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(12) Patent Application Publication (10) Pub. No.: US 2006/0110428A1 De Juan Et Al
US 200601 10428A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2006/0110428A1 de Juan et al. (43) Pub. Date: May 25, 2006 (54) METHODS AND DEVICES FOR THE Publication Classification TREATMENT OF OCULAR CONDITIONS (51) Int. Cl. (76) Inventors: Eugene de Juan, LaCanada, CA (US); A6F 2/00 (2006.01) Signe E. Varner, Los Angeles, CA (52) U.S. Cl. .............................................................. 424/427 (US); Laurie R. Lawin, New Brighton, MN (US) (57) ABSTRACT Correspondence Address: Featured is a method for instilling one or more bioactive SCOTT PRIBNOW agents into ocular tissue within an eye of a patient for the Kagan Binder, PLLC treatment of an ocular condition, the method comprising Suite 200 concurrently using at least two of the following bioactive 221 Main Street North agent delivery methods (A)-(C): Stillwater, MN 55082 (US) (A) implanting a Sustained release delivery device com (21) Appl. No.: 11/175,850 prising one or more bioactive agents in a posterior region of the eye so that it delivers the one or more (22) Filed: Jul. 5, 2005 bioactive agents into the vitreous humor of the eye; (B) instilling (e.g., injecting or implanting) one or more Related U.S. Application Data bioactive agents Subretinally; and (60) Provisional application No. 60/585,236, filed on Jul. (C) instilling (e.g., injecting or delivering by ocular ion 2, 2004. Provisional application No. 60/669,701, filed tophoresis) one or more bioactive agents into the Vit on Apr. 8, 2005. reous humor of the eye. Patent Application Publication May 25, 2006 Sheet 1 of 22 US 2006/0110428A1 R 2 2 C.6 Fig. -
General Anesthetic Actions on GABAA Receptors Paul Garcia, Emory University Scott E
General Anesthetic Actions on GABAA Receptors Paul Garcia, Emory University Scott E. Kolesky, Emory University Andrew Jenkins, Emory University Journal Title: Current Neuropharmacology Volume: Volume 8, Number 1 Publisher: Bentham Science Publishers | 2010-03, Pages 2-9 Type of Work: Article | Final Publisher PDF Publisher DOI: 10.2174/157015910790909502 Permanent URL: http://pid.emory.edu/ark:/25593/fkg4m Final published version: http://www.eurekaselect.com/71259/article Copyright information: ©2010 Bentham Science Publishers Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution 2.5 Generic License ( http://creativecommons.org/licenses/by/2.5/), which permits distribution, public display, and publicly performance, distribution of derivative works, making multiple copies, provided the original work is properly cited. This license requires credit be given to copyright holder and/or author. Accessed September 28, 2021 5:01 PM EDT 2 Current Neuropharmacology, 2010, 8, 2-9 General Anesthetic Actions on GABAA Receptors Paul S. Garcia, Scott E. Kolesky and Andrew Jenkins* Departments of Anesthesiology and Pharmacology, Emory University, School of Medicine, Rollins Research Center #5013, 1510 Clifton Rd NE, Atlanta GA, USA Abstract: General anesthetic drugs interact with many receptors in the nervous system, but only a handful of these inter- actions are critical for producing anesthesia. Over the last 20 years, neuropharmacologists have revealed that one of the most important target sites for general -
(12) United States Patent (10) Patent No.: US 6,264,917 B1 Klaveness Et Al
USOO6264,917B1 (12) United States Patent (10) Patent No.: US 6,264,917 B1 Klaveness et al. (45) Date of Patent: Jul. 24, 2001 (54) TARGETED ULTRASOUND CONTRAST 5,733,572 3/1998 Unger et al.. AGENTS 5,780,010 7/1998 Lanza et al. 5,846,517 12/1998 Unger .................................. 424/9.52 (75) Inventors: Jo Klaveness; Pál Rongved; Dagfinn 5,849,727 12/1998 Porter et al. ......................... 514/156 Lovhaug, all of Oslo (NO) 5,910,300 6/1999 Tournier et al. .................... 424/9.34 FOREIGN PATENT DOCUMENTS (73) Assignee: Nycomed Imaging AS, Oslo (NO) 2 145 SOS 4/1994 (CA). (*) Notice: Subject to any disclaimer, the term of this 19 626 530 1/1998 (DE). patent is extended or adjusted under 35 O 727 225 8/1996 (EP). U.S.C. 154(b) by 0 days. WO91/15244 10/1991 (WO). WO 93/20802 10/1993 (WO). WO 94/07539 4/1994 (WO). (21) Appl. No.: 08/958,993 WO 94/28873 12/1994 (WO). WO 94/28874 12/1994 (WO). (22) Filed: Oct. 28, 1997 WO95/03356 2/1995 (WO). WO95/03357 2/1995 (WO). Related U.S. Application Data WO95/07072 3/1995 (WO). (60) Provisional application No. 60/049.264, filed on Jun. 7, WO95/15118 6/1995 (WO). 1997, provisional application No. 60/049,265, filed on Jun. WO 96/39149 12/1996 (WO). 7, 1997, and provisional application No. 60/049.268, filed WO 96/40277 12/1996 (WO). on Jun. 7, 1997. WO 96/40285 12/1996 (WO). (30) Foreign Application Priority Data WO 96/41647 12/1996 (WO). -
Pharmaceutical Appendix to the Tariff Schedule 2
Harmonized Tariff Schedule of the United States (2007) (Rev. 2) Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE Harmonized Tariff Schedule of the United States (2007) (Rev. 2) Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 2 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. ABACAVIR 136470-78-5 ACIDUM LIDADRONICUM 63132-38-7 ABAFUNGIN 129639-79-8 ACIDUM SALCAPROZICUM 183990-46-7 ABAMECTIN 65195-55-3 ACIDUM SALCLOBUZICUM 387825-03-8 ABANOQUIL 90402-40-7 ACIFRAN 72420-38-3 ABAPERIDONUM 183849-43-6 ACIPIMOX 51037-30-0 ABARELIX 183552-38-7 ACITAZANOLAST 114607-46-4 ABATACEPTUM 332348-12-6 ACITEMATE 101197-99-3 ABCIXIMAB 143653-53-6 ACITRETIN 55079-83-9 ABECARNIL 111841-85-1 ACIVICIN 42228-92-2 ABETIMUSUM 167362-48-3 ACLANTATE 39633-62-0 ABIRATERONE 154229-19-3 ACLARUBICIN 57576-44-0 ABITESARTAN 137882-98-5 ACLATONIUM NAPADISILATE 55077-30-0 ABLUKAST 96566-25-5 ACODAZOLE 79152-85-5 ABRINEURINUM 178535-93-8 ACOLBIFENUM 182167-02-8 ABUNIDAZOLE 91017-58-2 ACONIAZIDE 13410-86-1 ACADESINE 2627-69-2 ACOTIAMIDUM 185106-16-5 ACAMPROSATE 77337-76-9 -
Marrakesh Agreement Establishing the World Trade Organization
No. 31874 Multilateral Marrakesh Agreement establishing the World Trade Organ ization (with final act, annexes and protocol). Concluded at Marrakesh on 15 April 1994 Authentic texts: English, French and Spanish. Registered by the Director-General of the World Trade Organization, acting on behalf of the Parties, on 1 June 1995. Multilat ral Accord de Marrakech instituant l©Organisation mondiale du commerce (avec acte final, annexes et protocole). Conclu Marrakech le 15 avril 1994 Textes authentiques : anglais, français et espagnol. Enregistré par le Directeur général de l'Organisation mondiale du com merce, agissant au nom des Parties, le 1er juin 1995. Vol. 1867, 1-31874 4_________United Nations — Treaty Series • Nations Unies — Recueil des Traités 1995 Table of contents Table des matières Indice [Volume 1867] FINAL ACT EMBODYING THE RESULTS OF THE URUGUAY ROUND OF MULTILATERAL TRADE NEGOTIATIONS ACTE FINAL REPRENANT LES RESULTATS DES NEGOCIATIONS COMMERCIALES MULTILATERALES DU CYCLE D©URUGUAY ACTA FINAL EN QUE SE INCORPOR N LOS RESULTADOS DE LA RONDA URUGUAY DE NEGOCIACIONES COMERCIALES MULTILATERALES SIGNATURES - SIGNATURES - FIRMAS MINISTERIAL DECISIONS, DECLARATIONS AND UNDERSTANDING DECISIONS, DECLARATIONS ET MEMORANDUM D©ACCORD MINISTERIELS DECISIONES, DECLARACIONES Y ENTEND MIENTO MINISTERIALES MARRAKESH AGREEMENT ESTABLISHING THE WORLD TRADE ORGANIZATION ACCORD DE MARRAKECH INSTITUANT L©ORGANISATION MONDIALE DU COMMERCE ACUERDO DE MARRAKECH POR EL QUE SE ESTABLECE LA ORGANIZACI N MUND1AL DEL COMERCIO ANNEX 1 ANNEXE 1 ANEXO 1 ANNEX -
Environmentally Acceptable Flame Extinguishants
ENVIRONMENTALLY ACCEPTABLE FLAME EXTINGUISHANTS J. Douglas Mather, Ph. D. Robert E. Tapscott, Ph.D., Chemical Development Studies, Inc. GlobeTech, Inc. 7636 William Moyers Ave. NE 8200 Montgomery Blvd. NE, #218 Albuquerque, NM 87122 Albuquerque, NM 87109 505-797-9706 505-883-9399 [email protected] [email protected] INTRODUCTION Research geared to the identification and testing of environmentally friendly extinguishants – specifically compounds with low boiling points suitable for use in cold environments - is sponsored by the National Institute of Standards and Technology and the Next Generation Fire Suppression Technology Program. Low temperature conditions are a characteristic of aircraft in-flight at higher altitudes. Fire suppression agents with lower boiling points are expected to disperse more rapidly and uniformly than higher boiling agents. A broad review of chemical families identified many with potential to meet the restrictive list of requirements for a suitable halon replacement. This subsequent chemical selection effort builds on several prior projects and guidance from in depth assessment of a wide range of chemical families [1, 2., 3, 4, 5, 6] Chemical families examined as potential sources of halon 1301 alternatives covered a broad range of elements, chemical functionalities. Information relating to environmental persistence, toxicity, flame suppression, reactivity and a number of other factors were considered. The resulting list of chemical families presented as being worthy of continued or initial consideration ranged from brominated carbon based compounds to metal containing compounds. The current focus on low boiling compounds eliminated many of theses down-selected chemical families. The remaining chemical families were reexamined and the higher boiling members eliminated from further consideration. -
De Fármacos Antimaláricos
Facultad de Química-Farmacia Centro de Bioactivos Químicos TOMOCOMD-CARDD: Un Novedoso Enfoque para el Diseño ‘Racional In- Silico’ de Fármacos Antimaláricos Tesis presentada en opción al grado de Licenciado en Ciencias Farmacéuticas. Autor: Carlos Ricardo Romero Zaldivar Tutores: Prof. Inst., Lic. Yovani Marrero Ponce, M.Sc. Prof. Asist., Lic. Maité Iyarreta Veitía, Ph.D. Santa Clara 2004 RESUMEN Nuevos descriptores moleculares útiles para el diseño “racional in silico” de fármacos han sido aplicados a la modelación de la actividad antimalárica. El cálculo de los nuevos índices moleculares fue implementado en el programa TOMOCOMD-CARDD (TOpological MOlecular COMputer Design-Computed Aided ‘Rational’ Drug Design). Los índices cuadráticos y lineales (estocásticos y no estocásticos) fueron usados junto con el análisis discriminante lineal (ADL) para desarrollar modelos QSAR-ADL que permitan la correcta predicción de la actividad antimalárica. Los modelos obtenidos describen adecuadamente la actividad biológica estudiada y en todos los casos clasifican correctamente más del 90.00% de los compuestos en la serie de entrenamiento. En orden de acceder a la robustez y al poder predictivo de los modelos encontrados, procedimientos de validación cruzada interna y externa fueron utilizados. Estas aproximaciones permiten obtener una adecuada explicación de la actividad antimalárica basado en rasgos estructurales evidenciando el rol preponderante de los enlaces de hidrógenos, la presencia de heteroátomos y de las propiedades relacionadas con el tamaño molecular en las interacciones con los sitios dianas antimaláricos. Posteriormente, los modelos desarrollados fueron usados en la simulación de una búsqueda virtual de inhibidores de la farnesil-transferasa (H-Ras) con actividad antimalárica; 84.61% de los inhibidores de la H-Ras usados en esta búsqueda virtual fueron correctamente clasificados por las modelos QSAR-ADL, indicando la habilidad del método TOMOCOMD-CARDD para el descubrimiento de nuevos compuestos líderes con nuevos mecanismos de acción. -
Customs Tariff - Schedule
CUSTOMS TARIFF - SCHEDULE 99 - i Chapter 99 SPECIAL CLASSIFICATION PROVISIONS - COMMERCIAL Notes. 1. The provisions of this Chapter are not subject to the rule of specificity in General Interpretative Rule 3 (a). 2. Goods which may be classified under the provisions of Chapter 99, if also eligible for classification under the provisions of Chapter 98, shall be classified in Chapter 98. 3. Goods may be classified under a tariff item in this Chapter and be entitled to the Most-Favoured-Nation Tariff or a preferential tariff rate of customs duty under this Chapter that applies to those goods according to the tariff treatment applicable to their country of origin only after classification under a tariff item in Chapters 1 to 97 has been determined and the conditions of any Chapter 99 provision and any applicable regulations or orders in relation thereto have been met. 4. The words and expressions used in this Chapter have the same meaning as in Chapters 1 to 97. Issued January 1, 2019 99 - 1 CUSTOMS TARIFF - SCHEDULE Tariff Unit of MFN Applicable SS Description of Goods Item Meas. Tariff Preferential Tariffs 9901.00.00 Articles and materials for use in the manufacture or repair of the Free CCCT, LDCT, GPT, UST, following to be employed in commercial fishing or the commercial MT, MUST, CIAT, CT, harvesting of marine plants: CRT, IT, NT, SLT, PT, COLT, JT, PAT, HNT, Artificial bait; KRT, CEUT, UAT, CPTPT: Free Carapace measures; Cordage, fishing lines (including marlines), rope and twine, of a circumference not exceeding 38 mm; Devices for keeping nets open; Fish hooks; Fishing nets and netting; Jiggers; Line floats; Lobster traps; Lures; Marker buoys of any material excluding wood; Net floats; Scallop drag nets; Spat collectors and collector holders; Swivels. -
Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DIX to the HTSUS—Continued
20558 Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DEPARMENT OF THE TREASURY Services, U.S. Customs Service, 1301 TABLE 1.ÐPHARMACEUTICAL APPEN- Constitution Avenue NW, Washington, DIX TO THE HTSUSÐContinued Customs Service D.C. 20229 at (202) 927±1060. CAS No. Pharmaceutical [T.D. 95±33] Dated: April 14, 1995. 52±78±8 ..................... NORETHANDROLONE. A. W. Tennant, 52±86±8 ..................... HALOPERIDOL. Pharmaceutical Tables 1 and 3 of the Director, Office of Laboratories and Scientific 52±88±0 ..................... ATROPINE METHONITRATE. HTSUS 52±90±4 ..................... CYSTEINE. Services. 53±03±2 ..................... PREDNISONE. 53±06±5 ..................... CORTISONE. AGENCY: Customs Service, Department TABLE 1.ÐPHARMACEUTICAL 53±10±1 ..................... HYDROXYDIONE SODIUM SUCCI- of the Treasury. NATE. APPENDIX TO THE HTSUS 53±16±7 ..................... ESTRONE. ACTION: Listing of the products found in 53±18±9 ..................... BIETASERPINE. Table 1 and Table 3 of the CAS No. Pharmaceutical 53±19±0 ..................... MITOTANE. 53±31±6 ..................... MEDIBAZINE. Pharmaceutical Appendix to the N/A ............................. ACTAGARDIN. 53±33±8 ..................... PARAMETHASONE. Harmonized Tariff Schedule of the N/A ............................. ARDACIN. 53±34±9 ..................... FLUPREDNISOLONE. N/A ............................. BICIROMAB. 53±39±4 ..................... OXANDROLONE. United States of America in Chemical N/A ............................. CELUCLORAL. 53±43±0 -
Comparative Toxicity of Isoflurane, Halothane, Fluroxene and Diethyl Ether in Human Volunteers
COMPARATIVE TOXICITY OF ISOFLURANE, HALOTHANE, FLUROXENE AND DIETHYL ETHER IN HUMAN VOLUNTEERS WENDELL C. STEVENS, M.D., E.I. ECEn, u, M.D., THOMAS A. JoAs, M.D., THOMAS H. CnOMWELL, M.D., ANNE WHITE, M.A., AND WILLIAM M. DOLAN, M.D. INTRODUCTION ALTHOUC~ SEVEnAL STUDIES have examined the hepatorenal iniury that may occur in man following exposure to anaesthetic drugs, most are tainted by the presence of other medications, the concomitant stress imposed by the operation or the prior existence of hepatic or renal disease. Other studies have failed to measure anaes- thetic dose (alveolar or arterial concentrations) and the duration of anaesthetic exposure, although such measurements are necessary to quantitate the imposed time-dose stress. During our studies of the effects of various anaesthetics on cardiorespiratory function 1-7 we also evaluated the effects of these anaesthetics on subsequent hepatic and renal function. These measurements were made in healthy, young human volunteers and were uncomplicated by prior medication or concomitant operation. Anaesthesia was prolonged and at times profound. We present the results of the hepatic, renal and haematological studies in the following report. The findings suggest that small but significant differences exist among anaesthetics in their abilities to produce adverse effects. However, the changes seen were minimal, even with those agents which caused abnormalities. METHODS Many of the details of the methods used in this study have been described previously and only additions or deviations from prior protocols will be noted. 1-7 Briefly, studies were made on healthy volunteers between 21 and 30 years of age. -
Caenorhabditis Elegans (Genetics/Mutations/Anesthesia) PHIL G
Proc. Natl. Acad. Sci. USA Vol. 87, pp. 2%5-2969, April 1990 Medical Sciences Multiple sites of action of volatile anesthetics in Caenorhabditis elegans (genetics/mutations/anesthesia) PHIL G. MORGAN*t, MARGARET SEDENSKY*, AND PHILIP M. MENEELY* *Department of Anesthesiology, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH 44106; tFred Hutchinson Cancer Research Center, Seattle, WA 98104 Communicated by Harold Weintraub, January 22, 1990 (receivedfor review November 2, 1989) ABSTRACT The mechanism and site(s) of action of vola- low doses of anesthetic the animals become "excited," tile anesthetics are unknown. In all organisms studied, volatile moving more than animals not exposed to anesthetics. As the anesthetics adhere to the Meyer-Overton relationship-that anesthetic concentrations are increased, the animals next is, a in-n plot of the oil-gas partition coefficients versus the become very uncoordinated, and at higher doses they are potencies yields a straight line with a slope of -1. This immobilized. When removed from the anesthetics the nem- relationship has led to two conclusions about the site of action atodes quickly regain mobility and return to their normal of volatile anesthetics. (i) It has properties similar to the lipid phenotype. Mutations in two genes, unc-79 and unc-80, used to determine the oil-gas partition coefficients. (a) All confer altered responses to volatile anesthetics, in addition to volatile anesthetics cause anesthesia by affecting a single site. In an altered motor phenotype. When not in the presence of Caenorhabditis elegans, we have identified two mutants with anesthetics, both these mutants are described as "fainters." altered sensitivities to only some volatile anesthetics. -
Author Index
Author Index The numbers shown in square brackets are the numbers of the references in the bibliography. Page numbers in italiC<J refer to the bibliography" Abajian, J., Jr., Brazell, E. Ahlgren, I., Aronsen, K. F. Allaria, R, Galligari, G., H., Dente, G. A., Mills, 181,228 Bottani, G., Castelli, S. E. L. 306, 320 -- Ericsson, B., Fajgelj, 174, 176, 202, 203, 228 - see Mazuzan, J. E. 169, A. 181,228 Allen, C. R., see Walker, J. 171,235 - see Belfrage, S. 58, 66 A. 166, 172, 175, 177, - see Shinozaki, T. 36,51, Ahlgren, L., see Belfrage, S. 201, 204, 206, 207, 240 75, 169, 172, 175, 176, 512,526 - see Wilson, R. D. 112, 177,238 Ahlmark, A., Forssman, S. 122 Abbott 77 350,354 Allen, G. D., Ward, R. J., Abbott, B. C., Mommaerts, Aikawa, J. K., see Virtue, Perrin, E. R 46, 66 W. F. H. M. 228 R. W. 247,253 - see Ward, R. J. 240 Abboud, F. M., see Caffrey, Akester, J. M., Brody, M. J. Allen, J. G., see Adams, W. J. A. 53,67,184,230 183,228 F. 492,499 Abel, F. L., Waldhausen, J. Albers, C., Brendel, W., Allison, A. C., Nunn, J. F. A. 118 Usinger, W. 281,284 63,66 - see Sutherland, A. 160, Albert, S. N., Jain, R. C., Allweis, C., Magnes, J. 239 Shadid, .J. N. 200, 228 394,395,404 Abere, J. F., see Bovey, F. Albin, M. S., Horrocks, L. - see Barkai, A. 395, 404 20, 30 A., Kretchmer, E. 12,.30 Allweis, C.