JPET Fast Forward. Published on November 4, 2010 as DOI: 10.1124/jpet.110.173823 JPET FastThis Forward.article has not Published been copyedited on and November formatted. The 4, final 2010 version as DOI:10.1124/jpet.110.173823may differ from this version. JPET #173823 TITLE PAGE Buprenorphine and opioid antagonism, tolerance, and naltrexone-precipitated withdrawal Carol A. Paronis and Jack Bergman Downloaded from jpet.aspetjournals.org Preclinical Pharmacology Laboratory (C.A.P, J.B.) McLean Hospital/Harvard Medical School Belmont, MA at ASPET Journals on September 26, 2021 Department of Pharmaceutical Sciences (C.A.P.) Northeastern University Boston, MA 1 Copyright 2010 by the American Society for Pharmacology and Experimental Therapeutics. JPET Fast Forward. Published on November 4, 2010 as DOI: 10.1124/jpet.110.173823 This article has not been copyedited and formatted. The final version may differ from this version. JPET #173823 RUNNING TITLE PAGE Running Title: Buprenorphine antagonism, tolerance, and dependence Corresponding author: Carol A. Paronis, PhD Department of Pharmaceutical Sciences Northeastern University Downloaded from 211 Mugar Life Sciences Building Boston, MA 02115 jpet.aspetjournals.org Tel. (617) 373-3212 Fax. (617) 373-8886 Email:
[email protected] at ASPET Journals on September 26, 2021 Number of: Pages - 20 Tables - 3 Figures - 5 References - 38 Number of words in: Abstract - 284 Introduction - 683 Discussion - 1258 2 JPET Fast Forward. Published on November 4, 2010 as DOI: 10.1124/jpet.110.173823 This article has not been copyedited and formatted. The final version may differ from this version. JPET #173823 ABSTRACT The dual antagonist effects of the mixed-action μ-opioid partial agonist/κ-opioid antagonist buprenorphine have not been previously compared in behavioral studies, and it is unknown whether they are comparably modified by chronic exposure.