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Neuroscience Antibodies & Protocols (USA & European Edition) 2006 Neuroscience Antibodies & Protocols (U.S.A. & European edition) 2006 www.abcam.com Contents Welcome to Abcam About Abcam . .1 The team . .2 Neuroscience at Abcam . .2 Benefits of an Abcam account . .3 Neuroscience Abwire . .2 AbreviewsSM and Abcam AbpointsSM . .3 Abbreviations Catalogue contents Species key . .5 Applications key . .5 Neuroscience antibody categories Cell adhesion proteins Oxytocin & Vasopressin . .30 Cytoskeletal . .6 Thyroid Axis . .30 ECM . .8 Neuronal markers Membrane . .10 Glia . .31 Nuclear . .10 Neural Stem Cells . .33 Growth & development Neuron . .35 Axonal Guidance . .11 Neurotransmission Neurogenesis . .11 Calcium Signaling . .43 Neurotrophins . .12 Intracellular Signaling . .44 Notch Pathway . .13 Neurotransmitters . .47 Signal Transduction . .14 Neuropeptides . .50 Neurodegeneration Nitric Oxide . .52 Alzheimer’s . .18 Pharmacological Tools . .53 Huntington’s . .22 Receptors & Channels . .53 Parkinson’s . .22 Secretory Vesicles . .59 Prions . .24 Transporters . .61 Related Targets . .25 Sensory pathways Neuroendocrinology Hearing . .62 GH Regulation . .26 Nociception . .62 Gonadotrophic Axis . .26 Olfaction . .63 HPA Axis . .27 Touch . .63 Obesity & Metabolism . .28 Vision . .63 Technical help Neuroscience resources at Abcam . .64 Neuroscience protocols and tips . .66 Product datasheet guide . .65 Neuroscience signaling pathway diagrams . .85 Ordering and contact details Contact details . .89 Required Information for ordering . .89 Ways to order . .89 Abcam’s terms and conditions . .90 Coming soon New Neuroscience antibodies . .91 Target index Target index . .92 Ordering information: www.abcam.com | Tech support: www.abcam.com/technical Neuroscience resources: www.abcam.com/neuroscience Welcome to Abcam About Abcam Abcam, located in Cambridge, U.K. and Cambridge, MA, U.S.A., was founded in 1998 by Dr. Jonathan Milner, then a researcher at Cambridge University, U.K.: “Like many life science researchers, I was frustrated by the time it took to locate and select antibodies essential for my research. This was largely due to poor information and out-of-date catalogs from the vast range of suppliers who were spread across many countries. In some cases, I W also experienced difficulties with companies whose products were unreliable and whose customer elcome to service was slow and unhelpful. My vision was to build a company that offered reliable cutting-edge products and great customer service.” It was a tough vision - Abcam was created to sell the best antibodies in the world with the most comprehensive, honest and up-to-date datasheets, fast delivery, helpful customer service and comprehensive technical support. Abcam Seven years on and with thousands of products across our range, Abcam ships to scientists in over 55 countries around the world. Abcam is committed to the following fundamental principles that have seen us become the first choice for thousands of life-scientists throughout industry and academia: • Quality of products and datasheets • Helpful technical support and online technical resources • Friendly customer service • Fast delivery Comprehensive We have a policy of honesty - our customers know everything that we know about our products, as soon as we know it. Everything we know about each product is posted on the datasheet. To achieve exceptional levels of quality for our customers we provide: • Comprehensive datasheets. • Customers’ AbreviewsSM of our products . • Product-specific protocols used by our customers. • Customers’ technical questions and our answers for each product. • Product information and new products updated daily. ...all at www.abcam.com! Helpful Our Technical Support and Customer Service departments are full of scientists that have many years of experience working with the types of products that we supply to our customers. We provide continuous order progress updates, so that you always know what is happening with your order and when you should expect to receive it. The Queen's Award for Enterprise The Queen's Award for Enterprise has been running since 1966 and is widely recognised as the premier award for business performance in the UK; granted annually for outstanding business achievement. Abcam demonstrated excellent year-on-year growth in overseas sales between 2002 and 2004 with 84% of sales during these three years coming from overseas customers. The award is positive proof of the company's outstanding success as a customer-focused international business. Customer Service Tel: Europe +44 (0) 1223 696000 | U.S.A. 1 617 225 2272 (Toll free: 1 888 77 ABCAM) 1 Free services The World’s Antibody Gateway search engine If we do not have the product that you are looking for use this service to search all online catalogs of other antibody suppliers. Find the “WAG” at: www.abcam.com/antibodygateway The Abcam Toolbar Directly search your choice of Abcam, GenBank, Google, LocusLink, OMIM, PubMed, SWISSProt. The toolbar sits within your internet browser, so that you can use it from wherever you are on the internet. Get this useful facility at: Abcam www.abcam.com/toolbar Fast elcome to W We have developed web-based systems that enable us to quickly identify cutting-edge products, make them rapidly available to our customers and then deliver them by Express Delivery. We are pleased to be able to offer next-day delivery to all major cities as well as same day delivery to customers in Cambridge U.K. and Cambridge MA, U.S.A. Neuroscience at Abcam Our range of over 2,000 Neuroscience primary antibodies has a breadth and depth that is hard to beat. Further more, we collaborate with leading academics to make the Abcam range one of the best in the world! The Neuroscience Abwire Our Neuroscience Abwire web page is full of exclusive articles, product browsing tools, conference and publication information and specialist protocols. Visit today for cup-to-date information in this rapidly progressing field. Look out for new Neuronal Marker IHC Galleries, Neurodegeneration and Neurotransmission signaling pathway diagrams and Neuroscience Product Locator tools (to name but a few). Visit: www.abcam.com/neuroscience for more. The Neuroscience team Abcam has a specialized team working on sourcing and testing the best Neuroscience antibodies available. Our background in the neurosciences is very strong to better serve our customers. Members include: Technical Support Sarah and Bill help customers Sarah Mardle (PhD King’s College, University of London, U.K.) who have enquiries about, or Technical Support Manager (U.K.) problems with, Abcam antibodies using their extensive PhD and postdoctoral laboratory experience.They also: • Attend conferences to keep up-to-date with antibody Bill Campbell (PhD Brown University, U.S.A.) techniques and research Technical Support Manager (U.S.A.) • Source new protein targets • Source novel techniques using antibodies • Build collaborations with academics. Ordering information: www.abcam.com | Tech support: www.abcam.com/technical 2 Neuroscience resources: www.abcam.com/neuroscience Neuroscience at Abcam The Neuroscience team Business Development Sabrina Edmonds (PhD University of Cambridge, U.K.) Business Development Manager for Neuroscience W Sabrina is responsible for sourcing new and exciting protein targets to generate antibodies against by elcome to attending conferences, forging collaborations with academics and by reading current literature. She is the main contact for academics who are interested in licensing their neuroscience antibodies for sale through Abcam. Marketing Abcam Rhian Hayward (PhD University of Oxford, U.K.) Neuroscience Marketing Manager Rhian is responsible for marketing Abcam’s Neuroscience range to our customers worldwide. She ensures that Abcam supports many Neuroscience community activities through conference sponsorships, informative marketing materials e.g. signalling pathways (see page 83), the Neuroscience Abwire and more. Suggestions or comments: Email the team at [email protected] Benefits of an Abcam Account Take full advantage of all our online Neuroscience resources by opening an account. • Earn Abcam AbpointsSM • Buy quickly and efficiently online. • Customise your antibody updates. We can notify you by email of new and updated antibodies related directly to the protein families which interest you. SM Abreviews Our unique system for enabling our customers to feedback to you and us about the performance of our primary antibodies. It is important to know how our antibodies perform under different conditions and that they are working as expected. We encourage this feedback (positive and negative) by awarding AbpointsSM for each Abreview: AbreviewTM Action Points Description Submit an Abreview 50 Each unique combination of antibody, application and sample species that you review, earns you Abcam AbpointsSM, e.g. if you use one of our antibodies in WB on Human and Mouse samples and submit an Abreview for both these combinations, then you will receive 50 Points for each one. Submit an Abreview 200 As for “Submit an Abreview” but for an antibody that has not yet been tested in (untested application / that particular species or application. species) Submit an image with your 100 If you submit an image to accompany any of your Abreviews, then you will Abreview receive extra Points when it is published with your Abreview. For Abreview and image publication criteria, please see the Abreviews section of our website. st Fast Track Abreviews 950 Be the 1 researcher to submit conclusive positive or negative data (through bonus
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