Systemic Analysis of PPARγ in Mouse Macrophage Populations Reveals Marked Diversity in Expression with Critical Roles in Resolution of Inflammation and Airway This information is current as Immunity of September 29, 2021. Emmanuel L. Gautier, Andrew Chow, Rainer Spanbroek, Genevieve Marcelin, Melanie Greter, Claudia Jakubzick, Milena Bogunovic, Marylene Leboeuf, Nico van Rooijen,

Andreas J. Habenicht, Miriam Merad and Gwendalyn J. Downloaded from Randolph J Immunol 2012; 189:2614-2624; Prepublished online 1 August 2012; doi: 10.4049/jimmunol.1200495

http://www.jimmunol.org/content/189/5/2614 http://www.jimmunol.org/

Supplementary http://www.jimmunol.org/content/suppl/2012/08/01/jimmunol.120049 Material 5.DC1 References This article cites 48 articles, 15 of which you can access for free at:

http://www.jimmunol.org/content/189/5/2614.full#ref-list-1 by guest on September 29, 2021

Why The JI? Submit online.

• Rapid Reviews! 30 days* from submission to initial decision

• No Triage! Every submission reviewed by practicing scientists

• Fast Publication! 4 weeks from acceptance to publication

*average

Subscription Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription Permissions Submit copyright permission requests at: http://www.aai.org/About/Publications/JI/copyright.html Email Alerts Receive free email-alerts when new articles cite this article. Sign up at: http://jimmunol.org/alerts

The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 Copyright © 2012 by The American Association of Immunologists, Inc. All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. The Journal of Immunology

Systemic Analysis of PPARg in Mouse Macrophage Populations Reveals Marked Diversity in Expression with Critical Roles in Resolution of Inflammation and Airway Immunity

Emmanuel L. Gautier,*,†,‡ Andrew Chow,†,x Rainer Spanbroek,{ Genevieve Marcelin,‖ Melanie Greter,†,x Claudia Jakubzick,*,†,1 Milena Bogunovic,†,x Marylene Leboeuf,†,x Nico van Rooijen,# Andreas J. Habenicht,{ Miriam Merad,†,x and Gwendalyn J. Randolph*,†,‡

Although peroxisome proliferator-activated receptor g (PPARg) has anti-inflammatory actions in macrophages, which macro- Downloaded from phage populations express PPARg in vivo and how it regulates tissue homeostasis in the steady state and during inflammation remains unclear. We now show that lung and spleen macrophages selectively expressed PPARg among resting tissue macrophages. In addition, Ly-6Chi monocytes recruited to an inflammatory site induced PPARg as they differentiated to macrophages. When PPARg was absent in Ly-6Chi–derived inflammatory macrophages, initiation of the inflammatory response was unaffected, but full resolution of inflammation failed, leading to chronic leukocyte recruitment. Conversely, PPARg activation favored resolution of inflammation in a macrophage PPARg-dependent manner. In the steady state, PPARg deficiency in red pulp macrophages did http://www.jimmunol.org/ not induce overt inflammation in the spleen. By contrast, PPARg deletion in lung macrophages induced mild pulmonary inflam- mation at the steady state and surprisingly precipitated mortality upon infection with Streptococcus pneumoniae. This accelerated mortality was associated with impaired bacterial clearance and inability to sustain macrophages locally. Overall, we uncovered critical roles for macrophage PPARg in promoting resolution of inflammation and maintaining functionality in lung macrophages where it plays a pivotal role in supporting pulmonary host defense. In addition, this work identifies specific macrophage pop- ulations as potential targets for the anti-inflammatory actions of PPARg agonists. The Journal of Immunology, 2012, 189: 2614– 2624. by guest on September 29, 2021 eroxisome proliferator-activated receptor g (PPARg)is nedione family, the latter being used clinically to improve insulin a ligand-controlled transcription factor of the nuclear re- sensitivity in type 2 diabetic patients (3). P ceptor family capable of regulating gene expression by The anti-inflammatory role of PPARg came to the forefront in transactivation or transrepression (1). First discovered as the master the late 1990s when 15-deoxy-d-12,14-PG J2 (15d-PGJ2) and thia- regulator of the genetic program supporting adipocyte differenti- zolidinediones were shown to dampen macrophage activation ation, PPARg is involved in the regulation of a number of phys- in vitro by activating PPARg (4, 5). Since then, the anti-inflammatory iological processes such as the response to insulin, cell proliferation, role of PPARg agonists has been extensively documented in vitro cellular lipid metabolism, and inflammation (2). Thus, PPARg and in vivo (1, 6). Indeed, PPARg agonists suppress dextran so- activation is an attractive therapeutic target in a variety of diseases dium sulfate-induced colitis (7), obesity-induced insulin resistance such as type 2 diabetes, cancer, atherosclerosis, and immune (8), and the progression of atherosclerosis (9). By contrast, dele- disorders. Activation of PPARg can be achieved by natural fatty tion of PPARg in macrophages exacerbates the development of acid derivatives as well as synthetic ligands from the thiazolidi- atherosclerosis (10, 11), colitis (12), and obesity-induced insulin

*Department of Developmental and Regenerative Biology, Mount Sinai School of (10POST4160140), and A.C. is funded by a fellowship from the National Institutes Medicine, New York, NY 10029; †Immunology Institute, Mount Sinai School of of Health, National Heart, Lung, and Blood Institute 5F30HL099028-02. Medicine, New York, NY 10029; ‡Department of Pathology and Immunology, Wash- x The datasets presented in this article have been submitted to the National Center for ington University, St. Louis, MO 63110; Department of Oncological Sciences, { Biotechnology Information/Gene Expression Omnibus (http://www.ncbi.nlm.nih. Mount Sinai School of Medicine, New York, NY 10029; Institute for Vascular gov/geo/) under accession numbers GSE15907 and GSE32034. Medicine, Friedrich Schiller University of Jena, Jena University Hospital, 07743 Jena, Germany; ‖Albert Einstein College of Medicine, Bronx, NY 10461; Address correspondence and reprint requests to Dr. Emmanuel L. Gautier and and #Department of Molecular Cell Biology, Free University Medical Center, 1007 Dr. Gwendalyn J. Randolph, Department of Pathology and Immunology, Washington Amsterdam, The Netherlands University, 660 South Euclid Avenue, Campus Box 8118, St. Louis, MO 63110. E-mail addresses: [email protected] (E.L.G.) and [email protected]. 1Current address: Integrated Department of Immunology, National Jewish Health, edu (G.J.R.) University of Colorado, Denver, CO. The online version of this article contains supplemental material. Received for publication February 9, 2012. Accepted for publication July 4, 2012. Abbreviations used in this article: DC, dendritic cell; 15d-PGJ , 15-deoxy-d-12,14-PG This work was supported by National Institutes of Health Grants AI061741 and 2 J2; FABP4, fatty acid binding protein 4; PAP, pulmonary alveolar proteinosis; PPAR, AI049653 and American Heart Association Established Investigator Award peroxisome proliferator-activated receptor. 0740052 (to G.J.R.), National Institutes of Health Grant HL086899 (to M.M.), Deut- sche Forschungsgemeinschaft Project Grant SP71314-1 (to R.S.), and Deutsche Ó Forschungsgemeinschaft Project Grants Ha 1083/16-1 and Ha 1083/15-1 (to A.J.H.). Copyright 2012 by The American Association of Immunologists, Inc. 0022-1767/12/$16.00 E.L.G. is supported by a fellowship from the American Heart Association www.jimmunol.org/cgi/doi/10.4049/jimmunol.1200495 The Journal of Immunology 2615 resistance (13). On the basis of these studies, a model emerges subsets were CD11c+MHC II+ cells that differentially expressed CD4 + + 2 2 2 + wherein macrophages are universally central targets of PPARg (CD11b CD4 CD8 ) or CD8 (CD11b CD4 CD8 ) (21). RNA was pre- modulation. However, it is not known whether all monocyte/ pared from sorted populations from C57BL/6J mice after sorting directly into TRIzol reagent, amplified, and hybridized on the Affymetrix Mouse macrophage populations express PPARg or rely on its activation Gene 1.0 ST. For data analysis using ImmGen datasets, raw data for all to maintain homeostasis or to carry out their functions in different populations were normalized using the robust multiarray averaging algo- organs during inflammation. Ultimately, the design and develop- rithm. Extensive quality control documents are available on the Immgen ment of therapeutic strategies based on the use of PPARg agonists Web site. All datasets have been deposited at the National Center for Biotechnology Information/Gene Expression Omnibus under accession to combat inflammatory diseases would benefit from the identifi- number GSE15907 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc= cation of the specific macrophage populations potentially respon- GSE15907). Microarrays on blood monocytes treated with a PPARg ag- sive to these agonists. onist were performed as previously described (15) using Affymetrix GeneChip In this context, we decided to profile the expression of PPARg 430 2.0 arrays. Corresponding datasets have been deposited at National in a range of macrophage populations extracted from different Center for Biotechnology Information/Gene Expression Omnibus under accession number GSE32034 (http://www.ncbi.nlm.nih.gov/geo/query/acc. organs, delineate its preferential site of expression, and examine cgi?acc=GSE32034). the impact of its deficiency during the steady state and after in- flammatory challenge in relevant tissues. We show in vivo that Blood and tissue sample preparation for flow cytometry PPARg is induced in monocytes recruited to sites of inflammation Mouse blood was collected by nonterminal submandibular or terminal as they differentiate into macrophages, and its function is required cardiac puncture, and RBCs were lysed in hypotonic buffer (PharmLyse; to fully turn off inflammatory cell recruitment during resolution. BD Biosciences). Total leukocytes were quantitated by fresh blood dilution

In resting tissue macrophages, PPARg expression was found to be in Turk’s solution (Ricca Chemical). Lungs were harvested, minced, in- Downloaded from cubated in HBSS containing 3% FBS and collagenase D for 1 h, passed restricted to specific populations, which are lung and splenic red through an 18-gauge needle to obtain homogeneous cell suspensions, and pulp macrophages. In the lung but not the spleen, deficiency of filtered using a 100-mm cell strainer. Bronchoalveolar lavage was obtained PPARg in macrophages was associated with low-level spontane- by flushing the airways four times with HBSS. Spleens were minced, ous inflammation in the steady state and profound alterations placed into the cup portion of a cell strainer, and then gently mashed and pushed through the cell strainer. RBCs were then lysed in hypotonic buffer. in macrophage gene expression. Challenge with Streptococcus Peritoneal exudates were collected using cold HBSS. Cell suspensions pneumoniae revealed that deletion of PPARg in lung macrophages were then stained with appropriate Abs for 30 min on ice, and data were http://www.jimmunol.org/ impaired host defense, delaying bacterial clearance and thereby acquired on a BD FACSCanto II Flow Cytometer (BD Biosciences) and accelerating infection-induced mortality. Overall, these findings analyzed with FlowJo software (Tree Star). uncovered a key role of macrophage PPARg in supporting reso- Fluorescent conjugates of anti-mouse CD115 (AFS98), F4/80 (BM8), CD45 (30-F11), CD11c (N418), IA-IE (M5/114.15.2), CD4 (GK1.5), CD8 lution of inflammation while pointing specifically to the lung as (53-6.7), CD45.2 (104), and CD45.1 (A20) were purchased from eBio- a central organ where the function of PPARg goes beyond an anti- science. Anti-mouse Gr-1 (Ly-6C/G and RB6-8C5) and CD36 (HM36) were inflammatory role and extends critically into maintenance of host purchased from BioLegend. Anti-mouse F4/80 (CI:A3-1) was purchased defense. from Serotec. Anti-mouse CD36 (CRF D-2712), Ly6G (1A8), and siglec F (E50-2440) were purchased from BD Biosciences. Anti-mouse fatty acid binding protein 4 (FABP4) (BAF1443) was from R&D Systems. Materials and Methods by guest on September 29, 2021 Animals and treatments Immunoblot analysis LysM-cre mice (C57BL/6J) and PPARg floxed mice (C57BL/6J) were FACS sorted cells were homogenized in lysis buffer containing protease obtained from The Jackson Laboratory and crossed in house to generate inhibitors. Protein extracts were run on Criterion gels (Bio-Rad) and blotted mice with PPARg deficiency in myeloid cells (hereafter named LysM- onto nitrocellulose membranes. After blocking, immunoblots were incu- Cre 3 PPARgflox/flox). LysM-cre 3 Rosa26-stopfloxEGFP reporter mice bated with primary Abs against PPARg and b-actin (Cell signaling). Blots were bred in-house. Csf2rb2/2Csf2rb22/2 and C57BL/6J control mice were then incubated with fluorescent secondary Abs and proteins were were obtained from The Jackson Laboratory. For acute inflammation and detected using the fluorescence-based Odyssey Infrared Imaging System resolution experiments, peritonitis was induced by i.p. injection of 1 ml (LI-COR Biosciences). sterile thioglycollate (3% w/v; Sigma-Aldrich). Induction of inflammation in the spleen was achieved by i.v. LPS injection (Escherichia coli 026:B6; Macrophage transfer 20 mg/mouse). For infection experiments, mice were inoculated intrana- Peritoneal macrophages were retrieved by lavage from CD45.2 Lys-Cre 3 6 5 sally with 2 3 10 or 5 3 10 CFU Streptococcus pneumoniae serotype 3 PPARgflox/flox and wild-type controls 5 d after thioglycollate instillation. (ATCC number 6303; American Type Culture Collection), and survival Then, 5 3 106 macrophages were injected into the peritoneum of naive was assessed every other day over a period of 12 d. Mice were housed in CD45.1 wild-type mice, and the number of recruited CD45.1+ neutrophils a specific pathogen-free environment and used in accordance with proto- was assessed 24 h later. cols approved by the Institutional Animal Care and Utilization Committee at Mount Sinai School of Medicine. Monocyte labeling in vivo Microarray analysis Ly-6Clo monocytes were labeled in vivo by i.v. injection of 1 mm Fluo- + resbrite green fluorescent (YG) plain microspheres (Polysciences) diluted Monocytes were identified as CD115 low side-scatter cells and sorted into 1:4 in sterile PBS (22, 23). Ly-6Chi monocytes were labeled with beads two subsets based on Ly6-C expression as described previously (14, 15). using the same protocol, except that beads were administered 3 d after i.v. All other microarrays on mononuclear phagocytes were carried out as part injection of clodronate-loaded liposomes (250 ml/mouse) (22). Labeling of the Immunological Genome Project (http://www.immgen.org) (16). The efficiency was verified by flow cytometry 1 and/or 2 d after labeling by isolation procedures and corresponding flow plots for all cells can be found analysis of blood collected i.v. through the submandibular vein. Clodronate on the ImmGen Web site. Steady-state macrophages from the peritoneum + hi 2 was a gift from Roche and was incorporated into liposomes as described were sorted into two populations (17), including CD115 F4/80 MHC II previously (24). Ly6-C2B2202 and CD115+ F4/80loMHC II+Ly6-C2B2202 populations; + int 2 2 inflamed peritoneal macrophages were CD115 F4/80 Ly6-C B220 , Analysis of gene expression by quantitative real-time PCR whereas neutrophils were sorted as Ly6-G+Ly6-CintCD1152B2202 cells. In the lung, macrophages were sorted as CD11c+MHC IIloSiglecF+ RNA samples were prepared using TRIzol reagent (Invitrogen) from CD11b2 cells (18), and lung dendritic cells (DCs) as CD11c+MHC II+ thioglycollate-elicited macrophages isolated from mice at sacrifice. Each cells that were either CD11b+ (CD11b+ DCs) or CD103+ (CD103+ DCs) RNA preparation was hybridized with oligo dT (Invitrogen) and reverse (18). Brain microglia were sorted as CD45loCD11b+F4/80+ cells (19). Gut transcribed using Superscript III reverse transcriptase (Invitrogen). Quan- macrophages were CD45+CD11cloMHC II+CD1032CD11b+ cells (20). In titative real-time PCR was performed using a LightCycler PCR System the spleen, red pulp macrophages were F4/80hiMHCint cells, and DC (Roche) as described previously (25). Expression data were analyzed by 2616 PPARg CONTROLS SPECIFIC MACROPHAGE POPULATIONS crossing points calculated from the LightCycler data analysis software and Ly6-Clo monocytes increased CD36 expression in response to corrected for PCR efficiencies of both the target and the reference gene. pioglitazone in a PPARg-dependent manner (Fig. 1E). FABP4 was Analysis of bacterial burden differentially expressed among lung macrophages, raising the possibility of heterogeneity in this population, and its expression Bacterial burden was quantified by plating 10 ml of lung homogenates was completely dependent on PPARg, whether at baseline or after serially diluted in trypticase soy broth (BD) on blood agar plates (trypticase soy broth plus 1.875% agar plus 5% sheep blood). After incubating plates at pioglitazone treatment. By contrast, basal FABP4 was not de- 37˚C for 18–24 h, colonies were counted. pendent on PPARg in spleen macrophages, although it was re- sponsive to induction by pioglitazone in a PPARg-dependent Statistical analysis manner (Fig. 1E). Overall, these data point to a great diversity in Data are expressed as mean 6 SEM. Statistical differences were assessed PPARg expression among resting differentiated macrophages, using a two-tailed t test or ANOVA (with Tukey’s posttest analysis) with indicating that PPARg upregulation is not necessarily an inevita- GraphPad Prism software. A p value ,0.05 was considered statistically significant. ble consequence of macrophage development (27) and revealing that the expression of putative PPARg target genes are regulated somewhat differently in different tissue macrophage populations. Results Differential expression of PPARg and regulation of canonical Acquisition of PPARg expression by Ly-6Chi monocyte-derived PPARg target genes among different tissue macrophage inflammatory macrophages is necessary for full resolution of populations acute inflammation

To better understand the role of PPARg in mononuclear phago- PPARg activity has been associated with anti-inflammatory re- Downloaded from cytes, we first assessed PPARg mRNA expression in blood sponses. In the inflammatory milieu of the thioglycollate-treated monocytes, resident macrophages from different tissues, including peritoneum, elicited macrophages from the peritoneal cavity ex- the lung, splenic red pulp, brain (microglia), gut, and peritoneum, pressed 3-fold higher PPARg mRNA than blood Ly-6Chi mono- as well as in inflammatory peritoneal macrophages. For mono- cytes (Fig. 2A) from which they derive (14, 28). PPARg was cytes, we independently assessed the two major circulating subsets functional in these cells because PPARg activation using a syn-

that in mice differentially express Ly6-C and which have coun- thetic ligand increased cell surface expression of the PPARg-in- http://www.jimmunol.org/ terparts in other species, including humans (14, 26). We compared ducible protein CD36 (data not shown), and PPARg was these populations to spleen and lung conventional DC subsets as efficiently deleted in these cells in LysM-Cre 3 PPARgflox/flox well as neutrophils. The populations were sorted (see http://www. mice (Fig. 2B). In wild-type mice, leukocytes accumulate for immgen.org for detailed sorting strategies) and further analyzed several days after thioglycollate injection, with a marked resolu- by gene array. PPARg mRNA was differentially expressed over tion phase between days 5 and 8 when inflammatory macrophage several orders of magnitude in different mononuclear phagocytes numbers decline to baseline levels (29). To examine whether (Fig. 1A). Macrophages from the steady-state peritoneum, brain, PPARg deficiency in Ly-6Chi monocyte-derived inflammatory and gut expressed only low levels of PPARg, equivalent to the peritoneal macrophages would alter the initiation and/or the res- signal intensity in Ly-6Chi blood monocytes and neutrophils. By olution of thioglycollate-induced inflammation, we used LysM- by guest on September 29, 2021 contrast, high levels of PPARg mRNA were observed in Ly-6Clo Cre 3 PPARgflox/flox mice that in this study lack PPARg expres- monocytes, splenic red pulp macrophages, and pulmonary mac- sion specifically in macrophages, because neutrophils do not rophages (Fig. 1A). Consistent with this, treatment of wild-type express PPARg. First, using LysM-Cre 3 Rosa26-stopfloxEGFP mice with the PPARg agonist rosiglitazone induced further ex- reporter mice to identify cells with use of the LysM promoter pression of the PPARg-inducible CD36 protein at the cell surface using GFP expression, we confirmed that .90% of inflammatory of Ly-6Clo but not Ly-6Chi monocytes in wild-type animals, macrophages in the inflamed peritoneum would be targeted in suggesting that only the Ly-6Clo but not Ly6-Chi monocytes were LysM-Cre 3 PPARgflox/flox mice in addition to macrophages in responsive to PPARg activation (Fig. 1B). Indeed, PPARg acti- resting peritoneum and neutrophils (data not shown). In the steady vation profoundly impacted the transcriptome of Ly-6Clo mono- state, the total numbers of the two peritoneal resident macro- cytes (602 genes downregulated and 1222 genes upregulated, phage populations (17) (CD115+F480hiMHC-II2 or CD115+ 2-fold cutoff) (Fig. 1C, Supplemental Table I) and especially af- F480loMHC-II+) were unchanged in LysM-Cre 3 PPARgflox/flox fected gene signatures such as “DC maturation,” “p53 signaling,” mice as compared with controls, and the numbers of infiltrated and “NFATand immune response” (E.L. Gautier and G.J. Randolph, neutrophils and Ly-6Chi monocytes were similarly very low in the unpublished observations). By contrast, Ly-6Chi monocytes presence or absence of PPARg (data not shown). were largely unresponsive to the agonist (66 genes downregulated During the course of peritonitis, early accumulation of CD115hi and 77 genes upregulated) (Fig. 1C, Supplemental Table II), inflammatory macrophages (Fig. 2C) in the peritoneum was un- suggesting that the levels of PPARg in Ly-6Chi monocytes, and by altered by PPARg deficiency 1 d after instillation of thioglycollate extension in neutrophils, DCs, steady-state peritoneum, brain, and butwasslightlydecreasedafter5and8dinLysM-Cre3 gut macrophages, are too low to confer significant responsiveness PPARgflox/flox mice (Fig. 2D). However, we noted a 3-5-fold in- to PPARg ligands under homeostatic conditions. This was further crease in the number of infiltrated Ly-6Chi monocytes at both days confirmed as neutrophils, DCs, and peritoneal macrophages did 5 and 8 compared with control mice (Fig. 2C, 2E), whereas cir- not upregulate the expression of the two prototypic PPARg target culating monocyte subset numbers remained similar over time in genes CD36 and FABP4 following PPARg agonist treatment both LysM-Cre 3 PPARgflox/flox mice and controls (data not (pioglitazone), whereas other populations that express PPARg shown). Because Ly-6C is retained only transiently after monocyte upregulated CD36 and/or FAPB4 (Fig. 1D). Populations that recruitment into tissues (26, 30, 31), these data revealed that upregulated CD36 and FABP4 in response to PPARg agonists monocyte recruitment to the peritoneal cavity did not fully shut typically did so in a PPARg-dependent manner (Fig. 1E), but down in LysM-Cre 3 PPARgflox/flox mice. Furthermore, although diversity in expression of these canonical PPARg targets was early accumulation of neutrophils (6 and 24 h) was comparable substantial. Lung macrophages did not express surface levels of between LysM-Cre 3 PPARgflox/flox mice and control animals, CD36, even after PPARg agonist treatment (Fig. 1E), but blood peritoneal neutrophil numbers were likewise elevated 3- to 4-fold The Journal of Immunology 2617 Downloaded from http://www.jimmunol.org/ by guest on September 29, 2021

FIGURE 1. PPARg gene expression profiling and regulation of canonical PPARg target genes in mononuclear phagocytes. (A)PPARg mRNA expression was analyzed by gene array and depicted to show signal intensity in sorted myeloid cell populations. Data are derived from three separate analyses that are each derived from n = 5 mice. (B) Cell surface expression of CD36 analyzed by flow cytometry on monocyte subsets from mice fed a regular chow diet (2) or a diet supplemented with the PPARg agonist rosiglitazone (agonist) for a week (n = 5 mice/group). (C) The number of genes regulated in monocyte subsets following PPARg activation by rosiglitazone assessed through whole-genome array analysis. (D) Protein levels of CD36 and FABP4 in myeloid populations at the steady state and following PPARg agonist treatment (agonist, pioglitazone) were monitored by flow cytometry. (E) Expression of CD36 and FABP4 in myeloid populations of LysM-Cre 3 PPARgflox/flox mice (PPARgΔMac/PMN) and controls (CTRL) at the steady state and following PPARg agonist treatment (agonist, pioglitazone). Mean fluorescence intensity (MFI) is plotted (n = 3–4 mice/group). Mf, Macrophage. 2618 PPARg CONTROLS SPECIFIC MACROPHAGE POPULATIONS Downloaded from http://www.jimmunol.org/

FIGURE 2. PPARg expression in peritoneal inflammatory macrophages favors the resolution of acute inflammation. (A) Relative PPARg mRNA ex- pression in inflammatory macrophages from the peritoneum and their peripheral blood Ly-6Chi monocyte precursors. (B) Western blot analysis of PPARg protein in cell-sorted thioglycollate-elicited peritoneal macrophages. (C) FACS plot illustrating the gating strategy used for inflammatory peritoneal macrophages (Mf; CD115+ Gr-1/Ly-6C2), Ly-6Chi monocytes (CD115+Gr-1/Ly-6C+), and polymorphonuclear neutrophils (PMN; Gr-1/Ly-6G+CD115lo/2) in the peritoneal cavity 5 d after initiation of peritonitis. (D) Inflammatory peritoneal macrophage number in LysM-Cre 3 PPARgflox/flox mice (PPARgΔMac/PMN) and controls (CTRL) during the course of thioglycollate-induced peritonitis (n = 5–9 mice/group). (E) Ly-6Chi monocyte numbers in the peritoneal cavity at 5 and 8 d postinduction of peritonitis (n = 8–14/group). (F) Neutrophil counts in the peritoneum at 0.25, 1, 5, and 8 d after peritonitis flox/flox ΔMac/PMN induction (n = 4–12 mice/group). (G) Inflammatory peritoneal macrophages from LysM-Cre 3 PPARg mice (PPARg ) and controls (CTRL) by guest on September 29, 2021 (both CD45.2) were transferred into naive CD45.1 recipients, and recipient neutrophils recruitment was evaluated 24 h later (n = 6–8 mice/group). (H) Circulating Ly-6Chi monocytes were labeled i.v. with latex fluorescent beads 3 d after induction of inflammation, and the number of recruited bead-positive Ly-6Chi monocytes in the peritoneal cavity was assessed 48 h later in LysM-Cre 3 PPARgflox/flox mice (PPARgΔMac/PMN) and controls (CTRL) (n = 6–7 mice/group). (I) Quantification of mRNA expression by peritoneal inflammatory macrophages recovered 5 d after induction of inflammation assessed by quantitative real-time PCR for select genes (n = 5 mice/group).

in LysM-Cre 3 PPARgflox/flox mice during the usual resolution PPARg activation promotes macrophage-dependent cessation phase occurring between days 5 and 8 (Fig. 2F). Concomitantly, of neutrophil recruitment and favors resolution of acute blood neutrophil counts were elevated at these later time points in inflammation 3 flox/flox LysM-Cre PPARg mice compared with controls (data not Given the data above indicating that the cessation of leukocyte shown), marking systemic inflammation. Interestingly, the in- hi recruitment that characterizes resolution of inflammation is im- crease in peritoneal neutrophils and Ly-6C monocytes, as well as paired in LysM-Cre 3 PPARgflox/flox mice, we sought to determine the decrease in inflammatory macrophages, were still evident at whether treatment with PPARg agonists would conversely favor day 14 postthioglycollate treatment, the latest time point examined the shutdown of leukocyte recruitment in wild-type animals. In- 3 6 (data not shown). Transfer of 5 10 thioglycollate-elicited deed, PPARg agonist treatment reduced neutrophil counts in the macrophages, retrieved from donors during the early resolution peritoneum following thioglycollate administration at each time period at day 5, to the peritoneum of resting mice led to recruit- point studied, especially in the later phases of inflammation (Fig. ment of neutrophils (Fig. 2G) and monocytes (Fig. 2H), and these 3A). This effect required PPARg expression in macrophages be- numbers were doubled when transferred macrophages lacked cause treatment with the PPARg agonist failed to reduce neutro- PPARg.PPARg-deficient thioglycollate-elicited macrophages, phil counts in the cavity of LysM-Cre 3 PPARgflox/flox mice (Fig. retrieved at day 5, had increased mRNA expression of Il1b, Il6, 3B). These data support the concept that PPARg activation sup- and Ccr2 and decreased levels of Cd36, Cd51, and Tgfb1 com- presses the recruitment of leukocytes in later phases of tissue in- pared with controls (Fig. 2I). Collectively, these data show that jury in a macrophage PPARg-dependent manner, promoting PPARg deficiency in myeloid cells has little impact on the early resolution of inflammation. phases of an inflammatory response. However, macrophage PPARg expression in thioglycollate-elicited inflammatory macrophages is PPARg deletion in macrophages leads to low-grade necessary to bring about resolution. Indeed, its deficiency leads to constitutive inflammation in the lung but not in the spleen a state of chronic low-grade inflammation, at least in part because Considering our findings that PPARg expression in inflammatory macrophages retain a more proinflammatory phenotype. macrophages as well as its activation by pharmacological agonists The Journal of Immunology 2619

were similar in LysM-Cre 3 PPARgflox/flox mice and controls (data not shown), but red pulp macrophages (F4/80hi CD11blo) were approximately one-third less numerous in LysM-Cre 3 PPARgflox/flox spleens (Fig. 4A), possibly arguing for a role of PPARg in the maintenance of this population. There were no signs of inflammation in the resting spleen of LysM-Cre 3 PPARgflox/flox mice because splenic Ly-6Chi monocyte and neutrophil numbers were comparable to controls (Fig. 4B). Consistent with peritoneal inflammation, macrophage PPARg deficiency did not have an FIGURE 3. PPARg activation favors the resolution of acute inflamma- impact on the induction of inflammation in the spleen at an early tion. (A) Neutrophil counts in the peritoneum at 1, 5, and 8 d after peri- 2 time point after i.v. administration of LPS (day 1; Fig. 4C), whereas tonitis induction in wild-type mice fed a regular diet ( ) or a diet hi containing the PPARg agonist pioglitazone (agonist) (n = 8–10 mice/ it led to increased neutrophils and Ly-6C monocytes recruitment group). (B) Peritoneal neutrophil counts 5 d after peritonitis induction in to the spleen at a later time point (day 5; Fig. 4D), again arguing for LysM-Cre 3 PPARgflox/flox mice (PPARgΔMac/PMN) fed a regular diet (2) a key role of PPARg in resolution of inflammation. or a diet containing the PPARg agonist pioglitazone (agonist) (n = 4–5 When we examined the lung, we observed that PPARg deletion mice/group). in macrophages led to a low-grade inflammatory response without supplying an overt exogenous stimulus. Indeed, we observed in- creased leukocyte infiltration with elevated numbers of neutrophils favors resolution of acute inflammation, we wondered whether (Fig. 4E) and CD4+ and CD8+ T lymphocytes (Fig. 4F), whereas Downloaded from deletion of PPARg in resting macrophage populations that nor- macrophage numbers were comparable to controls (Fig. 4E). mally express high levels of PPARg (lung and splenic red pulp Overall, whereas PPARg is expressed by both splenic red pulp macrophages) would promote inflammation. LysM-Cre 3 Rosa26- and pulmonary macrophages, its deficiency only obviously had an stopfloxEGFP reporter mice confirmed that resident lung and impact on lung tissue homeostasis in the steady state, arguing for splenic red pulp macrophages would be targeted in LysM-Cre 3 an interaction between tissue environment and the outcome of flox/flox PPARg mice (data not shown). Total splenocyte numbers altered macrophage PPARg signaling. http://www.jimmunol.org/ by guest on September 29, 2021

FIGURE 4. Impact of PPARg deletion in splenic red pulp and lung macrophage. (A) Red pulp macrophage percentages and counts in the spleen of LysM- Cre 3 PPARgflox/flox mice (PPARgΔMac/PMN) and controls (CTRL) in the steady state (n = 4 mice/group). (B) Neutrophil and Ly-6Chi monocyte counts in the spleen of LysM-Cre 3 PPARgflox/flox mice (PPARgΔMac/PMN) and controls (CTRL) in the steady state (n = 4 mice/group). (C) Neutrophil and Ly-6Chi monocyte counts in the spleen of LysM-Cre 3 PPARgflox/flox mice (PPARgΔMac/PMN) and controls (CTRL) 24 h after LPS was injected i.v. (n = 3 mice/ group). (D) FACS plot illustrating the gating strategy used for Ly-6Chi monocytes (CD115hiGr-1/Ly-6C+) and neutrophils (Gr-1/Ly-6G+CD115lo), and neutrophil and Ly-6Chi monocyte counts in the spleen of LysM-Cre 3 PPARgflox/flox mice (PPARgΔMac/PMN) and controls (CTRL) 5 d after i.v. admin- istration of LPS (n = 3 mice/group). (E) FACS plot illustrating the gating strategy used for lung macrophages (CD11c+Siglec-F+) and neutrophils (CD11b+ Ly-6G+) and respective cell counts in the lung of LysM-Cre 3 PPARgflox/flox mice (PPARgΔMac/PMN) and controls (CTRL) in the steady state (n = 6–8 mice/ group). (F) CD4+ and CD8+ T lymphocyte counts in the lung of LysM-Cre 3 PPARgflox/flox mice (PPARgΔMac/PMN) and controls (CTRL) in the steady state (n = 6–8 mice/group). 2620 PPARg CONTROLS SPECIFIC MACROPHAGE POPULATIONS

Altered gene expression and lipid homeostasis in lung profile was mirrored by decreased expression of genes involved macrophages deficient in PPARg in the cholesterol biosynthetic pathway (Hmgcs1, Srebf2, Hmgcr, The low-grade inflammation observed only in the lung but not in Fdft1, Dhcr24, Sqle, and Idi1) and in the uptake of extracellular the spleen suggested that the impact of PPARg might be envi- cholesterol (Ldlr) (Fig. 5B). Because the vast majority of these ronment dependent. The alveolar space is permanently filled with genes are not known to be under the direct control of PPARg, a surfactant made of lipids (90%) and proteins (10%) (32), and we these data suggest that many of the genes regulated in this study noted increased cellular lipid content in lung macrophages lacking are regulated indirectly. Because we observed an increase in + 3 PPARg, as indicated by increased sterol staining using Bodipy FL the percentage of MHC-II lung macrophages in LysM-Cre flox/flox (Fig. 5A), in line with previous work reporting the development PPARg mice (Fig. 5C), we sought to determine whether this of pulmonary alveolar proteinosis in these mice (33, 34). Then, was correlated with an increased expression of genes associated to better understand the role of PPARg in lung macrophages, with macrophage activation. We found increased mRNA levels of microarray analysis was performed on sorted lung macrophages genes encoding costimulatory molecules (Cd86, H2-DMb2, H2- from LysM-Cre 3 PPARgflox/flox mice and controls. This whole- Ab1, and H2-Aa), members of the IFN regulatory factor family of genome array analysis uncovered 721 genes that were downreg- transcription factors (Irf3, Irf5, and Irf8), innate immune receptors ulated, and 2088 genes whose expression was increased in lung (Tlr7, Tlr8, and Trem2), and the proinflammatory mediator Mif macrophages lacking PPARg, highlighting a profound alteration (Fig. 5D). Moreover, mRNA expression levels of members of the of their transcriptome (Supplemental Tables III, IV). In line with S100 protein family (S100a13, S100a4, and S100a6), known to their increased intracellular sterol content, we found that PPARg- mediate inflammatory signals, were upregulated in lung macro- flox/flox Downloaded from deficient lung macrophages induced a number of mRNA tran- phages from LysM-Cre 3 PPARg mice (Fig. 5D). However, scripts associated with cellular lipid metabolism and in particular other genes involved in inflammation such as transcription factors those associated with an increase in activity of the LXR tran- (Fos, Nr4a1, Jun, Jund, and Junb), the TLR Tlr2, the scavenger scription factor. Expression levels of Nr1h2 (also known as receptor Marco, and the surfactant opsonin Sftpc were downreg- LXRb), a sensor of intracellular sterol levels, and its partner Rxra ulated (Fig. 5D). Consistent with the increased intracellular lipid were increased in lung macrophages obtained from LysM-Cre 3 content observed in lung macrophages from LysM-Cre 3 PPARgflox/flox mice as compared with controls (Fig. 5B). Conse- PPARgflox/flox mice, we noted that the mRNA expression of sev- http://www.jimmunol.org/ quently, the expression levels of several target genes of the LXR/ eral phospholipases (Pla2g6, Plcb1, Pnpla6, Pld3, and Pld4) was RXR heterodimer (Abca1, Srebf1, Apoe, Mylip, Abcg1, Scd2, and increased in these cells as well as the expression of genes involved Scd1) were equally increased (Fig. 5B). Finally, the mRNA level in PG and thromboxane synthesis (Pgs1, Ptgr2, Ptgs1,and of the scavenger receptor Msr1 and of the triacylglycerol synthesis Tbxas1) (Fig. 5E). We also noted that numerous genes regulated enzyme Dgat1 were also enhanced (Fig. 5B). This expression by the transcription factor Nrf2, a master regulator of the anti- by guest on September 29, 2021

FIGURE 5. PPARg is critical to preserve lung macrophage cellular homeostasis. (A) Cellular lipid levels were assessed in resting lung macrophages from LysM-Cre 3 PPARgflox/flox mice (PPARgΔMac/PMN) and controls (CTRL) using Bodipy-FL staining (n = 3 mice/group). (B) mRNA expression of genes modulated by intracellular lipid levels was determined by microarray. (C) Flow cytometry plot and quantification of cell surface MHC-II protein levels in lung macrophages from LysM-Cre 3 PPARgflox/flox mice (PPARgΔMac/PMN) and controls (CTRL) (n = 3–4 mice/group). Heat maps representing mRNA levels of genes involved in macrophage activation (D), lipid signaling (E), oxidative stress signaling (F), and cell death/autophagy (G). The Journal of Immunology 2621 oxidant response, were upregulated in PPARg-deficient pulmo- of the bacteria into the bloodstream (data not shown) as well as ac- nary macrophages compared with controls, indicating increased celerated death in these mice (Fig. 6C). LysM-Cre 3 PPARgflox/flox oxidative stress in LysM-Cre 3 PPARgflox/flox mice (Fig. 5F). mice challenged with a lower dose of the pathogen similarly suc- Finally, mRNA levels of mediators of autophagy (Atg5, Dram1, cumbed faster than controls. Indeed, whereas 100% of control Becn1, and Atg7) and apoptosis (Casp2, Casp9, Bax,andAifm2) mice were still alive 6 d postinfection, only 40% of LysM-Cre 3 wereincreasedinlungmacrophageslackingPPARg compared with PPARgflox/flox mice survived to this time point (Fig. 6D). Sur- controls (Fig. 5G). Taken together, these findings reveal that PPARg- prisingly, we observed similar neutrophil and Ly-6Chi monocyte deficient pulmonary macrophages present a markedly altered tran- recruitment to the bronchoalveolar space and the lung 24 h scriptome, most likely secondary to the lipid loading, affecting postinfection in LysM-Cre 3 PPARgflox/flox mice and controls several key pathways related to classical macrophage functions. (Fig. 6E). Increased bacterial burden in LysM-Cre 3 PPARgflox/flox mice was not due to impaired phagocytosis because labeled Impaired bacterial clearance in the lungs and accelerated S. pneumoniae were taken up by PPARg-deficient alveolar mac- mortality in mice lacking PPARg in macrophages following rophages as efficiently as controls in vivo (Fig. 6F). However, S. pneumoniae infection resident alveolar and interstitial pulmonary macrophage counts Given that the gene expression profile of lung macrophages defi- were significantly decreased by ∼50 and 35%, respectively, 24 h cient in PPARg is profoundly altered, we next investigated after instillation of S. pneumoniae (Fig. 6G). Finally, the disease whether infectious challenge of LysM-Cre 3 PPARgflox/flox mice pulmonary alveolar proteinosis (PAP) is due to alterations in GM- would lead to a perturbed innate immune response to pathogens. CSF signaling, and it was recently shown that PPARg expression

In this study, we found that LysM-Cre 3 PPARgflox/flox mice were in GM-CSF–deficient lung macrophages was low (35). Further- Downloaded from more susceptible to infection with S. pneumoniae. Weight loss more, viral vectors to restore PPARg in GM-CSF knockout mice associated with infection was more pronounced in LysM-Cre 3 led to reduced lipid accumulation and increased cholesterol efflux PPARgflox/flox compared with controls over a period of 4 d before in lung macrophages (36). Because PAP is associated with increased death occurred (Fig. 6A). This increased susceptibility to S. susceptibility to infection, we sought to determine whether PPARg pneumoniae infection was due to impaired bacterial clearance activation could improve bacterial clearance in Csf2rb2/2Csf2rb22/2 2/2 2/2 because bacterial burden was increased by ∼1 log in the lung of mice (37). Indeed, Csf2rb Csf2rb2 mice, which also display http://www.jimmunol.org/ LysM-Cre 3 PPARgflox/flox mice compared with controls 48 h alveolar proteinosis, have significantly higher bacterial burden postinfection (Fig. 6B). This correlated with faster dissemination (∼2 logs) than wild-type control mice and PPARg activation by by guest on September 29, 2021

FIGURE 6. PPARg expression in lung macrophage is necessary to combat infection. (A) Body weight loss was determined following infection in LysM- Cre 3 PPARgflox/flox mice (PPARgΔMac/PMN) and controls (CTRL) (n = 9 mice/group). (B) Lung bacterial load was measured 48 h postinfection in LysM- Cre 3 PPARgflox/flox mice (PPARgΔMac/PMN) and controls (CTRL) (n = 9 mice/group). Survival from infection was assessed over a period of 12 d following high-dose (2 3 106 CFU) (C) and low-dose (5 3 105 CFU) (D) S. pneumoniae inoculation in the lung of LysM-Cre 3 PPARgflox/flox mice (PPARgΔMac/PMN) and controls (CTRL) (n = 5–8 mice/group). (E) Neutrophil and Ly-6Chi monocyte counts in the bronchoalveolar lavage (BAL) and the lung of LysM-Cre 3 PPARgflox/flox mice (PPARgΔMac/PMN) and controls (CTRL) were determined 24 h postinfection (n = 7–8 mice/group). (F) PKH26-labeled S. pneumoniae phagocytosis by resident alveolar macrophages was assessed by flow cytometry 30 min after inoculation (n = 6 mice/group). (G) Alveolar and pulmonary- resident macrophages counts in LysM-Cre 3 PPARgflox/flox mice (PPARgΔMac/PMN) and controls (CTRL) 24 h postinfection (n = 7–8 mice/group). (H) Lung bacterial burden was determined 48 h after S. pneumoniae inoculation in the lungs of wild-type mice, Csf2rb2/2Csf2rb22/2 mice, and Csf2rb2/2Csf2rb22/2 mice with prior treatment with the PPARg agonist pioglitazone for 2 wk (n = 3–4 mice/group). 2622 PPARg CONTROLS SPECIFIC MACROPHAGE POPULATIONS pioglitazone partially decreased this enhanced burden (Fig. 6H). At present, resolvins are known not to serve as PPARg ligands Therefore, these data now connect PPARg to host defense and (42), but an intersection between PPARg and the pathways that control of bacterial burden in the lung through maintenance of regulate such proresolution mediators may exist. Ligands for local macrophage functions. PPARg during resolution may be limiting, because we observed that provision of synthetic ligands to mice hastened the shutdown Discussion of neutrophil recruitment in a macrophage PPARg-dependent The anti-inflammatory role of PPARg in macrophages is well manner during the terminal phases of thioglycollate-induced in- established. However, little is known regarding its impact on flammation. This finding is in line with recent published data in specific resting macrophage populations as well as on the dynamic a model of granulomatous disease (43) and supports the logic of of inflammation in vivo. It was recently recognized that estab- therapeutically enhancing PPARg activity to promote resolution of lishing the expression profile of PPARg in tissue macrophages ongoing inflammation. in vivo would be helpful in clarifying its role in the regulation Highest expression of PPARg mRNA among macrophages in of inflammatory processes (38). In this study, we unexpectedly the mouse, resting or inflamed, was observed in the lung. Analysis revealed that many resident macrophages do not express sub- of FABP4 expression in lung macrophages suggests that there may stantial levels of PPARg, including those in the brain, peritoneum, be heterogeneity among lung macrophages with regard to ex- and gut. The level of PPARg in these cells was as low as in Ly- pression or activity of PPARg. We show that the absence of 6Chi monocytes, which show no PPARg activity after synthetic PPARg in LysM-Cre 3 PPARgflox/flox mice induced mild lung PPARg agonist administration in vivo. By contrast to these tissues inflammation in the absence of experimental challenge. This un- and cells, Ly-6Clo blood monocytes and resting red pulp splenic derlying inflammation may stem from a key role for PPARg ex- Downloaded from and pulmonary macrophages expressed high levels of mRNA for pression by macrophages to maintain cellular as well as tissue lipid PPARg. In addition, PPARg was induced in inflammatory mac- homeostasis in the presence of pulmonary surfactant lipids. Indeed, rophages differentiating from circulating Ly-6Chi monocytes en- previous work indicates that lipid surfactant accumulates in the tering an inflammatory site, albeit to a lower level than observed alveoli of LysM-Cre 3 PPARgflox/flox mice (33, 34). Consistent in the resting macrophages that were positive. In different tissues, with this observation, we found that expressions of genes that

the expression of canonical PPARg target genes such as CD36 and regulate intracellular lipid homeostasis are markedly altered in http://www.jimmunol.org/ FABP4 was distinct even among those macrophages that were pulmonary macrophages lacking PPARg. Genes involved in sterol PPARg+, highlighting the importance of context in regulation of uptake and synthesis were downregulated, whereas genes linked to PPARg-related pathways and underscoring the diversity observed cholesterol sensing and efflux were upregulated, and in particular, among macrophages from different organs. mRNA transcripts controlled by LXR were induced. Likely, the Because the ability of PPARg to transrepress inflammatory genes enhanced sterol loading drives induction of the LXR pathway as has been thoroughly documented (1), we expected that macrophage a mechanism to deal with the high lipid loading. In addition, we loss of PPARg during thioglycollate-mediated peritonitis would found that numerous pathways associated with a range of macro- lead to a more proinflammatory phenotype. However, the absence phage functions were altered in the absence of PPARg in lung of PPARg in LysM-Cre 3 PPARgflox/flox mice did not impact the macrophages, and genes associated with cell death were upregu- by guest on September 29, 2021 accumulation of leukocytes during the initial phase of the inflam- lated, leading to the conclusion that disruption of PPARg signaling matory response. This could be explained by the fact that immature profoundly altered their transcriptome. However, the changes in and differentiating Ly-6Chi monocytes, which express negligible or gene expression are complex and most likely do not reflect changes low levels of PPARg, were dominant at this time point. By contrast, associated only with direct PPARg targets. Indirect changes likely persistent neutrophil and Ly-6Chi monocyte influx occurs in LysM- reflect a sequence of events that occur in response to the loss of Cre 3 PPARgflox/flox mice during the later period when more dif- PPARg in macrophages, which usually express PPARg in the lung. ferentiated inflammatory macrophages, which now express PPARg, With the expectation that the absence of PPARg in lung mac- begin to dominate and when resolution is observed in control rophages would exacerbate inflammation in the context of infec- mice. These data suggest, therefore, that PPARg plays especially tion and subsequently favor bacterial clearance, we infected important roles in the late stages and resolution of inflammation. control and LysM-Cre 3 PPARgflox/flox mice with S. pneumoniae. These roles very likely include repression of proinflammatory Bolstering our expectations that the inflammatory infiltrate may be genes, and indeed, we observed that proinflammatory genes were increased in response to this infection were data in the literature elevated in PPARg-deficient thioglycollate-elicited macrophages indicating that mice lacking the cholesterol efflux gene Abcg1, and but may also include impaired induction of genes associated with thus a gene expected to intersect functionally with PPARg, man- repair and healing. Previous studies have linked PPARg with the ifest enhanced inflammation and increased bacterial clearance in development of alternatively activated macrophages (39) and with response to infection in the lung (44). Following infection, weight tissue repair in injured muscle (30), and IL-4 is known to promote loss and mortality were surprisingly accelerated in LysM-Cre 3 the production of PPARg ligands (40). An elegant in-depth study PPARgflox/flox mice. As in the acute model of sterile inflammation recently revealed that although PPARg is not required for de- induced by thioglycollate, the number of infiltrating neutrophils velopment of alternatively activated macrophages in C57BL/6J and monocytes was not changed in the first days following in- mice, there is synergy with IL-4 such that the transcription fac- fection. Further similar to the thioglycollate model, but far more tor Stat6 that is critical for IL-4 signaling binds to the enhancer pronounced, the number of mature macrophages was significantly elements in PPARg target genes and markedly augments the reduced in LysM-Cre 3 PPARgflox/flox mice following infection PPARg response (41). Our findings that PPARg appears to play with S. pneumoniae, although macrophage counts were similar a bigger role in determining the rate/magnitude of contraction of to control mice in the steady state. These reduced macrophage the inflammatory response rather than the magnitude of earlier numbers may account for the associated observation that clearance phases fits well with concepts of PPARg playing a key role in of S. pneumoniae was impaired under these conditions. Although tissue repair, healing, and overall resolution. we were unable to find more nonviable macrophages (using Future studies on the possible interface between PPARg and annexin V as a readout), the upregulation of cell death genes even lipids previously associated with resolution (42) seem in order. in the steady state is consistent with this idea, and other explana- The Journal of Immunology 2623 tions such as impaired phagocytosis of bacteria were eliminated. ABCA1 pathway in macrophages is involved in cholesterol efflux and athero- genesis. Mol. Cell 7: 161–171. Although future work will be required to be sure that macrophage 12. Shah, Y. M., K. Morimura, and F. J. Gonzalez. 2007. Expression of peroxisome flox/flox death accounts for why LysM-Cre 3 PPARg mice succumb proliferator-activated receptor-g in macrophage suppresses experimentally in- to S. pneumoniae infection more than control mice, we believe that duced colitis. Am. J. Physiol. Gastrointest. Liver Physiol. 292: G657–G666. 13. Hevener, A. L., J. M. Olefsky, D. Reichart, M. T. Nguyen, G. Bandyopadyhay, the observation that macrophage PPARg deficiency impacts the H. Y. Leung, M. J. Watt, C. Benner, M. A. Febbraio, A. K. Nguyen, et al. 2007. outcome of infection is quite significant on its own. Patients with Macrophage PPARg is required for normal skeletal muscle and hepatic insulin PAP, a disease linked to impaired GM-CSF signaling, have an sensitivity and full antidiabetic effects of thiazolidinediones. J. Clin. Invest. 117: 1658–1669. increased risk of superinfection (32), and it is known that sup- 14. Geissmann, F., S. Jung, and D. R. Littman. 2003. Blood monocytes consist of pressed GM-CSF signaling leads to lower PPARg levels in the two principal subsets with distinct migratory properties. Immunity 19: 71–82. lung (35). Moreover, Csf2rb2/2Csf2rb22/2 mice, a mouse model 15. Ingersoll, M. A., R. Spanbroek, C. Lottaz, E. L. Gautier, M. Frankenberger, R. Hoffmann, R. Lang, M. Haniffa, M. Collin, F. Tacke, et al. 2010. Comparison of PAP, are more susceptible to S. pneumoniae infection (37). of gene expression profiles between human and mouse monocyte subsets. Blood Although it was already recognized that increasing PPARg in 115: e10–e19. 16. Heng, T. S., and M. W. Painter. 2008. The Immunological Genome Project: models of PAP might reverse aspects of the disease such as lipid networks of gene expression in immune cells. Nat. Immunol. 9: 1091–1094. accumulation in macrophages, our data substantiate a link between 17. Ghosn, E. E., A. A. Cassado, G. R. Govoni, T. Fukuhara, Y. Yang, the loss of PPARg per se and increased susceptibility to infection D. M. Monack, K. R. Bortoluci, S. R. Almeida, L. A. Herzenberg, and L. A. Herzenberg. 2010. Two physically, functionally, and developmentally in PAP. Importantly, downregulation of PPARg and/or impairment distinct peritoneal macrophage subsets. Proc. Natl. Acad. Sci. USA 107: 2568– in PPARg signaling is also observed in cystic fibrosis (45–47), and 2573. PPARg agonist treatment has been recently shown to ameliorate 18. Sung, S. S., S. M. Fu, C. E. Rose, Jr., F. Gaskin, S. T. Ju, and S. R. Beaty. 2006. A major lung CD103 (aE)-b7 integrin-positive epithelial dendritic cell population the severity of the cystic fibrosis phenotype in mice (47). Because expressing Langerin and tight junction proteins. J. Immunol. 176: 2161–2172. Downloaded from cystic fibrosis is also tightly associated with an increased sus- 19. Ginhoux, F., M. Greter, M. Leboeuf, S. Nandi, P. See, S. Gokhan, M. F. Mehler, ceptibility to lung infection (48), PPARg may participate centrally S. J. Conway, L. G. Ng, E. R. Stanley, et al. 2010. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 330: 841–845. in impacting susceptibility to infection there as well. Future studies 20. Bogunovic, M., F. Ginhoux, J. Helft, L. Shang, D. Hashimoto, M. Greter, K. Liu, to investigate this possibility will be very important. C. Jakubzick, M. A. Ingersoll, M. Leboeuf, et al. 2009. Origin of the lamina propria dendritic cell network. Immunity 31: 513–525. In summary, through taking the approach that started with 21. Waskow, C., K. Liu, G. Darrasse-Je`ze, P. Guermonprez, F. Ginhoux, M. Merad, characterization of the diversity of macrophages with respect to T. Shengelia, K. Yao, and M. Nussenzweig. 2008. The receptor tyrosine kinase http://www.jimmunol.org/ expression of PPARg, the present work illustrates that PPARg acts Flt3 is required for dendritic cell development in peripheral lymphoid tissues. Nat. Immunol. 9: 676–683. at the cellular level to favor contraction of inflammation and in the 22. Tacke, F., F. Ginhoux, C. Jakubzick, N. van Rooijen, M. Merad, and steady state is expressed in specific macrophage populations, es- G. J. Randolph. 2006. Immature monocytes acquire antigens from other cells in pecially in lung macrophages where it is critically involved in the the bone marrow and present them to T cells after maturing in the periphery. J. Exp. Med. 203: 583–597. maintenance of host defense. 23. Potteaux, S., E. L. Gautier, S. B. Hutchison, N. van Rooijen, D. J. Rader, M. J. Thomas, M. G. Sorci-Thomas, and G. J. Randolph. 2011. Suppressed Acknowledgments monocyte recruitment drives macrophage removal from atherosclerotic plaques ‑/‑ We thank Christophe Benoist, Jeffrey Ericson, and Scott Davies for tech- of Apoe mice during disease regression. J. Clin. Invest. 121: 2025–2036. 24. Van Rooijen, N., and A. Sanders. 1994. Liposome mediated depletion of mac- nical assistance with microarray analysis through the Immunological Ge- rophages: mechanism of action, preparation of liposomes and applications. J. by guest on September 29, 2021 nome Project (R24 AI072073). We also thank the Flow Cytometry Core Immunol. Methods 174: 83–93. at the Mount Sinai School of Medicine for assistance in use of the facility 25. Gautier, E. L., T. Huby, B. Ouzilleau, C. Doucet, F. Saint-Charles, G. Gremy, for flow cytometric cell sorting. We thank Andy Platt and Julie Helft for M. J. Chapman, and P. Lesnik. 2007. Enhanced immune system activation and arterial inflammation accelerates atherosclerosis in lupus-prone mice. Arte- helpful discussion and reading of the manuscript. rioscler. Thromb. Vasc. Biol. 27: 1625–1631. 26. Qu, C., E. W. Edwards, F. Tacke, V. Angeli, J. Llodra´, G. Sanchez-Schmitz, Disclosures A. Garin, N. S. Haque, W. Peters, N. van Rooijen, et al. 2004. Role of CCR8 and The authors have no financial conflicts of interest. other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes. J. Exp. Med. 200: 1231–1241. 27. Moore, K. J., E. D. Rosen, M. L. Fitzgerald, F. Randow, L. P. Andersson, References D. Altshuler, D. S. Milstone, R. M. Mortensen, B. M. Spiegelman, and 1. Glass, C. K., and S. Ogawa. 2006. Combinatorial roles of nuclear receptors in M. W. Freeman. 2001. The role of PPAR-g in macrophage differentiation and inflammation and immunity. Nat. Rev. Immunol. 6: 44–55. cholesterol uptake. Nat. Med. 7: 41–47. 2. Tontonoz, P., and B. M. Spiegelman. 2008. Fat and beyond: the diverse biology 28. Tacke, F., D. Alvarez, T. J. Kaplan, C. Jakubzick, R. Spanbroek, J. Llodra, of PPARg. Annu. Rev. Biochem. 77: 289–312. A. Garin, J. Liu, M. Mack, N. van Rooijen, et al. 2007. Monocyte subsets dif- 3. Yki-Ja¨rvinen, H. 2004. Thiazolidinediones. N. Engl. J. Med. 351: 1106–1118. ferentially employ CCR2, CCR5, and CX3CR1 to accumulate within athero- 4. Ricote, M., A. C. Li, T. M. Willson, C. J. Kelly, and C. K. Glass. 1998. The sclerotic plaques. J. Clin. Invest. 117: 185–194. peroxisome proliferator-activated receptor-g is a negative regulator of macro- 29. Bellingan, G. J., H. Caldwell, S. E. Howie, I. Dransfield, and C. Haslett. 1996. phage activation. Nature 391: 79–82. In vivo fate of the inflammatory macrophage during the resolution of inflam- 5. Jiang, C., A. T. Ting, and B. Seed. 1998. PPAR-g agonists inhibit production of mation: inflammatory macrophages do not die locally, but emigrate to the monocyte inflammatory cytokines. Nature 391: 82–86. draining lymph nodes. J. Immunol. 157: 2577–2585. 6. Daynes, R. A., and D. C. Jones. 2002. Emerging roles of PPARs in inflammation 30. Arnold, L., A. Henry, F. Poron, Y. Baba-Amer, N. van Rooijen, A. Plonquet, and immunity. Nat. Rev. Immunol. 2: 748–759. R. K. Gherardi, and B. Chazaud. 2007. Inflammatory monocytes recruited after 7. Su, C. G., X. Wen, S. T. Bailey, W. Jiang, S. M. Rangwala, S. A. Keilbaugh, skeletal muscle injury switch into antiinflammatory macrophages to support A. Flanigan, S. Murthy, M. A. Lazar, and G. D. Wu. 1999. A novel therapy for myogenesis. J. Exp. Med. 204: 1057–1069. colitis utilizing PPAR-g ligands to inhibit the epithelial inflammatory response. 31. Cheong, C., I. Matos, J. H. Choi, D. B. Dandamudi, E. Shrestha, M. P. Longhi, J. Clin. Invest. 104: 383–389. K. L. Jeffrey, R. M. Anthony, C. Kluger, G. Nchinda, et al. 2010. Microbial 8. Mukherjee, R., P. J. Davies, D. L. Crombie, E. D. Bischoff, R. M. Cesario, stimulation fully differentiates monocytes to DC-SIGN/CD209+ dendritic cells L. Jow, L. G. Hamann, M. F. Boehm, C. E. Mondon, A. M. Nadzan, et al. 1997. for immune T cell areas. Cell 143: 416–429. Sensitization of diabetic and obese mice to insulin by retinoid X receptor ago- 32. Trapnell, B. C., J. A. Whitsett, and K. Nakata. 2003. Pulmonary alveolar pro- nists. Nature 386: 407–410. teinosis. N. Engl. J. Med. 349: 2527–2539. 9. Li, A. C., K. K. Brown, M. J. Silvestre, T. M. Willson, W. Palinski, and 33. Bonfield, T. L., M. J. Thomassen, C. F. Farver, S. Abraham, M. T. Koloze, C. K. Glass. 2000. Peroxisome proliferator-activated receptor g ligands inhibit X. Zhang, D. M. Mosser, and D. A. Culver. 2008. Peroxisome proliferator- development of atherosclerosis in LDL receptor-deficient mice. J. Clin. Invest. activated receptor-gamma regulates the expression of alveolar macro- 106: 523–531. phage macrophage colony-stimulating factor. J. Immunol. 181: 235– 10. Babaev, V. R., P. G. Yancey, S. V. Ryzhov, V. Kon, M. D. Breyer, 242. M. A. Magnuson, S. Fazio, and M. F. Linton. 2005. Conditional knockout of 34. Baker, A. D., A. Malur, B. P. Barna, S. Ghosh, M. S. Kavuru, A. G. Malur, and macrophage PPARg increases atherosclerosis in C57BL/6 and low-density li- M. J. Thomassen. 2010. Targeted PPARg deficiency in alveolar macrophages poprotein receptor-deficient mice. Arterioscler. Thromb. Vasc. Biol. 25: 1647–1653. disrupts surfactant catabolism. J. Lipid Res. 51: 1325–1331. 11. Chawla, A., W. A. Boisvert, C. H. Lee, B. A. Laffitte, Y. Barak, S. B. Joseph, 35. Thomassen, M. J., B. P. Barna, A. G. Malur, T. L. Bonfield, C. F. Farver, D. Liao, L. Nagy, P. A. Edwards, L. K. Curtiss, et al. 2001. A PPARg-LXR- A. Malur, H. Dalrymple, M. S. Kavuru, and M. Febbraio. 2007. ABCG1 is 2624 PPARg CONTROLS SPECIFIC MACROPHAGE POPULATIONS

deficient in alveolar macrophages of GM-CSF knockout mice and patients with 42. Serhan, C. N. 2010. Novel lipid mediators and resolution mechanisms in acute pulmonary alveolar proteinosis. J. Lipid Res. 48: 2762–2768. inflammation: to resolve or not? Am. J. Pathol. 177: 1576–1591. 36. Malur, A., A. D. Baker, A. J. McCoy, G. Wells, B. P. Barna, M. S. Kavuru, 43. Fernandez-Boyanapalli, R., S. C. Frasch, D. W. Riches, R. W. Vandivier, A. G. Malur, and M. J. Thomassen. 2011. Restoration of PPARg reverses lipid P. M. Henson, and D. L. Bratton. 2010. PPARg activation normalizes resolution accumulation in alveolar macrophages of GM-CSF knockout mice. Am. J. of acute sterile inflammation in murine chronic granulomatous disease. Blood Physiol. Lung Cell. Mol. Physiol. 300: L73–L80. 116: 4512–4522. 37. LeVine, A. M., J. A. Reed, K. E. Kurak, E. Cianciolo, and J. A. Whitsett. 1999. 44. Draper, D. W., J. H. Madenspacher, D. Dixon, D. H. King, A. T. Remaley, and GM-CSF‑deficient mice are susceptible to pulmonary group B streptococcal M. B. Fessler. 2010. ATP-binding cassette transporter G1 deficiency dysregulates infection. J. Clin. Invest. 103: 563–569. host defense in the lung. Am. J. Respir. Crit. Care Med. 182: 404–412. 38. Szanto, A., and L. Nagy. 2008. The many faces of PPARg: anti-inflammatory by 45. Ollero, M., O. Junaidi, M. M. Zaman, I. Tzameli, A. A. Ferrando, C. Andersson, any means? Immunobiology 213: 789–803. P. G. Blanco, E. Bialecki, and S. D. Freedman. 2004. Decreased expression of 39. Odegaard, J. I., R. R. Ricardo-Gonzalez, M. H. Goforth, C. R. Morel, peroxisome proliferator activated receptor gamma in cftr‑/‑ mice. J. Cell. Physiol. V. Subramanian, L. Mukundan, A. Red Eagle, D. Vats, F. Brombacher, 200: 235–244. A. W. Ferrante, and A. Chawla. 2007. Macrophage-specific PPARg controls 46. Maiuri, L., A. Luciani, I. Giardino, V. Raia, V. R. Villella, M. D’Apolito, alternative activation and improves insulin resistance. Nature 447: 1116–1120. M. Pettoello-Mantovani, S. Guido, C. Ciacci, M. Cimmino, et al. 2008. Tissue 40. Huang, J. T., J. S. Welch, M. Ricote, C. J. Binder, T. M. Willson, C. Kelly, transglutaminase activation modulates inflammation in cystic fibrosis via PPARg J. L. Witztum, C. D. Funk, D. Conrad, and C. K. Glass. 1999. Interleukin- down-regulation. J. Immunol. 180: 7697–7705. 4‑dependent production of PPAR-g ligands in macrophages by 12/15-lip- 47. Harmon, G. S., D. S. Dumlao, D. T. Ng, K. E. Barrett, E. A. Dennis, H. Dong, oxygenase. Nature 400: 378–382. and C. K. Glass. 2010. Pharmacological correction of a defect in PPAR-g sig- 41. Szanto, A., B. L. Balint, Z. S. Nagy, E. Barta, B. Dezso, A. Pap, L. Szeles, naling ameliorates disease severity in Cftr-deficient mice. Nat. Med. 16: 313–318. S. Poliska, M. Oros, R. M. Evans, et al. 2010. STAT6 transcription factor is 48. Grassme´, H., K. A. Becker, Y. Zhang, and E. Gulbins. 2010. CFTR-dependent a facilitator of the nuclear receptor PPARg-regulated gene expression in mac- susceptibility of the cystic fibrosis-host to Pseudomonas aeruginosa. Int. J. Med. rophages and dendritic cells. Immunity 33: 699–712. Microbiol. 300: 578–583. Downloaded from http://www.jimmunol.org/ by guest on September 29, 2021 Supplemental Table 1. Gene expression changes induced in Ly-6Clo monocytes by a PPARgamma agonist

Regulation P value Fold change Probe Set ID Gene Title Gene Symbol [rosi] vs [rosi] vs [rosi] vs [chow] [chow] [chow] 1452388_at heat shock protein 1A Hspa1a 139.65762 up 0.006465 1418649_at EGL nine homolog 3 (C. elegans) Egln3 108.01015 up 0.000000 1424382_at reticulocalbin 3, EF-hand calcium binding domain Rcn3 62.98254 up 0.000004 1417601_at regulator of G-protein signaling 1 Rgs1 58.510284 up 0.000523 1447806_s_at serine/arginine-rich protein specific kinase 3 Srpk3 55.15433 up 0.000001 1416271_at PERP, TP53 apoptosis effector Perp 47.23692 up 0.000001 1458701_at preimplantation protein 4 Prei4 45.49524 up 0.000000 1425809_at fatty acid binding protein 4, adipocyte Fabp4 40.35327 up 0.000126 1455966_s_at nudix (nucleoside diphosphate linked moiety X)-type motif 21 Nudt21 35.983814 up 0.000000 1427126_at heat shock protein 1B Hspa1b 35.82423 up 0.006103 1417946_at abhydrolase domain containing 3 Abhd3 35.549038 up 0.000000 1453840_at poly A binding protein, cytoplasmic 1 Pabpc1 33.94053 up 0.000019 1450734_at SEC16 homolog B (S. cerevisiae) Sec16b 29.074423 up 0.000000 1451675_a_at aminolevulinic acid synthase 2, erythroid Alas2 28.803509 down 0.000884 1418750_at plexin B3 Plxnb3 28.378847 up 0.000000 1427127_x_at heat shock protein 1B Hspa1b 27.75678 up 0.007185 1418189_s_at Metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA) Malat1 23.256142 down 0.000051 1440285_at protein phosphatase 1, regulatory (inhibitor) subunit 9A Ppp1r9a 23.17093 up 0.000065 1418188_a_at Metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA) Malat1 22.364264 down 0.000021 1422028_a_at E26 avian leukemia oncogene 1, 5' domain Ets1 20.210562 up 0.000034 1455978_a_at matrilin 2 Matn2 18.65704 up 0.000018 1424923_at serine (or cysteine) peptidase inhibitor, clade A, member 3G Serpina3g 18.459673 up 0.000666 1452318_a_at heat shock protein 1B Hspa1b 17.549349 up 0.004131 1431182_at heat shock protein 8 /// similar to heat shock protein 8 /// similar to heat shock protein 70 cognate Hspa8 /// LOC624853 17.417913 up 0.006739 1430997_at CD47 antigen (Rh-related antigen, integrin-associated signal transducer) Cd47 16.52157 up 0.000101 1435971_at regulating synaptic membrane exocytosis 3 Rims3 14.51709 up 0.000067 1434112_at latrophilin 2 /// similar to calcium-independent alpha-latrotoxin receptor homolog 2 LOC100048050 /// Lp 14.283992 up 0.000002 1456072_at protein phosphatase 1, regulatory (inhibitor) subunit 9A Ppp1r9a 13.875331 up 0.001543 1446614_at Diacylglycerol kinase zeta Dgkz 13.382049 up 0.000129 1418648_at EGL nine homolog 3 (C. elegans) Egln3 13.2887535 up 0.000004 1456003_a_at solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 Slc1a4 12.914285 down 0.000110 1427005_at polo-like kinase 2 (Drosophila) Plk2 12.9102 up 0.000002 1459908_at CD47 antigen (Rh-related antigen, integrin-associated signal transducer) Cd47 12.855997 up 0.000004 1440165_at Protein tyrosine phosphatase, receptor type, C Ptprc 12.816424 down 0.007575 1426112_a_at CD72 antigen Cd72 11.988435 up 0.000165 1448239_at heme oxygenase (decycling) 1 Hmox1 11.885434 up 0.011260 1438216_at ras responsive element binding protein 1 Rreb1 11.823531 up 0.000018 1459601_at SNF1-like kinase Snf1lk 11.703029 up 0.000745 1448390_a_at dehydrogenase/reductase (SDR family) member 3 Dhrs3 11.544733 up 0.000011 1448752_at carbonic anhydrase 2 Car2 11.393896 down 0.026579 1442643_at jumonji domain containing 3 Jmjd3 11.361434 up 0.000003 1423100_at FBJ osteosarcoma oncogene Fos 11.098112 up 0.001681 1421792_s_at triggering receptor expressed on myeloid cells 2 Trem2 10.978734 down 0.000018 1417381_at complement component 1, q subcomponent, alpha polypeptide C1qa 10.898928 down 0.032205 1417130_s_at angiopoietin-like 4 Angptl4 10.810896 up 0.000030 1448119_at 2,3-bisphosphoglycerate mutase Bpgm 10.788716 down 0.002679 1458354_x_at keratin 28 Krt28 10.754558 down 0.000251 1417714_x_at hemoglobin alpha, adult chain 1 /// hemoglobin alpha, adult chain 2 Hba-a1 /// Hba-a2 10.662892 down 0.000402 1447900_x_at ectonucleoside triphosphate diphosphohydrolase 4 /// similar to ectonucleoside triphosphate diphosphohEntpd4 /// LOC10004 10.37136 up 0.000135 1435554_at transmembrane and coiled coil domains 3 Tmcc3 10.037975 up 0.003146 1442083_at arginine/serine-rich coiled-coil 2 Rsrc2 9.9761715 up 0.000001 1435394_s_at ras homolog gene family, member C Rhoc 9.832328 up 0.000396 1434111_at latrophilin 2 /// similar to calcium-independent alpha-latrotoxin receptor homolog 2 LOC100048050 /// Lp 9.815081 up 0.000103 1429005_at malignant fibrous histiocytoma amplified sequence 1 Mfhas1 9.7641945 up 0.000004 1453321_at fibronectin type III domain containing 1 Fndc1 9.530104 up 0.000010 1437213_at nudix (nucleoside diphosphate linked moiety X)-type motif 21 Nudt21 9.359667 up 0.000188 1455221_at ATP-binding cassette, sub-family G (WHITE), member 1 Abcg1 9.35443 up 0.000190 1425434_a_at macrophage scavenger receptor 1 Msr1 9.145338 down 0.000205 1433741_at CD38 antigen Cd38 9.14471 up 0.001962 1431355_s_at transient receptor potential cation channel, subfamily M, member 7 Trpm7 9.060304 up 0.000003 1450955_s_at sortilin 1 Sort1 9.007896 up 0.000024 1433792_at nuclear receptor interacting protein 2 Nrip2 8.815211 up 0.012335 1419079_at sodium channel, nonvoltage-gated 1 gamma Scnn1g 8.470512 up 0.000011 1450783_at interferon-induced protein with tetratricopeptide repeats 1 Ifit1 8.393661 up 0.007271 1418043_at ATP-binding cassette, sub-family C (CFTR/MRP), member 5 Abcc5 8.274761 up 0.001381 1455886_at Casitas B-lineage lymphoma /// similar to Casitas B-lineage lymphoma Cbl /// LOC10004801 8.26739 down 0.018029 1444400_at retinoblastoma 1 Rb1 8.243177 up 0.006650 1423363_at sortilin 1 Sort1 8.241957 up 0.000297 1438495_at topoisomerase (DNA) I Top1 8.175612 up 0.003923 1417297_at inositol 1,4,5-triphosphate receptor 3 Itpr3 8.149012 up 0.000047 1448374_at mediator of RNA polymerase II transcription, subunit 28 homolog (yeast) Med28 8.127429 up 0.000000 1440813_s_at plexin B3 Plxnb3 8.056708 up 0.000044 1418493_a_at synuclein, alpha Snca 7.937796 down 0.016990 1415964_at stearoyl-Coenzyme A desaturase 1 Scd1 7.9134135 up 0.000142 1417150_at solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Slc6a4 7.905047 up 0.000927 1446228_at endoplasmic reticulum metallopeptidase 1 Ermp1 7.8794036 up 0.000099 1420704_at colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) /// similar to granulocy Csf2ra /// LOC100045 7.834162 up 0.000467 1437356_at Epstein-Barr virus induced gene 2 Ebi2 7.7717967 down 0.000392 1452771_s_at acyl-CoA synthetase long-chain family member 3 Acsl3 7.756343 up 0.000372 1415864_at 2,3-bisphosphoglycerate mutase Bpgm 7.6609883 down 0.003611 1438415_s_at Yip1 domain family, member 2 Yipf2 7.633133 up 0.000014 1420874_at twinfilin, actin-binding protein, homolog 1 (Drosophila) Twf1 7.5992403 up 0.000020 1443559_at Arginine/serine-rich coiled-coil 2 Rsrc2 7.595524 up 0.001091 1436686_at zinc finger protein 706 /// similar to zinc finger protein 706 LOC100042741 /// LO 7.5408416 up 0.002192 1439964_at transmembrane protein 170 Tmem170 7.5224543 up 0.000015 1426296_at RAD52 homolog (S. cerevisiae) Rad52 7.5153985 up 0.000175 1418920_at claudin 15 Cldn15 7.4160295 up 0.000211 1418949_at growth differentiation factor 15 Gdf15 7.3560658 up 0.009357 1460241_a_at ST3 beta-galactoside alpha-2,3-sialyltransferase 5 St3gal5 7.2726283 down 0.000003 1421187_at chemokine (C-C motif) receptor 2 Ccr2 7.1938047 down 0.000861 1436917_s_at G-protein signalling modulator 1 (AGS3-like, C. elegans) Gpsm1 7.1610227 up 0.000322 1441707_at Proteasome (prosome, macropain) subunit, alpha type 3 Psma3 7.1586866 up 0.000001 1443340_at calcium binding atopy-related autoantigen 1 Cbara1 7.098399 up 0.002206 1437100_x_at proviral integration site 3 Pim3 7.054456 up 0.000374 1440764_at v-raf murine sarcoma 3611 viral oncogene homolog Araf 7.0463977 up 0.000921 1433104_at pseudouridine synthase 3 Pus3 7.029007 up 0.000058 1437270_a_at cardiotrophin-like cytokine factor 1 Clcf1 7.028051 up 0.000084 1448261_at cadherin 1 Cdh1 7.007903 up 0.001093 1416601_a_at regulator of calcineurin 1 Rcan1 7.0047097 down 0.000003 1437633_at ankyrin repeat domain 11 Ankrd11 6.9502816 down 0.002096 1426208_x_at pleiomorphic adenoma gene-like 1 Plagl1 6.8744464 down 0.001086 1443793_x_at integrator complex subunit 1 Ints1 6.862221 up 0.000018 1415865_s_at 2,3-bisphosphoglycerate mutase Bpgm 6.6993203 down 0.007407 1420872_at guanylate cyclase 1, soluble, beta 3 Gucy1b3 6.6086407 up 0.016385 1424304_at two pore segment channel 2 Tpcn2 6.531948 up 0.001565 1416501_at 3-phosphoinositide dependent protein kinase-1 Pdpk1 6.5295672 up 0.000152 1451716_at v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) Mafb 6.5252695 down 0.000420 1445727_at ubiquitin protein ligase E3A Ube3a 6.5167303 up 0.000482 1425553_s_at huntingtin interacting protein 1 related Hip1r 6.4357324 up 0.001083 1419315_at SLAM family member 9 Slamf9 6.4196224 down 0.000018 1451360_at ERGIC and golgi 2 Ergic2 6.4148097 up 0.000150 1438165_x_at vesicle amine transport protein 1 homolog (T californica) Vat1 6.374745 up 0.000907 1430043_at tetratricopeptide repeat domain 19 Ttc19 6.3666697 up 0.000326 1460415_a_at CD40 antigen Cd40 6.361102 down 0.000488 1460192_at oxysterol binding protein-like 1A Osbpl1a 6.321668 up 0.000180 1441370_at Transmembrane and coiled coil domains 1 Tmcc1 6.3143663 down 0.000369 1449084_s_at SH3 domain protein D19 Sh3d19 6.2837753 up 0.000016 1444599_at Hect domain and RLD 4 Herc4 6.2794642 up 0.000165 1416034_at CD24a antigen Cd24a 6.259441 down 0.006649 1436502_at mitochondrial tumor suppressor 1 Mtus1 6.2463193 down 0.003706 1438300_at CDKN2A interacting protein Cdkn2aip 6.245291 up 0.000023 1444031_at calcium/calmodulin-dependent protein kinase II, delta Camk2d 6.2310843 up 0.002324 1419769_at CD22 antigen Cd22 6.179469 up 0.008910 1456403_at phosphoprotein associated with glycosphingolipid microdomains 1 Pag1 6.1528974 up 0.003697 1434055_at UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 Galnt9 6.140677 down 0.000000 1423141_at lysosomal acid lipase A Lipa 6.134374 up 0.000005 1442251_at valosin containing protein (p97)/p47 complex interacting protein 1 Vcpip1 6.132347 up 0.000421 1459966_at Oxysterol binding protein-like 7 Osbpl7 6.124998 up 0.001979 1450808_at formyl peptide receptor 1 Fpr1 6.124194 up 0.000260 1416157_at vinculin Vcl 6.1076307 down 0.000000 1450061_at ectodermal-neural cortex 1 Enc1 6.040791 up 0.000273 1444934_at zinc finger protein (C2H2 type) 276 Zfp276 6.0372725 up 0.005807 1416630_at inhibitor of DNA binding 3 Id3 5.9960446 down 0.003519 1430177_at ubiquitin-conjugating enzyme E2B, RAD6 homology (S. cerevisiae) Ube2b 5.9186788 up 0.000004 1448452_at interferon regulatory factor 8 Irf8 5.871053 down 0.000032 1443909_at Cleavage stimulation factor, 3' pre-RNA, subunit 3 Cstf3 5.8674765 up 0.000043 1434502_x_at solute carrier family 4 (anion exchanger), member 1 Slc4a1 5.8614054 down 0.032372 1424769_s_at caldesmon 1 Cald1 5.857807 up 0.012783 1448681_at interleukin 15 receptor, alpha chain Il15ra 5.8540444 up 0.000369 1416796_at non-catalytic region of tyrosine kinase adaptor protein 2 /// similar to SH2/SH3 adaptor protein LOC100044475 /// Nc 5.8500795 up 0.000053 1423271_at gap junction membrane channel protein beta 2 Gjb2 5.8488016 up 0.000932 1440246_at longevity assurance homolog 6 (S. cerevisiae) Lass6 5.84478 up 0.002247 1418468_at annexin A11 /// similar to Annexin A11 Anxa11 /// LOC10003 5.8172164 up 0.000003 1419766_at SNF1-like kinase Snf1lk 5.8074937 up 0.000338 1447877_x_at DNA methyltransferase (cytosine-5) 1 Dnmt1 5.776863 up 0.008402 1441465_at CCR4-NOT transcription complex, subunit 3 Cnot3 5.7755938 up 0.001793 1456143_at protein kinase C binding protein 1 Prkcbp1 5.738871 up 0.000026 1437797_at ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 Atp2a2 5.728364 up 0.000747 1450019_at chemokine (C-X3-C) receptor 1 /// similar to chemokine receptor CX3CR1 Cx3cr1 /// LOC10004 5.726032 down 0.002830 1448005_at SAM and SH3 domain containing 1 Sash1 5.71645 up 0.000439 1421852_at potassium channel, subfamily K, member 5 Kcnk5 5.7063537 up 0.001046 1455137_at Rap guanine nucleotide exchange factor (GEF) 5 Rapgef5 5.703957 up 0.002546 1436915_x_at lysosomal-associated protein transmembrane 4B Laptm4b 5.6843944 up 0.001198 1452815_at purinergic receptor P2Y, G-protein coupled 10 P2ry10 5.6837254 up 0.002169 1446079_at zinc finger, matrin type 2 Zmat2 5.682561 up 0.000174 1423522_at nucleoplasmin 3 /// nucleoplasmin 3, pseudogene 1 /// similar to Nucleoplasmin-3 LOC639633 /// Npm3 5.6626663 down 0.001133 1447685_x_at E26 avian leukemia oncogene 2, 3' domain Ets2 5.5863676 up 0.000432 1447846_x_at leukocyte receptor cluster (LRC) member 4 Leng4 5.570057 up 0.000336 1423835_at zinc finger protein 503 Zfp503 5.555141 up 0.000127 1455936_a_at RNA binding protein gene with multiple splicing Rbpms 5.5474257 up 0.000018 1450760_a_at inhibitor of growth family, member 3 Ing3 5.4889984 up 0.000036 1452954_at ubiquitin-conjugating enzyme E2C Ube2c 5.486971 down 0.014277 1436605_at transketolase Tkt 5.4648476 up 0.000898 1426818_at arrestin domain containing 4 Arrdc4 5.3965054 up 0.000638 1433532_a_at myelin basic protein Mbp 5.373032 up 0.001985 1438307_at high mobility group box 2 Hmgb2 5.344877 up 0.000472 1459884_at cytochrome c oxidase, subunit VIIc /// similar to cytochrome c oxidase, subunit VIIc Cox7c /// LOC100041 5.3390145 up 0.002382 1421287_a_at platelet/endothelial cell adhesion molecule 1 Pecam1 5.3268914 up 0.003320 1423356_at synaptosomal-associated protein Snap29 5.30217 up 0.000016 1443907_at leucyl/cystinyl aminopeptidase Lnpep 5.2861204 up 0.001175 1444323_at cyclin D3 Ccnd3 5.282582 up 0.000333 1437908_a_at endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 Ergic1 5.2799077 up 0.000160 1425863_a_at protein tyrosine phosphatase, receptor type, O Ptpro 5.200749 down 0.000320 1460216_at acyl-Coenzyme A dehydrogenase, short chain Acads 5.166567 up 0.000001 1449661_at Suppressor of zeste 12 homolog (Drosophila) Suz12 5.150877 up 0.000496 1460330_at annexin A3 Anxa3 5.1424484 down 0.011647 1417813_at inhibitor of kappaB kinase epsilon Ikbke 5.1313696 up 0.000043 1438942_x_at transglutaminase 2, C polypeptide Tgm2 5.1215415 up 0.000322 1416001_a_at coactosin-like 1 (Dictyostelium) Cotl1 5.114456 down 0.000065 1420893_a_at transforming growth factor, beta receptor I Tgfbr1 5.1088996 down 0.023480 1427982_s_at synaptic nuclear envelope 2 Syne2 5.0884194 up 0.000085 1426164_a_at upstream transcription factor 1 Usf1 5.084931 up 0.010660 1447084_at nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 Nfatc1 5.0799894 up 0.019811 1452922_at protein phosphatase 1, regulatory subunit 3D Ppp1r3d 5.0736794 up 0.029127 1456429_at mucosa associated lymphoid tissue lymphoma translocation gene 1 Malt1 5.0542774 down 0.000062 1434873_a_at centaurin, beta 1 /// similar to Centaurin, beta 1 Centb1 /// LOC10004 5.0442357 up 0.003639 1437594_x_at phosphatidylinositol glycan anchor biosynthesis, class T /// similar to GPI transamidase component PIG LOC100046871 /// Pig 5.0305467 up 0.000766 1441477_at calumenin Calu 5.0269938 up 0.001554 1459766_x_at Splicing factor 1 Sf1 4.979938 down 0.000166 1436767_at LUC7-like 2 (S. cerevisiae) Luc7l2 4.968293 down 0.000511 1442959_at baculoviral IAP repeat-containing 6 Birc6 4.961201 up 0.000169 1455438_at peroxisomal membrane protein 4 Pxmp4 4.9423094 up 0.000190 1446807_at ubiquitin specific peptidase 8 Usp8 4.9421115 down 0.005834 1426639_a_at transcription factor 7-like 2, T-cell specific, HMG-box Tcf7l2 4.941591 up 0.000273 1452661_at transferrin receptor Tfrc 4.939396 up 0.000411 1422836_at muscleblind-like 3 (Drosophila) Mbnl3 4.9202294 up 0.003050 1450884_at CD36 antigen Cd36 4.8992295 up 0.000151 1434974_at pyruvate dehydrogenase kinase, isoenzyme 1 Pdk1 4.8933144 up 0.000951 1436853_a_at synuclein, alpha Snca 4.8743362 down 0.021125 1439296_at LIM domain only 6 Lmo6 4.864995 down 0.000091 1455257_at integrin beta 3 Itgb3 4.8584228 up 0.000697 1441238_at PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae) Pds5a 4.840847 down 0.002810 1439121_at histocompatibility 2, T region locus 22 H2-T22 4.818014 up 0.001043 1439406_x_at phenylalanine-tRNA synthetase 2 (mitochondrial) Fars2 4.751461 up 0.001514 1449041_a_at thyroid hormone receptor interactor 6 Trip6 4.7235107 up 0.000385 1448830_at dual specificity phosphatase 1 Dusp1 4.707498 up 0.003256 1421511_at integrin beta 3 Itgb3 4.704156 up 0.014551 1443002_at zinc finger RNA binding protein Zfr 4.697138 up 0.000320 1434252_at transmembrane and coiled coil domains 3 Tmcc3 4.6904383 up 0.009126 1427348_at zinc finger CCCH type containing 12A Zc3h12a 4.6815844 up 0.000081 1434357_a_at karyopherin (importin) beta 1 Kpnb1 4.667932 down 0.006210 1419967_at SEH1-like (S. cerevisiae Seh1l 4.6615863 up 0.000112 1435396_at syntaxin binding protein 6 (amisyn) Stxbp6 4.6605167 down 0.006786 1460069_at structural maintenance of chromosomes 6 Smc6 4.650824 down 0.000309 1435085_at cAMP responsive element binding protein-like 2 Crebl2 4.6382146 up 0.000088 1454042_a_at serine/arginine-rich protein specific kinase 1 Srpk1 4.6332917 up 0.000173 1427347_s_at tubulin, beta 2a Tubb2a 4.628417 up 0.000048 1445693_at v-raf murine sarcoma 3611 viral oncogene homolog Araf 4.6139894 up 0.007082 1426873_s_at junction plakoglobin Jup 4.6077137 up 0.000314 1450413_at platelet derived growth factor, B polypeptide Pdgfb 4.597974 down 0.000280 1448511_at protein tyrosine phosphatase, receptor type, C polypeptide-associated protein Ptprcap 4.594275 down 0.000842 1428447_at transmembrane protein 14A Tmem14a 4.5915666 up 0.008885 1436297_a_at glutamate receptor, ionotropic, N-methyl D-asparate-associated protein 1 (glutamate binding) Grina 4.5834475 up 0.000017 1443625_at N-acetyltransferase 11 Nat11 4.5771503 up 0.010192 1443822_s_at CDGSH iron sulfur domain 1 Cisd1 4.5760727 up 0.000068 1451886_at SPEG complex locus Speg 4.5611176 down 0.000163 1446550_at G1 to S phase transition 1 Gspt1 4.5587273 up 0.004314 1439487_at ligase IV, DNA, ATP-dependent Lig4 4.5536356 up 0.000183 1417513_at ecotropic viral integration site 5 Evi5 4.5450873 down 0.003792 1416954_at solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10 Slc25a10 4.5275855 up 0.000025 1454037_a_at FMS-like tyrosine kinase 1 Flt1 4.519876 down 0.004198 1455324_at phosphatidylinositol-specific phospholipase C, X domain containing 2 Plcxd2 4.5142465 up 0.000208 1442864_at estrogen related receptor, alpha Esrra 4.4974074 up 0.000160 1449952_s_at transmembrane protease, serine 8 (intestinal) Tmprss8 4.497204 up 0.009756 1456625_at aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Aasdhppt 4.496355 up 0.001284 1418204_s_at allograft inflammatory factor 1 Aif1 4.493549 down 0.001732 1449078_at ST3 beta-galactoside alpha-2,3-sialyltransferase 6 St3gal6 4.4902787 down 0.000785 1421928_at Eph receptor A4 Epha4 4.4900527 up 0.004734 1449129_a_at Kv channel interacting protein 3, calsenilin Kcnip3 4.4820304 up 0.009339 1451832_at chemokine-like factor Cklf 4.4730554 up 0.012965 1440770_at B-cell leukemia/lymphoma 2 Bcl2 4.4676237 up 0.012211 1426169_a_at linker for activation of T cells family, member 2 Lat2 4.4668207 down 0.000015 1439548_at RAP2B, member of RAS oncogene family Rap2b 4.465495 up 0.003624 1419381_at telomeric repeat binding factor 2, interacting protein Terf2ip 4.4652886 up 0.000374 1437358_at WD repeat and FYVE domain containing 1 Wdfy1 4.451731 up 0.000832 1416239_at argininosuccinate synthetase 1 Ass1 4.450563 down 0.028198 1441962_at arachidonate 5-lipoxygenase Alox5 4.450357 down 0.000005 1452487_x_at paired-Ig-like receptor A2 Pira2 4.4382105 down 0.000070 1454944_at hypermethylated in cancer 2 Hic2 4.42426 up 0.000005 1442167_at cytoplasmic FMR1 interacting protein 2 Cyfip2 4.3912964 up 0.000195 1450350_a_at Jun dimerization protein 2 Jundm2 4.3837194 up 0.001068 1420965_a_at ectodermal-neural cortex 1 Enc1 4.3817143 up 0.000636 1449732_at zinc finger and SCAN domain containing 21 Zscan21 4.375271 up 0.005495 1459857_at ubiquitin specific peptidase 32 Usp32 4.372613 up 0.003377 1446847_at coiled-coil domain containing 88C Ccdc88c 4.3684154 up 0.000162 1437500_at Nucleolar complex associated 3 homolog (S. cerevisiae) Noc3l 4.3639245 up 0.000013 1418926_at zinc finger E-box binding homeobox 1 Zeb1 4.3307714 up 0.000508 1459728_at ISY1 splicing factor homolog (S. cerevisiae) Isy1 4.31734 up 0.000577 1449390_at G patch domain containing 4 Gpatch4 4.301029 down 0.000292 1437159_at Galactosidase, beta 1 Glb1 4.295585 up 0.000197 1435043_at phospholipase C, beta 1 Plcb1 4.283881 up 0.001937 1451775_s_at interleukin 13 receptor, alpha 1 Il13ra1 4.2832594 down 0.000019 1428878_a_at phosphatidylinositol transfer protein, cytoplasmic 1 Pitpnc1 4.2761917 down 0.002442 1427866_x_at Beta globin 4.27331 down 0.002359 1427165_at interleukin 13 receptor, alpha 1 Il13ra1 4.2699614 down 0.000005 1426541_a_at endonuclease domain containing 1 Endod1 4.2671847 down 0.000845 1449353_at zinc finger matrin type 3 Zmat3 4.2662134 up 0.000013 1445705_x_at dipeptidylpeptidase 8 Dpp8 4.2657156 down 0.000459 1448883_at legumain Lgmn 4.240651 down 0.000044 1438527_at ribosomal protein L3 /// similar to Ribosomal protein L3 /// predicted gene, EG545864 /// similar to 60S r EG545864 /// LOC100 4.238105 up 0.013059 1441536_at 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 Hmgcs1 4.215987 up 0.001535 1416002_x_at coactosin-like 1 (Dictyostelium) Cotl1 4.2114053 down 0.000005 1424354_at transmembrane protein 140 Tmem140 4.203516 up 0.001280 1434339_at formin binding protein 1-like Fnbp1l 4.1937065 up 0.003995 1455191_x_at Phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha Pip5k1a 4.1758833 up 0.000054 1416021_a_at fatty acid binding protein 5, epidermal /// similar to Fatty acid-binding protein, epidermal (E-FABP) (Psor Fabp5 /// LOC547041 4.1671667 up 0.000018 1433768_at palladin, cytoskeletal associated protein Palld 4.1637435 up 0.000444 1438766_at proline-rich nuclear receptor coactivator 2 Pnrc2 4.162601 up 0.000062 1448713_at signal transducer and activator of transcription 4 Stat4 4.1480737 down 0.010606 1456844_at calcium/calmodulin-dependent protein kinase II, delta Camk2d 4.137692 up 0.000037 1425686_at CASP8 and FADD-like apoptosis regulator Cflar 4.13513 down 0.006035 1438816_at AT hook containing transcription factor 1 Ahctf1 4.133203 up 0.000071 1435685_x_at ATP-binding cassette, sub-family C (CFTR/MRP), member 5 Abcc5 4.129631 up 0.000017 1425426_a_at myocyte enhancer factor 2A /// similar to Myocyte enhancer factor 2A LOC100047837 /// Me 4.126797 down 0.001155 1445340_at pam, highwire, rpm 1 Phr1 4.1220245 down 0.001189 1429477_at non-SMC condensin II complex, subunit H2 Ncaph2 4.099068 up 0.000011 1426458_at sarcolemma associated protein Slmap 4.0825915 down 0.001511 1430399_at protection of telomeres 1B Pot1b 4.074226 down 0.003781 1458142_at zinc finger, DHHC domain containing 9 Zdhhc9 4.069829 up 0.000294 1419477_at C-type lectin domain family 2, member d Clec2d 4.066161 up 0.000005 1457198_at neuropilin 1 Nrp1 4.0625644 down 0.003682 1440384_at transmembrane and coiled coil domains 1 Tmcc1 4.059958 up 0.002651 1429021_at Eph receptor A4 Epha4 4.0467634 up 0.001329 1441650_at Rho GTPase activating protein 15 Arhgap15 4.03449 down 0.008000 1419768_at CD22 antigen Cd22 4.030073 up 0.000688 1435684_at ATP-binding cassette, sub-family C (CFTR/MRP), member 5 Abcc5 4.0235333 up 0.000047 1442368_at potassium channel tetramerisation domain containing 12b Kctd12b 4.019766 up 0.030053 1434743_x_at RUN and SH3 domain containing 1 Rusc1 4.019066 up 0.000054 1417184_s_at hemoglobin, beta adult major chain /// hemoglobin, beta adult minor chain Hbb-b1 /// Hbb-b2 3.9953198 down 0.000168 1457434_s_at protein tyrosine phosphatase-like (proline instead of catalytic arginine), member a Ptpla 3.988595 up 0.000928 1424899_at nicotinamide nucleotide adenylyltransferase 3 Nmnat3 3.987972 up 0.000192 1438365_x_at lysosomal-associated protein transmembrane 4B Laptm4b 3.9798892 up 0.000625 1438183_x_at sorbitol dehydrogenase Sord 3.9739819 up 0.002670 1456632_at B-cell CLL/lymphoma 11A (zinc finger protein) Bcl11a 3.9646134 up 0.010184 1425063_at Fc receptor-like 1 Fcrl1 3.947623 up 0.002199 1418835_at pleckstrin homology-like domain, family A, member 1 Phlda1 3.9450796 up 0.001483 1453977_at exocyst complex component 4 Exoc4 3.942386 up 0.000412 1419734_at actin, beta, cytoplasmic Actb 3.9318447 down 0.003851 1449702_at zinc finger, AN1-type domain 2A Zfand2a 3.9308002 up 0.000089 1419245_at RAB14, member RAS oncogene family Rab14 3.9262114 up 0.009468 1421802_at eosinophil-associated, ribonuclease A family, member 1 Ear1 3.9057071 down 0.004437 1420710_at reticuloendotheliosis oncogene Rel 3.9049804 up 0.001568 1436911_at synovial sarcoma translocation gene on chromosome 18-like 1 Ss18l1 3.897024 up 0.000485 1437965_at HEAT repeat containing 1 Heatr1 3.8944705 up 0.000074 1422659_at calcium/calmodulin-dependent protein kinase II, delta Camk2d 3.8914328 up 0.000409 1440647_at signal-induced proliferation-associated 1 like 1 Sipa1l1 3.878785 up 0.014132 1453596_at inhibitor of DNA binding 2 Id2 3.865565 up 0.006617 1448405_a_at EP300 interacting inhibitor of differentiation 1 Eid1 3.8549573 up 0.002523 1455656_at B and T lymphocyte associated Btla 3.8489609 down 0.000018 1453237_at glutaminyl-tRNA synthetase Qars 3.8441792 up 0.015757 1439926_at HEG homolog 1 (zebrafish) Heg1 3.8311841 up 0.001962 1456288_at schlafen 5 Slfn5 3.8309145 up 0.017832 1459827_x_at Hermansky-Pudlak syndrome 1 homolog (human) Hps1 3.8225427 up 0.001370 1439631_at zinc finger, CCHC domain containing 11 Zcchc11 3.8215575 up 0.016126 1439863_at UDP-glucose ceramide glucosyltransferase Ugcg 3.8141193 up 0.000225 1441930_x_at Vesicle amine transport protein 1 homolog (T californica) Vat1 3.8098173 up 0.000011 1428361_x_at hemoglobin alpha, adult chain 1 /// hemoglobin alpha, adult chain 2 Hba-a1 /// Hba-a2 3.808387 down 0.000530 1442212_at carboxypeptidase D /// similar to carboxypeptidase D Cpd /// LOC10004678 3.805298 up 0.002445 1425537_at protein phosphatase 1A, magnesium dependent, alpha isoform Ppm1a 3.8034687 up 0.003925 1431749_a_at RAS guanyl releasing protein 1 Rasgrp1 3.7930477 down 0.012173 1449519_at growth arrest and DNA-damage-inducible 45 alpha Gadd45a 3.7903945 up 0.004831 1429562_at Sp110 nuclear body protein Sp110 3.7891746 up 0.001558 1425115_at retinoblastoma binding protein 6 Rbbp6 3.78494 up 0.016968 1433679_at far upstream element (FUSE) binding protein 3 Fubp3 3.7841344 up 0.000238 1448229_s_at cyclin D2 Ccnd2 3.7821527 up 0.013402 1435658_at solute carrier family 27 (fatty acid transporter), member 1 Slc27a1 3.7739747 up 0.005519 1416986_a_at signal-regulatory protein alpha Sirpa 3.771679 down 0.000099 1416035_at hypoxia inducible factor 1, alpha subunit Hif1a 3.771031 up 0.000113 1456246_x_at trophoblast specific protein beta Tpbpb 3.7703454 down 0.000109 1443920_at coiled-coil domain containing 66 Ccdc66 3.7687855 up 0.000982 1455079_at DCN1, defective in cullin neddylation 1, domain containing 4 (S. cerevisiae) Dcun1d4 3.7527087 up 0.000072 1433906_at retinaldehyde binding protein 1-like 1 Rlbp1l1 3.7497108 up 0.000962 1460116_s_at sprouty protein with EVH-1 domain 1, related sequence Spred1 3.737313 up 0.002401 1444009_at Ras association (RalGDS/AF-6) domain family 4 Rassf4 3.7354248 down 0.001259 1450022_at GTP binding protein 1 Gtpbp1 3.7307508 down 0.000395 1456264_at COMM domain containing 7 /// similar to COMM domain containing protein 7 /// similar to COMM domai Commd7 /// LOC6317 3.7285998 up 0.000041 1417293_at heparan sulfate 6-O-sulfotransferase 1 /// similar to heparan sulfate 6-sulfotransferase 1 Hs6st1 /// LOC10004 3.7232182 up 0.000325 1458417_at jumonji domain containing 1B Jmjd1b 3.7198327 up 0.017668 1438962_s_at DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 31 Ddx31 3.7016912 up 0.000003 1439238_at unc-84 homolog B (C. elegans) Unc84b 3.6819682 up 0.000431 1451069_at proviral integration site 3 Pim3 3.680863 up 0.000263 1459977_x_at COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) Cox10 3.6802485 down 0.000462 1429430_at protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 Pcmtd1 3.668768 up 0.000097 1416273_at tumor necrosis factor, alpha-induced protein 2 Tnfaip2 3.6643858 up 0.030537 1455197_at Rho family GTPase 1 Rnd1 3.65845 up 0.000007 1424155_at fatty acid binding protein 4, adipocyte Fabp4 3.6478643 up 0.001059 1447878_s_at fibroblast growth factor receptor-like 1 /// similar to fibroblast growth factor receptor 5 beta Fgfrl1 /// LOC100046 3.6387823 up 0.000001 1452110_at 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Mtrr 3.636396 up 0.000458 1455175_at PHD finger protein 13 Phf13 3.6288786 up 0.000017 1430904_at ADP-ribosylation factor GTPase activating protein 3 Arfgap3 3.6232643 up 0.026166 1436818_a_at Musashi homolog 2 (Drosophila) Msi2 3.6221836 up 0.000354 1434110_x_at major urinary protein 1 /// major urinary protein 2 /// RIKEN cDNA 2610016E04 gene /// similar to Major 2610016E04Rik /// LO 3.619854 up 0.021042 1451895_a_at 24-dehydrocholesterol reductase Dhcr24 3.614447 up 0.000052 1434282_at inhibitor of Bruton agammaglobulinemia tyrosine kinase Ibtk 3.6138272 down 0.009432 1421028_a_at myocyte enhancer factor 2C Mef2c 3.6124933 down 0.000519 1449149_at Tnf receptor-associated factor 3 Traf3 3.6102803 up 0.000076 1447122_at Proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 Psmd1 3.6083095 up 0.007986 1455278_at WD repeat domain 37 Wdr37 3.607228 up 0.001378 1428804_at microfibrillar-associated protein 3-like Mfap3l 3.601729 up 0.014433 1456394_at RAD50 interactor 1 Rint1 3.5872276 up 0.000326 1426415_a_at tripartite motif protein 25 Trim25 3.5797067 up 0.016764 1447894_x_at vacuolar protein sorting 52 (yeast) /// H2A histone family, member B3 H2afb3 /// Vps52 3.5759828 up 0.000024 1416889_at troponin I, skeletal, fast 2 Tnni2 3.5729358 down 0.000354 1434580_at ectonucleotide pyrophosphatase/phosphodiesterase 4 Enpp4 3.5709703 up 0.001290 1451461_a_at aldolase 3, C isoform Aldoc 3.5626538 up 0.001356 1452678_a_at cysteine conjugate-beta lyase 1 Ccbl1 3.5590534 down 0.002878 1436833_x_at tubulin tyrosine ligase-like 1 Ttll1 3.5538597 up 0.002240 1428936_at ATPase, Ca++ transporting, plasma membrane 1 Atp2b1 3.553 down 0.002270 1453470_a_at guanine nucleotide binding protein, alpha 13 Gna13 3.5420778 down 0.014098 1455459_at PR domain containing 15 Prdm15 3.5342648 up 0.000002 1449585_at interleukin 1 receptor accessory protein Il1rap 3.528821 up 0.009671 1435683_a_at ATP-binding cassette, sub-family C (CFTR/MRP), member 5 Abcc5 3.5244825 up 0.001157 1417671_at selenocysteine lyase Scly 3.524063 up 0.000044 1418431_at kinesin family member 5B Kif5b 3.5206368 down 0.003105 1449868_at T-box 6 Tbx6 3.5191622 up 0.004120 1421274_at suppressor of cytokine signaling 4 Socs4 3.518708 up 0.001390 1418069_at apolipoprotein C-II Apoc2 3.5185256 down 0.000086 1444760_at nuclear receptor co-repressor 1 Ncor1 3.5170193 up 0.008789 1425514_at phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) Pik3r1 3.5113633 up 0.003413 1451601_a_at spinster homolog 2 (Drosophila) Spns2 3.508696 up 0.000255 1439550_at Zinc finger protein 469 Zfp469 3.5074067 up 0.008699 1421839_at ATP-binding cassette, sub-family A (ABC1), member 1 Abca1 3.504243 down 0.014684 1422528_a_at zinc finger protein 36, C3H type-like 1 Zfp36l1 3.4989254 up 0.000215 1435275_at cytochrome c oxidase subunit VIb polypeptide 2 Cox6b2 3.4832053 down 0.000521 1459782_x_at ATP-binding cassette, sub-family C (CFTR/MRP), member 5 Abcc5 3.4811072 up 0.000013 1456420_at AT rich interactive domain 4A (Rbp1 like) Arid4a 3.4694061 down 0.000519 1453718_at BCL2-like 12 (proline rich) Bcl2l12 3.4676096 down 0.005225 1423176_at transducer of ErbB-2.1 Tob1 3.4647021 up 0.000521 1439772_at DNA segment, Chr 1, Brigham & Women's Genetics 0212 expressed D1Bwg0212e 3.4596603 up 0.003069 1450816_at polymerase (DNA directed), gamma 2, accessory subunit Polg2 3.4588277 up 0.000255 1445709_at transformed mouse 3T3 cell double minute 1 Mdm1 3.4576356 up 0.000059 1416123_at cyclin D2 Ccnd2 3.4565856 down 0.000635 1418126_at chemokine (C-C motif) ligand 5 Ccl5 3.4520519 down 0.002350 1424011_at aquaporin 9 Aqp9 3.4514768 down 0.000671 1436071_at ankyrin repeat domain 26 Ankrd26 3.4493847 up 0.000197 1418499_a_at potassium voltage-gated channel, Isk-related subfamily, gene 3 Kcne3 3.4491608 down 0.008642 1423362_at sortilin 1 Sort1 3.4416606 up 0.000032 1449303_at sestrin 3 Sesn3 3.4407976 up 0.000270 1417158_at ZXD family zinc finger C Zxdc 3.4394648 up 0.001377 1460003_at expressed sequence AI956758 AI956758 3.4387817 up 0.015613 1435458_at proviral integration site 1 Pim1 3.436966 up 0.001450 1434834_at suppressor of cytokine signaling 7 Socs7 3.436299 up 0.003168 1445724_at IQ motif containing GTPase activating protein 1 Iqgap1 3.436087 up 0.009436 1444559_at Putative homeodomain transcription factor 2 Phtf2 3.41915 up 0.000005 1416390_at regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 Rcbtb2 3.4168477 up 0.004046 1430038_at gephyrin Gphn 3.4160144 up 0.001249 1454842_a_at UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 2 B3galnt2 3.4081 up 0.004763 1434949_at armadillo repeat containing 8 Armc8 3.4057183 up 0.011531 1430008_x_at spermatogenesis associated glutamate (E)-rich protein 5, pseudogene 1 Speer5-ps1 3.4042852 down 0.001928 1426772_x_at T-cell receptor beta, joining region Tcrb-J 3.4010737 down 0.018391 1419569_a_at interferon-stimulated protein Isg20 3.3991024 down 0.015035 1448714_at RNA guanylyltransferase and 5'-phosphatase Rngtt 3.3958142 up 0.000001 1430309_at Nipped-B homolog (Drosophila) Nipbl 3.3898711 down 0.008088 1438496_a_at DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B Ddx26b 3.3865206 down 0.025045 1432344_a_at amyloid beta (A4) precursor-like protein 2 Aplp2 3.3865194 down 0.004153 1454976_at superoxide dismutase 2, mitochondrial Sod2 3.384474 up 0.000012 1451956_a_at opioid receptor, sigma 1 Oprs1 3.3805275 down 0.000107 1450155_at integrin alpha 4 Itga4 3.3801074 down 0.000059 1444233_at G protein-coupled receptor 132 Gpr132 3.377109 up 0.001734 1425506_at myosin, light polypeptide kinase Mylk 3.3684063 up 0.027847 1435980_x_at wingless-related MMTV integration site 6 Wnt6 3.3660557 down 0.007657 1448110_at sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domainSema4a 3.3633988 down 0.000572 1435176_a_at inhibitor of DNA binding 2 Id2 3.3601432 up 0.000023 1430522_a_at vesicle-associated membrane protein 5 Vamp5 3.3589995 up 0.000022 1450629_at LIM domain and actin binding 1 Lima1 3.35684 up 0.000802 1425417_x_at killer cell lectin-like receptor, subfamily A, member 8 /// similar to killer cell lectin-like receptor subfamily Klra8 /// LOC1000388 3.3564327 down 0.011093 1458350_at Optic atrophy 3 (human) Opa3 3.3479767 up 0.000001 1423350_at suppressor of cytokine signaling 5 Socs5 3.3399162 up 0.000137 1439902_at complement component 5a receptor 1 C5ar1 3.3385322 up 0.000207 1449996_a_at tropomyosin 3, gamma Tpm3 3.3355918 down 0.000266 1442256_at protein kinase C, delta Prkcd 3.3345246 up 0.000197 1456059_at proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 Psmd11 3.3332167 up 0.013479 1448951_at tumor necrosis factor receptor superfamily, member 1b Tnfrsf1b 3.331339 down 0.000021 1427164_at interleukin 13 receptor, alpha 1 Il13ra1 3.3256886 down 0.000025 1442319_at ubiquitin specific peptidase 4 (proto-oncogene) Usp4 3.3251677 up 0.031583 1437638_at serine/arginine repetitive matrix 2 Srrm2 3.3245006 up 0.005244 1452179_at PHD finger protein 17 Phf17 3.3194926 up 0.008845 1436869_at sonic hedgehog Shh 3.3171554 up 0.006789 1456378_s_at F-box and leucine-rich repeat protein 20 Fbxl20 3.311178 up 0.000871 1430388_a_at sulfatase 2 Sulf2 3.3110116 down 0.001362 1440254_at hypothetical protein LOC100041277 /// hypothetical protein LOC100045398 LOC100041277 /// LO 3.2968667 down 0.000301 1455387_at nuclear fragile X mental retardation protein interacting protein 2 Nufip2 3.2876468 up 0.000127 1421186_at chemokine (C-C motif) receptor 2 Ccr2 3.2832642 down 0.001370 1448182_a_at CD24a antigen Cd24a 3.279169 down 0.032368 1423389_at MAD homolog 7 (Drosophila) Smad7 3.2676444 up 0.001091 1423608_at integral membrane protein 2A Itm2a 3.2672167 down 0.000738 1449186_at BCL2-associated athanogene 4 Bag4 3.265973 up 0.000032 1433662_s_at tissue inhibitor of metalloproteinase 2 Timp2 3.2649822 down 0.002371 1455260_at ligand dependent nuclear receptor corepressor-like Lcorl 3.2635558 up 0.000746 1452757_s_at hemoglobin alpha, adult chain 1 /// hemoglobin alpha, adult chain 2 Hba-a1 /// Hba-a2 3.2627835 down 0.000834 1455740_at heterogeneous nuclear ribonucleoprotein A1 Hnrpa1 3.260959 up 0.000289 1458414_at DNA segment, Chr 2, ERATO Doi 93, expressed D2Ertd93e 3.2593012 up 0.000199 1429428_at transcription factor 7-like 2, T-cell specific, HMG-box Tcf7l2 3.2549617 up 0.003944 1422062_at macrophage scavenger receptor 1 Msr1 3.2526226 down 0.008061 1423747_a_at pyruvate dehydrogenase kinase, isoenzyme 1 Pdk1 3.2483628 up 0.001910 1438857_x_at interleukin-1 receptor-associated kinase 1 Irak1 3.2475019 up 0.000209 1450666_s_at ataxin 10 Atxn10 3.2471466 up 0.000010 1436089_at integrator complex subunit 6 Ints6 3.243225 up 0.003667 1455945_at zinc finger protein 817 Zfp817 3.240764 up 0.000229 1439033_at zinc finger, CCHC domain containing 7 Zcchc7 3.2404287 down 0.001593 1440255_at MBD2-interacting zinc finger /// similar to MBD2-interacting zinc finger LOC100045760 /// Mi 3.2383 up 0.000006 1418913_at betaine-homocysteine methyltransferase 2 Bhmt2 3.2368555 down 0.005405 1435927_at DENN/MADD domain containing 3 Dennd3 3.234925 up 0.015084 1440403_at Rho guanine nucleotide exchange factor (GEF) 1 Arhgef1 3.2286208 up 0.001615 1450495_a_at killer cell lectin-like receptor subfamily K, member 1 Klrk1 3.2250328 down 0.013377 1430058_at stem-loop binding protein Slbp 3.224584 up 0.000154 1459597_at myotrophin Mtpn 3.2244744 up 0.000007 1451869_at ATP-binding cassette, sub-family A (ABC1), member 3 Abca3 3.2232907 up 0.002569 1420170_at myosin, heavy polypeptide 9, non-muscle Myh9 3.2221391 up 0.000034 1435087_at cDNA sequence BC039093 BC039093 3.2208507 up 0.000008 1449454_at bone marrow stromal cell antigen 1 Bst1 3.219862 up 0.025758 1429123_at RAB27A, member RAS oncogene family Rab27a 3.2180395 up 0.000421 1451867_x_at Rho GTPase activating protein 6 Arhgap6 3.2150457 up 0.000112 1452690_at KH-type splicing regulatory protein Khsrp 3.2148278 up 0.000789 1455853_x_at tetraspanin 31 Tspan31 3.2141697 down 0.011427 1415728_at poly(A) binding protein, nuclear 1 Pabpn1 3.2118638 up 0.000385 1416513_at laminin, beta 2 Lamb2 3.2116168 down 0.001585 1431196_at ATPase, Ca++-sequestering Atp2c1 3.2103088 down 0.000993 1434690_at lysocardiolipin acyltransferase Lycat 3.2068782 up 0.000207 1425627_x_at glutathione S-transferase, mu 1 /// similar to Glutathione S-transferase Mu 1 (GST class-mu 1) (Glutathi Gstm1 /// LOC100043 3.2040768 up 0.000119 1443867_at ankyrin repeat domain 12 Ankrd12 3.2039115 down 0.000153 1439759_x_at sulfotransferase family, cytosolic, 6B, member 1 Sult6b1 3.1964684 down 0.000727 1425609_at neutrophil cytosolic factor 1 Ncf1 3.194353 down 0.000789 1450644_at zinc finger protein 36, C3H type-like 1 Zfp36l1 3.194298 up 0.000017 1436882_at ubiquitin-like 5 Ubl5 3.1923604 up 0.007122 1440355_at potassium channel tetramerisation domain containing 12b Kctd12b 3.190468 up 0.000050 1450058_at aspartate-beta-hydroxylase Asph 3.1891057 up 0.000508 1459751_s_at protein phosphatase 1, regulatory (inhibitor) subunit 16A Ppp1r16a 3.1878812 up 0.002519 1431189_a_at fumarylacetoacetate hydrolase domain containing 2A Fahd2a 3.1851776 down 0.002088 1428166_at congenital dyserythropoietic anemia, type I (human) Cdan1 3.1843703 up 0.000153 1452846_at protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 Ppfia4 3.1832821 down 0.000045 1437614_x_at zinc finger, DHHC domain containing 14 Zdhhc14 3.180555 up 0.022092 1444908_at hyaluronic acid binding protein 4 Habp4 3.1769116 up 0.000270 1447724_x_at Optic atrophy 3 (human) Opa3 3.173374 up 0.000088 1438625_s_at PCTAIRE-motif protein kinase 1 Pctk1 3.1637871 up 0.000002 1426913_at lanosterol synthase Lss 3.1597638 up 0.007361 1437304_at Casitas B-lineage lymphoma b Cblb 3.1524296 up 0.014318 1452005_at dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) Dlat 3.1494207 up 0.000115 1434070_at jagged 1 Jag1 3.1471295 up 0.001578 1418377_a_at SIVA1, apoptosis-inducing factor Siva1 3.1459854 down 0.000053 1427013_at carbonic anhydrase 9 Car9 3.1441433 up 0.003209 1434606_at v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) Erbb3 3.1439626 up 0.000290 1439221_s_at CD40 antigen Cd40 3.1436074 down 0.000192 1448096_at 2-oxoglutarate and iron-dependent oxygenase domain containing 1 Ogfod1 3.1399386 up 0.012508 1418329_at pyroglutamyl-peptidase I Pgpep1 3.1398284 up 0.000009 1419513_a_at ect2 oncogene Ect2 3.1358771 up 0.029650 1416148_at lysosomal-associated protein transmembrane 4B Laptm4b 3.1353133 up 0.005331 1416326_at cysteine-rich protein 1 (intestinal) Crip1 3.1307333 down 0.000282 1420115_at exosome component 8 Exosc8 3.1299677 up 0.000129 1447667_x_at mitogen activated protein kinase kinase kinase 4 Map3k4 3.1265194 up 0.000078 1453197_at mediator of RNA polymerase II transcription, subunit 25 homolog (yeast) Med25 3.1259646 up 0.000389 1455580_at USP6 N-terminal like Usp6nl 3.1255636 up 0.000338 1446272_at PCTAIRE-motif protein kinase 2 Pctk2 3.1181593 down 0.032694 1419678_at large tumor suppressor 2 Lats2 3.1123664 down 0.000030 1422817_at glycoprotein 5 (platelet) Gp5 3.110702 up 0.017717 1416481_s_at HIG1 domain family, member 1A Higd1a 3.109952 up 0.001330 1419568_at mitogen activated protein kinase 1 Mapk1 3.1060238 up 0.001603 1460639_a_at ATX1 (antioxidant protein 1) homolog 1 (yeast) Atox1 3.105599 down 0.000077 1452385_at ubiquitin specific peptidase 53 Usp53 3.1044037 up 0.000897 1443242_at DNA segment, Chr 5, ERATO Doi 121, expressed D5Ertd121e 3.10277 up 0.001524 1452205_x_at T-cell receptor beta, variable 13 Tcrb-V13 3.102156 down 0.003253 1446424_at dynein, axonemal, heavy chain 7-like Dnahc7l 3.1007342 down 0.003850 1426856_at hydroxysteroid dehydrogenase like 2 Hsdl2 3.0966887 up 0.002686 1456358_at ets variant gene 3 Etv3 3.0964327 up 0.000185 1435592_at eukaryotic translation initiation factor 5B Eif5b 3.0964062 up 0.004781 1435292_at TBC1 domain family, member 4 Tbc1d4 3.092114 up 0.006318 1434454_at DNA segment, Chr 16, Wayne State University 65, expressed D16Wsu65e 3.0909643 down 0.000402 1437939_s_at cathepsin C Ctsc 3.0860503 down 0.002857 1433905_at A kinase (PRKA) anchor protein 7 Akap7 3.0858197 up 0.007910 1445292_at CD300A antigen Cd300a 3.082143 up 0.000381 1417461_at CAP, adenylate cyclase-associated protein 1 (yeast) Cap1 3.0803466 up 0.026372 1451285_at fusion, derived from t(12;16) malignant liposarcoma (human) Fus 3.0776966 up 0.000008 1437775_at dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) Dlst 3.0760186 up 0.000513 1425229_a_at transcription factor 7-like 2, T-cell specific, HMG-box Tcf7l2 3.073096 up 0.007305 1458969_at expressed sequence AU019559 AU019559 3.0712218 up 0.006566 1459998_at zinc finger protein 407 Zfp407 3.0656517 up 0.002943 1458941_at zinc finger E-box binding homeobox 2 Zeb2 3.0628605 down 0.004900 1446344_at nyctalopin Nyx 3.06122 up 0.000354 1447780_x_at Tu translation elongation factor, mitochondrial /// similar to Tu translation elongation factor, mitochondriaLOC100041265 /// LO 3.0600605 up 0.000333 1456117_at ribosomal RNA processing 1 homolog B (S. cerevisiae) Rrp1b 3.0566733 up 0.005068 1416852_a_at neurochondrin Ncdn 3.0536923 up 0.000133 1448076_at Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) Ctr9 3.052778 up 0.008333 1460589_at zinc finger protein 597 Zfp597 3.0497334 up 0.002392 1423693_at elastase 1, pancreatic Ela1 3.049248 up 0.001198 1420610_at protein kinase, cAMP dependent, catalytic, beta Prkacb 3.048775 down 0.000414 1445242_at glycerol kinase Gyk 3.047859 up 0.001027 1427692_a_at calcium/calmodulin-dependent serine protein kinase (MAGUK family) Cask 3.0457675 down 0.000810 1430317_at ubiquitin-conjugating enzyme E2, J2 homolog (yeast) Ube2j2 3.045397 up 0.000627 1454823_at WD repeat domain 37 Wdr37 3.042399 down 0.000924 1437986_x_at fucokinase Fuk 3.0420008 up 0.000264 1429526_at bromodomain containing 8 Brd8 3.041288 up 0.031542 1433436_s_at thiamine triphosphatase /// zinc finger homeobox 2, antisense Thtpa /// Zfhx2as 3.039861 up 0.000387 1427311_at bromodomain PHD finger transcription factor Bptf 3.0273893 down 0.005198 1418371_at dynein light chain LC8-type 2 Dynll2 3.0272498 up 0.001513 1436332_at heat shock protein, alpha-crystallin-related, B6 Hspb6 3.0261538 up 0.000294 1430802_at histocompatibility 2, Q region locus 8 /// hypothetical protein LOC100044307 H2-Q8 /// LOC100044 3.0251052 up 0.019129 1449310_at prostaglandin E receptor 2 (subtype EP2) Ptger2 3.0204685 up 0.003806 1450381_a_at B-cell leukemia/lymphoma 6 Bcl6 3.0197358 down 0.000449 1430300_at SCO cytochrome oxidase deficient homolog 1 (yeast) Sco1 3.0195696 up 0.022721 1459771_x_at phytoceramidase, alkaline Phca 3.0170293 down 0.003033 1454890_at angiomotin Amot 3.014654 up 0.000423 1436479_a_at dipeptidylpeptidase 7 Dpp7 3.014333 up 0.008991 1425067_at cadherin EGF LAG seven-pass G-type receptor 3 Celsr3 3.0122247 up 0.031528 1421375_a_at S100 calcium binding protein A6 (calcyclin) S100a6 3.0107067 down 0.000081 1421239_at interleukin 6 signal transducer Il6st 3.0104163 down 0.007634 1418932_at nuclear factor, interleukin 3, regulated /// similar to NFIL3/E4BP4 transcription factor LOC100046232 /// Nf 3.01005 up 0.021942 1451177_at DnaJ (Hsp40) homolog, subfamily B, member 4 Dnajb4 3.009306 up 0.000481 1450631_x_at defensin related cryptdin 12 /// defensin related cryptdin 15 /// defensin related cryptdin 25 /// defensin reDefa-ps1 /// Defcr12 3.0057821 down 0.001973 1435316_at Proteasome (prosome, macropain) subunit, alpha type 6 Psma6 3.0044978 up 0.005112 1435469_at quiescin Q6 sulfhydryl oxidase 2 Qsox2 3.0011492 up 0.000526 1450214_at adenosine A2b receptor /// similar to Adenosine A2b receptor Adora2b /// LOC1000 3.000796 down 0.001176 1437812_x_at alpha glucosidase 2 alpha neutral subunit Ganab 2.9993632 down 0.002586 1421217_a_at lectin, galactose binding, soluble 9 Lgals9 2.9878895 down 0.001376 1424092_at erythrocyte protein band 4.1 Epb4.1 2.9863386 down 0.023951 1423600_a_at Treacher Collins Franceschetti syndrome 1, homolog Tcof1 2.9859498 down 0.004089 1426686_s_at mitogen activated protein kinase kinase kinase 3 Map3k3 2.9842508 up 0.000865 1450407_a_at acidic (leucine-rich) nuclear phosphoprotein 32 family, member A Anp32a 2.9839509 down 0.000694 1452431_s_at histocompatibility 2, class II antigen A, alpha H2-Aa 2.9837852 down 0.000114 1425007_at zinc finger protein 566 Zfp566 2.9819465 up 0.007537 1448061_at macrophage scavenger receptor 1 Msr1 2.9806201 down 0.007807 1434222_at signal-induced proliferation-associated 1 like 1 Sipa1l1 2.9803867 up 0.008382 1435676_at centrosomal protein 164 Cep164 2.9742718 up 0.023753 1421922_at SH3-domain binding protein 5 (BTK-associated) Sh3bp5 2.971537 up 0.000381 1447264_at RAB11 family interacting protein 1 (class I) Rab11fip1 2.9694557 up 0.022544 1416112_at cytochrome c oxidase, subunit VIIIa Cox8a 2.9691918 down 0.000167 1437763_at DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae) Dcun1d3 2.9687736 up 0.003236 1459885_s_at cytochrome c oxidase, subunit VIIc /// similar to cytochrome c oxidase, subunit VIIc Cox7c /// LOC100041 2.9674513 up 0.005482 1428224_at heterogeneous nuclear ribonucleoprotein D-like Hnrpdl 2.965461 up 0.002769 1429914_at enhancer of polycomb homolog 1 (Drosophila) Epc1 2.9603627 up 0.011557 1440459_at senataxin Setx 2.9603403 up 0.000882 1416868_at cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) Cdkn2c 2.960132 up 0.002436 1451767_at neutrophil cytosolic factor 1 Ncf1 2.9595213 down 0.000046 1442004_at tripartite motif-containing 65 Trim65 2.9588926 up 0.001477 1439376_x_at cyclin D binding myb-like transcription factor 1 Dmtf1 2.9564817 down 0.011239 1427958_at abhydrolase domain containing 10 Abhd10 2.9552493 up 0.000004 1435914_at nuclear receptor co-repressor 1 Ncor1 2.9542654 up 0.002045 1421989_s_at 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Papss2 2.9524157 down 0.000009 1439370_x_at splicing factor 3b, subunit 5 Sf3b5 2.9517453 down 0.002440 1433756_at S100P binding protein S100pbp 2.951435 up 0.000332 1424118_a_at SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) Spc25 2.945772 up 0.009036 1416180_a_at radixin Rdx 2.94551 down 0.006623 1442145_at ATPase type 13A3 Atp13a3 2.9404345 up 0.001492 1416689_at tuftelin 1 Tuft1 2.9404054 up 0.000700 1437410_at aldehyde dehydrogenase 2, mitochondrial Aldh2 2.9388595 up 0.000056 1453313_at sestrin 3 Sesn3 2.9371216 up 0.032006 1455608_at sodium channel and clathrin linker 1 Sclt1 2.934514 up 0.000279 1440914_s_at aftiphilin Aftph 2.931567 up 0.000247 1438975_x_at zinc finger, DHHC domain containing 14 Zdhhc14 2.9291668 up 0.000011 1438920_x_at Complement receptor related protein Crry 2.9283237 up 0.000280 1415893_at sphingosine phosphate lyase 1 Sgpl1 2.924368 down 0.000931 1440778_x_at Zinc finger protein 712 Zfp712 2.9237976 up 0.017632 1415904_at lipoprotein lipase Lpl 2.9196827 up 0.000541 1429427_s_at transcription factor 7-like 2, T-cell specific, HMG-box Tcf7l2 2.918938 up 0.002775 1430028_at RIKEN cDNA 2210018M11 gene 2210018M11Rik 2.9188423 up 0.008786 1422703_at glycerol kinase Gyk 2.9141374 up 0.004032 1443932_at kelch domain containing 1 Klhdc1 2.908838 up 0.006288 1460633_at PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae) Prpf19 2.907229 up 0.000199 1452041_at kelch-like 26 (Drosophila) Klhl26 2.9042747 up 0.001273 1416375_at adaptor-related protein complex 3, mu 1 subunit /// similar to Adapter-related protein complex 3 mu 1 suAp3m1 /// LOC63632 2.9035685 up 0.009904 1435484_at expressed sequence BF642829 BF642829 2.9021647 up 0.000201 1449993_at vesicle-associated membrane protein 5 Vamp5 2.9008 up 0.005113 1418912_at plexin domain containing 2 Plxdc2 2.90043 up 0.004835 1457282_x_at Tubulin, gamma complex associated protein 5 Tubgcp5 2.8998322 down 0.005472 1438520_at solute carrier family 25, member 36 Slc25a36 2.8983219 up 0.008978 1423489_at monocyte to macrophage differentiation-associated /// similar to monocyte to macrophage differentiationLOC100047565 /// Mm 2.8970642 up 0.007388 1442367_at Atpase, class VI, type 11C Atp11c 2.893252 down 0.000794 1451901_at helicase-like transcription factor Hltf 2.8913562 up 0.006534 1419879_s_at tripartite motif protein 25 Trim25 2.8912904 up 0.003113 1417704_a_at Rho GTPase activating protein 6 Arhgap6 2.8911517 up 0.000277 1455765_a_at ATP-binding cassette, sub-family C (CFTR/MRP), member 8 Abcc8 2.890501 down 0.001419 1426093_at tripartite motif protein 34 Trim34 2.8879485 up 0.001880 1446457_at DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 Ddx58 2.8850415 up 0.029318 1443323_at coiled-coil domain containing 76 Ccdc76 2.8822718 up 0.001444 1435912_at UBX domain containing 7 Ubxd7 2.8803806 up 0.020748 1430045_at translin-associated factor X Tsnax 2.8798246 up 0.016120 1457024_x_at solute carrier family 35 (UDP-galactose transporter), member A2 Slc35a2 2.879346 up 0.008681 1434045_at cyclin-dependent kinase inhibitor 1B Cdkn1b 2.878637 up 0.000056 1423815_at DEAD (Asp-Glu-Ala-Asp) box polypeptide 56 Ddx56 2.875288 down 0.003215 1425821_at chloride channel 7 Clcn7 2.8705478 up 0.004363 1421413_a_at PDZ and LIM domain 5 Pdlim5 2.868354 down 0.000292 1447290_at SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae) Sys1 2.867539 up 0.000009 1451608_a_at tetraspanin 33 Tspan33 2.8633652 down 0.001219 1421237_at thymopoietin Tmpo 2.8592777 down 0.007539 1449345_at coiled-coil domain containing 34 Ccdc34 2.8572838 up 0.000170 1428735_at CD69 antigen Cd69 2.8563335 up 0.012729 1456735_x_at acid phosphatase-like 2 Acpl2 2.8555284 up 0.029282 1419359_at hexamethylene bis-acetamide inducible 1 Hexim1 2.8555207 up 0.000457 1439197_at phosphatidylinositol 4-kinase, catalytic, beta polypeptide Pi4kb 2.854762 up 0.007568 1425098_at zinc finger protein 106 Zfp106 2.8532858 up 0.000176 1422805_a_at inhibitor of growth family, member 3 Ing3 2.8502762 up 0.000518 1451378_at UTP6, small subunit (SSU) processome component, homolog (yeast) Utp6 2.8499568 up 0.000082 1421027_a_at myocyte enhancer factor 2C Mef2c 2.8499353 down 0.001495 1450967_at protein tyrosine phosphatase-like A domain containing 2 Ptplad2 2.8492815 down 0.000138 1435462_at phosphatidylinositol-specific phospholipase C, X domain containing 2 Plcxd2 2.8470533 up 0.004725 1460026_s_at zinc finger, FYVE domain containing 27 Zfyve27 2.8445053 up 0.000109 1427318_s_at dysferlin /// fer-1-like 3, myoferlin (C. elegans) Dysf /// Fer1l3 2.844211 down 0.018628 1438480_a_at thymocyte nuclear protein 1 Thyn1 2.842555 down 0.000135 1449198_a_at ST3 beta-galactoside alpha-2,3-sialyltransferase 5 St3gal5 2.839095 down 0.000049 1435882_at ubiquitin associated protein 2-like Ubap2l 2.8371768 up 0.000076 1426345_at prolyl endopeptidase-like Prepl 2.8351858 up 0.000997 1431024_a_at AT rich interactive domain 4B (Rbp1 like) Arid4b 2.8324938 down 0.003584 1425706_a_at damage specific DNA binding protein 2 Ddb2 2.8307269 up 0.003760 1442465_s_at spermatid perinuclear RNA binding protein Strbp 2.8302863 up 0.000485 1424902_at plexin domain containing 1 Plxdc1 2.8297017 up 0.000743 1415977_at myo-inositol 1-phosphate synthase A1 Isyna1 2.8281364 up 0.000772 1416762_at S100 calcium binding protein A10 (calpactin) S100a10 2.8264554 down 0.008130 1428900_s_at methyltransferase 5 domain containing 1 Mett5d1 2.824588 up 0.009453 1451798_at interleukin 1 receptor antagonist Il1rn 2.8241982 up 0.006174 1452666_a_at transmembrane and coiled-coil domains 2 Tmcc2 2.8211718 down 0.002472 1437742_at RAB21, member RAS oncogene family Rab21 2.8204324 up 0.005059 1451282_at centaurin, delta 3 Centd3 2.819107 down 0.000221 1425854_x_at T-cell receptor beta, variable 13 Tcrb-V13 2.8188305 down 0.029166 1437051_at DNA fragmentation factor, beta subunit Dffb 2.8183079 up 0.003478 1416020_a_at ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 1 /// similar to HAtp5g1 /// LOC10004 2.8170524 down 0.000032 1435597_at ATPase family, AAA domain containing 5 Atad5 2.816527 up 0.000875 1434987_at aldehyde dehydrogenase 2, mitochondrial Aldh2 2.8160052 up 0.008260 1450241_a_at ecotropic viral integration site 2a Evi2a 2.8159482 down 0.000142 1433804_at Janus kinase 1 Jak1 2.8124845 down 0.027458 1424542_at S100 calcium binding protein A4 S100a4 2.809686 down 0.000239 1419573_a_at lectin, galactose binding, soluble 1 Lgals1 2.8057642 down 0.000325 1425974_a_at tripartite motif protein 25 Trim25 2.8048742 up 0.003300 1428052_a_at zinc finger, MYM domain containing 1 Zmym1 2.8047934 up 0.003417 1442040_at transmembrane protein 125 Tmem125 2.8046489 down 0.000043 1437953_at preimplantation protein 4 Prei4 2.8036005 up 0.001167 1422973_a_at thyroid hormone responsive SPOT14 homolog (Rattus) Thrsp 2.8006291 down 0.014415 1433799_at retinol dehydrogenase 13 (all-trans and 9-cis) Rdh13 2.7948704 up 0.000116 1456746_a_at Cd99 antigen-like 2 Cd99l2 2.7946422 down 0.002175 1426288_at low density lipoprotein receptor-related protein 4 Lrp4 2.7921088 up 0.000543 1455368_at zinc finger, DHHC domain containing 3 Zdhhc3 2.7916908 up 0.002166 1442811_at RGM domain family, member B Rgmb 2.7916188 up 0.004926 1435821_s_at protein phosphatase 1, regulatory (inhibitor) subunit 8 Ppp1r8 2.7881148 up 0.000174 1444289_at Yip1 domain family, member 5 Yipf5 2.7880154 up 0.001253 1460094_at G protein-coupled receptor 107 Gpr107 2.7879343 up 0.015502 1435441_at actin-binding LIM protein 2 Ablim2 2.786806 down 0.000160 1416330_at CD 81 antigen Cd81 2.785987 down 0.001269 1447837_x_at polymerase (DNA directed), eta (RAD 30 related) Polh 2.7840705 up 0.000233 1417132_at cell division cycle 25 homolog A (S. pombe) Cdc25a 2.78349 up 0.000290 1449645_s_at chaperonin subunit 3 (gamma) Cct3 2.7828865 down 0.001272 1458510_at expressed sequence AU019823 AU019823 2.7821562 down 0.000199 1444157_a_at jumonji, AT rich interactive domain 1C (Rbp2 like) Jarid1c 2.7801607 up 0.000395 1433758_at nischarin Nisch 2.7799878 up 0.000716 1422452_at Bcl2-associated athanogene 3 Bag3 2.778924 up 0.000107 1420852_a_at UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 B3gnt2 2.7787485 down 0.003023 1448534_at signal-regulatory protein alpha Sirpa 2.7766764 down 0.000001 1456040_at splicing factor 3b, subunit 2 Sf3b2 2.7744784 down 0.000118 1454617_at arrestin domain containing 3 Arrdc3 2.7741814 up 0.003585 1456565_s_at mitogen activated protein kinase kinase kinase 12 Map3k12 2.7714896 up 0.001850 1416521_at selenoprotein W, muscle 1 Sepw1 2.7665923 down 0.000780 1433586_at RGM domain family, member B Rgmb 2.7644563 up 0.010367 1460684_at transmembrane 7 superfamily member 2 Tm7sf2 2.7644188 up 0.007897 1433491_at erythrocyte protein band 4.1-like 2 Epb4.1l2 2.7638972 down 0.000026 1419866_s_at ataxin 2 /// similar to ataxin 2 Atxn2 /// LOC100047 2.760917 up 0.000698 1425294_at SLAM family member 8 Slamf8 2.7552094 down 0.009409 1439805_at nuclear factor of activated T-cells 5 Nfat5 2.7550793 down 0.003386 1438610_a_at crystallin, zeta Cryz 2.753315 up 0.002587 1437426_at WW domain containing adaptor with coiled-coil Wac 2.7528882 down 0.000021 1435884_at intersectin 1 (SH3 domain protein 1A) Itsn1 2.7510338 up 0.012077 1415976_a_at calcium regulated heat stable protein 1 Carhsp1 2.7500627 down 0.005704 1449121_at FUS interacting protein (serine-arginine rich) 1 Fusip1 2.7462478 up 0.002377 1458617_at protein kinase C binding protein 1 Prkcbp1 2.744893 up 0.002672 1441931_x_at glutathione synthetase Gss 2.7439044 up 0.000494 1426610_a_at transcription termination factor 1 Ttf1 2.7430491 up 0.000304 1457162_at low density lipoprotein receptor adaptor protein 1 Ldlrap1 2.7418685 up 0.000434 1437643_at centromere protein J Cenpj 2.7402291 up 0.000033 1433853_at mindbomb homolog 1 (Drosophila) Mib1 2.7399385 up 0.004185 1438016_at dyskeratosis congenita 1, dyskerin homolog (human) Dkc1 2.7381442 up 0.001089 1459667_at Rho GTPase activating protein 17 Arhgap17 2.7380383 up 0.011038 1458351_s_at kelch-like 2, Mayven (Drosophila) Klhl2 2.7376935 up 0.002697 1423902_s_at Rho guanine nucleotide exchange factor (GEF) 12 Arhgef12 2.737317 up 0.003815 1422850_at poly(A) binding protein, nuclear 1 Pabpn1 2.735426 up 0.002588 1435655_at small nucleolar RNA, H/ACA box 65 Snora65 2.7352815 up 0.007616 1449259_at RAB3D, member RAS oncogene family Rab3d 2.7338686 up 0.006187 1446145_at eukaryotic translation initiation factor 4 gamma, 3 Eif4g3 2.7337716 up 0.014087 1439319_at E74-like factor 1 Elf1 2.7335 up 0.001604 1435930_at zinc finger protein 291 Zfp291 2.7254493 up 0.001522 1439063_at additional sex combs like 2 (Drosophila) Asxl2 2.7242444 up 0.006659 1458665_at Chloride intracellular channel 1 Clic1 2.7237346 up 0.005040 1435170_at TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) Tsr2 2.7225003 up 0.002311 1436501_at mitochondrial tumor suppressor 1 Mtus1 2.7218673 down 0.006447 1434599_a_at tight junction protein 2 Tjp2 2.7217865 up 0.018054 1437271_at cardiotrophin-like cytokine factor 1 Clcf1 2.7193756 up 0.000174 1456812_at ATP-binding cassette, sub-family D (ALD), member 2 Abcd2 2.7193074 up 0.019555 1426168_a_at T-cell receptor alpha chain Tcra 2.7175345 down 0.014066 1451340_at AT rich interactive domain 5A (Mrf1 like) Arid5a 2.71351 up 0.017296 1416041_at serum/glucocorticoid regulated kinase Sgk 2.7120817 up 0.002568 1457969_at RAB interacting factor Rabif 2.7117398 up 0.001878 1426748_s_at ATP-binding cassette, sub-family F (GCN20), member 3 Abcf3 2.7096877 up 0.017487 1457623_x_at transformation related protein 53 Trp53 2.7092965 up 0.003590 1430987_s_at WW domain binding protein 11 Wbp11 2.708282 down 0.003030 1429624_at SAFB-like, transcription modulator Sltm 2.70613 down 0.000032 1437152_at mex3 homolog B (C. elegans) Mex3b 2.704751 up 0.003383 1419169_at mitogen-activated protein kinase 6 Mapk6 2.7035544 up 0.001788 1429319_at ras homolog gene family, member H Rhoh 2.702921 down 0.001831 1433633_at interferon regulatory factor 2 binding protein 2 Irf2bp2 2.70154 up 0.005659 1460164_at spindlin 1 /// similar to Spindlin 1 LOC100046080 /// Sp 2.7006626 up 0.002391 1426604_at ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent) Rnasel 2.7004197 up 0.000142 1455578_x_at ribosomal protein L41 Rpl41 2.700311 down 0.000528 1454030_at SAPS domain family, member 3 Saps3 2.6985304 down 0.011125 1436368_at solute carrier family 16 (monocarboxylic acid transporters), member 10 Slc16a10 2.696654 up 0.000056 1421923_at SH3-domain binding protein 5 (BTK-associated) Sh3bp5 2.6964777 up 0.001782 1452882_at progesterone receptor membrane component 2 Pgrmc2 2.6949763 up 0.000614 1455395_at 3-oxoacyl-ACP synthase, mitochondrial Oxsm 2.6926355 up 0.000304 1435625_at ectonucleoside triphosphate diphosphohydrolase 7 Entpd7 2.691776 up 0.000275 1425749_at syntaxin binding protein 6 (amisyn) Stxbp6 2.6894958 down 0.008530 1420928_at beta galactoside alpha 2,6 sialyltransferase 1 St6gal1 2.6889393 down 0.007894 1448733_at Bmi1 polycomb ring finger oncogene Bmi1 2.6863172 up 0.000756 1436526_at N-acetylglucosamine-1-phosphotransferase, gamma subunit Gnptg 2.6862292 down 0.000385 1431166_at chromodomain helicase DNA binding protein 1 Chd1 2.6855369 up 0.022185 1420968_at BTB (POZ) domain containing 14B Btbd14b 2.6839678 down 0.003123 1434142_at protein phosphatase 1D magnesium-dependent, delta isoform /// similar to Protein phosphatase 1D magLOC100045551 /// Pp 2.683511 up 0.009633 1439050_at expressed sequence AI649393 AI649393 2.6832654 up 0.005089 1452011_a_at UDP-glucuronate decarboxylase 1 Uxs1 2.68222 up 0.000508 1460205_at dephospho-CoA kinase domain containing Dcakd 2.6818664 up 0.003204 1429943_at chitobiase, di-N-acetyl- Ctbs 2.6804652 up 0.013859 1438075_at fem-1 homolog c (C.elegans) Fem1c 2.6775715 up 0.002566 1423653_at ATPase, Na+/K+ transporting, alpha 1 polypeptide Atp1a1 2.6773787 down 0.000467 1437711_x_at ornithine decarboxylase, structural 1 /// similar to Ornithine decarboxylase (ODC) /// similar to Odc1 prot EG666231 /// EG6683 2.6773167 up 0.009958 1425551_at huntingtin interacting protein 1 related Hip1r 2.6742568 up 0.000096 1420818_at src-like adaptor Sla 2.6724842 down 0.000553 1427902_at serine/arginine repetitive matrix 2 /// similar to Serine/arginine repetitive matrix protein 2 LOC100046744 /// Sr 2.671949 up 0.000019 1428853_at patched homolog 1 Ptch1 2.6718447 up 0.014613 1435388_at NADPH dependent diflavin oxidoreductase 1 /// similar to ring finger protein 183 LOC100039232 /// Nd 2.6713672 up 0.004341 1453302_at transmembrane protein 81 Tmem81 2.6688554 up 0.023751 1436327_a_at vacuolar protein sorting 53 (yeast) Vps53 2.6676586 down 0.000164 1448699_at mitochondrial ribosomal protein L54 Mrpl54 2.6667137 down 0.000004 1421857_at a disintegrin and metallopeptidase domain 17 Adam17 2.6651382 down 0.000331 1421303_at IKAROS family zinc finger 1 Ikzf1 2.6647382 down 0.000638 1457139_at Autism susceptibility candidate 2 Auts2 2.6640399 down 0.001153 1425865_a_at ligase III, DNA, ATP-dependent Lig3 2.6620605 down 0.003674 1420620_a_at ring finger protein 13 Rnf13 2.6620076 down 0.000375 1437502_x_at CD24a antigen Cd24a 2.6601799 down 0.029880 1448710_at chemokine (C-X-C motif) receptor 4 Cxcr4 2.6601183 up 0.003154 1447363_s_at budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) Bub1b 2.6593096 up 0.002575 1448437_a_at GTP binding protein 2 Gtpbp2 2.6533551 up 0.000011 1425314_at G protein-coupled receptor 98 Gpr98 2.6512382 up 0.000686 1417898_a_at granzyme A Gzma 2.6492217 down 0.032327 1459835_s_at DnaJ (Hsp40) homolog, subfamily A, member 1 Dnaja1 2.6488285 up 0.002173 1448357_at small nuclear ribonucleoprotein polypeptide G Snrpg 2.6441891 down 0.000070 1424711_at transmembrane protein 2 Tmem2 2.6426733 up 0.009336 1418435_at makorin, ring finger protein, 1 Mkrn1 2.642384 down 0.008819 1435798_a_at splicing factor, arginine/serine-rich 14 Sfrs14 2.6409032 up 0.000169 1460710_at adenosine A2a receptor Adora2a 2.6393554 down 0.017053 1422316_at glycoprotein 1b, alpha polypeptide /// hypothetical protein LOC100048807 Gp1ba /// LOC100048 2.637369 up 0.024221 1457691_at Epstein-Barr virus induced gene 2 Ebi2 2.63715 down 0.002393 1455960_at multiple EGF-like-domains 9 Megf9 2.6371396 down 0.026128 1424603_at sulfatase modifying factor 1 Sumf1 2.6347742 up 0.001118 1439755_at Signal-induced proliferation-associated 1 like 1 Sipa1l1 2.634642 up 0.012068 1418427_at kinesin family member 5B Kif5b 2.6339521 down 0.000393 1459800_s_at mitogen activated protein kinase kinase kinase 4 Map3k4 2.6323214 up 0.000268 1436545_at deltex 4 homolog (Drosophila) Dtx4 2.6311104 up 0.001840 1451358_a_at Rac GTPase-activating protein 1 Racgap1 2.629722 down 0.000793 1436994_a_at histone cluster 1, H1c Hist1h1c 2.6288261 up 0.000772 1437840_s_at similar to galactose 3-O-sulfotransferase-2 LOC100041596 2.6282074 up 0.001057 1455698_at translocation protein 1 Tloc1 2.6276257 up 0.001881 1419935_s_at similar to casein kinase II, alpha prime subunit LOC100046483 2.6271715 up 0.000731 1426601_at solute carrier family 37 (glycerol-3-phosphate transporter), member 1 Slc37a1 2.6260777 up 0.030298 1430171_at fibroblast growth factor (acidic) intracellular binding protein Fibp 2.6257243 up 0.003930 1425305_at zinc finger protein 295 Zfp295 2.6256497 up 0.014237 1419604_at Z-DNA binding protein 1 Zbp1 2.6243517 up 0.016986 1416333_at docking protein 2 Dok2 2.6240795 down 0.011998 1431030_a_at ring finger protein 14 Rnf14 2.6237707 down 0.023930 1450006_at nuclear receptor coactivator 4 /// predicted gene, EG627557 EG627557 /// Ncoa4 2.623389 down 0.002273 1435836_at pyruvate dehydrogenase kinase, isoenzyme 1 Pdk1 2.6229937 up 0.003995 1429722_at zinc finger and BTB domain containing 4 Zbtb4 2.6228273 up 0.002612 1429246_a_at annexin A6 Anxa6 2.6224763 down 0.000208 1427135_at splicing factor, arginine/serine-rich 12 Sfrs12 2.6223662 down 0.032399 1417740_at cell division cycle 37 homolog (S. cerevisiae)-like 1 Cdc37l1 2.6219242 up 0.000852 1453550_a_at male sterility domain containing 2 Mlstd2 2.62114 down 0.017871 1453573_at histone cluster 1, H3d Hist1h3d 2.6195624 up 0.002037 1455979_at AT rich interactive domain 1B (Swi1 like) Arid1b 2.619556 up 0.000487 1429555_at claudin domain containing 1 Cldnd1 2.6175585 up 0.006065 1433664_at ubiquitin-conjugating enzyme E2Q (putative) 2 Ube2q2 2.617304 up 0.000560 1423129_at soc-2 (suppressor of clear) homolog (C. elegans) Shoc2 2.6134832 up 0.001492 1426406_at SET domain containing (lysine methyltransferase) 8 Setd8 2.613359 up 0.000074 1449420_at phosphodiesterase 1B, Ca2+-calmodulin dependent Pde1b 2.613243 up 0.000307 1452831_s_at phosphoribosyl pyrophosphate amidotransferase Ppat 2.6100018 up 0.001322 1422704_at glycerol kinase Gyk 2.609661 up 0.001915 1436955_at tumor suppressing subtransferable candidate 1 Tssc1 2.608347 up 0.000501 1417219_s_at thymosin, beta 10 /// hypothetical protein LOC100042319 /// hypothetical protein LOC100045828 LOC100042319 /// LO 2.604188 down 0.000050 1418834_at cappuccino Cno 2.6031184 up 0.000714 1441830_x_at A kinase (PRKA) anchor protein 10 Akap10 2.600688 down 0.005246 1420485_at nucleolar protein 7 Nol7 2.6005266 up 0.000937 1424242_at biphenyl hydrolase-like (serine hydrolase, breast epithelial mucin-associated antigen) Bphl 2.600094 up 0.000000 1458023_at G patch domain and KOW motifs Gpkow 2.5996559 up 0.021185 1459836_x_at splicing factor 3b, subunit 2 Sf3b2 2.599424 up 0.003876 1460324_at DNA methyltransferase 3A Dnmt3a 2.5987701 up 0.000428 1448187_at polymerase (DNA directed), delta 1, catalytic subunit Pold1 2.59858 up 0.003499 1415856_at embigin Emb 2.59806 down 0.001690 1418524_at similar to pericentriolar material gene 1 protein LOC100044052 2.5978968 up 0.000317 1422474_at phosphodiesterase 4B, cAMP specific Pde4b 2.5970006 up 0.000119 1435329_at F-box and leucine-rich repeat protein 11 Fbxl11 2.5958567 up 0.029699 1429435_x_at phosphatidylinositol 3-kinase, catalytic, alpha polypeptide Pik3ca 2.595468 up 0.000598 1422270_a_at interleukin 6 receptor, alpha Il6ra 2.5946498 down 0.013888 1435035_at RNA (guanine-9-) methyltransferase domain containing 2 /// similar to RNA (guanine-9-) methyltransferaLOC100045440 /// Rg 2.5942993 up 0.000702 1455084_x_at serine hydroxymethyltransferase 2 (mitochondrial) Shmt2 2.5940666 up 0.020955 1455402_at suppressor of cytokine signaling 7 Socs7 2.5939448 up 0.000183 1453224_at zinc finger, AN1-type domain 5 Zfand5 2.5939252 down 0.000075 1429490_at Rap1 interacting factor 1 homolog (yeast) Rif1 2.5904477 up 0.001144 1454875_a_at retinoblastoma binding protein 4 Rbbp4 2.5904133 down 0.001206 1450662_at testis specific protein kinase 1 Tesk1 2.5903199 up 0.030435 1420723_at vanin 3 Vnn3 2.5902069 down 0.016463 1437474_at GATA zinc finger domain containing 2B Gatad2b 2.589986 up 0.000148 1418911_s_at acyl-CoA synthetase long-chain family member 4 Acsl4 2.589107 up 0.005743 1422397_a_at interleukin 15 receptor, alpha chain Il15ra 2.5874946 up 0.010718 1419655_at transducin-like enhancer of split 3, homolog of Drosophila E(spl) /// similar to mKIAA1547 protein LOC100048342 /// Tle 2.5868797 up 0.000316 1451246_s_at aurora kinase B Aurkb 2.5849853 down 0.001477 1444358_at F-box and leucine-rich repeat protein 11 Fbxl11 2.5846243 up 0.007545 1438712_at DENN/MADD domain containing 2D Dennd2d 2.5830479 up 0.004299 1454693_at Histone deacetylase 4 Hdac4 2.5829215 up 0.006525 1429783_at PDZ and LIM domain 5 Pdlim5 2.5804272 up 0.004186 1454201_a_at cyclin Y Ccny 2.5801578 down 0.001379 1453864_at retinol dehydrogenase 14 (all-trans and 9-cis) Rdh14 2.5786157 up 0.025440 1417196_s_at WW, C2 and coiled-coil domain containing 2 Wwc2 2.57696 up 0.000002 1434830_at MAX dimerization protein 1 Mxd1 2.5764654 up 0.005573 1436366_at protein phosphatase 1, regulatory (inhibitor) subunit 15b Ppp1r15b 2.575273 up 0.018965 1434313_at coiled-coil domain containing 126 Ccdc126 2.574475 up 0.010526 1460399_at coiled-coil domain containing 117 Ccdc117 2.5716813 up 0.007073 1451167_at coiled-coil domain containing 101 /// similar to coiled-coil domain containing 101 Ccdc101 /// LOC1000 2.5716696 down 0.000821 1420591_at G protein-coupled receptor 84 Gpr84 2.5714025 down 0.002099 1428173_at echinoderm microtubule associated protein like 2 Eml2 2.5713906 up 0.000295 1438842_at mitochondrial carrier homolog 2 (C. elegans) /// similar to Mtch2 protein LOC100039384 /// LO 2.5711489 up 0.017620 1436689_a_at aldehyde dehydrogenase 9, subfamily A1 Aldh9a1 2.5710626 up 0.000002 1421147_at telomeric repeat binding factor 2 Terf2 2.5675275 up 0.000261 1421571_a_at lymphocyte antigen 6 complex, locus C1 /// similar to Lymphocyte antigen 6C precursor (Ly-6C) /// lymp LOC100041546 /// LO 2.566556 down 0.000376 1420835_at solute carrier family 25, member 30 Slc25a30 2.5664618 down 0.004116 1423254_x_at ribosomal protein S27-like Rps27l 2.5652177 down 0.000159 1426609_at DIS3 mitotic control homolog (S. cerevisiae) Dis3 2.5637512 up 0.010211 1436405_at dedicator of cytokinesis 4 Dock4 2.5610683 up 0.008491 1419647_a_at immediate early response 3 Ier3 2.560123 up 0.001668 1428305_at proprotein convertase subtilisin/kexin type 2 Pcsk2 2.5594215 down 0.004168 1436758_at histone deacetylase 4 Hdac4 2.5582485 up 0.007674 1417128_at pleckstrin homology domain containing, family O member 1 Plekho1 2.5575173 down 0.000103 1452841_at phosphoglucomutase 2-like 1 Pgm2l1 2.5570886 up 0.024966 1418015_at pumilio 2 (Drosophila) Pum2 2.557037 up 0.013773 1441973_at zinc finger protein 295 Zfp295 2.5569086 up 0.027356 1434782_at ubiquitin specific peptidase 42 Usp42 2.5567296 up 0.000182 1451731_at ATP-binding cassette, sub-family A (ABC1), member 3 Abca3 2.5556092 up 0.000026 1428577_at protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 Ppfia4 2.5527844 down 0.000389 1417799_at ATPase, H+ transporting, lysosomal V1 subunit G2 Atp6v1g2 2.5525043 up 0.006139 1427418_a_at hypoxia inducible factor 1, alpha subunit Hif1a 2.552265 up 0.000030 1424317_at solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 Slc25a19 2.5501623 up 0.012237 1428433_at homeodomain interacting protein kinase 2 Hipk2 2.5495179 up 0.000020 1442048_at ring finger protein 11 Rnf11 2.5489788 up 0.000567 1458450_at zinc finger RNA binding protein Zfr 2.5474324 up 0.002097 1428848_a_at microtubule-actin crosslinking factor 1 Macf1 2.545478 down 0.001550 1424669_at zinc finger, FYVE domain containing 21 Zfyve21 2.5450935 down 0.005488 1417385_at aminopeptidase puromycin sensitive Npepps 2.5450466 up 0.028341 1437647_at death inducer-obliterator 1 Dido1 2.5445604 up 0.004300 1430578_at eukaryotic translation initiation factor 4 gamma, 3 Eif4g3 2.5427713 up 0.004037 1436858_at muscleblind-like 2 Mbnl2 2.5424435 down 0.003145 1420631_a_at bladder cancer associated protein homolog (human) Blcap 2.5423822 up 0.000006 1418698_a_at ferrochelatase Fech 2.5419888 down 0.021604 1424778_at receptor accessory protein 3 Reep3 2.5416772 down 0.033242 1435091_at zinc finger protein 568 Zfp568 2.5413556 up 0.000352 1457824_at Phospholipid scramblase 1 Plscr1 2.5406182 up 0.016170 1423140_at lysosomal acid lipase A Lipa 2.5403242 up 0.000530 1455551_at UEV and lactate/malate dehyrogenase domains Uevld 2.5400765 up 0.000077 1429304_at ankyrin repeat domain 10 Ankrd10 2.5388653 up 0.002050 1449551_at myosin IC Myo1c 2.5383587 down 0.000240 1419453_at ubiquitin carboxyl-terminal esterase L5 Uchl5 2.5383434 up 0.001635 1458602_at bobby sox homolog (Drosophila) Bbx 2.5381498 up 0.006378 1440298_at triggering receptor expressed on myeloid cells-like 2 /// similar to trem-like transcript 2 LOC100047904 /// Tr 2.5359662 up 0.018652 1452292_at adaptor-related protein complex 2, beta 1 subunit Ap2b1 2.534467 up 0.002739 1429434_at phosphatidylinositol 3-kinase, catalytic, alpha polypeptide Pik3ca 2.533549 up 0.000178 1442059_at fragile X mental retardation gene 1, autosomal homolog Fxr1h 2.5325446 up 0.001615 1425581_s_at UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7 Galnt7 2.5311344 down 0.030733 1448222_x_at cytochrome c oxidase, subunit VIIIa Cox8a 2.530866 down 0.000113 1439882_at Sec23 interacting protein Sec23ip 2.5305774 up 0.001763 1452228_at TBC1 domain family, member 23 Tbc1d23 2.5303464 down 0.001427 1429881_at Rho GTPase activating protein 15 Arhgap15 2.5286486 down 0.000652 1438844_x_at spermatogenesis associated 5 Spata5 2.5280592 up 0.006520 1420643_at LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Lfng 2.5255046 up 0.000032 1460025_at leucine-rich repeats and immunoglobulin-like domains 2 Lrig2 2.5247252 up 0.015354 1423467_at membrane-spanning 4-domains, subfamily A, member 4B Ms4a4b 2.5245767 down 0.000927 1441058_at inositol 1,4,5-trisphosphate 3-kinase B Itpkb 2.5211227 up 0.006762 1441727_s_at zinc finger protein 467 Zfp467 2.5206628 up 0.000233 1436913_at CDC14 cell division cycle 14 homolog A (S. cerevisiae) Cdc14a 2.5201898 up 0.000878 1455169_at RAB11 family interacting protein 2 (class I) Rab11fip2 2.5197508 up 0.025123 1450576_a_at splicing factor 3a, subunit 2 Sf3a2 2.519473 up 0.000052 1441452_at LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae) Lsm1 2.5186195 up 0.030339 1439153_at IBR domain containing 2 Ibrdc2 2.5166054 up 0.003494 1424580_at solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3 Slc35a3 2.5163069 up 0.002980 1434592_at solute carrier family 16 (monocarboxylic acid transporters), member 10 Slc16a10 2.5117707 up 0.001753 1420697_at solute carrier family 15, member 3 Slc15a3 2.5117161 up 0.001787 1437325_x_at aldehyde dehydrogenase 18 family, member A1 Aldh18a1 2.5115085 up 0.000159 1435772_at kinesin family member 21B Kif21b 2.5115018 up 0.000331 1452481_at phospholipase C, beta 2 Plcb2 2.5114338 down 0.021501 1426483_at protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressPrkrir 2.5113258 up 0.001703 1455204_at phosphatidylinositol transfer protein, cytoplasmic 1 Pitpnc1 2.5110943 down 0.016994 1455012_s_at tripartite motif protein 37 Trim37 2.5081456 up 0.000396 1431760_a_at serologically defined colon cancer antigen 3 Sdccag3 2.5075595 down 0.018736 1435001_at phospholipase A2, activating protein Plaa 2.5045826 up 0.004438 1439024_at BCL2-associated athanogene 4 Bag4 2.5043764 up 0.006782 1423166_at CD36 antigen Cd36 2.5023808 up 0.000283 1455964_at Cdc2-related kinase, arginine/serine-rich Crkrs 2.500805 up 0.000717 1415857_at embigin Emb 2.4990482 down 0.000908 1434320_at general transcription factor IIIC, polypeptide 4 Gtf3c4 2.4971285 up 0.006551 1433757_a_at nischarin Nisch 2.4968767 up 0.000457 1435203_at mannosidase 2, alpha 2 Man2a2 2.4964955 up 0.000294 1428487_s_at coenzyme Q10 homolog B (S. cerevisiae) Coq10b 2.4943066 up 0.000033 1446928_at DnaJ (Hsp40) homolog, subfamily C, member 17 /// similar to DnaJ (Hsp40) homolog, subfamily C, memDnajc17 /// LOC6217 2.493573 down 0.000258 1454704_at scavenger receptor class B, member 2 Scarb2 2.4921212 up 0.000037 1448700_at G0/G1 switch gene 2 G0s2 2.4907641 up 0.002142 1435664_at zinc finger protein 397 Zfp397 2.4881492 up 0.005417 1430533_a_at catenin (cadherin associated protein), beta 1 Ctnnb1 2.4869013 down 0.000218 1456466_x_at ataxin 10 Atxn10 2.4868503 up 0.000682 1423255_at ATPase, H+ transporting, lysosomal V1 subunit G1 Atp6v1g1 2.4868436 down 0.000016 1455901_at choline phosphotransferase 1 Chpt1 2.485974 up 0.007719 1433774_x_at component of oligomeric golgi complex 1 Cog1 2.4851692 down 0.000059 1451722_s_at SET and MYND domain containing 5 Smyd5 2.4840457 up 0.003475 1451536_at mitochondrial fission regulator 1 Mtfr1 2.4838274 up 0.001078 1455564_at Breakpoint cluster region homolog Bcr 2.4836392 up 0.000626 1420768_a_at DEXH (Asp-Glu-X-His) box polypeptide 58 Dhx58 2.4829335 down 0.010832 1437199_at dual specificity phosphatase 5 Dusp5 2.48288 up 0.000123 1435840_x_at similar to 2-cell-stage, variable group, member 3 LOC625360 2.4821901 down 0.000200 1448104_at aldehyde dehydrogenase family 6, subfamily A1 Aldh6a1 2.4819415 up 0.001348 1454748_at nicotinate phosphoribosyltransferase domain containing 1 Naprt1 2.4782958 up 0.011158 1455653_at cyclin J Ccnj 2.477477 up 0.002628 1428311_at coiled-coil domain containing 6 Ccdc6 2.4770858 up 0.005643 1457604_x_at cytochrome P450, family 11, subfamily a, polypeptide 1 Cyp11a1 2.4752007 down 0.031453 1435574_at Cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1 Chordc1 2.4750538 up 0.003482 1428793_at solute carrier family 36 (proton/amino acid symporter), member 1 Slc36a1 2.4748607 up 0.000136 1441880_x_at transmembrane protein 149 /// U2 small nuclear RNA auxiliary factor 1-like 4 Tmem149 /// U2af1l4 2.474635 up 0.000064 1418770_at CD2 antigen Cd2 2.4741106 down 0.007927 1435495_at adenosine A1 receptor Adora1 2.4706843 down 0.004992 1451721_a_at histocompatibility 2, class II antigen A, beta 1 H2-Ab1 2.4703398 down 0.002884 1453230_at zinc finger protein 74 Zfp74 2.4678073 up 0.009707 1433795_at transforming growth factor, beta receptor III Tgfbr3 2.4675734 up 0.000014 1451776_s_at homeobox only domain Hod 2.4658165 down 0.000343 1446844_at coiled-coil-helix-coiled-coil-helix domain containing 7 Chchd7 2.4650805 up 0.002540 1426086_a_at fragile X mental retardation syndrome 1 homolog Fmr1 2.4607515 down 0.002760 1434808_at partner and localizer of BRCA2 Palb2 2.4587328 up 0.008137 1424211_at solute carrier family 25, member 33 Slc25a33 2.4587018 up 0.008340 1439068_at type 1 tumor necrosis factor receptor shedding aminopeptidase regulator Arts1 2.458472 up 0.000254 1455940_x_at WD repeat domain 6 Wdr6 2.4572632 up 0.003915 1428095_a_at transmembrane protein 24 Tmem24 2.4571073 up 0.000523 1456827_at expressed sequence AA987161 AA987161 2.456286 down 0.001378 1435158_at RNA binding motif protein 12B Rbm12b 2.456063 up 0.003514 1435675_at TBC1D12: TBC1 domain family, member 12 Tbc1d12 2.4560437 up 0.001193 1428058_at AHNAK nucleoprotein (desmoyokin) Ahnak 2.4555387 down 0.012734 1436313_at SCY1-like 2 (S. cerevisiae) Scyl2 2.4550583 up 0.004032 1454971_x_at TSC22 domain family, member 1 Tsc22d1 2.4535608 up 0.029336 1442788_at actin filament associated protein 1 Afap1 2.4534879 down 0.000411 1429650_at serine/threonine kinase 40 Stk40 2.452827 up 0.000830 1435727_s_at LIM domain and actin binding 1 Lima1 2.4512718 up 0.004662 1419499_at glycerol-3-phosphate acyltransferase, mitochondrial Gpam 2.4510775 up 0.000790 1459974_x_at TBC1 domain family, member 9B Tbc1d9b 2.4489496 up 0.000262 1437499_at ankyrin repeat domain 39 Ankrd39 2.4480138 up 0.028756 1428294_at zinc finger protein 259 Zfp259 2.4464777 up 0.004110 1430391_a_at ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 St8sia4 2.4461486 down 0.019748 1420865_at zinc finger protein 161 Zfp161 2.4444563 up 0.001429 1455682_at v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene) Abl2 2.444066 up 0.022770 1433983_at Cnksr family member 3 Cnksr3 2.4412217 up 0.000499 1455863_at spermatogenesis associated 5-like 1 Spata5l1 2.441108 up 0.000508 1420089_at Nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha Nfkbia 2.44042 up 0.000061 1416750_at opioid receptor, sigma 1 Oprs1 2.439978 down 0.000273 1448235_s_at high mobility group box 1 /// RIKEN cDNA 4932431P20 gene /// predicted gene, EG432959 /// high-mob 4932431P20Rik /// EG 2.4392104 down 0.000062 1433811_at myeloid/lymphoid or mixed lineage-leukemia translocation to 6 homolog (Drosophila) Mllt6 2.4381769 up 0.000324 1438654_x_at monocyte to macrophage differentiation-associated 2 Mmd2 2.4381394 down 0.006656 1436959_x_at nasal embryonic LHRH factor Nelf 2.4368832 up 0.008879 1439938_at serine/threonine kinase 38 Stk38 2.435565 down 0.002786 1434078_at ubiquitin family domain containing 1 Ubfd1 2.4326775 up 0.005503 1437359_at ribonucleic acid binding protein S1 Rnps1 2.4317193 up 0.002761 1437553_at BRCA1/BRCA2-containing complex, subunit 3 Brcc3 2.4300442 up 0.006129 1424008_a_at RNA binding protein with multiple splicing 2 Rbpms2 2.4297197 up 0.029212 1426622_a_at glutaminyl-peptide cyclotransferase (glutaminyl cyclase) Qpct 2.4288437 down 0.005007 1449001_at isovaleryl coenzyme A dehydrogenase Ivd 2.4287803 up 0.006035 1448921_a_at mitochondrial ribosomal protein S9 Mrps9 2.4285932 up 0.001511 1433467_at solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 Slc7a6 2.4280899 up 0.000710 1460441_at zinc finger, X-linked, duplicated B Zxdb 2.4279962 up 0.001279 1454901_at yippee-like 2 (Drosophila) Ypel2 2.4278235 up 0.009274 1457240_at cyclin-dependent kinase 9 (CDC2-related kinase) Cdk9 2.4244516 up 0.000048 1439108_at myeloid/lymphoid or mixed-lineage leukemia 5 Mll5 2.4231892 down 0.000666 1426598_at ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome Uty 2.4225805 up 0.021942 1436769_at proteasome (prosome, macropain) subunit, alpha type 1 Psma1 2.4214702 up 0.005945 1423742_at RNA binding motif protein 10 Rbm10 2.420963 down 0.032893 1460287_at tissue inhibitor of metalloproteinase 2 Timp2 2.4157128 down 0.011646 1436012_s_at secernin 2 Scrn2 2.4155276 down 0.009035 1434916_at vitamin K epoxide reductase complex, subunit 1-like 1 Vkorc1l1 2.414664 up 0.000610 1449858_at CD86 antigen Cd86 2.414372 down 0.004115 1428170_at zinc finger protein 180 Zfp180 2.4143553 up 0.001387 1424779_at receptor accessory protein 3 Reep3 2.4140224 down 0.009973 1435272_at inositol 1,4,5-trisphosphate 3-kinase B Itpkb 2.4138827 up 0.017959 1437877_at tetratricopeptide repeat domain 14 Ttc14 2.4138365 down 0.001476 1450681_at zinc finger protein 143 Zfp143 2.413819 up 0.007358 1443087_at CDC23 (cell division cycle 23, yeast, homolog) Cdc23 2.4121513 up 0.001843 1416147_at heat shock protein 4 Hspa4 2.4112172 up 0.000296 1436192_at ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) Arfgef2 2.4111154 up 0.004389 1424665_at G patch domain containing 8 Gpatch8 2.408462 up 0.012972 1454740_at mindbomb homolog 1 (Drosophila) Mib1 2.407577 up 0.000012 1416957_at POU domain, class 2, associating factor 1 Pou2af1 2.405222 up 0.032459 1422479_at acyl-CoA synthetase short-chain family member 2 Acss2 2.4043183 up 0.000014 1438580_at zinc finger, CCHC domain containing 7 Zcchc7 2.402161 down 0.002159 1426775_s_at secretory carrier membrane protein 1 Scamp1 2.399176 up 0.011388 1429903_at D4, zinc and double PHD fingers family 2 Dpf2 2.398242 up 0.027003 1438164_x_at flotillin 2 Flot2 2.3982387 up 0.009224 1434540_a_at clathrin, light polypeptide (Lca) Clta 2.3959823 down 0.000007 1447883_x_at microtubule-associated protein 1 light chain 3 alpha Map1lc3a 2.3949213 up 0.000063 1419067_a_at RAB guanine nucleotide exchange factor (GEF) 1 Rabgef1 2.3945897 up 0.001964 1444595_at zinc finger, X-linked, duplicated A /// similar to zinc finger, X-linked, duplicated A LOC100044735 /// Zx 2.3935041 up 0.000953 1421073_a_at prostaglandin E receptor 4 (subtype EP4) Ptger4 2.3934352 down 0.002999 1440517_x_at cytidine monophospho-N-acetylneuraminic acid hydroxylase Cmah 2.393138 down 0.000746 1435253_at RAB11B, member RAS oncogene family Rab11b 2.3929465 up 0.010642 1452247_at fragile X mental retardation gene 1, autosomal homolog Fxr1h 2.3922 up 0.003611 1429253_at zinc finger, MYM-type 4 Zmym4 2.3917692 up 0.005832 1456498_at integrin alpha 4 Itga4 2.3917255 down 0.000854 1426756_at UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 Galnt2 2.3901846 down 0.000049 1454783_at interleukin 13 receptor, alpha 1 Il13ra1 2.390074 down 0.000119 1423333_at endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 Ergic1 2.3873734 up 0.001563 1425626_at glutathione S-transferase, mu 1 /// similar to Glutathione S-transferase Mu 1 (GST class-mu 1) (Glutathi Gstm1 /// LOC100043 2.3867955 up 0.001616 1438761_a_at ornithine decarboxylase, structural 1 /// similar to Ornithine decarboxylase (ODC) /// similar to Odc1 prot EG666231 /// EG6683 2.3865092 up 0.026391 1440964_s_at expressed sequence AI465270 AI465270 2.386162 up 0.000162 1435540_at immunity-related GTPase family, Q Irgq 2.3858602 up 0.000027 1426313_at brain and reproductive organ-expressed protein Bre 2.385137 down 0.000056 1439226_at dedicator of cytokinesis 8 Dock8 2.3842432 down 0.003595 1416714_at interferon regulatory factor 8 Irf8 2.3832316 down 0.000001 1422806_x_at inhibitor of growth family, member 3 Ing3 2.3831089 up 0.000018 1434043_a_at replication initiator 1 Repin1 2.3830867 up 0.002162 1455865_at insulinoma-associated 1 Insm1 2.382746 down 0.001652 1447670_at proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 Psmd9 2.382649 up 0.001056 1428543_at phosphoribosyl pyrophosphate amidotransferase Ppat 2.3823354 up 0.030368 1428763_at single-strand selective monofunctional uracil DNA glycosylase Smug1 2.3810272 up 0.002353 1451092_a_at RAN GTPase activating protein 1 Rangap1 2.3807108 up 0.004106 1441788_s_at dyskeratosis congenita 1, dyskerin homolog (human) Dkc1 2.3788135 up 0.000080 1421326_at colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) Csf2rb 2.3786516 down 0.002504 1450172_at Pbx/knotted 1 homeobox Pknox1 2.378537 down 0.002673 1455600_at ribosomal protein S3 Rps3 2.3780353 up 0.001639 1427783_at v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) Erbb4 2.3776262 down 0.008498 1415690_at mitochondrial ribosomal protein L27 Mrpl27 2.376987 down 0.000028 1421525_a_at NLR family, apoptosis inhibitory protein 5 Naip5 2.3765283 up 0.000054 1435781_at cullin associated and neddylation disassociated 1 Cand1 2.3739228 up 0.002115 1420472_at myotrophin Mtpn 2.373751 down 0.001052 1422492_at coproporphyrinogen oxidase Cpox 2.373393 up 0.000175 1417541_at helicase, lymphoid specific Hells 2.3730073 up 0.003077 1429362_a_at splicing factor 3b, subunit 2 Sf3b2 2.37296 down 0.000183 1419829_a_at Growth factor receptor bound protein 2-associated protein 2 Gab2 2.3699598 up 0.000394 1455308_at transmembrane protein 16F Tmem16f 2.369756 up 0.000996 1422903_at lymphocyte antigen 86 Ly86 2.369543 down 0.000128 1424395_at asparaginase like 1 Asrgl1 2.3695407 up 0.013860 1433614_at sorting nexin family member 27 Snx27 2.36933 up 0.003121 1451677_at nuclear prelamin A recognition factor Narf 2.3690267 up 0.000904 1436884_x_at Ewing sarcoma breakpoint region 1 Ewsr1 2.3688257 up 0.000064 1429063_s_at kinesin family member 16B Kif16b 2.3664453 up 0.004133 1418798_s_at serine/arginine-rich protein specific kinase 3 Srpk3 2.365461 up 0.003015 1416576_at suppressor of cytokine signaling 3 Socs3 2.3640063 down 0.001380 1416755_at DnaJ (Hsp40) homolog, subfamily B, member 1 Dnajb1 2.3638422 up 0.000329 1435225_s_at bromodomain and PHD finger containing, 3 Brpf3 2.3624353 up 0.000929 1450985_a_at tight junction protein 2 Tjp2 2.3616977 up 0.009496 1451989_a_at microtubule-associated protein, RP/EB family, member 2 Mapre2 2.360435 up 0.000690 1452849_at transcriptional regulator, SIN3B (yeast) Sin3b 2.3602846 up 0.000531 1457708_at methyl-CpG binding domain protein 4 Mbd4 2.3602693 up 0.000154 1419701_s_at ankyrin repeat and sterile alpha motif domain containing 3 Anks3 2.3567154 up 0.000174 1419181_at zinc finger protein 326 Zfp326 2.356609 up 0.006183 1454677_at tissue inhibitor of metalloproteinase 2 Timp2 2.3558366 down 0.030616 1460565_at solute carrier family 41, member 1 Slc41a1 2.3547888 up 0.000819 1437314_a_at TRM1 tRNA methyltransferase 1 homolog (S. cerevisiae) Trmt1 2.354419 down 0.001061 1420384_at procollagen, type IV, alpha 3 (Goodpasture antigen) binding protein Col4a3bp 2.3523865 up 0.001840 1420918_at serum/glucocorticoid regulated kinase 3 Sgk3 2.3521938 down 0.000088 1453166_at coiled-coil domain containing 109A Ccdc109a 2.3509805 up 0.009277 1453198_at zinc finger protein 422, related sequence 1 /// similar to Zinc finger protein 422, related sequence 1 LOC100043468 /// Zfp 2.3506145 up 0.001431 1418495_at zinc finger CCCH type containing 8 Zc3h8 2.3485868 up 0.000153 1438804_at septin 10 Sept10 2.346983 down 0.006360 1426267_at zinc finger and BTB domain containing 8 opposite strand Zbtb8os 2.3460298 up 0.000388 1420519_a_at Era (G-protein)-like 1 (E. coli) Eral1 2.345642 down 0.008500 1427329_a_at immunoglobulin heavy chain 6 (heavy chain of IgM) Igh-6 2.3456335 down 0.000647 1459855_x_at ARP1 actin-related protein 1 homolog A (yeast) Actr1a 2.3444731 up 0.000338 1443894_at Ecotropic viral integration site 2a Evi2a 2.3426025 down 0.000103 1454671_at insulin induced gene 1 Insig1 2.3423502 up 0.002152 1456112_at translocated promoter region /// similar to nuclear pore complex-associated intranuclear coiled-coil proteLOC100043998 /// Tp 2.3404582 down 0.017870 1438555_x_at mucin 4 Muc4 2.3403153 down 0.000595 1455210_at zinc fingers and homeoboxes protein 2 Zhx2 2.3401859 up 0.002903 1427152_at glutamine and serine rich 1 Qser1 2.3399198 up 0.002207 1421138_a_at protein kinase inhibitor beta, cAMP dependent, testis specific Pkib 2.33898 down 0.005982 1456803_at Polymerase (RNA) III (DNA directed) polypeptide C Polr3c 2.338855 up 0.000936 1415988_at high density lipoprotein (HDL) binding protein Hdlbp 2.338651 down 0.017859 1427384_at chromodomain helicase DNA binding protein 6 Chd6 2.3383262 up 0.000566 1442466_a_at histidine acid phosphatase domain containing 2A Hisppd2a 2.3376725 up 0.002863 1422024_at Friend leukemia integration 1 Fli1 2.3362684 down 0.002927 1449671_at G protein-coupled receptor 137B Gpr137b 2.336253 up 0.000078 1450400_at trimethylguanosine synthase homolog (S. cerevisiae) Tgs1 2.3361502 down 0.001473 1452885_at splicing factor, arginine/serine-rich 2, interacting protein Sfrs2ip 2.3356469 down 0.013962 1449577_x_at tropomyosin 2, beta Tpm2 2.3341832 down 0.000823 1425546_a_at transferrin Trf 2.3340857 up 0.002585 1424394_at selenoprotein M Selm 2.3336914 down 0.000561 1450494_x_at CEA-related cell adhesion molecule 1 Ceacam1 2.3335612 down 0.000055 1426562_a_at olfactomedin 1 Olfm1 2.3320665 down 0.000617 1418250_at ADP-ribosylation factor-like 4D /// hypothetical protein LOC100038842 /// hypothetical protein LOC10004Arl4d /// LOC1000388 2.3314772 up 0.023386 1452783_at fibronectin type III domain containing 3B Fndc3b 2.3312192 down 0.007945 1460600_at similar to Ubiquitin-conjugating enzyme E2Q (putative) 2 /// similar to CG2924-PC, isoform C LOC245350 /// LOC6 2.3305056 down 0.003011 1437402_x_at transmembrane protein 41B Tmem41b 2.3294923 up 0.001435 1418704_at S100 calcium binding protein A13 S100a13 2.328901 down 0.000052 1424698_s_at grancalcin Gca 2.3279753 up 0.002919 1422348_at similar to H-2 class I histocompatibility antigen, L-D alpha chain precursor LOC676708 2.3234959 down 0.001631 1424986_s_at F-box and WD-40 domain protein 7, archipelago homolog (Drosophila) Fbxw7 2.3234308 up 0.001472 1455852_at NSL1, MIND kinetochore complex component, homolog (S. cerevisiae) Nsl1 2.3232372 up 0.005579 1459961_a_at Signal transducer and activator of transcription 3 Stat3 2.3228803 up 0.002586 1437453_s_at proprotein convertase subtilisin/kexin type 9 Pcsk9 2.322769 down 0.014174 1434314_s_at RAB11 family interacting protein 5 (class I) Rab11fip5 2.3207898 up 0.001600 1455900_x_at transglutaminase 2, C polypeptide Tgm2 2.3194003 up 0.000089 1453604_a_at Hbs1-like (S. cerevisiae) Hbs1l 2.3178966 down 0.003606 1447150_at pam, highwire, rpm 1 Phr1 2.3176384 down 0.015550 1439766_x_at vascular endothelial growth factor C Vegfc 2.3165946 up 0.002201 1426870_at F-box protein 33 Fbxo33 2.3162622 up 0.001547 1443972_at expressed sequence AI465300 AI465300 2.3159723 down 0.019179 1416141_a_at ribosomal protein S6 /// predicted gene, EG666577 /// similar to ribosomal protein S6 EG666577 /// LOC667 2.3150103 down 0.000945 1438685_at zinc finger, MYM-type 6 Zmym6 2.3148289 up 0.004223 1447495_at fibronectin type 3 and ankyrin repeat domains 1 Fank1 2.3142636 down 0.007060 1425042_s_at proline, glutamic acid and leucine rich protein 1 Pelp1 2.313137 up 0.004881 1420845_at mitochondrial ribosomal protein S2 Mrps2 2.3111694 down 0.014478 1430777_a_at golgi phosphoprotein 3 Golph3 2.310556 down 0.002440 1450414_at platelet derived growth factor, B polypeptide Pdgfb 2.3104644 down 0.000608 1426278_at interferon, alpha-inducible protein 27 Ifi27 2.3097062 down 0.001275 1456573_x_at nicotinamide nucleotide transhydrogenase Nnt 2.3091154 up 0.001296 1422123_s_at CEA-related cell adhesion molecule 1 /// CEA-related cell adhesion molecule 2 Ceacam1 /// Ceacam 2.3081005 down 0.001541 1438317_a_at endonuclease G Endog 2.3079967 up 0.003668 1443733_x_at polymerase (DNA-directed), delta 3, accessory subunit Pold3 2.3077374 up 0.000031 1430230_at RCSD domain containing 1 Rcsd1 2.3074594 down 0.002810 1419254_at methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase Mthfd2 2.306897 down 0.000040 1450935_at excision repair cross-complementing rodent repair deficiency, complementation group 5 Ercc5 2.3057337 up 0.001424 1455665_at LON peptidase N-terminal domain and ring finger 1 /// similar to CG32369-PB, isoform B LOC631639 /// Lonrf1 2.3044004 up 0.000210 1434951_at armadillo repeat containing 8 Armc8 2.304262 up 0.008815 1452074_at transmembrane protein 135 Tmem135 2.3034022 up 0.013207 1449079_s_at ST3 beta-galactoside alpha-2,3-sialyltransferase 6 St3gal6 2.303186 down 0.031745 1460359_at armadillo repeat containing, X-linked 3 /// hypothetical protein LOC100044266 Armcx3 /// LOC10004 2.3010638 up 0.000669 1418075_at ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransfeSt6galnac4 2.3009849 up 0.000020 1449362_a_at misshapen-like kinase 1 (zebrafish) /// hypothetical protein LOC100048805 LOC100048805 /// Mi 2.2994497 up 0.000008 1416382_at cathepsin C Ctsc 2.2987332 down 0.000039 1417879_at neuron derived neurotrophic factor Nenf 2.2985137 down 0.000017 1438292_x_at adenosine kinase Adk 2.298449 up 0.000636 1427021_s_at ferritin heavy chain 1 Fth1 2.297861 down 0.000290 1456818_at serine/threonine kinase 32A Stk32a 2.2977977 down 0.002214 1426943_at integrator complex subunit 1 Ints1 2.296574 up 0.012416 1427940_s_at c-myc binding protein Mycbp 2.2951446 up 0.000000 1422776_at serine (or cysteine) peptdiase inhibitor, clade B, member 8 Serpinb8 2.2948744 down 0.021455 1456494_a_at tripartite motif protein 30 /// expressed sequence AI451617 AI451617 /// Trim30 2.2943625 down 0.001573 1421285_at phosphoinositide-3-kinase adaptor protein 1 Pik3ap1 2.2941594 down 0.000057 1448639_a_at spermatogenesis associated 5 Spata5 2.2938197 up 0.000647 1439601_at HEAT repeat containing 6 Heatr6 2.2935529 up 0.012248 1417328_at excision repair cross-complementing rodent repair deficiency, complementation group 1 Ercc1 2.2933042 down 0.001547 1426127_x_at killer cell lectin-like receptor, subfamily A, member 18 Klra18 2.2930322 up 0.004018 1434988_x_at aldehyde dehydrogenase 2, mitochondrial Aldh2 2.2922084 up 0.002222 1435152_at leukocyte receptor cluster (LRC) member 8 Leng8 2.29103 up 0.000052 1424177_at transmembrane protein 38A Tmem38a 2.2897873 down 0.000001 1457304_at DNA segment, Chr 13, ERATO Doi 787, expressed D13Ertd787e 2.2897124 down 0.009797 1448348_at cell cycle associated protein 1 Caprin1 2.2895598 down 0.017729 1452585_at mitochondrial ribosomal protein S28 Mrps28 2.2885847 down 0.004870 1454169_a_at epithelial stromal interaction 1 (breast) Epsti1 2.2878246 down 0.000014 1439082_at DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 Ddx50 2.287708 up 0.010033 1427871_at platelet-activating factor receptor Ptafr 2.2872458 down 0.000121 1426667_a_at unc-84 homolog A (C. elegans) Unc84a 2.286766 down 0.000060 1456548_at Metadherin Mtdh 2.2863727 down 0.019133 1434128_a_at zinc finger protein 574 Zfp574 2.2862794 up 0.000325 1422953_at formyl peptide receptor, related sequence 2 Fpr-rs2 2.2853003 up 0.002853 1437508_at trans-acting transcription factor 4 Sp4 2.2839947 up 0.001105 1438056_x_at ATP-binding cassette, sub-family C (CFTR/MRP), member 5 Abcc5 2.2839139 up 0.008088 1429739_a_at POZ (BTB) and AT hook containing zinc finger 1 Patz1 2.2839026 up 0.000612 1455547_at zinc finger CCCH type containing 7B Zc3h7b 2.2835932 up 0.001258 1454665_at interferon regulatory factor 2 binding protein 2 Irf2bp2 2.2786427 up 0.016471 1457213_a_at diacylglycerol kinase, eta Dgkh 2.2782104 down 0.006812 1457472_at trinucleotide repeat containing 15 Tnrc15 2.2781088 up 0.002460 1451044_at survivor of motor neuron protein interacting protein 1 Sip1 2.2778113 up 0.009438 1456437_x_at complement component 1, r subcomponent /// similar to complement component C1rb C1r /// LOC667277 2.2775464 down 0.000123 1451873_a_at MAD homolog 5 (Drosophila) Smad5 2.2772634 up 0.022658 1423909_at transmembrane protein 176A Tmem176a 2.2769856 down 0.030364 1459756_at CCR4-NOT transcription complex, subunit 10 Cnot10 2.2764819 up 0.004340 1436695_x_at RNA binding motif and ELMO domain 1 /// similar to RNA binding motif and ELMO domain 1 LOC100047355 /// Rb 2.2745733 down 0.029236 1422472_at peroxisomal biogenesis factor 13 Pex13 2.274503 up 0.033038 1423219_a_at mitochondrial ribosomal protein L49 Mrpl49 2.273661 down 0.009946 1435364_at cysteine and histidine rich 1 Cyhr1 2.2736294 up 0.016124 1417922_at kelch repeat and BTB (POZ) domain containing 4 Kbtbd4 2.2730703 up 0.001962 1431305_at mucolipin 1 Mcoln1 2.2718835 up 0.028503 1456424_s_at phospholipid transfer protein Pltp 2.271722 up 0.003047 1435855_x_at aldehyde dehydrogenase 18 family, member A1 Aldh18a1 2.271539 up 0.003153 1436902_x_at thymosin, beta 10 /// similar to thymosin, beta 10 LOC100043712 /// LO 2.2713964 down 0.000424 1426794_at protein tyrosine phosphatase, receptor type, S Ptprs 2.2711575 up 0.000139 1423982_at FUS interacting protein (serine-arginine rich) 1 Fusip1 2.2699687 up 0.003212 1416267_at short coiled-coil protein Scoc 2.2696643 up 0.000911 1424980_s_at anterior pharynx defective 1a homolog (C. elegans) /// similar to Aph1a protein Aph1a /// LOC100039 2.2691722 up 0.000618 1443762_s_at SET binding factor 2 Sbf2 2.267986 up 0.000548 1452860_at F-box and leucine-rich repeat protein 17 Fbxl17 2.2671885 up 0.000127 1452631_at RUN and FYVE domain-containing 2 Rufy2 2.2669866 down 0.000723 1419913_at Serine/threonine kinase receptor associated protein Strap 2.2667727 up 0.016065 1421173_at interferon regulatory factor 4 Irf4 2.266094 down 0.000744 1433632_at interferon regulatory factor 2 binding protein 2 Irf2bp2 2.2651544 up 0.010155 1439269_x_at minichromosome maintenance deficient 7 (S. cerevisiae) Mcm7 2.265117 up 0.002376 1455817_x_at zinc finger, X-linked, duplicated B Zxdb 2.2641258 up 0.003198 1417902_at solute carrier family 19 (thiamine transporter), member 2 Slc19a2 2.263106 up 0.003897 1443880_at zinc finger and BTB domain containing 39 Zbtb39 2.2627084 up 0.000087 1429083_at amylo-1,6-glucosidase, 4-alpha-glucanotransferase Agl 2.2625406 up 0.001396 1431253_s_at TBC1 domain family, member 9 Tbc1d9 2.2620513 down 0.008675 1455439_a_at lectin, galactose binding, soluble 1 Lgals1 2.2602527 down 0.000336 1449288_at growth differentiation factor 3 Gdf3 2.2600086 down 0.013488 1427896_at suppressor of defective silencing 3 homolog (S. cerevisiae) Suds3 2.2584755 up 0.001225 1415888_at hepatoma-derived growth factor Hdgf 2.2577918 up 0.004075 1436802_at interleukin enhancer binding factor 3 Ilf3 2.2567728 up 0.002617 1426092_a_at tripartite motif protein 34 Trim34 2.2567332 down 0.005375 1450710_at jumonji, AT rich interactive domain 2 Jarid2 2.2566905 down 0.000033 1434514_at RNA binding motif protein 15 Rbm15 2.256088 up 0.000462 1447671_x_at F-box protein 6 Fbxo6 2.256047 down 0.013924 1424841_s_at ribokinase Rbks 2.25547 down 0.001450 1460546_at leucine-rich repeat LGI family, member 3 Lgi3 2.2545986 down 0.021501 1427890_a_at leucine rich repeat containing 56 Lrrc56 2.2536423 up 0.000577 1436209_at DnaJ (Hsp40) homolog, subfamily C, member 16 Dnajc16 2.2535288 up 0.016841 1450570_a_at CD19 antigen Cd19 2.2531278 up 0.031542 1440222_at Superoxide dismutase 1, soluble Sod1 2.2526844 up 0.021769 1447901_x_at Sfi1 homolog, spindle assembly associated (yeast) Sfi1 2.2526398 up 0.006105 1425937_a_at hexamethylene bis-acetamide inducible 1 Hexim1 2.2523284 up 0.000327 1442763_s_at tubulin tyrosine ligase-like family, member 10 Ttll10 2.2522883 down 0.000646 1460460_a_at golgi reassembly stacking protein 2 Gorasp2 2.252181 down 0.000639 1460329_at similar to Beta-1,4-galactosyltransferase 6 (Beta-1,4-GalTase 6) (Beta4Gal-T6) (b4Gal-T6) (UDP-galact LOC675709 2.252007 up 0.031791 1433805_at Janus kinase 1 Jak1 2.2518864 down 0.000295 1426614_at protein kinase C binding protein 1 Prkcbp1 2.2515097 up 0.000743 1419366_at zinc finger, matrin type 5 Zmat5 2.2508364 down 0.001871 1423117_at pumilio 1 (Drosophila) Pum1 2.2499156 down 0.004244 1419620_at pituitary tumor-transforming 1 Pttg1 2.2494152 up 0.009254 1426241_a_at sex comb on midleg homolog 1 Scmh1 2.24774 up 0.000177 1444003_at lung-inducible neuralized-related C3HC4 RING domain protein Lincr 2.2464201 down 0.006752 1420967_at solute carrier family 25 (mitochondrial carrier ornithine transporter), member 15 Slc25a15 2.2455287 up 0.012327 1456738_s_at brain protein 16 Brp16 2.2451339 up 0.000311 1429780_at coiled-coil domain containing 39 Ccdc39 2.245037 down 0.010879 1420668_a_at Yip1 domain family, member 2 Yipf2 2.243806 up 0.008603 1441935_at ankyrin repeat, family A (RFXANK-like), 2 Ankra2 2.2438016 down 0.005676 1457687_at B-cell leukemia/lymphoma 2 /// similar to Bcl2-like protein Bcl2 /// LOC1000466 2.24306 up 0.004624 1452020_a_at SIVA1, apoptosis-inducing factor Siva1 2.2428138 down 0.004491 1438167_x_at Folliculin Flcn 2.2427604 up 0.000538 1423648_at protein disulfide isomerase associated 6 Pdia6 2.242565 down 0.003782 1424854_at histone cluster 1, H4i Hist1h4i 2.24212 up 0.006864 1424325_at establishment of cohesion 1 homolog 1 (S. cerevisiae) Esco1 2.2418675 down 0.013551 1422686_s_at exocyst complex component 4 Exoc4 2.2403927 up 0.001082 1428857_at Sin3A associated protein, 130kDa Sap130 2.2401958 up 0.003916 1424243_at RWD domain containing 4A Rwdd4a 2.2399373 up 0.002227 1453688_at CWF19-like 2, cell cycle control (S. pombe) Cwf19l2 2.2392237 down 0.022100 1459788_at G protein-coupled receptor 107 Gpr107 2.2389078 down 0.000048 1450292_a_at HORMA domain containing 1 /// similar to Nohma /// similar to HORMA domain containing 1 Hormad1 /// LOC667 2.2384038 down 0.005959 1435842_at N-acetyltransferase 8-like Nat8l 2.237863 up 0.000040 1421083_x_at barrier to autointegration factor 1 Banf1 2.2370763 down 0.000223 1452279_at complement factor properdin Cfp 2.2366104 down 0.005371 1427375_at RNA (guanine-9-) methyltransferase domain containing 2 /// similar to RNA (guanine-9-) methyltransferaLOC100045440 /// Rg 2.2351277 up 0.004346 1422896_at vesicle-associated membrane protein 4 Vamp4 2.233877 up 0.012602 1424464_s_at RIKEN cDNA 2210010L05 gene 2210010L05Rik 2.2333896 down 0.002995 1421265_a_at RNA binding motif protein 38 Rbm38 2.232969 down 0.005258 1436635_at ubiquitin-conjugating enzyme E2Z (putative) Ube2z 2.2328444 up 0.000620 1425701_a_at regulator of G-protein signaling 3 Rgs3 2.230321 down 0.000084 1423840_at coiled-coil domain containing 56 Ccdc56 2.2301373 down 0.010904 1428386_at acyl-CoA synthetase long-chain family member 3 Acsl3 2.2291152 up 0.005518 1419905_s_at hydroxyprostaglandin dehydrogenase 15 (NAD) Hpgd 2.2281814 down 0.001127 1436979_x_at RNA binding motif protein 14 Rbm14 2.2276144 up 0.004252 1450925_a_at ribosomal protein S27-like Rps27l 2.2265794 down 0.000017 1456106_x_at serologically defined colon cancer antigen 3 Sdccag3 2.226196 up 0.003531 1425654_a_at LIM domain and actin binding 1 Lima1 2.225406 up 0.013221 1439434_x_at SH2 domain containing 5 Sh2d5 2.2253964 down 0.003390 1436724_a_at ligatin Lgtn 2.224694 up 0.013521 1438076_at ribosomal protein L30 Rpl30 2.2244704 up 0.031781 1436067_at zinc finger and BTB domain containing 10 Zbtb10 2.2240176 up 0.002526 1447085_s_at nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 Nfatc1 2.222578 up 0.005865 1437776_at transmembrane and coiled coil domains 1 Tmcc1 2.2207556 down 0.019547 1439349_at strawberry notch homolog 2 (Drosophila) Sbno2 2.2197032 up 0.024342 1421845_at golgi phosphoprotein 3 Golph3 2.2192602 down 0.000156 1434350_at AXIN1 up-regulated 1 Axud1 2.219021 up 0.009740 1438573_at RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) Rmi1 2.2171326 up 0.007650 1434543_a_at bolA-like 2 (E. coli) Bola2 2.217024 down 0.000198 1438155_x_at phosphatidylinositol glycan anchor biosynthesis, class O Pigo 2.2165127 up 0.000008 1456226_x_at discoidin domain receptor family, member 1 Ddr1 2.216101 up 0.006828 1446991_at GCN1 general control of amino-acid synthesis 1-like 1 (yeast) Gcn1l1 2.2150447 up 0.018977 1434426_at non-SMC condensin II complex, subunit D3 Ncapd3 2.2142413 down 0.002573 1448007_at bromodomain adjacent to zinc finger domain, 2B Baz2b 2.2116492 down 0.000109 1437452_x_at voltage-dependent anion channel 1 Vdac1 2.211337 down 0.005915 1455327_at SUMO/sentrin specific peptidase 2 Senp2 2.2112727 up 0.013691 1453064_at Ewing's tumor-associated antigen 1 Etaa1 2.2107341 up 0.007856 1419816_s_at ERBB receptor feedback inhibitor 1 Errfi1 2.2104323 up 0.008086 1427491_at NOL1/NOP2/Sun domain family 6 Nsun6 2.209303 up 0.006627 1436023_at BCL2-associated transcription factor 1 Bclaf1 2.2087789 down 0.011499 1419552_at enoyl Coenzyme A hydratase domain containing 1 Echdc1 2.2085505 up 0.019900 1452532_x_at CEA-related cell adhesion molecule 1 Ceacam1 2.208206 down 0.001537 1417284_at mitogen-activated protein kinase associated protein 1 Mapkap1 2.2070794 up 0.000116 1440479_at Chromobox homolog 4 (Drosophila Pc class) /// 10 days lactation, adult female mammary gland cDNA, Cbx4 2.205941 up 0.003380 1415807_s_at splicing factor, arginine/serine-rich 2 (SC-35) Sfrs2 2.2056937 down 0.002498 1454846_at UTP15, U3 small nucleolar ribonucleoprotein, homolog (yeast) Utp15 2.204449 up 0.000471 1423314_s_at phosphodiesterase 7A Pde7a 2.2041888 down 0.001529 1436362_x_at CCR4 carbon catabolite repression 4-like (S. cerevisiae) /// RIKEN cDNA 2700079J08 gene /// similar to2700079J08Rik /// Cc 2.203097 down 0.001417 1442753_at tumor necrosis factor, alpha-induced protein 8 Tnfaip8 2.2018275 up 0.000160 1434836_at nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein Nfatc2ip 2.2017896 up 0.000598 1427033_at dynamin binding protein Dnmbp 2.2006655 up 0.015492 1449217_at caspase 8 associated protein 2 Casp8ap2 2.2000496 up 0.007510 1460643_at elongation factor RNA polymerase II Ell 2.1991904 up 0.002371 1440879_at ATP-binding cassette transporter sub-family A member 9 Abca9 2.199026 down 0.001620 1456081_a_at acetoacetyl-CoA synthetase Aacs 2.198842 up 0.001787 1456102_a_at cullin 5 Cul5 2.198622 down 0.001659 1437490_x_at UDP-N-acetylglucosamine pyrophosphorylase 1 /// similar to UDP-N-acetylhexosamine pyrophosphorylaLOC640502 /// Uap1 2.198616 up 0.000978 1423345_at degenerative spermatocyte homolog 1 (Drosophila) Degs1 2.1982615 down 0.000282 1418715_at pantothenate kinase 1 Pank1 2.1980646 up 0.000940 1420896_at synaptosomal-associated protein 23 Snap23 2.1973245 down 0.000042 1417289_at pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2 Plekha2 2.1969337 down 0.000224 1416253_at cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) /// similar to P19-Ink4d Cdkn2d /// LOC10004 2.196376 down 0.000010 1423749_s_at RAN GTPase activating protein 1 Rangap1 2.1961482 up 0.000097 1424339_at 2'-5' oligoadenylate synthetase-like 1 Oasl1 2.1960387 up 0.007989 1449052_a_at DNA methyltransferase 3B Dnmt3b 2.1958709 up 0.001423 1455184_at MOB1, Mps One Binder kinase activator-like 1A (yeast) Mobkl1a 2.194893 up 0.004393 1460521_a_at oligonucleotide/oligosaccharide-binding fold containing 2A Obfc2a 2.1947377 down 0.001399 1452238_at HIV-1 Rev binding protein Hrb 2.194699 up 0.030502 1418665_at inositol (myo)-1(or 4)-monophosphatase 2 Impa2 2.1937659 down 0.000168 1446861_at glucosamine (N-acetyl)-6-sulfatase Gns 2.1936228 up 0.010966 1456696_x_at RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) Rmi1 2.1933396 up 0.001093 1422431_at melanoma antigen, family E, 1 Magee1 2.1930003 up 0.004210 1437035_x_at ring finger protein 14 Rnf14 2.1929293 up 0.000484 1428579_at formin-like 2 Fmnl2 2.1929154 up 0.000177 1427548_a_at chloride channel, nucleotide-sensitive, 1A Clns1a 2.1928568 down 0.000102 1428348_at GDNF-inducible zinc finger protein 1 Gzf1 2.1916277 up 0.001264 1422499_at LIM domain and actin binding 1 Lima1 2.1912918 up 0.006515 1420023_at eukaryotic translation termination factor 1 Etf1 2.1899965 up 0.000020 1429128_x_at nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 Nfkb2 2.189924 up 0.003207 1451286_s_at fusion, derived from t(12;16) malignant liposarcoma (human) Fus 2.189615 up 0.000884 1459735_at FK506 binding protein 15 Fkbp15 2.1894348 up 0.002275 1437074_at sorting nexin 5 Snx5 2.189062 up 0.000225 1435416_x_at phosphatidylinositol glycan anchor biosynthesis, class Q Pigq 2.1889234 up 0.000013 1431394_a_at leucine-rich repeat kinase 2 Lrrk2 2.188634 down 0.008173 1423488_at monocyte to macrophage differentiation-associated Mmd 2.1880133 up 0.021338 1429486_at 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 Hbb-b1 /// Hbb-b2 2.187022 up 0.005491 1426863_at RNA binding motif protein, X chromosome Rbmx 2.1857915 up 0.004199 1415828_a_at DNA segment, Chr 3, University of California at Los Angeles 1 D3Ucla1 2.1853566 down 0.000032 1457264_at PHD finger protein 20-like 1 Phf20l1 2.1850545 down 0.000653 1434148_at transcription factor 4 Tcf4 2.1841767 up 0.003226 1450378_at TAP binding protein Tapbp 2.1840134 down 0.000032 1430021_a_at SUMO1 activating enzyme subunit 1 Sae1 2.1829786 down 0.008381 1428466_at chromodomain helicase DNA binding protein 3 Chd3 2.1827383 up 0.006477 1433930_at heparanase Hpse 2.1822472 down 0.000680 1427274_at ring finger protein 214 Rnf214 2.1817913 up 0.000042 1428725_at protein inhibitor of activated STAT 2 Pias2 2.181112 up 0.030376 1422875_at CD84 antigen Cd84 2.1806407 down 0.002834 1429189_at arylsulfatase B Arsb 2.1805844 up 0.003444 1422603_at ribonuclease, RNase A family 4 Rnase4 2.1802025 down 0.000013 1426690_a_at sterol regulatory element binding factor 1 Srebf1 2.179786 up 0.000013 1421170_a_at phospholipase C, beta 1 Plcb1 2.1795244 down 0.000020 1429188_at COX11 homolog, cytochrome c oxidase assembly protein (yeast) Cox11 2.1790793 up 0.002484 1421940_at stromal antigen 1 /// similar to Stromal antigen 1 LOC100045442 /// St 2.1788108 down 0.000397 1451185_at splicing factor 3b, subunit 5 Sf3b5 2.178442 down 0.002502 1437203_at Casitas B-lineage lymphoma-like 1 Cbll1 2.178069 up 0.000667 1430835_at coiled-coil domain containing 125 Ccdc125 2.1777775 up 0.012862 1437258_at small proline-rich protein 2A /// similar to ribosomal protein L21 LOC100042999 /// LO 2.1773536 down 0.003491 1424484_at MOB1, Mps One Binder kinase activator-like 1B (yeast) Mobkl1b 2.1767607 down 0.000552 1425482_s_at ankyrin repeat and MYND domain containing 2 Ankmy2 2.1766298 up 0.000140 1419564_at zinc finger protein 467 Zfp467 2.1765645 up 0.000576 1438619_x_at zinc finger, DHHC domain containing 14 Zdhhc14 2.1755078 up 0.006662 1429238_a_at 2-oxoglutarate and iron-dependent oxygenase domain containing 2 Ogfod2 2.1752467 up 0.033424 1421546_a_at Rac GTPase-activating protein 1 Racgap1 2.1750333 down 0.029868 1422509_at U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1 /// similar to U2 snrnp auxiliary factor, small LOC100040029 /// LO 2.173866 up 0.000038 1418997_at LYR motif containing 5 Lyrm5 2.1735342 up 0.010038 1418194_at UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 Galnt10 2.1733928 down 0.002515 1417876_at Fc receptor, IgG, high affinity I Fcgr1 2.1732726 down 0.008672 1444155_at ninein Nin 2.1732626 down 0.016092 1430403_at ubiquitin specific peptidase 32 Usp32 2.1730256 down 0.000070 1430980_a_at eukaryotic translation initiation factor 4A1 Eif4a1 2.172984 down 0.000217 1434678_at muscleblind-like 3 (Drosophila) Mbnl3 2.1721094 up 0.004206 1437495_at similar to zinc finger, X-linked, duplicated B /// Yy2 transcription factor LOC100047187 /// Yy 2.1718166 up 0.006226 1455836_at poly (A) polymerase alpha Papola 2.1713786 down 0.001216 1427736_a_at chemokine (C-C motif) receptor-like 2 Ccrl2 2.1712236 up 0.011257 1460004_x_at syntaxin 6 Stx6 2.170948 up 0.001197 1450872_s_at lysosomal acid lipase A Lipa 2.1707873 up 0.000335 1456350_at zinc finger protein 451 Zfp451 2.1706402 up 0.029827 1426871_at F-box protein 33 Fbxo33 2.1697474 up 0.000253 1454836_at transmembrane protein 18 Tmem18 2.1695185 up 0.012949 1437234_x_at protein arginine N-methyltransferase 2 Prmt2 2.1692634 up 0.000208 1436891_at ubiquitin specific peptidase 15 Usp15 2.169196 up 0.010449 1430077_at splicing factor, arginine/serine-rich 11 Sfrs11 2.1690762 up 0.004446 1438855_x_at tumor necrosis factor, alpha-induced protein 2 Tnfaip2 2.1686347 up 0.000418 1448278_at XPA binding protein 2 Xab2 2.1675067 down 0.001503 1444647_at phospholipase A2, activating protein Plaa 2.167427 down 0.004298 1417726_at Sjogren's syndrome/scleroderma autoantigen 1 homolog (human) Sssca1 2.1668198 down 0.003191 1460735_at supervillin Svil 2.1666558 up 0.004681 1434499_a_at lactate dehydrogenase B Ldhb 2.1659455 up 0.015484 1436892_at sprouty-related, EVH1 domain containing 2 Spred2 2.1647096 up 0.011845 1432052_at Exosome component 1 Exosc1 2.1634495 up 0.000174 1455486_at protein inhibitor of activated STAT 1 Pias1 2.1633942 up 0.000205 1419074_at ChaC, cation transport regulator homolog 2 (E. coli) Chac2 2.1628857 up 0.004365 1430575_a_at tripeptidyl peptidase II Tpp2 2.1625447 down 0.000493 1429187_at transmembrane emp24 protein transport domain containing 7 Tmed7 2.1624033 down 0.000278 1422557_s_at metallothionein 1 Mt1 2.1623805 up 0.015178 1428306_at DNA-damage-inducible transcript 4 Ddit4 2.1611087 up 0.013661 1418451_at guanine nucleotide binding protein (G protein), gamma 2 subunit Gng2 2.1608343 down 0.000029 1449840_at syntrophin, basic 2 Sntb2 2.160091 up 0.000072 1425570_at signaling lymphocytic activation molecule family member 1 Slamf1 2.1596198 up 0.020957 1433702_at endoplasmic reticulum metallopeptidase 1 Ermp1 2.1580322 up 0.000118 1453424_at FYVE and coiled-coil domain containing 1 Fyco1 2.157466 up 0.027582 1425837_a_at CCR4 carbon catabolite repression 4-like (S. cerevisiae) /// similar to carbon catabolite repression 4 pro Ccrn4l /// LOC100047 2.1574333 up 0.003309 1456080_a_at serine incorporator 3 Serinc3 2.157091 down 0.000118 1426301_at activated leukocyte cell adhesion molecule Alcam 2.156378 down 0.001796 1434544_at bolA-like 2 (E. coli) Bola2 2.156063 down 0.000348 1449550_at myosin IC Myo1c 2.1551526 up 0.000763 1439302_at ubiquitin-activating enzyme E1-like 2 Ube1l2 2.155107 up 0.011723 1448997_at pleckstrin homology, Sec7 and coiled-coil domains 1 Pscd1 2.1550884 down 0.008699 1421116_a_at reticulon 4 Rtn4 2.1534579 down 0.000336 1460674_at progestin and adipoQ receptor family member VII Paqr7 2.1533206 down 0.000671 1430744_at napsin A aspartic peptidase Napsa 2.1523008 up 0.003545 1450100_a_at transcription elongation regulator 1 (CA150) Tcerg1 2.1520317 down 0.014856 1416429_a_at catalase Cat 2.151655 up 0.000271 1428174_x_at KH-type splicing regulatory protein Khsrp 2.1510086 up 0.000601 1445206_at ZW10 homolog (Drosophila), centromere/kinetochore protein Zw10 2.1504433 up 0.026070 1424970_at purine-rich element binding protein G Purg 2.1473703 up 0.005629 1418293_at interferon-induced protein with tetratricopeptide repeats 2 Ifit2 2.147076 up 0.026919 1421905_at trimethylguanosine synthase homolog (S. cerevisiae) Tgs1 2.1467488 down 0.032755 1429035_at dipeptidase 3 Dpep3 2.1464794 down 0.015205 1432187_at nucleoporin 43 Nup43 2.1457436 up 0.027596 1442058_s_at proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein Psmc3ip 2.1454191 down 0.001411 1449659_s_at M-phase phosphoprotein 9 Mphosph9 2.1447566 up 0.024616 1436197_at CDC42 binding protein kinase gamma (DMPK-like) Cdc42bpg 2.1441398 up 0.000469 1450104_at a disintegrin and metallopeptidase domain 10 Adam10 2.1436248 down 0.001600 1439436_x_at inner centromere protein Incenp 2.143587 up 0.000027 1427115_at myosin, heavy polypeptide 3, skeletal muscle, embryonic Myh3 2.1434252 down 0.005387 1428585_at actinin, alpha 1 Actn1 2.1421282 up 0.003591 1439326_at leucyl/cystinyl aminopeptidase Lnpep 2.1401777 up 0.021512 1438096_a_at deoxythymidylate kinase Dtymk 2.139909 up 0.001040 1436766_at LUC7-like 2 (S. cerevisiae) Luc7l2 2.139175 down 0.006632 1428057_a_at AHNAK nucleoprotein (desmoyokin) Ahnak 2.1382842 down 0.002760 1450905_at plexin C1 Plxnc1 2.1376398 up 0.019331 1422527_at histocompatibility 2, class II, locus DMa H2-DMa 2.1362357 down 0.000253 1434307_at transmembrane protein 64 Tmem64 2.1357062 up 0.002696 1438067_at neurofibromatosis 1 Nf1 2.1356106 up 0.023444 1418778_at coiled-coil domain containing 109B Ccdc109b 2.1353576 down 0.000994 1427567_a_at tropomyosin 3, gamma Tpm3 2.1344347 down 0.000294 1453561_x_at RIKEN cDNA 8430431K14 gene 8430431K14Rik 2.1341534 down 0.000755 1430172_a_at cytochrome P450, family 4, subfamily f, polypeptide 16 /// cytochrome P450, family 4, subfamily f, polyp Cyp4f16 /// Cyp4f37 2.1339324 down 0.000072 1422768_at synaptotagmin binding, cytoplasmic RNA interacting protein Syncrip 2.1330495 up 0.018666 1421121_at A kinase (PRKA) anchor protein 10 Akap10 2.1328528 down 0.009596 1431792_a_at serine/threonine kinase 11 interacting protein /// similar to serine/threonine kinase 11 interacting protein LOC100047492 /// St 2.1326153 up 0.000014 1436189_at NAD(P)H dehydrogenase, quinone 2 Nqo2 2.1324997 up 0.000363 1437067_at putative homeodomain transcription factor 2 Phtf2 2.1323066 up 0.001879 1422066_x_at killer cell lectin-like receptor subfamily B member 1D Klrb1d 2.1312304 down 0.012216 1435181_at lin-54 homolog (C. elegans) Lin54 2.13043 up 0.001617 1427058_at eukaryotic translation initiation factor 4A1 Eif4a1 2.1301172 down 0.000326 1418238_at isovaleryl coenzyme A dehydrogenase Ivd 2.1283586 up 0.000961 1439943_at vacuolar protein sorting 54 (yeast) Vps54 2.12687 down 0.024227 1451941_a_at Fc receptor, IgG, low affinity IIb Fcgr2b 2.1266913 down 0.005046 1435429_x_at ribosomal protein S27-like Rps27l 2.1263652 down 0.000004 1422931_at fos-like antigen 2 Fosl2 2.1254468 up 0.000460 1430594_at RAB11 family interacting protein 1 (class I) Rab11fip1 2.1249614 up 0.001047 1426968_a_at retinol dehydrogenase 10 (all-trans) Rdh10 2.1245737 up 0.000826 1451750_at interleukin-1 receptor-associated kinase 4 Irak4 2.1245513 up 0.000773 1449410_a_at growth arrest specific 5 Gas5 2.1241076 down 0.000023 1449580_s_at histocompatibility 2, class II, locus Mb1 /// histocompatibility 2, class II, locus Mb2 H2-DMb1 /// H2-DMb2 2.1235642 down 0.001065 1447636_x_at transmembrane and coiled-coil domains 4 Tmco4 2.1235354 up 0.000002 1435588_at WD repeat and FYVE domain containing 1 Wdfy1 2.123506 up 0.006562 1434260_at FCH and double SH3 domains 2 Fchsd2 2.1234744 up 0.018759 1428513_at calcium binding and coiled coil domain 1 Calcoco1 2.123146 up 0.005236 1434833_at Mitogen activated protein kinase kinase kinase kinase 2 Map4k2 2.1226687 up 0.000610 1449861_at NIMA (never in mitosis gene a)-related expressed kinase 4 Nek4 2.1223278 up 0.022130 1459712_at zinc finger protein 182 Zfp182 2.1222844 up 0.027149 1436108_at thioredoxin domain containing 9 Txndc9 2.1220334 up 0.030423 1449934_at purine rich element binding protein A /// similar to hCG45299 LOC100045958 /// Pu 2.1220222 up 0.000802 1423398_at TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor Taf12 2.1214 down 0.000279 1439695_a_at M-phase phosphoprotein 1 Mphosph1 2.120299 up 0.006540 1429369_at transportin 3 Tnpo3 2.119002 down 0.000102 1423508_at MYST histone acetyltransferase monocytic leukemia 4 Myst4 2.1189818 up 0.001169 1441639_at zinc finger, CCHC domain containing 8 Zcchc8 2.1188886 up 0.005179 1416976_at signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 Stam2 2.1182828 up 0.001246 1419924_at Folliculin interacting protein 1 Fnip1 2.118119 up 0.008682 1435795_at galactosidase, beta 1 Glb1 2.1179 up 0.006911 1420951_a_at Son cell proliferation protein Son 2.1174514 down 0.000058 1455075_at phosphatidylinositol glycan anchor biosynthesis, class V Pigv 2.1171846 up 0.000020 1416862_at signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 Stam 2.1169105 up 0.002983 1459861_s_at F-box and leucine-rich repeat protein 10 /// similar to F-box and leucine-rich repeat protein 10 Fbxl10 /// LOC100039 2.1163795 up 0.005700 1434079_s_at minichromosome maintenance deficient 2 mitotin (S. cerevisiae) Mcm2 2.1155765 up 0.000228 1417287_at histocompatibility 13 H13 2.1150424 down 0.000059 1424830_at cyclin K /// similar to cyclin K Ccnk /// LOC1000466 2.1145258 up 0.013429 1443396_at survival motor neuron domain containing 1 /// similar to survival motor neuron domain containing 1 LOC545792 /// LOC6 2.1140177 up 0.000375 1423265_at multiple inositol polyphosphate histidine phosphatase 1 Minpp1 2.1138208 up 0.003314 1429491_s_at Rap1 interacting factor 1 homolog (yeast) Rif1 2.1137397 up 0.002092 1455220_at frequently rearranged in advanced T-cell lymphomas 2 Frat2 2.1124141 up 0.004093 1436797_a_at surfeit gene 4 Surf4 2.1122968 down 0.000086 1417668_at reticulon 4 interacting protein 1 Rtn4ip1 2.1118467 up 0.002238 1428890_at fem-1 homolog c (C.elegans) Fem1c 2.1118333 up 0.015481 1427897_s_at suppressor of defective silencing 3 homolog (S. cerevisiae) Suds3 2.1117132 up 0.005833 1422478_a_at acyl-CoA synthetase short-chain family member 2 Acss2 2.1112528 up 0.000760 1424754_at membrane-spanning 4-domains, subfamily A, member 7 Ms4a7 2.110829 up 0.012883 1430827_a_at PTK2 protein tyrosine kinase 2 Ptk2 2.1106412 down 0.006845 1448619_at 7-dehydrocholesterol reductase Dhcr7 2.1097403 up 0.005872 1418526_at FUS interacting protein (serine-arginine rich) 1 /// similar to FUS interacting protein (serine-arginine rich)Fusip1 /// LOC63023 2.1093779 up 0.001499 1435465_at kelch repeat and BTB (POZ) domain containing 11 Kbtbd11 2.1093192 up 0.001287 1423748_at pyruvate dehydrogenase kinase, isoenzyme 1 Pdk1 2.10912 up 0.000431 1420618_at cytoplasmic polyadenylation element binding protein 4 Cpeb4 2.1085496 up 0.001351 1440684_at acyltransferase like 1 Aytl1 2.108498 up 0.001542 1433649_at amine oxidase, flavin containing 1 Aof1 2.1084661 up 0.001892 1428752_at solute carrier family 5 (sodium/glucose cotransporter), member 11 Slc5a11 2.1081796 up 0.025102 1437181_at pellino 2 Peli2 2.1080892 up 0.012171 1430778_a_at nucleotide binding protein 1 Nubp1 2.1076775 down 0.000474 1457528_at solute carrier family 4, sodium bicarbonate cotransporter, member 7 Slc4a7 2.107171 down 0.014911 1436351_at coenzyme Q3 homolog, methyltransferase (yeast) Coq3 2.1069071 up 0.002061 1451036_at spastic paraplegia 21 homolog (human) /// similar to spastic paraplegia 21 homolog LOC100048562 /// Sp 2.1066425 down 0.001285 1442793_s_at transforming growth factor beta regulated gene 4 /// similar to Transforming growth factor beta regulatedLOC100046166 /// Tb 2.105349 up 0.000001 1417078_at lectin, galactose-binding, soluble 2 Lgals2 2.1044602 down 0.005072 1415992_at phosphatidylinositol glycan anchor biosynthesis, class O Pigo 2.1043522 up 0.009683 1418302_at palmitoyl-protein thioesterase 2 Ppt2 2.1042361 up 0.000018 1425001_at ring finger protein 146 Rnf146 2.1038876 up 0.008752 1425358_at RIO kinase 1 (yeast) Riok1 2.1034358 up 0.013227 1438487_s_at zinc finger, ZZ domain containing 3 Zzz3 2.1015184 up 0.011783 1460627_at thrombospondin, type I, domain containing 7B Thsd7b 2.10136 down 0.002871 1451111_at nucleoporin 133 Nup133 2.1012428 down 0.024735 1420867_at transmembrane emp24 domain trafficking protein 2 /// similar to transmembrane protein LOC100042343 /// Tm 2.1010613 down 0.000574 1422653_at centrosomal protein 70 Cep70 2.1009517 up 0.004345 1454889_x_at transmembrane and coiled coil domains 3 Tmcc3 2.1009226 up 0.027995 1423090_x_at SEC61, gamma subunit /// similar to SEC61 gamma LOC100042561 /// LO 2.1000354 down 0.000297 1450883_a_at CD36 antigen Cd36 2.0998049 up 0.000557 1424685_at exosome component 4 Exosc4 2.0995398 down 0.001394 1424981_at neurolysin (metallopeptidase M3 family) Nln 2.0994954 up 0.000271 1435476_a_at Fc receptor, IgG, low affinity IIb Fcgr2b 2.0992067 down 0.006398 1447754_x_at THAP domain containing 4 Thap4 2.0987349 up 0.000144 1419872_at colony stimulating factor 1 receptor Csf1r 2.098402 down 0.001618 1452187_at RNA binding motif protein 5 Rbm5 2.096705 down 0.000469 1434185_at acetyl-Coenzyme A carboxylase alpha /// hypothetical protein LOC100043671 Acaca /// LOC100043 2.0965912 up 0.000075 1429109_at male-specific lethal 2-like 1 (Drosophila) Msl2l1 2.0959704 up 0.000347 1426064_at cytochrome P450, family 3, subfamily a, polypeptide 44 Cyp3a44 2.0958984 down 0.003060 1423182_at tumor necrosis factor receptor superfamily, member 13b Tnfrsf13b 2.095717 down 0.001026 1427781_at upregulated during skeletal muscle growth 2 Usmg2 2.0951777 down 0.006495 1426580_at polo-like kinase 4 (Drosophila) Plk4 2.0945232 down 0.032822 1424384_a_at zinc and ring finger 1 Znrf1 2.0942788 up 0.009316 1444158_at jumonji, AT rich interactive domain 1C (Rbp2 like) Jarid1c 2.0941465 up 0.000830 1428484_at oxysterol binding protein-like 3 Osbpl3 2.093602 up 0.000727 1452869_at PRP38 pre-mRNA processing factor 38 (yeast) domain containing B Prpf38b 2.0933838 up 0.000903 1417122_at vav 3 oncogene Vav3 2.0928278 up 0.000360 1436153_a_at zinc finger, MYND domain containing 11 Zmynd11 2.0928137 up 0.000411 1460430_at RAP2C, member of RAS oncogene family /// similar to RAP2C, member of RAS oncogene family LOC100047558 /// Ra 2.0924168 up 0.000141 1429108_at male-specific lethal 2-like 1 (Drosophila) Msl2l1 2.091966 up 0.000419 1439247_at dedicator of cytokinesis 10 Dock10 2.0916092 down 0.007391 1430742_a_at spermatogenesis associated 16 Spata16 2.0901496 down 0.006363 1418042_a_at ATP-binding cassette, sub-family C (CFTR/MRP), member 5 Abcc5 2.0900335 up 0.001564 1417025_at histocompatibility 2, class II antigen E beta H2-Eb1 2.0896497 down 0.003488 1438971_x_at ubiquitin-conjugating enzyme E2H Ube2h 2.0896482 up 0.000092 1459783_s_at cappuccino Cno 2.0886443 up 0.000675 1455802_x_at anterior gradient 2 (Xenopus laevis) Agr2 2.0849953 down 0.005604 1434805_at myeloid/lymphoid or mixed lineage-leukemia translocation to 1 homolog (Drosophila) Mllt1 2.084842 up 0.008384 1456259_at integrator complex subunit 10 /// similar to integrator complex subunit 10 Ints10 /// LOC674888 2.0848296 up 0.003972 1440310_at Runt-related transcription factor 1; translocated to, 1 (cyclin D-related) Runx1t1 2.0846698 down 0.015916 1437113_s_at phospholipase D1 Pld1 2.0842977 up 0.001311 1415760_s_at ATX1 (antioxidant protein 1) homolog 1 (yeast) Atox1 2.0842018 down 0.000153 1434384_at nuclear receptor interacting protein 1 Nrip1 2.083593 up 0.014828 1418536_at histocompatibility 2, Q region locus 7 /// histocompatibility 2, Q region locus 8 /// histocompatibility 2, Q rH2-Q6 /// H2-Q7 /// H2 2.0828106 up 0.011570 1457680_a_at transmembrane protein 69 Tmem69 2.0826745 up 0.004855 1452699_at methyltransferase 11 domain containing 1 Mett11d1 2.0824149 up 0.031668 1427988_s_at scaffold attachment factor B2 Safb2 2.0823302 up 0.000181 1421198_at integrin alpha V Itgav 2.0822394 down 0.014814 1460659_at Phosphatidylinositol transfer protein, beta Pitpnb 2.0822268 up 0.000056 1428130_at lectin, mannose-binding, 1 Lman1 2.081413 down 0.007391 1428868_a_at ornithine decarboxylase antizyme /// similar to ornithine decarboxylase antizyme LOC100041965 /// LO 2.081217 down 0.000073 1448223_at fat mass and obesity associated Fto 2.0811152 up 0.012547 1436011_at engulfment and cell motility 2, ced-12 homolog (C. elegans) Elmo2 2.0810463 up 0.006685 1425711_a_at thymoma viral proto-oncogene 1 /// similar to serine/threonine protein kinase Akt1 /// LOC1000476 2.0809693 down 0.000021 1452146_a_at COX15 homolog, cytochrome c oxidase assembly protein (yeast) Cox15 2.0805748 up 0.005599 1418258_s_at dynein light chain LC8-type 2 Dynll2 2.0804865 up 0.000237 1433486_at chloride channel 3 Clcn3 2.080242 up 0.000778 1451940_x_at triadin Trdn 2.0798078 down 0.004489 1451819_at zinc finger, SWIM domain containing 6 Zswim6 2.0796244 down 0.024988 1426304_x_at xylosylprotein beta1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I) B4galt7 2.079283 up 0.001229 1458462_at Rho GTPase activating protein 30 Arhgap30 2.0791378 up 0.001189 1433591_at protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) Ppp3r1 2.0791378 up 0.000065 1455920_x_at lysozyme-like 6 Lyzl6 2.0790937 down 0.002206 1460001_at pyroglutamyl-peptidase I Pgpep1 2.0788891 up 0.010281 1449932_at casein kinase 1, delta Csnk1d 2.0783367 up 0.000311 1452991_at chromodomain helicase DNA binding protein 2 Chd2 2.078279 up 0.004382 1450815_s_at coiled-coil-helix-coiled-coil-helix domain containing 2 /// RIKEN cDNA 2410018M08 gene /// similar to co2410018M08Rik /// C 2.0779839 down 0.001962 1424110_a_at expressed in non-metastatic cells 1, protein /// similar to Nucleoside diphosphate kinase A (NDK A) (ND LOC100046344 /// Nm 2.077775 down 0.000562 1434610_at plectin 1 Plec1 2.0769799 down 0.009383 1425687_at CASP8 and FADD-like apoptosis regulator Cflar 2.0767817 down 0.008981 1434511_at phosphorylase kinase beta Phkb 2.076406 up 0.001859 1418625_s_at glyceraldehyde-3-phosphate dehydrogenase /// RIKEN cDNA 3000002C10 gene /// predicted gene, EG43000002C10Rik /// EG 2.0762687 down 0.000285 1451053_a_at transformed mouse 3T3 cell double minute 1 Mdm1 2.0762537 up 0.006080 1428214_at translocase of outer mitochondrial membrane 7 homolog (yeast) Tomm7 2.0752177 down 0.000115 1427142_s_at jumonji, AT rich interactive domain 1B (Rbp2 like) Jarid1b 2.0752075 up 0.001191 1424398_at DEAH (Asp-Glu-Ala-His) box polypeptide 36 Dhx36 2.0750957 down 0.029849 1452647_a_at DPH2 homolog (S. cerevisiae) Dph2 2.0727513 up 0.001750 1417139_at DSN1, MIND kinetochore complex component, homolog (S. cerevisiae) Dsn1 2.0726137 up 0.003426 1458996_at integrin alpha 5 (fibronectin receptor alpha) Itga5 2.0718958 up 0.032332 1418230_a_at LIM and senescent cell antigen-like domains 1 Lims1 2.0711694 down 0.030288 1438449_at Cdc42 binding protein kinase alpha Cdc42bpa 2.0710223 down 0.002268 1450767_at neural precursor cell expressed, developmentally down-regulated gene 9 Nedd9 2.0710065 down 0.002536 1417104_at epithelial membrane protein 3 Emp3 2.0701592 down 0.000986 1426983_at formin binding protein 1 Fnbp1 2.0692399 up 0.000189 1456261_at SH3-domain kinase binding protein 1 Sh3kbp1 2.0692124 up 0.002088 1447522_s_at tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 Tnks2 2.068946 up 0.003539 1418513_at serine/threonine kinase 3 (Ste20, yeast homolog) Stk3 2.068794 down 0.000477 1447476_at ATP-binding cassette, sub-family C (CFTR/MRP), member 10 Abcc10 2.0687037 up 0.000039 1428240_at neurexin I Nrxn1 2.0686853 up 0.006140 1452787_a_at protein arginine N-methyltransferase 1 Prmt1 2.0685422 up 0.000029 1451465_at ubiquitin-like 7 (bone marrow stromal cell-derived) Ubl7 2.0681841 up 0.000308 1417563_at eukaryotic translation initiation factor 4E binding protein 1 Eif4ebp1 2.0681825 up 0.000439 1440905_at Heparan sulfate 2-O-sulfotransferase 1 Hs2st1 2.066989 up 0.015205 1422824_s_at epidermal growth factor receptor pathway substrate 8 Eps8 2.0665278 up 0.007311 1449113_at GC-rich promoter binding protein 1-like 1 Gpbp1l1 2.0663583 up 0.000519 1453472_a_at SLAM family member 7 Slamf7 2.0663114 down 0.012320 1424014_at RIKEN cDNA 2900092E17 gene 2900092E17Rik 2.0661466 down 0.000104 1423483_s_at TATA box binding protein (Tbp)-associated factor, RNA polymerase I, C Taf1c 2.0659814 up 0.000220 1430326_s_at ubiquinol-cytochrome c reductase, complex III subunit VII Uqcrq 2.0643747 down 0.000005 1455841_s_at glutamate-rich WD repeat containing 1 Grwd1 2.0637982 up 0.021691 1445305_at Solute carrier family 10 (sodium/bile acid cotransporter family), member 7 Slc10a7 2.0634162 up 0.000921 1428578_s_at protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 Ppfia4 2.0629683 down 0.000064 1459764_x_at Activated spleen cDNA, RIKEN full-length enriched library, clone:F830018F16 product:hypothetical proteSnx10 2.0625598 down 0.019656 1438089_a_at BCL2-associated transcription factor 1 Bclaf1 2.062517 down 0.001553 1419454_x_at protein inhibitor of activated STAT 2 Pias2 2.0624025 up 0.007679 1423720_a_at SAR1 gene homolog A (S. cerevisiae) Sar1a 2.0604756 down 0.000038 1428893_at oxysterol binding protein-like 7 Osbpl7 2.059825 up 0.000677 1448297_a_at tyrosine kinase, non-receptor, 2 Tnk2 2.059012 up 0.000416 1439347_at tensin 4 Tns4 2.0586858 down 0.001367 1423152_at vesicle-associated membrane protein, associated protein B and C Vapb 2.0583737 up 0.017018 1418458_at anaphase promoting complex subunit 7 Anapc7 2.0583286 up 0.000361 1419810_x_at Rho GTPase activating protein 9 Arhgap9 2.058032 up 0.000127 1425747_at dedicator of cytokinesis 5 Dock5 2.0577776 up 0.012224 1447720_x_at protein kinase, cAMP dependent, catalytic, alpha Prkaca 2.0568693 up 0.001057 1457246_at retinoic acid induced 16 Rai16 2.0566545 up 0.000018 1439141_at G protein-coupled receptor 18 Gpr18 2.0563838 down 0.001552 1434044_at replication initiator 1 Repin1 2.0563023 up 0.015095 1429003_at SNW domain containing 1 Snw1 2.055953 down 0.010215 1456324_at zinc finger protein 748 Zfp748 2.055949 up 0.000299 1417559_at sideroflexin 1 Sfxn1 2.0554578 up 0.001194 1457111_at expressed sequence AA415038 AA415038 2.0551255 down 0.000369 1456590_x_at aldo-keto reductase family 1, member B3 (aldose reductase) Akr1b3 2.0548594 up 0.000808 1418004_a_at transmembrane protein 176B Tmem176b 2.0542698 down 0.029955 1447277_s_at prenylcysteine oxidase 1 Pcyox1 2.0540757 up 0.000114 1430328_at polymerase (RNA) III (DNA directed) polypeptide F Polr3f 2.0533807 up 0.000834 1431222_at T-cell lymphoma invasion and metastasis 2 Tiam2 2.0532856 down 0.017233 1428478_at receptor accessory protein 4 Reep4 2.0519736 up 0.000324 1417980_a_at insulin induced gene 2 Insig2 2.0512655 up 0.000946 1419817_s_at ankyrin repeat and zinc finger domain containing 1 Ankzf1 2.0507748 up 0.005476 1426172_a_at CD209a antigen Cd209a 2.0504549 down 0.008391 1419382_a_at dehydrogenase/reductase (SDR family) member 4 Dhrs4 2.0502908 down 0.001657 1419384_at protein interacting with C kinase 1 Pick1 2.050034 up 0.000438 1424863_a_at homeodomain interacting protein kinase 2 Hipk2 2.049895 up 0.016183 1428512_at basic helix-loop-helix domain containing, class B9 Bhlhb9 2.0497458 up 0.000154 1436077_a_at FCH domain only 1 Fcho1 2.0497022 up 0.017493 1428850_x_at CD99 antigen Cd99 2.0495186 up 0.000002 1455151_at A kinase (PRKA) anchor protein (yotiao) 9 Akap9 2.0489774 down 0.002300 1426310_at zinc finger, DHHC domain containing 5 Zdhhc5 2.048856 down 0.007237 1424570_at DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 /// similar to Probable ATP-dependent RNA helicase DDX4Ddx46 /// LOC100046 2.0484986 down 0.012639 1434545_x_at bolA-like 2 (E. coli) Bola2 2.048489 down 0.000208 1447448_s_at Kruppel-like factor 6 Klf6 2.04847 up 0.001566 1460295_s_at interleukin 6 signal transducer Il6st 2.0478425 down 0.005776 1427650_a_at runt related transcription factor 1 Runx1 2.0476315 up 0.015992 1416704_at mitogen activated protein kinase 14 Mapk14 2.0472896 down 0.000629 1416982_at forkhead box O1 Foxo1 2.0470352 up 0.013609 1448159_at RAB7, member RAS oncogene family Rab7 2.0463765 down 0.000014 1447778_x_at BRCA1/BRCA2-containing complex, subunit 3 Brcc3 2.046296 up 0.030229 1438992_x_at activating transcription factor 4 Atf4 2.0459828 up 0.008178 1437016_x_at RAP2C, member of RAS oncogene family /// similar to RAP2C, member of RAS oncogene family LOC100047558 /// Ra 2.0439348 up 0.000004 1426978_at kelch-like 2, Mayven (Drosophila) Klhl2 2.043597 up 0.000867 1447742_at lysosomal-associated protein transmembrane 5 Laptm5 2.0434928 up 0.001312 1456141_x_at BRCA1/BRCA2-containing complex, subunit 3 Brcc3 2.043202 up 0.004699 1426370_at male sterility domain containing 2 Mlstd2 2.043115 down 0.000433 1427773_a_at Rab acceptor 1 (prenylated) Rabac1 2.0423384 down 0.000067 1451845_a_at peptidyl-tRNA hydrolase 2 Ptrh2 2.0414834 down 0.000835 1423801_a_at adenine phosphoribosyl transferase Aprt 2.040437 down 0.000276 1460180_at hexosaminidase B Hexb 2.0398788 down 0.000087 1426303_at xylosylprotein beta1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I) B4galt7 2.039558 up 0.000413 1425363_at beta-1,4-N-acetyl-galactosaminyl transferase 1 B4galnt1 2.038813 up 0.000010 1436729_at actin filament associated protein 1 Afap1 2.0387113 up 0.006586 1456772_at neutrophil cytosolic factor 1 Ncf1 2.0383394 down 0.000324 1416080_at a disintegrin and metallopeptidase domain 15 (metargidin) Adam15 2.037952 down 0.022235 1426805_at SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Smarca4 2.0371761 down 0.024319 1437488_at solute carrier family 9 (sodium/hydrogen exchanger), isoform 9 Slc9a9 2.0364842 down 0.000000 1421129_a_at ATPase, Ca++ transporting, ubiquitous Atp2a3 2.0363595 up 0.001739 1434063_at zinc finger protein 664 Zfp664 2.0361013 up 0.000178 1436538_at ankyrin repeat domain 37 Ankrd37 2.0356658 up 0.001302 1418220_at forkhead box F2 Foxf2 2.0347474 down 0.014594 1428145_at acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) Acaa2 2.034394 up 0.000340 1426529_a_at transgelin 2 Tagln2 2.0341022 down 0.030855 1456103_at promyelocytic leukemia Pml 2.0338602 up 0.011052 1435866_s_at histone cluster 3, H2a Hist3h2a 2.0327406 up 0.000327 1457568_at heterogeneous nuclear ribonucleoprotein D Hnrpd 2.032091 up 0.005268 1438951_x_at nucleoporin 54 /// hypothetical protein LOC100042745 /// hypothetical protein LOC100047437 LOC100042745 /// LO 2.0320003 up 0.005266 1416605_at nucleolar protein family A, member 2 Nola2 2.0315838 down 0.000125 1421411_at proline-serine-threonine phosphatase-interacting protein 2 Pstpip2 2.031349 down 0.004550 1457233_at DnaJ (Hsp40) homolog, subfamily A, member 2 Dnaja2 2.0311542 up 0.013057 1424259_at transmembrane protein 112 Tmem112 2.0305111 down 0.009148 1448214_at pyruvate dehydrogenase (lipoamide) beta /// similar to pyruvate dehydrogenase (lipoamide) beta LOC100044400 /// LO 2.029061 up 0.000335 1422743_at phosphorylase kinase alpha 1 Phka1 2.0282216 up 0.026491 1417203_at ethylmalonic encephalopathy 1 Ethe1 2.0273259 down 0.000769 1416012_at EH-domain containing 1 Ehd1 2.0271885 up 0.004070 1435784_at autophagy-related 9A (yeast) Atg9a 2.0268528 up 0.012365 1439478_at acyl-CoA thioesterase 2 Acot2 2.0267203 up 0.004183 1417010_at zinc finger protein 238 Zfp238 2.0265622 up 0.000370 1442240_at Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) Ctr9 2.0261858 up 0.021742 1428643_at mannoside acetylglucosaminyltransferase 5 Mgat5 2.0260277 up 0.003814 1423568_at proteasome (prosome, macropain) subunit, alpha type 7 Psma7 2.0249794 down 0.000023 1422065_at killer cell lectin-like receptor subfamily B member 1D Klrb1d 2.0249763 down 0.004078 1419301_at frizzled homolog 4 (Drosophila) Fzd4 2.0247924 up 0.002423 1436085_at zinc finger and BTB domain containing 34 Zbtb34 2.0247853 up 0.000599 1439230_at RIKEN cDNA 4922505E12 gene 4922505E12Rik 2.0243556 down 0.001250 1423960_at membrane bound O-acyltransferase domain containing 5 Mboat5 2.0237 up 0.000288 1453988_a_at insulin degrading enzyme Ide 2.0236986 down 0.008956 1420655_at patatin-like phospholipase domain containing 3 Pnpla3 2.023652 up 0.017327 1450056_at adenomatosis polyposis coli /// similar to adenomatosis polyposis coli Apc /// LOC10004886 2.023595 down 0.010063 1451584_at hepatitis A virus cellular receptor 2 Havcr2 2.0230005 down 0.000484 1429125_at zinc finger and BTB domain containing 9 Zbtb9 2.021459 up 0.004839 1424720_at mannoside acetylglucosaminyltransferase 4, isoenzyme B Mgat4b 2.021244 up 0.000056 1433810_x_at DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 Ddx5 2.0206916 up 0.000867 1457782_at talin 1 Tln1 2.0197434 down 0.022761 1429992_at spermatogenesis associated glutamate (E)-rich protein 4b Speer4b 2.0188658 down 0.006169 1426890_a_at RNA polymerase II associated protein 1 Rpap1 2.018775 up 0.002780 1431129_at ubiquitin specific peptidase 31 Usp31 2.018514 up 0.003694 1434087_at 5,10-methylenetetrahydrofolate reductase Mthfr 2.0177665 up 0.013031 1450763_x_at wingless-related MMTV integration site 3 Wnt3 2.0175693 down 0.000255 1429114_at SEC14 and spectrin domains 1 Sestd1 2.017487 down 0.010203 1451746_a_at autophagy-related 12 (yeast) Atg12 2.0174284 down 0.004370 1441449_at jumonji, AT rich interactive domain 1C (Rbp2 like) Jarid1c 2.017087 up 0.029626 1448768_at myelin oligodendrocyte glycoprotein Mog 2.0166633 down 0.000466 1425072_at S-phase kinase-associated protein 2 (p45) Skp2 2.0162764 up 0.015464 1450656_at guanine nucleotide binding protein, alpha 13 Gna13 2.0160892 down 0.000301 1421496_at N-acylsphingosine amidohydrolase 3-like Asah3l 2.0153434 down 0.005364 1416430_at catalase Cat 2.0144958 up 0.000017 1439408_a_at mediator complex subunit 1 Med1 2.014385 up 0.002064 1416542_at PHD finger protein 1 Phf1 2.0139859 up 0.001583 1417507_at cytochrome b-561 Cyb561 2.0138736 up 0.009676 1417969_at F-box protein 31 Fbxo31 2.013193 up 0.000179 1425210_s_at zinc finger protein 84 Zfp84 2.012765 up 0.024700 1441906_x_at Synapse associated protein 1 Syap1 2.0126164 up 0.029176 1452218_at coiled-coil domain containing 117 Ccdc117 2.0125022 up 0.000235 1420876_a_at septin 6 sept6 2.01147 down 0.000334 1441198_at zinc finger protein 39 Zfp39 2.0109599 up 0.020512 1428625_a_at RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) Rmi1 2.0108745 up 0.004899 1434138_at prune homolog (Drosophila) Prune 2.0104094 up 0.000105 1426594_at FERM domain containing 4B Frmd4b 2.010138 down 0.004108 1416553_at stimulated by retinoic acid 13 Stra13 2.00979 down 0.000015 1437023_at zinc finger protein 12 Zfp12 2.00962 up 0.008576 1435556_at zinc finger protein 597 Zfp597 2.0092666 up 0.003786 1455429_at expressed sequence AI450540 /// hypothetical protein LOC100044843 AI450540 /// LOC100 2.0080822 up 0.000778 1436726_s_at serine palmitoyltransferase, long chain base subunit 1 Sptlc1 2.0080278 up 0.001319 1446160_x_at transmembrane protein 69 Tmem69 2.0078254 up 0.006501 1438080_at mitochondrial ribosomal protein L11 Mrpl11 2.0077713 down 0.023304 1430851_at zinc finger protein 444 Zfp444 2.0075035 up 0.006695 1429124_s_at REX1, RNA exonuclease 1 homolog (S. cerevisiae) Rexo1 2.0072355 up 0.000039 1434236_at zinc finger, DHHC domain containing 20 Zdhhc20 2.0068667 up 0.029582 1416008_at special AT-rich sequence binding protein 1 Satb1 2.006819 up 0.002754 1450332_s_at flavin containing monooxygenase 5 /// similar to Flavin containing monooxygenase 5 Fmo5 /// LOC100046 2.0067222 up 0.024375 1440856_at mitogen activated protein kinase 8 Mapk8 2.0066173 up 0.000027 1449473_s_at CD40 antigen Cd40 2.0061579 down 0.011127 1438732_at hypothetical protein 6430511F03 6430511F03 2.006075 down 0.026016 1423900_at thyroid hormone receptor interactor 12 Trip12 2.005579 up 0.005267 1453586_at ectonucleoside triphosphate diphosphohydrolase 1 Entpd1 2.0053284 up 0.001777 1431058_at HIV TAT specific factor 1 Htatsf1 2.0052834 up 0.030829 1460632_at retinol dehydrogenase 10 (all-trans) Rdh10 2.0050666 up 0.009892 1416701_at Rho family GTPase 3 Rnd3 2.0048413 down 0.028235 1426733_at inositol 1,3,4-triphosphate 5/6 kinase Itpk1 2.0043929 up 0.000936 1420331_at C-type lectin domain family 4, member e Clec4e 2.0042763 down 0.021087 1444881_at TAO kinase 3 Taok3 2.0041583 up 0.022371 1437555_at BarH-like 2 (Drosophila) Barhl2 2.0040588 down 0.000198 1447786_at pleckstrin homology, Sec7 and coiled-coil domains 1 Pscd1 2.003518 down 0.004883 1440739_at vascular endothelial growth factor C Vegfc 2.003076 up 0.001359 1441318_at jumonji, AT rich interactive domain 1A (Rbp2 like) Jarid1a 2.0028796 up 0.024252 1455046_a_at pogo transposable element with ZNF domain Pogz 2.0025506 up 0.000601 1460720_at transient receptor potential cation channel, subfamily C, member 4 associated protein Trpc4ap 2.0025148 down 0.000399 1421215_a_at sarcolemma associated protein Slmap 2.0022044 down 0.000012 1453039_at zinc finger protein 335 Zfp335 2.0018048 up 0.000499 1440263_at neural regeneration protein Nrp 2.0016797 up 0.002579 1452217_at AHNAK nucleoprotein (desmoyokin) Ahnak 2.00155 down 0.000456 1418074_at ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransfeSt6galnac4 2.0014184 up 0.000230 1437477_at leucine rich repeat (in FLII) interacting protein 1 Lrrfip1 2.0009866 down 0.000185 1437337_x_at fucokinase Fuk 2.000798 up 0.001291 1460239_at tetraspanin 13 Tspan13 2.0000224 down 0.001162 Supplemental Table 2. Gene expression changes induced in Ly-6Chi monocytes by a PPARgamma agonist

Fold change Regulation regulated in P value [rosi] Probe Set ID Gene Title Gene Symbol [rosi] vs [rosi] vs Gr1lo vs [chow] [chow] [chow] 1451675_a_at aminolevulinic acid synthase 2, erythroid Alas2 44.302654 down YES 6.61E-04 1455966_s_at nudix (nucleoside diphosphate linked moiety X)-type motif 21 Nudt21 24.786081 up YES 9.05E-08 1453840_at poly A binding protein, cytoplasmic 1 Pabpc1 24.74167 up YES 3.83E-05 1440246_at longevity assurance homolog 6 (S. cerevisiae) Lass6 15.65066 up YES 7.15E-05 1459908_at CD47 antigen (Rh-related antigen, integrin-associated signal transducer) Cd47 14.328726 up YES 3.00E-05 1430997_at CD47 antigen (Rh-related antigen, integrin-associated signal transducer) Cd47 13.962246 up YES 6.46E-04 1417714_x_at hemoglobin alpha, adult chain 1 /// hemoglobin alpha, adult chain 2 Hba-a1 /// Hba-a2 13.9602995 down YES 2.64E-04 1456429_at mucosa associated lymphoid tissue lymphoma translocation gene 1 Malt1 10.642056 down YES 2.38E-04 1438216_at ras responsive element binding protein 1 Rreb1 7.0396495 up YES 2.90E-04 1437633_at ankyrin repeat domain 11 Ankrd11 6.1032662 down YES 6.25E-05 1458354_x_at keratin 28 Krt28 5.6936116 down YES 2.96E-04 1449666_at Attractin like 1 Atrnl1 5.373021 up no 9.19E-05 1450760_a_at inhibitor of growth family, member 3 Ing3 4.9261084 up YES 2.91E-04 1451285_at fusion, derived from t(12;16) malignant liposarcoma (human) Fus 4.9043264 up YES 3.48E-04 1417184_s_at hemoglobin, beta adult major chain /// hemoglobin, beta adult minor chain Hbb-b1 /// Hbb-b2 4.542306 down YES 1.68E-04 1459766_x_at Splicing factor 1 Sf1 4.4731736 down YES 1.33E-04 1417586_at timeless homolog (Drosophila) Timeless 4.358432 up no 6.88E-05 1419766_at SNF1-like kinase Snf1lk 4.230841 up YES 8.27E-06 1428361_x_at hemoglobin alpha, adult chain 1 /// hemoglobin alpha, adult chain 2 Hba-a1 /// Hba-a2 4.213538 down YES 5.23E-04 1428433_at homeodomain interacting protein kinase 2 Hipk2 4.1658225 up YES 4.57E-06 1423176_at transducer of ErbB-2.1 Tob1 3.8512118 up YES 5.21E-04 1452757_s_at hemoglobin alpha, adult chain 1 /// hemoglobin alpha, adult chain 2 Hba-a1 /// Hba-a2 3.8503463 down YES 1.45E-04 1428306_at DNA-damage-inducible transcript 4 Ddit4 3.8086388 up YES 5.48E-04 1450381_a_at B-cell leukemia/lymphoma 6 Bcl6 3.7346113 down YES 6.23E-05 1443867_at ankyrin repeat domain 12 Ankrd12 3.5581613 down YES 1.36E-04 1448710_at chemokine (C-X-C motif) receptor 4 Cxcr4 3.5181813 up YES 1.45E-04 1455191_x_at Phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha Pip5k1a 3.5067797 up YES 5.17E-04 1419568_at mitogen activated protein kinase 1 Mapk1 3.5025368 up YES 2.00E-04 1420132_s_at Pituitary tumor-transforming 1 interacting protein Pttg1ip 3.4977682 up no 4.44E-04 1416001_a_at coactosin-like 1 (Dictyostelium) Cotl1 3.496707 down YES 1.30E-04 1456565_s_at mitogen activated protein kinase kinase kinase 12 Map3k12 3.3181763 up YES 1.32E-05 1456288_at schlafen 5 Slfn5 3.2178566 up YES 9.12E-05 1423521_at lamin B1 Lmnb1 3.149376 up no 1.10E-04 1448278_at XPA binding protein 2 Xab2 3.145792 down YES 2.81E-04 1416002_x_at coactosin-like 1 (Dictyostelium) Cotl1 3.1412868 down YES 1.14E-04 1448405_a_at EP300 interacting inhibitor of differentiation 1 Eid1 3.1362472 up YES 5.52E-05 1420089_at Nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha Nfkbia 3.0740347 up YES 5.34E-06 1448452_at interferon regulatory factor 8 Irf8 3.0162983 down YES 4.93E-04 1434045_at cyclin-dependent kinase inhibitor 1B Cdkn1b 2.997941 up YES 6.32E-05 1460521_a_at oligonucleotide/oligosaccharide-binding fold containing 2A Obfc2a 2.9844854 down YES 4.09E-04 1424863_a_at homeodomain interacting protein kinase 2 Hipk2 2.9749186 up YES 1.36E-04 1434834_at suppressor of cytokine signaling 7 Socs7 2.936305 up YES 2.53E-04 1422805_a_at inhibitor of growth family, member 3 Ing3 2.9311638 up YES 1.41E-04 1426123_a_at ribosome binding protein 1 Rrbp1 2.9131417 up no 6.11E-04 1442256_at protein kinase C, delta Prkcd 2.861418 up YES 4.05E-04 1455979_at AT rich interactive domain 1B (Swi1 like) Arid1b 2.854379 up YES 3.77E-04 1419918_at transmembrane emp24 protein transport domain containing 7 Tmed7 2.8326201 up but down in Gr 4.66E-04 1416898_a_at interferon regulatory factor 3 Irf3 2.79863 down no 2.57E-04 1446928_at DnaJ (Hsp40) homolog, subfamily C, member 17 /// similar to DnaJ (Hsp40) homolog, Dnajc17 /// LOC621763 2.7832994 down YES 2.00E-04 1425675_s_at CEA-related cell adhesion molecule 1 Ceacam1 2.7573066 down YES 5.78E-04 1428848_a_at microtubule-actin crosslinking factor 1 Macf1 2.739819 down YES 2.63E-04 1433662_s_at tissue inhibitor of metalloproteinase 2 Timp2 2.7326562 down YES 3.83E-04 1456040_at splicing factor 3b, subunit 2 Sf3b2 2.7068357 down YES 2.79E-04 1424980_s_at anterior pharynx defective 1a homolog (C. elegans) /// similar to Aph1a protein Aph1a /// LOC100039623 2.665508 up YES 2.32E-04 1420038_at VATPase, H+ transporting, lysosomal V1 subunit E1 Atp6v1e1 2.6470764 up no 5.92E-04 1438089_a_at BCL2-associated transcription factor 1 Bclaf1 2.6401317 down YES 4.72E-05 1443904_at fatty acid desaturase domain family, member 6 Fads6 2.5871887 up no 4.84E-04 1425983_x_at homeodomain interacting protein kinase 2 Hipk2 2.5769396 up YES 1.55E-04 1447880_x_at Endothelial differentiation, sphingolipid G-protein-coupled receptor, 5 Edg5 2.5735555 up no 2.06E-04 1426169_a_at linker for activation of T cells family, member 2 Lat2 2.5679476 down YES 2.39E-05 1435912_at UBX domain containing 7 Ubxd7 2.5284595 up YES 5.70E-04 1426055_a_at phosphatidylinositol glycan anchor biosynthesis, class Q Pigq 2.5096223 down S but also up G 3.71E-04 1436959_x_at nasal embryonic LHRH factor Nelf 2.490652 up YES 2.93E-04 1423653_at ATPase, Na+/K+ transporting, alpha 1 polypeptide Atp1a1 2.4872677 down YES 1.05E-04 1433633_at interferon regulatory factor 2 binding protein 2 Irf2bp2 2.4721398 up YES 8.17E-05 1436297_a_at glutamate receptor, ionotropic, N-methyl D-asparate-associated protein 1 (glutamate bGrina 2.4569983 up YES 2.93E-04 1448357_at small nuclear ribonucleoprotein polypeptide G Snrpg 2.4399037 down YES 1.09E-04 1419655_at transducin-like enhancer of split 3, homolog of Drosophila E(spl) /// similar to mKIAA15LOC100048342 /// Tle3 2.4285178 up YES 6.11E-05 1420852_a_at UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 B3gnt2 2.4115765 down YES 4.71E-04 1436526_at N-acetylglucosamine-1-phosphotransferase, gamma subunit Gnptg 2.4114897 down YES 2.39E-04 1456352_a_at splicing factor 3b, subunit 2 Sf3b2 2.3976443 down YES 7.50E-05 1459861_s_at F-box and leucine-rich repeat protein 10 /// similar to F-box and leucine-rich repeat proFbxl10 /// LOC100039668 2.394692 up YES 6.67E-04 1449700_at Immunoglobulin (CD79A) binding protein 1 Igbp1 2.391 up no 7.24E-06 1435416_x_at phosphatidylinositol glycan anchor biosynthesis, class Q Pigq 2.3844087 up but also up Gr 1.13E-04 1429590_at transforming, acidic coiled-coil containing protein 1 Tacc1 2.382649 up no 4.95E-06 1423815_at DEAD (Asp-Glu-Ala-Asp) box polypeptide 56 Ddx56 2.3814497 down YES 3.77E-04 1421147_at telomeric repeat binding factor 2 Terf2 2.3800838 up YES 5.08E-05 1442763_s_at tubulin tyrosine ligase-like family, member 10 Ttll10 2.369847 down YES 1.45E-04 1427347_s_at tubulin, beta 2a Tubb2a 2.3581176 up no 2.09E-04 1450155_at integrin alpha 4 Itga4 2.3285463 down YES 6.12E-04 1450106_a_at Ena-vasodilator stimulated phosphoprotein /// similar to Ena-VASP-like Evl /// LOC100047333 2.3224318 down no 2.60E-04 1452187_at RNA binding motif protein 5 Rbm5 2.321138 down YES 3.31E-04 1450674_at cyclin-dependent kinase 5 Cdk5 2.296036 down no 2.86E-04 1459788_at G protein-coupled receptor 107 Gpr107 2.2847037 down YES 3.97E-05 1434128_a_at zinc finger protein 574 Zfp574 2.2833705 up YES 3.04E-04 1425711_a_at thymoma viral proto-oncogene 1 /// similar to serine/threonine protein kinase Akt1 /// LOC100047666 2.2825615 down YES 3.80E-04 1438625_s_at PCTAIRE-motif protein kinase 1 Pctk1 2.2818542 up YES 2.00E-05 1433805_at Janus kinase 1 Jak1 2.2816684 down YES 3.76E-05 1416028_a_at hematological and neurological expressed sequence 1 Hn1 2.2762318 down no 8.01E-05 1439787_at purinergic receptor P2X, ligand-gated ion channel, 7 P2rx7 2.2744448 up no 5.76E-05 1421122_at Casitas B-lineage lymphoma-like 1 Cbll1 2.2712693 up YES 1.09E-04 1452678_a_at cysteine conjugate-beta lyase 1 Ccbl1 2.26434 down YES 1.33E-04 1429708_at NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 11 Ndufa11 2.2626176 down no 9.76E-05 1419829_a_at Growth factor receptor bound protein 2-associated protein 2 Gab2 2.2498138 up YES 4.05E-04 1434314_s_at RAB11 family interacting protein 5 (class I) Rab11fip5 2.2281976 up YES 4.41E-04 1423090_x_at SEC61, gamma subunit /// similar to SEC61 gamma LOC100042561 /// LOC1000 2.2242992 down YES 1.93E-04 1451167_at coiled-coil domain containing 101 /// similar to coiled-coil domain containing 101 Ccdc101 /// LOC100047712 2.2197113 down YES 1.94E-04 1455308_at transmembrane protein 16F Tmem16f 2.203633 up YES 3.40E-04 1450350_a_at Jun dimerization protein 2 Jundm2 2.197676 up YES 4.09E-04 1422806_x_at inhibitor of growth family, member 3 Ing3 2.1859822 up YES 3.14E-04 1439938_at serine/threonine kinase 38 Stk38 2.179545 down YES 3.95E-05 1423255_at ATPase, H+ transporting, lysosomal V1 subunit G1 Atp6v1g1 2.1740487 down YES 1.04E-04 1434540_a_at clathrin, light polypeptide (Lca) Clta 2.173139 down YES 8.31E-05 1438951_x_at nucleoporin 54 /// hypothetical protein LOC100042745 /// hypothetical protein LOC100LOC100042745 /// LOC1000 2.1688108 up YES 6.61E-04 1449059_a_at 3-oxoacid CoA transferase 1 Oxct1 2.165503 up no 3.87E-04 1436306_at SAPS domain family, member 1 Saps1 2.1621811 down no 2.85E-04 1429246_a_at annexin A6 Anxa6 2.1593692 down YES 3.68E-04 1427670_a_at transcription factor 12 Tcf12 2.1551142 up no 1.96E-04 1415819_a_at protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform Ppp2r1a 2.1522155 down no 4.91E-06 1428733_at guanine nucleotide binding protein (G protein), gamma transducing activity polypeptideGngt2 2.148737 down no 1.99E-05 1460004_x_at syntaxin 6 Stx6 2.1468742 up YES 6.54E-04 1419975_at Sterol carrier protein 2, liver Scp2 2.1382716 up YES 3.77E-04 1427171_at rearranged L-myc fusion sequence Rlf 2.1346292 up no 4.78E-04 1430575_a_at tripeptidyl peptidase II Tpp2 2.129198 down YES 1.37E-04 1451036_at spastic paraplegia 21 homolog (human) /// similar to spastic paraplegia 21 homolog LOC100048562 /// Spg21 2.1279655 down YES 2.70E-05 1426948_at translocated promoter region Tpr 2.1277332 down YES 1.79E-04 1451333_a_at proacrosin binding protein Acrbp 2.1273022 down no 1.51E-04 1442004_at tripartite motif-containing 65 Trim65 2.1242676 up YES 2.26E-04 1418324_at feminization 1 homolog b (C. elegans) Fem1b 2.1217682 up no 3.49E-04 1434320_at general transcription factor IIIC, polypeptide 4 Gtf3c4 2.1203275 up YES 4.51E-04 1430326_s_at ubiquinol-cytochrome c reductase, complex III subunit VII Uqcrq 2.119957 down YES 1.68E-04 1451185_at splicing factor 3b, subunit 5 Sf3b5 2.1164172 down YES 4.59E-04 1449731_s_at nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha Nfkbia 2.1131935 up YES 4.14E-06 1418578_at diacylglycerol kinase, alpha Dgka 2.1108313 down no 6.82E-04 1440384_at transmembrane and coiled coil domains 1 Tmcc1 2.1097014 up YES 5.54E-04 1425937_a_at hexamethylene bis-acetamide inducible 1 Hexim1 2.1022327 up YES 3.72E-04 1449221_a_at ribosome binding protein 1 Rrbp1 2.1015573 up no 6.74E-05 1455752_a_at transmembrane protein 134 Tmem134 2.0875056 down no 4.26E-05 1415807_s_at splicing factor, arginine/serine-rich 2 (SC-35) Sfrs2 2.0846648 down YES 5.78E-04 1459783_s_at cappuccino Cno 2.082603 up YES 1.52E-04 1437436_s_at G protein-coupled receptor kinase 6 Grk6 2.0729542 up no 3.70E-05 1437526_x_at heterogeneous nuclear ribonucleoprotein R /// similar to Hnrpr protein Hnrpr /// LOC620521 2.0699444 up no 5.44E-04 1421083_x_at barrier to autointegration factor 1 Banf1 2.0582511 down YES 1.32E-04 1438115_a_at solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1 Slc9a3r1 2.0549178 up no 1.11E-04 1424053_a_at transcription factor 25 (basic helix-loop-helix) Tcf25 2.0545728 down no 6.80E-05 1429681_a_at glycoprotein, synaptic 2 Gpsn2 2.0381024 down no 1.21E-04 1419526_at Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog Fgr 2.0361915 down no 9.90E-06 1452833_at Rap guanine nucleotide exchange factor (GEF) 2 Rapgef2 2.0348969 up no 3.42E-04 1455110_at GA repeat binding protein, beta 2 Gabpb2 2.0321212 up no 2.67E-04 1416755_at DnaJ (Hsp40) homolog, subfamily B, member 1 Dnajb1 2.027196 up YES 9.56E-05 1452920_a_at peptidylprolyl isomerase (cyclophilin)-like 2 Ppil2 2.0073085 down no 1.32E-04 1429486_at 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 Pfkfb2 2.0066204 up no 4.04E-05 1436567_a_at NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B14.5a) Ndufa7 2.0053868 down no 9.82E-05 Supplemental Table 3. Downregulated genes in lung macrophages from LysM-cre x PPARgflox/flox mice.

ProbeSet Gene CTRL - mean normalized LysMcre x PPARfl/fl - mean SD SD fold T-test ID Symbol signal intensity normalized signal intensity 10490159 Pmepa1 774.6 17.1 100.6 15.4 7.696 0.0000247 10421387 Sftpc 352.0 96.9 50.9 0.5 6.921 0.0251327 10604743 Snord61 1347.9 206.0 284.0 106.8 4.747 0.0073758 10499130 Rnu73b 844.1 194.7 179.5 98.4 4.702 0.0229747 10576216 Rpl13 286.7 36.6 64.5 23.4 4.447 0.0050655 10497265 Fabp4 189.0 17.0 53.3 1.8 3.546 0.0017651 10514466 Jun 1352.2 72.1 386.1 75.8 3.503 0.0007205 10432897 Krt79 1491.6 102.3 426.5 36.2 3.497 0.0008695 10427035 Nr4a1 1203.9 216.9 360.5 0.5 3.339 0.0137005 10563110 Snord34 1761.0 40.6 546.7 25.1 3.221 0.0000442 10439651 Cd200 132.7 8.3 43.6 2.5 3.045 0.0007753 10523156 Cxcl2 792.7 167.3 262.3 188.7 3.023 0.0448428 10539433 Mobkl1b 648.7 73.6 220.4 96.5 2.944 0.0105667 10491191 Rpl22l1 303.4 25.2 104.6 15.1 2.901 0.0022959 10454782 Egr1 235.7 21.9 81.5 9.9 2.890 0.0028830 10357261 Marco 587.2 19.9 203.4 59.5 2.886 0.0015843 10450501 Tnf 733.7 67.7 254.7 63.4 2.881 0.0042048 10346328 Mars2 307.9 60.1 111.7 5.1 2.756 0.0221417 10468249 Cnnm2 143.8 34.0 52.7 17.4 2.731 0.0429344 10404053 Hist1h2bc 1382.1 321.0 506.8 217.5 2.727 0.0457774 10506571 Dhcr24 329.1 27.3 122.9 14.8 2.679 0.0025059 10366346 Phlda1 805.1 145.9 313.7 1.9 2.566 0.0202774 10397346 Fos 3795.6 177.6 1508.8 232.5 2.516 0.0010588 10552964 Ftl1 3901.2 224.6 1564.0 98.5 2.494 0.0009118 10433937 Ppm1f 564.0 93.9 227.9 90.8 2.475 0.0286873 10438769 Cldn1 281.5 36.0 114.3 3.9 2.463 0.0083932 10438909 Atp13a3 373.7 79.3 158.5 58.1 2.358 0.0480961 10595803 Rnf7 258.3 20.9 111.5 50.0 2.316 0.0172448 10532921 Sppl3 136.4 17.1 59.0 17.0 2.312 0.0156688 10369615 Srgn 2373.6 202.3 1028.2 335.1 2.309 0.0102294 10442098 Fpr3 135.6 19.0 59.4 7.3 2.282 0.0139004 10435075 Tfrc 182.4 41.7 80.6 2.2 2.264 0.0465390 10561474 Il28a 274.4 22.8 124.6 31.4 2.202 0.0080512 10403413 Idi1 431.6 60.2 196.7 34.5 2.194 0.0167156 10544687 Cycs 128.7 21.7 58.8 11.2 2.189 0.0267926 10449741 Sik1 291.7 34.9 134.7 35.6 2.165 0.0163283 10461452 Fen1 136.7 20.8 64.2 14.5 2.130 0.0246391 10544523 Rny1 1475.0 229.3 706.5 206.9 2.088 0.0322302 10495054 Rhoc 674.5 76.9 325.0 65.8 2.076 0.0136988 10448737 Ndufb10 228.7 28.1 113.1 2.5 2.022 0.0117387 10567297 Itpripl2 1950.8 80.0 969.2 291.7 2.013 0.0094775 10545192 Rprl1 349.5 69.9 173.8 3.1 2.010 0.0434545 10401958 Naca 2325.4 214.7 1163.3 101.6 1.999 0.0062695 10420730 Fdft1 328.3 35.8 164.3 14.0 1.998 0.0096207 10377537 Chd3 125.8 17.7 63.0 12.6 1.997 0.0239158 10509163 Id3 122.6 13.3 61.5 9.6 1.995 0.0119861 10424349 Sqle 275.6 21.6 139.8 12.5 1.971 0.0043827 10417798 Kcnk5 125.6 18.2 63.7 8.3 1.971 0.0226558 10458382 Cd14 988.9 43.6 502.7 113.2 1.967 0.0056178 10399360 Rhob 857.0 117.0 438.6 43.7 1.954 0.0188840 10490826 Zbtb10 123.9 4.0 63.7 14.2 1.944 0.0049485 10541494 Rps27a 2536.5 116.5 1317.6 316.6 1.925 0.0074594 10348864 Thap4 131.9 22.1 69.0 12.0 1.911 0.0376177 10576795 Cd209a 1326.5 234.1 699.1 31.1 1.897 0.0372748 10449657 Tff3 161.6 21.5 85.5 5.4 1.890 0.0185448 10373912 Osm 319.4 48.2 169.3 7.3 1.886 0.0253914 10518350 Hmgb2 608.2 56.6 323.3 18.2 1.881 0.0071195 10522973 Utp3 242.1 29.1 129.2 25.8 1.873 0.0217299 10583732 Ldlr 556.7 49.9 297.6 6.1 1.871 0.0061449 10495042 Ppm1j 146.8 6.3 79.1 0.9 1.857 0.0007171 10572456 Jund 1008.4 154.9 546.2 151.1 1.846 0.0458924 10363735 Egr2 1422.2 89.5 772.9 43.7 1.840 0.0027161 10529480 Acox3 120.2 8.7 65.7 13.0 1.831 0.0101517 10456357 Pmaip1 164.8 4.6 90.0 9.6 1.830 0.0011724 10368970 Prdm1 389.8 61.1 213.1 22.6 1.829 0.0330748 10414548 Rnase6 1055.2 101.3 577.1 141.2 1.828 0.0203619 10491058 Rprl2 895.3 101.3 492.1 22.0 1.819 0.0132618 10454445 Slc25a46 128.0 10.6 70.6 14.1 1.814 0.0131557 10479362 Rps21 1014.5 133.1 562.0 87.0 1.805 0.0256010 10580183 Ier2 622.4 91.0 345.0 21.8 1.804 0.0274353 10353991 Rpl12 2816.5 37.8 1570.6 301.6 1.793 0.0045241 10369154 Man1a 135.5 7.0 75.6 2.0 1.793 0.0015111 10453049 Cdc42ep3 1825.1 181.3 1021.2 299.7 1.787 0.0305752 10495781 Bcar3 1807.5 78.3 1015.9 78.7 1.779 0.0015860 10488378 Thbd 722.7 103.8 407.0 28.3 1.775 0.0278908 10562044 Zbtb32 152.0 12.8 85.7 11.5 1.774 0.0098000 10409031 Dek 659.9 50.9 372.4 4.4 1.772 0.0047868 10448557 Abca3 232.3 32.1 131.4 30.3 1.768 0.0393045 10361104 Ppp2r5a 1986.8 147.1 1126.2 170.5 1.764 0.0089713 10538970 Krcc1 385.3 13.3 220.5 24.4 1.747 0.0020498 10397002 Sipa1l1 176.6 9.1 101.4 7.7 1.742 0.0024687 10411454 Sec61b 421.8 48.0 244.0 27.3 1.728 0.0191953 10420171 Adcy4 125.6 13.1 72.9 1.7 1.724 0.0125478 10525677 Hip1r 200.4 10.0 116.9 17.8 1.715 0.0061117 10532628 Myo18b 202.5 18.1 118.2 38.2 1.713 0.0402869 10399588 Zfp125 742.6 91.4 433.5 72.3 1.713 0.0287568 10533720 Niacr1 699.5 54.6 410.0 119.4 1.706 0.0306624 10367775 Stxbp5 145.9 6.9 85.8 33.1 1.699 0.0455377 10572800 Klf2 295.3 7.1 174.1 12.3 1.697 0.0007071 10425283 Maff 339.1 42.4 199.9 27.5 1.697 0.0278927 10499483 Fdps 235.5 10.3 138.9 8.3 1.696 0.0016274 10551021 Rps19 481.1 72.0 284.0 35.2 1.694 0.0403529 10466008 Dak 225.6 30.6 133.7 4.8 1.688 0.0279608 10406250 Rpl37a 2365.5 346.8 1405.6 159.7 1.683 0.0386014 10544971 Lsm5 161.1 23.8 95.9 1.7 1.680 0.0348520 10520942 Plb1 194.3 13.4 116.2 0.1 1.672 0.0043550 10559513 Cab39 187.9 1.7 112.5 14.3 1.671 0.0021988 10416004 Zfp395 175.0 14.3 105.0 21.4 1.667 0.0202760 10527920 Cyp51 242.6 28.4 146.2 19.7 1.659 0.0263765 10413174 Rps24 1762.5 185.4 1064.9 144.2 1.655 0.0214504 10527448 Bud31 214.6 14.7 129.7 15.6 1.655 0.0084357 10432006 Hdac7 120.7 7.6 73.0 5.2 1.654 0.0048338 10365714 Sec61g 539.2 38.6 326.0 13.2 1.654 0.0055080 10424097 Med30 126.3 19.5 76.4 2.8 1.653 0.0418950 10444407 Ager 185.9 16.5 112.5 11.1 1.652 0.0124766 10587690 Bcl2a1b 2564.1 297.3 1555.6 13.4 1.648 0.0198975 10591781 Anln 570.3 40.3 346.5 11.2 1.646 0.0052831 10591806 rp9 396.3 54.5 241.4 3.2 1.642 0.0316953 10497644 Sec62 347.1 34.2 211.7 49.9 1.640 0.0343928 10526215 Rps28 1923.5 255.0 1173.4 155.1 1.639 0.0361225 10602716 Ubqln2 242.4 13.8 147.9 4.8 1.638 0.0029533 10506118 Usp1 387.5 35.0 237.1 9.8 1.634 0.0109699 10518361 Smarca5 879.6 99.4 538.8 43.0 1.633 0.0217897 10540072 Ppp1r2 410.7 29.2 252.1 65.4 1.629 0.0301480 10571739 Cdkn2aip 142.6 6.5 87.7 28.5 1.626 0.0400004 10515028 Zfyve9 123.6 3.6 76.3 4.3 1.620 0.0008707 10493003 Etv3l 141.9 14.6 87.8 7.6 1.617 0.0185070 10346960 Ccnyl1 178.9 14.0 110.7 6.9 1.617 0.0084795 10370999 Lingo3 213.8 6.7 132.4 36.9 1.615 0.0269459 10362201 Ctgf 136.1 5.7 84.6 21.5 1.610 0.0236950 10518855 Klhl21 121.3 7.1 75.5 7.7 1.607 0.0063313 10412844 Top2b 731.9 41.1 457.5 13.7 1.600 0.0031871 10587637 Tbx18 239.7 15.2 149.9 13.8 1.599 0.0068397 10591997 Adamts8 275.6 24.8 172.4 28.5 1.599 0.0226582 10528721 Galnt11 586.2 28.8 366.7 77.8 1.599 0.0177678 10441161 Hmgn1 304.6 12.8 192.0 7.8 1.587 0.0016942 10484371 Calcrl 575.2 27.5 362.9 14.1 1.585 0.0022999 10391242 Rab5c 1846.4 135.2 1165.6 198.9 1.584 0.0184110 10519207 Ccnl2 139.9 6.1 88.5 17.5 1.581 0.0153878 10548385 Olr1 2771.9 257.2 1753.9 299.4 1.580 0.0262480 10353032 Rpa3 165.2 9.2 104.6 12.1 1.579 0.0074765 10501020 Chi3l3 10175.5 646.9 6451.2 423.2 1.577 0.0059612 10365749 Lta4h 760.2 85.9 482.6 71.2 1.575 0.0333425 10403352 Klf6 2258.7 258.7 1436.6 144.4 1.572 0.0286562 10368947 Aim1 840.0 35.0 534.5 43.0 1.571 0.0030476 10397741 Psmc1 555.3 40.6 353.6 47.5 1.570 0.0143013 10510950 Hes5 180.5 8.8 115.1 24.1 1.568 0.0196833 10360720 Wdr26 1193.8 13.2 761.4 48.6 1.568 0.0005544 10385761 Ube2b 603.0 77.9 387.0 28.4 1.558 0.0366661 10484733 Olfr1174 334.0 34.5 214.5 27.5 1.558 0.0270938 10578123 Rbpms 433.7 23.6 278.8 36.1 1.555 0.0093867 10565958 P2ry6 1035.9 71.1 667.4 33.8 1.552 0.0071085 10354732 Hspd1 633.7 15.5 409.0 55.6 1.549 0.0056857 10504730 Anp32b 1259.8 29.9 813.8 24.6 1.548 0.0004223 10578916 Sc4mol 1623.7 103.3 1054.7 192.6 1.540 0.0209158 10600205 Dusp9 181.0 13.9 117.9 13.2 1.535 0.0149464 10403706 Psma2 685.4 72.4 447.2 49.9 1.533 0.0286437 10487597 Il1b 428.7 29.7 280.2 15.3 1.530 0.0080898 10576639 Nrp1 876.5 7.5 573.0 48.2 1.530 0.0013502 10394186 Dtnb 206.8 11.2 135.3 6.0 1.528 0.0040734 10358038 Rnpep 1531.4 92.0 1007.0 94.2 1.521 0.0084808 10606876 Morf4l2 647.2 70.7 425.8 33.9 1.520 0.0283915 10451004 Cd2ap 933.7 84.8 614.9 40.9 1.518 0.0174606 10528268 Ptpn12 3144.1 105.7 2071.5 28.0 1.518 0.0009034 10476886 Sstr4 155.5 20.2 102.5 10.6 1.517 0.0459104 10410124 Ctsl 2023.4 40.4 1336.0 106.3 1.515 0.0016952 10427461 Ptger4 362.2 25.5 239.2 48.8 1.514 0.0310131 10363983 Bcr 143.8 4.1 95.0 23.7 1.513 0.0323994 10475405 Eif3j 899.1 101.6 594.9 12.8 1.511 0.0279635 10452047 Ptprs 167.7 10.9 111.0 12.3 1.511 0.0120235 10371400 Cry1 253.9 1.3 168.3 0.4 1.508 0.0000032 10595633 Bcl2a1d 2492.3 341.8 1652.8 14.2 1.508 0.0459291 10435654 Lrrc58 1104.6 108.4 733.1 22.0 1.507 0.0198794 10498992 Tlr2 3481.9 270.6 2311.9 111.2 1.506 0.0114213 10359097 Tor1aip1 518.9 28.6 344.9 32.9 1.505 0.0079711 10527306 Lmtk2 137.7 8.6 92.0 8.5 1.497 0.0100962 10532157 Tmed5 695.7 59.2 464.9 14.5 1.497 0.0141799 10408113 Hist1h4i 183.3 16.0 123.0 18.0 1.490 0.0288362 10574259 Gpr56 149.6 8.2 100.4 10.1 1.489 0.0089582 10412466 Hmgcs1 739.3 26.6 496.9 84.8 1.488 0.0157694 10532164 Atp5k 555.5 71.3 373.6 23.3 1.487 0.0445603 10409645 Ubqln1 1064.1 48.3 715.6 47.3 1.487 0.0041371 10391254 Kcnh4 194.3 16.3 130.8 9.2 1.486 0.0166815 10459730 Me2 1081.4 31.2 728.0 77.6 1.485 0.0048996 10607403 Kctd12b 617.2 46.2 415.5 49.3 1.485 0.0185018 10507040 Spata6 353.7 34.1 238.5 3.2 1.483 0.0202629 10606436 Nsbp1 148.7 17.0 100.3 15.4 1.482 0.0488392 10402473 Clmn 557.7 47.4 376.3 17.5 1.482 0.0156699 10599377 Stag2 763.8 44.2 515.3 75.0 1.482 0.0169199 10606939 Rps4x 2974.1 94.7 2009.5 119.4 1.480 0.0020066 10603627 Bcor 223.7 18.7 151.4 3.0 1.478 0.0141312 10424607 Ptp4a3 160.9 6.3 108.9 12.5 1.477 0.0076363 10576873 Elavl1 1125.1 102.0 761.7 100.7 1.477 0.0295785 10423599 Matn2 1031.5 130.2 699.2 58.5 1.475 0.0470557 10432640 Bin2 1384.1 62.4 939.1 125.9 1.474 0.0118828 10510142 Vmn2r-ps14 1006.2 56.2 683.0 98.9 1.473 0.0169004 10574436 Khdrbs1 792.4 24.9 538.0 30.7 1.473 0.0019255 10427895 Basp1 159.8 9.5 108.6 9.1 1.471 0.0093373 10594774 Ccnb2 384.2 26.4 261.3 12.5 1.470 0.0095855 10438690 Rfc4 199.7 18.4 136.0 1.5 1.469 0.0187751 10391178 Dnajc7 946.2 15.3 644.7 92.0 1.468 0.0090347 10481259 Col5a1 167.1 14.0 113.9 5.4 1.467 0.0162239 10482929 Ly75 2719.4 178.2 1854.2 366.1 1.467 0.0344355 10594750 Fam148a 256.4 16.8 174.8 27.4 1.467 0.0236790 10368380 L3mbtl3 259.0 19.8 176.8 19.2 1.465 0.0194047 10588154 Stag1 759.8 47.2 518.8 59.1 1.464 0.0143655 10408487 Uqcrfs1 440.8 32.9 301.2 53.2 1.464 0.0332236 10388732 Dhrs13 169.6 6.2 115.9 12.3 1.463 0.0066119 10468046 Lbx1 133.6 15.9 91.4 2.0 1.462 0.0382489 10594988 Mapk6 1397.0 24.9 956.8 139.1 1.460 0.0100983 10582843 Itgb1 264.8 20.8 181.6 30.3 1.459 0.0333505 10374426 Pno1 227.1 23.9 156.0 20.4 1.456 0.0419026 10399198 Ncoa4 4075.1 139.3 2801.4 560.3 1.455 0.0267811 10563641 Rap1a 907.9 87.7 624.3 107.7 1.454 0.0465976 10402179 Smek1 583.2 48.2 401.7 7.3 1.452 0.0152069 10426760 Aqp2 129.3 7.5 89.1 19.9 1.451 0.0429256 10466000 Tmem138 458.2 31.4 315.7 9.0 1.451 0.0094358 10376513 Nlrp3 551.3 49.8 381.2 0.5 1.446 0.0194507 10411287 Btf3l4 686.9 31.3 475.1 3.8 1.446 0.0028577 10385034 Rpsa 1165.8 113.5 807.9 118.1 1.443 0.0422249 10407420 Net1 1631.3 82.1 1132.0 149.8 1.441 0.0154137 10364009 Bcr 376.9 17.8 261.5 41.9 1.441 0.0207597 10517559 Cdc42 4489.5 437.1 3117.8 80.0 1.440 0.0250115 10558242 Hmx2 175.4 15.0 121.8 4.6 1.440 0.0184021 10471978 Epc2 323.7 7.7 225.0 49.5 1.439 0.0343530 10568480 Nsmce4a 419.0 19.7 291.6 35.6 1.437 0.0128123 10555695 Rrm1 729.4 30.2 508.0 15.8 1.436 0.0026996 10532330 Ankle2 238.5 28.6 166.2 14.6 1.435 0.0497985 10554061 Adamts17 244.8 19.4 170.7 4.3 1.434 0.0148492 10542520 Atp5h 823.3 81.8 574.3 85.5 1.434 0.0462018 10431732 Zcrb1 767.1 49.6 535.1 3.6 1.434 0.0081794 10582862 Arhgef12 240.5 15.3 168.0 0.8 1.431 0.0079008 10489127 Rbl1 800.1 23.3 559.1 10.3 1.431 0.0009350 10584975 Sidt2 145.9 11.7 102.0 15.0 1.430 0.0338144 10462822 Exoc6 402.3 20.3 281.3 1.4 1.430 0.0040995 10408210 Hist1h2bc 1125.2 26.8 786.8 147.2 1.430 0.0242649 10402353 Ifi27l2b 135.0 12.6 94.4 4.9 1.429 0.0252796 10380381 Tob1 1692.1 144.1 1184.5 192.9 1.428 0.0414654 10487945 Prei4 3502.6 380.9 2452.8 311.3 1.428 0.0492727 10495773 Dnttip2 299.8 19.2 210.1 19.3 1.427 0.0144631 10584435 Vwa5a 1121.8 84.2 786.6 44.2 1.426 0.0153343 10394770 Odc1 583.8 53.4 409.4 24.8 1.426 0.0252173 10465604 Stip1 593.3 24.5 416.1 62.1 1.426 0.0178902 10367673 Plekhg1 680.2 72.3 477.6 62.7 1.424 0.0491486 10437945 Mcm4 441.3 21.0 309.9 20.7 1.424 0.0062619 10422598 Sepp1 1042.1 98.1 732.0 77.0 1.424 0.0341057 10512136 Bag1 497.2 25.9 349.4 36.6 1.423 0.0123395 10408812 Mak 448.2 31.0 315.1 20.8 1.422 0.0137483 10468070 Fgf8 217.5 12.7 153.0 25.7 1.422 0.0297377 10578615 Ing2 165.1 15.3 116.2 7.4 1.421 0.0268934 10600688 Map3k7ip3 370.7 17.0 261.1 27.8 1.420 0.0109188 10515253 Uqcrh 1119.9 121.2 789.3 68.6 1.419 0.0425397 10606581 Rps12 3264.9 241.5 2306.0 425.1 1.416 0.0444975 10508217 Sfpq 1516.8 157.5 1071.7 86.0 1.415 0.0384661 10375980 Aff4 1005.6 75.8 711.0 106.5 1.414 0.0343585 10354472 Gls 1286.4 86.5 910.4 15.3 1.413 0.0102621 10419151 Ear1 5842.2 265.8 4140.4 580.3 1.411 0.0185356 10503134 Sdcbp 3999.0 187.8 2839.3 469.0 1.408 0.0265543 10357454 Dars 674.6 75.3 479.0 1.0 1.408 0.0399968 10395538 Pnpla8 1453.5 123.3 1032.4 101.7 1.408 0.0287966 10468828 Eif3a 2508.6 178.7 1782.1 91.0 1.408 0.0143215 10600148 DXBay18 180.8 14.9 128.5 5.9 1.408 0.0201221 10416653 Kbtbd7 142.6 4.2 101.4 11.3 1.407 0.0087394 10463625 Fbxl15 172.1 13.7 122.4 17.6 1.406 0.0366840 10514255 Mllt3 147.8 3.3 105.2 10.6 1.405 0.0060636 10463803 Slk 1137.6 96.1 810.1 110.2 1.404 0.0380286 10510910 Prdm16 228.5 4.7 162.7 35.7 1.404 0.0414445 10431147 Ldoc1l 139.0 4.2 99.0 2.6 1.404 0.0013057 10400137 Dnajb9 780.1 38.1 555.6 80.1 1.404 0.0216224 10444802 H2-Q2 178.1 13.2 127.4 0.3 1.398 0.0140480 10453900 Riok3 1169.0 138.8 836.8 11.7 1.397 0.0491206 10487175 Cops2 679.7 79.7 486.8 4.3 1.396 0.0477669 10391036 Krt19 2865.5 20.9 2052.7 375.8 1.396 0.0264045 10521555 Lyar 196.4 7.9 140.8 17.0 1.395 0.0138482 10502778 Lphn2 398.9 37.1 286.2 15.5 1.394 0.0297086 10472605 Ssb 955.8 91.7 686.3 33.0 1.393 0.0315669 10383055 Cbx2 124.2 4.7 89.2 6.4 1.392 0.0055021 10554370 Zfp710 565.5 26.5 406.3 51.4 1.392 0.0176798 10411595 Naip2 1089.4 23.7 782.8 3.6 1.392 0.0004255 10447602 Ezr 2479.6 82.0 1782.7 298.4 1.391 0.0257429 10380419 Col1a1 123.7 10.8 89.0 5.2 1.389 0.0265518 10427814 Golph3 484.6 20.1 349.0 29.4 1.388 0.0081528 10566966 Eif4g2 3736.9 113.9 2695.0 222.8 1.387 0.0055445 10413304 Arf4 2602.8 159.4 1877.9 343.6 1.386 0.0441571 10563659 Spty2d1 449.7 42.6 324.6 28.9 1.385 0.0379664 10378059 Txndc17 1546.9 146.4 1118.5 89.5 1.383 0.0366806 10440560 Rnf160 321.7 11.2 232.7 35.4 1.382 0.0224617 10426751 Tmbim6 5331.0 23.7 3859.5 114.1 1.381 0.0001692 10568859 Ndufab1 388.7 40.6 281.4 21.2 1.381 0.0449344 10595831 Zbtb38 191.0 6.6 138.3 23.0 1.381 0.0274306 10374564 Cct4 1404.9 104.8 1018.2 31.1 1.380 0.0167701 10435661 Gpr156 121.8 12.5 88.4 1.5 1.378 0.0375476 10354389 Slc39a10 893.8 40.8 648.6 76.7 1.378 0.0167200 10554839 Picalm 3619.5 264.2 2626.7 409.1 1.378 0.0424654 10414113 Wapal 609.4 29.1 442.4 42.6 1.377 0.0127988 10380566 Phospho1 166.8 8.7 121.1 12.8 1.377 0.0164483 10569890 Aida 821.0 57.1 596.6 51.3 1.376 0.0211287 10537882 Cul1 925.1 54.7 672.4 31.5 1.376 0.0104808 10412082 Gpbp1 549.6 42.4 399.4 10.7 1.376 0.0184767 10472820 Itga6 259.6 15.6 188.8 26.6 1.375 0.0301273 10578683 Eif2s2 380.8 19.8 277.5 37.0 1.372 0.0243455 10524969 Hrk 213.8 13.6 155.9 15.7 1.372 0.0212284 10558903 Taldo1 1377.2 32.7 1004.3 103.3 1.371 0.0082514 10402715 Bag5 195.6 14.0 142.8 23.5 1.370 0.0469868 10407316 Pelo 165.4 1.7 120.9 20.8 1.368 0.0276234 10502537 Sh3glb1 2082.9 120.6 1523.7 173.9 1.367 0.0223546 10566571 Gvin1 434.1 27.8 317.7 33.2 1.366 0.0233583 10542557 Aebp2 491.8 29.1 360.3 32.5 1.365 0.0175731 10476759 Rin2 726.7 69.4 532.4 10.9 1.365 0.0335406 10453600 Cul2 497.8 13.9 364.9 0.2 1.364 0.0010280 10542395 Atf7ip 407.8 26.8 298.9 18.2 1.364 0.0161448 10364375 Cstb 778.4 60.0 570.7 10.2 1.364 0.0191546 10421908 Rps3a 3270.1 261.6 2398.6 45.9 1.363 0.0212940 10445898 Rab5a 1036.2 16.3 760.3 117.8 1.363 0.0222608 10474379 Hadhb 1624.4 144.5 1192.2 112.4 1.362 0.0390716 10439249 Parp14 398.1 10.0 292.3 2.3 1.362 0.0007939 10459927 Kcng2 142.5 11.3 104.9 8.7 1.359 0.0294736 10496621 Gtf2b 723.1 31.1 532.4 26.4 1.358 0.0058634 10488237 Snx5 1387.5 71.8 1021.7 10.5 1.358 0.0065108 10580885 Csnk2a2 782.0 54.5 576.3 1.8 1.357 0.0149058 10377603 Tmem102 152.4 7.2 112.4 3.6 1.355 0.0060006 10498800 Ube2d2 1244.9 74.3 918.6 2.6 1.355 0.0097554 10467230 Ide 645.0 29.5 476.3 2.9 1.354 0.0046532 10362520 Hdac2 535.2 11.4 395.3 20.4 1.354 0.0020047 10490053 Zfp217 481.8 22.5 355.9 10.6 1.354 0.0056913 10548105 Ccnd2 2223.1 141.6 1642.7 166.2 1.353 0.0241392 10599192 Lonrf3 597.8 47.1 441.7 20.4 1.353 0.0239185 10423134 Zfr 882.9 53.5 653.3 52.7 1.352 0.0179721 10521966 Papd4 1138.3 42.5 842.6 41.0 1.351 0.0045287 10490602 Eef1a2 133.2 6.3 98.7 4.1 1.350 0.0067601 10389526 Cltc 3446.2 151.6 2552.4 183.0 1.350 0.0091966 10562204 Fxyd7 151.7 9.5 112.6 2.5 1.347 0.0123006 10537343 Atp6v0a4 218.6 14.4 162.5 13.1 1.346 0.0218077 10601854 Wbp5 134.4 7.8 99.9 3.7 1.346 0.0111874 10363281 Ranbp2 822.6 59.0 611.9 25.5 1.344 0.0194860 10466075 Tmem132a 188.7 14.9 140.4 14.9 1.344 0.0382301 10379836 Mrm1 142.7 2.6 106.2 2.1 1.344 0.0005248 10360745 Lbr 245.2 23.8 182.5 8.2 1.344 0.0412719 10457273 Kif5b 778.5 24.9 579.4 30.9 1.344 0.0039968 10579600 Jak3 123.7 9.5 92.2 6.8 1.341 0.0284428 10392904 Ush1g 120.1 5.3 89.6 2.7 1.341 0.0053740 10584883 Fxyd6 200.6 7.4 149.6 15.4 1.341 0.0138325 10417147 Tm9sf2 1556.3 100.3 1160.7 181.8 1.341 0.0472687 10426767 Aqp5 129.7 9.1 96.8 1.1 1.341 0.0166113 10383953 Emid1 132.1 3.2 98.6 1.6 1.340 0.0009127 10469732 Yme1l1 1397.0 110.7 1043.0 113.3 1.339 0.0401836 10404702 Gcnt2 1106.2 68.8 825.9 87.8 1.339 0.0269902 10459288 Adrb2 1900.1 189.1 1419.0 29.1 1.339 0.0427038 10567020 Rpl7a 2672.1 82.3 1996.2 120.4 1.339 0.0046242 10574096 Ap3s1 1235.1 66.5 923.0 101.2 1.338 0.0233418 10542445 Strap 640.2 7.2 478.5 0.7 1.338 0.0000823 10350630 Fam129a 3024.0 137.8 2263.1 78.3 1.336 0.0063057 10538318 Tax1bp1 1312.5 90.2 982.8 41.1 1.335 0.0185571 10408882 Ranbp9 587.1 16.8 440.0 33.8 1.335 0.0065923 10589030 Qrich1 722.2 27.9 541.6 9.5 1.334 0.0034869 10458569 Nr3c1 772.3 18.6 579.8 24.4 1.332 0.0020269 10460626 Rnaseh2c 230.8 13.1 173.3 0.8 1.331 0.0097971 10399908 Prkar2b 2117.5 62.5 1590.6 149.4 1.331 0.0103987 10416355 Rcbtb2 619.5 41.2 465.5 31.6 1.331 0.0216572 10437222 Hnrnpa3 2693.1 141.6 2024.0 145.3 1.331 0.0143311 10556583 Nucb2 906.9 49.1 682.5 95.9 1.329 0.0368569 10547436 Wnk1 1063.1 70.7 800.3 47.7 1.328 0.0205009 10410207 Cbx3 189.5 17.1 142.7 4.9 1.327 0.0370071 10483679 Gpr155 1297.2 59.2 977.4 84.8 1.327 0.0146162 10388337 Pafah1b1 597.7 34.3 451.4 21.4 1.324 0.0135430 10356020 Dock10 2248.9 222.5 1699.2 21.7 1.324 0.0454913 10533945 Ubc 9986.1 633.9 7546.6 620.7 1.323 0.0239475 10534420 Vps37d 229.1 11.6 173.2 15.3 1.323 0.0178395 10580219 Calr 4416.1 242.8 3337.8 432.5 1.323 0.0341543 10358224 Ptprc 3941.8 227.5 2980.9 93.0 1.322 0.0121696 10604199 Cul4b 402.6 10.4 304.9 10.4 1.321 0.0019578 10568553 Chst15 238.3 10.8 180.4 24.8 1.321 0.0325966 10605349 Ube2d3 5553.5 381.7 4205.4 195.1 1.321 0.0210364 10482030 Stom 2202.0 134.7 1667.9 171.4 1.320 0.0288751 10529873 Rab2a 1769.3 70.5 1341.7 6.3 1.319 0.0039124 10559983 Zscan4-ps2 220.4 19.5 167.2 12.3 1.318 0.0442146 10435676 Gsk3b 701.9 19.9 532.9 30.5 1.317 0.0045085 10413670 Pbrm1 644.5 36.8 490.0 10.2 1.315 0.0116645 10386824 Akap10 456.9 4.6 347.4 34.1 1.315 0.0093464 10448094 Lnpep 1977.9 136.0 1505.1 77.1 1.314 0.0227442 10522009 Pgm1 308.3 22.4 234.7 22.7 1.314 0.0369772 10575328 Phlpp2 189.8 12.3 144.5 13.6 1.313 0.0302194 10505888 Ifna5 122.8 11.1 93.7 4.0 1.312 0.0417053 10512626 Olfr71 124.1 6.4 94.6 11.7 1.312 0.0323492 10503184 Chd7 529.1 45.0 403.8 5.8 1.310 0.0337492 10574962 Nfatc3 584.0 36.3 446.0 30.5 1.309 0.0219809 10368356 Akap7 355.2 9.1 271.4 38.9 1.309 0.0303006 10477572 Chmp4b 2509.2 103.0 1918.0 42.3 1.308 0.0051090 10603011 Rbbp7 619.2 28.2 473.4 61.4 1.308 0.0325673 10572109 Ints10 264.0 9.2 202.0 5.7 1.307 0.0036942 10432540 Lima1 1854.0 49.9 1419.0 74.4 1.307 0.0040035 10348471 Mlph 141.7 8.9 108.5 6.6 1.306 0.0215619 10520952 Ppp1cb 1298.8 49.6 995.0 50.1 1.305 0.0068068 10357436 Mcm6 545.8 27.0 418.1 36.9 1.305 0.0197517 10350535 Tpr 955.3 84.6 732.7 19.1 1.304 0.0398853 10589420 Cdc25a 332.2 28.4 254.8 19.5 1.304 0.0462123 10427214 Sp1 499.9 33.8 383.7 4.3 1.303 0.0194103 10545672 Mthfd2 172.0 9.4 132.0 18.5 1.303 0.0447240 10492205 Eif2a 777.4 46.1 597.1 10.9 1.302 0.0140312 10585840 Cd276 394.8 27.5 303.4 26.7 1.301 0.0348862 10567702 Arhgap17 568.7 43.7 437.3 7.8 1.301 0.0279788 10428763 Atad2 382.5 30.2 294.3 6.7 1.300 0.0304312 10407907 Rala 486.4 43.4 374.2 1.9 1.300 0.0404939 10578377 Frg1 447.7 31.6 344.6 37.5 1.299 0.0439066 10540897 Pparg 1726.5 151.4 1329.1 29.0 1.299 0.0397941 10530225 Pds5a 1148.3 101.1 884.0 44.3 1.299 0.0440619 10580331 Vps35 1522.2 51.3 1171.9 106.9 1.299 0.0142364 10500899 Fam19a3 136.6 5.6 105.2 6.2 1.299 0.0095542 10439985 Rg9mtd1 196.7 7.6 151.5 5.5 1.298 0.0057329 10428398 Eif3e 1068.8 26.8 824.3 57.9 1.297 0.0067735 10517240 Grrp1 124.7 8.8 96.3 4.4 1.295 0.0262087 10508089 Mrps15 1288.0 109.9 994.4 25.2 1.295 0.0384084 10589938 Gpd1l 159.5 5.5 123.2 1.1 1.295 0.0031786 10596988 Plxnb1 136.4 6.2 105.4 10.0 1.294 0.0213375 10385484 Ddx5 3084.8 173.0 2383.5 185.4 1.294 0.0226495 10441330 Zfp295 269.5 6.4 208.4 29.8 1.293 0.0336755 10443589 Zfand3 762.7 45.5 590.0 73.1 1.293 0.0436058 10497222 Zfp704 158.7 5.9 122.8 9.3 1.292 0.0122623 10396402 Prkch 1403.2 53.8 1086.1 10.3 1.292 0.0043197 10600485 Dkc1 305.1 17.9 236.3 30.2 1.291 0.0454710 10410892 Rasa1 552.9 11.8 428.5 11.5 1.290 0.0013596 10451061 Runx2 496.8 34.3 385.1 20.5 1.290 0.0275943 10466794 Fam122a 146.4 8.7 113.6 4.5 1.289 0.0176670 10386423 Pld6 126.2 3.3 98.0 7.4 1.289 0.0086662 10347503 Cdk5r2 140.6 2.6 109.3 18.0 1.287 0.0482323 10472916 Cdca7 234.1 5.2 181.9 23.5 1.287 0.0277562 10599120 Dock11 1081.1 85.2 840.2 28.8 1.287 0.0345335 10398461 Ppp2r5c 863.3 2.0 671.7 9.3 1.285 0.0000422 10454809 Matr3 906.1 72.0 705.1 52.4 1.285 0.0446498 10456566 Mbd2 1656.0 99.0 1288.8 93.0 1.285 0.0254913 10535471 Rac1 3889.5 102.2 3027.8 341.6 1.285 0.0216555 10470893 Set 934.2 59.9 727.6 26.9 1.284 0.0215816 10595288 Tmem30a 842.8 36.5 656.8 0.4 1.283 0.0064249 10490773 Hnrnph2 709.3 44.2 553.3 6.0 1.282 0.0180525 10426827 Larp4 254.1 5.7 198.2 17.8 1.282 0.0123034 10508879 Fam46b 200.1 10.7 156.2 17.7 1.281 0.0374543 10598723 Ddx3x 3039.4 217.3 2372.8 116.3 1.281 0.0309603 10364702 Midn 427.1 25.4 333.6 16.4 1.281 0.0205058 10590445 Snrk 1016.4 59.0 794.4 58.5 1.279 0.0257079 10565461 Me3 162.4 12.7 127.0 4.3 1.279 0.0355405 10556133 Styx 366.6 13.2 286.6 19.6 1.279 0.0112408 10466573 Ostf1 2047.7 174.1 1600.9 90.3 1.279 0.0481590 10416464 Zc3h13 314.7 14.3 246.7 16.2 1.276 0.0154890 10432180 Ccnt1 383.1 14.6 300.6 4.3 1.275 0.0050964 10498076 Maml3 221.3 2.6 173.6 3.6 1.274 0.0004116 10498319 Serp1 3600.4 171.9 2828.9 321.4 1.273 0.0359316 10589361 Ccdc51 124.9 5.3 98.2 1.7 1.273 0.0070500 10475350 Serf2 840.3 13.1 660.6 7.4 1.272 0.0004397 10491455 Fxr1 830.9 30.6 653.8 39.4 1.271 0.0104610 10462228 Dmrt3 131.7 4.8 103.6 7.4 1.271 0.0130258 10374333 Ikzf1 727.2 7.1 572.4 48.0 1.271 0.0093273 10395932 Ctage5 748.6 27.9 589.5 0.0 1.270 0.0046496 10415693 Shisa2 138.8 9.7 109.3 0.7 1.270 0.0267885 10596796 Rbm6 234.5 0.5 184.7 1.8 1.269 0.0000189 10368011 Vta1 608.8 47.7 479.8 24.9 1.269 0.0422656 10401007 Ppp2r5e 341.7 11.7 269.3 22.6 1.269 0.0161265 10487208 Atp8b4 731.9 42.6 577.0 22.8 1.268 0.0197840 10487154 Secisbp2l 547.6 5.5 431.7 22.5 1.268 0.0027091 10458607 Lars 531.6 26.0 419.3 52.4 1.268 0.0447124 10479514 Col20a1 141.5 9.5 111.7 4.7 1.268 0.0285974 10407892 Cdc2l5 760.6 45.2 600.1 48.2 1.268 0.0319348 10516213 Akirin1 730.9 28.6 577.2 56.6 1.266 0.0247246 10531437 Scarb2 2075.9 72.5 1640.3 216.6 1.266 0.0409745 10371482 Hsp90b1 4092.5 214.0 3233.9 181.8 1.265 0.0191546 10383758 Tug1 573.9 35.0 453.5 34.1 1.265 0.0321115 10401595 Rps6kl1 126.9 6.1 100.4 6.7 1.263 0.0196980 10500677 Cd2 4365.7 209.4 3456.1 132.4 1.263 0.0129748 10394448 Pum2 1210.1 49.9 958.5 13.6 1.262 0.0069360 10401172 Vti1b 392.6 23.8 311.1 31.3 1.262 0.0434220 10508036 Snip1 170.0 9.0 134.8 6.1 1.261 0.0176666 10360544 Hnrnpu 2785.0 157.2 2209.2 172.6 1.261 0.0303226 10349868 Ppp1r15b 687.0 30.3 545.2 30.2 1.260 0.0143248 10602772 Rps6ka3 1501.9 24.8 1193.4 83.2 1.259 0.0074431 10388010 C1qbp 363.4 24.6 288.8 9.4 1.258 0.0292756 10495107 Adora3 166.1 9.7 132.1 9.1 1.257 0.0296160 10586844 Adam10 1389.3 12.5 1104.9 19.3 1.257 0.0002492 10431697 Abcd2 2706.5 123.2 2153.1 195.9 1.257 0.0279118 10390352 Kpnb1 1058.4 55.1 842.1 52.2 1.257 0.0221271 10399005 Crip1 453.9 10.5 361.2 29.1 1.257 0.0125380 10362596 Fyn 232.8 16.8 185.3 14.1 1.256 0.0470165 10420198 Ripk3 143.9 5.9 114.6 2.4 1.256 0.0076259 10374560 Zrsr1 132.4 3.6 105.4 0.7 1.256 0.0021007 10586157 Rpl4 4344.7 161.2 3459.6 211.0 1.256 0.0124133 10545940 Gmcl1 886.4 35.1 706.1 12.8 1.255 0.0068631 10515049 Kti12 135.5 9.1 108.0 6.2 1.255 0.0353868 10402336 Ddx24 563.0 44.9 449.5 1.7 1.252 0.0427240 10433656 Mkl2 609.9 30.8 487.0 22.9 1.252 0.0177697 10375145 Lcp2 1470.5 32.6 1174.8 146.8 1.252 0.0355626 10524844 Taok3 639.3 13.3 510.8 55.2 1.252 0.0248930 10513822 Stmn1 445.8 26.4 356.3 17.6 1.251 0.0260726 10428192 Pabpc1 6059.4 275.2 4843.5 237.4 1.251 0.0148950 10594590 Snx1 2156.9 119.8 1725.0 148.1 1.250 0.0357029 10347282 Rufy4 345.7 20.0 276.7 1.9 1.250 0.0191331 10547177 Rassf4 2712.6 164.5 2173.0 170.5 1.248 0.0381094 10346191 Stat1 881.4 68.2 706.3 37.9 1.248 0.0490640 10483110 Ifih1 378.6 14.9 303.4 10.4 1.248 0.0089608 10478196 Top1 624.8 29.5 501.0 11.1 1.247 0.0121513 10505374 Col27a1 145.4 8.4 116.6 1.1 1.247 0.0194084 10453459 Pnkd 192.9 3.6 154.8 9.1 1.246 0.0061450 10411332 Hmgcr 507.6 15.1 407.5 3.0 1.246 0.0031085 10455533 Eif1a 397.8 7.8 319.5 29.9 1.245 0.0185925 10548563 Ptp4a1 3525.5 222.6 2834.9 24.8 1.244 0.0254298 10428302 Klf10 795.1 50.4 639.5 50.8 1.243 0.0433629 10395227 Cog5 453.9 18.9 365.3 21.8 1.242 0.0165777 10540639 Ogg1 206.4 5.1 166.1 2.6 1.242 0.0021619 10493891 Ywhaz 4336.2 120.7 3490.8 29.1 1.242 0.0026598 10379654 Ap2b1 1115.5 82.0 898.7 11.2 1.241 0.0386349 10401138 Atp6v1d 1218.8 67.0 982.1 14.2 1.241 0.0183469 10546805 Ddx18 932.9 61.9 752.3 36.8 1.240 0.0365322 10556059 Rbmxl2 121.1 5.6 97.6 9.1 1.240 0.0347115 10572747 Tpm4 981.1 29.5 791.4 51.8 1.240 0.0123619 10515431 Kif2c 153.6 6.0 124.0 6.0 1.239 0.0125678 10582188 Gse1 166.5 6.3 134.4 6.6 1.239 0.0119770 10407173 Il6st 1455.1 38.6 1174.5 123.5 1.239 0.0290897 10529154 Nrbp1 197.3 13.3 159.7 9.3 1.236 0.0426369 10348858 Bok 133.8 1.7 108.4 13.4 1.234 0.0386082 10399636 Mrto4 307.9 3.5 249.5 34.2 1.234 0.0489941 10538413 Znrf2 787.0 9.5 638.7 4.3 1.232 0.0002776 10545298 Rmnd5a 630.0 15.8 511.7 42.2 1.231 0.0182062 10346914 Fastkd2 181.7 7.5 147.6 4.5 1.231 0.0112353 10595000 Tmod3 1561.1 38.6 1268.9 27.3 1.230 0.0028203 10582427 Cbfa2t3 128.3 9.5 104.3 1.7 1.230 0.0438943 10395672 Ap4s1 199.8 15.4 162.5 1.1 1.230 0.0476198 10527547 Mtif3 450.6 15.4 366.6 2.3 1.229 0.0053452 10398288 Yy1 840.5 27.8 684.0 51.5 1.229 0.0195219 10498313 Pgk1 815.8 18.8 664.3 54.9 1.228 0.0180971 10437594 Usp7 910.4 41.4 742.1 8.6 1.227 0.0124686 10441436 Snx9 585.8 35.5 477.6 11.4 1.226 0.0283290 10401805 Snw1 374.7 20.3 305.7 2.2 1.226 0.0199560 10476021 Sirpa 7454.5 412.8 6088.8 191.0 1.224 0.0243476 10362593 Npm1 1779.8 93.5 1454.2 112.5 1.224 0.0378207 10587419 Senp6 460.4 17.5 376.2 5.0 1.224 0.0079723 10373651 Olfr814 420.5 26.5 343.6 8.5 1.224 0.0321117 10531794 Wdfy3 801.9 57.1 655.5 24.6 1.223 0.0460583 10460841 Cdc42bpg 186.1 5.2 152.1 5.2 1.223 0.0055001 10590452 Abhd5 1738.0 41.5 1421.2 53.5 1.223 0.0047811 10469322 Vim 12063.5 90.4 9869.6 935.9 1.222 0.0216725 10488156 Kif16b 570.3 9.3 466.7 17.5 1.222 0.0028986 10362245 Epb4.1l2 1111.0 65.3 909.4 13.1 1.222 0.0262021 10398147 Papola 1809.5 32.0 1481.2 72.4 1.222 0.0053049 10394735 Pdia6 1733.5 80.3 1419.0 138.1 1.222 0.0444676 10588495 Dusp7 588.3 8.4 481.7 2.2 1.221 0.0004611 10399387 Msgn1 126.2 7.4 103.3 2.1 1.221 0.0265579 10385790 Hspa4 994.7 12.3 815.2 14.4 1.220 0.0006295 10425695 Srebf2 579.4 28.1 475.2 20.9 1.219 0.0218065 10483633 Sp3 442.2 29.2 362.7 16.2 1.219 0.0424690 10544089 Zc3hav1 440.7 11.6 362.0 8.9 1.217 0.0040733 10516576 Rbbp4 1103.0 35.5 907.0 50.5 1.216 0.0136727 10385511 Psme2 428.6 16.6 352.5 8.2 1.216 0.0101546 10470834 Spna2 956.0 62.2 786.3 37.9 1.216 0.0437398 10436561 Usp25 976.5 42.8 803.8 32.8 1.215 0.0175899 10415574 Ccni 2689.3 154.7 2214.3 48.0 1.215 0.0275878 10554701 Hnrnpk 4553.4 203.8 3750.0 38.4 1.214 0.0135128 10496159 Ints12 851.7 18.2 701.6 40.6 1.214 0.0095814 10384717 Pex13 219.7 11.7 181.0 14.1 1.214 0.0433043 10452701 Smchd1 496.4 29.0 409.0 2.0 1.214 0.0273620 10384555 Aftph 824.1 7.6 679.1 1.6 1.214 0.0001375 10544015 Ybx1 2448.6 157.2 2018.9 73.4 1.213 0.0399621 10399924 Pik3cg 1077.2 23.0 888.3 1.0 1.213 0.0016041 10411882 Nln 1096.1 52.4 903.8 44.2 1.213 0.0241830 10450006 Hnrnpm 1654.7 110.0 1364.7 57.1 1.212 0.0451102 10426042 Gramd4 781.2 29.9 644.5 17.0 1.212 0.0107529 10410560 Trip13 182.1 7.5 150.3 14.7 1.212 0.0446573 10584710 H2afx 305.4 14.6 252.0 15.3 1.212 0.0291543 10593605 Cul5 291.9 15.8 240.9 1.3 1.212 0.0227449 10403658 Gng4 122.6 2.3 101.4 6.0 1.210 0.0096858 10351140 Kifap3 241.5 8.8 199.6 2.4 1.210 0.0081204 10399640 Mrto4 385.6 15.7 319.0 10.6 1.209 0.0142092 10385118 Dock2 1731.4 82.3 1432.2 77.8 1.209 0.0270446 10514158 Psip1 121.1 5.0 100.2 4.6 1.209 0.0180606 10491922 Narg1 535.0 25.5 442.7 30.5 1.208 0.0341881 10594540 Plekho2 541.8 5.2 448.6 22.2 1.208 0.0047900 10395259 Nampt 1034.9 49.9 857.0 27.2 1.208 0.0209715 10347933 Sp140 288.0 8.9 238.8 17.3 1.206 0.0221862 10510874 Megf6 184.7 3.4 153.2 12.0 1.206 0.0190364 10390768 Smarce1 849.8 31.8 705.3 19.4 1.205 0.0112677 10471505 Sh2d3c 236.7 5.1 196.5 13.6 1.205 0.0156783 10375713 Mgat4b 988.3 53.8 821.5 9.8 1.203 0.0258164 10371811 Scyl2 1040.0 26.9 865.1 40.0 1.202 0.0092103 10586064 Anp32a 929.9 37.9 774.0 64.9 1.201 0.0390012 10463911 Add3 1005.4 50.5 837.0 7.3 1.201 0.0211343 10436471 Cggbp1 372.3 6.1 310.0 13.2 1.201 0.0049448 10408850 Nedd9 2026.9 23.9 1687.8 25.8 1.201 0.0006281 10511865 Ptges3 3086.8 61.9 2573.4 192.7 1.200 0.0192969 10506939 Eps15 918.6 24.0 765.9 61.8 1.199 0.0260491 10501265 Gnai3 1470.2 54.5 1226.4 53.2 1.199 0.0159412 10411974 Ipo11 366.2 7.7 305.9 1.4 1.197 0.0018894 10404700 Ubxn2a 700.0 42.5 586.1 13.0 1.194 0.0390921 10566926 Rnf141 683.9 5.1 573.1 16.2 1.193 0.0012948 10558410 Ptpre 479.1 3.0 401.8 5.5 1.192 0.0002301 10526319 Baz1b 591.3 34.0 496.2 25.6 1.192 0.0455252 10352234 Itpkb 566.4 32.5 475.7 0.5 1.191 0.0332413 10417895 Ppp3cb 758.9 18.5 637.6 25.5 1.190 0.0080541 10457022 Mbp 202.1 9.6 169.8 0.2 1.190 0.0203536 10491038 Tbl1xr1 753.8 29.7 633.4 27.9 1.190 0.0201294 10372766 Helb 272.1 4.2 228.7 13.7 1.190 0.0118182 10559175 Krtap5-5 192.7 7.7 162.0 9.5 1.189 0.0275078 10498623 Kpna4 322.2 8.4 271.2 9.7 1.188 0.0080832 10596275 Dnajc13 814.4 50.0 685.8 11.9 1.187 0.0424064 10577922 Hook3 478.3 25.9 403.7 21.4 1.185 0.0444378 10430725 St13 692.0 35.3 584.3 9.0 1.184 0.0274535 10418903 Gprin2 139.2 4.3 117.5 8.6 1.184 0.0298293 10509168 E2f2 186.3 8.2 157.5 1.4 1.183 0.0186380 10422396 Stk24 1226.1 28.7 1036.7 57.8 1.183 0.0146702 10446592 Dlgap1 249.4 5.4 211.0 16.3 1.182 0.0270552 10453006 Cebpz 299.7 5.1 253.8 3.4 1.181 0.0016268 10521587 Dnaja1 578.8 26.7 490.2 34.6 1.181 0.0463509 10361926 Map3k5 1224.5 65.0 1037.4 38.9 1.180 0.0378817 10370780 Pcsk4 130.7 7.2 110.8 2.0 1.180 0.0359198 10357332 Actr3 2131.5 63.9 1809.1 115.8 1.178 0.0251549 10483025 Rbms1 642.4 19.9 545.9 23.5 1.177 0.0153743 10503098 Lyn 2452.5 118.1 2085.4 0.3 1.176 0.0250836 10586781 Myo1e 1198.2 34.7 1019.3 51.9 1.176 0.0176928 10433940 Mapk1 1705.5 43.7 1450.8 15.7 1.176 0.0047609 10434806 Lpp 736.5 21.8 626.6 54.3 1.175 0.0445090 10406205 Erap1 772.2 26.6 657.3 40.3 1.175 0.0288354 10473919 Ckap5 403.3 14.0 343.3 8.4 1.175 0.0130953 10348817 Sept2 2045.7 78.2 1742.5 75.2 1.174 0.0231106 10513824 Cdk5rap2 227.2 6.7 193.6 10.2 1.174 0.0193281 10380665 Hoxb1 122.0 2.9 103.9 2.3 1.174 0.0055276 10478884 Snai1 132.3 4.0 112.8 0.5 1.173 0.0074762 10489958 Kcng1 161.7 9.6 137.9 0.0 1.172 0.0450495 10489891 B4galt5 896.0 19.8 764.4 40.4 1.172 0.0147261 10412177 Skiv2l2 657.3 12.0 561.2 44.5 1.171 0.0313855 10518585 Kif1b 511.4 16.4 436.7 5.1 1.171 0.0093820 10453825 Snrpd1 590.6 26.5 504.4 32.0 1.171 0.0449470 10603252 Larp4 723.0 37.5 617.5 12.4 1.171 0.0349769 10401781 Sptlc2 1489.2 24.3 1273.7 2.0 1.169 0.0012804 10574632 Cbfb 929.9 21.0 795.6 18.8 1.169 0.0054239 10511952 Orc3l 387.5 11.8 332.0 26.0 1.167 0.0422358 10356800 Hdlbp 1467.0 11.4 1257.1 89.2 1.167 0.0218580 10449292 Nkx2-5 165.9 8.1 142.2 4.2 1.166 0.0346504 10391963 Nsf 1221.8 63.2 1047.9 36.6 1.166 0.0419454 10556216 Ipo7 995.1 20.0 854.0 12.5 1.165 0.0032226 10453766 Thoc1 280.6 11.8 240.9 9.0 1.165 0.0284947 10430770 Tob2 180.2 5.6 154.8 1.4 1.164 0.0093148 10363639 Atoh7 423.2 18.7 363.8 1.8 1.163 0.0236833 10382797 Fam100b 379.5 11.4 326.4 25.3 1.163 0.0440495 10492815 Tmem154 1574.9 18.0 1355.0 80.0 1.162 0.0156353 10461721 Mpeg1 8605.8 141.9 7405.8 609.0 1.162 0.0380741 10423577 Mtdh 1042.2 49.2 897.0 9.8 1.162 0.0295221 10585022 Zfp259 336.2 13.8 289.4 12.1 1.162 0.0307487 10366310 Osbpl8 581.4 26.2 500.5 18.0 1.162 0.0336741 10461220 Hnrnpul2 1125.3 25.9 968.8 57.3 1.162 0.0222388 10515994 Smap2 1158.3 7.9 998.5 25.7 1.160 0.0016924 10527832 Pds5b 200.1 8.5 172.7 8.8 1.158 0.0402212 10348929 Hnrnpf 3559.4 185.4 3078.4 86.1 1.156 0.0454700 10412123 Ncf2 1928.1 77.5 1667.6 65.7 1.156 0.0305369 10526217 Rfc2 274.1 6.8 237.4 17.0 1.155 0.0377902 10391895 Arhgap27 246.1 7.0 213.3 1.5 1.154 0.0082966 10567049 Copb1 1326.2 46.6 1149.5 8.8 1.154 0.0150308 10587627 Cyb5r4 632.1 15.4 548.2 17.8 1.153 0.0109241 10421906 Diap3 208.7 1.8 181.1 8.3 1.152 0.0092567 10378579 Prpf8 1387.6 49.9 1207.9 11.8 1.149 0.0175452 10404848 Jarid2 379.4 14.7 330.3 3.3 1.149 0.0216080 10405094 Iars 672.3 19.0 585.4 29.1 1.149 0.0251288 10447341 Rhoq 268.8 8.2 234.1 2.1 1.148 0.0111941 10408197 Hist1h2bh 445.6 13.5 388.8 7.6 1.146 0.0134239 10466374 Tle4 356.2 8.6 310.8 21.5 1.146 0.0398150 10502510 Lmo4 2573.9 82.9 2249.4 82.9 1.144 0.0232913 10360806 Capn2 1380.1 35.0 1206.1 27.1 1.144 0.0099718 10476893 Gzf1 213.6 7.2 186.8 3.4 1.143 0.0181568 10388786 Supt6h 673.4 15.2 589.0 8.2 1.143 0.0060547 10353064 Arfgef1 851.0 29.2 744.9 18.2 1.142 0.0209563 10406417 Actg1 13123.4 481.3 11520.7 400.6 1.139 0.0309351 10553598 Cyfip1 1174.7 27.8 1031.5 59.9 1.139 0.0322137 10382935 Tnrc6c 294.9 10.0 259.1 11.4 1.138 0.0333564 10354677 Ankrd44 584.7 28.3 513.9 8.2 1.138 0.0463434 10483809 Nfe2l2 1171.4 10.2 1031.0 74.0 1.136 0.0385110 10361669 Katna1 448.4 19.1 394.7 6.0 1.136 0.0346361 10525711 Ogfod2 159.4 6.1 140.3 1.5 1.136 0.0251625 10597493 Stt3b 1425.8 38.0 1255.4 51.4 1.136 0.0225119 10500802 Atg4a 364.2 5.1 321.0 12.1 1.135 0.0101511 10393970 Fasn 266.8 7.4 235.5 1.4 1.133 0.0111957 10376868 Trpv2 2102.4 79.9 1856.0 11.8 1.133 0.0260117 10370911 Klf16 386.6 13.3 342.3 17.6 1.129 0.0471288 10397866 Golga5 224.8 6.4 199.2 9.6 1.128 0.0346469 10536818 Calu 1098.7 32.7 975.6 30.4 1.126 0.0242783 10367931 Ltv1 397.9 7.2 353.6 20.1 1.125 0.0334613 10461369 Ahnak 1067.8 40.7 949.1 25.8 1.125 0.0376443 10536273 Casd1 492.8 18.5 439.4 5.0 1.122 0.0320037 10437748 Gspt1 1184.0 51.1 1055.7 2.8 1.122 0.0435619 10351703 Copa 2402.1 5.8 2144.5 9.3 1.120 0.0000362 10533993 Slc15a4 581.5 11.0 519.2 14.1 1.120 0.0110567 10537246 Nup205 385.2 6.3 344.1 15.7 1.119 0.0227495 10397054 Dcaf4 167.5 5.2 149.7 3.8 1.119 0.0266712 10527441 Arpc1b 4143.0 157.0 3708.8 12.0 1.117 0.0341586 10391750 Gpatch8 164.2 7.1 147.0 1.0 1.117 0.0475032 10515257 Rad54l 135.3 4.0 121.4 5.4 1.114 0.0431117 10547251 Bms1 319.3 3.5 286.7 14.4 1.114 0.0268714 10528021 Hspa8 6313.7 205.1 5678.5 77.5 1.112 0.0277643 10406681 Ap3b1 804.4 22.8 725.2 30.2 1.109 0.0424855 10606393 Brwd3 189.6 2.5 171.0 3.7 1.109 0.0061817 10469358 Mrc1 4503.8 71.7 4065.7 203.9 1.108 0.0354655 10512709 Mcart1 418.0 9.4 377.7 10.8 1.107 0.0210182 10466843 Gapdh 8196.6 222.9 7410.8 144.2 1.106 0.0231294 10454077 Taf4b 205.0 7.0 185.7 4.4 1.104 0.0430475 10530163 Rfc1 344.6 12.7 313.1 2.5 1.100 0.0457925 10555389 Ucp2 7467.8 148.2 6788.4 37.1 1.100 0.0090386 10479268 Wtap 1342.0 10.3 1221.2 0.6 1.099 0.0005673 10518642 Ube4b 551.6 13.3 503.7 20.2 1.095 0.0457894 10540622 Brpf1 490.7 11.8 448.2 1.2 1.095 0.0168164 10468795 Rab11fip2 249.7 3.6 228.5 4.9 1.093 0.0104506 10502165 Sec24b 726.8 4.5 665.9 13.0 1.091 0.0041198 10603708 Cask 535.7 11.5 491.1 11.5 1.091 0.0236310 10365227 Ap3m1 1497.6 41.0 1373.9 1.7 1.090 0.0271132 10582712 Egln1 371.6 7.5 341.5 10.6 1.088 0.0317720 10434481 Eif4g1 1498.1 28.4 1378.5 54.6 1.087 0.0441662 10444824 H2-Q6 190.8 4.6 175.6 2.4 1.086 0.0255202 10415513 Parp4 346.6 4.3 319.6 14.7 1.085 0.0482637 10514985 Zyg11b 351.1 5.7 323.7 8.4 1.084 0.0214078 10533812 Sbno1 708.4 6.1 653.7 26.1 1.084 0.0323776 10450648 Abcf1 537.6 2.3 496.6 18.4 1.082 0.0252039 10577633 Golga7 722.5 17.0 667.7 18.5 1.082 0.0413436 10427336 Nckap1l 2194.6 8.6 2030.9 29.5 1.081 0.0023045 10467258 Myof 2270.7 23.0 2101.5 37.9 1.081 0.0076264 10349809 Rbbp5 346.2 6.7 320.7 6.9 1.079 0.0258510 10376864 Ubb 6221.1 95.1 5775.9 53.9 1.077 0.0100495 10393642 Eif4a3 194.9 4.5 181.0 1.5 1.077 0.0274780 10436182 Cd47 4564.5 92.9 4262.9 27.0 1.071 0.0236051 10588893 Rhoa 3155.7 58.5 2951.9 47.9 1.069 0.0271967 10471784 Rabgap1 509.6 9.3 477.9 8.0 1.066 0.0296528 10378855 Ssh2 414.7 8.2 389.3 7.7 1.066 0.0404166 10514668 Jak1 1528.1 17.1 1435.0 49.4 1.065 0.0488832 10434888 Opa1 623.2 9.4 585.5 16.5 1.064 0.0428571 10450699 H2-Q2 691.6 7.3 650.3 0.7 1.063 0.0047928 10468253 Nt5c2 761.2 17.6 716.3 6.5 1.063 0.0452990 10347873 Agfg1 1170.3 12.7 1106.1 32.1 1.058 0.0454468 10403558 Ero1lb 288.1 5.5 274.2 2.0 1.051 0.0463111 10523955 Dr1 1199.6 12.9 1142.4 15.4 1.050 0.0197716 10394627 Nbas 233.1 2.4 224.3 1.7 1.039 0.0224671 Supplemental Table 4. Upregulated genes in lung macrophages from LysM-cre x PPARgflox/flox mice.

CTRL - mean LysMcre x PPARfl/fl - ProbeSet Gene normalized SD mean normalized SD fold T-test ID Symbol signal intensity signal intensity 10493820 S100a6 78.6 22.7 909.7 268.5 11.57 0.0100 10358555 Hmcn1 37.0 5.0 262.1 46.2 7.09 0.0028 10500204 Ecm1 111.1 7.9 757.9 105.2 6.82 0.0014 10379727 Gm11428 149.5 32.4 996.1 364.7 6.66 0.0222 10548314 Klrb1b 96.1 30.3 372.5 128.8 3.88 0.0307 10419736 Dad1 548.5 61.4 2113.0 294.7 3.85 0.0024 10493812 S100a4 51.2 6.0 194.6 4.6 3.80 0.0001 10570590 Spag11b 95.3 27.0 361.3 129.5 3.79 0.0334 10450154 H2-Aa 354.8 126.2 1340.6 17.5 3.78 0.0019 10402783 Ahnak2 337.0 42.3 1233.9 56.9 3.66 0.0003 10354374 Slc40a1 98.6 5.9 346.5 43.9 3.51 0.0018 10453747 Colec12 98.1 5.5 340.3 59.4 3.47 0.0046 10546421 Prickle2 90.5 20.1 313.8 96.7 3.47 0.0246 10389590 Gdpd1 69.1 12.4 231.6 24.5 3.35 0.0020 10583100 Mmp8 268.2 44.1 886.8 214.5 3.31 0.0134 10509577 Pla2g2d 59.6 8.8 194.2 28.4 3.26 0.0038 10444291 H2-Ab1 313.3 65.1 1020.7 66.4 3.26 0.0013 10518147 Pdpn 184.3 26.0 589.4 125.9 3.20 0.0099 10445078 Gabbr1 115.1 0.4 356.7 23.0 3.10 0.0003 10393559 Timp2 310.5 27.4 945.4 119.1 3.04 0.0024 10563108 Snord35a 273.2 90.8 828.6 104.9 3.03 0.0079 10489343 Ptpla 45.3 8.4 135.7 7.1 3.00 0.0011 10354506 Mfsd6 62.5 12.9 186.6 13.0 2.99 0.0018 10509441 Ece1 71.7 7.2 205.9 37.6 2.87 0.0073 10367746 Sash1 91.9 1.0 258.1 56.7 2.81 0.0115 10592266 Slc37a2 127.6 6.5 357.5 39.4 2.80 0.0017 10360684 Ephx1 108.9 16.8 302.7 14.9 2.78 0.0010 10561008 Ceacam1 79.4 4.1 215.9 25.2 2.72 0.0021 10432509 Uxt 238.2 45.9 645.3 102.2 2.71 0.0078 10474064 Trp53i11 231.4 9.7 626.4 58.0 2.71 0.0011 10417734 Nr1d2 134.2 12.5 362.4 58.8 2.70 0.0059 10383756 Ifitm2 156.8 22.2 415.5 42.9 2.65 0.0027 10578264 Msr1 86.9 15.6 228.2 37.7 2.63 0.0087 10607877 Prps2 215.1 31.9 564.4 25.8 2.62 0.0010 10471721 Ptgs1 135.7 6.8 353.7 53.6 2.61 0.0047 10563099 Snord35b 326.9 104.5 843.8 113.8 2.58 0.0134 10603833 Usmg5 710.5 241.5 1819.7 65.8 2.56 0.0091 10467979 Scd1 98.3 5.9 250.9 18.7 2.55 0.0008 10370552 Ppap2c 130.7 13.0 333.3 50.5 2.55 0.0056 10408870 Tbc1d7 49.3 10.9 124.2 11.0 2.52 0.0049 10373702 Pisd-ps1 267.7 52.2 673.3 47.6 2.52 0.0031 10526853 Fam20c 52.6 2.4 128.5 34.5 2.44 0.0254 10379344 Gm10387 67.9 5.2 165.5 52.4 2.44 0.0396 10392056 Cyb561 292.3 25.5 710.3 64.4 2.43 0.0017 10439312 Cd86 115.6 28.8 280.8 9.9 2.43 0.0049 10371616 Chpt1 106.9 5.4 259.1 42.2 2.42 0.0067 10387699 Centb1 140.7 9.4 336.0 15.6 2.39 0.0004 10490903 Car13 78.7 5.3 187.1 35.8 2.38 0.0111 10449018 Haghl 150.3 10.2 355.0 31.2 2.36 0.0015 10564713 Mfge8 100.5 8.7 236.3 1.7 2.35 0.0002 10444298 H2-Eb1 183.1 32.9 429.7 52.5 2.35 0.0069 10563441 Emp3 1431.3 269.2 3358.5 336.5 2.35 0.0055 10370497 Pdxk 313.5 9.1 734.8 13.9 2.34 0.0000 10404063 Hist1h2ab 55.9 15.0 129.8 28.1 2.32 0.0283 10451395 Klc4 162.1 21.5 375.9 5.0 2.32 0.0009 10569200 Polr2l 452.6 47.1 1048.1 22.0 2.32 0.0005 10545014 Vopp1 320.4 9.4 737.6 102.0 2.30 0.0046 10573939 Lpcat2 139.2 9.0 319.9 80.3 2.30 0.0244 10472350 Gca 166.6 20.5 382.7 37.7 2.30 0.0033 10447517 Pisd-ps2 153.2 31.1 351.6 42.5 2.29 0.0086 10391669 Slc25a39 786.7 30.5 1795.8 313.1 2.28 0.0090 10382438 Cd300a 149.7 16.5 340.3 93.3 2.27 0.0329 10578613 Rps16 3291.5 245.1 7469.5 480.5 2.27 0.0009 10365559 Igf1 117.1 12.5 265.0 16.9 2.26 0.0014 10463355 Scd2 388.5 56.3 877.9 114.3 2.26 0.0069 10533345 Aldh2 434.1 44.9 971.2 48.0 2.24 0.0010 10387816 Rnasek 1183.4 108.3 2643.7 116.4 2.23 0.0007 10390075 Gm11545 107.0 10.3 238.8 54.8 2.23 0.0216 10386844 Zswim7 98.7 6.6 219.6 2.2 2.23 0.0002 10497673 Zmat3 106.5 17.7 235.2 15.6 2.21 0.0037 10465633 Cox8a 395.9 2.5 873.1 142.0 2.21 0.0078 10361098 Nenf 165.7 29.9 365.1 62.4 2.20 0.0152 10430778 Phf5a 345.0 70.2 758.8 126.6 2.20 0.0164 10376216 Slc36a1 247.0 27.4 540.3 29.2 2.19 0.0014 10416302 Hr 159.2 12.2 347.7 65.2 2.18 0.0131 10390560 Stac2 75.4 5.5 162.9 20.8 2.16 0.0049 10497752 Carhsp1 265.9 45.8 569.4 106.4 2.14 0.0191 10355456 Mreg 114.7 5.2 245.0 14.9 2.14 0.0007 10590972 Gm16379 454.3 25.5 968.4 30.9 2.13 0.0003 10360028 Fcgr2b 643.5 66.4 1371.1 75.9 2.13 0.0014 10437174 Wrb 165.4 43.0 352.3 78.4 2.13 0.0374 10413047 Plau 124.8 26.2 265.5 42.2 2.13 0.0177 10587107 Myo5a 258.1 16.4 548.4 23.4 2.12 0.0005 10507594 Slc2a1 162.0 20.8 342.3 77.8 2.11 0.0260 10532289 Crlf2 191.2 13.4 403.9 1.0 2.11 0.0002 10456005 Cd74 692.4 130.6 1461.2 245.9 2.11 0.0178 10526508 Fis1 759.7 105.4 1600.7 99.5 2.11 0.0030 10600301 Ssr4 493.2 92.6 1038.2 1.5 2.11 0.0042 10529239 Pisd 278.6 19.0 583.8 83.7 2.10 0.0071 10559233 Mrpl23 337.9 40.7 707.0 52.6 2.09 0.0029 10357391 Zranb3 158.6 8.1 329.5 95.6 2.08 0.0435 10547100 Plxnd1 533.1 45.8 1102.5 195.7 2.07 0.0135 10538547 Fkbp9 87.3 7.3 179.9 14.4 2.06 0.0022 10598013 Ccr5 90.2 14.9 185.8 26.5 2.06 0.0128 10607868 Tlr8 801.8 21.5 1648.4 54.7 2.06 0.0001 10569504 Tnfrsf23 239.6 52.7 488.9 48.4 2.04 0.0129 10383556 Fn3krp 82.5 13.2 167.4 14.4 2.03 0.0064 10457359 Mpp7 155.5 23.4 315.4 5.4 2.03 0.0029 10355550 Il8ra 155.5 21.8 315.3 46.7 2.03 0.0124 10551724 Yif1b 284.0 19.5 575.4 84.8 2.03 0.0084 10480714 Uap1l1 578.7 41.5 1162.8 82.4 2.01 0.0016 10349051 Tnfrsf11a 160.1 7.7 321.0 17.5 2.01 0.0007 10447383 Epcam 569.2 12.1 1140.8 197.1 2.00 0.0120 10568328 Vkorc1 428.9 38.2 856.4 22.6 2.00 0.0008 10560624 Apoe 451.9 60.3 901.2 131.9 1.99 0.0123 10561806 Mif 439.1 14.9 874.5 16.4 1.99 0.0001 10385391 Cyfip2 81.1 12.1 161.5 5.1 1.99 0.0034 10489646 Slc35c2 546.5 13.6 1087.7 117.5 1.99 0.0033 10397148 Acot1 189.9 36.8 374.6 48.0 1.97 0.0158 10542200 Gabarapl1 322.4 61.6 635.6 47.9 1.97 0.0094 10562709 Cd33 1114.5 158.4 2196.6 106.7 1.97 0.0037 10529485 Htra3 81.5 4.8 160.4 9.5 1.97 0.0010 10527936 Fzd1 178.1 20.0 350.5 32.3 1.97 0.0047 10390519 Plxdc1 241.4 16.7 474.3 38.2 1.96 0.0022 10560911 Rabac1 525.5 52.4 1031.3 113.9 1.96 0.0058 10459802 Gm9028 189.1 27.2 370.8 1.2 1.96 0.0029 10364696 Atp5d 878.5 101.2 1721.8 235.9 1.96 0.0102 10425808 Tspo 421.8 33.7 824.6 96.6 1.95 0.0058 10461354 Tut1 129.2 16.3 252.4 12.2 1.95 0.0029 10485388 Ldlrad3 204.5 22.3 399.0 2.0 1.95 0.0014 10449452 Fkbp5 498.3 24.3 967.0 249.3 1.94 0.0385 10394082 Hexdc 77.4 9.2 149.8 36.2 1.94 0.0376 10363528 Aifm2 235.9 13.8 456.5 102.1 1.94 0.0275 10552125 Pepd 411.8 43.5 795.8 172.8 1.93 0.0285 10588083 Faim 156.9 31.1 301.9 60.8 1.92 0.0351 10561063 Bckdha 276.8 18.8 529.0 53.6 1.91 0.0041 10499309 Apoa1bp 307.9 35.2 586.4 39.9 1.90 0.0037 10388861 Tmem199 146.7 19.4 278.0 18.9 1.90 0.0050 10560816 Atp5g2 1072.5 123.7 2029.9 285.2 1.89 0.0123 10466248 Stx3 113.9 8.5 215.4 24.0 1.89 0.0056 10440918 Tmem50b 488.4 40.2 923.7 3.1 1.89 0.0007 10411393 Rps18 2969.8 461.3 5616.1 857.1 1.89 0.0186 10558948 Cd151 260.0 29.7 490.7 7.0 1.89 0.0020 10449034 Fam173a 316.6 16.6 597.2 63.2 1.89 0.0042 10420155 Dhrs1 546.0 82.9 1025.9 13.5 1.88 0.0045 10575706 Wwox 174.9 13.4 328.1 49.9 1.88 0.0122 10410508 Ndufs6 288.7 39.9 541.2 3.0 1.87 0.0034 10562096 Tmem147 166.9 26.5 312.1 34.7 1.87 0.0124 10364280 Pttg1ip 892.1 135.0 1667.5 115.2 1.87 0.0071 10558919 Snora52 654.5 99.0 1223.1 307.1 1.87 0.0495 10383012 Pgs1 150.2 8.2 280.6 41.1 1.87 0.0103 10550394 Ptgir 127.1 8.2 237.3 31.7 1.87 0.0085 10539435 Bola3 237.0 16.9 442.3 31.3 1.87 0.0022 10401320 Adam4 67.0 18.0 125.0 22.7 1.87 0.0484 10538957 Eif2ak3 74.7 8.7 139.0 0.4 1.86 0.0022 10471519 Tor2a 283.8 19.1 527.7 20.4 1.86 0.0008 10569485 Tnfrsf26 398.2 32.6 740.3 108.4 1.86 0.0118 10532169 Mfsd7a 205.6 24.3 381.5 59.3 1.86 0.0166 10420372 Cryl1 366.4 31.8 679.5 45.5 1.85 0.0026 10354220 Mfsd9 106.5 19.5 197.4 2.6 1.85 0.0084 10426544 Slc48a1 811.5 50.3 1503.9 116.5 1.85 0.0024 10418927 Bmpr1a 97.1 6.2 179.9 16.1 1.85 0.0033 10444236 H2-DMb2 484.2 97.2 896.9 119.7 1.85 0.0232 10568988 Bet1l 192.0 17.9 355.1 15.9 1.85 0.0019 10547088 Mbd4 142.7 5.7 264.0 7.0 1.85 0.0002 10594638 Aph1c 184.4 24.9 340.5 57.8 1.85 0.0220 10351259 Slc19a2 125.6 1.2 232.0 16.2 1.85 0.0011 10535458 Zdhhc4 310.0 26.3 571.6 140.0 1.84 0.0417 10451893 Stap2 75.9 5.2 139.7 18.5 1.84 0.0089 10406676 Lhfpl2 360.4 48.8 663.2 154.3 1.84 0.0425 10438098 Sdf2l1 371.5 48.8 682.9 114.0 1.84 0.0213 10590365 Vipr1 121.5 8.8 223.3 26.5 1.84 0.0071 10378341 Shpk 72.2 1.4 132.7 15.9 1.84 0.0056 10400470 Cox6c 1063.8 136.0 1955.0 150.5 1.84 0.0062 10421172 Slc25a37 148.6 14.2 272.9 8.9 1.84 0.0017 10507471 Gm13015 344.7 23.2 633.1 4.6 1.84 0.0005 10419874 Slc22a17 182.2 3.9 334.1 22.3 1.83 0.0011 10604100 Ndufa1 289.8 55.9 530.9 1.0 1.83 0.0103 10513162 Ptpn3 140.2 9.4 256.8 15.0 1.83 0.0016 10545751 Tex261 610.5 70.7 1117.8 206.6 1.83 0.0247 10545697 Dguok 212.2 31.6 388.2 19.4 1.83 0.0063 10505008 Slc44a1 83.1 1.2 152.0 2.4 1.83 0.0000 10566281 Dnajc19 251.9 59.3 460.5 51.3 1.83 0.0275 10463173 Zdhhc16 133.2 9.1 243.2 19.1 1.83 0.0028 10544462 Fam115a 169.7 9.2 309.7 33.7 1.83 0.0052 10572647 Slc27a1 260.4 17.7 474.6 27.7 1.82 0.0017 10356475 Arl4c 78.3 4.3 142.1 23.7 1.82 0.0159 10471036 Dolpp1 225.9 6.9 409.7 56.7 1.81 0.0090 10537712 Gstk1 119.4 32.2 216.4 34.5 1.81 0.0487 10518455 Agtrap 239.1 17.7 433.0 48.3 1.81 0.0066 10351644 Cd244 330.0 15.8 596.5 33.5 1.81 0.0011 10551347 Blvrb 241.2 30.7 435.7 48.7 1.81 0.0109 10405287 Higd2a 891.4 87.2 1603.3 149.0 1.80 0.0060 10448748 Nubp2 443.9 49.6 798.3 29.7 1.80 0.0031 10424252 Wdyhv1 221.2 14.3 397.6 84.6 1.80 0.0310 10582171 Zdhhc7 245.8 6.0 441.8 21.8 1.80 0.0005 10456071 Csf1r 893.6 51.1 1605.8 29.6 1.80 0.0004 10591739 Acp5 1036.5 29.7 1859.9 80.4 1.79 0.0004 10557754 Orai3 290.9 23.0 521.7 29.7 1.79 0.0022 10539111 Tmem150 121.7 6.5 218.0 47.5 1.79 0.0325 10461237 Bscl2 210.0 4.2 375.8 83.6 1.79 0.0330 10379401 Rnf135 82.5 3.6 147.5 21.5 1.79 0.0113 10493789 S100a13 399.6 15.0 714.7 32.5 1.79 0.0006 10460392 Pold4 352.6 32.0 630.5 82.9 1.79 0.0113 10517328 Tmem50a 1791.9 214.4 3190.8 13.6 1.78 0.0031 10560304 Calm3 949.6 66.4 1690.2 78.2 1.78 0.0014 10452316 C3 1015.6 134.4 1807.3 4.2 1.78 0.0042 10512949 Abca1 772.1 91.9 1373.5 83.5 1.78 0.0051 10500295 Plekho1 237.6 28.1 422.7 76.2 1.78 0.0264 10391100 Atp5g1 331.8 29.6 590.2 9.8 1.78 0.0015 10442691 Clcn7 442.5 2.3 787.0 73.1 1.78 0.0030 10397507 Gstz1 81.8 11.7 145.3 8.8 1.78 0.0077 10579724 Slc35e1 397.5 34.6 705.1 105.1 1.77 0.0151 10391454 Vat1 673.1 71.5 1192.4 272.0 1.77 0.0426 10525439 P2rx4 470.5 33.3 832.7 60.5 1.77 0.0029 10401128 Max 327.0 41.0 578.5 15.1 1.77 0.0041 10517996 Plekhm2 458.0 21.5 810.3 49.4 1.77 0.0014 10580160 Mri1 161.3 19.1 285.3 13.3 1.77 0.0044 10525086 Slc24a6 496.3 24.0 877.6 90.3 1.77 0.0049 10580085 Dcaf15 110.5 2.2 195.1 15.8 1.77 0.0021 10479463 Slc17a9 135.6 10.3 239.2 34.0 1.76 0.0130 10395129 Tmem18 195.7 28.1 345.0 42.6 1.76 0.0166 10559919 Zfp772 71.0 2.2 125.0 1.2 1.76 0.0001 10582303 Cyba 1958.8 143.0 3448.1 692.0 1.76 0.0295 10450206 Rnf5 277.8 10.8 488.9 24.6 1.76 0.0008 10378649 Slc43a2 289.4 5.3 509.2 11.3 1.76 0.0001 10574899 Nutf2 112.8 13.5 198.5 41.5 1.76 0.0380 10359428 Aph1a 830.1 61.8 1460.1 6.0 1.76 0.0009 10478487 Sys1 147.9 12.3 259.8 40.6 1.76 0.0172 10385699 Rmnd5b 328.6 28.2 576.9 72.9 1.76 0.0109 10515242 Nsun4 74.2 6.1 130.2 0.0 1.75 0.0012 10598771 Maoa 123.6 25.0 216.7 36.7 1.75 0.0404 10547009 Vgll4 281.8 6.6 494.3 117.0 1.75 0.0414 10384138 Tmed4 384.1 49.7 673.5 72.9 1.75 0.0123 10364744 Ndufs7 487.5 42.4 854.6 28.1 1.75 0.0018 10429859 Oplah 150.4 8.8 263.3 5.6 1.75 0.0006 10545910 Pcyox1 1586.4 56.8 2774.3 135.4 1.75 0.0007 10569152 Pddc1 249.8 27.9 436.4 47.6 1.75 0.0105 10406614 Mtx3 98.0 18.8 171.1 19.9 1.75 0.0250 10569494 Tnfrsf22 210.2 27.1 366.8 64.7 1.74 0.0290 10448582 Mlst8 214.1 22.8 373.6 44.9 1.74 0.0120 10379068 Sdf2 234.2 20.7 408.5 35.3 1.74 0.0055 10520612 Khk 153.6 9.4 267.8 30.1 1.74 0.0071 10436783 Sod1 882.6 69.4 1535.1 136.9 1.74 0.0052 10347980 Itm2c 668.6 71.6 1162.8 20.6 1.74 0.0028 10539517 Dysf 82.1 10.4 142.6 11.8 1.74 0.0089 10381304 Vps25 500.8 81.7 869.9 56.2 1.74 0.0121 10528583 Cdk5 290.0 20.9 503.4 24.3 1.74 0.0018 10374356 Vstm2a 387.9 55.7 673.5 64.2 1.74 0.0129 10560434 Qpctl 188.6 20.3 326.8 13.4 1.73 0.0037 10534728 Slc12a9 207.4 6.2 359.2 20.0 1.73 0.0009 10572449 Lsm4 537.2 23.1 930.1 55.7 1.73 0.0014 10552824 Rras 359.3 41.4 621.8 133.6 1.73 0.0420 10588876 Nicn1 153.6 9.8 265.8 11.6 1.73 0.0013 10549615 Leng8 416.9 60.6 721.4 3.1 1.73 0.0067 10489463 Slpi 360.3 19.5 623.4 98.0 1.73 0.0163 10538658 Herc3 108.0 6.0 186.7 4.4 1.73 0.0006 10562911 Tbc1d17 235.5 10.5 406.7 50.8 1.73 0.0087 10593918 Ppcdc 182.2 8.7 314.4 49.0 1.73 0.0157 10395831 Brms1l 126.2 12.6 217.8 8.7 1.72 0.0031 10546710 Shq1 165.7 16.2 285.7 54.5 1.72 0.0309 10469816 Il1rn 491.6 44.9 847.4 115.6 1.72 0.0144 10557326 Il4ra 863.9 45.8 1488.8 356.9 1.72 0.0468 10442616 Hagh 375.3 13.7 646.7 1.5 1.72 0.0001 10527043 Amz1 454.3 10.3 782.6 85.5 1.72 0.0056 10398859 Adssl1 80.6 1.7 138.8 4.3 1.72 0.0002 10590245 Slc25a38 209.7 6.1 360.6 48.3 1.72 0.0100 10405280 Arl10 132.8 7.1 228.5 8.9 1.72 0.0009 10391407 Ccdc56 395.3 33.3 679.9 47.9 1.72 0.0040 10502823 Dnajb4 106.7 6.7 183.4 25.8 1.72 0.0130 10519224 Pusl1 144.6 6.3 248.5 10.4 1.72 0.0007 10360090 Ppox 222.1 18.9 381.7 4.3 1.72 0.0015 10570018 Tnfsf13b 169.2 37.6 290.7 37.1 1.72 0.0380 10465580 Nudt22 193.2 16.3 331.8 1.0 1.72 0.0014 10549546 Ndufa3 462.3 36.9 793.6 57.8 1.72 0.0040 10540659 Ttll3 246.3 38.9 422.3 12.4 1.71 0.0096 10364361 Icosl 266.7 30.9 457.2 31.3 1.71 0.0067 10551426 Zfp59 267.6 25.9 458.3 26.2 1.71 0.0040 10460517 Brms1 212.8 15.8 364.5 45.3 1.71 0.0107 10589329 Pfkfb4 401.5 59.4 687.7 50.1 1.71 0.0115 10481147 Surf4 685.1 59.5 1172.4 149.5 1.71 0.0125 10574656 Fbxl8 94.4 4.6 161.5 11.5 1.71 0.0024 10402262 Gm2701 466.2 87.5 797.5 45.9 1.71 0.0176 10400189 Gm7172 494.7 35.6 845.4 125.5 1.71 0.0161 10512487 Rmrp 2511.5 177.2 4288.9 545.3 1.71 0.0111 10382470 Tmem104 317.9 16.0 542.7 7.0 1.71 0.0004 10551173 Exosc5 237.7 12.4 405.2 39.9 1.71 0.0053 10596900 Tcta 108.3 7.0 184.5 17.2 1.70 0.0053 10496771 Mcoln2 124.7 7.9 212.4 11.4 1.70 0.0019 10557481 Ypel3 431.6 22.6 735.1 140.8 1.70 0.0282 10351623 F11r 1352.3 100.5 2302.9 295.2 1.70 0.0118 10519219 Gltpd1 109.9 7.5 187.0 6.3 1.70 0.0013 10500100 Tnfaip8l2 612.3 82.7 1041.8 19.8 1.70 0.0063 10348645 Gpr35 94.5 3.9 160.6 12.6 1.70 0.0028 10381462 Rdm1 114.9 12.5 195.3 9.8 1.70 0.0048 10383575 Tbcd 251.8 9.1 427.6 31.4 1.70 0.0022 10464924 Rab1b 1055.0 69.7 1791.5 21.8 1.70 0.0008 10474201 Lmo2 526.1 63.8 892.9 32.8 1.70 0.0054 10541877 Vamp1 160.3 17.0 271.9 9.7 1.70 0.0039 10355785 Glb1l 91.2 7.9 154.7 24.2 1.70 0.0203 10424676 Ly6e 1912.2 93.6 3238.9 170.7 1.69 0.0014 10549932 Vmn2r50 81.8 3.7 138.5 5.9 1.69 0.0008 10345504 Cox5b 941.7 99.7 1594.1 163.8 1.69 0.0106 10481368 Trub2 193.0 9.8 326.3 44.5 1.69 0.0123 10394593 Fam49a 172.5 7.7 291.5 12.3 1.69 0.0008 10541785 Acrbp 85.9 2.1 145.2 17.2 1.69 0.0076 10516932 Sesn2 184.5 16.2 311.7 18.7 1.69 0.0039 10471062 Mettl11a 167.0 1.2 281.9 20.7 1.69 0.0018 10393728 Slc38a10 394.5 28.6 665.3 143.9 1.69 0.0413 10449266 Itfg3 300.0 32.0 505.6 10.4 1.69 0.0035 10437399 Coro7 252.7 5.5 425.7 33.8 1.68 0.0025 10470446 Rxra 602.3 36.7 1014.0 157.1 1.68 0.0180 10432032 Vdr 197.0 25.9 331.2 59.2 1.68 0.0352 10407291 Arl15 100.1 15.0 168.3 6.3 1.68 0.0100 10480652 Ndor1 151.9 11.6 254.7 1.4 1.68 0.0013 10415662 Rcbtb1 129.0 9.4 216.1 2.4 1.67 0.0012 10508135 Trappc3 768.9 151.9 1286.6 162.4 1.67 0.0356 10492757 Plrg1 461.4 57.7 772.0 92.6 1.67 0.0174 10404763 Tmem170b 385.7 62.6 644.7 49.5 1.67 0.0168 10517600 Pink1 216.0 13.9 361.0 34.7 1.67 0.0062 10597413 Crtap 112.2 11.3 187.4 25.8 1.67 0.0182 10474541 Nop10 317.0 48.4 529.2 29.9 1.67 0.0125 10391348 Fam134c 350.5 24.1 585.0 8.4 1.67 0.0011 10468893 Csf2ra 993.4 42.9 1657.8 101.5 1.67 0.0018 10589004 Qars 575.8 84.9 960.0 15.2 1.67 0.0092 10359181 Tor3a 216.5 19.9 360.6 19.7 1.67 0.0041 10599962 Mamld1 172.3 8.3 287.0 26.1 1.67 0.0047 10537347 Gm7504 276.0 63.8 459.6 20.7 1.67 0.0328 10582474 Chmp1a 452.3 55.7 752.6 97.7 1.66 0.0200 10518735 Spsb1 104.0 7.1 173.0 2.9 1.66 0.0011 10587639 Nt5e 286.0 16.2 475.5 23.9 1.66 0.0017 10382369 Rpl38 1828.0 297.4 3037.8 580.5 1.66 0.0493 10546791 Sumf1 527.1 26.6 874.5 86.6 1.66 0.0060 10415021 Abhd4 265.5 52.4 440.3 3.0 1.66 0.0208 10388086 Nlrp1c 123.7 23.1 205.1 13.8 1.66 0.0223 10445781 Trem2 187.5 9.4 310.8 13.1 1.66 0.0011 10501235 Gstm4 237.0 31.9 392.7 7.8 1.66 0.0076 10559644 Tmem224 179.6 7.0 297.4 31.2 1.66 0.0064 10413559 Rft1 158.0 10.4 261.6 49.3 1.66 0.0315 10545827 Rab11fip5 183.6 27.0 303.7 33.2 1.65 0.0205 10524020 Tmem175 154.9 8.1 256.3 9.5 1.65 0.0010 10445565 Mrpl2 278.0 34.3 459.7 74.2 1.65 0.0302 10578149 Leprotl1 992.5 72.6 1639.7 288.1 1.65 0.0277 10469457 Plxdc2 356.0 6.2 587.9 6.5 1.65 0.0000 10526842 Zfp157 111.0 3.9 183.2 6.4 1.65 0.0005 10592471 Gramd1b 154.4 8.8 254.7 11.6 1.65 0.0015 10406031 Lpcat1 122.5 1.0 202.2 17.2 1.65 0.0031 10379153 Aldoc 506.3 79.6 835.3 21.9 1.65 0.0122 10451167 Tmem63b 180.5 21.2 297.6 22.9 1.65 0.0097 10587818 Plscr4 139.9 18.0 230.6 7.8 1.65 0.0075 10442904 Jmjd8 320.7 45.9 528.5 26.7 1.65 0.0112 10388734 Eral1 159.3 28.2 262.5 14.9 1.65 0.0194 10467852 Slc25a28 266.1 17.0 438.2 8.3 1.65 0.0010 10573434 Farsa 176.5 9.6 290.7 39.6 1.65 0.0140 10476952 Entpd6 183.6 14.9 302.4 53.7 1.65 0.0299 10381211 Naglu 413.2 49.7 680.2 88.0 1.65 0.0205 10494574 Prkab2 134.6 12.1 221.6 9.6 1.65 0.0035 10545394 Rnf181 357.1 28.4 587.5 8.9 1.65 0.0018 10478540 Wfdc10 156.1 17.3 256.8 11.5 1.64 0.0058 10525419 P2rx7 240.6 19.2 395.6 2.7 1.64 0.0017 10437541 Nagpa 477.2 42.1 784.4 92.2 1.64 0.0130 10549653 Atp6v0c 2345.1 190.6 3854.1 203.1 1.64 0.0034 10521830 Slc35a4 636.0 51.6 1044.1 198.8 1.64 0.0354 10488797 Pxmp4 478.0 39.9 784.5 108.8 1.64 0.0178 10465508 Gpr137 148.0 5.9 243.0 24.5 1.64 0.0061 10473880 Lrp4 232.2 4.7 381.1 25.9 1.64 0.0018 10470555 Gbgt1 594.9 37.6 974.6 127.7 1.64 0.0138 10544199 Dennd2a 180.7 10.2 295.8 16.6 1.64 0.0022 10429957 Fbxl6 199.7 25.8 326.9 0.7 1.64 0.0071 10426891 Mettl7a1 118.8 7.3 194.4 3.4 1.64 0.0009 10451907 Sh3gl1 283.1 4.5 463.2 27.3 1.64 0.0012 10602062 Prps1 371.0 67.7 606.7 21.8 1.64 0.0199 10431014 Vkorc1l1 877.4 83.1 1434.6 104.4 1.64 0.0067 10420089 Nedd8 997.4 145.1 1630.8 52.1 1.64 0.0108 10435443 Hspbap1 244.1 14.5 398.9 9.6 1.63 0.0010 10412607 Abhd6 152.0 9.0 248.1 21.1 1.63 0.0051 10431017 Ttll1 119.8 9.2 195.4 7.4 1.63 0.0024 10484920 Ptpmt1 227.3 22.6 370.8 3.5 1.63 0.0035 10529375 Mxd4 398.4 16.3 649.7 24.2 1.63 0.0007 10465215 Sssca1 156.9 21.8 255.6 14.9 1.63 0.0121 10470042 Fut7 91.1 7.5 148.3 30.8 1.63 0.0446 10542959 Bet1 214.9 51.7 349.9 23.4 1.63 0.0445 10407985 Gpr141 87.9 10.7 143.0 14.0 1.63 0.0148 10526487 Alkbh4 98.3 11.7 159.8 6.0 1.63 0.0070 10543031 Slc25a13 169.5 24.2 275.6 5.2 1.63 0.0101 10451248 Tjap1 105.4 4.7 171.2 9.5 1.63 0.0017 10385375 Thg1l 117.4 18.1 190.8 6.1 1.62 0.0131 10477966 Manbal 280.6 25.7 455.8 92.3 1.62 0.0440 10459089 Ndst1 264.9 22.7 430.3 14.7 1.62 0.0030 10599207 Slc25a43 149.2 12.9 242.3 33.7 1.62 0.0193 10471337 Pomt1 116.2 8.5 188.6 33.5 1.62 0.0307 10453233 Slc8a1 173.5 19.7 281.5 44.3 1.62 0.0296 10583508 Mrpl4 263.2 17.4 427.1 57.7 1.62 0.0158 10481845 Fam125b 151.2 7.0 245.2 17.8 1.62 0.0031 10576034 Irf8 354.8 5.0 575.4 35.5 1.62 0.0014 10441565 Rps6ka2 217.2 14.9 352.1 6.2 1.62 0.0014 10481654 Fpgs 127.1 16.3 206.0 1.5 1.62 0.0074 10551865 Alkbh6 164.4 9.4 266.4 3.2 1.62 0.0008 10569771 Mcoln1 606.4 41.2 982.6 147.7 1.62 0.0205 10509858 Sdhb 306.1 26.8 495.8 103.8 1.62 0.0473 10579532 Bst2 249.7 17.6 404.4 22.0 1.62 0.0031 10518372 Miip 179.8 14.8 291.1 22.6 1.62 0.0063 10558227 Acadsb 137.5 20.8 222.4 39.6 1.62 0.0468 10526754 Ap4m1 188.3 19.2 304.6 11.6 1.62 0.0050 10598956 Araf 256.6 10.5 414.9 26.6 1.62 0.0022 10500183 Adamtsl4 177.1 18.8 286.3 40.8 1.62 0.0238 10536297 Ppp1r9a 135.6 15.3 219.1 41.3 1.62 0.0427 10404061 Hist1h2bb 127.6 17.0 206.2 9.9 1.62 0.0106 10572357 Cope 708.3 44.5 1143.2 123.3 1.61 0.0094 10582241 Zcchc14 152.2 9.6 245.5 37.0 1.61 0.0206 10403604 Lyst 624.5 84.2 1006.5 51.1 1.61 0.0113 10428328 Slc25a32 169.0 18.1 272.4 52.8 1.61 0.0443 10424340 Ndufb9 268.8 26.8 433.0 14.0 1.61 0.0045 10355528 Tns1 303.5 33.8 488.6 90.9 1.61 0.0418 10541049 March8 348.3 49.8 560.4 9.5 1.61 0.0109 10385818 Uqcrq 260.4 26.1 418.8 26.6 1.61 0.0071 10442643 Nme3 131.5 12.8 211.4 9.1 1.61 0.0050 10607933 Hccs 534.5 45.7 859.0 47.6 1.61 0.0046 10567964 Cln3 710.9 77.6 1142.4 90.3 1.61 0.0104 10498058 Ndufc1 258.3 57.1 415.1 18.0 1.61 0.0370 10495343 Wdr47 149.2 2.6 239.7 9.0 1.61 0.0004 10502224 Sgms2 280.7 21.8 451.0 8.3 1.61 0.0021 10603289 Clcn5 225.1 19.5 361.5 55.0 1.61 0.0246 10573261 Asf1b 343.0 14.3 550.6 39.2 1.61 0.0030 10359034 Qsox1 719.4 7.3 1155.0 35.6 1.61 0.0002 10557439 Ccdc101 129.8 9.7 208.4 23.8 1.61 0.0122 10357535 Pfkfb2 179.5 19.4 288.1 21.5 1.60 0.0096 10417130 Ubac2 329.6 28.2 528.9 46.5 1.60 0.0086 10572290 Nr2c2ap 214.6 11.5 344.1 5.9 1.60 0.0008 10587988 Gk5 112.9 17.3 181.0 26.9 1.60 0.0382 10461614 Ms4a6c 356.6 53.0 571.5 76.3 1.60 0.0318 10402648 Brp44l 365.2 51.8 585.2 79.1 1.60 0.0305 10500034 Psmb4 475.1 41.3 761.0 139.9 1.60 0.0373 10591735 Elof1 463.1 67.3 741.5 91.2 1.60 0.0279 10534660 Ap1s1 469.1 31.1 750.8 131.4 1.60 0.0308 10588522 Rrp9 174.0 12.0 278.1 26.3 1.60 0.0080 10544171 Slc37a3 360.5 40.6 576.2 102.7 1.60 0.0401 10506668 Yipf1 226.0 35.8 361.2 4.8 1.60 0.0150 10386427 Flcn 545.4 11.7 871.6 30.1 1.60 0.0004 10368575 Gm3258 336.6 46.5 537.9 3.6 1.60 0.0102 10517373 Rcan3 161.2 9.5 257.6 22.3 1.60 0.0059 10529445 Lrpap1 408.8 49.9 652.0 58.6 1.59 0.0151 10537728 Casp2 239.2 14.8 381.3 37.6 1.59 0.0082 10546137 Abtb1 161.8 21.0 257.7 2.6 1.59 0.0089 10380871 Stard3 416.8 40.2 663.6 39.2 1.59 0.0066 10445496 Yipf3 288.5 8.2 458.9 34.6 1.59 0.0030 10541683 C1rb 178.2 19.6 283.4 20.5 1.59 0.0103 10481164 Slc2a6 142.2 4.6 226.1 7.7 1.59 0.0006 10525473 Tmem120b 227.9 29.6 362.2 63.8 1.59 0.0445 10456699 Acaa2 517.6 36.7 822.2 92.0 1.59 0.0120 10560983 Dedd2 182.8 1.4 290.4 17.2 1.59 0.0013 10563323 Nucb1 536.0 45.0 850.9 101.4 1.59 0.0155 10450145 Psmb9 349.4 32.9 554.5 2.9 1.59 0.0036 10517883 Necap2 812.4 50.8 1288.1 168.5 1.59 0.0160 10596318 Nudt16 152.7 17.8 242.0 31.7 1.59 0.0248 10344713 Ahcy 205.1 4.9 325.0 46.5 1.58 0.0169 10359422 Prdx6 304.7 37.9 482.6 86.3 1.58 0.0450 10594248 Rplp1 4760.1 355.3 7539.2 403.3 1.58 0.0038 10430302 Csf2rb2 1024.6 29.8 1622.2 29.4 1.58 0.0002 10373093 Dtx3 244.1 28.7 386.4 31.3 1.58 0.0133 10373367 Coq10a 288.5 27.6 456.4 56.9 1.58 0.0191 10499378 Sema4a 947.1 36.6 1497.7 13.4 1.58 0.0003 10387525 Mpdu1 368.3 45.0 582.0 44.5 1.58 0.0136 10559516 Rdh13 171.1 2.2 270.2 10.0 1.58 0.0004 10498117 Rpl29 1699.0 97.0 2683.5 520.4 1.58 0.0403 10404965 Rnf144b 351.4 49.5 554.9 75.1 1.58 0.0329 10443949 Adamts10 203.5 32.6 321.1 15.7 1.58 0.0196 10577048 Ankrd10 159.8 9.6 252.0 2.4 1.58 0.0010 10518774 Park7 578.3 54.7 912.1 65.0 1.58 0.0082 10555671 Pgap2 436.3 30.9 688.0 86.7 1.58 0.0161 10404067 Hist1h4b 1162.2 197.9 1831.1 93.9 1.58 0.0232 10596533 Tex264 371.6 20.2 584.3 28.2 1.57 0.0021 10505270 Slc31a2 612.1 41.3 961.9 20.7 1.57 0.0017 10370914 Fam108a 168.5 10.2 264.7 1.5 1.57 0.0011 10539907 Tpra1 247.9 18.1 389.2 49.0 1.57 0.0167 10373890 Tbc1d10a 171.6 15.4 269.4 11.6 1.57 0.0049 10450103 H2-Ke6 204.1 20.4 320.4 41.2 1.57 0.0220 10596137 Srprb 268.7 20.4 421.4 3.1 1.57 0.0021 10424126 Depdc6 307.7 15.7 482.0 33.9 1.57 0.0038 10359713 Sft2d2 425.0 48.7 665.5 4.7 1.57 0.0070 10419691 Mettl3 306.7 26.4 480.1 4.5 1.57 0.0032 10362499 Frk 82.4 10.0 128.9 6.8 1.57 0.0110 10453216 Thumpd2 78.1 2.7 122.2 1.0 1.57 0.0002 10489553 Acot8 117.9 8.4 184.4 5.8 1.56 0.0025 10447317 Epas1 238.0 50.9 372.1 3.9 1.56 0.0387 10517689 Pqlc2 116.3 9.3 181.7 8.9 1.56 0.0043 10406026 Mrpl36 307.9 61.7 481.2 38.7 1.56 0.0411 10497001 Cryz 138.8 14.5 216.9 21.2 1.56 0.0152 10460285 Nudt8 148.3 6.9 231.5 5.0 1.56 0.0007 10573451 Syce2 124.7 10.2 194.6 8.0 1.56 0.0040 10564507 Arrdc4 810.8 50.6 1265.4 134.0 1.56 0.0108 10607539 Mbtps2 286.5 11.4 447.1 50.5 1.56 0.0104 10412054 Ndufaf2 130.3 10.1 203.3 40.8 1.56 0.0492 10511175 Aurkaip1 515.0 58.0 803.3 143.4 1.56 0.0453 10429391 Slc45a4 152.3 8.4 237.4 18.2 1.56 0.0051 10451458 Cnpy3 407.7 28.9 635.4 90.3 1.56 0.0223 10406407 Arrdc3 320.6 65.5 499.5 33.5 1.56 0.0411 10447594 Dynlt1 1036.5 50.2 1614.7 55.0 1.56 0.0012 10474836 Ivd 206.3 13.9 321.2 30.0 1.56 0.0089 10430618 Dnalc4 161.6 13.8 251.4 7.0 1.56 0.0038 10563130 Aldh16a1 182.2 11.4 283.3 15.0 1.56 0.0032 10583586 Slc44a2 358.2 10.6 556.8 48.7 1.55 0.0051 10519857 Hgf 154.3 16.6 239.8 21.3 1.55 0.0144 10387757 Rai12 309.9 53.4 481.6 2.3 1.55 0.0229 10389099 Rad51l3 165.4 11.8 256.9 5.8 1.55 0.0022 10476301 Smox 159.0 17.1 247.0 26.6 1.55 0.0189 10582310 Mvd 293.7 56.4 456.1 33.4 1.55 0.0377 10450646 Rbx1 526.0 111.4 816.7 43.5 1.55 0.0432 10353438 Tram2 121.6 18.4 188.6 15.7 1.55 0.0249 10532926 Acads 531.0 68.6 823.5 53.6 1.55 0.0154 10398717 Trmt61a 94.9 2.5 147.1 1.3 1.55 0.0001 10426157 Trabd 182.5 21.0 282.8 19.6 1.55 0.0128 10354207 Creg2 80.7 4.7 124.8 2.1 1.55 0.0012 10534966 Zfp113 131.6 6.1 203.6 18.4 1.55 0.0067 10373594 Bloc1s1 395.6 54.1 611.6 91.8 1.55 0.0416 10554895 Crebzf 235.1 15.0 362.6 19.2 1.54 0.0035 10419674 Snord8 258.9 29.1 399.1 23.1 1.54 0.0111 10551169 B3gnt8 133.4 11.1 205.7 21.0 1.54 0.0136 10529895 Qdpr 820.9 72.6 1265.3 53.7 1.54 0.0053 10592114 Foxred1 228.5 16.6 352.0 23.1 1.54 0.0057 10563191 Trpm4 100.9 8.9 155.3 11.4 1.54 0.0090 10600357 Taz 292.4 3.7 450.0 47.8 1.54 0.0084 10358894 Sord 638.1 34.9 981.9 26.2 1.54 0.0014 10585932 Pkm2 1179.7 93.8 1815.0 292.8 1.54 0.0331 10510624 Klhl21 165.5 8.3 254.6 13.1 1.54 0.0024 10479639 Dnajc5 664.4 30.7 1021.7 46.3 1.54 0.0018 10392701 Slc39a11 261.4 21.7 402.0 56.2 1.54 0.0252 10383032 Engase 153.9 11.0 236.6 0.6 1.54 0.0021 10485654 Rpl10 6606.3 631.2 10149.7 510.6 1.54 0.0073 10524034 Idua 274.7 10.8 422.0 46.3 1.54 0.0105 10380699 Copz2 180.2 20.5 276.8 36.6 1.54 0.0293 10365971 Btg1 2398.6 164.2 3684.1 247.4 1.54 0.0056 10568247 Zfp688 120.6 8.4 185.2 15.3 1.54 0.0080 10369989 Ddt 122.4 13.1 187.9 1.1 1.54 0.0068 10546079 Cnbp 1135.2 186.8 1742.7 100.5 1.54 0.0266 10355554 Aamp 590.3 48.2 905.8 159.3 1.53 0.0408 10543080 Rnps1 451.5 28.1 692.7 89.2 1.53 0.0184 10449225 Decr2 260.8 33.3 400.1 60.7 1.53 0.0412 10465783 Tmem179b 721.0 73.1 1106.1 14.5 1.53 0.0060 10560043 Zfp329 101.4 9.0 155.6 5.3 1.53 0.0051 10386070 Atox1 612.2 34.1 938.8 75.8 1.53 0.0062 10464932 Klc2 133.7 8.6 205.0 22.3 1.53 0.0129 10518570 Pgd 1709.9 73.7 2620.8 323.5 1.53 0.0147 10430743 Gm8580 1411.9 91.8 2163.2 373.7 1.53 0.0367 10449581 Mtch1 668.1 50.8 1022.9 108.3 1.53 0.0139 10369541 Hk1 110.9 13.2 169.4 9.8 1.53 0.0132 10448380 Tceb2 1208.7 106.4 1846.8 40.6 1.53 0.0044 10379204 Poldip2 248.7 36.0 379.9 21.7 1.53 0.0205 10502050 Alpk1 213.9 42.5 326.7 22.9 1.53 0.0448 10600390 Gdi1 743.4 126.4 1135.2 49.6 1.53 0.0278 10584271 Tmem218 90.9 5.4 138.7 15.0 1.53 0.0125 10490690 Uckl1 242.7 9.2 370.4 16.3 1.53 0.0014 10584741 Slc37a4 155.7 9.3 237.5 39.2 1.53 0.0329 10367544 Ctdsp2 428.9 63.0 654.2 62.9 1.53 0.0295 10465625 Otub1 365.6 38.1 557.7 89.2 1.53 0.0396 10398085 Glrx5 296.1 11.0 451.6 15.9 1.52 0.0009 10563178 Cd37 292.3 12.6 445.8 32.5 1.52 0.0043 10488020 Tmx4 373.9 18.5 570.1 24.1 1.52 0.0019 10581271 Zdhhc1 193.5 15.0 294.8 40.0 1.52 0.0239 10375343 Rnf145 144.5 7.7 220.2 16.9 1.52 0.0057 10458314 Tmem173 666.0 55.8 1014.3 35.6 1.52 0.0047 10522589 Srd5a3 678.4 71.2 1033.3 39.6 1.52 0.0084 10467493 Tctn3 182.5 12.7 277.8 11.4 1.52 0.0034 10364287 Sumo3 400.2 52.6 609.3 54.2 1.52 0.0230 10362359 Pebp1 431.1 60.1 656.3 77.2 1.52 0.0338 10505982 Fggy 107.5 6.1 163.7 18.1 1.52 0.0130 10375880 Nhp2 347.1 46.9 528.2 3.8 1.52 0.0140 10351738 Pex19 217.3 11.4 330.6 23.8 1.52 0.0049 10579341 Mpv17l2 613.0 33.7 932.4 21.3 1.52 0.0014 10560063 Chmp2a 977.4 108.9 1485.8 125.7 1.52 0.0167 10386518 Atpaf2 159.6 22.3 242.6 22.6 1.52 0.0269 10408162 Zfp322a 86.6 16.9 131.6 11.1 1.52 0.0479 10550332 Slc1a5 439.7 25.8 667.6 59.2 1.52 0.0084 10561247 Shkbp1 238.7 22.8 362.2 6.3 1.52 0.0057 10479887 Sec61a2 136.1 16.3 206.5 13.1 1.52 0.0151 10379215 Ift20 377.7 32.1 572.9 42.3 1.52 0.0094 10509542 Ddost 908.0 64.4 1377.0 93.1 1.52 0.0064 10603478 Tbc1d25 139.0 10.6 210.8 34.9 1.52 0.0372 10352306 Pycr2 170.5 12.7 258.3 23.2 1.52 0.0108 10390258 Snx11 221.1 13.9 335.0 28.7 1.52 0.0084 10582129 Taf1c 158.4 2.3 240.0 27.6 1.52 0.0114 10596857 Apeh 314.8 21.6 476.8 40.0 1.51 0.0088 10459723 Elac1 138.5 2.4 209.8 25.2 1.51 0.0130 10597833 Sec22c 116.3 4.7 176.0 21.6 1.51 0.0152 10515385 Urod 218.4 13.8 330.5 22.4 1.51 0.0056 10354807 Kctd18 118.5 11.1 179.3 8.8 1.51 0.0077 10565057 Wdr73 101.4 17.2 153.4 14.3 1.51 0.0395 10529661 Zfp509 112.2 10.4 169.7 7.8 1.51 0.0072 10486112 Bmf 346.5 24.3 523.9 57.0 1.51 0.0149 10412394 Nnt 351.7 20.7 531.5 4.5 1.51 0.0014 10491406 Ndufb5 550.5 95.6 831.7 14.3 1.51 0.0294 10475630 Galk2 188.4 20.1 284.5 19.7 1.51 0.0134 10373569 Rpsa 1876.8 95.1 2833.1 238.6 1.51 0.0070 10396640 Akap5 438.1 19.3 661.3 106.9 1.51 0.0312 10364072 Ggt5 84.5 5.0 127.5 17.8 1.51 0.0235 10384092 Nudcd3 288.3 21.6 434.9 21.0 1.51 0.0049 10598389 Wdr45 209.2 16.8 315.5 34.0 1.51 0.0166 10463112 Ccnj 83.2 6.5 125.4 0.6 1.51 0.0032 10372069 Socs2 127.0 1.3 191.5 1.4 1.51 0.0000 10563583 Saal1 96.0 4.2 144.7 12.8 1.51 0.0072 10445688 Ccnd3 262.4 24.1 395.5 48.6 1.51 0.0237 10477100 Gm14165 1107.1 66.9 1668.7 92.4 1.51 0.0040 10449699 Wdr4 102.8 3.2 154.9 21.6 1.51 0.0207 10598482 Timm17b 219.0 13.0 329.9 55.9 1.51 0.0373 10409053 Zfp169 132.9 9.9 200.3 7.9 1.51 0.0041 10380129 Supt4h1 560.6 40.5 844.5 6.3 1.51 0.0026 10514347 Cdkn2b 104.1 5.2 156.8 6.5 1.51 0.0020 10596810 Rbm6 109.5 7.0 164.9 16.2 1.51 0.0116 10583847 Bbs9 226.0 12.5 340.3 4.7 1.51 0.0013 10576335 Def8 306.8 24.0 461.9 10.1 1.51 0.0036 10601326 Uprt 260.3 24.6 391.9 10.4 1.51 0.0063 10587503 Sh3bgrl2 542.6 47.1 816.7 29.4 1.51 0.0056 10436941 Mrps6 360.4 64.4 542.5 26.4 1.51 0.0356 10562073 Rbm42 329.0 55.0 495.2 58.0 1.51 0.0475 10589196 Uqcrc1 891.2 82.5 1340.7 58.0 1.50 0.0073 10468916 Fam171a1 83.3 4.0 125.4 0.9 1.50 0.0008 10434998 Ncbp2 211.5 19.0 318.1 20.1 1.50 0.0092 10484431 Txndc14 413.4 58.4 621.4 57.3 1.50 0.0294 10345203 Paox 167.3 14.3 251.5 31.6 1.50 0.0238 10471525 Ptrh1 137.0 8.7 205.9 15.5 1.50 0.0070 10383532 Narf 175.9 17.7 264.3 38.1 1.50 0.0347 10561712 Spint2 146.8 11.7 220.5 30.7 1.50 0.0278 10552433 Zfp658 84.0 9.4 126.1 2.3 1.50 0.0097 10568361 Yipf5 236.2 29.5 354.7 11.4 1.50 0.0138 10409322 Thoc3 254.3 21.2 381.9 39.8 1.50 0.0167 10393341 Rhbdf2 403.7 20.7 606.0 0.9 1.50 0.0010 10393309 Prpsap1 317.9 29.6 476.9 28.6 1.50 0.0095 10382425 Gprc5c 106.4 5.2 159.6 13.9 1.50 0.0077 10556820 Tmem159 268.3 48.9 402.2 9.8 1.50 0.0358 10352092 Zfp238 134.5 17.9 201.6 2.5 1.50 0.0153 10487622 Snrpb 593.4 54.6 889.3 31.2 1.50 0.0067 10435617 Rabl3 162.7 23.3 243.8 3.0 1.50 0.0188 10424810 Gpaa1 329.2 26.3 492.8 43.7 1.50 0.0123 10389581 Ypel2 122.7 10.6 183.7 15.2 1.50 0.0123 10360003 Dusp12 110.3 3.0 165.1 25.6 1.50 0.0278 10567838 Spns1 813.7 36.8 1217.8 33.8 1.50 0.0011 10515844 Zfp691 107.1 9.6 160.2 12.5 1.50 0.0120 10500218 Tars2 259.2 12.0 387.7 10.2 1.50 0.0012 10347521 Zfand2b 151.4 11.6 226.4 2.9 1.50 0.0033 10533095 Fbxw8 247.3 15.9 369.7 15.4 1.50 0.0034 10361152 Gstp2 189.6 11.9 283.4 27.1 1.49 0.0114 10471464 St6galnac6 117.9 4.0 176.2 3.3 1.49 0.0005 10458044 Osgep 314.6 43.0 470.0 42.2 1.49 0.0283 10573461 Dnase2a 520.8 19.9 777.8 1.7 1.49 0.0004 10446013 Mpnd 218.9 23.5 326.7 7.0 1.49 0.0091 10595466 Pgm3 140.1 19.7 209.1 11.4 1.49 0.0223 10464070 Vti1a 212.0 5.4 316.4 2.4 1.49 0.0001 10523451 Anxa3 360.5 28.9 537.8 14.0 1.49 0.0044 10475229 Stard9 127.0 10.0 189.5 20.1 1.49 0.0171 10560630 Tomm40 268.8 18.2 400.9 27.3 1.49 0.0069 10532216 Dgkq 106.3 4.5 158.5 20.1 1.49 0.0183 10387492 Wrap53 138.6 6.0 206.6 2.4 1.49 0.0007 10510708 Icmt 150.9 3.8 225.0 0.4 1.49 0.0001 10515528 Dph2 82.1 2.9 122.3 23.0 1.49 0.0469 10460726 Fau 1535.1 150.3 2288.2 116.3 1.49 0.0097 10448089 Oaz1 1549.2 214.6 2307.7 76.5 1.49 0.0193 10488912 Edem2 325.8 22.7 485.3 31.8 1.49 0.0068 10542872 Rps4y2 229.0 33.5 341.0 5.8 1.49 0.0210 10377473 Aloxe3 135.8 4.6 202.3 7.7 1.49 0.0011 10404874 Mylip 554.8 16.7 826.1 68.9 1.49 0.0058 10536898 Irf5 400.5 19.5 596.2 9.9 1.49 0.0011 10513362 Gm12528 201.7 9.6 300.2 16.7 1.49 0.0032 10381402 Rpl27 1190.8 95.1 1771.4 271.3 1.49 0.0358 10377508 Trappc1 438.2 78.6 651.7 14.4 1.49 0.0364 10502205 Hadh 693.4 91.1 1031.0 31.9 1.49 0.0170 10416199 Entpd4 229.9 4.6 341.8 35.4 1.49 0.0097 10351404 Tmco1 311.9 39.7 463.6 41.6 1.49 0.0259 10468881 Zfp826 145.8 17.6 216.8 21.3 1.49 0.0260 10514275 Ptplad2 378.5 38.7 562.7 25.2 1.49 0.0102 10561178 Rab4b 309.5 42.4 460.1 38.7 1.49 0.0280 10574149 Nlrc5 115.1 14.4 171.1 12.6 1.49 0.0213 10510391 Srm 380.8 28.1 565.7 35.1 1.49 0.0070 10607910 Msl3 516.1 28.9 766.5 1.4 1.49 0.0014 10452485 Rab31 919.6 119.0 1365.4 85.6 1.48 0.0207 10547830 Tpi1 749.2 108.1 1112.4 16.3 1.48 0.0207 10574027 Mt1 2027.2 85.0 3009.4 468.2 1.48 0.0308 10463517 Pprc1 193.4 13.2 287.0 21.3 1.48 0.0082 10596465 Acy1 233.7 36.4 346.9 16.2 1.48 0.0285 10407803 Gpr137b 1175.0 93.5 1743.7 244.0 1.48 0.0301 10374430 Wdr92 109.4 10.7 162.3 3.0 1.48 0.0075 10430020 Vps28 1006.8 68.6 1492.8 107.7 1.48 0.0079 10535231 Ttyh3 504.6 65.1 748.1 103.0 1.48 0.0443 10590182 Exog 87.4 3.2 129.5 0.4 1.48 0.0004 10441038 Hlcs 102.5 6.9 151.9 3.8 1.48 0.0029 10431486 Sbf1 355.0 40.5 526.0 12.3 1.48 0.0116 10496494 Tspan5 492.6 75.5 729.8 5.8 1.48 0.0245 10464659 Rad9 266.5 18.3 394.8 16.7 1.48 0.0042 10425257 Polr2f 308.5 37.6 456.9 5.5 1.48 0.0134 10544487 Tpk1 194.7 11.7 288.3 12.8 1.48 0.0034 10512308 Sigmar1 549.1 61.3 812.9 18.2 1.48 0.0110 10565072 Sec11a 1205.2 194.9 1782.9 67.0 1.48 0.0307 10566502 Arfip2 191.3 8.0 282.9 9.8 1.48 0.0014 10361509 Syne1 444.1 71.0 656.5 9.3 1.48 0.0281 10470775 Cercam 105.4 13.8 155.8 11.0 1.48 0.0238 10449051 Stub1 378.7 27.5 559.6 40.8 1.48 0.0089 10546346 Chchd4 130.6 12.4 192.9 11.1 1.48 0.0107 10490212 Ctsz 4374.0 225.1 6462.4 52.9 1.48 0.0012 10600377 Atp6ap1 2390.1 169.8 3530.7 435.0 1.48 0.0224 10381250 Tubg1 226.4 9.0 334.3 11.4 1.48 0.0012 10364593 Cnn2 165.0 14.3 243.7 14.3 1.48 0.0092 10532802 Alkbh2 158.9 14.9 234.4 20.5 1.48 0.0166 10369379 Slc29a3 269.7 19.0 398.0 24.0 1.48 0.0066 10424833 Maf1 399.3 7.4 589.1 7.3 1.48 0.0001 10351574 Dedd 228.8 16.6 337.5 8.4 1.48 0.0037 10382271 Arsg 204.6 15.8 301.8 11.7 1.48 0.0053 10574204 Arl2bp 287.0 7.8 423.3 5.0 1.47 0.0002 10409204 Gm10784 304.3 44.5 448.7 23.3 1.47 0.0265 10423963 Eny2 192.2 21.9 283.3 16.3 1.47 0.0160 10359826 Uqcr 261.7 30.5 385.8 15.9 1.47 0.0144 10424804 Exosc4 102.8 7.8 151.6 18.3 1.47 0.0227 10527455 Cpsf4 186.2 7.9 274.4 21.6 1.47 0.0063 10443470 Rab44 549.1 65.0 809.1 33.0 1.47 0.0149 10418766 Ankrd28 104.2 12.3 153.6 1.6 1.47 0.0127 10472195 Nudt15 90.8 9.7 133.7 15.5 1.47 0.0291 10486564 Cdan1 130.9 7.3 192.7 11.7 1.47 0.0048 10363903 Hbs1l 304.9 33.7 448.9 39.2 1.47 0.0214 10382106 Gm885 754.7 77.9 1111.0 162.6 1.47 0.0412 10514732 Slc35d1 95.0 5.8 139.8 2.8 1.47 0.0022 10471655 Gsn 541.6 26.0 797.2 113.7 1.47 0.0270 10438232 Dgcr2 344.4 41.2 507.0 28.1 1.47 0.0176 10539143 Retsat 112.6 10.0 165.7 8.2 1.47 0.0086 10494460 Pex11b 132.5 16.3 194.9 26.9 1.47 0.0443 10356859 Dtymk 188.1 11.6 276.7 1.6 1.47 0.0020 10432573 Slc11a2 152.5 16.0 224.3 33.0 1.47 0.0424 10579508 Ano8 171.8 6.1 252.7 30.4 1.47 0.0166 10418720 Mettl6 293.5 16.7 431.4 5.6 1.47 0.0017 10497199 Tmem189 239.7 26.6 352.3 6.1 1.47 0.0112 10585091 Nhp2l1 1091.8 140.9 1603.3 44.2 1.47 0.0177 10355037 Wdr12 106.4 16.0 156.3 5.6 1.47 0.0269 10573203 Gipc1 285.2 16.9 418.8 39.0 1.47 0.0116 10370559 Mier2 119.4 7.0 175.2 7.2 1.47 0.0033 10569656 Tpcn2 316.8 23.1 465.0 55.0 1.47 0.0219 10357280 Insig2 243.0 40.6 356.7 23.7 1.47 0.0403 10430510 Tmem184b 658.4 32.8 965.7 8.3 1.47 0.0011 10571162 Eif4ebp1 306.5 33.8 449.4 66.4 1.47 0.0453 10532857 Gltp 1221.2 137.6 1789.9 67.6 1.47 0.0135 10592237 Ei24 383.7 49.8 562.3 27.1 1.47 0.0206 10388241 Ctns 489.7 31.1 717.6 12.3 1.47 0.0025 10363563 Slc25a16 237.1 23.4 347.3 51.0 1.47 0.0414 10573566 Dhps 160.9 13.9 235.7 38.7 1.46 0.0469 10550597 Fbxo46 163.9 13.0 240.1 12.1 1.46 0.0072 10466521 Gcnt1 235.0 7.3 344.0 60.9 1.46 0.0440 10425267 Pick1 97.3 5.3 142.3 8.9 1.46 0.0052 10540790 Vhl 158.6 13.8 231.9 16.0 1.46 0.0118 10525374 Pptc7 226.3 12.8 330.9 18.6 1.46 0.0046 10503915 Chchd2 1434.4 160.8 2097.5 147.1 1.46 0.0188 10406141 Brd9 259.3 17.8 379.1 23.9 1.46 0.0073 10380560 Zfp652 186.6 14.2 272.9 11.0 1.46 0.0057 10568785 Bnip3 94.0 14.3 137.4 11.4 1.46 0.0381 10574944 Dus2l 108.5 15.9 158.6 13.1 1.46 0.0353 10581311 Acd 91.5 2.5 133.8 6.5 1.46 0.0017 10543134 Ndufa4 1219.0 149.4 1781.2 141.6 1.46 0.0247 10606088 Hdac8 97.2 12.5 141.9 13.7 1.46 0.0322 10465005 Banf1 701.0 32.1 1023.7 25.4 1.46 0.0013 10420131 Rabggta 200.8 20.3 293.2 39.0 1.46 0.0361 10363522 Tysnd1 244.2 25.8 356.2 28.4 1.46 0.0193 10374106 Ykt6 324.0 29.4 472.6 27.0 1.46 0.0108 10445442 Gtpbp2 254.2 23.7 370.7 7.2 1.46 0.0076 10558936 Efcab4a 96.9 8.4 141.4 4.1 1.46 0.0067 10463229 Zfyve27 308.5 6.8 449.6 22.3 1.46 0.0016 10605319 Ubl4 355.4 20.3 517.9 48.0 1.46 0.0118 10480699 Dpp7 579.3 21.1 843.6 15.9 1.46 0.0007 10569958 Ccl25 94.3 10.1 137.3 20.2 1.46 0.0456 10427323 Copz1 952.8 115.4 1386.8 169.7 1.46 0.0396 10471457 St6galnac4 144.5 16.0 210.4 5.9 1.46 0.0128 10585509 Fbxo22 542.0 22.2 788.7 30.9 1.46 0.0018 10410341 Zfp87 181.9 29.4 264.6 14.2 1.45 0.0377 10396671 Plekhg3 164.0 11.9 238.5 31.9 1.45 0.0294 10497390 Armc1 248.8 23.1 361.8 36.1 1.45 0.0218 10347508 Fam134a 370.4 49.3 538.4 32.1 1.45 0.0253 10508074 Csf3r 153.6 16.0 223.3 3.8 1.45 0.0104 10541112 Hnrnpf 176.4 23.5 256.5 25.9 1.45 0.0367 10393955 Dus1l 176.7 20.1 256.8 7.0 1.45 0.0139 10584200 Rpusd4 186.4 4.9 270.9 14.6 1.45 0.0022 10473125 Itga4 990.5 30.4 1439.0 153.5 1.45 0.0128 10551803 Zfp568 151.6 9.8 220.2 12.7 1.45 0.0062 10528598 Fastk 212.1 5.4 308.0 48.1 1.45 0.0334 10585759 Edc3 268.9 6.7 390.4 37.2 1.45 0.0092 10540923 Mkrn2 217.8 5.9 316.1 43.2 1.45 0.0240 10514298 Mrpl48 278.6 30.8 404.2 9.3 1.45 0.0128 10401968 Galc 186.0 28.2 269.8 19.1 1.45 0.0369 10507218 Mknk1 884.3 35.2 1282.8 42.9 1.45 0.0014 10377851 Psmb6 630.6 39.0 914.8 67.3 1.45 0.0085 10426292 Alg10b 376.7 9.4 545.9 74.2 1.45 0.0238 10545001 Ppm1k 122.7 9.2 177.8 29.2 1.45 0.0468 10485378 Prr5l 346.6 27.2 502.1 26.8 1.45 0.0081 10518520 Ubiad1 167.4 15.6 242.5 8.9 1.45 0.0093 10549361 Tm7sf3 412.5 33.7 597.5 98.4 1.45 0.0489 10538640 Abcg2 107.6 15.0 155.8 18.4 1.45 0.0473 10358816 Lamc1 96.6 9.5 139.9 6.6 1.45 0.0119 10534679 Trim56 247.9 11.5 358.7 41.9 1.45 0.0185 10574985 Slc7a6 191.1 27.9 276.4 26.5 1.45 0.0422 10481128 Med22 321.6 26.7 465.1 15.5 1.45 0.0068 10374020 Rhbdd3 110.8 5.2 160.3 4.5 1.45 0.0017 10509868 Atp13a2 731.7 47.9 1058.1 141.0 1.45 0.0288 10549497 Fam60a 128.9 20.9 186.4 13.1 1.45 0.0431 10585652 Man2c1 273.4 7.8 395.2 37.9 1.45 0.0099 10465043 Tsga10ip 310.0 5.1 448.1 19.0 1.45 0.0010 10434029 Lztr1 302.4 26.3 437.1 10.4 1.45 0.0070 10511258 Fam132a 88.8 3.7 128.3 16.3 1.44 0.0222 10594631 Aph1b 143.2 13.5 206.9 14.5 1.44 0.0151 10464819 Rbm14 238.6 7.6 344.6 16.3 1.44 0.0020 10604932 Cd99l2 91.9 13.3 132.7 4.7 1.44 0.0281 10570201 Atp11a 282.5 7.2 408.1 35.9 1.44 0.0078 10495873 Ptma 1530.8 12.8 2210.7 351.5 1.44 0.0351 10558872 Tmem80 150.3 5.9 216.9 22.1 1.44 0.0128 10353871 Lman2l 272.7 12.6 393.4 21.9 1.44 0.0039 10433389 Alg1 466.0 35.9 672.1 109.9 1.44 0.0482 10467842 Got1 230.4 20.0 332.3 22.2 1.44 0.0126 10431601 Arsa 254.8 27.6 367.3 0.3 1.44 0.0120 10364239 Slc19a1 147.9 5.0 213.3 0.3 1.44 0.0004 10448441 Amdhd2 331.4 8.5 477.8 15.7 1.44 0.0008 10485340 Itpa 335.5 8.8 483.6 35.4 1.44 0.0049 10550605 Eml2 225.3 15.1 324.7 6.5 1.44 0.0034 10444439 Atf6b 428.3 30.3 617.2 94.8 1.44 0.0411 10353878 Ankrd23 107.0 2.4 154.2 16.6 1.44 0.0133 10372488 Tmem19 198.5 26.8 285.9 22.5 1.44 0.0327 10477808 Romo1 437.7 27.6 630.6 86.4 1.44 0.0308 10405495 B4galt7 147.3 2.2 212.2 1.5 1.44 0.0000 10442629 Spsb3 143.2 12.4 206.2 2.9 1.44 0.0068 10458808 Fem1c 567.6 25.2 817.2 90.9 1.44 0.0167 10419676 Rab2b 103.9 9.8 149.5 15.9 1.44 0.0260 10467859 Cox15 218.8 25.7 315.0 42.4 1.44 0.0468 10358379 Trove2 215.8 10.6 310.5 21.4 1.44 0.0063 10607250 Apex2 117.6 9.0 169.2 9.2 1.44 0.0083 10518385 Mfn2 385.5 31.4 554.5 42.5 1.44 0.0137 10517236 Zfp593 104.1 6.9 149.7 13.4 1.44 0.0136 10405894 Ptdss1 482.9 61.6 694.5 63.9 1.44 0.0339 10353844 Neurl3 105.5 13.0 151.7 6.3 1.44 0.0205 10376358 Sh3bp5l 116.5 7.9 167.5 10.8 1.44 0.0084 10433219 Nat15 837.8 35.3 1204.1 76.9 1.44 0.0048 10569265 Tollip 436.0 11.3 626.5 7.9 1.44 0.0003 10476093 Nop56 490.8 39.0 705.1 102.8 1.44 0.0398 10346224 Tmem194b 95.2 6.5 136.8 19.3 1.44 0.0345 10549700 Suv420h2 447.2 50.8 641.7 68.2 1.44 0.0337 10585721 Scamp2 917.9 79.8 1316.9 29.0 1.43 0.0074 10559694 Sbk2 87.1 8.1 124.9 18.7 1.43 0.0469 10540122 Slc6a6 2439.5 142.7 3497.2 530.5 1.43 0.0385 10579313 Ssbp4 266.7 16.6 382.3 15.3 1.43 0.0044 10414355 Mapk1ip1l 568.9 39.5 815.3 52.1 1.43 0.0088 10522749 Lphn3 261.9 0.8 375.4 29.3 1.43 0.0052 10345183 Cdk10 238.0 4.0 340.9 37.4 1.43 0.0141 10547701 Pex5 191.5 9.8 274.3 22.3 1.43 0.0093 10422776 Phb 434.3 41.1 622.0 40.1 1.43 0.0151 10597377 Fbxl2 105.4 11.9 150.9 2.6 1.43 0.0147 10404597 Fars2 289.2 36.0 414.1 47.1 1.43 0.0419 10445695 Med20 120.7 8.0 172.8 3.3 1.43 0.0035 10408202 Hist1h3f 1520.5 150.9 2176.8 309.1 1.43 0.0452 10472933 Scrn3 125.8 13.2 180.1 1.1 1.43 0.0118 10480760 Traf2 173.9 14.9 248.9 10.8 1.43 0.0093 10428119 Cox6c 879.8 79.8 1259.0 0.2 1.43 0.0078 10424922 Gpr172b 166.3 9.8 237.9 6.7 1.43 0.0031 10402835 Nudt14 143.3 8.2 205.0 9.2 1.43 0.0042 10345777 Il1rl2 501.9 35.3 718.1 23.2 1.43 0.0050 10494957 Ap4b1 202.1 2.5 289.1 17.9 1.43 0.0029 10487629 Idh3b 937.0 71.3 1340.0 87.9 1.43 0.0106 10462091 Klf9 215.9 13.8 308.6 28.3 1.43 0.0144 10562059 Cox6b1 1123.2 83.8 1605.0 184.0 1.43 0.0250 10380524 Slc35b1 384.9 33.4 549.9 43.0 1.43 0.0163 10368577 Rnf217 176.2 29.9 251.7 14.1 1.43 0.0489 10404380 Dusp22 265.8 31.0 379.8 32.1 1.43 0.0284 10412773 Slc4a7 164.2 12.0 234.5 34.6 1.43 0.0406 10552681 Josd2 133.9 12.5 191.3 9.1 1.43 0.0120 10568050 Aldoa 3575.3 263.5 5105.4 115.4 1.43 0.0050 10535034 Zfp68 158.4 6.0 226.2 10.5 1.43 0.0025 10464825 Ccs 101.0 0.6 144.1 25.2 1.43 0.0475 10529041 Preb 722.4 40.8 1030.8 38.0 1.43 0.0035 10363000 Gpx4 1492.0 91.6 2129.0 70.4 1.43 0.0038 10444079 Rgl2 378.7 22.9 540.4 29.9 1.43 0.0061 10470109 Fbxw5 392.2 29.5 559.6 64.2 1.43 0.0254 10460591 Fibp 312.5 35.8 445.8 48.5 1.43 0.0366 10360957 Kctd3 86.7 4.0 123.7 0.3 1.43 0.0011 10450640 Mrps18b 354.8 33.4 505.8 30.0 1.43 0.0144 10579925 Gab1 164.7 26.4 234.8 5.9 1.43 0.0391 10487371 Ciao1 309.0 23.8 440.4 59.4 1.43 0.0354 10429160 St3gal1 289.7 27.3 412.8 18.9 1.43 0.0123 10606315 Taf9b 132.2 18.2 188.4 12.7 1.43 0.0339 10464583 Gstp1 940.8 57.9 1340.8 9.0 1.43 0.0027 10431424 Plxnb2 404.5 51.0 576.4 46.6 1.42 0.0321 10525452 Rnf34 236.1 13.0 336.5 1.0 1.42 0.0019 10438575 Ehhadh 202.7 24.6 288.8 10.1 1.42 0.0203 10551883 Tyrobp 3418.2 509.3 4870.0 447.6 1.42 0.0476 10479063 Rab22a 299.7 15.0 426.9 33.9 1.42 0.0091 10437687 Litaf 975.9 151.2 1390.1 95.5 1.42 0.0438 10463632 Tmem180 280.1 23.4 398.9 17.2 1.42 0.0091 10476252 Cdc25b 341.2 7.2 485.8 13.7 1.42 0.0005 10372583 Rab3ip 95.6 6.3 136.0 17.7 1.42 0.0304 10383245 Rptor 231.2 13.6 329.2 24.4 1.42 0.0094 10477777 Ergic3 541.6 75.8 771.0 5.8 1.42 0.0270 10397561 Adck1 141.3 6.8 201.1 23.5 1.42 0.0210 10427918 Fam105a 1091.7 120.8 1553.0 35.2 1.42 0.0152 10371607 Dram1 762.9 51.6 1085.2 56.4 1.42 0.0070 10422608 Oxct1 329.0 46.7 468.0 12.4 1.42 0.0295 10498795 Zfp114 171.7 11.9 244.3 28.8 1.42 0.0258 10371321 Slc41a2 171.8 18.1 244.4 34.0 1.42 0.0480 10461093 Pla2g16 127.8 7.7 181.7 5.0 1.42 0.0034 10511290 Tnfrsf18 108.0 2.6 153.6 13.7 1.42 0.0090 10433199 Zfp263 166.4 6.6 236.6 20.3 1.42 0.0095 10604633 Cxx1b 230.1 21.6 326.9 3.3 1.42 0.0094 10434758 St6gal1 168.0 16.5 238.6 10.2 1.42 0.0133 10465790 Taf6l 167.6 10.3 238.1 0.3 1.42 0.0028 10565519 Tmem126b 175.2 9.6 248.7 11.3 1.42 0.0042 10416044 Ccdc25 174.3 23.2 247.4 7.4 1.42 0.0259 10429908 Bop1 314.6 15.3 446.4 45.5 1.42 0.0157 10433311 Mgrn1 617.7 44.5 876.6 69.4 1.42 0.0135 10426535 Amigo2 199.0 22.3 282.4 35.3 1.42 0.0443 10550833 Zfp180 156.6 6.4 222.3 7.9 1.42 0.0019 10588826 Ip6k1 276.9 24.9 393.0 29.1 1.42 0.0170 10351563 B4galt3 203.3 3.1 288.4 34.3 1.42 0.0185 10565873 Ppme1 230.9 8.7 327.5 13.4 1.42 0.0021 10603373 Pqbp1 501.4 47.5 711.3 36.0 1.42 0.0136 10414594 Mett11d1 219.5 12.1 311.4 40.2 1.42 0.0281 10464783 Rce1 196.8 14.9 279.1 41.2 1.42 0.0431 10547513 Cecr5 193.4 14.6 274.3 11.7 1.42 0.0075 10499560 Adam15 320.2 43.8 454.2 25.4 1.42 0.0321 10493537 Pbxip1 356.1 10.4 505.0 41.4 1.42 0.0076 10448307 Tnfrsf12a 200.8 7.5 284.8 7.8 1.42 0.0012 10469856 Wdr85 109.0 6.7 154.6 20.7 1.42 0.0321 10499470 Rusc1 191.9 7.1 271.9 13.5 1.42 0.0029 10487871 Cenpb 565.0 34.1 800.4 50.4 1.42 0.0077 10429843 Parp10 139.4 8.3 197.5 10.9 1.42 0.0063 10380551 Phb 442.1 45.1 626.1 31.5 1.42 0.0162 10539592 Smyd5 168.3 9.1 238.3 13.3 1.42 0.0055 10433331 Nudt16l1 304.8 30.0 431.7 60.6 1.42 0.0473 10534570 Orai2 184.8 17.9 261.7 3.9 1.42 0.0108 10382852 Mfsd11 353.9 36.8 501.1 49.2 1.42 0.0300 10376461 Trim11 193.7 8.9 274.3 43.2 1.42 0.0426 10415818 Wdfy2 330.0 22.6 467.2 35.2 1.42 0.0120 10394690 E2f6 159.7 7.2 226.1 3.8 1.42 0.0014 10569886 Trappc5 149.1 9.9 211.0 1.0 1.42 0.0036 10489065 Ndrg3 402.6 18.4 569.8 60.4 1.42 0.0170 10390032 Acsf2 197.7 19.0 279.8 37.6 1.42 0.0433 10462918 Tmem20 237.2 7.9 335.7 40.6 1.42 0.0213 10572613 Mrpl34 145.5 10.3 205.9 27.2 1.41 0.0340 10555235 Arrb1 141.8 1.0 200.6 27.1 1.41 0.0261 10503178 Chd7 313.7 40.6 443.7 31.2 1.41 0.0326 10575867 Mlycd 135.1 15.5 191.1 5.4 1.41 0.0183 10541545 Necap1 225.4 10.5 318.6 27.9 1.41 0.0112 10404731 Tmem14c 949.5 49.5 1342.3 147.7 1.41 0.0198 10347672 Stk11ip 196.6 8.5 277.9 22.3 1.41 0.0089 10544186 Mkrn1 420.0 20.3 593.6 69.7 1.41 0.0222 10460344 Tmem134 367.9 27.3 519.8 55.7 1.41 0.0238 10518927 Kcnab2 562.4 33.2 794.6 113.0 1.41 0.0368 10537410 Tbxas1 1396.8 112.2 1973.4 300.8 1.41 0.0487 10490169 Ppp4r1l 91.9 9.7 129.8 7.3 1.41 0.0190 10555011 Nars2 132.6 16.7 187.3 12.1 1.41 0.0296 10364814 Scamp4 321.0 15.8 453.4 15.9 1.41 0.0027 10425000 Lrrc14 106.3 7.2 150.1 20.2 1.41 0.0348 10588707 Ifrd2 223.3 8.8 315.3 50.4 1.41 0.0436 10553015 Bcat2 248.1 24.1 350.3 13.4 1.41 0.0131 10374364 Akt2 1261.5 104.7 1781.0 10.0 1.41 0.0070 10582275 Slc7a5 517.9 15.6 730.8 120.8 1.41 0.0461 10566358 Trim30 732.7 61.5 1033.7 144.3 1.41 0.0428 10495530 Dph5 146.5 19.0 206.7 17.6 1.41 0.0381 10551971 U2af1l4 229.7 16.1 324.0 14.1 1.41 0.0069 10383423 Anapc11 350.5 16.2 494.4 11.7 1.41 0.0018 10406710 Tbca 1180.6 164.2 1665.3 10.2 1.41 0.0288 10533246 Oas1g 126.8 10.2 178.8 20.8 1.41 0.0298 10513608 Alad 186.4 9.9 262.9 7.5 1.41 0.0028 10419170 Txndc16 191.8 23.4 270.5 8.1 1.41 0.0219 10525718 Arl6ip4 209.9 9.4 296.0 15.6 1.41 0.0041 10402841 Brf1 218.2 12.9 307.6 0.8 1.41 0.0026 10595924 Pik3cb 426.7 48.5 601.5 38.4 1.41 0.0243 10393408 Tmc6 122.7 10.5 172.8 11.9 1.41 0.0154 10438445 Klhl6 459.1 10.5 646.8 62.5 1.41 0.0116 10546113 Sec61a1 1132.7 61.0 1595.9 179.4 1.41 0.0216 10495111 Wdr77 552.1 27.0 777.6 73.6 1.41 0.0141 10446771 Lclat1 220.8 13.8 310.9 23.3 1.41 0.0111 10389858 Nme2 620.4 75.2 873.1 44.3 1.41 0.0252 10548000 Ltbr 293.0 6.9 412.2 13.7 1.41 0.0009 10392983 Slc25a19 103.3 4.3 145.3 0.5 1.41 0.0010 10551696 Rasgrp4 243.7 15.1 342.8 29.1 1.41 0.0137 10584954 Pcsk7 165.5 7.7 232.7 2.4 1.41 0.0014 10461311 Eml3 285.6 4.3 401.5 43.9 1.41 0.0157 10433034 Atf7 502.5 43.9 706.3 74.5 1.41 0.0283 10448765 Mapk8ip3 238.2 35.3 334.7 22.5 1.41 0.0442 10481401 Zer1 125.7 14.7 176.7 17.9 1.41 0.0387 10526250 Abhd11 169.3 13.3 237.9 33.1 1.41 0.0420 10379013 Flot2 486.6 9.6 683.4 10.6 1.40 0.0002 10465427 Rps6ka4 221.1 13.7 310.4 1.2 1.40 0.0032 10545534 Rnf26 299.2 20.8 419.9 43.1 1.40 0.0219 10475965 Polr1b 205.9 3.1 289.0 8.7 1.40 0.0005 10359377 Zbtb37 103.8 14.4 145.7 9.7 1.40 0.0390 10512356 Gm13305 147.7 9.5 207.2 30.7 1.40 0.0435 10384032 Pold2 117.6 3.3 164.9 13.4 1.40 0.0080 10416256 Bin3 416.2 25.7 583.6 25.1 1.40 0.0055 10487359 Itpripl1 264.9 4.4 371.3 26.9 1.40 0.0053 10502732 Prkacb 620.5 36.9 869.6 88.6 1.40 0.0193 10479099 Npepl1 386.9 33.4 542.2 14.0 1.40 0.0093 10364385 Ilvbl 175.3 14.3 245.7 23.7 1.40 0.0234 10551319 Adck4 190.0 23.5 266.2 9.5 1.40 0.0249 10515590 Kdm4a 441.6 3.3 618.7 20.0 1.40 0.0005 10420023 Fam158a 122.9 8.7 172.1 21.3 1.40 0.0320 10465150 Pcnxl3 277.6 14.8 388.8 29.5 1.40 0.0100 10364571 Wdr18 174.4 12.4 244.3 4.2 1.40 0.0052 10427015 Acvr1b 644.3 7.0 902.0 52.7 1.40 0.0028 10554269 Abhd2 540.5 33.4 756.7 42.6 1.40 0.0076 10361897 Ifngr1 1363.1 41.3 1908.3 170.2 1.40 0.0105 10444895 Flot1 184.5 11.6 258.3 4.1 1.40 0.0037 10433597 Snx29 182.2 14.2 255.1 6.1 1.40 0.0071 10505282 Prpf4 224.4 15.7 314.0 24.0 1.40 0.0138 10507539 Elovl1 930.8 92.7 1301.9 101.7 1.40 0.0239 10365116 Dohh 126.3 11.9 176.7 12.7 1.40 0.0200 10579607 B3gnt3 122.1 14.4 170.8 8.7 1.40 0.0252 10352503 Bpnt1 316.9 50.1 443.0 20.2 1.40 0.0476 10596931 Wdr6 114.1 4.2 159.5 17.0 1.40 0.0174 10571114 Erlin2 352.1 35.5 492.0 62.0 1.40 0.0448 10418868 Wdfy4 1200.7 13.6 1677.3 73.6 1.40 0.0013 10371041 Sgta 385.5 3.6 538.4 28.7 1.40 0.0022 10569057 Rnh1 1154.1 105.6 1611.7 194.4 1.40 0.0383 10387871 Pelp1 190.4 4.1 265.7 15.6 1.40 0.0033 10534102 Gusb 894.4 62.8 1248.3 51.4 1.40 0.0073 10524436 Usp30 148.1 19.8 206.7 19.8 1.40 0.0477 10545409 Vamp8 870.4 80.5 1214.3 108.4 1.40 0.0254 10541711 Phb2 760.4 36.1 1060.7 73.3 1.39 0.0078 10439895 Alcam 142.1 16.4 198.3 16.0 1.39 0.0324 10429674 Tsta3 192.0 14.3 267.7 15.3 1.39 0.0108 10532317 Gtpbp6 128.3 11.3 178.9 2.2 1.39 0.0094 10512574 Gba2 129.7 14.0 180.9 6.0 1.39 0.0185 10533529 Camkk2 328.8 13.5 458.3 47.4 1.39 0.0171 10449191 Solh 416.7 41.3 580.8 44.7 1.39 0.0242 10607658 Reps2 131.0 9.5 182.6 14.6 1.39 0.0160 10561854 Tbcb 479.4 51.8 668.1 0.1 1.39 0.0164 10448707 Tbl3 222.3 17.8 309.8 1.3 1.39 0.0071 10607870 Tlr7 756.3 46.5 1053.9 61.6 1.39 0.0082 10386230 Rnf187 590.3 45.7 822.6 49.9 1.39 0.0124 10427369 Pde1b 286.7 46.7 399.5 3.0 1.39 0.0480 10585860 Adpgk 244.8 14.4 341.1 3.7 1.39 0.0031 10430748 Rangap1 323.1 12.6 450.2 8.2 1.39 0.0012 10596664 Cyb561d2 136.9 13.0 190.6 19.2 1.39 0.0311 10470948 Slc39a1 398.2 26.8 554.5 42.3 1.39 0.0136 10526743 Cops6 454.9 30.1 633.3 38.6 1.39 0.0098 10469300 Ankrd16 153.6 8.1 213.8 1.1 1.39 0.0021 10520782 Zfp512 107.5 6.7 149.6 8.9 1.39 0.0086 10511190 Dvl1 215.2 23.8 299.5 2.7 1.39 0.0179 10558707 Ric8 243.8 10.4 339.3 3.4 1.39 0.0012 10497894 Cetn4 181.3 14.3 252.2 15.7 1.39 0.0134 10415293 Rnf31 234.9 5.5 326.6 12.8 1.39 0.0014 10385004 Mare 183.0 6.7 254.5 3.7 1.39 0.0009 10465912 Fen1 160.0 17.6 222.5 17.5 1.39 0.0301 10463945 Dusp5 457.2 14.0 635.4 33.7 1.39 0.0033 10499883 Adrm1 506.9 16.2 704.4 5.6 1.39 0.0005 10458386 Ndufa2 330.8 34.9 459.6 4.8 1.39 0.0160 10367337 Rnf41 229.1 13.0 318.3 7.2 1.39 0.0034 10533386 Sh2b3 267.8 13.5 372.0 41.1 1.39 0.0223 10541695 Lpcat3 1120.5 115.8 1556.6 193.4 1.39 0.0470 10376263 Mfap3 416.9 31.0 579.1 68.8 1.39 0.0326 10376208 Gm2a 1854.4 149.5 2575.0 162.1 1.39 0.0143 10568024 Coro1a 2051.0 106.5 2848.0 342.3 1.39 0.0272 10471108 Gpr107 419.0 40.0 581.7 6.9 1.39 0.0123 10460317 Pitpnm1 514.0 43.1 713.5 23.6 1.39 0.0103 10358982 Mr1 484.0 52.5 671.7 30.6 1.39 0.0213 10530633 Sgcb 221.0 29.0 306.7 22.4 1.39 0.0402 10434191 Txnrd2 131.3 13.4 182.2 1.3 1.39 0.0148 10512847 Alg2 159.3 20.9 221.0 6.3 1.39 0.0303 10501244 Ampd2 229.1 19.6 317.5 12.4 1.39 0.0117 10559436 Mboat7 389.2 40.7 539.3 50.2 1.39 0.0336 10397189 Ptgr2 160.9 25.0 223.0 0.9 1.39 0.0447 10471045 Ppp2r4 389.7 20.8 540.0 24.5 1.39 0.0050 10539472 Nagk 561.3 1.3 777.6 36.0 1.39 0.0015 10462102 Ptar1 202.1 8.8 279.9 36.7 1.39 0.0319 10493409 Scamp3 753.3 66.0 1043.0 41.5 1.38 0.0126 10465366 Zfpl1 122.6 12.4 169.8 10.5 1.38 0.0221 10408246 Hist1h3a 1646.3 122.2 2279.3 318.3 1.38 0.0452 10480570 Arrdc1 282.7 19.8 391.4 9.2 1.38 0.0060 10501143 Ahcyl1 489.7 12.2 678.0 105.6 1.38 0.0445 10348277 Atg16l1 262.2 18.6 362.6 0.8 1.38 0.0054 10580957 Slc38a7 475.7 44.3 657.8 7.6 1.38 0.0120 10565634 Myo7a 614.7 57.4 850.0 65.9 1.38 0.0236 10535213 Snx8 169.5 7.6 234.2 30.6 1.38 0.0322 10490672 Arfrp1 293.9 30.6 406.0 8.2 1.38 0.0169 10504349 Creb3 462.0 44.6 637.9 43.5 1.38 0.0223 10452269 Dennd1c 324.1 39.9 447.4 39.9 1.38 0.0430 10478875 Rnf114 504.9 55.6 697.0 32.5 1.38 0.0234 10488048 Mkks 116.6 3.1 161.0 7.5 1.38 0.0023 10596053 Pccb 299.4 17.4 413.3 14.7 1.38 0.0048 10384123 Ddx56 223.6 25.2 308.5 14.7 1.38 0.0250 10527213 Daglb 443.8 38.5 612.4 54.7 1.38 0.0255 10443221 Uhrf1bp1 150.1 6.3 207.0 10.4 1.38 0.0043 10376314 Cnot8 470.2 53.0 648.5 2.9 1.38 0.0204 10511149 Mrpl20 155.8 14.2 214.8 15.0 1.38 0.0210 10424894 Heatr7a 642.2 22.0 885.0 4.6 1.38 0.0007 10552418 Etfb 981.3 76.2 1351.9 51.5 1.38 0.0098 10557816 Bckdk 477.3 47.4 657.3 34.4 1.38 0.0201 10365518 Nt5dc3 177.2 16.0 243.9 18.7 1.38 0.0230 10528480 Gm6560 1229.1 81.2 1691.7 52.6 1.38 0.0061 10474936 Spint1 907.5 113.6 1249.0 33.2 1.38 0.0289 10437499 Glyr1 809.6 4.2 1114.2 19.7 1.38 0.0001 10572591 Ocel1 115.1 5.0 158.3 7.5 1.38 0.0041 10591947 Acad8 284.2 13.1 390.8 42.6 1.38 0.0224 10595126 Fbxo9 209.3 10.7 287.6 39.1 1.37 0.0382 10393573 Lgals3bp 1340.2 130.9 1841.6 191.1 1.37 0.0374 10404028 Hist1h3g 1664.1 136.3 2286.7 291.5 1.37 0.0431 10478615 Pcif1 321.2 25.7 441.3 36.8 1.37 0.0216 10508382 Ak2 507.4 57.6 697.1 67.4 1.37 0.0423 10533633 Diablo 120.3 5.2 165.2 20.3 1.37 0.0290 10417167 Clybl 164.3 23.6 225.7 6.3 1.37 0.0416 10569203 Chid1 116.8 8.4 160.5 0.6 1.37 0.0060 10438517 Alg3 460.1 24.6 631.9 9.8 1.37 0.0029 10527012 Lfng 514.5 30.9 706.4 44.7 1.37 0.0101 10406598 Serinc5 202.4 13.9 277.7 14.2 1.37 0.0097 10409767 Golm1 487.3 38.0 668.4 64.7 1.37 0.0264 10557528 Kctd13 201.2 20.9 275.9 31.2 1.37 0.0456 10363894 Ipmk 488.9 60.4 670.2 5.1 1.37 0.0277 10594289 Glce 113.8 3.9 156.0 7.4 1.37 0.0032 10429926 Dgat1 417.4 48.3 571.6 51.5 1.37 0.0418 10561306 Pld3 2082.2 156.3 2851.1 102.2 1.37 0.0093 10606102 Phka1 126.1 11.2 172.7 8.2 1.37 0.0158 10390283 Cdk5rap3 272.4 24.2 372.8 47.6 1.37 0.0475 10471201 Abl1 293.7 23.3 402.0 45.0 1.37 0.0347 10363210 Pkib 106.4 5.6 145.7 8.8 1.37 0.0081 10494583 Sec22b 357.9 28.3 489.6 24.9 1.37 0.0131 10572318 Tmem161a 138.7 4.3 189.7 6.5 1.37 0.0017 10391410 Becn1 434.1 27.3 593.6 38.3 1.37 0.0114 10597173 Nradd 101.2 5.2 138.3 9.4 1.37 0.0097 10517081 Gm13213 279.9 15.7 382.5 39.3 1.37 0.0229 10494122 Rfx5 101.4 6.6 138.6 7.9 1.37 0.0105 10449631 Btbd9 374.0 16.6 510.9 36.5 1.37 0.0093 10413826 Oxnad1 93.0 6.0 127.1 12.4 1.37 0.0229 10603453 Wdr13 252.2 11.9 344.2 19.4 1.37 0.0065 10605766 Maged1 128.3 8.8 175.1 8.3 1.36 0.0096 10572786 Ap1m1 495.2 41.3 675.7 15.3 1.36 0.0109 10504606 Aldh1b1 132.6 11.4 180.9 5.7 1.36 0.0126 10500445 Chd1l 150.5 10.8 205.3 7.3 1.36 0.0087 10370471 Agpat3 272.0 23.9 371.1 11.7 1.36 0.0135 10448593 Traf7 365.0 16.7 497.8 19.3 1.36 0.0037 10448842 Telo2 92.0 4.2 125.4 0.9 1.36 0.0018 10368630 Rwdd1 435.4 20.7 593.6 36.2 1.36 0.0076 10360058 Tomm40l 173.4 15.4 236.3 6.7 1.36 0.0135 10444137 Rxrb 225.4 14.8 307.2 28.8 1.36 0.0224 10394609 Rpl36 980.2 70.9 1335.8 119.6 1.36 0.0228 10583920 Eepd1 410.5 28.7 559.4 2.3 1.36 0.0061 10500683 Rangrf 138.5 10.5 188.7 16.7 1.36 0.0236 10515574 St3gal3 218.0 15.8 297.0 8.1 1.36 0.0080 10519504 Sri 1079.4 50.0 1470.5 217.1 1.36 0.0475 10518300 Tnfrsf1b 1737.7 111.7 2367.1 16.8 1.36 0.0049 10433114 Itga5 571.6 54.6 778.5 46.3 1.36 0.0223 10347552 Stk16 262.4 13.1 357.4 26.7 1.36 0.0116 10488575 Psmf1 229.8 16.8 312.9 7.6 1.36 0.0080 10452356 Gpr108 412.7 37.9 561.9 10.1 1.36 0.0139 10578521 Snx25 97.6 10.1 132.9 3.9 1.36 0.0204 10371770 Gas2l3 418.2 38.0 569.1 20.3 1.36 0.0155 10360076 Ndufs2 603.0 73.9 820.3 31.0 1.36 0.0324 10521031 Ywhah 1398.0 66.2 1901.8 114.9 1.36 0.0076 10458784 Pggt1b 323.5 26.9 440.1 41.7 1.36 0.0296 10569545 Nadsyn1 90.4 7.4 123.0 12.6 1.36 0.0325 10488594 Rbck1 380.4 29.5 517.4 31.4 1.36 0.0156 10603860 Cfp 1093.7 52.9 1487.3 174.6 1.36 0.0293 10481900 Rabepk 130.5 2.2 177.5 10.5 1.36 0.0039 10529305 Tmem129 246.3 21.8 334.9 34.7 1.36 0.0363 10499529 Rag1ap1 490.1 32.1 666.3 1.1 1.36 0.0052 10464529 Tcirg1 986.8 87.0 1341.2 57.0 1.36 0.0157 10518837 Camta1 278.3 34.2 378.0 25.1 1.36 0.0403 10540215 Slc25a26 140.8 4.5 191.2 0.8 1.36 0.0006 10541895 Tnfrsf1a 952.4 57.0 1293.6 11.6 1.36 0.0042 10418027 Comtd1 122.8 14.2 166.8 7.7 1.36 0.0302 10575074 Tmco7 101.0 8.5 137.1 4.6 1.36 0.0129 10425852 Parvb 122.8 8.3 166.8 9.3 1.36 0.0113 10493449 Thbs3 90.7 5.2 123.1 5.8 1.36 0.0073 10468746 Hspa12a 213.3 21.4 289.5 3.6 1.36 0.0177 10507347 Tesk2 156.6 3.5 212.6 21.0 1.36 0.0160 10550650 Ercc1 224.1 16.6 304.2 3.6 1.36 0.0077 10569134 Deaf1 134.8 5.7 182.9 25.2 1.36 0.0409 10509930 Fbxo42 407.8 12.9 553.3 37.8 1.36 0.0071 10543697 Zc3hc1 147.6 8.9 200.2 18.4 1.36 0.0207 10403664 B3galnt2 212.3 6.9 287.9 1.1 1.36 0.0007 10578619 Cdkn2aip 148.5 8.6 201.5 20.2 1.36 0.0237 10471171 Fubp3 275.9 14.8 373.9 5.4 1.36 0.0033 10512022 Mobkl2b 326.8 40.5 442.9 15.2 1.36 0.0339 10433494 Nubp1 342.8 27.0 464.6 25.5 1.36 0.0151 10495830 Sec24d 183.2 17.0 248.2 9.8 1.35 0.0177 10386388 Snap47 166.2 15.0 225.2 25.9 1.35 0.0443 10570437 Fbxo25 237.2 30.1 321.3 14.3 1.35 0.0380 10437817 Pdxdc1 434.7 17.0 588.7 37.6 1.35 0.0073 10407792 Gpr137b-ps 1459.1 167.6 1975.7 183.1 1.35 0.0467 10411958 Rnf180 651.6 53.7 882.3 50.6 1.35 0.0173 10580771 Ciapin1 206.0 3.7 278.8 32.7 1.35 0.0251 10566488 Trim3 338.0 9.2 457.3 49.3 1.35 0.0213 10465246 Frmd8 274.7 21.8 371.5 15.3 1.35 0.0129 10465812 Ttc9c 332.3 19.1 449.3 11.6 1.35 0.0048 10482089 Ndufa8 515.5 26.3 696.7 76.9 1.35 0.0276 10511679 Decr1 168.5 17.3 227.6 18.8 1.35 0.0359 10582390 Aprt 584.7 70.7 790.0 30.2 1.35 0.0337 10456194 Napg 358.9 30.5 484.9 26.3 1.35 0.0178 10465943 Dagla 130.8 12.5 176.7 16.2 1.35 0.0361 10393620 Cbx4 192.1 18.2 259.5 9.2 1.35 0.0184 10389245 Tada2l 113.2 14.6 152.9 3.2 1.35 0.0368 10350015 Adipor1 1124.9 29.4 1518.3 7.1 1.35 0.0004 10403903 Trim27 321.9 18.8 434.3 47.9 1.35 0.0301 10424781 Grina 1441.4 53.7 1944.6 63.1 1.35 0.0023 10491363 Mfn1 320.1 26.3 431.8 22.1 1.35 0.0163 10536895 Atp6v1f 1314.2 119.2 1772.1 188.6 1.35 0.0414 10569168 Slc25a22 141.2 7.4 190.3 17.5 1.35 0.0197 10425834 Samm50 317.8 25.4 428.1 42.2 1.35 0.0325 10511226 Acap3 207.7 12.6 279.7 0.3 1.35 0.0046 10464603 Aip 402.2 47.7 541.6 0.2 1.35 0.0295 10382610 Tsen54 137.1 8.7 184.5 6.0 1.35 0.0072 10427148 Zfp740 143.9 7.3 193.6 7.7 1.35 0.0053 10582209 Mthfsd 121.7 7.5 163.8 0.8 1.35 0.0049 10347531 Ankzf1 120.8 9.5 162.6 12.6 1.35 0.0231 10526656 Lrch4 658.2 25.8 885.6 66.9 1.35 0.0109 10348889 D2hgdh 122.5 17.8 164.7 1.2 1.34 0.0499 10553163 Nomo1 416.1 35.3 559.5 58.6 1.34 0.0385 10505630 Snapc3 250.3 23.0 336.6 6.4 1.34 0.0160 10580061 Il27ra 112.1 10.3 150.7 2.7 1.34 0.0158 10529581 Mrfap1 1225.4 65.8 1647.7 10.7 1.34 0.0034 10376733 Map2k3 479.4 40.3 644.6 17.3 1.34 0.0134 10507484 Eri3 362.0 20.3 486.6 51.4 1.34 0.0277 10461305 B3gat3 260.0 27.0 349.4 21.3 1.34 0.0303 10439130 Umps 298.8 31.5 401.6 14.2 1.34 0.0252 10348618 Asb1 97.8 8.0 131.4 15.3 1.34 0.0440 10491182 Eif5a2 112.6 12.9 151.3 5.7 1.34 0.0308 10438340 Comt1 1483.5 86.1 1993.3 45.2 1.34 0.0050 10485042 Zfp408 107.0 11.3 143.8 11.9 1.34 0.0392 10394040 Csnk1d 400.0 7.5 537.4 24.4 1.34 0.0023 10576152 Trappc2l 361.5 29.9 485.4 29.3 1.34 0.0196 10488482 Acss1 544.7 21.0 731.2 8.3 1.34 0.0014 10464618 Rps6kb2 261.1 12.8 350.6 11.8 1.34 0.0043 10542636 Pyroxd1 135.0 5.7 181.1 23.0 1.34 0.0369 10557951 Armc5 138.8 16.5 186.2 0.9 1.34 0.0310 10520718 Snx17 580.4 43.5 778.5 49.0 1.34 0.0174 10390299 Pnpo 414.9 35.9 556.4 62.8 1.34 0.0449 10408346 Gm9983 210.0 15.3 281.6 28.5 1.34 0.0321 10585732 Ulk3 162.6 10.6 218.0 15.2 1.34 0.0159 10418796 Dph3 195.8 12.2 262.5 7.0 1.34 0.0066 10465185 Ehbp1l1 413.7 27.0 554.4 40.0 1.34 0.0169 10463645 Sufu 153.9 14.9 206.2 12.8 1.34 0.0275 10405464 Grk6 323.3 18.3 433.2 6.2 1.34 0.0043 10465336 Mrpl49 220.3 9.4 295.2 3.1 1.34 0.0019 10452874 Atp6v1f 1073.3 122.6 1437.9 49.8 1.34 0.0313 10476136 Vps16 333.8 17.5 447.1 9.0 1.34 0.0039 10439642 Slc35a5 384.1 41.1 514.4 2.5 1.34 0.0238 10433228 Cluap1 103.3 8.1 138.2 5.6 1.34 0.0137 10588638 Tmem115 245.6 15.6 328.7 5.6 1.34 0.0061 10590983 Panx1 128.5 6.7 172.0 2.8 1.34 0.0036 10579347 Ifi30 4392.9 250.6 5876.0 300.9 1.34 0.0090 10452815 Xdh 145.9 5.5 195.1 7.7 1.34 0.0034 10449295 Cuta 976.0 71.2 1304.7 14.6 1.34 0.0087 10550906 Plaur 1949.0 138.1 2605.2 177.8 1.34 0.0181 10457862 Rprd1a 216.2 13.6 289.0 19.5 1.34 0.0150 10426909 Letmd1 341.3 10.6 456.1 42.2 1.34 0.0166 10360321 Dusp23 106.3 10.7 142.1 2.3 1.34 0.0213 10431528 Lmf2 427.7 54.7 571.5 4.1 1.34 0.0388 10479087 Stx16 204.3 19.2 273.0 17.5 1.34 0.0275 10584334 Siae 460.0 24.0 614.6 74.1 1.34 0.0368 10606658 Trmt2b 167.5 8.4 223.8 22.2 1.34 0.0239 10546184 Plxna1 520.8 20.2 695.5 94.6 1.34 0.0439 10449071 Rhot2 112.6 1.4 150.3 4.8 1.33 0.0008 10501879 Usp53 116.2 9.6 155.0 16.4 1.33 0.0408 10557560 Cdipt 570.3 69.8 760.3 35.3 1.33 0.0412 10401382 Numb 392.9 30.5 523.8 49.9 1.33 0.0328 10559420 Tmc4 92.5 3.9 123.3 8.7 1.33 0.0108 10385872 Slc22a5 119.1 5.0 158.7 16.9 1.33 0.0263 10582599 Nup133 242.5 28.5 323.1 18.7 1.33 0.0411 10370690 ORF61 474.2 31.8 631.8 41.3 1.33 0.0163 10372618 Frs2 141.7 5.3 188.8 2.5 1.33 0.0015 10524588 Ankrd13a 664.4 41.0 884.9 82.2 1.33 0.0253 10487858 Spef1 166.1 9.2 221.2 0.6 1.33 0.0040 10563303 Bax 178.9 18.1 238.2 16.7 1.33 0.0347 10560174 Sepw1 570.7 42.1 759.9 75.0 1.33 0.0331 10576524 Gm505 153.6 12.4 204.5 11.9 1.33 0.0200 10415262 Dcaf11 193.6 9.5 257.6 9.4 1.33 0.0051 10519151 Mib2 176.5 5.2 234.8 17.6 1.33 0.0102 10376603 Drg2 215.1 12.7 286.2 8.2 1.33 0.0064 10393509 Usp36 168.7 10.3 224.4 4.4 1.33 0.0061 10444936 Dhx16 283.5 16.2 377.1 12.4 1.33 0.0064 10544273 Clec5a 591.8 76.1 787.1 13.2 1.33 0.0419 10572432 Isyna1 382.7 33.2 508.9 3.5 1.33 0.0147 10591653 Tmem205 155.0 7.4 206.1 15.1 1.33 0.0133 10485183 Slc35c1 261.3 26.1 347.4 2.1 1.33 0.0214 10442922 Cox7c 591.6 8.8 785.9 21.6 1.33 0.0007 10535025 Got2 532.1 41.7 706.7 14.2 1.33 0.0120 10493519 Shc1 673.2 30.3 893.9 35.1 1.33 0.0048 10429885 Sharpin 460.8 8.8 611.9 12.9 1.33 0.0005 10364990 Eef2 3630.5 160.6 4820.3 30.2 1.33 0.0022 10430247 Txn2 698.4 31.7 927.2 42.0 1.33 0.0058 10566668 Socs6 169.0 10.2 224.3 2.1 1.33 0.0055 10488415 Cst3 4117.2 319.4 5462.0 80.2 1.33 0.0115 10599576 Ppdpf 410.4 29.6 544.4 61.5 1.33 0.0420 10348558 Scly 145.7 1.8 193.2 16.1 1.33 0.0116 10478409 Pkig 110.0 3.9 145.9 15.7 1.33 0.0261 10456206 Wdr7 401.6 32.4 532.7 44.8 1.33 0.0303 10605324 Slc10a3 318.6 24.3 422.5 39.2 1.33 0.0323 10508737 Eya3 336.5 37.1 446.3 23.5 1.33 0.0362 10449152 Rab40c 171.0 7.6 226.8 17.9 1.33 0.0149 10398874 Siva1 99.5 6.8 131.9 7.4 1.33 0.0147 10525406 Anapc7 180.0 23.6 238.7 2.5 1.33 0.0448 10529156 Ift172 95.9 8.4 127.1 0.5 1.33 0.0157 10582162 Cotl1 1274.3 142.5 1689.0 142.0 1.33 0.0496 10528880 Lmbr1 137.5 15.8 182.2 3.2 1.32 0.0331 10572637 Fam125a 318.4 31.5 421.8 19.5 1.32 0.0275 10386955 Cox10 153.4 7.7 203.3 1.6 1.32 0.0033 10487894 Rassf2 151.5 8.9 200.7 22.5 1.32 0.0364 10481320 Gtf3c4 195.7 14.8 259.3 12.7 1.32 0.0160 10494428 Txnip 3866.1 287.0 5120.9 138.3 1.32 0.0115 10506188 Pgm2 223.8 10.3 296.4 31.5 1.32 0.0286 10604906 Ids 722.8 60.8 957.3 42.8 1.32 0.0190 10366796 Mettl1 139.4 4.5 184.6 17.3 1.32 0.0188 10577560 Ikbkb 651.4 18.2 862.5 61.2 1.32 0.0091 10554704 Mesdc2 383.1 11.9 507.2 58.4 1.32 0.0304 10460767 Batf2 94.6 4.6 125.2 4.7 1.32 0.0054 10467697 Mms19 236.7 9.6 313.4 20.8 1.32 0.0100 10525387 Gpn3 145.1 9.0 192.0 14.5 1.32 0.0192 10535653 Zkscan14 152.7 8.9 202.1 3.5 1.32 0.0056 10507394 Hectd3 301.9 26.9 399.4 12.2 1.32 0.0190 10401737 Tmed8 143.0 15.3 189.1 9.9 1.32 0.0347 10552812 Irf3 271.2 9.8 358.6 16.8 1.32 0.0047 10430265 Eif3d 534.1 61.9 706.1 30.9 1.32 0.0391 10520734 Nrbp1 589.7 49.2 779.4 5.6 1.32 0.0141 10512431 Pigo 142.3 7.2 188.0 6.8 1.32 0.0058 10584095 Nfrkb 178.7 9.9 236.1 1.0 1.32 0.0045 10461176 Stx5a 444.5 26.9 587.2 8.0 1.32 0.0061 10421197 Chmp7 186.6 11.1 246.4 4.5 1.32 0.0061 10475525 Pldn 157.8 4.2 208.5 3.2 1.32 0.0007 10485241 Accs 125.2 8.0 165.3 7.9 1.32 0.0119 10415030 Oxa1l 423.3 40.7 558.8 7.9 1.32 0.0214 10420035 Ipo4 295.6 24.5 390.0 28.9 1.32 0.0285 10451955 Sema6b 139.1 7.2 183.6 8.9 1.32 0.0084 10448506 Ccnf 118.9 7.5 156.9 6.4 1.32 0.0103 10530652 Scfd2 160.5 11.6 211.8 9.9 1.32 0.0146 10425018 Rpl8 2386.6 101.5 3148.4 84.1 1.32 0.0032 10573401 Trmt1 261.1 7.9 344.4 33.4 1.32 0.0206 10376690 Llgl1 131.6 14.1 173.6 5.0 1.32 0.0303 10405994 Med10 527.1 58.3 695.0 20.1 1.32 0.0331 10603051 Ap1s2 406.5 43.3 535.9 39.4 1.32 0.0434 10526153 Tyw1 205.2 16.3 270.4 18.4 1.32 0.0248 10539710 Tia1 172.6 15.2 227.4 9.8 1.32 0.0217 10476728 Dtd1 114.8 5.9 151.2 0.6 1.32 0.0037 10383395 Slc25a10 169.1 8.6 222.7 17.7 1.32 0.0180 10588547 Vprbp 236.9 19.9 311.9 16.8 1.32 0.0225 10592790 Hinfp 130.4 9.9 171.7 14.3 1.32 0.0294 10585099 Usp28 142.5 6.1 187.5 13.5 1.32 0.0129 10591668 Rgl3 141.4 6.4 186.1 11.3 1.32 0.0100 10516678 Kpna6 421.3 40.0 554.1 2.6 1.32 0.0211 10497421 Hps3 454.3 33.1 597.4 22.8 1.31 0.0138 10383502 Slc16a3 441.5 31.4 580.1 14.2 1.31 0.0110 10442495 Pkd1 227.8 14.7 299.3 7.9 1.31 0.0089 10572962 Prmt10 204.8 21.3 269.1 5.9 1.31 0.0285 10545692 Tet3 221.8 20.8 291.4 22.5 1.31 0.0376 10491945 Rab33b 185.5 8.2 243.7 27.6 1.31 0.0346 10493435 Gba 1434.3 38.4 1884.1 61.3 1.31 0.0019 10470584 Tsc1 166.2 1.2 218.2 26.4 1.31 0.0336 10498095 Cog6 252.6 10.3 331.6 5.4 1.31 0.0023 10566438 Fam160a2 188.8 21.7 247.8 9.8 1.31 0.0402 10530641 Usp46 100.0 6.3 131.3 0.6 1.31 0.0070 10516348 Eif2c3 211.9 13.5 278.1 8.7 1.31 0.0094 10430372 Rac2 1371.6 74.2 1798.9 184.3 1.31 0.0315 10452030 Plin3 663.1 24.3 869.3 70.0 1.31 0.0152 10504849 Stx17 272.0 23.7 356.5 8.2 1.31 0.0188 10352562 Gpatch2 160.5 5.5 210.3 0.2 1.31 0.0012 10526897 Unc84a 213.3 15.8 279.4 16.0 1.31 0.0197 10601088 Gm9078 179.5 12.4 235.1 27.4 1.31 0.0476 10475981 Chchd5 100.0 2.4 130.9 15.9 1.31 0.0366 10520234 Chpf2 166.3 16.5 217.8 8.9 1.31 0.0295 10443730 Abcg1 6580.7 391.1 8617.3 152.2 1.31 0.0067 10391431 Aarsd1 182.0 10.7 238.4 11.7 1.31 0.0112 10509790 Aldh4a1 99.9 10.0 130.8 1.6 1.31 0.0257 10463462 Sfxn3 1007.8 100.8 1319.6 107.8 1.31 0.0454 10524248 Ddx51 171.7 19.4 224.8 2.9 1.31 0.0353 10557405 Rabep2 124.5 5.9 162.9 6.6 1.31 0.0063 10538100 Repin1 108.4 9.3 141.9 6.0 1.31 0.0220 10589350 Shisa5 1274.2 47.1 1667.9 156.2 1.31 0.0218 10429972 Cpsf1 235.5 11.1 308.3 15.4 1.31 0.0081 10490736 Rgs19 630.2 66.5 824.6 48.4 1.31 0.0398 10364293 Ube2g2 320.5 23.4 419.2 17.6 1.31 0.0154 10351163 Scyl3 271.7 7.2 355.3 5.9 1.31 0.0009 10560826 Zfp109 131.0 13.9 171.3 7.2 1.31 0.0354 10605507 Gm5939 303.5 17.8 396.8 49.6 1.31 0.0499 10443869 Cyp4f16 683.4 67.9 893.4 17.4 1.31 0.0265 10373009 Tsfm 200.7 11.1 262.4 15.6 1.31 0.0133 10510957 Pank4 203.1 23.9 265.5 6.4 1.31 0.0412 10463224 Marveld1 849.8 90.6 1110.5 84.3 1.31 0.0484 10380823 Lasp1 986.8 54.9 1289.1 19.2 1.31 0.0056 10527133 Wipi2 204.4 2.5 267.0 0.2 1.31 0.0001 10516325 Adprhl2 207.2 19.5 270.6 5.0 1.31 0.0231 10395058 Adi1 187.1 12.8 244.4 12.4 1.31 0.0159 10452118 Lonp1 231.2 7.4 301.9 13.9 1.31 0.0046 10352320 Tmem63a 539.7 55.5 704.8 12.5 1.31 0.0292 10540860 Atg7 922.2 90.8 1203.9 45.5 1.31 0.0295 10590968 Ankrd49 154.7 5.4 201.9 8.0 1.31 0.0040 10545339 Mrpl35 186.5 10.0 243.4 6.2 1.30 0.0060 10451421 Klhdc3 519.2 21.8 677.2 24.9 1.30 0.0048 10597162 Klhl18 159.2 3.5 207.7 20.2 1.30 0.0213 10592830 Vps11 456.1 18.0 594.6 1.6 1.30 0.0019 10479833 Optn 108.1 5.6 140.9 10.7 1.30 0.0184 10364455 Cdc34 243.8 18.8 317.6 31.2 1.30 0.0418 10559504 Leng9 134.2 6.6 174.9 10.7 1.30 0.0123 10381187 Atp6v0a1 1065.2 62.6 1387.6 163.5 1.30 0.0461 10411306 Polk 162.1 9.1 211.2 10.7 1.30 0.0115 10402766 Akt1 1205.6 92.3 1570.3 53.0 1.30 0.0162 10501282 Cyb561d1 249.3 7.4 324.6 31.0 1.30 0.0222 10354054 Mitd1 187.7 13.0 244.4 15.0 1.30 0.0201 10501661 Sfrs3 2165.0 16.9 2819.1 132.3 1.30 0.0027 10456891 Atp5a1 2867.3 152.0 3733.4 287.0 1.30 0.0195 10525464 Orai1 253.5 18.1 329.9 31.5 1.30 0.0376 10355611 Zfp142 179.9 15.3 234.1 7.3 1.30 0.0204 10432411 Mcrs1 203.4 17.8 264.6 3.9 1.30 0.0198 10569786 Pnpla6 260.0 4.7 338.1 13.0 1.30 0.0020 10359506 Mettl13 105.2 8.4 136.8 5.7 1.30 0.0199 10368935 Qrsl1 123.4 7.6 160.5 5.1 1.30 0.0098 10438112 Pi4ka 461.9 4.6 600.5 31.6 1.30 0.0039 10475293 Tubgcp4 178.8 3.3 232.3 13.9 1.30 0.0062 10581729 Ddx19a 216.2 17.8 280.8 6.1 1.30 0.0178 10430058 Cyhr1 208.1 12.6 270.3 1.3 1.30 0.0071 10571696 Casp3 128.4 15.0 166.7 3.6 1.30 0.0430 10541771 Ing4 354.2 17.5 460.0 56.0 1.30 0.0466 10421723 Dnajc15 161.8 15.6 210.1 9.5 1.30 0.0314 10525751 Ddx55 130.5 1.6 169.3 9.6 1.30 0.0050 10586347 Parp16 197.7 13.2 256.5 21.1 1.30 0.0287 10592763 Nlrx1 323.5 13.2 419.6 23.6 1.30 0.0090 10592856 Ccdc84 94.3 6.9 122.4 7.7 1.30 0.0235 10409396 Uimc1 258.8 23.8 335.8 13.9 1.30 0.0278 10367282 Cnpy2 236.6 18.6 306.9 22.8 1.30 0.0312 10425053 Ncf4 346.2 20.4 449.0 22.0 1.30 0.0126 10478590 Zswim1 93.7 8.7 121.4 10.2 1.30 0.0463 10375065 Sh3pxd2b 607.9 11.2 788.1 58.0 1.30 0.0108 10501593 Slc30a7 683.1 34.5 885.5 97.2 1.30 0.0386 10583573 Atg4d 131.0 2.2 169.7 7.9 1.30 0.0032 10555470 Arap1 253.7 13.4 328.7 15.2 1.30 0.0099 10586130 Aagab 184.8 4.5 239.5 3.1 1.30 0.0007 10460376 Ppp1ca 1850.8 171.2 2398.1 30.1 1.30 0.0238 10388884 Nlk 311.2 25.3 403.2 37.8 1.30 0.0439 10473240 Eno1 2234.9 161.8 2894.6 203.6 1.30 0.0265 10434675 Dnajb11 576.3 28.3 746.4 1.7 1.30 0.0040 10444927 Nrm 337.2 10.0 436.7 17.9 1.29 0.0037 10440800 Urb1 177.1 9.4 229.3 4.2 1.29 0.0058 10352725 Tmem206 184.8 6.5 239.2 21.2 1.29 0.0208 10434148 Trmt2a 262.3 18.5 339.6 16.8 1.29 0.0181 10446084 Kdm4b 176.2 5.1 228.0 1.6 1.29 0.0009 10504564 Dcaf10 163.3 7.6 211.3 15.6 1.29 0.0172 10534041 Stx2 130.3 1.9 168.5 2.2 1.29 0.0002 10364601 Abca7 255.6 11.5 330.7 36.0 1.29 0.0366 10559486 Lair1 499.1 41.0 645.6 57.6 1.29 0.0424 10378013 Rpain 161.6 6.0 209.0 9.7 1.29 0.0061 10475957 Ttl 148.5 14.8 192.0 4.9 1.29 0.0311 10606969 Rbm41 117.9 7.9 152.4 4.7 1.29 0.0123 10569953 Snapc2 109.1 10.8 141.1 8.3 1.29 0.0402 10474860 Chst14 124.0 3.6 160.2 1.9 1.29 0.0011 10497931 Cflar 356.5 16.0 460.8 15.3 1.29 0.0054 10460061 Zfp407 233.6 24.4 301.9 10.6 1.29 0.0370 10580231 Gm5911 141.6 10.0 182.9 10.2 1.29 0.0205 10516393 Eif2c4 131.9 8.6 170.4 8.3 1.29 0.0156 10564888 Unc45a 236.3 10.8 305.3 0.5 1.29 0.0033 10468059 Fbxw4 309.9 14.1 400.2 20.7 1.29 0.0094 10368762 Cdc40 349.9 5.8 451.9 5.7 1.29 0.0003 10370072 Prmt2 202.5 5.3 261.4 30.8 1.29 0.0387 10351347 Creg1 1056.4 98.3 1363.8 113.6 1.29 0.0475 10474526 Lpcat4 159.3 9.3 205.6 14.4 1.29 0.0204 10388352 Sgsm2 114.5 8.9 147.8 7.5 1.29 0.0231 10476401 Plcb1 230.7 19.5 297.7 14.7 1.29 0.0267 10395049 Rnaseh1 129.4 8.7 166.9 11.8 1.29 0.0251 10550674 Ercc2 151.1 6.3 194.9 14.5 1.29 0.0164 10361031 Rps6kc1 219.8 22.2 283.4 21.0 1.29 0.0495 10427255 Tarbp2 152.0 4.6 196.1 6.3 1.29 0.0027 10562416 Cebpg 458.7 42.6 591.6 7.4 1.29 0.0254 10496397 Mapksp1 1141.5 82.3 1472.0 111.2 1.29 0.0300 10426225 Ncaph2 354.5 28.8 457.1 44.5 1.29 0.0484 10522430 Dcun1d4 112.2 5.4 144.7 12.6 1.29 0.0249 10486172 Fam82a2 168.4 7.2 217.0 0.1 1.29 0.0028 10583326 Slc36a4 1025.4 51.1 1321.3 141.9 1.29 0.0388 10586110 Cln6 451.2 38.8 581.3 34.8 1.29 0.0320 10344952 Rdh10 139.4 4.4 179.6 10.1 1.29 0.0077 10534551 Lrwd1 138.5 4.6 178.4 11.9 1.29 0.0113 10552697 Napsa 323.9 24.7 417.1 27.6 1.29 0.0284 10518031 Dnajc16 318.6 12.4 410.3 24.4 1.29 0.0102 10460237 Unc93b1 1035.9 79.8 1333.9 15.3 1.29 0.0157 10374453 Glul 2732.8 110.4 3518.5 103.8 1.29 0.0041 10425477 Sgsm3 208.4 20.9 268.2 19.9 1.29 0.0498 10442986 Luc7l 287.7 22.7 370.1 9.4 1.29 0.0185 10426065 Tbc1d22a 531.8 36.2 684.1 7.9 1.29 0.0114 10429666 Pycrl 176.1 20.6 226.5 2.8 1.29 0.0468 10348087 Cops7b 191.4 14.4 246.2 18.1 1.29 0.0316 10586397 Mtfmt 172.5 13.3 221.9 0.9 1.29 0.0157 10577190 Rasa3 288.4 8.2 370.9 3.3 1.29 0.0010 10593130 Sidt2 1091.5 62.7 1403.5 3.2 1.29 0.0069 10400546 Fbxo33 216.2 16.9 278.0 7.6 1.29 0.0185 10522396 Ociad1 818.1 56.4 1051.8 64.3 1.29 0.0227 10571274 Gsr 1718.8 63.0 2209.6 57.8 1.29 0.0031 10515519 Atp6v0b 2260.6 96.3 2903.9 223.3 1.28 0.0186 10572180 Atp13a1 293.7 15.7 377.1 1.6 1.28 0.0057 10411156 Scamp1 260.5 26.2 334.4 20.4 1.28 0.0453 10402268 Lgmn 2093.7 89.1 2687.1 110.2 1.28 0.0067 10503363 Rbm12b 278.0 18.6 356.8 11.7 1.28 0.0138 10585988 Myo9a 437.5 16.1 560.9 25.4 1.28 0.0063 10355567 Tmbim1 2133.6 142.5 2735.2 8.8 1.28 0.0109 10393395 Sfrs2 1356.7 146.0 1739.0 68.8 1.28 0.0446 10512165 Nol6 327.9 33.8 420.1 17.1 1.28 0.0410 10522976 Rufy3 123.1 13.0 157.7 2.3 1.28 0.0386 10596207 Uba5 400.2 7.7 512.5 36.0 1.28 0.0109 10511069 Gnb1 3328.6 207.0 4262.2 183.3 1.28 0.0144 10419471 Tep1 478.9 16.0 612.9 4.5 1.28 0.0016 10433735 Abcc1 364.8 28.7 466.6 5.8 1.28 0.0181 10477970 Src 102.3 5.3 130.9 14.1 1.28 0.0426 10477286 Pofut1 167.3 2.7 214.0 4.9 1.28 0.0007 10441740 Agpat4 241.8 13.3 309.2 19.8 1.28 0.0183 10583788 Prkcsh 382.8 13.5 489.5 19.8 1.28 0.0052 10529133 Zfp513 224.8 14.8 287.2 20.7 1.28 0.0276 10574471 Cmtm3 1293.2 61.0 1652.1 135.3 1.28 0.0240 10368806 Smpd2 322.1 20.0 411.4 4.6 1.28 0.0097 10596637 Mapkapk3 678.3 37.8 866.2 46.0 1.28 0.0149 10504362 Rgp1 183.0 14.1 233.6 10.2 1.28 0.0233 10409170 Fgd3 142.6 10.7 182.1 9.4 1.28 0.0245 10402519 Atg2b 246.6 4.0 314.8 10.7 1.28 0.0017 10503259 Trp53inp1 358.4 17.2 457.5 40.5 1.28 0.0284 10474545 Slc12a6 675.8 76.1 862.6 27.3 1.28 0.0497 10424965 Ppp1r16a 115.6 6.7 147.5 7.7 1.28 0.0160 10560260 Sae1 476.2 40.5 607.5 23.8 1.28 0.0277 10568228 Zfp747 133.7 10.4 170.6 8.6 1.28 0.0262 10468584 Zdhhc6 268.4 6.5 342.3 29.4 1.28 0.0199 10431874 Slc38a1 732.7 26.4 934.5 40.4 1.28 0.0061 10416375 Med4 126.6 4.2 161.4 13.1 1.28 0.0194 10381588 Grn 4356.3 243.7 5553.9 200.8 1.27 0.0107 10514884 Mrpl37 266.8 26.9 340.0 6.6 1.27 0.0368 10357124 Tsn 548.5 40.2 699.0 33.8 1.27 0.0229 10579996 Tecr 1111.3 11.7 1416.3 72.5 1.27 0.0044 10479726 Pcmtd2 219.4 9.6 279.6 7.8 1.27 0.0053 10579744 Large 272.6 6.6 347.3 11.5 1.27 0.0024 10581289 Atp6v0d1 1578.8 96.7 2011.7 44.9 1.27 0.0107 10412345 Parp8 635.3 53.1 809.2 41.3 1.27 0.0309 10373202 Shmt2 201.3 16.0 256.5 1.6 1.27 0.0193 10559270 Tssc4 95.3 4.9 121.3 1.0 1.27 0.0059 10510464 Lzic 120.4 8.1 153.3 2.6 1.27 0.0131 10494060 Mrpl9 204.4 12.6 260.3 21.6 1.27 0.0323 10441313 C2cd2 149.5 11.5 190.2 7.4 1.27 0.0229 10422028 Tbc1d4 118.9 6.8 151.3 5.4 1.27 0.0114 10519105 Ski 1169.0 104.6 1486.8 107.9 1.27 0.0460 10531919 Hsd17b11 937.9 44.4 1192.9 76.6 1.27 0.0164 10451363 Srf 255.8 26.1 325.2 10.9 1.27 0.0418 10405545 Pcbd2 302.1 1.0 383.9 24.6 1.27 0.0081 10390653 Med24 280.3 26.5 356.1 8.2 1.27 0.0332 10533304 Trafd1 673.7 15.2 855.6 29.3 1.27 0.0025 10591544 Yipf2 137.7 6.5 174.8 7.4 1.27 0.0095 10559853 Clcn4-2 551.8 23.1 700.6 80.3 1.27 0.0472 10579335 Pgpep1 216.4 6.3 274.8 0.4 1.27 0.0011 10575685 Nudt7 95.1 3.4 120.7 4.0 1.27 0.0044 10392449 Wipi1 120.7 7.9 153.2 9.7 1.27 0.0251 10564857 Idh2 578.7 22.0 734.6 68.4 1.27 0.0292 10403273 Asb13 234.1 8.4 297.0 11.4 1.27 0.0054 10406795 Gfm2 189.2 2.3 240.1 12.3 1.27 0.0047 10371256 Sirt6 154.3 15.2 195.7 5.3 1.27 0.0380 10481734 Lrsam1 145.3 13.2 184.3 9.0 1.27 0.0374 10388392 Dph1 162.9 4.1 206.7 24.8 1.27 0.0470 10372082 Nudt4 246.3 15.5 312.4 28.3 1.27 0.0394 10526427 Dtx2 97.9 6.3 124.2 11.2 1.27 0.0400 10420516 Cdadc1 247.1 8.7 313.3 8.4 1.27 0.0035 10546056 Rab43 198.8 12.5 252.1 0.9 1.27 0.0106 10425341 Map3k7ip1 125.6 2.5 159.3 11.9 1.27 0.0140 10493210 Smg5 243.3 3.7 308.5 0.8 1.27 0.0002 10357917 Tmem183a 213.6 2.8 270.9 16.5 1.27 0.0077 10469070 Nudt5 239.3 16.1 303.4 14.1 1.27 0.0201 10460085 Cndp2 1576.2 98.7 1998.0 76.8 1.27 0.0152 10591446 Tyk2 388.4 2.8 492.3 13.3 1.27 0.0008 10589511 Scap 397.4 13.4 503.7 11.4 1.27 0.0028 10534142 Sbds 385.3 13.4 488.3 31.1 1.27 0.0127 10374185 Ccm2 422.6 32.3 535.6 23.4 1.27 0.0250 10562847 Nr1h2 556.2 21.6 704.9 71.4 1.27 0.0359 10543572 Impdh1 122.0 7.7 154.6 10.6 1.27 0.0265 10578157 Tnks 367.8 21.3 466.0 12.9 1.27 0.0108 10481457 Sh3glb2 241.4 11.4 305.8 5.0 1.27 0.0054 10580010 Pkn1 749.0 41.0 948.9 0.7 1.27 0.0072 10581395 Slc12a4 293.1 14.3 371.3 36.0 1.27 0.0369 10376721 Smcr8 334.0 0.9 423.1 29.0 1.27 0.0101 10352459 Rab3gap2 303.8 4.6 384.9 10.6 1.27 0.0011 10388227 Cyb5d2 158.1 15.3 200.3 4.4 1.27 0.0360 10347481 Cyp27a1 110.6 6.7 140.1 4.3 1.27 0.0125 10381072 Cdc6 129.8 13.1 164.4 5.1 1.27 0.0422 10568217 Dctpp1 197.6 10.8 250.1 15.1 1.27 0.0189 10575184 Wwp2 345.2 19.7 436.6 0.4 1.26 0.0084 10569542 Mrgpre 109.6 9.7 138.7 1.6 1.26 0.0284 10596481 Abhd14a 156.1 10.9 197.4 5.9 1.26 0.0177 10364971 Map2k2 436.9 23.1 552.5 26.0 1.26 0.0135 10510034 Casp9 444.3 28.5 561.9 21.7 1.26 0.0165 10351749 Dcaf8 409.7 17.6 518.1 22.8 1.26 0.0089 10485225 Ext2 497.4 34.6 628.8 10.9 1.26 0.0157 10393851 Pcyt2 166.9 14.4 211.0 9.4 1.26 0.0338 10347796 Rhbdd1 373.0 31.1 471.4 26.6 1.26 0.0359 10607587 Pdha1 666.3 37.6 841.9 21.8 1.26 0.0102 10399897 Hbp1 876.1 46.1 1106.6 4.9 1.26 0.0068 10449644 Glo1 230.0 21.6 290.5 2.8 1.26 0.0334 10437561 Fam86 173.3 17.1 218.8 8.5 1.26 0.0434 10364683 Stk11 525.5 17.9 663.7 41.3 1.26 0.0123 10345357 Imp4 448.7 19.2 566.6 11.8 1.26 0.0048 10512791 Tbc1d2 240.8 16.8 304.1 21.3 1.26 0.0330 10503109 Chchd7 297.8 18.7 376.0 28.5 1.26 0.0317 10576191 Spg7 188.4 6.9 237.9 2.4 1.26 0.0026 10516081 Ppie 107.1 11.0 135.2 0.4 1.26 0.0411 10574903 Edc4 212.8 12.3 268.6 6.2 1.26 0.0105 10594501 Ptplad1 340.8 4.4 430.1 19.9 1.26 0.0039 10538206 Ccdc126 110.4 4.4 139.3 10.7 1.26 0.0215 10445033 Trim26 178.8 14.6 225.6 10.8 1.26 0.0315 10574789 Fam65a 213.8 12.6 269.8 3.0 1.26 0.0098 10385486 Trim41 288.2 22.6 363.5 4.6 1.26 0.0214 10465485 Esrra 217.9 16.5 274.9 17.2 1.26 0.0335 10517083 Pigv 171.4 2.3 216.2 10.9 1.26 0.0049 10596442 Ppm1m 313.3 15.3 395.1 14.6 1.26 0.0095 10492997 Etv3 214.2 2.0 270.1 13.9 1.26 0.0049 10451238 Polr1c 291.3 29.7 367.3 11.4 1.26 0.0454 10380403 Lrrc59 772.8 26.8 974.4 6.8 1.26 0.0022 10370721 Sbno2 455.1 36.2 573.9 25.7 1.26 0.0294 10452000 Dpp9 352.4 23.3 444.2 16.4 1.26 0.0178 10480541 Ehmt1 196.5 15.8 247.7 8.6 1.26 0.0270 10425293 Cby1 139.2 5.4 175.4 9.1 1.26 0.0103 10444420 Agpat1 453.4 34.6 571.3 18.9 1.26 0.0237 10406203 Stoml2 350.3 20.9 441.2 29.2 1.26 0.0254 10439239 Dirc2 1240.8 20.9 1563.0 34.3 1.26 0.0009 10535938 N4bp2l1 164.8 4.4 207.6 5.2 1.26 0.0022 10525210 AU042671 230.8 6.1 290.5 6.1 1.26 0.0017 10388451 Wdr81 312.4 30.0 393.3 16.4 1.26 0.0434 10547926 Cops7a 642.7 21.7 808.9 65.9 1.26 0.0226 10567608 Cog7 271.7 16.9 342.0 32.4 1.26 0.0454 10386473 Srebf1 403.2 18.6 507.3 26.4 1.26 0.0131 10408348 Mrs2 229.9 3.2 289.3 8.8 1.26 0.0014 10507250 Pomgnt1 230.6 16.9 290.1 23.6 1.26 0.0438 10596271 Dnajc13 1151.3 80.3 1448.2 83.2 1.26 0.0280 10424825 Cyc1 619.6 36.0 779.2 73.0 1.26 0.0424 10525296 Brap 408.7 22.1 513.9 12.3 1.26 0.0096 10380732 Mrpl10 324.7 21.2 408.2 18.4 1.26 0.0205 10386495 Tom1l2 179.7 10.4 225.9 0.5 1.26 0.0096 10583472 Pin1 174.7 6.8 219.6 15.6 1.26 0.0187 10450682 H2-T23 435.3 19.9 547.0 26.7 1.26 0.0120 10564377 Lrrk1 301.4 19.9 378.8 21.5 1.26 0.0256 10535725 Rnf6 361.7 16.4 454.5 23.5 1.26 0.0129 10569319 Ctsd 11652.5 877.6 14638.3 573.5 1.26 0.0255 10449363 Nudt3 353.4 26.3 443.9 11.4 1.26 0.0216 10360130 Nit1 354.1 25.7 444.8 24.5 1.26 0.0294 10596925 Ndufaf3 170.7 10.1 214.4 13.9 1.26 0.0251 10495574 Sass6 125.1 4.7 157.0 12.4 1.26 0.0232 10535065 Adap1 308.1 23.6 386.9 7.7 1.26 0.0223 10546104 Eefsec 223.7 13.1 280.9 17.5 1.26 0.0236 10568638 Uros 107.8 10.6 135.3 4.7 1.26 0.0452 10542040 Parp11 107.9 3.0 135.5 4.3 1.26 0.0033 10572516 Mtap1s 232.2 17.0 291.4 25.1 1.26 0.0481 10444978 Gnal1 250.2 11.3 313.9 16.6 1.25 0.0135 10411680 Marveld2 288.2 19.9 361.4 16.6 1.25 0.0239 10572408 Fkbp8 787.1 29.4 986.5 78.5 1.25 0.0237 10546092 Rab7 840.6 25.7 1053.5 79.0 1.25 0.0189 10497300 Zfand1 187.8 16.7 235.3 15.5 1.25 0.0495 10460696 Slc25a45 406.5 22.1 509.3 35.8 1.25 0.0261 10567022 Btbd10 136.9 11.0 171.5 3.9 1.25 0.0260 10560818 Zfp111 105.8 6.5 132.6 7.5 1.25 0.0232 10426550 Tmem106c 173.4 10.1 217.3 17.3 1.25 0.0341 10426110 Pim3 204.5 6.0 256.2 25.6 1.25 0.0358 10496748 Syde2 183.0 13.7 229.1 4.4 1.25 0.0219 10367305 Ankrd52 291.9 10.3 365.4 21.4 1.25 0.0125 10415176 Dhrs4 172.1 10.1 215.4 15.2 1.25 0.0293 10466735 Fam189a2 530.2 15.3 663.6 57.6 1.25 0.0261 10351277 Nme7 97.2 5.9 121.7 1.6 1.25 0.0123 10488982 Cpne1 584.8 16.9 731.7 46.6 1.25 0.0129 10532919 Rps23 2839.2 144.5 3552.1 26.5 1.25 0.0072 10373924 Ascc2 286.3 3.0 358.0 11.4 1.25 0.0015 10442893 Wdr24 100.2 2.4 125.2 10.7 1.25 0.0241 10559635 Hspbp1 202.6 9.5 252.9 21.1 1.25 0.0317 10411373 Hexb 824.3 43.7 1028.8 28.0 1.25 0.0106 10437311 Trap1 531.9 33.3 663.7 60.2 1.25 0.0468 10410039 Ptch1 96.9 1.6 120.9 9.2 1.25 0.0171 10511207 Cpsf3l 200.8 5.9 250.4 10.7 1.25 0.0062 10581577 Dhx38 247.6 4.5 308.7 14.2 1.25 0.0050 10356278 Sp110 300.0 18.9 374.1 31.9 1.25 0.0432 10387363 Cyb5d1 172.3 11.5 214.9 0.0 1.25 0.0156 10578810 Clcn3 174.7 7.7 217.8 12.3 1.25 0.0157 10349793 Dstyk 219.5 11.8 273.6 3.3 1.25 0.0091 10426098 Creld2 365.9 28.4 456.1 8.2 1.25 0.0251 10508892 Gpatch3 123.4 9.0 153.8 7.7 1.25 0.0301 10566405 Mapksp1 1112.2 88.3 1385.7 81.9 1.25 0.0402 10559406 Tfpt 309.4 20.9 385.4 5.5 1.25 0.0172 10546294 Nup210 719.2 63.7 895.6 1.5 1.25 0.0340 10571128 Prosc 416.0 23.3 517.9 50.5 1.24 0.0491 10388033 Derl2 458.5 30.5 570.5 33.0 1.24 0.0297 10544148 Jhdm1d 621.4 35.3 772.9 15.7 1.24 0.0119 10552760 Pnkp 235.4 18.0 292.7 2.3 1.24 0.0236 10451123 Slc29a1 1600.5 72.8 1989.8 59.1 1.24 0.0084 10528484 Srpk2 395.9 30.9 492.1 18.9 1.24 0.0312 10526520 Plod3 1059.5 81.8 1317.0 97.9 1.24 0.0484 10351390 Tada1l 280.1 16.0 348.1 3.4 1.24 0.0111 10444008 Zfp414 230.3 8.4 286.2 10.2 1.24 0.0066 10374119 Ogdh 1501.1 112.7 1865.2 146.7 1.24 0.0497 10577604 Agpat6 277.2 17.1 344.3 3.5 1.24 0.0136 10442739 Unkl 165.4 6.6 205.4 19.4 1.24 0.0387 10347639 Gmppa 396.7 17.8 492.7 11.8 1.24 0.0073 10529549 Tbc1d14 452.1 13.9 561.5 11.0 1.24 0.0027 10588642 Tusc4 162.7 12.1 202.0 13.7 1.24 0.0422 10541729 Cdca3 171.3 2.8 212.7 12.2 1.24 0.0087 10488926 Mmp24 164.7 6.9 204.5 1.9 1.24 0.0047 10449327 Lemd2 286.9 10.7 356.0 35.9 1.24 0.0436 10527430 Arpc1a 376.8 29.8 467.4 13.5 1.24 0.0303 10600453 Ikbkg 203.4 12.4 252.2 18.2 1.24 0.0349 10437483 Rogdi 144.1 7.0 178.7 1.4 1.24 0.0073 10593159 Pafah1b2 717.4 28.3 889.4 72.2 1.24 0.0289 10383453 Lrrc45 140.2 6.3 173.8 2.7 1.24 0.0064 10535586 Smurf1 200.1 6.4 248.0 26.8 1.24 0.0489 10563295 Ftl1 9916.5 388.7 12291.3 697.2 1.24 0.0148 10357158 Ralb 596.3 23.4 739.1 54.5 1.24 0.0239 10562927 Ptov1 205.8 10.5 255.1 2.8 1.24 0.0086 10523518 Enoph1 260.0 8.9 322.1 32.5 1.24 0.0429 10396094 Klhdc2 272.3 7.4 337.2 1.2 1.24 0.0013 10376269 Galnt10 201.6 15.7 249.7 0.2 1.24 0.0262 10463515 Hps6 107.6 6.4 133.2 6.7 1.24 0.0229 10418131 Polr3a 211.7 8.2 262.0 13.4 1.24 0.0126 10406111 Slc12a7 580.4 8.4 718.4 66.7 1.24 0.0307 10389300 Dhrs11 154.9 9.3 191.6 10.1 1.24 0.0244 10530536 Tec 319.7 9.6 395.6 41.1 1.24 0.0449 10409376 Hk3 179.3 15.0 221.8 9.0 1.24 0.0394 10598359 Syp 148.6 12.1 183.8 7.0 1.24 0.0363 10435565 Hcls1 1521.3 62.0 1881.4 115.5 1.24 0.0181 10433660 Bfar 240.2 6.5 297.0 12.9 1.24 0.0065 10551554 Sars2 119.8 3.8 148.1 12.9 1.24 0.0312 10360695 Nvl 288.7 26.1 356.3 13.6 1.23 0.0468 10487797 Adam33 127.0 3.9 156.7 0.4 1.23 0.0021 10534585 Sh2b2 337.9 19.5 416.6 2.4 1.23 0.0125 10425357 Smcr7l 143.4 8.0 176.8 4.7 1.23 0.0139 10557705 Phkg2 321.7 22.8 396.5 16.0 1.23 0.0292 10385926 Cdc42se2 763.5 39.9 940.6 58.7 1.23 0.0258 10473754 Kbtbd4 179.2 8.8 220.8 1.2 1.23 0.0080 10541910 Vwf 342.1 24.8 421.3 13.8 1.23 0.0281 10448755 Eme2 145.6 7.7 179.3 6.6 1.23 0.0151 10526302 Tbl2 147.8 7.1 182.0 8.0 1.23 0.0149 10493086 Hdgf 566.8 49.2 697.7 13.4 1.23 0.0393 10502196 Rpl34 367.7 24.7 452.6 19.7 1.23 0.0277 10386095 Fam114a2 250.9 7.3 308.9 14.3 1.23 0.0084 10377286 Pik3r6 615.5 53.7 756.9 4.1 1.23 0.0387 10395064 Tssc1 204.7 16.1 251.7 6.5 1.23 0.0329 10506569 Usp24 103.2 2.8 126.9 13.0 1.23 0.0452 10421394 Fam160b2 151.4 4.8 186.1 13.8 1.23 0.0233 10524882 Wsb2 595.6 10.3 732.2 37.3 1.23 0.0075 10542108 Tom1 442.1 14.0 543.5 0.4 1.23 0.0023 10368534 Ncoa7 129.3 2.8 159.0 2.9 1.23 0.0014 10478355 Mybl2 130.5 9.6 160.4 4.9 1.23 0.0293 10580139 Zswim4 207.2 9.0 254.7 16.6 1.23 0.0230 10549635 Gm4878 1143.8 50.7 1405.5 8.9 1.23 0.0063 10429114 Tmem71 149.1 12.2 183.2 3.6 1.23 0.0349 10459193 Ppargc1b 203.9 10.0 250.5 15.2 1.23 0.0238 10587780 Tuba1b 4523.9 111.0 5555.9 57.1 1.23 0.0013 10425302 Gtpbp1 430.6 29.0 528.8 23.9 1.23 0.0294 10346843 Nrp2 494.1 23.2 606.7 13.4 1.23 0.0091 10373101 Pip4k2c 366.1 33.4 449.5 10.0 1.23 0.0465 10564539 Mctp2 188.9 2.8 231.8 23.9 1.23 0.0436 10596815 Rnf123 251.3 5.6 308.3 4.9 1.23 0.0014 10458983 March3 109.1 7.6 133.8 7.6 1.23 0.0381 10509500 Hp1bp3 636.5 16.3 780.7 72.2 1.23 0.0365 10351689 Gm10521 110.5 7.1 135.4 3.6 1.23 0.0210 10483737 Atf2 458.1 17.6 561.5 8.5 1.23 0.0050 10532463 Pus1 217.9 18.9 267.1 2.5 1.23 0.0403 10386159 Zfp672 114.4 6.3 140.2 3.8 1.23 0.0150 10547140 Tmcc1 339.3 28.3 415.7 0.6 1.23 0.0360 10485395 Trim44 370.2 14.8 453.7 23.8 1.23 0.0155 10397518 Ahsa1 572.0 33.2 700.8 31.3 1.23 0.0227 10585825 Stoml1 134.7 8.3 165.0 4.0 1.23 0.0186 10494509 Pias3 121.4 3.3 148.7 7.8 1.22 0.0108 10570119 Carkd 276.4 22.4 338.5 6.9 1.22 0.0357 10538394 Plekha8 101.3 1.3 124.0 7.6 1.22 0.0119 10439701 Abhd10 132.6 3.7 162.4 13.6 1.22 0.0303 10596492 Parp3 364.6 8.9 446.2 1.7 1.22 0.0012 10445826 Mocs1 338.3 24.1 414.0 4.2 1.22 0.0249 10419977 Ap1g2 375.4 15.0 459.2 34.1 1.22 0.0287 10539119 Ggcx 184.8 6.1 226.1 8.9 1.22 0.0080 10417950 Ndst2 271.3 11.1 331.8 0.8 1.22 0.0053 10494299 Ensa 232.9 16.4 284.8 11.5 1.22 0.0320 10451434 Ppp2r5d 309.7 17.6 378.6 27.2 1.22 0.0381 10557831 Myst1 223.5 4.5 273.2 2.1 1.22 0.0008 10568188 Tbc1d10b 430.0 29.3 525.6 15.7 1.22 0.0263 10383282 Chmp6 226.0 13.7 276.2 2.1 1.22 0.0163 10378024 Mis12 201.3 7.1 246.0 8.8 1.22 0.0080 10581222 Fhod1 210.5 7.7 257.1 24.5 1.22 0.0456 10581507 Cog8 315.6 1.1 385.5 37.2 1.22 0.0377 10537934 Zfp212 169.5 14.1 207.1 2.0 1.22 0.0378 10362922 Atg5 463.3 26.0 565.8 26.6 1.22 0.0233 10455852 Prrc1 247.2 19.8 301.9 14.4 1.22 0.0458 10450226 Ppt2 872.5 56.6 1065.5 76.1 1.22 0.0452 10597182 Nbeal2 117.1 8.2 142.9 5.3 1.22 0.0307 10419542 Tmem55b 416.2 23.9 508.1 10.1 1.22 0.0160 10444496 Dom3z 184.6 13.3 225.3 1.7 1.22 0.0266 10420823 Hmbox1 235.7 5.6 287.7 17.5 1.22 0.0142 10446581 Zfp161 227.2 9.6 277.3 4.9 1.22 0.0071 10419073 Tspan14 1298.9 67.2 1585.2 31.4 1.22 0.0123 10380739 Osbpl7 166.9 5.7 203.6 0.7 1.22 0.0033 10426093 Zbed4 136.8 6.0 167.0 5.8 1.22 0.0115 10470665 Setx 199.5 4.5 243.5 3.8 1.22 0.0015 10492846 Pet112l 152.9 11.0 186.5 3.3 1.22 0.0274 10444756 Atp6v1g2 194.0 4.1 236.6 5.4 1.22 0.0020 10494664 Wars2 117.7 1.7 143.6 1.3 1.22 0.0004 10437698 Txndc11 268.1 16.4 327.0 13.2 1.22 0.0249 10585129 Zw10 158.0 1.1 192.6 12.5 1.22 0.0136 10431266 Cerk 453.2 23.6 552.6 21.9 1.22 0.0181 10481210 Vav2 562.0 38.0 685.0 8.5 1.22 0.0232 10532187 Gak 1333.4 117.4 1625.1 42.2 1.22 0.0482 10489004 Nfs1 352.7 29.1 429.8 4.9 1.22 0.0387 10433910 Top3b 272.7 10.8 332.0 6.6 1.22 0.0066 10552945 Gys1 223.7 7.9 272.4 9.1 1.22 0.0077 10582201 Cox4nb 276.2 15.5 336.2 12.8 1.22 0.0207 10520650 Cad 241.0 13.6 293.2 12.2 1.22 0.0224 10409220 Hist2h2aa1 2566.0 43.6 3122.1 237.5 1.22 0.0231 10589099 Ip6k2 131.0 8.0 159.4 6.4 1.22 0.0257 10576728 Xab2 367.0 26.0 446.3 3.8 1.22 0.0268 10526311 Bcl7b 306.2 7.7 372.2 19.1 1.22 0.0107 10363231 Smpdl3a 1371.6 98.8 1666.8 3.7 1.22 0.0279 10579219 Ddx49 204.5 14.9 248.5 8.9 1.21 0.0359 10353028 Vcpip1 375.0 9.8 455.4 11.0 1.21 0.0033 10426650 Tuba1c 3627.1 116.1 4403.8 22.0 1.21 0.0030 10500333 Hist2h4 776.2 6.7 942.2 15.5 1.21 0.0004 10536746 Arf5 740.7 41.8 898.9 38.1 1.21 0.0236 10581499 Chtf8 611.1 39.7 741.6 17.9 1.21 0.0246 10429699 Scrib 220.1 12.6 267.1 1.1 1.21 0.0153 10477012 Fkbp1a 374.0 7.4 453.8 15.9 1.21 0.0042 10515536 Ipo13 236.1 4.9 286.4 5.6 1.21 0.0018 10563558 Sergef 143.3 5.3 173.8 4.8 1.21 0.0075 10392735 Cdc42ep4 149.2 6.2 180.8 12.7 1.21 0.0302 10607497 Suclg2 396.2 26.7 480.1 6.7 1.21 0.0254 10528038 Adam22 125.2 6.4 151.7 10.4 1.21 0.0358 10569583 Ppfia1 276.1 0.9 334.4 25.2 1.21 0.0220 10394124 B3gntl1 118.5 8.5 143.5 2.8 1.21 0.0311 10395414 Tmem195 435.5 30.1 527.4 29.3 1.21 0.0434 10449854 Akap8l 169.4 13.7 205.1 0.4 1.21 0.0398 10590343 Trak1 274.4 8.1 332.3 23.5 1.21 0.0246 10398907 Pld4 1785.0 96.0 2161.4 25.2 1.21 0.0140 10393058 H3f3b 3085.2 107.2 3735.8 258.1 1.21 0.0259 10445601 Mea1 383.7 25.7 464.5 8.7 1.21 0.0263 10370508 Gm9978 127.9 1.7 154.8 8.8 1.21 0.0114 10604735 Rbmx 437.3 18.4 529.1 29.6 1.21 0.0215 10520154 Abcb8 132.8 7.4 160.7 10.6 1.21 0.0382 10561388 Timm50 284.5 21.5 344.1 0.8 1.21 0.0339 10468159 Ldb1 340.8 16.3 412.2 22.4 1.21 0.0244 10531208 Cox18 309.1 13.4 373.6 4.3 1.21 0.0080 10353934 Actr1b 361.5 13.1 437.0 0.2 1.21 0.0045 10540579 Mtmr14 389.9 29.8 471.3 15.6 1.21 0.0414 10564736 Polg 201.0 2.3 242.9 1.5 1.21 0.0002 10408902 Ccdc90a 487.1 20.5 588.6 20.4 1.21 0.0122 10370610 Polrmt 192.8 8.5 232.9 9.5 1.21 0.0157 10446074 Uhrf1 160.8 6.4 194.1 12.9 1.21 0.0278 10578193 Eri1 334.6 20.8 403.8 5.8 1.21 0.0221 10405236 Sfxn1 403.8 16.0 487.1 5.9 1.21 0.0066 10535532 Tecpr1 293.3 12.5 353.9 11.3 1.21 0.0120 10413100 Myst4 206.8 6.7 249.3 18.2 1.21 0.0295 10517425 Lypla2 661.6 41.5 796.9 24.4 1.20 0.0273 10561017 Pafah1b3 179.8 13.0 216.5 11.7 1.20 0.0495 10588429 Pik3r4 256.2 11.9 308.5 7.8 1.20 0.0129 10514830 Ttc4 196.4 10.6 236.4 10.3 1.20 0.0250 10470322 Surf2 222.7 3.7 267.7 3.1 1.20 0.0008 10518428 Clcn6 181.9 1.5 218.6 10.5 1.20 0.0074 10499394 Lmna 1007.9 47.9 1210.0 36.6 1.20 0.0155 10524105 Chfr 413.1 25.0 495.8 11.9 1.20 0.0245 10444268 Tap2 243.9 13.4 292.7 16.1 1.20 0.0337 10406198 Ftl2 10252.9 269.8 12300.8 563.0 1.20 0.0106 10401519 Npc2 1310.6 106.2 1571.8 12.4 1.20 0.0461 10371141 Hmg20b 247.4 5.7 296.6 20.1 1.20 0.0230 10377541 Lsmd1 332.0 18.0 397.9 0.7 1.20 0.0161 10346576 Stradb 157.5 4.7 188.7 3.8 1.20 0.0044 10530612 Fryl 372.0 22.2 445.7 29.7 1.20 0.0482 10509645 Ubr4 470.4 25.7 563.3 8.3 1.20 0.0179 10394209 Dnmt3a 292.7 21.5 350.4 4.5 1.20 0.0378 10373810 Dusp18 135.3 8.2 161.9 9.0 1.20 0.0414 10478219 Plcg1 200.2 13.0 239.6 0.0 1.20 0.0271 10392261 Smurf2 484.3 27.6 579.4 21.7 1.20 0.0274 10412981 Sec24c 835.9 17.4 999.8 48.5 1.20 0.0106 10448563 E4f1 234.5 7.6 280.3 8.1 1.20 0.0075 10431352 Tubgcp6 134.7 6.4 160.9 2.3 1.20 0.0130 10572332 Sfrs14 195.8 5.6 234.0 8.6 1.19 0.0085 10352242 Parp1 351.7 20.2 420.1 22.7 1.19 0.0381 10461898 Rfk 523.0 10.6 624.5 23.3 1.19 0.0061 10508420 Yars 310.7 12.7 370.8 11.1 1.19 0.0125 10496756 Mcoln3 1930.0 58.9 2301.7 130.0 1.19 0.0197 10461257 Ubxn1 454.1 17.5 541.4 38.0 1.19 0.0353 10430825 Cenpm 113.8 5.4 135.7 0.7 1.19 0.0123 10363350 P4ha1 492.6 22.7 587.2 41.5 1.19 0.0419 10557211 Rbbp6 158.9 6.8 189.4 2.9 1.19 0.0103 10572622 Gtpbp3 114.0 6.5 135.9 8.8 1.19 0.0474 10417972 Camk2g 443.8 24.5 528.9 37.0 1.19 0.0499 10443764 Slc37a1 162.5 1.6 193.6 4.6 1.19 0.0014 10478560 Dnttip1 327.3 12.3 390.0 11.0 1.19 0.0103 10597978 Fyco1 242.7 6.1 289.1 19.7 1.19 0.0263 10535841 Slc46a3 162.4 5.9 193.4 14.7 1.19 0.0403 10527624 Uspl1 298.6 10.3 355.5 8.1 1.19 0.0074 10358733 Rgl1 448.3 17.3 533.7 9.2 1.19 0.0085 10506843 Cc2d1b 213.9 4.0 254.5 10.2 1.19 0.0070 10461671 Patl1 511.1 11.6 608.2 30.3 1.19 0.0128 10382542 Nup85 225.5 8.6 268.3 9.8 1.19 0.0139 10500069 Pip5k1a 266.8 11.8 317.3 5.1 1.19 0.0119 10579277 Klhl26 150.2 4.0 178.7 14.7 1.19 0.0416 10459534 Afg3l2 356.8 24.2 424.2 5.8 1.19 0.0345 10466423 Cep78 138.5 10.9 164.6 0.6 1.19 0.0483 10424853 Brp16 116.3 3.1 138.1 10.3 1.19 0.0345 10539822 Copg 501.6 9.6 595.7 4.0 1.19 0.0011 10392990 Grb2 674.1 18.0 800.2 13.6 1.19 0.0037 10356423 Usp40 174.5 9.5 207.1 5.2 1.19 0.0231 10457729 Dsc1 183.2 2.9 217.4 18.4 1.19 0.0414 10551760 Zfp84 468.3 16.7 555.6 41.9 1.19 0.0411 10499620 Flad1 106.7 5.4 126.6 8.5 1.19 0.0462 10446402 Ppp4r1 638.0 33.4 757.0 8.0 1.19 0.0181 10371356 Appl2 332.7 15.7 394.7 6.5 1.19 0.0148 10445422 Slc35b2 146.4 8.4 173.7 3.0 1.19 0.0242 10369413 Sgpl1 1977.1 86.6 2344.5 105.9 1.19 0.0231 10563362 Sphk2 246.5 5.4 292.3 1.4 1.19 0.0015 10571325 Mfhas1 210.5 14.7 249.5 5.3 1.19 0.0408 10564909 Man2a2 517.3 35.3 613.3 10.6 1.19 0.0376 10375079 Ubtd2 155.7 10.5 184.6 0.6 1.19 0.0350 10580516 Gm6625 354.3 19.5 419.8 18.2 1.18 0.0328 10402730 Ppp1r13b 141.4 6.0 167.5 10.5 1.18 0.0353 10422185 Rnf219 142.7 9.0 169.0 1.1 1.18 0.0296 10550527 Irf2bp1 168.5 8.3 199.6 14.0 1.18 0.0483 10359235 Rasal2 149.6 1.3 177.1 14.3 1.18 0.0365 10581036 Tk2 224.2 16.7 265.3 3.5 1.18 0.0469 10450296 Skiv2l 353.2 20.5 418.0 16.2 1.18 0.0343 10554419 Vps33b 302.3 8.7 357.7 11.8 1.18 0.0087 10554574 Tm6sf1 2895.0 73.5 3422.5 217.1 1.18 0.0253 10447361 Ttc7 650.7 32.5 769.2 20.8 1.18 0.0210 10382022 Ccdc44 179.2 2.3 211.7 17.5 1.18 0.0406 10421661 Gtf2f2 176.0 4.2 207.9 15.6 1.18 0.0359 10543944 Mtpn 1937.8 70.2 2289.1 160.8 1.18 0.0387 10539741 Aak1 243.0 11.9 287.0 10.7 1.18 0.0249 10517173 Ccdc21 122.6 6.2 144.8 5.1 1.18 0.0252 10606744 Rps2 3888.2 150.7 4590.3 359.7 1.18 0.0498 10375103 Fbxw11 253.2 9.2 298.9 14.3 1.18 0.0208 10444524 Ehmt2 479.7 27.2 566.2 25.3 1.18 0.0377 10471844 Nek6 891.2 35.4 1051.8 46.2 1.18 0.0208 10345715 Map4k4 249.2 7.7 294.1 14.7 1.18 0.0189 10600341 Emd 304.5 19.1 359.2 5.0 1.18 0.0326 10460057 Tshz1 168.1 5.6 198.2 15.9 1.18 0.0485 10393272 Rnf157 130.9 8.2 154.3 7.7 1.18 0.0495 10572838 Sin3b 336.6 19.9 396.4 15.7 1.18 0.0390 10381345 Psme3 705.1 1.1 830.1 5.8 1.18 0.0000 10480971 Snapc4 140.1 7.9 164.9 0.1 1.18 0.0247 10480605 Cobra1 320.2 7.7 376.9 20.4 1.18 0.0189 10379901 Bcas3 220.2 7.7 259.2 19.9 1.18 0.0469 10526014 Sfrs8 205.6 5.0 242.0 8.4 1.18 0.0080 10387536 Cd68 5995.1 258.7 7054.9 328.0 1.18 0.0264 10465587 Fermt3 647.1 45.7 761.1 17.7 1.18 0.0482 10517147 Dhdds 560.4 31.2 659.1 9.3 1.18 0.0253 10600786 Klhl15 140.0 8.4 164.6 2.2 1.18 0.0307 10524723 Gcn1l1 223.4 4.5 262.7 2.8 1.18 0.0017 10576305 Tcf25 1218.2 31.1 1432.2 58.0 1.18 0.0114 10434067 Smpd4 196.2 5.7 230.6 14.7 1.18 0.0299 10485081 Dgkz 393.4 26.8 462.1 3.2 1.17 0.0416 10378681 Inpp5k 609.1 36.2 715.3 28.3 1.17 0.0410 10516859 Ythdf2 293.5 10.4 344.6 21.0 1.17 0.0323 10532720 Sart3 154.9 1.5 181.8 0.7 1.17 0.0002 10374348 Gm12009 581.8 8.1 682.8 46.6 1.17 0.0280 10433721 Nde1 278.3 10.8 326.4 7.1 1.17 0.0123 10587266 Gclc 367.3 16.9 430.4 28.6 1.17 0.0488 10531752 Helq 117.4 1.4 137.6 4.9 1.17 0.0053 10349348 Ccdc93 216.8 3.1 254.0 12.7 1.17 0.0133 10517243 Pdik1l 120.8 1.4 141.5 0.8 1.17 0.0004 10450519 Tcf19 220.5 8.3 258.1 16.3 1.17 0.0377 10349782 Nuak2 615.2 22.7 719.9 11.4 1.17 0.0101 10486469 Vps39 579.6 23.3 678.1 24.5 1.17 0.0199 10418410 Prkcd 1399.1 87.7 1636.5 31.4 1.17 0.0389 10348180 Eif4e2 305.9 3.8 357.7 24.3 1.17 0.0292 10576160 Acsf3 118.9 7.4 139.0 0.5 1.17 0.0356 10547034 Raf1 963.8 49.5 1126.7 41.9 1.17 0.0323 10537911 Zfp398 160.1 4.2 187.1 5.2 1.17 0.0074 10456622 Mbd1 321.1 13.3 375.0 20.2 1.17 0.0341 10464728 Kdm2a 484.5 23.7 565.8 12.6 1.17 0.0230 10375903 Cdkn2aipnl 716.9 50.1 837.0 2.3 1.17 0.0488 10372060 Cradd 125.4 6.7 146.4 7.9 1.17 0.0481 10486595 Ttbk2 156.1 9.5 182.2 7.4 1.17 0.0481 10358064 Ipo9 486.0 21.3 566.9 11.1 1.17 0.0173 10444578 Neu1 693.4 35.6 808.7 19.4 1.17 0.0271 10370837 Tcfe2a 293.1 9.9 341.7 24.7 1.17 0.0477 10427205 Myg1 221.5 1.6 258.1 13.1 1.17 0.0137 10548180 Itfg2 134.9 6.7 157.1 5.9 1.16 0.0321 10397281 Ylpm1 304.5 16.7 354.5 16.3 1.16 0.0455 10516721 Gm12967 156.9 5.2 182.7 6.4 1.16 0.0156 10415608 Ift88 144.8 4.7 168.6 7.4 1.16 0.0201 10494735 Gdap2 475.8 14.6 553.4 41.3 1.16 0.0499 10392183 Ern1 296.6 19.0 344.9 5.5 1.16 0.0442 10430997 Pacsin2 419.9 23.8 488.1 16.4 1.16 0.0407 10392970 Mif4gd 206.9 10.0 240.5 0.5 1.16 0.0206 10353803 Uggt1 711.3 27.0 826.5 2.1 1.16 0.0107 10369774 Nrbf2 229.3 8.2 266.4 12.6 1.16 0.0262 10362892 Magmas 196.9 7.6 228.2 9.0 1.16 0.0239 10457961 Sft2d3 148.6 7.3 172.2 6.4 1.16 0.0348 10354979 Als2 239.5 12.0 277.6 4.4 1.16 0.0258 10484999 Ddb2 125.9 3.0 145.8 3.1 1.16 0.0055 10439471 Ktelc1 313.6 19.4 362.9 7.4 1.16 0.0461 10467041 Asah2 109.0 4.8 126.1 2.9 1.16 0.0218 10509601 Tmco4 199.4 9.3 230.5 6.8 1.16 0.0283 10593205 Rexo2 1797.7 93.0 2078.3 68.1 1.16 0.0369 10432215 Ddx23 335.8 15.1 388.0 20.8 1.16 0.0448 10527340 Trrap 300.7 16.3 347.4 15.1 1.16 0.0485 10550935 Xrcc1 195.5 11.1 225.8 6.3 1.15 0.0422 10481023 Sec16a 319.0 15.6 368.4 1.2 1.15 0.0241 10517383 Nipal3 194.1 10.7 224.0 4.7 1.15 0.0367 10491279 Prkci 310.6 7.4 358.5 13.0 1.15 0.0122 10362210 Med23 362.6 9.1 418.1 15.2 1.15 0.0132 10558847 Phrf1 294.6 13.3 339.4 2.8 1.15 0.0207 10415642 Sap18 128.3 7.0 147.8 1.1 1.15 0.0341 10581073 Dync1li2 389.6 9.7 448.8 3.6 1.15 0.0042 10568282 Bcl7c 154.2 9.0 177.6 4.3 1.15 0.0455 10518069 Efhd2 840.7 29.2 968.2 1.7 1.15 0.0100 10545417 Mat2a 1327.6 64.5 1528.4 38.1 1.15 0.0309 10452648 Emilin2 344.1 4.5 395.9 13.3 1.15 0.0069 10397311 Dlst 580.2 14.4 667.5 2.7 1.15 0.0040 10511084 Nadk 1091.1 37.6 1254.1 29.3 1.15 0.0146 10560551 Sfrs16 192.7 7.3 221.5 9.8 1.15 0.0315 10427704 Dnajc21 134.3 6.0 154.3 3.6 1.15 0.0265 10463282 Entpd7 165.9 4.9 190.4 12.2 1.15 0.0455 10405822 Ccrk 106.5 5.4 122.2 0.0 1.15 0.0295 10508663 Laptm5 9447.2 426.2 10834.9 69.3 1.15 0.0226 10380534 Spop 982.8 43.9 1126.9 29.2 1.15 0.0283 10401365 Zfyve1 296.5 10.7 339.8 12.5 1.15 0.0250 10526726 Zkscan1 235.9 12.8 270.3 7.6 1.15 0.0447 10535189 Mad1l1 186.2 2.9 213.3 2.4 1.15 0.0017 10476326 Cds2 629.3 16.4 719.9 34.0 1.14 0.0250 10582669 Ttc13 259.4 13.5 296.6 10.6 1.14 0.0479 10596967 Atrip 134.7 5.6 154.0 3.0 1.14 0.0233 10457508 Npc1 2022.0 90.7 2309.8 101.8 1.14 0.0445 10403361 Pitrm1 403.9 8.8 461.3 26.0 1.14 0.0325 10488892 Trpc4ap 909.8 29.5 1039.1 29.6 1.14 0.0173 10434094 Klhl22 122.6 6.3 140.0 4.1 1.14 0.0442 10535629 Pdap1 237.5 12.3 271.2 1.2 1.14 0.0352 10471018 Fam73b 145.9 4.8 166.4 4.0 1.14 0.0162 10410435 Pols 283.4 12.7 323.2 8.0 1.14 0.0314 10395005 Kidins220 779.1 35.6 888.1 0.9 1.14 0.0262 10376959 Elac2 329.8 18.1 375.9 7.0 1.14 0.0458 10437330 Crebbp 207.0 4.9 235.8 10.4 1.14 0.0221 10414093 Glud1 2372.2 129.5 2698.9 65.5 1.14 0.0498 10493394 Clk2 379.6 20.8 431.6 1.8 1.14 0.0441 10405741 Gm3338 663.4 23.3 754.1 4.0 1.14 0.0139 10532753 Coro1c 1963.7 47.1 2231.9 88.3 1.14 0.0193 10552210 Ankrd27 247.4 10.2 281.0 10.8 1.14 0.0385 10564938 Fes 564.1 16.5 640.5 2.1 1.14 0.0085 10392388 Prkca 139.2 4.4 158.1 4.6 1.14 0.0191 10534202 Ncf1 1706.8 94.9 1937.5 10.0 1.14 0.0473 10475247 Tmem62 178.1 4.8 202.0 4.5 1.13 0.0112 10436734 Bach1 603.9 25.8 684.1 8.9 1.13 0.0270 10563275 Ruvbl2 251.3 9.9 284.0 2.4 1.13 0.0224 10452404 Nudt12 114.3 2.3 129.2 7.7 1.13 0.0433 10606026 Zmym3 163.6 7.9 184.5 2.8 1.13 0.0408 10500133 Prune 120.6 4.9 136.0 1.2 1.13 0.0251 10596041 Il20rb 176.7 7.3 199.3 1.2 1.13 0.0261 10389293 Mrm1 174.2 4.0 196.4 6.0 1.13 0.0144 10405971 Nsun2 346.9 6.3 391.1 0.6 1.13 0.0026 10597575 Plcd1 131.0 2.5 147.7 1.0 1.13 0.0034 10430941 Rrp7a 302.8 11.4 340.9 1.1 1.13 0.0209 10347106 Rpe 298.7 4.0 336.3 11.0 1.13 0.0102 10495359 Clcc1 493.7 13.7 555.2 20.5 1.12 0.0257 10532965 Rnf10 960.8 16.7 1079.8 13.1 1.12 0.0036 10479794 Prpf18 220.5 2.6 247.4 15.2 1.12 0.0470 10461568 Prpf19 368.5 7.0 413.5 3.8 1.12 0.0040 10348924 Gm15427 5427.1 107.3 6088.9 253.8 1.12 0.0239 10592618 Tbcel 244.6 9.8 274.4 11.1 1.12 0.0497 10443063 Phf1 244.0 8.5 273.7 7.7 1.12 0.0292 10592067 Fli1 557.0 4.3 624.7 32.6 1.12 0.0305 10558441 Mgmt 138.2 5.5 154.9 6.2 1.12 0.0499 10498775 Golim4 154.0 3.3 172.6 5.1 1.12 0.0144 10413222 Ppif 109.1 3.8 122.1 5.4 1.12 0.0476 10575129 Vps4a 285.1 4.1 319.0 12.5 1.12 0.0187 10385557 Cnot6 324.8 7.6 363.2 6.0 1.12 0.0097 10346533 Nif3l1 207.6 6.4 231.9 8.4 1.12 0.0334 10446376 Man2a1 928.0 35.9 1035.3 15.4 1.12 0.0311 10347232 Xrcc5 552.1 23.1 615.8 17.6 1.12 0.0471 10424439 Efr3a 616.1 13.9 686.9 27.3 1.11 0.0281 10547769 Ptpn6 2037.3 78.8 2271.3 35.8 1.11 0.0321 10536429 Tmem106b 447.8 15.6 499.3 10.0 1.11 0.0277 10436694 Rplp0 5594.6 163.1 6231.5 255.5 1.11 0.0392 10579234 Upf1 322.2 13.3 358.8 2.7 1.11 0.0350 10470816 Gle1 285.2 11.9 317.4 8.9 1.11 0.0494 10459158 Hmgxb3 198.3 7.5 220.6 4.6 1.11 0.0352 10419779 Haus4 149.5 6.0 166.3 0.4 1.11 0.0332 10347460 Ttll4 246.9 2.7 274.4 3.4 1.11 0.0020 10378482 Mett10d 229.9 2.5 255.3 14.4 1.11 0.0473 10393047 Galk1 122.6 1.9 136.2 0.9 1.11 0.0027 10556280 Swap70 196.9 6.6 218.5 3.7 1.11 0.0267 10534974 Mcm7 390.3 7.6 432.8 14.7 1.11 0.0213 10364262 Itgb2 5708.1 208.9 6325.9 108.4 1.11 0.0337 10346943 Creb1 417.9 14.0 463.0 4.8 1.11 0.0246 10581523 Terf2 216.9 9.0 240.2 4.0 1.11 0.0450 10390271 Nfe2l1 766.3 11.5 847.8 38.2 1.11 0.0338 10585249 Ppp2r1b 844.0 25.7 933.4 27.5 1.11 0.0337 10597748 Gorasp1 142.1 3.6 157.1 5.7 1.11 0.0335 10594835 Grinl1a 256.1 5.6 283.0 4.4 1.11 0.0112 10461497 Ddb1 1461.6 26.1 1615.0 15.5 1.10 0.0054 10461274 Ints5 168.8 3.1 186.2 5.6 1.10 0.0182 10551666 Map4k1 408.8 15.9 451.0 1.8 1.10 0.0378 10492381 Gmps 497.5 17.6 548.7 3.2 1.10 0.0305 10445640 Trerf1 497.6 7.9 547.9 17.7 1.10 0.0199 10366712 Ppm1h 371.0 7.5 408.2 16.9 1.10 0.0381 10476969 Pygb 261.4 7.9 287.6 0.5 1.10 0.0213 10412100 Map3k1 396.0 1.9 435.2 9.9 1.10 0.0054 10484894 Ptprj 473.1 6.9 519.9 15.0 1.10 0.0157 10434252 Hira 195.3 2.4 214.1 0.1 1.10 0.0019 10582642 Taf5l 134.0 1.7 146.8 5.2 1.10 0.0240 10591357 Eif3g 341.9 7.7 374.2 3.8 1.09 0.0132 10446109 Safb 391.6 7.0 428.2 2.8 1.09 0.0066 10569071 Hras1 172.8 1.2 188.8 4.6 1.09 0.0088 10581800 Rfwd3 332.9 7.7 362.6 6.9 1.09 0.0221 10545644 Wbp1 314.4 6.8 342.0 4.8 1.09 0.0166 10425066 Csf2rb 2496.0 72.3 2693.5 50.7 1.08 0.0464 10436402 Cldnd1 816.1 25.6 879.7 2.5 1.08 0.0447 10357249 Steap3 133.0 2.0 143.2 5.3 1.08 0.0492 10527896 Ankib1 385.0 11.0 413.8 6.7 1.07 0.0480 10400254 Heatr5a 723.2 19.4 776.6 1.8 1.07 0.0350 10514221 Plin2 6609.6 128.6 7028.0 148.0 1.06 0.0429 10428648 Taf2 308.3 3.7 327.7 5.2 1.06 0.0160 10517141 Hmgn2 3507.3 37.0 3719.4 33.7 1.06 0.0075 10582337 Fam38a 406.5 6.6 430.6 2.4 1.06 0.0176 10380859 Crkrs 233.2 2.2 246.9 5.5 1.06 0.0253 10506031 Nfia 296.7 4.7 313.8 1.1 1.06 0.0169 10393021 Recql5 134.2 1.2 141.0 3.4 1.05 0.0427 10508759 Rpa2 206.7 2.5 214.5 1.5 1.04 0.0309