Supplemental Table 3. Individual Drug Predictions by CMAP Analysis
Supplemental Table 3. Individual drug predictions by CMAP analysis.
Correlationc
Drug Familya Drug Degreeb 595 638 589
Proteasome inhibitors and UPS disulfiram ++ + + + modulators
MG-262 +++ np + +
mometasone ++ np + +
NFκB inhibitors 15-delta prostaglandin J2 ++ + + +
thiostrepton ++ + + np
parthenolide ++ + + np
withaferin A ++ + + +
HSP90 inhibitors geldanamycin ++ + + np
alvespimycin ++ + np +
monorden + + np +
tanespimycin + + np np
Protein synthesis inhibitors puromycin +++ + + +
anisomycin +++ np + +
emetine ++ np + +
cephaeline +++ np + +
cicloheximide ++ + + +
CDK/TopoI/TopoII/Cell cycle doxorubicin – – – np - - inhibitors
resveratrol ++ + np np
camptothecin – – – np - np
ellipticine – – np - np etoposide – – np - np
mitoxantrone – – np - np
harmine – – np np -
luteolin – – np np -
staurosporine – np np -
Sodium/calcium modulators and tetrandrine + + + + calcium channel blockers
gossypol ++ + + +
econazole ++ + + np
perhexiline ++ + + np
clomifene ++ + + np
bepridil ++ + + np
felodipine + np + +
nitrendipine – – - np np
cyproheptadine ++ + np np
Na+/K+ - ATPase membrane helveticoside ++ np + + pump inhibitors
lanatoside C ++ np + +
digoxin ++ np + +
digitoxigenin ++ np + +
digoxigenin + np np +
strophanthidin + np np +
ouabain + np np +
Antihistamines and terfenadine +++ + + +
Anticholinergics astemizole ++ + + np
proadifen ++ + np +
spiperone ++ np + +
atropine – – np np -
mefloquine ++ + np +
clemastine ++ np + np
Microtubule inhibitors mebendazole ++ + + np
nocodazole ++ + np +
fenbendazole ++ + + np
Alkylating agents semustine ++ + + +
lomustine ++ + + np
PI3K inhibitors LY-294002 ++ + np np
HDAC inhibitors trichostatin A ++ + np np
vorinostat ++ + np np
rifabutin ++ + np np
scriptaid ++ + np np
valproic acid ++ + np np
Antipsychotics thioridazine ++ + + np
prochlorperazine ++ + + np
pimozide ++ + + np
fluphenazine ++ + + np
metergoline ++ + np np
chlorcyclizine + + + np
trifluoperazine ++ + + np
metixene ++ np np + cloperastine ++ + np np
perphenazine ++ + np np
thioproperazine ++ + np np
Antidepressants desipramine ++ + + np
doxepin ++ + np np
norcyclobenzaprine ++ + np np
imipramine ++ + np np
Antivirals mycophenolic acid – – np - -
methotrexate – np - np
aDrugs families determined from previous literature (1). bIndicates the degree to which a drug is positively or negatively correlated (by correlation score output from CMAP) calculated as the average correlation score across the 3 lines where: |0-
0.33| = +/-; |0.34-0.66| = ++/--; |0.67-1| = +++/---. cOutput given by CMAP indicating the relatedness of the input profile to the database profile where “–“ is a strong opposite response and “+” is a strong similar response by gene expression profiling. “np” indicates that no prediction was made for this drug in this cell line. All prediction were significant with a p < 0.05.
Reference
1. Iorio F, Bosotti R, Scacheri E, Belcastro V, Mithbaokar P, Ferriero R, et al. Discovery of drug mode of action and drug repositioning from transcriptional responses. Proceedings of the National Academy of Sciences of the United States of America. 2010;107:14621-6.