Common Name: METHYL ISOCYANATE HAZARD SUMMARY IDENTIFICATION REASON for CITATION HOW to DETERMINE IF YOU ARE BEING EXPOSED WORKP

Common Name: METHYL ISOCYANATE

CAS Number: 624-83-9 RTK Substance number: 1270 DOT Number: UN 2480 (PIH) Date: April 1996 Revision: April 2002 ------

HAZARD SUMMARY * Methyl Isocyanate can affect you when breathed in and training concerning chemical hazards and controls. The by passing through your skin. federal OSHA Hazard Communication Standard, 1910.1200, * Methyl Isocyanate may cause mutations. Handle with requires private employers to provide similar training and extreme caution. information to their employees. * Contact can irritate and burn the skin and eyes, and may cause permanent eye damage. * Exposure to hazardous substances should be routinely * Breathing Methyl Isocyanate can irritate the nose and evaluated. This may include collecting personal and area throat. air samples. You can obtain copies of sampling results * Breathing Methyl Isocyanate can irritate the lungs from your employer. You have a legal right to this causing coughing and/or shortness of breath. Higher information under OSHA 1910.1020. exposures can cause a build-up of fluid in the lungs * If you think you are experiencing any work-related health (pulmonary edema), a medical emergency, with severe problems, see a doctor trained to recognize occupational shortness of breath. diseases. Take this Fact Sheet with you. * Methyl Isocyanate may cause an asthma-like allergy. Future exposure can cause asthma attacks with shortness WORKPLACE EXPOSURE LIMITS of breath, wheezing, cough, and/or chest tightness. OSHA: The legal airborne permissible exposure limit * Methyl Isocyanate is a FLAMMABLE and REACTIVE (PEL) is 0.02 ppm averaged over an 8-hour chemical and a FIRE and EXPLOSION HAZARD. workshift. * Methyl Isocyanate is a DOT Poison Inhalation Hazard NIOSH: The recommended airborne exposure limit is (PIH). 0.02 ppm averaged over a 10-hour workshift. * If Methyl Isocyanate is involved in a fire it can release ACGIH: The recommended airborne exposure limit is HYDROGEN CYANIDE. CONSULT THE NEW JERSEY 0.02 ppm averaged over an 8-hour workshift. DEPARTMENT OF HEALTH AND SENIOR SERVICES HAZARDOUS SUBSTANCE FACT SHEET ON * Methyl Isocyanate may cause mutations. All contact with HYDROGEN CYANIDE. this chemical should be reduced to the lowest possible level. IDENTIFICATION * The above exposure limits are for air levels only. When Methyl Isocyanate is a volatile, colorless liquid with a strong, skin contact also occurs, you may be overexposed, even sharp odor that causes tears. It is used in making pesticides, though air levels are less than the limits listed above. polyurethane foams and plastics. WAYS OF REDUCING EXPOSURE REASON FOR CITATION * Where possible, enclose operations and use local exhaust * Methyl Isocyanate is on the Hazardous Substance List ventilation at the site of chemical release. If local exhaust because it is regulated by OSHA and cited by ACGIH, ventilation or enclosure is not used, respirators should be DOT, NIOSH, DEP, HHAG, NFPA and EPA. worn. * This chemical is on the Special Health Hazard Substance * Wear protective work clothing. List because it is FLAMMABLE and REACTIVE. * Wash thoroughly immediately after exposure to Methyl * Definitions are provided on page 5. Isocyanate and at the end of the workshift. * Post hazard and warning information in the work area. In HOW TO DETERMINE IF YOU ARE BEING addition, as part of an ongoing education and training EXPOSED effort, communicate all information on the health and The New Jersey Right to Know Act requires most employers safety hazards of Methyl Isocyanate to potentially to label chemicals in the workplace and requires public exposed workers. employers to provide their employees with information and METHYL ISOCYANATE page 2 of 6

This Fact Sheet is a summary source of information of all Any evaluation should include a careful history of past and potential and most severe health hazards that may result from present symptoms with an exam. Medical tests that look for exposure. Duration of exposure, concentration of the substance damage already done are not a substitute for controlling and other factors will affect your susceptibility to any of the exposure. potential effects described below. ------Request copies of your medical testing. You have a legal right to this information under OSHA 1910.1020. HEALTH HAZARD INFORMATION Mixed Exposures Acute Health Effects * Because smoking can cause heart disease, as well as lung The following acute (short-term) health effects may occur cancer, emphysema, and other respiratory problems, it may immediately or shortly after exposure to Methyl Isocyanate: worsen respiratory conditions caused by chemical exposure. Even if you have smoked for a long time, stopping now will * Contact can irritate and burn the skin and eyes, and may reduce your risk of developing health problems. cause permanent eye damage. * Breathing Methyl Isocyanate can irritate the nose and WORKPLACE CONTROLS AND PRACTICES throat. * Breathing Methyl Isocyanate can irritate the lungs causing Unless a less toxic chemical can be substituted for a hazardous coughing and/or shortness of breath. Higher exposures can substance, ENGINEERING CONTROLS are the most cause a build-up of fluid in the lungs (pulmonary edema), a effective way of reducing exposure. The best protection is to medical emergency, with severe shortness of breath. enclose operations and/or provide local exhaust ventilation at the site of chemical release. Isolating operations can also Chronic Health Effects reduce exposure. Using respirators or protective equipment is The following chronic (long-term) health effects can occur at less effective than the controls mentioned above, but is some time after exposure to Methyl Isocyanate and can last sometimes necessary. for months or years: In evaluating the controls present in your workplace, consider: Cancer Hazard (1) how hazardous the substance is, (2) how much of the * Methyl Isocyanate may cause mutations (genetic changes). substance is released into the workplace and (3) whether Whether or not it poses a cancer or reproductive hazard harmful skin or eye contact could occur. Special controls needs further study. should be in place for highly toxic chemicals or when significant skin, eye, or breathing exposures are possible. Reproductive Hazard * There is an association between exposure to Methyl In addition, the following controls are recommended: Isocyanate and increases in miscarriages among pregnant women. * Where possible, automatically pump liquid Methyl * There is limited evidence that Methyl Isocyanate may Isocyanate from drums or other storage containers to damage the developing fetus. process containers. * There is limited evidence that Methyl Isocyanate may * Before entering a confined space where Methyl Isocyanate decrease fertility in males and females. may be present, check to make sure that an explosive concentration does not exist. Other Long-Term Effects Good WORK PRACTICES can help to reduce hazardous * Methyl Isocyanate may cause an asthma-like allergy. exposures. The following work practices are recommended: Future exposure can cause asthma attacks with shortness of

breath, wheezing, cough, and/or chest tightness. * Workers whose clothing has been contaminated by Methyl * Methyl Isocyanate can irritate the lungs. Repeated Isocyanate should change into clean clothing promptly. exposure may cause bronchitis to develop with cough, * Contaminated work clothes should be laundered by phlegm, and/or shortness of breath. individuals who have been informed of the hazards of

exposure to Methyl Isocyanate. MEDICAL * Eye wash fountains should be provided in the immediate work area for emergency use. Medical Testing * If there is the possibility of skin exposure, emergency If symptoms develop or overexposure is suspected, the shower facilities should be provided. following are recommended: * On skin contact with Methyl Isocyanate, immediately wash or shower to remove the chemical. At the end of the * Lung function tests. These may be normal at first if the workshift, wash any areas of the body that may have person is not having an attack at the time. contacted Methyl Isocyanate, whether or not known skin * Consider chest x-ray after acute overexposure. contact has occurred. METHYL ISOCYANATE page 3 of 6

* Do not eat, smoke, or drink where Methyl Isocyanate is * Exposure to 3 ppm is immediately dangerous to life and handled, processed, or stored, since the chemical can be health. If the possibility of exposure above 3 ppm exists, swallowed. Wash hands carefully before eating, drinking, use a NIOSH approved self-contained breathing apparatus applying cosmetics, smoking, or using the toilet. with a full facepiece operated in a pressure-demand or other positive-pressure mode. PERSONAL PROTECTIVE EQUIPMENT HANDLING AND STORAGE WORKPLACE CONTROLS ARE BETTER THAN PERSONAL PROTECTIVE EQUIPMENT. However, for * Prior to working with Methyl Isocyanate you should be some jobs (such as outside work, confined space entry, jobs trained on its proper handling and storage. done only once in a while, or jobs done while workplace * Methyl Isocyanate must be stored to avoid contact with controls are being installed), personal protective equipment WATER; STRONG ACIDS (such as HYDROCHLORIC, may be appropriate. SULFURIC and NITRIC); ALKALIS; AMINES; IRON; TIN; COPPER; and OXIDIZING AGENTS (such as OSHA 1910.132 requires employers to determine the PERCHLORATES, PEROXIDES, PERMANGANATES, appropriate personal protective equipment for each hazard and CHLORATES, NITRATES, CHLORINE, BROMINE and to train employees on how and when to use protective FLUORINE) since violent reactions occur. equipment. * Store in tightly closed containers in a cool, dry, well-

ventilated area away from HEAT or SUNLIGHT. The following recommendations are only guidelines and may * Sources of ignition, such as smoking and open flames, are not apply to every situation. prohibited where Methyl Isocyanate is used, handled, or

stored. Clothing * Metal containers involving the transfer of Methyl * Avoid skin contact with Methyl Isocyanate. Wear Isocyanate should be grounded and bonded. protective gloves and clothing. Safety equipment * Use only non-sparking tools and equipment, especially suppliers/manufacturers can provide recommendations on when opening and closing containers of Methyl the most protective glove/clothing material for your Isocyanate. operation. * Wherever Methyl Isocyanate is used, handled, * All protective clothing (suits, gloves, footwear, headgear) manufactured, or stored, use explosion-proof electrical should be clean, available each day, and put on before equipment and fittings. work. * ACGIH recommends Butyl rubber, Natural rubber, Neoprene and Viton as protective materials. QUESTIONS AND ANSWERS

Q: If I have acute health effects, will I later get chronic Eye Protection health effects? * Wear indirect-vent, impact and splash resistant goggles A: Not always. Most chronic (long-term) effects result from when working with liquids. repeated exposures to a chemical. * Wear a face shield along with goggles when working with corrosive, highly irritating or toxic substances. Q: Can I get long-term effects without ever having short- * Contact lenses should not be worn when working with this term effects? substance. A: Yes, because long-term effects can occur from repeated exposures to a chemical at levels not high enough to make Respiratory Protection you immediately sick. IMPROPER USE OF RESPIRATORS IS DANGEROUS. Such equipment should only be used if the employer has a Q: What are my chances of getting sick when I have been written program that takes into account workplace conditions, exposed to chemicals? requirements for worker training, respirator fit testing and A: The likelihood of becoming sick from chemicals is medical exams, as described in OSHA 1910.134. increased as the amount of exposure increases. This is * Where the potential exists for exposure over 0.02 ppm, use determined by the length of time and the amount of a NIOSH approved supplied-air respirator with a full material to which someone is exposed. facepiece operated in a pressure-demand or other positive- pressure mode. For increased protection use in combination Q: When are higher exposures more likely? with an auxiliary self-contained breathing apparatus A: Conditions which increase risk of exposure include operated in a pressure-demand or other positive-pressure physical and mechanical processes (heating, pouring, mode. spraying, spills and evaporation from large surface areas such as open containers), and "confined space" exposures (working inside vats, reactors, boilers, small rooms, etc.). METHYL ISOCYANATE page 4 of 6

Q: Is the risk of getting sick higher for workers than for ------community residents? The following information is available from: A: Yes. Exposures in the community, except possibly in cases of fires or spills, are usually much lower than those New Jersey Department of Health and Senior Services found in the workplace. However, people in the Occupational Health Service community may be exposed to contaminated water as PO Box 360 well as to chemicals in the air over long periods. This Trenton, NJ 08625-0360 may be a problem for children or people who are already (609) 984-1863 ill. (609) 984-7407 (fax)

Q: Can men as well as women be affected by chemicals that Web address: http://www.state.nj.us/health/eoh/odisweb/ cause reproductive system damage? A: Yes. Some chemicals reduce potency or fertility in both Industrial Hygiene Information men and women. Some damage sperm and eggs, possibly Industrial hygienists are available to answer your questions leading to birth defects. regarding the control of chemical exposures using exhaust ventilation, special work practices, good housekeeping, good Q: Who is at the greatest risk from reproductive hazards? hygiene practices, and personal protective equipment including A: Pregnant women are at greatest risk from chemicals that respirators. In addition, they can help to interpret the results of harm the developing fetus. However, chemicals may industrial hygiene survey data. affect the ability to have children, so both men and women of childbearing age are at high risk. Medical Evaluation If you think you are becoming sick because of exposure to Q: What are the likely health problems from chemicals which chemicals at your workplace, you may call personnel at the cause mutations? Department of Health and Senior Services, Occupational A: There are two primary health concerns associated with Health Service, who can help you find the information you mutagens: (1) cancers can result from changes induced in need. cells and, (2) adverse reproductive and developmental outcomes can result from damage to the egg and sperm Public Presentations cells. Presentations and educational programs on occupational health or the Right to Know Act can be organized for labor unions, trade associations and other groups.

Right to Know Information Resources The Right to Know Infoline (609) 984-2202 can answer questions about the identity and potential health effects of chemicals, list of educational materials in occupational health, references used to prepare the Fact Sheets, preparation of the Right to Know Survey, education and training programs, labeling requirements, and general information regarding the Right to Know Act. Violations of the law should be reported to (609) 984-2202. ------

METHYL ISOCYANATE page 5 of 6

DEFINITIONS

ACGIH is the American Conference of Governmental NAERG is the North American Emergency Response Industrial Hygienists. It recommends upper limits (called Guidebook. It was jointly developed by Transport Canada, the TLVs) for exposure to workplace chemicals. United States Department of Transportation and the Secretariat of Communications and Transportation of Mexico. It is a A carcinogen is a substance that causes cancer. guide for first responders to quickly identify the specific or generic hazards of material involved in a transportation The CAS number is assigned by the Chemical Abstracts incident, and to protect themselves and the general public Service to identify a specific chemical. during the initial response phase of the incident.

A combustible substance is a solid, liquid or gas that will burn. NCI is the National Cancer Institute, a federal agency that determines the cancer-causing potential of chemicals. A corrosive substance is a gas, liquid or solid that causes irreversible damage to human tissue or containers. NFPA is the National Fire Protection Association. It classifies substances according to their fire and explosion hazard. DEP is the New Jersey Department of Environmental Protection. NIOSH is the National Institute for Occupational Safety and Health. It tests equipment, evaluates and approves respirators, DOT is the Department of Transportation, the federal agency conducts studies of workplace hazards, and proposes standards that regulates the transportation of chemicals. to OSHA.

EPA is the Environmental Protection Agency, the federal NTP is the National Toxicology Program which tests agency responsible for regulating environmental hazards. chemicals and reviews evidence for cancer.

A fetus is an unborn human or animal. OSHA is the Occupational Safety and Health Administration, which adopts and enforces health and safety standards. A flammable substance is a solid, liquid, vapor or gas that will ignite easily and burn rapidly. PEL is the Permissible Exposure Limit which is enforceable by the Occupational Safety and Health Administration. The flash point is the temperature at which a liquid or solid gives off vapor that can form a flammable mixture with air. PIH is a DOT designation for chemicals which are Poison Inhalation Hazards. HHAG is the Human Health Assessment Group of the federal EPA. ppm means parts of a substance per million parts of air. It is a measure of concentration by volume in air. IARC is the International Agency for Research on Cancer, a scientific group that classifies chemicals according to their A reactive substance is a solid, liquid or gas that releases cancer-causing potential. energy under certain conditions.

A miscible substance is a liquid or gas that will evenly dissolve A teratogen is a substance that causes birth defects by in another. damaging the fetus. mg/m3 means milligrams of a chemical in a cubic meter of air. TLV is the Threshold Limit Value, the workplace exposure It is a measure of concentration (weight/volume). limit recommended by ACGIH.

A mutagen is a substance that causes mutations. A mutation is The vapor pressure is a measure of how readily a liquid or a a change in the genetic material in a body cell. Mutations can solid mixes with air at its surface. A higher vapor pressure lead to birth defects, miscarriages, or cancer. indicates a higher concentration of the substance in air and therefore increases the likelihood of breathing it in.

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Common Name: METHYL ISOCYANATE ======DOT Number: UN 2480 (PIH) FOR LARGE SPILLS AND FIRES immediately call your fire NAERG Code: 155 department. You can request emergency information from the CAS Number: 624-83-9 following:

CHEMTREC: (800) 424-9300 Hazard rating NJDHSS NFPA NJDEP HOTLINE: 1-877-WARN-DEP FLAMMABILITY - 3 ======HANDLING AND STORAGE (See page 3) - 2 REACTIVITY FLAMMABLE AND REACTIVE FIRST AID POISON INHALATION HAZARD For POISON INFORMATION call 1-800-222-1222 DO NOT USE WATER POISONOUS GASES ARE PRODUCED IN FIRE Eye Contact CONTAINERS MAY EXPLODE IN FIRE * Immediately flush with large amounts of water. Continue for at least 30 minutes. Seek medical attention. Hazard Rating Key: 0=minimal; 1=slight; 2=moderate; 3=serious; 4=severe Skin Contact * Quickly remove contaminated clothing. Wash area with FIRE HAZARDS large amounts of soap and water. Seek medical attention. * Methyl Isocyanate is a FLAMMABLE LIQUID. * Use dry chemical or CO2 extinguishers. Breathing * DO NOT USE WATER. * Remove the person from exposure. * POISONOUS GASES ARE PRODUCED IN FIRE, * Begin rescue breathing (using universal precautions) if including Hydrogen Cyanide and Nitrogen Oxides. breathing has stopped and CPR if heart action has stopped. * CONTAINERS MAY EXPLODE IN FIRE. * Transfer promptly to a medical facility. * Vapors may travel to a source of ignition and flash back. * Medical observation is recommended for 24 to 48 hours * Vapor is heavier than air and may travel a distance to cause after breathing overexposure, as pulmonary edema may be a fire or explosion far from the source. delayed. * If employees are expected to fight fires, they must be trained and equipped as stated in OSHA 1910.156. Antidotes and Special Procedures * Use Amyl Nitrite capsules if symptoms develop. All area SPILLS AND EMERGENCIES employees should be trained regularly in emergency If Methyl Isocyanate is spilled or leaked, take the following treatment of Cyanide poisoning and in CPR. A Cyanide steps: antidote kit MUST be rapidly available and ingredients replaced every 1 to 2 years to ensure freshness. * Evacuate persons not wearing protective equipment from area of spill or leak until clean-up is complete. PHYSICAL DATA * Remove all ignition sources. Vapor Pressure: 348 mm Hg at 68oF (20oC) * Absorb liquids in vermiculite, dry sand, earth, or a similar o o material and deposit in sealed containers. Flash Point: 19 F (-7 C) * Ventilate area after clean-up is complete. Water Solubility: Reactive * DO NOT USE WATER OR WET METHOD. * Keep Methyl Isocyanate out of a confined space, such as a OTHER COMMONLY USED NAMES sewer, because of the possibility of an explosion, unless the Chemical Name: sewer is designed to prevent the build-up of explosive Methane, Isocyanato- concentrations. Other Names: * It may be necessary to contain and dispose of Methyl MIC; Isocyanic Acid, Methyl Ester; Methylcarbamyl Amine Isocyanate as a HAZARDOUS WASTE. Contact your ------state Department of Environmental Protection (DEP) or Not intended to be copied and sold for commercial your regional office of the federal Environmental purposes. Protection Agency (EPA) for specific recommendations. ------* If employees are required to clean-up spills, they must be NEW JERSEY DEPARTMENT OF HEALTH AND properly trained and equipped. OSHA 1910.120(q) may be SENIOR SERVICES applicable. Right to Know Program PO Box 368, Trenton, NJ 08625-0368 (609) 984-2202 H5027 ------