related changes in arginine and its metabolites in memory-associated brain structures. Neuroscience, 164(2), 611-628. doi: 10.1016/j.neuroscience.2009.08.029 Liu, P., Zhang, H., Devaraj, R., Ganesalingam, G., & Smith, P. F. (2010). A multivariate analysis of the effects of aging on glutamate, GABA and arginine metabolites in the rat vestibular nucleus. Hearing Research, 269(1-2), 122-133. doi: 10.1016/j.heares.2010.06.019 Li, Y., Zhang, H., Fawcett, J. P., & Tucker, I. G. (2010). Effect of cyclosporin A on the pharmacokinetics of mitoquinone

(MitoQ10), a mitochondria-targeted antioxidant, in rat. Asian Journal of Pharmaceutical Sciences, 5(3), 106-113. Loke, S-K., Tordoff, J., Winikoff, M., McDonald, J., Vlugter, P., & Duffull, S. (2010). SimPharm: How pharmacy students made meaning of a clinical case differently in paper- and simulation-based workshops. British Journal of Educational Technology, Advance Online Publication. doi: 10.1111/j.1467-8535.2010.01113.x Lovelock, B., Lovelock, K., & Normann, Ø. (2010). The big catch: Negotiating the transition from commercial fisher to tourism entrepreneur in island environments. Asia Pacific Journal of Tourism Research, 15(3), 267-283. doi: 10.1080/10941665.2010.503616

262 RESEARCH REPORT 2009/2010 Lovelock, K. (2010). Conceiving reproduction: New reproductive technologies and the redefinition of the kinship narrative in New Zealand society. Anthropological Forum, 20(2), 125-146. doi: 10.1080/00664677.2010.487296 McDowell, A., McLeod, B. J., Rades, T., & Tucker, I. G. (2009). Polymeric nanoparticles as an oral delivery system for biocontrol agents for the brushtail possum (Trichosurus vulpecula). New Zealand Veterinary Journal, 57(6), 370-377. McGree, J. M., Eccleston, J. A., & Duffull, S. B. (2009). Simultaneous versus sequential optimal design for pharmacokinetic- pharmacodynamic models with FO and FOCE considerations. Journal of Pharmacokinetics and Pharmacodynamics, 36(2), 101-123. doi: 10.1007/s10928-009-9113-0 Mould, D. R., Sweeney, K., Duffull, S. B., Neylon, E., Hamlin, P., Horwitz, S., et al. (2009). A population pharmacokinetic and pharmacodynamic evaluation of pralatrexate in patients with relapsed or refractory non-Hodgkin’s or Hodgkin’s lymphoma. Clinical Pharmacology & Therapeutics, 86(2), 190-196. doi: 10.1038/clpt.2009.80 Murphy, J. E., Green, J. S., Adams, L. A., Squire, R. B., Kuo, G. M., & McKay, A. (2010). Pharmacogenomics in the curricula of colleges and schools of pharmacy in the United States. American Journal of Pharmaceutical Education, 74(1), 7. Müllertz, A., Ogbonna, A., Ren, S., & Rades, T. (2010). New perspectives on lipid and surfactant based drug delivery systems for oral delivery of poorly soluble drugs. Journal of Pharmacy and Pharmacology, 62(11), 1622-1636. doi: 10.1111/j.2042- 7158.2010.01107.x Myschik, J., Rades, T., & Hook, S. (2009). Advances in lipid-based subunit vaccine formulations. Current Immunology Reviews, 5(1), 42-48. Nath, C. E., Shaw, P. J., Trotman, J., Zeng, L., Duffull, S. B., Hegarty, G., et al. (2010). Population pharmacokinetics of melphalan in patients with multiple myeloma undergoing high dose therapy. British Journal of Clinical Pharmacology, 69(5), 484-497. doi: 10.1111/1365-2125.2010.03638.x Nisa, S., Blokpoel, M. C. J., Robertson, B. D., Tyndall, J. D. A., Lun, S., Bishai, W. R., & O’Toole, R. (2010). Targeting the chromosome partitioning protein ParA in tuberculosis drug discovery. Journal of Antimicrobial Chemotherapy, 65(11), 2347-2358. doi: 10.1093/jac/dkq311 Norris, P., Chong, C. E., Chou, A., Hsu, T-H., Lee, C-C., Kuei-Lien Su, C., & Wang, Y. (2009). Knowledge and reported use of antibiotics amongst school-teachers in New Zealand. Pharmacy Practice, 7(4), 238-241. Norris, P., Churchward, M., Fa’alau, F., & Va’ai, C. (2009). Understanding and use of antibiotics amongst Samoan people in New Zealand. Journal of Primary Health Care, 1(1), 30-35. Norris, P., Fa’alau, F., Va’ai, C., Churchward, M., & Arroll, B. (2009). Navigating between illness paradigms: Treatment seeking by Samoan people in Samoa and New Zealand. Qualitative Health Research, 19(10), 1466-1475. doi: 10.1177/1049732309348364 Norris, P., Horsburgh, S., Padukkage, P., Baik, N. Y. T., Kim, D., Fussell, A., Hutchinson, S., & Ragupathy, R. (2010). Coverage and accuracy of ethnicity data on three Asian ethnic groups in New Zealand. Australian and New Zealand Journal of Public Health, 34(3), 258-261. doi: 10.1111/j.1753-6405.2010.00523.x Norris, P., Ng, L. F., Kershaw, V., Hanna, F., Wong, A., Talekar, M., Oh, J., Azer, M., & Cheong, L. (2010). Knowledge and reported use of antibiotics amongst immigrant ethnic groups in New Zealand. Journal of Immigrant and Minority Health, 12(1), 107-112. doi: 10.1007/s10903-008-9224-5 Norris, P., Va’ai, C., Fa’alau, F., Churchward, M., & Arroll, B. (2010). Pain, infection, and colds and flu: Samoan people’s views about antibiotics. Research in Social and Administrative Pharmacy, Advance Online Publication. doi: 10.1016/j. sapharm.2010.01.002 Page, C. B., Duffull, S. B., Whyte, I. M., & Isbister, G. K. (2009). Promethazine overdose: Clinical effects, predicting delirium and the effect of charcoal. QJM, 102(2), 123-131. doi: 10.1093/qjmed/hcn153 Parr, W. V., Valentin, D., Green, J. A., & Dacremont, C. (2010). Evaluation of French and New Zealand Sauvignon wines by experienced French wine assessors. Food Quality & Preference, 21(1), 56-64. doi: 10.1016/j.foodqual.2009.08.002 Patel, A., Gauld, R., Norris, P., & Rades, T. (2010). ²This body does not want free medicines²: South African consumer perceptions of drug quality. Health Policy and Planning, 25(1), 61-69. doi: 10.1093/heapol/czp039 Patel, A., Norris, P., Gauld, R., & Rades, T. (2009). Drug quality in South Africa: Perceptions of key players involved in medicines distribution. International Journal of Health Care Quality Assurance, 22(5), 547-560. doi: 10.1108/09526860910975643 Pavan Kumar, V. V., & Duffull, S. B. (2010). Evaluation of graphical diagnostics for assessing goodness of fit of logistic regression models. Journal of Pharmacokinetics & Pharmacodynamics, Advance Online Publication. doi: 10.1007/s10928- 010-9189-6 Peake, B. M., & Braund, R. (2009). Environmental aspects of the disposal of pharmaceuticals in New Zealand. Chemistry in New Zealand, 73(2), 58-63. Ragupathy, R., Tordoff, J., Norris, P., & Reith, D. (2010). Access to children’s medicines in the United Kingdom, Australia and New Zealand in 1998, 2002 and 2007. Pharmacy World and Science, 32, 386-393. doi: 10.1007/s11096-010-9383-z Reith, D., Medlicott, N. J., Kumara De Silva, R., Yang, L., Hickling, J., & Zacharias, M. (2009). Simultaneous modelling of the Michaelis-Menten kinetics of paracetamol sulphation and glucuronidation. Clinical and Experimental Pharmacology and Physiology, 36(1), 35-42. doi: 10.1111/j.1440-1681.2008.05029.x Rios, E. R. V., Rocha, N. F. M., Venâncio, E. T., ..., Woods, D. J., et al. (2010). Mechanisms involved in the gastroprotective activity of esculin on acute gastric lesions in mice. Chemico-Biological Interactions, Advance Online Publication. doi: 10.1016/j.cbi.2010.07.020

Division of HEALTH SCIENCES 263 Rizwan, S. B., Boyd, B. J., Rades, T., & Hook, S. (2010). Bicontinuous cubic liquid crystals as sustained delivery systems for peptides and proteins. Expert Opinion Drug Delivery, 7(10), 1133-1144. doi: 10.1517/17425247.2010.515584 Rizwan, S. B., Hanley, T., Boyd, B. J., Rades, T., & Hook, S. (2009). Liquid crystalline systems of phytantriol and glyceryl monooleate containing a hydrophilic protein: Characterisation, swelling and release kinetics. Journal of Pharmaceutical Sciences, 98(11), 4191-4204. doi: 10.1002/jps.21724 Ruiz-Gómez, G., Tyndall, J. D. A., Pfeiffer, B., Abbenante, G., & Fairlie, D. P. (2010). Update 1 of: Over one hundred peptide- activated G protein-coupled receptors recognize ligands with turn structure. Chemical Reviews, 110, PR1-PR41. doi: 10.1021/cr900344w Sassene, P. J., Knopp, M. M., Hesselkilde, J. Z., Koradia, V., Rades, T., & Müllertz, A. (2010). Precipitation of a poorly soluble model drug during in vitro lipolysis: Characterization and dissolution of the precipitate. Journal of Pharmaceutical Sciences, 99(12), 4982-4991. doi: 10.1002/jps.22226 Savolainen, M., Kogermann, K., Heinz, A., Aaltonen, J., Peltonen, L., Strachan, C., & Yliruusi, J. (2009). Better understanding of dissolution behaviour of amorphous drugs by in situ solid-state analysis using Raman spectroscopy. European Journal of Pharmaceutics and Biopharmaceutics, 71(1), 71-79. doi: 10.1016/j.ejpb.2008.06.001 Sawant, P. M., Tyndall, J. D. A., Holland, P. T., Peake, B. M., Mountfort, D. O., & Kerr, D. S. (2010). In vivo seizure induction and affinity studies of domoic acid and isodomoic acids-D, -E and -F. Neuropharmacology, 59, 129-138. doi: 10.1016/j. neuropharm.2010.03.019 Sehgal, P., Sopoaga, F., & Beresford, R. (2009). Bridging the gap: Strategies to promote the recruitment and retention of Pacific Islanders into the health professions. New Zealand Medical Students Journal, 9, 5-8. Sharp, C. F., Gardiner, S. J., Jensen, B. P., Roberts, R. L., Troughton, R. W., Lainchbury, J. G., & Begg, E. J. (2009). CYP2D6 genotype and its relationship with metoprolol dose, concentrations and effect in patients with systolic heart failure. Pharmacogenomics Journal, 9(3), 175-184. doi: 10.1038/tpj.2009.9 Sherwin, C. M. T., Kostan, E., Broadbent, R. S., Medlicott, N. J., & Reith, D. M. (2009). Evaluation of the effect of intravenous volume expanders upon the volume of distribution of gentamicin in septic neonates. Biopharmaceutics & Drug Disposition, 30(5), 276-280. doi: 10.1002/bdd.666 Sherwin, C. M. T., McCaffrey, F., Broadbent, R. S., Reith, D. M., & Medlicott, N. J. (2009). Discrepancies between predicted and observed rates of intravenous gentamicin delivery for neonates. Journal of Pharmacy and Pharmacology, 61(4), 465-471. doi: 10.1211/jpp/61.04.0008 Si, D., Wang, Y., Zhou, Y-H., Guo, Y., Wang, J., Zhou, H., Li, Z-S., & Fawcett, J. P. (2009). Mechanism of CYP2C9 inhibition by flavones and flavonols. Drug Metabolism and Disposition, 37(3), 629-634. doi: 10.1124/dmd.108.023416 Simovic, S., Heard, P., Hui, H., ..., Rades, T., & Prestidge, C. A. (2009). Dry hybrid lipid-silica microcapsules engineered from submicron lipid droplets and nanoparticles as a novel delivery system for poorly soluble drugs. Molecular Pharmaceutics, 6(3), 861-872. doi: 10.1021/mp900063t Simovic, S., Hui, H., Song, Y., Davey, A. K., Rades, T., & Prestidge, C. A. (2010). An oral delivery system for indomethicin engineered from cationic lipid emulsions and silica nanoparticles. Journal of Controlled Release, 143, 367-373. doi: 10.1016/j.jconrel.2010.01.008 Simpson, J. A., Jamsen, K. M., Price, R. N., White, N. J., Lindegardh, N., Tarning, J., & Duffull, S. B. (2009). Towards optimal design of anti-malarial pharmacokinetic studies. Malaria Journal, 8, 189. doi: 10.1186/1475-2875-8-189 Songkro, S., Rades, T., & Becket, G. (2009). Effects of some terpenes on the in vitro permeation of LHRH through newborn pig skin. Pharmazie, 64(2), 110-115. doi: 10.1691/ph.2009.8243 Strachan, C. J., Windbergs, M., & Offerhaus, H. L. (2010). Pharmaceutical applications of non-linear imaging. International Journal of Pharmaceutics, Advance Online Publication. doi: 10.1016/j.ijpharm.2010.12.017 Sun, Y., Liu, M., Zhang, J., Jiang, Y., Yu, W., Fawcett, J. P., & Gu, J. (2009). Rapid and sensitive assay for trantinterol, a

novel b2-adrenoceptor agonist, in human plasma using liquid chromatography-tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 49(4), 1056-1059. doi: 10.1016/j.jpba.2009.01.012 Tan, A., Simovic, S., Davey, A. K., Rades, T., Boyd, B. J., & Prestidge, C. A. (2010). Silica nanoparticles to control the lipase- mediated digestion of lipid-based oral delivery systems. Molecular Pharmaceutics, 7(2), 522-532. doi: 10.1021/mp9002442 Tan, A., Simovic, S., Davey, A. K., Rades, T., & Prestidge, C. A. (2009). Silica-lipid hybrid (SLH) microcapsules: A novel oral delivery system for poorly soluble drugs. Journal of Controlled Release, 134(1), 62-70. doi: 10.1016/j.jconrel.2008.10.014 Tantipolphan, R., Rades, T., & Medlicott, N. J. (2009). Swelling lecithin: Cholesterol implants for the controlled release of proteins. Journal of Liposome Research, 19(1), 37-48. doi: 10.1080/08982100802636434 Thompson, A., Lovelock, B., Reis, A., Kjelsberg, M., Sides, G., Wright, R., & Jellum, C. (2009). Traditional livelihoods, conservation and recreation: Reflections on managing visitation in New Zealand conservation parks. Tourismos, 4(4), 163-179. Tong, A. Y. C., Peake, B. M., & Braund, R. (2010). Disposal practices for unused medications around the world. Environment International, 37, 292-298. doi: 10.1016/j.envint.2010.10.002 Tordoff, J. M., Bagge, M. L., Gray, A. R., Campbell, A. J., & Norris, P. T. (2010). Medicine-taking practices in community- dwelling people aged ³75 years in New Zealand. Age and Ageing, 39(5), 574-580. doi: 10.1093/ageing/afq069 Tordoff, J., Simonsen, K., Thomson, W. M., & Norris, P. T. (2010). ²It’s just routine.²: A qualitative study of medicine-taking amongst older people in New Zealand. Pharmacy World & Science, 32, 154-161. doi: 10.1007/s11096-009-9361-5 Urdapilleta, I., Parr, W., Dacremont, C., & Green, J. (2010). Semantic and perceptive organisation of sauvignon blanc wine characteristics: Influence of expertise. Food Quality and Preference, Advance Online Publication. doi: 10.1016/j. foodqual.2010.08.005

264 RESEARCH REPORT 2009/2010 Vasconcelos Rios, E. R., Teles Venâncio, E., Moura Rocha, N. F., Woods, D. J., Vasconcelos, S., Macedo, D., et al. (2010). Melatonin: Pharmacological aspects and clinical trends. International Journal of Neuroscience, 120(9), 583-590. doi: 10.3109/00207454.2010.492921 Wajima, T., Isbister, G. K., & Duffull, S. B. (2009). A comprehensive model for the humoral coagulation network in humans. Clinical Pharmacology and Therapeutics, 86(3), 290-298. doi: 10.1038/clpt.2009.87 Waterhouse, T. H., Eccleston, J. A., & Duffull, S. B. (2009). Optimal design criteria for discrimination and estimation in nonlinear models. Journal of Biopharmaceutical Statistics, 19(2), 386-402. doi: 10.1080/10543400802677257 Westphal, D., Ledgerwood, E. C., Tyndall, J. D. A., Hibma, M. H., Ueda, N., Fleming, S. B., & Mercer, A. A. (2009). The orf virus inhibitor of apoptosis functions in a Bcl-2-like manner, binding and neutralizing a set of BH3-only proteins and active Bax. Apoptosis, 14(11), 1317-1330. doi: 10.1007/s10495-009-0403-1 Windbergs, M., Gueres, S., Strachan, C. J., & Kleinebudde, P. (2010). Two-step solid lipid extrusion as a process to modify dissolution behavior. AAPS PharmSciTech, 11(1), 2-8. doi: 10.1208/s12249-010-9395-y Windbergs, M., Haaser, M., McGoverin, C. M., Gordon, K. C., Kleinebudde, P., & Strachan, C. J. (2010). Investigating the relationship between drug distribution in solid lipid matrices and dissolution behaviour using Raman spectroscopy and mapping. Journal of Pharmaceutical Sciences, 99(3), 1464-1475. doi: 10.1002/jps.21894 Windbergs, M., Jurna, M., Offerhaus, H. L., Herek, J. L., Kleinebudde, P., & Strachan, C. J. (2009). Chemical imaging of oral solid dosage forms and changes upon dissolution using coherent anti-Stokes Raman scattering microscopy. Analytical Chemistry, 81(6), 2085-2091. doi: 10.1021/ac8020856 Windbergs, M., Strachan, C. J., & Kleinebudde, P. (2009). Influence of structural variations on drug release from lipid/ polyethylene glycol matrices. European Journal of Pharmaceutical Sciences, 37(5), 555-562. doi: 10.1016/j.ejps.2009.04.010 Windbergs, M., Strachan, C. J., & Kleinebudde, P. (2009). Influence of the composition of glycerides on the solid-state behaviour and the dissolution profiles of solid lipid extrudates. International Journal of Pharmaceutics, 381(2), 184-191. doi: 10.1016/j.ijpharm.2009.03.002 Windbergs, M., Strachan, C. J., & Kleinebudde, P. (2009). Investigating the principles of recrystallization from glyceride melts. AAPS PharmSciTech, 10(4), 1224-1233. doi: 10.1208/s12249-009-9311-5 Windbergs, M., Strachan, C. J., & Kleinebudde, P. (2009). Tailor-made dissolution profiles by extruded matrices based on lipid polyethylene glycol mixtures. Journal of Controlled Release, 137(3), 211-216. doi: 10.1016/j.jconrel.2009.04.002 Wiranidchapong, C., Rades, T., Kulvanich, P., & Tucker, I. G. (2009). Method of preparation does not affect the miscibility between steroid hormone and polymethacrylate. Thermochimica Acta, 485(1-2), 57-64. doi: 10.1016/j.tca.2008.12.013 Wright, D. F. B., Al-Sallami, H. S., Jackson, P. M., & Reith, D. M. (2010). Falsely elevated vancomycin plasma concentrations sampled from central venous implantable catheters (portacaths). British Journal of Clinical Pharmacology, 70(5), 769-772. doi: 10.1111/j.1365-2125.2010.03749.x Wright, D. F. B., & Begg, E. J. (2010). The ‘apparent clearance’ of free phenytoin in elderly vs. younger adults. British Journal of Clinical Pharmacology, 70(1), 132-138. doi: 10.1111/j.1365-2125.2010.03673.x Wu, X., Liu, L., Zhang, M., Wu, D., Wang, Y., Sun, Y., Fawcett, J. P., et al. (2010). Simultaneous analysis of isomers of escin saponins in human plasma by liquid chromatography-tandem mass spectrometry: Application to a pharmacokinetic study after oral administration. Journal of Chromatography B, 878, 861-867. doi: 10.1016/j.jchromb.2010.02.002 Wu, Z., Tucker, I. G., Razzak, M., McSporran, K., & Medlicott, N. J. (2010). Tissue compatibility and pharmacokinetics of three potential subcutaneous injectables for low-pH drug solutions. Journal of Pharmacy and Pharmacology, 62(7), 873-882. doi: 10.1211/jpp.62.07.0008 Wu, Z., Tucker, I. G., Razzak, M., & Medlicott, N. J. (2009). Stability of ricobendazole in aqueous solutions. Journal of Pharmaceutical and Biomedical Analysis, 49(5), 1282-1286. doi: 10.1016/j.jpba.2009.02.032 Wu, Z., Tucker, I. G., Razzak, M., Yang, L., McSporran, K., & Medlicott, N. J. (2010). Absorption and tissue tolerance of ricobendazole in the presence of hydroxypropyl-b-cyclodextrin following subcutaneous injection in sheep. International Journal of Pharmaceutics, 397, 96-102. doi: 10.1016/j.ijpharm.2010.07.002 Yang, J., He, Y., Du, Y-X., Tang, L-L., Wang, G-J., & Fawcett, J. P. (2009). Pharmacokinetic properties of S-adenosylmethionine after oral and intravenous administration of its tosylate disulfate salt: A multiple-dose, open-label, parallel-group study in healthy Chinese volunteers. Clinical Therapeutics, 31(2), 311-320. doi: 10.1016/j.clinthera.2009.02.010 Yang, L., Zhang, H., Fawcett, J. P., Mikov, M., & Tucker, I. G. (2010). Effect of bile salts on the transport of morphine-6- glucuronide in rat brain endothelial cells. Journal of Pharmaceutical Sciences, Advance Online Publication. doi: 10.1002/ jps.22390 Yang, L., Zhang, H., Mikov, M., & Tucker, I. G. (2009). Physicochemical and biological characterization of monoketocholic acid, a novel permeability enhancer. Molecular Pharmaceutics, 6(2), 448-456. doi: 10.1021/mp800143w Yeo, T. W., Lampah, D. A., Tjitra, E., ..., Duffull, S. B., et al. (2009). Relationship of cell-free hemoglobin to impaired endothelial nitric oxide bioavailability and perfusion in severe falciparum malaria. Journal of Infectious Diseases, 200(10), 1522-1529. doi: 10.1086/644641 Yeo, T. W., Lampah, D. A., Tjitra, E., ..., Duffull, S. B., et al. (2010). Increased asymmetric dimethylarginine in severe falciparum malaria: Association with impaired nitric oxide bioavailability and fatal outcome. PLoS Pathogens, 6(4), e1000868. doi: 10.1371/journal.ppat.1000868 Young, L., Lawes, F., Tordoff, J., Norris, P., & Reith, D. (2009). Access to prescribing information for paediatric medicines in the USA: Post-modernization. British Journal of Clinical Pharmacology, 67(3), 341-346. doi: 10.1111/j.1365-2125.2008.03356.x Yu, W., Wang, Y., Zhang, Y., Zhang, D., Lan, J., Liu, Z., Gu, J., & Fawcett, J. P. (2009). Quantitation of bergenin in human plasma by liquid chromatography/tandem mass spectrometry. Journal of Chromatography B, 877(1), 33-36. doi: 10.1016/j. jchromb.2008.11.005

Division of HEALTH SCIENCES 265 Zhang, C., Wang, L., Guan, X., Fawcett, J. P., Zhao, L-m., Sun, Y-t., & Gu, J-K. (2010). Rapid determination of ranitidine in human plasma by liquid chromatography-tandem mass spectrometry and its application to a clinical pharmacokinetic study. Chemical Research in Chinese Universities, 26(6), 910-914. Zhang, C., Wang, L., Yang, W., Wang, X., Fawcett, J. P., Sun, Y., & Gu, J. (2009). Validated LC-MS/MS assay for the determination of felbinac: Application to a preclinical pharmacokinetics study of felbinac trometamol injection in rat. Journal of Pharmaceutical and Biomedical Analysis, 50(1), 41-45. doi: 10.1016/j.jpba.2009.03.019 Zhang, D., Wang, Y., Han, J., Yu, W., Deng, L., Fawcett, J. P., Liu, Z., & Gu, J. (2009). Rapid and sensitive LC-MS/MS assay for the quantitation of 20(S)-protopanaxadiol in human plasma. Journal of Chromatography B, 877(5-6), 581-585. doi: 10.1016/j.jchromb.2009.01.009 Zhang, F., Aaltonen, J., Tian, F., Saville, D. J., & Rades, T. (2009). Influence of particle size and preparation methods on the physical and chemical stability of amorphous simvastatin. European Journal of Pharmaceutics and Biopharmaceutics, 71(1), 64-70. doi: 10.1016/j.ejpb.2008.07.010 Zhong, S., Shen, Y-C., Ho, L., May, R. K., Zeitler, J. A., Evans, M., Taday, P. F., Pepper, M., Rades, T., Gordon, K. C., Müller, R., & Kleinebudde, P. (2010). Non-destructive quantification of pharmaceutical tablet coatings using terahertz pulsed imaging and optical coherence tomography. Optics and Lasers in Engineering, Advance Online Publication. doi: 10.1016/j. optlaseng.2010.11.003 Zin, C. S., Nissen, L. M., O’Callaghan, J. P., Duffull, S. B., Smith, M. T., & Moore, B. J. (2010). A randomized, controlled trial of oxycodone versus placebo in patients with postherpetic neuralgia and painful diabetic neuropathy treated with pregabalin. Journal of Pain, 11(5), 462-471. doi: 10.1016/j.jpain.2009.09.003

Journal - Research Other Al-Sallami, H., Jordan, S., Ferguson, R., Medlicott, N. J., Schollum, J., & Duffull, S. B. (2010). Current enoxaparin dosing guidelines have dubious credibility [Viewpoint]. New Zealand Medical Journal, 123(1313). Retrieved from http://www. nzma.org.nz/journal/archive.shtml Bork, O. (2009). Is there a need for further research on intramammary drug delivery systems for treating bovine mastitis? Controlled Release Society Newsletter, 26(2), 14-15. Han, P. Y., Duffull, S. B., Kirkpatrick, C. M. J., & Green, B. (2009). Response to “Influence of lean body weight on anticancer drug clearance” [Letter to the editor]. Clinical Pharmacology and Therapeutics, 85(1), 24. doi: 10.1038/clpt.2008.210 Norris, P. T. (2009). Challenges facing social pharmacy [Editorial]. Research in Social and Administrative Pharmacy, 5(3), 195- 196. doi: 10.1016/j.sapharm.2009.03.001 O’Shea, S., Duffull, S., & Johnson, D. W. (2009). Aminoglycosides in hemodialysis patients: Is the current practice of post dialysis dosing appropriate? [Editorial]. Seminars in Dialysis, 22(3), 225-230. doi: 10.1111/j.1525-139X.2008.00554.x Sherwin, C. M. T., Broadbent, R. S., Medlicott, N. J., & Reith, D. M. (2009). Individualised dosing of amikacin in neonates [Letter to the editor]. European Journal of Clinical Pharmacology, 65(12), 1267-1268. doi: 10.1007/s00228-009-0691-y Sherwin, C. M. T., Svahn, S., Van Der Linden, A., Broadbent, R. S., Medlicott, N. J., & Reith, D. M. (2009). Individualised dosing of amikacin in neonates: A pharmacokinetic/pharmacodynamic analysis. European Journal of Clinical Pharmacology, 65(7), 705-713. doi: 10.1007/s00228-009-0637-4

Working Paper; Discussion Paper; Technical Report Horsburgh, S., Malik, M., Norris, P., Harrison-Woolrych, M., Tordoff, J., Becket, G., Herbison, P., Parkin, L., & Reith, D. (2009). Prescribing and dispensing data sources in New Zealand: Their usage and future directions [Technical Report No. 001/09]. Dunedin, New Zealand: School of Pharmacy, University of Otago. (pp. 1-63).

SCHOOL OF PHYSIOTHERAPY

Edited Book - Other Higgs, J., Smith, M., Webb, G., Skinner, M., & Croker, A. (Eds.). (2009). Contexts of physiotherapy practice. Sydney, Australia: Churchill Livingstone, 340p.

Chapter in Book - Research Baxter, G. D., & Basford, J. R. (2009). Overview of other electrophysical and thermal agents. In K. A. Sluka (Ed.), Mechanisms and management of pain for the physical therapist (pp. 191-204). Seattle, WA: IASP Press. Sluka, K. A., & Milosavljevic, S. (2009). Manual therapy. In K. A. Sluka (Ed.), Mechanisms and management of pain for the physical therapist (pp. 205-216). Seattle, WA: IASP Press.

Chapter in Book - Other Baxter, D., & Nall, C. (2009). Current trends in physiotherapy practice. In J. Higgs, M. Smith, G. Webb, M. Skinner, & A. Croker (Eds.), Contexts of physiotherapy practice (pp. 20-32). Sydney, Australia: Churchill Livingstone. Croker, A., Bent, A., & Milosavljevic, S. (2009). Working in rural and remote physiotherapy. In J. Higgs, M. Smith, G. Webb, M. Skinner, & A. Croker (Eds.), Contexts of physiotherapy practice (pp. 151-163). Sydney, Australia: Churchill Livingstone. Hale, L., Croker, A., & Tasker, D. (2009). The expansion of community-based physiotherapy. In J. Higgs, M. Smith, G. Webb, M. Skinner, & A. Croker (Eds.), Contexts of physiotherapy practice (pp. 139-150). Sydney, Australia: Churchill Livingstone.

266 RESEARCH REPORT 2009/2010 Skinner, M., Bithell, C., Mitsch, D., & Walsh, M. (2009). Career pathways and professional development. In J. Higgs, M. Smith, G. Webb, M. Skinner, & A. Croker (Eds.), Contexts of physiotherapy practice (pp. 75-89). Sydney, Australia: Churchill Livingstone. Webb, G., Skinner, M., Jones, S., Vicenzino, B., Nall, C., & Baxter, D. (2009). Physiotherapy in the 21st century. In J. Higgs, M. Smith, G. Webb, M. Skinner, & A. Croker (Eds.), Contexts of physiotherapy practice (pp. 3-19). Sydney, Australia: Churchill Livingstone.

Journal - Research Article Abbott, J. H., Flynn, T. W., Fritz, J. M., Hing, W. A., Reid, D., & Whitman, J. M. (2009). Manual physical assessment of spinal segmental motion: Intent and validity. Manual Therapy, 14(1), 36-44. doi: 10.1016/j.math.2007.09.011 Abbott, J. H., Robertson, M. C., McKenzie, J. E., Baxter, G. D., Theis, J-C., Campbell, A. J., & the MOA Trial Team (2009). Exercise therapy, manual therapy, or both, for osteoarthritis of the hip or knee: A factorial randomised controlled trial protocol. Trials, 10(11). doi: 10.1186/1745-6215-10-11 Abou Hassan, J., Milosavljevic, S., & Carman, A. (2010). Can postural modification reduce kinetic and kinematic loading during the bowing postures of Islamic prayer? Ergonomics, 53(12), 1446-1454. doi: 10.1080/00140139.2010.532881 Ahmed, O. H., Sullivan, S. J., Schneiders, A. G., & McCrory, P. (2010). iSupport: Do social networking sites have a role to play in concussion awareness? Disability and Rehabilitation, 32(22), 1877-1883. doi: 10.3109/09638281003734409 Alla, S., Sullivan, S. J., Hale, L., & McCrory, P. (2009). Self-report scales/checklists for the measurement of concussion symptoms: A systematic review. British Journal of Sports Medicine, 43(Suppl 1), i3-i12. doi: 10.1136/bjsm.2009.058339 Alla, S., Sullivan, S. J., McCrory, P., & Hale, L. (2010). Spreading the word on sports concussion: Citation analysis of summary and agreement, position and consensus statements on sports concussion. British Journal of Sports Medicine, Advance Online Publication. doi: 10.1136/bjsm.2010.074088 Alla, S., Sullivan, S. J., McCrory, P., Schneiders, A. G., & Handcock, P. (2010). Does exercise evoke neurological symptoms in healthy subjects? Journal of Science and Medicine in Sport, 13, 24-26. doi: 10.1016/j.jsams.2008.12.629 Asay, J. L., Mündermann, A., & Andriacchi, T. P. (2009). Adaptive patterns of movement during stair climbing in patients with knee osteoarthritis. Journal of Orthopaedic Research, 27(3), 325-329. doi: 10.1002/jor.20751 Baxter, G. D., Chow, R., Armati, P., Bjordal, J. M., & Laakso, L. (2009). Effects of laser irradiation on peripheral nerve. AIP Conference Proceedings, 1142(1), 45-48. doi: 10.1063/1.3175627 Becker, I., Baxter, G. D., & Woodley, S. J. (2010). The vastus lateralis muscle: An anatomical investigation. Clinical Anatomy, 23, 575-585. doi: 10.1002/ca.20974 Becker, I., Woodley, S. J., & Baxter, G. D. (2009). Gross morphology of the vastus lateralis muscle: An anatomical review. Clinical Anatomy, 22(4), 436-450. doi: 10.1002/ca.20792 Bennell, K., Egerton, T., Pua, Y-H., Abbott, J. H., et al. (2010). Efficacy of a multimodal physiotherapy treatment program for hip osteoarthritis: A randomised placebo-controlled trial protocol. BMC Musculoskeletal Disorders, 11, 238. doi: 10.1186/1471-2474-11-238 Braund, R., & Abbott, J. H. (2010). Recommending NSAIDs and paracetamol: A survey of New Zealand physiotherapists’ knowledge and behaviours. Physiotherapy Research International, Advance Online Publication. doi: 10.1002/pri.472 Bronson, C., Brewerton, K., Ong, J., Palanca, C., & Sullivan, S. J. (2010). Does hippotherapy improve balance in persons with multiple sclerosis: A systematic review. European Journal Physical Rehabilitation Medicine, 46(3), 347-353. Brown, M., Dean, S., Hay-Smith, E. J. C., Taylor, W., & Baxter, G. D. (2010). Musculoskeletal pain and treatment choice: An exploration of illness perceptions and choices of conventional or complementary therapies. Disability and Rehabilitation, 32(20), 1645-1657. doi: 10.3109/09638281003649896 Burch, C., Guthrie, P., Kidd, M., Lewis, C., & Smiler, P. (2010). Near-peer learning in clinical education: A systematic review. Focus on Health Professional Education, 11(3), 1-21. Bussey, M. D., Bell, M. L., & Milosavljevic, S. (2009). The influence of hip abduction and external rotation on sacroiliac motion. Manual Therapy, 14(5), 520-525. doi: 10.1016/j.math.2008.08.009 Bussey, M. D., Milosavljevic, S., & Bell, M. L. (2009). Sex differences in the pattern of innominate motion during passive hip abduction and external rotation. Manual Therapy, 14(5), 514-519. doi: 10.1016/j.math.2008.09.004 Camargo Forte, F., Peduzzi de Castro, M., Mahnic de Toledo, J., Cury Ribeiro, D., & Fagundes Loss, J. (2009). Scapular kinematics and scapulohumeral rhythm during resisted shoulder abduction: Implications for clinical practice. Physical Therapy in Sport, 10(3), 105-111. doi: 10.1016/j.ptsp.2009.05.005 Carman, A. B., Gillespie, S., Jones, K., Mackay, J., Wallis, G., & Milosavljevic, S. (2010). All terrain vehicle loss of control events in agriculture: Contribution of pitch, roll and velocity. Ergonomics, 53(1), 18-29. doi: 10.1080/00140130903380919 Castinel, B. H., Adam, P., Milburn, P. D., Castinel, A., Quarrie, K. L., Peyrin, J-C., & Yeo, J. D. (2010). Epidemiology of cervical spine abnormalities in asymptomatic adult professional rugby union players using static and dynamic MRI protocols: 2002 to 2006. British Journal of Sports Medicine, 44(3), 194-199. doi: 10.1136/bjsm.2007.045815 Chung, T-Y., Peplow, P. V., & Baxter, G. D. (2010). Laser photobiomodulation of wound healing in diabetic and non- diabetic mice: Effects in splinted and unsplinted wounds. Photomedicine and Laser Surgery, 28(2), 251-261. doi: 10.1089/ pho.2009.2493 Chung, T-Y., Peplow, P. V., & Baxter, G. D. (2010). Laser photobiostimulation of wound healing: Defining a dose response for splinted wounds in diabetic mice. Lasers in Surgery and Medicine, 42(9), 656-664. doi: 10.1002/lsm.20981 Chung, T-Y., Peplow, P. V., & Baxter, G. D. (2010). Testing photobiomodulatory effects of laser irradiation on wound healing: Development of an improved model for dressing wounds in mice. Photomedicine and Laser Surgery, 28(5), 589-596. doi: 10.1089/pho.2009.2641

Division of HEALTH SCIENCES 267 Cleland, J. A., Abbott, J. H., Kidd, M. O., Stockwell, S., Cheney, S., Gerrard, D. F., & Flynn, T. W. (2009). Manual physical therapy and exercise versus electrophysical agents and exercise in the management of plantar heel pain: A multicenter randomized clinical trial. Journal of Orthopaedic and Sports Physical Therapy, 39(8), 573-585. doi: 10.2519/jospt.2009.3036 Crowe, M., Whitehead, L., Gagan, M. J., Baxter, D., & Panckhurst, A. (2010). Self-management and chronic low back pain: A qualitative study. Journal of Advanced Nursing, 66(7), 1478-1486. doi: 10.1111/j.1365-2648.2010.05316.x Crowe, M., Whitehead, L., Gagan, M. J., Baxter, G. D., Panckhurst, A., & Valledor, V. (2010). Listening to the body and talking to myself: The impact of chronic lower back pain: A qualitative study. International Journal of Nursing Studies, 47, 586-592. doi: 10.1016/j.ijnurstu.2009.09.012 Cury Ribeiro, D., & Fagundes Loss, J. (2010). Assessment of the propagation of uncertainty on link segment model results. Motor Control, 14(4), 411-423. Erhart, J. C., Mündermann, A., Elspas, B., Giori, N. J., & Andriacchi, T. P. (2010). Changes in knee adduction moment, pain, and functionality with a variable-stiffness walking shoe after 6 months. Journal of Orthopaedic Research, 28(7), 873-879. doi: 10.1002/jor.21077 Fullen, B. M., Baxter, G. D., O’Donovan, B. G. G., Doody, C., Daly, L. E., & Hurley, D. A. (2009). Factors impacting on doctors’ management of acute low back pain: A systematic review. European Journal of Pain, 13(9), 908-914. doi: 10.1016/j. ejpain.2008.11.013 Gregg, C. D., Dean, S., & Schneiders, A. G. (2009). Variables associated with active spondylolysis. Physical Therapy in Sport, 10, 121-124. doi: 10.1016/j.ptsp.2009.08.001 Gregory, D. E., Laughton, C., Carman, A., Milosavljevic, S., & Callaghan, J. P. (2009). Trunk postures and peak and cumulative low back kinetics during upright posture sheep shearing. Ergonomics, 52(12), 1576-1583. doi: 10.1080/00140130903287973 Gregory, D. E., Pal, P., Carman, A., Milosavljevic, S., & Callaghan, J. P. (2009). An examination of shoulder postures and moments of force among different skill levels in the wool harvesting industry. International Journal of Occupational Safety and Ergonomics, 15(4), 409-418. Hale, L. A. (2010). Using goal attainment scaling in physiotherapeutic home-based stroke rehabilitation. Advances in Physiotherapy, 12(3), 142-149. doi: 10.3109/14038196.2010.486040 Hale, L. A., Nukada, H., Du Plessis, L. J., & Peebles, K. C. (2009). Clinical screening of autonomic dysfunction in multiple sclerosis. Physiotherapy Research International, 14(1), 42-55. doi: 10.1002/pri.416 Hale, L., McIlraith, L., Miller, C., Stanley-Clarke, T., & George, R. (2010). The interrater reliability of the modified Gait Abnormality Rating Scale for use with people with intellectual disability. Journal of Intellectual & Developmental Disability, 35(2), 77-81. doi: 10.3109/13668251003702128 Hale, L., Miller, R., Barach, A., Skinner, M., & Gray, A. (2009). Motor Control Test responses to balance perturbations in adults with an intellectual disability. Journal of Intellectual & Developmental Disability, 34(1), 81-86. Harland, T., Tidswell, T., Everett, D., Hale, L., & Pickering, N. (2010). Neoliberalism and the academic as critic and conscience of society. Teaching in Higher Education, 15(1), 85-96. doi: 10.1080/13562510903487917 Hébert-Losier, K., Newsham-West, R. J., Schneiders, A. G., & Sullivan, S. J. (2009). Raising the standards of the calf-raise test: A systematic review. Journal of Science and Medicine in Sport, 12, 594-602. doi: 10.1016/j.jsams.2008.12.628 Hébert-Losier, K., Schneiders, A. T., Newsham-West, R. J., & Sullivan, S. J. (2009). Scientific bases and clinical utilisation of the calf-raise test. Physical Therapy in Sport, 10(4), 142-149. doi: 10.1016/j.ptsp.2009.07.001 Hegedus, E. J., Cook, C., Fiander, C., & Wright, A. (2010). Measures of arch height and their relationship to pain and dysfunction in people with lower limb impairments. Physiotherapy Research International, 15(3), 160-166. doi: 10.1002/ pri.459 Hendrick, P., Bell, M. L., Bagge, P. J., & Milosavljevic, S. (2009). Can accelerometry be used to discriminate levels of activity? Ergonomics, 52(8), 1019-1025. doi: 10.1080/00140130902846464 Hendrick, P., Bond, C., Duncan, E., & Hale, L. (2009). Clinical reasoning in musculoskeletal practice: Students’ conceptualizations. Physical Therapy, 89(5), 430-442. Hendrick, P., Boyd, T., Low, O., Takarangi, K., Paterson, M., Claydon, L., & Milosavljevic, S. (2010). Construct validity of RT3 accelerometer: A comparison of level-ground and treadmill walking at self-selected speeds. Journal of Rehabilitation Research and Development, 47(2), 157-167. doi: 10.1682/jrrd.2009.04.0047 Hendrick, P., Milosavljevic, S., Bell, M. L., Hale, L., Hurley, D. A., McDonough, S. M., Melloh, M., & Baxter, G. D. (2009). Does physical activity change predict functional recovery in low back pain? Protocol for a prospective cohort study. BMC Musculoskeletal Disorders, 10, 136. doi: 10.1186/1471-2474-10-136 Hendrick, P., Te Wake, A. M., Tikkisetty, A. S., Wulff, L., Yap, C., & Milosavljevic, S. (2010). The effectiveness of walking as an intervention for low back pain: A systematic review. European Spine Journal, Advance Online Publication. doi: 10.1007/ s00586-010-1412-z Ho, C-Y. C., Sole, G., & Munn, J. (2009). The effectiveness of manual therapy in the management of musculoskeletal disorders of the shoulder: A systematic review. Manual Therapy, 14, 463-474. doi: 10.1016/j.math.2009.03.008 Horton, S. J., Johnson, G. M., & Skinner, M. A. (2010). Changes in head and neck posture using an office chair with and without lumbar roll support. Spine, 55(12), E542-E548. doi: 10.1097/BRS.0b013e3181cb8f82 Hutton, L., Frame, R., Maggo, H., Shirakawa, H., Mulligan, H., Waters, D., & Hale, L. (2009). The perceptions of physical activity in an elderly population at risk of falling: A focus group study. New Zealand Journal of Physiotherapy, 37(2), 85-92. Intolo, P., Carman, A. B., Milosavljevic, S., Abbott, J. H., & Baxter, G. D. (2010). The Spineangel®: Examining the validity and reliability of a novel clinical device for monitoring trunk motion. Manual Therapy, 15, 160-166. doi: 10.1016/j. math.2009.10.002

268 RESEARCH REPORT 2009/2010 Intolo, P., Milosavljevic, S., Baxter, D. G., Carman, A. B., Pal, P., & Munn, J. (2009). The effect of age on lumbar range of motion: A systematic review. Manual Therapy, 14(6), 596-604. doi: 10.1016/j.math.2009.08.006 Johnson, G. M., Rosdy, N. M. M., & Horton, S. J. (2010). Manual therapy assessment findings in patients diagnosed with Eagle’s syndrome: A case series. Manual Therapy, Advance Online Publication. doi: 10.1016/j.math.2010.09.007 Johnson, G., & Skinner, M. (2009). The demands of professional opera singing on cranio-cervical posture. European Spine Journal, 18(4), 562-569. doi: 10.1007/s00586-009-0884-1 Kidd, M. O., Bond, C. H., & Bell, M. L. (2010). Patients’ perspectives of patient-centredness as important in musculoskeletal physiotherapy interactions: A qualitative study. Physiotherapy, Advance Online Publication. doi: 10.1016/j. physio.2010.08.002 Latimer, C. P., Keeling, J., Lin, B., Henderson, M., & Hale, L. A. (2010). The impact of bilateral therapy on upper limb function after chronic stroke: A systematic review. Disability and Rehabilitation, 32(15), 1221-1231. doi: 10.3109/09638280903483877 Liddle, S. D., Baxter, G. D., & Gracey, J. H. (2009). Physiotherapists’ use of advice and exercise for the management of chronic low back pain: A national survey. Manual Therapy, 14(2), 189-196. doi: 10.1016/j.math.2008.01.012 Liphardt, A-M., Mündermann, A., Koo, S., Backert, N., Andriacchi, T. P., Zange, J., Mester, J., & Heer, M. (2009). Vibration training intervention to maintain cartilage thickness and serum concentrations of cartilage oligometric matrix protein (COMP) during immobilization. Osteoarthritis and Cartilage, 17(12), 1598-1603. Luxford, B. K., Hale, L., & Piggot, J. (2009). The physiotherapy management of infants with congenital muscular torticollis: A survey of current practice in New Zealand. New Zealand Journal of Physiotherapy, 37(3), 127-135. Mani, R., Milosavljevic, S., & Sullivan, S. J. (2010). The effect of occupational whole-body vibration on standing balance: A systematic review. International Journal of Industrial Ergonomics, Advance Online Publication. doi: 10.1016/j. ergon.2010.05.009 McDonough, S. M., Tully, M. A., O’Connor, S. R., ..., Baxter, D. G., & Hurley, D. A. (2010). The Back 2 Activity Trial: Education and advice versus education and advice plus a structured walking programme for chronic low back pain. BMC Musculoskeletal Disorders, 11, 163. doi: 10.1186/1471-2474-11-163 Meyer, A., Tumilty, S., & Baxter, G. D. (2009). Eccentric exercise protocols for chronic non-insertional Achilles tendinopathy: How much is enough? Scandinavian Journal of Medicine & Science in Sports, 19(5), 609-615. doi: 10.1111/j.1600- 0838.2009.00981.x Milosavljevic, S., Bergman, F., Rehn, B., & Carman, A. B. (2010). All-terrain vehicle use in agriculture: Exposure to whole body vibration and mechanical shock. Applied Ergonomics, 41, 530-535. doi: 10.1016/j.apergo.2009.11.002 Miyahara, M., Butson, R., Cutfield, R., & Clarkson, J. E. (2009). A pilot study of family-focused tele-intervention for children with developmental coordination disorder: Development and lessons learned. Telemedicine Journal and e-Health, 15(7), 707-712. doi: 10.1089/tmj.2009.0022 Mulligan, H., Fjellman-Wiklund, A., Hale, L., Thomas, D., & Häger-Ross, C. (2010). Promoting physical activity for people with neurological disability: Perspectives and experiences of physiotherapists. Physiotherapy Theory and Practice, Advance Online Publication. doi: 10.3109/09593985.2010.519015 Munn, J., Sullivan, S. J., & Schneiders, A. G. (2010). Evidence of sensorimotor deficits in functional ankle instability: A systematic review with meta-analysis. Journal of Science and Medicine in Sport, 13, 2-12. doi: 10.1016/j.jsams.2009.03.004 Mündermann, A., King, K. B., Smith, R. L., & Andriacchi, T. P. (2009). Change in serum COMP concentration due to ambulatory load is not related to knee OA status. Journal of Orthopaedic Research, 27(11), 1408-1413. doi: 10.1002/ jor.20908 Newsham-West, R., Button, C., Milburn, P. D., Mündermann, A., Sole, G., Schneiders, A. G., & Sullivan, S. J. (2009). Training habits and injuries of masters’ level football players: A preliminary report. Physical Therapy in Sport, 10(2), 63-66. doi: 10.1016/j.ptsp.2009.01.002 Newsham-West, R. J., Marley, J., Schneiders, A. G., & Gray, A. (2010). Pre-race health status and medical events during the 2005 World Adventure Racing Championships. Journal of Science and Medicine in Sport, 13(1), 27-31. doi: 10.1016/j. jsams.2008.07.007 Nigg, B. M., Stefanyshyn, D. J., Rozitis, A. I., & Mündermann, A. (2009). Resultant knee joint moments for lateral movement tasks on sliding and non-sliding sport surfaces. Journal of Sports Sciences, 27(5), 427-435. doi: 10.1080/02640410802669161 Oyama, S., Myers, J. B., Wassinger, C. A., & Lephart, S. M. (2010). Three-dimensional scapular and clavicular kinematics and scapular muscle activity during retraction exercises. Journal of Orthopaedic and Sports Physical Therapy, 40(3), 169-179. doi: 10.2519/jospt.2010.3018 Pal, P., Milosavljevic, S., Gregory, D. E., Carman, A. B., & Callaghan, J. P. (2010). The influence of skill and low back pain on trunk postures and low back loads of shearers. Ergonomics, 53(1), 65-73. doi: 10.1080/00140130903389027 Peplow, P. V., Chung, T-Y., & Baxter, G. D. (2010). Laser photobiomodulation of proliferation of cells in culture: A review of human and animal studies. Photomedicine and Laser Surgery, 28(Suppl. 1), S3-S40. doi: 10.1089/pho.2010.2771 Peplow, P. V., Chung, T-Y., & Baxter, G. D. (2010). Laser photobiomodulation of wound healing: A review of experimental studies in mouse and rat animal models. Photomedicine and Laser Surgery, 28(3), 291-325. doi: 10.1089/pho.2008.2446 Perry, M. A., Hendrick, P. A., Hale, L., Baxter, G. D., Milosavljevic, S., Dean, S. G., McDonough, S. M., & Hurley, D. A. (2010). Utility of the RT3 triaxial accelerometer in free living: An investigation of adherence and data loss. Applied Ergonomics, 41, 469-476. doi: 10.1016/j.apergo.2009.10.001 Rishiraj, N., Taunton, J. E., Lloyd-Smith, R., Niven, B., Regan, W., & Woollard, R. (2009). Drop and hop jump GRFs and joint kinematics of braced non-injured subjects: Preliminary study. Minerva Ortopedica e Traumatologica, 60(3), 193-204.

Division of HEALTH SCIENCES 269 Rishiraj, N., Taunton, J. E., Lloyd-Smith, R., Woollard, R., Regan, W., & Clement, D. B. (2009). The potential role of prophylactic/functional knee bracing in preventing knee ligament injury. Sports Medicine, 39(11), 937-960. doi: 10.2165/11317790-000000000-00000 Rishiraj, N., Taunton, J. E., & Niven, B. (2009). Injury profile of elite under-21 age female field hockey players. Journal of Sports Medicine and Physical Fitness, 49(1), 71-77. Schneiders, A. G., Sullivan, S. J., Gray, A. R., Hammond-Tooke, G. D., & McCrory, P. R. (2010). Normative values for three clinical measures of motor performance used in the neurological assessment of sports concussion. Journal of Science and Medicine in Sport, 13(2), 196-201. doi: 10.1016/j.jsams.2009.05.004 Schneiders, A. G., Sullivan, S. J., Kvarnström, J., Olsson, M., Ydén, T., & Marshall, S. (2010). The effect of footwear and sports- surface on dynamic neurological screening for sport-related concussion. Journal of Science and Medicine in Sport, 13, 382- 386. doi: 10.1016/j.jsams.2010.01.003 Schneiders, A. G., Sullivan, S. J., O’Malley, K. J., Clarke, S. V., Knappstein, S. A., & Taylor, L. J. (2010). A valid and reliable clinical determination of footedness. PM&R, 2(9), 835-841. doi: 10.1016/j.pmrj.2010.06.004 Schneiders, A. G., Sullivan, S. J., Rathbone, E. J., Thayer, A. L., Wallis, L. M., & Wilson, A. E. (2010). Visual acuity in young elite motorsport athletes: A preliminary report. Physical Therapy in Sport, 11(2), 47-49. doi: 10.1016/j.ptsp.2010.01.001 Schneiders, A. G., Takemura, M., & Wassinger, C. A. (2009). A prospective epidemiological study of injuries to New Zealand premier club rugby union players. Physical Therapy in Sport, 10(3), 85-90. doi: 10.1016/j.ptsp.2009.05.001 Scudds, R. J., Scudds, R. A., Baxter, G. D., McDonough, S. M., & Walsh, D. M. (2009). Transcutaneous electrical nerve stimulation for the treatment of pain in physiotherapy practices in Hong Kong and the United Kingdom: A survey of usage and perceived effectiveness compared with other pain relieving modalities. Hong Kong Physiotherapy Journal, 27(1), 11-20. doi: 10.1016/S1013-7025(10)70004-X Smith, C., Hale, L., Olson, K., & Schneiders, A. G. (2009). How does exercise influence fatigue in people with multiple sclerosis? Disability and Rehabilitation, 31(9), 685-692. doi: 10.1080/09638280802273473 Smith, J. M., Sullivan, S. J., & Baxter, G. D. (2009). Massage therapy services for healthcare: A telephone focus group study of drivers for clients’ continued use of services. Complementary Therapies in Medicine, 17(5-6), 281-291. doi: 10.1016/j. ctim.2009.07.001 Smith, J. M., Sullivan, S. J., & Baxter, G. D. (2009). Telephone focus groups in physiotherapy research: Potential uses and recommendations. Physiotherapy Theory & Practice, 25(4), 241-256. doi: 10.1080/09593980902782496 Smith, J. M., Sullivan, S. J., & Baxter, G. D. (2009). The culture of massage therapy: Valued elements and the role of comfort, contact, connection and caring. Complementary Therapies in Medicine, 17(4), 181-189. doi: 10.1016/j.ctim.2009.05.003 Sole, C. C., Milosavljevic, S., Sole, G., & Sullivan, S. J. (2010). Exploring a model of asymmetric shoe wear on lower limb performance. Physical Therapy in Sport, 11, 60-65. doi: 10.1016/j.ptsp.2010.02.002 Sullivan, S. J., Bourne, L., Choie, S., Eastwood, B., Isbister, S., McCrory, P., & Gray, A. (2009). Understanding of sport concussion by the parents of young rugby players: A pilot study. Clinical Journal of Sport Medicine, 19(3), 228-230. Tarawhiti, L., Waters, D., Goulding, A., Jones, L., & Hale, L. (2009). Sarcopenic-obesity with polypharmacy is associated with gait and balance disturbances in older adults. New Zealand Medical Student Journal, 9, 19-25. Tumilty, S., Munn, J., Abbott, J. H., McDonough, S., Hurley, D. A., Basford, J. R., & Baxter, G. D. (2010). Laser therapy in the treatment of achilles tendinopathy: A randomised controlled trial. AIP Conference Proceedings, 1226(1), 163-169. doi: 10.1063/1.3453776 Tumilty, S., Munn, J., McDonough, S., Hurley, D. A., Basford, J. R., & Baxter, G. D. (2010). Low level laser treatment of tendinopathy: A systematic review with meta-analysis. Photomedicine and laser surgery, 28(1), 3-16. doi: 10.1089/ pho.2008.2470 Tumilty, S., Munn, J., McDonough, S., Hurley, D. A., Basford, J. R., & Baxter, G. D. (2010). The dose that works: Low level laser treatment of tendinopathy. AIP Conference Proceedings, 1226(1), 170-178. doi: 10.1063/1.3453777 Waters, D. L., Hale, L., Grant, A. M., Herbison, P., & Goulding, A. (2010). Osteoporosis and gait and balance disturbances in older sarcopenic obese New Zealanders. Osteoporosis International, 21(2), 351-357. doi: 10.1007/s00198-009-0947-5 Wright, A. A., Abbott, J. H., Baxter, D., & Cook, C. (2010). The ability of a sustained within-session finding of pain reduction during traction to dictate improved outcomes from a manual therapy approach on patients with osteoarthritis of the hip. Journal of Manual and Manipulative Therapy, 18(3), 166-172. doi: 10.1179/106698110X12640740712536 Wright, A. A., Cook, C., & Abbott, J. H. (2009). Variables associated with the progression of hip osteoarthritis: A systematic review. Arthritis and Rheumatism, 61(7), 925-936. doi: 10.1002/art.24641 Wright, A. A., Cook, C. E., Baxter, G. D., Garcia, J., & Abbott, J. H. (2010). Relationship between the Western Ontario and McMaster Universities Osteoarthritis Index physical function subscale and physical performance measures in patients with hip osteoarthritis. Archives of Physical Medicine and Rehabilitation, 91(10), 1558-1564. doi: 10.1016/j.apmr.2010.07.016 Wright, A. A., Hegedus, E. J., Baxter, G. D., & Abbott, J. H. (2010). Measurement of function in hip osteoarthritis: Developing a standardized approach for physical performance measures. Physiotherapy Theory Practice, Advance Online Publication. doi: 10.3109/09593985.2010.491150

Journal - Research Other Baxter, G. D. (2009). Intra-operative electroacupuncture: Inconclusive findings add nothing new [Commentary]. Focus on Alternative and Complementary Therapies, 14(4), 309-310. doi: 10.1211/fact.14.4.0017 Baxter, G. D. (2009). Laser acupuncture: Effectiveness depends upon dosage [Commentary]. Acupuncture in Medicine, 27(3), 92. doi: 10.1136/aim.2009.000794

270 RESEARCH REPORT 2009/2010 Baxter, G. D. (2009). Potential benefits of laser acupuncture for treatment of headache in children [Commentary]. Focus on Alternative and Complementary Therapies, 14(1), 31-32. doi: 10.1111/j.2042-7166.2009.tb01866.x O’Shea, C., Quick, A., Johnson, G., Carman, A., & Herbison, P. (2010). The effect of a Clark twin block on mandibular motion: A case report. Australian Orthodontic Journal, 26(2), 189-194. Skinner, M. (2009). Strength and endurance exercise endorsed for people with COPD [Invited response]. Physical Therapy Reviews, 14(6), 418. doi: 10.1179/108331909X12540993898017 Smith, J. M., Sullivan, S. J., & Baxter, G. D. (2010). Massage therapy: More than a modality [Invited clinical commentary]. New Zealand Journal of Physiotherapy, 38(2), 44-51. Sole, G., Wright, L., Wassinger, C., Higgs, C., Hansson, M., Johansson, S., & Todd, N. (2010). Reliability of hand-held dynamometric strength testing in people with diabetes/chronic conditions [Invited clinical commentary]. New Zealand Journal of Physiotherapy, 38(2), 52-55.

Journal - Professional & Other Non-Research Articles Becker, I., Woodley, S. J., & Baxter, G. D. (2009). Response to “The beginning of the evidence-based morphology” [Letter to the editor]. Clinical Anatomy, 22(7), 854. doi: 10.1002/ca.20858 Claydon, L. S. (2009). Neuropathic pain: An evidence-based update. New Zealand Journal of Physiotherapy, 37(2), 83-89. Kidd, M. (2010). [Review of the book Clinical education in the health professions]. New Zealand Journal of Physiotherapy, 38(2), 81. Mulligan, H. (2009). [Review of the book Pediatrics for the physical therapist assistant]. New Zealand Journal of Physiotherapy, 37(3), 162.

Working Paper; Discussion Paper; Technical Report Cryer, C., Lovelock, K., Lilley, R., Davidson, P., Davie, G., Samaranayaka, A., McBride, D., Milosavljevic, S., & Morgaine, K. (2009). Effective occupational health interventions in agriculture: Report of a survey of risk factors and exposures on farms [IPRU Report No. ORO76]. Dunedin, New Zealand: Injury Prevention Research Unit, Department of Preventive and Social Medicine, University of Otago. (pp. 1-169). Lilley, R., Cryer, C., Lovelock, K., Davidson, P., McBride, D., Milosavljevic, S., & Morgaine, K. (2009). Effective occupational health interventions in agriculture: An international literature review of primary interventions designed to reduce injury and disease in agriculture [IPRU Report No. ORO75]. Dunedin, New Zealand: Injury Prevention Research Unit, Department of Preventive and Social Medicine, University of Otago. (pp. 1-68).

Division of HEALTH SCIENCES 271 APPENDIX 2 : DIVISIONAL STRUCTURE School of Physiotherapy of Physiology Department School of Pharmacy Deputy Health Sciences Pro-Vice-Chancellor Pharmacology and Toxicology Department of Division Administration Faculty of Dentistry and Department of Microbiology (Health Sciences) Otago School of Otago Medical Sciences and Immunology Pro-Vice-Chancellor Dean, Faculty of Medicine Dean, University of Otago University of Wellington Department Biochemistry University of Otago, University Division of Health Sciences Organisation Structure of Dunedin Anatomy Department School of Medicine Christchurch University of Otago, University

272 RESEARCH REPORT 2009/2010 0800 80 80 98 www.otago.ac.nz txt 866 [email protected]