R a Still The Second Best Thing About Payday

Pilot Program Invites Hispanic . HIGHLIGHTS Cordial Tone Set for New Chair Participants Zerhouni Welcomed, Kirschstein By Constance Burr ,Sufre de transtorno bipolar o de New Director Lauded at 84th ACD Meeting depresi6n7 , Le interesa participar en una Meets Advisors investigaci6n clinical A bilingual pilot By Carla Garnett ust moments after 8:30 a.m. on June 6 and a scant 2½ weeks program is advertising in Spanish, Social Inequalities after his first day on the job, new NIH recruiting people with bipolar disorder or A Barrier to Health director Dr. Elias Zerhouni was for­ major depression for screening and clinical J trials conducted in Spanish at the National mally handed the gavel at the 84th meeting Institute of Mental Health. of rhe advisory committee to the director Diggs Lecture Set, (ACD), which he now chairs as head of the July 15 agency. To strengthen Hispanic participation in "I think we should have a ceremony that research studies, Dr. Carlos Zarate, Jr., chief allows Dr. Zerhouni's previous home of the mood disorders research unit, is Free Summer Film Festival institution to turn the gavel over to our new directing trials with Spanish protocols and chairman," said NIH deputy director Dr. bilingual doctors, nurses, social workers Ruth Kirschstein, who had chaired the and technicians. He is also getting the twice-yearly ACD meetings as acting NIH lntraMall Event word out to the public. Because many in director since 2000. She called on ACD the Hispanic community prefer radio Shows Products member Dr. William Brody, president of D h . ACD programs and advertising in Spanish, radio o h ns H op km. s U111vers1 . .t y, to mtro. d uce r.· 2 er oum at spots and print ads reach a new audience J Zerhouni to the 36-year-old gathering of physicians, researchers, SEE HISPANIC PROGRAM, PAGE 2 NIH'ers Race for lawyers, professors and business executives that assembles on the Cure 2002 M ini-Med School SEE ACD MEETING, PAGE 6 NIH Educates Public on the 'Biosocial' Approach to Public Health Science of Life Farmer Warns of Pathogen: Social Inequalities By Cynthia Delgado By Rich McManus With fears heightened by Sept. 11 events r. Paul Farmer embodies a. number of interesting p_aradoxes and daily news headlines about bioterrorist D that make him a provocatrve speaker and a thorn m the threats, antibiotic-resistant bacteria, and conscience of public medicine. Tall, emerging and re­ clean-cut and patrician, with a rapid­ emerging infectious fire, fact-backed speaking style- "Next diseases, the Office slide, please"- that would certainly of Science Education have served him well had he elected a introduced a new career on Wall St., he is as at home in an theme for its Spring overcrowded Siberian prison or the 2002 NIH Mini-Med slums of Haiti or Lima, Peru, as he is in School program: U.S. Department the halls of Brigham and Women's Dangerous Mi­ of Health and Hospital in Boston, where he also crobes: Emerging Human Services practices medicine as a Harvard profes­ and Re-emerging :--lation,11 lns1i111tcs sor. In fact, he says, the people are Mini-med stude11t Infectious Diseases of I lc.tlth sometimes friendlier in impoverished Kellie Campbell and Bioterrorism. rural Haiti than they are in Washington loved the course. The 6- to 8-week June 2.'i, 2002 or Geneva, from which he flew in the night before giving a lecture SEE MINI-MED SCHOOL, PAGE 4 Vol. LIV, No. 13 SEE FARMER. PAGE 8 HISPANIC PROGRAM, CONTINUED FROM PAGE 1 of potential patients. Ads from the mood disorders helping the Hispanic community participate in the program call for volunteers on WACA 1540 AM­ life of the country," said Saavedra. "The trials offer Radio America, a local Hispanic station, and in El Hispanic Americans and Latin American immigrants Pregonero, a weekly newspaper, which together the opportunity to invest in a network of health serve a market of some 400,000 Spanish speakers in care, education, and access to therapies." the metropolitan Washington area. The project is currently recruiting another essential With 80 calls from prospective subjects during the team member, a bilingual clinical studies representa­ first 2 weeks of advertising, the program's voice mail tive tO approach the Hispanic community, invite capacity had to be increased. "The Spanish­ Children with subjects, screen patients and consult with other speaking community is willing to take part because research branches on protocol consent, IRB involve­ ADHD Needed language and cultural barriers have been lowered," ment, bioethics and customer satisfaction. The Pediatric and Zarate said. "It's a "My goal for these studies is tO broaden scientific Developmental matter of trust. People knowledge and increase Hispanic participation," Neuropsychiatry feel we know where they Zarate said. Recruitment ads in English are also Branch, NIMH, are coming from." appearing in the Washington Post, the Gazette and seeks boys and On the air, announcers in fliers in movie theaters and health care facilities. girls 6 to 13 years invite listeners suffering In addition to promoting clinical trials to local of age, diagnosed from mood disorders to audiences, Zarate is aiming for Hispanic representa­ with attention enroll in studies that tion nationwide. He has spoken about the need for deficit hyperactiv­ offer medical and Latino volunteers at the Rocky Mountain College ity disorder psychiatric evaluations, Physician Assistants Program in Billings, Montana; (ADHD),to treatment, and transpor- Ponce Medical School, in Ponce, Puerto Rico; the , tation at no cost. University of Massachusetts, Worcester; and the participate in a Dr. Carlos Zarate, Jr. "C It . C . movement study. onsu ono omum- Office of Mental Health, New York City. This Volunteers should tario," a public forum on health with Dr. Elmer summer he plans to address Latino physicians of have no history of Huerta, and "Informativo Mundial," morning and Puerto Rico, continental U.S., and Latin America in other medical or afternoon newscasts, run the ads on weekdays. Miami, and mental health organizations in Texas. neurological "Calentando La Mariana," a morning drive talk In Census 2000, of 281.4 million residents counted disorders (includ­ show, showcases personalities of Hispanic interest. in the U.S., 35.3 million, or 12.5 percent were ing seizures and In a recent interview with popular host Madeline Hispanic, the nation's largest racial or ethnic hearing problems), Portalatin, Zarate explained symptoms of depres­ minority group. By targeting Spanish speakers in and should not be sion and bipolar disorder, the need to recognize and clinical trials, NIMH is using a strategy that affirms taking any diagnose these illnesses, and various kinds of its commitment to boosting minority participation in prescribed therapy. The benefits of research and treatment help health research. Ill medications. dispel stigma and improve lives across cultures, he Participation explained. Zarate encouraged listeners to call involves neurologi­ NIMH for a voice message in Spanish on how to cal examinations, take part. single and paired­ Two protocols have been translated into Spanish. N I H R f 0 R a These trials are testing new uses for established pulse TMS tests, Published biweekly ar Bcrhesda, Md., b)' the Editorial Operadons and hearing tests. drugs that cause changes in the brain similar to Brdnch, Dh•ision of Public lnformatiou, for the information of Participants w ill be antidepressants. In both studies, PET scans com­ employees of the National Institutes of Health, Deparrment of Health and Human Services. The content is reprintable without compensated for pare brain activity in healthy controls and those permission. Pictures ma)' be available on request. Use of funds for their effort and with mental disorders. printing this periodical has been approved by the director of the Office of Management and Budget through Sept. .30, 2002. time (approxi­ An outgrowth of the H ispanic Research Initiative, chaired by Dr. Juan Saavedra, chief, section on mately 3 hours). NIH Record Office Phone 496-2125 For more informa­ pharmacology, the comprehensive plan to engage Bldg. 31, Rm. 5B41 Fax 402-1485 tion, call Mark Spanish speakers in clinical trials sets the t0ne for Choa, 496-5323. future bilingual projects. The initiative steering Web address committee, comprising Saavedra, Zarate, Dr. http://www.nih.gov/news/NTH-Record/archives.hhn Catherine Roca and Dr. Jose Apud, advises the Editor The NIH Record reserves intramural program and institute director on Richard McManus rhe right to make outreach to the H ispanic community, translation [email protected] cocrections, changes, or and validation of forms and documents, Hispanic deletions in submitted Assistant Editor copy in conformity with patient recruitment for intramural research, and the Carla Garnett the policies of the paper necessity of having bilingual therapists in the [email protected] and HHS. studies. "This effort is part of a larger consideration- U Tl,e Record is rec,•clable as office white paper. Olufunmilayo F. Olopade, associate professor in NCRR Celebrates 40th Anniversary the department of medicine and director of the committee on genetics, Center for Clinical Cancer This month marks the 40th anniversary of the Genetics, University of Chicago Medical Center, National Center for Research Resources. While will deliver the eighth annual John Diggs Lecture, NCRR has undergone several transformations and slight name changes over the years, the sustaining sponsored by the NIH Black Scientists Association. goal has remained the same-providing the research Her lecture title is "Dissec­ resources that enable biomedical discovery. These tion of Cooperating resources extend across Genetic Pathways Involved biomedical research in Aggressive Early Onset · '' ;- I I r disciplines, to all of the Breast Cancer Reveals extramural programs of Mutually Distinct Roles for the NIH institutes, and BRCAl and HER-2/neu enable scientific advances Genes. " She has also been that lead to lifesaving asked to share any insights drugs, devices and she might have as to why therapies. NCRR is celebrating its black women dispropor­ anniversary with a special tionately die from breast edition of the NCRR cancer. The pr.ogram will Reporter, a quarterly be at noon on Monday, publication that is July 15 in Masur Auditorium, Bldg. 10, and is designed to foster cosponsored by the N IH Office of Research on ~ommunication, collaboration and resource-sharing Women's Health, the National Institute of Allergy in areas of current mterest to biomedical scientists. and Infectious Diseases, the National Institute of The spring issue highlights the importance of Neurological Disorders and Stroke, the National infrastructure support to advances in: studies of Human Genome Research Institute and the Na­ hypertension; organ transplantation; imaging tools tional Cancer Institute. The lecture is open to the and computers; mass spectrometry and stn:ictural biology; and identification of an AIDS-like virus in public. NIH summer students are encouraged to nonhuman primates. attend. Sign language interpretation will be pro­ The magazine can be found in kiosks in Bldgs. 1, vided. For reasonable accommodation, contact 10, 31 and 38A. Off-campus kiosks are located in Michael Chew at 402-3681, TTY Federal Relay the Federal Bldg., Executive Plaza North and Service 1-800-877-8339. Rockledge 1. The publication also can be accessed online at www.ncrr.nih.gov. EJ Free Summer Film Festival The Office of Science Education announces the Seminar on Alternat ives in Animal Research return of its free summer film festival, Science in the Cinema. Beginning July 11 for 6 consecutive weeks, NIH staff who write animal study proposals, or who are interested in a popular film with a medical science theme is searching the biomedical literature for procedural alternatives, are screened. Following each movie, an interactive encouraged to attend Alternatives in Animal Research. This free discussion with the audience is led by an expert on hands-on seminar is being offered at the NIH Library in Bldg. 1 Oon the subject depicted in the film. Thursday, July 11 from 1:30 to 3 p.m. Participants will be intro­ Shows begin at 7 p.m. each Thursday in Natcher duced to a checklist that guides researchers to resources that address auditorium, and seating is available on a first-come issues of reduction, refinement or replacement (the 3 R's) and can first-s~rved _basis. All films are shown with caption~; help meet Animal Welfare Act requirements. Resources covered Amencan Sign Language interpreters and real-time include databases available through the NIH Library web site such c~ptioning are provided for the post-film discus­ as: AGRICO~A, EMBASE via ScienceDirect, Psyclnfo, MEDLINE, s10ns. If other reasonable accommodation is and Web of Science. PORPOISE, a research update service developed required, contact OSE at least 5 days before each for NIH'ers, and PubMed's Cubby feature will also be discussed. film date at [email protected] or 402- Attendees will learn the advantages of working with librarians to 2470 (Federal Relay Service at 1-800-877-8339, perfor~ me~iated sear~hes in databases available through DIALOG. TTY users call 451-9706). No registration 1s requ1red, but attendees should arrive early at the Check the OSE web site at http://science. training room, lower level, to use a computer. Observers are wel­ education.nih.gov for this year's schedule and more com~. ~or more information, call the NIH Library at 496-1080 or event details. Ii) email Cmdy Clark at [email protected]. ---'

M INI-MED SCHOOL, CONTINUED FROM PAGE 1 program is offered each spring to the public, and moving, she finds it an excellent way co " lightly gives participants an idea of what it's like to be a touch base with what's happening in the field." Of medical student. A science background is not particular interest this year was the continuity that required, so lectures progressively build upon one ran throughout the courses. She said many issues another, beginning with the basic sciences and relating to infectious diseases were clarified for her culminating in more advanced topics. in each lecture. More motivated than ever "People should be beating down the doors to before to understand the attend these classes," noted ~tim-.Med student Kellie basic scientific principles that Campbell. She thought all the lectures were "phe­ shape the modern world, nomenal," especially OSE director Dr. Bruce Fuch's people rushed to sign up for class activity on herd immunity. Srudents were given the program. The school's an assignment to determine what percentage of the registration quota of 500 population should be students was met within 2 immunized to prevent the ~-i weeks of its announcement. spread of disease. She Mini-Med students agreed found the answer, 77 that the theme was both percent, starrling. " It was ~ timely and important, and the an epiphany for everyone major reason they signed up Mi11i-med classes there. \X'e understood for the course. satisfy Bruce Morton's how quickly disease can "I have a tremendous innate in11ate curiosit)' abor!t spread,~ she said. Re­ curiosity, and here is a world­ nature. garding \'accination, class institute offering the Campbell learned that opportunity to learn about microbiology," said "we do have weapons to p . k M Bruce Morton, a senior manager at fight the problems ... not atr,c urray Lockheed Martin in Virginia, and an only are we a part of the solution, but a very adjunct professor at George Washing­ important pare. " ton University. He explained that his .\1any prominent 1H scientists serve as Mini-Med interest stems from his early work as a school lecturers, despite their responsibilities and rocket scientist when he studied the busy schedules. Patrick Murray, chief of clinical ability of microbes to survive re-entry microbiology at the Clinical Center, is also an into the Earth's atmosphere. "I adjunct professor of pediatrics and pathology at the appreciate the time and resources the University of Maryland; a three-time winner of the NIH provides for this program," he Teacher of the Year award from Washington Univer­ added. One discovery for Morton was sity in Sc. Louis. and author of the bestselling the striking similarity between the textbook, Medical Microbiology. Using his exten­ structure and replication of a virus and sive background in academics as well as the labora­ how a computer "virus" infects and tory, he gave students a glimpse into the role a replicates itself within a system. clinical microbiology laboratory plays in the diagno­ Diana Mukitarian, who works in the sis, control and treatment of infectious diseases. NIH Small Business Office, says Mini­ Murray's successful style of teaching may stem Noreene Wells is a Med school brings science to the public on both a from his ability to relate to the audience, while repeat customer at " personal and professional level." With an educa­ limiting excess information and dispelling commonly the school. tion in behavioral science, she was able co revisit the held misconceptions. He said, "I try co take what's basic sciences and also gain a better perspective of mysterious about the laboratory and make it the new frontiers of science. She likes co take relevant." advantage of N IH resources, and believes it keeps For example, he talked about how bacteria's her in touch with NIH's mjssion-a goal important strange names often come from the names of to her work. She tries to portray this mission microbiologists discovering them. "The real skill," accurately when communicating with small busi­ he explained, "whether in writing or teaching is to nesses that wish co work with NIH. Before taking understand your audience and what they need to the course, she says she was scared of infectious know. You don't tell an audience everything you diseases, but now she is also comforted. "I better know." understand the challenge this nation is facing in Murray likes to start by giving a broad view of a biodefense." subject, and then narrowing the focus. In this case, Mini-Med student Noreene Wells has degrees in he gave Mini-Med students a look at the specialty both microbiology and zoology. This is her second areas of pathology and then the microbiology that year in the program. Because science is so fast- underlies the field. "Most people think of pathology as autopsies when, actually, a major component is lntraMall Holds Third Summer Showcase diagnostics." The much-anticipated lecture "Understanding the The NIH IntraMall will celebrate its third Summer Bio in Bioterrorism," presented by Dr. Anthony Showcase on Friday, June 28 at the Natcher Center. Fauci, director of NIAID, marked the culmination of The event, open to all employees, features many of the 2002 Mini-Med school program. He discussed NIH's largest laboratory and office supply vendors, the biological agents associated with bioterrorism; product demonstrations and lunchtime entertain­ gave an overview of the recent terrorist-initiated ment. The showcase opens at 10 a.m. with supplier outbreak of anthrax, its etiology and transmission· exhibits and continues through the day with a series and explained how NIH works with other govern-' of activities. ment agencies to prevent the spread of infectious Come learn about new products and features Healthy diseases, including the NIH strategic plan for making the IntraMaJI a popular service for online Children, biodefense research. purchasing and for the reconciliation of credit cards. Teens Needed He also spoke about his recent editorial in the New Pam Robbins, senior purchasing agent, and the England Journal of Medicine wherein he expresses IntraMall training team will be on hand to conduct NIMH is seeking the urgent need for dialogue between the public and demonstrations and answer questions. More than healthy children, government leaders on the debate about a nation­ 40 vendors representing over 2.5 million products in ages 6-17, to wide smaJlpox vaccination. The variola virus the the lntraMall will also be available to answer participate in a microbe responsible for smallpox, is of most ~oncern questions, demonstrate new products and learn how mood and because it is easily transmitted, has a high mortality they can better serve the NIH community. emotion study. rate, and the population lacks sufficient immunity. Among the vendors at the event are Sigma, Children may be Proponents of mass vaccination believe it would lnvitrogen, Fisher and VWR; computer and office eligible if they do eliminate the threat of smallpox as an agent of product companies like Micro/Mac Warehouse, Daly not have a history bioterrorism. Opponents are concerned with Computer, Office Depot, Corporate Express, of medical or vaccination's associated adverse effects. Matthews Medical Books; and Blind Industries psychiatric The NIH Mini-Med School serves the local Services of Maryland and BOSMA Industries for the problems or take community. However, there are more than 70 Mini­ Blind. any prescribed Med schools in the United States. Use the Mini-Med "The IntraMall is fast becoming the service of medications, or locator at http://science-education.nih.gov/minimed choice for those institutes and centers looking for an have first-degree to find other schools. Ill online ability to quickly and easily comply with relatives with Dr. Peter Greenwald, who has developed, nur­ reconciliation requirements," said Jeffrey Weiner, psychiatric tured, and quantified the field of cancer preven­ IntraMall project manager. "Early in our second problems. year of offering automated reconciliation, the tion, received the American Society of Clinical Participation IntraMall already accounts for over 25 percent of all involves a 3-day Oncology's 2002 American Cancer Society Award NIH credit card charge reconciliation activity." screening and at ASCO's annual meeting on May 18. He is "This is the third and hopefully best in our series evaluation, 2-day director of the Division of Cancer Prevention, of Summer Showcases at the NIH," said Dayle followup evalua­ NCI. The award is given Wilson, chief operating officer of the IntraMall. tion, and physi­ to an individual who has "We are thrilled with the full attendance from the ological and contributed significantly supplier community and hope that all our friends psychological to the prevention and and supporters come to the Natcher Center to enjoy testing. Compen­ control of cancer. As the exhibits, demonstrations and stay to relax with sation is provided. founding director of the the wonderful chamber music provided by Joel Call 496-8381 or Berman & Fr.iends before and after a complimentary Division of Cancer email bipolarc@ lunch." intra.nimh.nih.gov Prevention, he has Fresh from their lecture-performance series at the to volunteer or created and directed a Washington Conservatory of Music, Joel Berman & request more program of research that Friends will be performing selections from Haydn's information. incorporates not only Opus #64 and Beethoven's Opus #95 at 11:30 a.m. basic scientific investigations into early biomarkers and selections from Beethoven's Opus #135 after of disease but complements that with the research lunch at 12:30 p.m. All are welcome. Iii of social scientists, educators and cross-cultural communication experts. Under Greenwald's Calcium Study Seeks Subjects direction, the full gamut of clinical research, public An NIH study seeks healthy overweight adult health and communications techniques work volunteers for an examination of the health effects together, resulting in programs that aim for a of calcium supplementation over 2 years. Call 1- significant reduction in cancer incidence, morbidity 800-411-1222 (TTY: 1-866-411-1010). Compensa­ and mortality. tion is provided. Ill ACD MEETING, CONTINUED FROM PAGE 1 campus to consider the IH enterprise every June and critical to what happens to you. [For me], one and December. of them was meeting Bill Brody. If I have to count "I sort of feel like the father of the bride," Brody the three or four things that have been determining, quipped, before launching into an abbreviated I would say that crossing paths with Dr. Brody was biography of the new director that was sprinkled one of them." liberally with personal notes about the friendship The new NIH chief then contrasted his last

PHOTOS: BILL and high level of professional respect that have position with his current. Describing the various BRANSON developed over more than 20 years between himself hats he wore at JHU, Zerhouni joked about what he and Zerhouni. called "the Hopkins reengineering method-four "When President jobs for the price of one. The difference here Bush announced his though is I have one job and many bosses- Con­ intention to nomi­ gress, White House, the Administration. It's quite a nate Elias as director daunting position. With that as a preamble, I'm of NIH, a colleague very honored and excited to be here. I saw the of mine from the composition of the committee and I am very West Coast called me impressed and thankful for having your advice and and said, 'Gee, they support." appointed a radiolo­ Zerhouni said he'd had a lot of job offers over the gist. That's kind of years that he had "declined within 10 seconds," but unusual.' And I said, that he'd once acknowledged in a meeting that 'Well, describing Dr. "probably the only one I would consider is an NIH Zerhouni as a job, because I admire NIH." He had expressed In a brief radiologist is like describing Bill Gates as a computer similar feelings in a May 17 farewell message to ceremony programmer.' Elias is one of the most broad-gauged colleagues at Hopkins, writing, "You took me in beginning the people that I know in the field of medicine and and exposed me to an extraordinary environment 84th ACD biomedical science.'' for innovation and discovery. More than that, you provided me with great mentors who nurtured me meeting, NIH Warm Welcome and helped me become the physician, teacher, deputy director Himself an expert in the field of radiology, Brody researcher and executive I am today.. .! wouldn't Dr. Ruth continued, "Many of us in biomedical science strive have left Johns Hopkins for any other job." Kirsch stein to have an important discovery or invention, but Accountability, Communication Top Priority List passes the gavel Elias has had a number of them. I think in that to the group's regard, he's quite unusual. Early in his career, Elias Zerhouni then briefly touched on three new chair, NIH discovered that there was a way to differentiate overarching priorities he said he gleaned from his director Dr. benign from malignant nodules on computer meetings in Congress, his experiences during the Elias Zerhouni. technology, which then sparked a tremendous confirmation process and his 14 days on the job. Introducing the controversy because people couldn't reproduce the "The first and foremost message I received from new leader and work. So Elias then went into the detailed physics every senator, every congressman, everyone in the of computer tomography and showed why­ administration and outside the NIH community," he . joking that he depending on the type of scanner and how the said, "is the doubling of the budget and questions felt "like the method was conducted-you could come up with about whether or not it is well used. 'How do we father of the erroneous results. I think it was this work that know it is well used?' 'What does the public gain bride" is the made Elias a consultant to the Reagan White House for it?' There is a huge cry out there for account­ head of during President Ronald Reagan's illness." ability and transparency. This I think is going to be Zerhouni's Noting more of Zerhouni's breakthrough inven­ a constant theme over the next few years. This is a previous place tions, Brody said, "I could go on and on. He has a concern that really comes across every layer ofthe of employment, great sense of humor, he plays the lute and the many bosses that I'm talking about." ACD member piano, loves to scuba dive and listen to opera .. .It's a The second issue that Zerhouni said he "heard Dr. William great loss for Hopkins, but I think it's a wonderful over and over again" from everybody is "science Brody, president gain for NIH. Congratulations, Elias." policy being influenced more and more by ear­ Immediately revealing the quick sense of humor marks. This is something we need to grapple with" ofJohns alluded to in the introduction, Zerhouni began his and perhaps curb in some way. Hopkins remarks, smiling broadly: "First let me say thank "The last but not least concern," he concluded, "is University. you to Bill Brody for all his nice comments. Bill, if the level of expectation of the public such that there you had said all those things to me before, I would is now a cry for effective translation of the discover­ have stayed." ies into tangible benefits." Sobering, Zerhouni acknowledged, "There are few Elaborating, Zerhouni related a phenomenon that things that happen in one's life that are important was described to him to illustrate the point: "A hypothesis says, 'You know, the cure can be here in 5 memoranda of understanding and six new stem cell years, if we only had X amount of dollars.' One of lines meeting President Bush's criteria had been the fundamental difficulties we have is that the added to the registry. research enterprise is often compared to the moon For the remainder of the morning session, the shot strategy. 'Why is it that President Kennedy can agenda turned to the topic of science education and say we'll go to the moon in 10 years and we did it, career development. About a dozen students who and you scientists tell us you can't get a cure in 10 participate in the CityLab at Boston University, a years for one thing or another?'" program underwritten largely by the National Zerhouni said the issue proves why basic discourse Center for Research Resources, delivered a is needed with the public regarding "the realities of unique presentation about their experiences science." He said people involved in biomedical there. Lively and often punctuated with science need to spread the word.to the public: humor, the youngsters' enthusiasm was "When we talk about going to the moon, we're palpable, prompting Zerhouni to inquire really talking about an incremental technological whether ACD meetings were always so challenge. We know where the moon is. We see it much fun. every night. Fundamentally, we knew we could get "No," replied Dr. Thomas Cech, president there. We knew the laws of physics. We knew the of the Howard Hughes Medical Institute, laws of gravity. We knew escape velocities. That with a wry smile, drawing laughter from the kind of project was a technological challenge. other members. As members People need to convey the message that in biomedi­ Also offering details about NIH's forays in stimu­ introduced cal research we're not just dealing with a technologi­ lating even the youngest age groups to consider themselves cal challenge that has a well-defined endpoint and science for their futures were Dr. Bruce Fuchs, individually to scientists clear on just how we get there. We have a director of NIH's Office of Science Education, who knowledge challenge in many of these enterprises. discussed the NIH curriculum supplement series, Zerhouni, none That message is just not verbalized enough to make and Dr. LaShawn Drew, acting director of the NIH could resist the many bosses we have understand that this is the Academy, who talked about the possibility of offering salutes challenge for us. And, we're not communicating that expanding the academy. to Kirschstein. effectively. That is why we have this phenomenon of By the meeting's midpoint, the cordial tone of Observing their 'the cure will be here in 5 years if we spend X Zerhouni's ACD initiation had been well established, affection for his dollars.' In the minds of many people, it makes an primarily by the warm greetings that began the day. predecessor, the analogy between the moon shot and the War on "We've known each other for years, so I don't need chair quipped, Cancer and the Manhattan Project and medical to introduce myself to you," said ACD member Dr. "On my last research, when in fact there are fundamental gaps in Donald Wilson, vice president for medical affairs day, I wish knowledge that do not allow one to make those and dean of the School of Medicine at the University there would be predictions." of Maryland, addressing Zerhouni during the as much Getting Up to Speed greeting period and leading the first of many of the group's personal tributes to Kirschstein. "For at unanimous As is customary, the first business of the ACD least the last 30 years, I've been an employee of the sentiment. " meeting is to provide an update on major occur­ NIH for several days a year, and over this time it's rences at NIH in the last 6 months. Kirschstein been my privilege to work with our Ruth Kirschstein offered such a report, highlighting the congressional and I just want to thank her for all she's done over budget hearings and the status of search committees the years." for each of six vacant institute directorships. The Attempting to stave off the barrage of similar committee for the head of NIDA is poised to begin laudatory comments she sensed would follow, a interviewing candidates, NIMH's committee has noticeably embarrassed Kirschstein ordered that the interviewed already, NIAAA's is "moving apace" and verbal thanks cease. Still, as members introduced N INDS's is being reinstalled for a new search. At themselves individually to Zerhouni, none could NIBIB, Dr. Roderic Pettigrew, currently of Emory resist offering small salutes to Kirschstein. Observ­ University, has been appointed and will start in early ing their affection for his predecessor, the chair fall. Dr. Marvin Cassman's departure from NIGMS quipped, "On my last day, I wish there would be as since the last ACD meeting was acknowledged; a much unanimous sentiment." committee to fill the job there is under way. Breaking slightly with his fellow ACD colleagues, Kirschstein also noted that several vacancies on the but accurately reflecting another sentiment, Cech ACD roster had been deliberately left open in said, "At a time when one gets this type of position, anticipation of Zerhouni's arrival and subsequent Dr. Zerhouni, everyone says 'Congratulations.' I input on nominees. would instead like to say 'thank you,' which is a NIH deputy director for extramural research Dr. very different step, but I think that we appreciate the Wendy Baldwin then gave a short briefing on the leadership that we are about to receive." Iii stem cell registry and announced that three more FARMER, CONTINUED FROM PAGE 1 in Masur Auditorium May 24. could treat them were necessary from the outset. The paradoxes don't end with his demeanor and "Very few infectious pathogens do not acquire daunting professional milieus; he maintains that resistance to the drugs used to treat them." despite good intentions, the international public Farmer was quick to credit the value of basic health community's strategy to eradicate multidrug­ science, the "enormous yield" of scientific special­ resistant tuberculosis (MDR-TB)-a seeming ization, and the validity of scientific methods and triumph of compassionate intervention- was results. H e cautioned, however, that "science is a actually inept, harmful to patients, and only a socially constructed phenomenon" and that the managerial, as opposed to clinical, success. His choice of research questions and ways of interpret­ insight stems from field work among the world's ing associated data are "open to the same forces hardest medical cases, and it often involves having that influence other social affairs." to criticize large bureaucracies that lack his knack He took particular issue with a WHO statement in for person-to-person care. He speaks with the 1997 that "MDR-TB is too expensive to treat in authority of someone who makes poor countries; it detracts attention and resources · house calls on rag-roofed huts and from treating drug-susceptible disease." grimy, far-flung prisons. "That statement was particularly troubling to the Farmer's central interest, to be young men in Russian prisons and to the families in elaborated in a forthcoming book Peruvian slums," he said, "and happens to be called Pathologies of Power (the incorrect in both of its assertions." fourth in a series of front-line Farmer warned of " trans-national cases" of MDR­ public health analyses titled in TB, using the case history of a single patient- a 50- punchy, binary fashion) is discov­ year-old American relief worker in a Peruvian slum ering " how social inequalities get who returned to Boston where he was diagnosed in the body." Trained in both and later died. "Seventy percent of all cases of TB anthropology and medicine, he in Massachusens were diagnosed among foreign­ studies "what it means to live in a very inegalitarian ers," Farmer reported. "Such trans-national cases Dr. Suzanne world." He is indebted, he says, to a number of are very much not the exception-they are increas­ Heurtin-Roberts disciplines and counts as a major insight the exist­ ingly the rule." The migration of pathogens, he (l) of NCI, who ence of a "sociology of knowledge," which recog­ said, is common; "It has happened with every major cochairs the nizes that " all forms of knowledge are socially infectious epidemic in the world." He urged trans­ cultural and produced." Drawn to the study of worldwide national contact-tracing as a containment measure. qualitative epidemics (he was a panelist at a 2-day AIDS Reporting on his trips to a squatters' settlement in research interest retrospective given at NIH in fall 1993, decrying the northern Lima, Farmer said that active pulmonary group at NIH, treatment of HIV-positive Haitian detainees at the MDR-TB is common in local hospitals. More than introduced hands of the U.S. military), he says such outbreaks 450 untreated cases have been found there since 1996, he said. A WHO survey-drawing on Farmer on May "are not exclusively biological events. They are also different methodologies-of the same population 24. social ones." Employing a "biosocial" approach to the study of and era produced no cases. Deadpanned Farmer, disease, which takes into account " a number of "You can find them if you look properly." complementary analytic strategies," including Cases tend to be clustered in families, which makes molecular biology, political economy, medical sense given the transmission of MDR-TB by coughs anthropology, clinical outcomes and the sociology of and sneezes. So-called "imrahousehold transmis­ knowledge, he examined MDR-TB in two settings: sion" is rypical. The WHO-imported therapy of a prison in western Siberia, where he has served as DOTS- directly observed therapy, short course­ medical director, and an urban slum in Lima, where actuaJly harmed certain patients because its regimen "TB families" are ostracized and where some of antibiotics was already outwitted by the djsease, families feature as many as eight members with so that the rreatmenr was worse than placebo. active pulmonary MDR-TB. Cases thought to be "cured " were only temporarily In Russia, Farmer found that the rates of imprison­ suppressed by the antibiotics. ment vaulted from 285 per 100,000 to 700 per Farmer furcher found that capreomycin, a long­ 100,000 within just a few years; the elevated forgotten antibiotic that is cidal against TB, is priced detention rate was a major factor in the TB out­ far differently, depending upon where in the world break. you buy it. Ironically, TB has surpassed AIDS as the leading Turning lastly to Haiti, where he is medical infectious cause of death in the world, yet it is director of Clinique Bon Sauveur in the town of completely treatable, he said. Public health experts Cange, Farmer said that TB is rampant among HIV­ should have known that drug-resistant strains of positive patients; 5,000 of every 100,000 citizens are tuberculosis would develop and that strategies that coinfected. "You can't control T B in countries most affected by HIV," he said, "without taking on HIV HRDD Class Offerings as well." A wide array of conditions contribute to disease in The Human Resource Development Division Haiti, including poverty, execrable living conditions, supports the development of NIH human resources population and economic pressures, gender inequal­ through consultation and provides training, career ity, patterns of sexual union, and more. "HIV in development programs and other services designed part~ of Haiti is as bad as was predicted years ago, to enhance organizational performance. For more and m some areas worse," Farmer said. Still, he information call 496-6211 or visit http:// pointed hopefully to a reduction, starting in 1996, LearningSource.od.nih.gov. Regina H. White of AIDS mortality rates in the U.S., coinciding with has joined the NIH Retirement Seminar-FER$ 7/8, 9, 10 OD Office of the introduction of more effective therapies. New Introduction to MS Word 2000 719 Extramural drug combinations have reached even impoverished Preparing Manuscripts for Publication 719, 10 Research as areas, and Farmer read movingly from a Haitian English Pronunciation for the Non-Native director of the woman's message to the medical establishment: Speaker 7/11, 18, 8/1 Office of Policy "What can I say?" wrote a patient who appeared in Stressed For Success! Achieving for Extramural two slides-the first in which she looked ready to Work/Life Balance 7111 Research die, and the second in which she is beaming heart­ Creating and Maintaining Filing Systems 7/12 Administration. Intro to the NIH Knowledge Associate Cert ily-"The medicines are eloquent enough." She comes to Program 7/12, 15 NIH from the During a brief Q&A session with the audience, Managing Upward 7/12 Farmer noted some hopeful trends: the Brigham and University of Fundamentals of English 7/15-19 Vermont, where Women's Hospital has agreed to create a new Motivation at Work 7115 she spent 11 division in the department of medicine to examine Purchase Card Training 7115 years as director health inequalities-ironically, Farmer and his Basic Position Classification 7115-26 of the Office of colleagues will be allowed to see if the health­ Adventures in Attitudes 7/16 Sponsored worker model that was effective in Third World Critical Thinking 7/16 Programs. Haiti can be successfully imported to First World Delegated Acquisition Training Program 7116-19 Previously she Roxbury, Mass.; Farmer thinks NIH is increasingly Positive Approaches to Difficult People 7117 served as Valuing Differences interested in research proposals that incorporate 7/17 assistant director biosocial principles, and believes that "a new of the Office of research ethics agenda also requires a biosocial ADP Holds Annual Awards Ceremony Sponsored Research at approach, especially when research must be done Employees who have made outstanding contribu­ Harvard Univer­ across steep gradients of social inequality... A lot can tions to information technology use in the extramu­ sity, held the be done with better policies and more just distribu­ ral community were recognized recently by the NIH position of tion of the fruits of science," he concluded. Iii ADP extramural program coordination committee, president of the which held its annual award ceremony on May 22. National Council ~QT Computer Classes Chairperson Mary Ann Williamson made the of University presentations. Research All courses are on the N IH campus and are oiven Administrators Certificates of achievement were awarded to without charge. For more information call 594- and she founded 6248 or consult the training program's home page at Stephen Hughes, NCI, for serving as chair of the the Office of http://training.cit.nih.gov. IMPAC II technical coordinators meetings and as Grants Manage­ application programming interface advocate for I , Introduction to HTML 6/26 ment at the Creating Presentations w/PowerPoint for the PC 6/26 !MPAC II; and to members of the IMPAC II report­ Eunice Kennedy KMIG-Knowledge Management Interest Group 6/26 ing database redesign team, for continued efforts to Shriver Center for PowerPoint Topics: Graphs, Links and More 6/28 improve accessibility of data: Carol S. Martin of Mental Retarda­ NIH Enterprise Directory (NED) 6/29 NHGRI, and from OD/OER Johnnie Pearson, Leena tion. White spent mAdb Basic Informatics 7/2 Dtlawari, Vish Kaliappan, Lhadj Moumena, Amir 6 years in a Creating Presentations w/PowerPoint for the PC 7/2 Venegas and James Tucker. research lab Presentations: From PowerPoint to DVD 7/8 Certificates of appreciation were awarded to Cathy before pursuing a career in research Hands-on XML Schema 7/8-8/12 Buckley, CIT, for significant contribution to the NIH Relational Database Overview 7/9 administration. QueryNiew Reporting System development; Gre­ She has dedicated Data Warehouse Query: Research gory Fischetti, NCI, for providing outstanding Contracts & Grants her career to 7/9 leadership as 2001 chair of the NIH ADP-EP Understanding the Grants Process 7/10 bringing research Intermediate FileMaker Pro 5 7/10 coordination committee; Julie McDermott, OER, for faculty and Contractor Performance System 7110 exceptional service and support to the NIH extra­ administrators Titan Transition - Where's My Keyword? 7/10 mural business community; and Anne Robertson, together in Introduction to FrontPage 2000 7/11 NIDDK, for service over many years to the ADP collaborative, Budget Tracking 7/11 extramural program coordination committee. Iii fruitful relation­ Data Warehouse Analyze: Budget & Finance 7/11 ships. Former NIH Director Fredrickson Mourned

Senior r. Donald S. Fredrickson, 77, an authority on and Harvard Medical School prior to coming to Leadership Dlipid metabolism and its disorders who was NIH in 1953. Program IH director for 6 years (July 1, 1975, to June 30, In that year, he joined the scientific staff of the then 1981), died on June 7 at his home in Bethesda. National Heart Institute as a clinical associate. He Announced Only 6 days earlier, he had was among the first cadre of house staff for the then The Human accepted the NIH Alumni new Clinical Center. Resource Develop• Association's 2002 Public Fredrickson held numerous positions at NIH, ment Division is Service Award in a ceremony several in the heart institute simultaneously. From accepting at Bethesda United Method­ 1955 to 1961 he was a member of the Laboratory of nominations ist Church. And he had Cellular Physiology and Metabolism. He then through Aug. 2 for given a public lecture at NIH served as clinical director (1961-1966), while the fall session of last December on a topic for continuing his research as head of the section of the2002 NIH which he became famous: molecular diseases, Laboratory of Metabolism Senior Leadership legitimizing recombinant (1962-1966). He was appointed institute director in Program that DNA research at a time 1966, serving in that capacity until 1968. He begins Sept. 18. when public fears threatened combined this responsibility with research as chief of Targeted at IC to proscribe that avenue of Dr. Dona/a Fredrickson the Molecular Diseases Branch (1966-1974), and as leadership team s investigation. at June 1 NIHAA event director of intramural research (1969-1974). of senior scientific He said on Dec. 11, 2001, "We're.. .in the midst of His earliest research interests centered on the and administrative a revolution- and we have been for the past 30 metabolism of srerols. Later he focused on the leaders, the years-and it's the most important one in the history structure of the plasma lipoproteins, their impor­ program focuses of medicine and biology. I was in the first phase of tance in rhe transport of fats, and the genetic factors on the competen• it, and it was the most enjoyable period of my life, I regulating their metabolism and concentration in cies t hat w ere think." His remarks capsulized a book he had blood. It was during this period that he discovered identified as recently published, The Recombinallt DNA Contro· two new genetic disorders: Tangier disease (absence critically important 11ersy: A Memoir. The book's jacket reads, "In this of high density lipoproreins) and cholesteryl ester to meeting NIH's fascinating memoir, Donald Fredrickson tells the storage disease, a lysosomal enzyme deficiency. scientific goals. story of the controversy over recombinant DNA and In 1965, he and his coworkers introduced a system The program its revolutionary impact on modern science ...Rel ying for idemifying and classifying blood-lipid abnor­ combines case on vast archives of hearing records, correspondence, malities on the basis of plasma lipoprotein patterns. studies, interactive and extensive personal records and diaries, Dr. From this work came recognition of new causes of discussions, Fredrickson recalls the numerous personalities from hyperlipidemia. The system was adopted by labora­ experiential microbiology, molecular biology, and other scientific tories around the world . learning, assess• disciplines, as well as the leaders among Congress, Fredrickson and his colleagues also discovered mentdata, the administration, and government agencies, se,·eral previously unknown apolipoproteins, and development environmentalists, and many others, who had a role uncovered new knowledge including descriptions planning and a J. during this challenging period." concerning the structure and function of various day residential Said former IH deputy director Dr. Thomas apoproteins. retreat at The Inn Malone, "I was privileged to have served as Don's Before becoming NIH director, he served for 1 year at Perry Cabin, St. deputy from 1977 through 1981. This appointment (1974-1975) as president of the Institute of Medi­ Michaels, MD. The was one of the most fulfilling during my 20 years at cine, NAS. He was a member of numerous profes­ curriculum NIH. Following a superb and productive period of sional societies in addition to NAS and the American includes sessions bench research, he made the transition to the Academy of Arts and Sciences, was honored with 10 led by scholar• administrative sector with ease and grace. He honorary doctorates, and authored more than 270 practitioners and tackled head-on the questions generated by the new publications. He left the NIH directorship to return leaders and technologies. For example, he was at the center of to NAS as a visiting scholar. individual the recombinant DNA controversy and its solution. In 1983, he joined the Howard Hughes Medical feedback sessions. He was equally at home with science as he was with Institute as vice president, rising to president and For more informa• the great writers and philosophers, past and present. CEO in 1984; he left HHMI in 1987, and became a tion visit http:// He was a superb writer and speaker. I shall always scholar at the National Library of Medicine. His learningsource. remember his genius and wit and will be forever CV notes whimsically that, for 25 years, he was od.nih.gov/ appreciative that he passed my way." physician to King Hassan II of Morocco. main.pdf or Fredrickson was born Aug. 8, 1924, in Canon City, Burial took place in The Netherlands. He is contact Joyce Colo. He received both his B.S. (1946) and M.D. survived by his wife Henriette, and two sons, Eric ol Laplante at 496· (1949) from the University of Michigan, and was Columbus, Ohio, and Rurik, an NIAID employee, o 6211 or email certified by the American Board of Internal Medi­ Bethesda. A memorial service at NIH is planned for [email protected]. cine in 1957. He did postgraduate work at Peter the future. Iii Bent Brigham and Massachusetts General hospitals --~------

NIMH's Hazel Rea Dies at 91 By Sophia Glezos Voit azel Rea-the deeply loved "mother of the was more devoted to NIMH" than Hazel. "She will H (NIMH) intramural program," the self-taught, be greatly missed by everyone who knew her." undaunted secretary who rose to the second highest Adding to her assets was a keen working knowl­ position in NIMH intramural leadership-passed edge of the science, said NIMH away in her home on May 18, 3 months after her science writer Jules Asher, who 91st birthday and only 7 years after she retired. worked in the IRP during the According to many, including Dr. Julius Axelrod, 1980s. "Hazel was undaunted scientist emeritus and Nobel laureate, who also by her lack of formal training," recently turned 91, Rea was more than a deputy. he said. "She attended all the "She was the one who really ran the administra­ scientific reviews and got into tion," Axelrod said. "She made important decisions the nitty gritty of the re­ and was a very powerful person." search." And she "knew her power," he added, which may According to son-in-law have accounted for part of the reason she was able Hazel Rea Henry Hilken, "Hazel loved Identical to advance so far with comparatively little formal NIMH. She was intellectually Twins Needed scientific training. "A degree doesn't mean very challenged by the research they were doing and much," said Axelrod. "I published 25 papers before believed in it. Though I think she felt that during The HLA labora• I got my Ph.D. What was important to the people certain parts of her career she was held back tory in the who worked with Hazel Rea was that she was very because she was a woman, she never whined about department of knowledgeable, both about the institute and about it. She probably figured she had to overcome it by transfusion how to run things. She knew the intricacies of being smarter than everybody else and working medicine wants to NIMH." harder, and she was." compare T cell Born the second youngest of nine children, Rea left Middleton said Rea developed procedures for receptor reper­ her home state of Arkansas for adventure and a job attracting and recruiting women to NIMH that toires of healthy in the nation's capital. At the age of 24, back in predated the equal employment opportunity pro­ young adult 1935, she began her federal career at the Depart­ gram. identical twins ment of the Treasury. Fourteen years and several Though Rea often worked many hours past (ages 20-35). agencies later, she took a stenographer position at closing, she also carved out time to work on behalf Blood from NIMH, when the institute's staff totaled 60 employ­ of all NIH staff by taking the lead role in bringing healthy identical ees, in a 2-story building where, reportedly, only the the R&W to NIH, as one of its founding members. twin pairs is primates had the benefit of air conditioning. Randy Schools, president and CEO of the Recre­ needed. Each Over the years, Rea's administrative and analytical ation & Welfare Association, said Rea "took the tw in pair must abilities earned her increasing levels of responsibility, concept and brought it to the NIH community." answer a to the point of her ultimately becoming deputy Although other R&Ws existed, Rea was responsible questionnaire director of the Intramural Research Program. By in large part for NIH being among the early ones. about their age 80, she started working part-time, and finally "She helped plant the seed for all the programming medical history retired 4 years later, in 1995. that's now here in the NIH community," said and undergo HLA Pat Middleton, chief of the IRP Personnel Manage­ Schools. typing, complete ment Branch, who interviewed Rea in 1994 for an Granddaughter Whitney Perregino said her blood counts and article she was writing, said Hazel treated people grandmother's departure from NIMH was a difficult leukapheresis. with respect and knew how to appeal to their good break for her to make. "Retiring wasn't something Optimally, the side. that came easy to her," Perregino said. But she kept subjects should be "Hazel's direct advice to employees was that they in touch with colleagues and NIMH friends, "and available for 'should take their work seriously and believe in what they kept in touch with her. If she wasn't going to questioning about they are doing,' and that managers should 'deal the theater with them, she was visiting with them or their previous and honestly' with their staff. 'Always level with having parties." subsequent employees,' Hazel had said, 'and let them know She kept in touch with the science, too, particu­ medical history. when they are doing well or when they are not larly as it related to her own health. "She certainly Study participants performing,"' Middleton said. had a belief in the antioxidants," Perregino said, will be paid. Call In addition to a respectful regard of others, savvy, adding that in the last week of her life, her grand­ Cynthia Matthews and robust self-confidence, Rea also rose on the mother was saying she was "just too healthy. And I at 1·800-892-3276 wings of hard work, native intelligence, perseverance said, 'Well, with the stuff you cook all your life, or email and long hours. what d'ya want?' On the day she died, she took a cmatthews@ Dr. Robert Desimone, scientific director, who had very low dose of low blood pressure medication and mail.cc.nih.gov. worked with her for many years, told staff in an everything else was vitamins. She was very proud of email informing them about her death that "no one that. She was going to be 92 in February." Ill Seinfeld's 'George' Takes on Scleroderma he often unemployed, usually complaining and poorly understood. Talways self-centered George Costanza of Katz told the luncheon attendees he hoped their television's Seinfeld doesn't exactly conjure up efforts and the new research grants would result in pictures of volunteerism, dedication or brotherly better treatments for scleroderma and other autoim­ love. But it might be time to give George a little mune conditions. "And maybe now," he joked respect. The man behind the character-actor Jason when introducing Alexander, "Jason Alexander will Alexander-has all of these qualities, and he is using get some respect." his celebrity status to bring attention to the devastat­ "Don't bet on it," said Alexander.-Rachel Moore Iii ing impact of scleroderma, an autoimmune disease that affects his half-sister Karen Greenspan and killed her mother, Fay. Scleroderma (literally meaning "hard skin") is often referred to as a single disease, but actually it is a symptom of a group of diseases that involve the abnormal growth ' . ' '~ ~--·-,~t... j of connective ! tissue, which • .... r,I. - . . ·- . ,: - supports the skin ~ { t . I. and the internal ...~ . .. ·I. organs. In some Scleroderma forms of sclero­ spokespersons derma, hard, tight skin is the extent of the disease, Jason Alexander but in other forms, the disorder can severely affect TEAM NIH Races for the Cure-Team NIH members, (l) and Lauren blood vessels and internal organs such as the heart, 400 strong, braved the heat and humidity on June 1 to Beeson pose with lungs and kidneys. run and walk 3.1 miles in the National Race for the Cure NIAMS director As spokesman for the Scleroderma Foundation, in Washington, D. C. A throng of 70,000 race partici­ Dr. Stephen Katz. Alexander gave the keynote address at a luncheon pants took to the streets in support of research for breast the foundation held recently on Capitol Hill to cancer and related women's health initiatives. The increase legislators' awareness of the disease and to National Race is the world's largest SK event and is held honor the members and staff of the U.S. House and annually. Senate labor, health and human services, and education appropriations subcommittees. Dr. Stephen Katz, director of NIAMS, was a featured speaker at the luncheon, introducing Alexander and speaking about the 10 new research grants NIAMS funded this year-two with the Office of Research on Women's Health-which total more than $2 million per year. After Alexander cracked a few jokes about his new role as spokesman (it turns out he can be irreverent even when he's not wearing George's shoes), he talked about his half-sister's strength and courage throughout her ordeal with scleroderma. He encouraged the soft-spoken Greenspan to address the audience and tell her own story. Greenspan said her mother was diagnosed with scleroderma in 1952, and 4 years later, she died Wednesday Afternoon Lectures from it. Yet despite her mother's diagnosis, The Wednesday Afternoon Lecture series-held on Greenspan suffered from scleroderma for 13 years its namesake day at 3 p.m. in Masur Auditorium, before she was properly diagnosed. "My doctor Bldg. 10- features Sir Richard Peto on June 26; he is told me that there was nothing wrong with me that professor of medical statistics and epidemiology, a new boyfriend and a yoga class wouldn't cure," Oxford University. He will give the annual Robert she said. She went undiagnosed for so long, she S. Gordon Jr. Lecture on "Halving Premature thinks, partly because she did not have the skin Death." manifestations considered to be the hallmark of the For more information or for reasonable accommo­ disease and partly because scleroderma was so dation, call Hilda Madine, 594-5595. Iii